SLC35B2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: Sulfotransferases (e.g., SULT4A1; MIM 608359) use an activated form of sulfate, 3-prime-phosphoadenosine 5-prime-phosphosulfate (PAPS), as a common sulfate donor for sulfation of glycoproteins, proteoglycans, and glycolipids in the endoplasmic reticulum and Golgi apparatus. SLC35B2 is located in the microsomal membrane and transports PAPS from the cytosol, where it is synthesized, into the Golgi lumen (Kamiyama et al., 2003 [PubMed 12716889]). NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1protein maturation by protein folding (GO:0022417)4.79826692
2COPI coating of Golgi vesicle (GO:0048205)4.53652543
3Golgi transport vesicle coating (GO:0048200)4.53652543
4UV protection (GO:0009650)4.19150944
5retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)4.16640282
6basement membrane organization (GO:0071711)4.06518404
7protein retention in ER lumen (GO:0006621)3.96082074
8maintenance of protein localization in endoplasmic reticulum (GO:0035437)3.95673893
9signal peptide processing (GO:0006465)3.90492729
10deoxyribonucleoside monophosphate metabolic process (GO:0009162)3.86744000
11skin morphogenesis (GO:0043589)3.84321064
12DNA deamination (GO:0045006)3.81276935
13negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)3.77815060
14nucleotide-sugar biosynthetic process (GO:0009226)3.74675189
15hemidesmosome assembly (GO:0031581)3.70299866
16type B pancreatic cell proliferation (GO:0044342)3.69039486
17DNA strand elongation involved in DNA replication (GO:0006271)3.57548955
18protein carboxylation (GO:0018214)3.55152715
19peptidyl-glutamic acid carboxylation (GO:0017187)3.55152715
20protein hydroxylation (GO:0018126)3.53675058
21telomere maintenance via semi-conservative replication (GO:0032201)3.48159456
22regulation of mammary gland epithelial cell proliferation (GO:0033599)3.46047178
23peptidyl-proline hydroxylation (GO:0019511)3.45307790
24GDP-mannose metabolic process (GO:0019673)3.44509100
25G-protein coupled receptor signaling pathway coupled to cGMP nucleotide second messenger (GO:00071993.37237200
26ribosomal small subunit assembly (GO:0000028)3.35667135
27pentose-phosphate shunt (GO:0006098)3.35377502
28DNA strand elongation (GO:0022616)3.35206948
29planar cell polarity pathway involved in neural tube closure (GO:0090179)3.27733772
30SRP-dependent cotranslational protein targeting to membrane (GO:0006614)3.27668868
31antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)3.27422894
32antigen processing and presentation of endogenous peptide antigen (GO:0002483)3.27422894
33melanin biosynthetic process (GO:0042438)3.27361374
34regulation of low-density lipoprotein particle receptor biosynthetic process (GO:0045714)3.26497653
35NADPH regeneration (GO:0006740)3.24497082
36cell adhesion mediated by integrin (GO:0033627)3.21573829
37cotranslational protein targeting to membrane (GO:0006613)3.19891259
38protein targeting to ER (GO:0045047)3.19838224
39protein localization to endoplasmic reticulum (GO:0070972)3.06882934
40protein autoprocessing (GO:0016540)3.03611117
41protein localization to endosome (GO:0036010)3.03562404
42regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)3.03066199
43regulation of metalloenzyme activity (GO:0048552)3.02858639
44establishment of protein localization to endoplasmic reticulum (GO:0072599)3.02082284
45negative regulation of cell size (GO:0045792)3.00826147
46L-serine metabolic process (GO:0006563)2.99595108
47proline biosynthetic process (GO:0006561)2.98695095
48folic acid-containing compound biosynthetic process (GO:0009396)2.94106957
49cell-substrate junction assembly (GO:0007044)2.93240905
50barbed-end actin filament capping (GO:0051016)2.91943704
51COPII vesicle coating (GO:0048208)2.89835272
52regulation of translational fidelity (GO:0006450)2.87335062
53pinocytosis (GO:0006907)2.84365437
54melanin metabolic process (GO:0006582)2.83410810
55regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)2.82350295
56L-methionine biosynthetic process from methylthioadenosine (GO:0019509)2.82114537
57endoplasmic reticulum unfolded protein response (GO:0030968)2.80650950
58serine family amino acid biosynthetic process (GO:0009070)2.79705561
59telomere maintenance via recombination (GO:0000722)2.79087925
60pteridine-containing compound biosynthetic process (GO:0042559)2.77941687
61desmosome organization (GO:0002934)2.77518600
62regulation of vascular endothelial growth factor signaling pathway (GO:1900746)2.76315588
63positive regulation of extrinsic apoptotic signaling pathway in absence of ligand (GO:2001241)2.73975394
64hyaluronan catabolic process (GO:0030214)2.73783372
65nucleoside salvage (GO:0043174)2.73361581
66viral transcription (GO:0019083)2.72351034
67semaphorin-plexin signaling pathway (GO:0071526)2.71387215
68DNA strand renaturation (GO:0000733)2.70819204
69endoplasmic reticulum calcium ion homeostasis (GO:0032469)2.66324148
70regulation of nuclease activity (GO:0032069)2.66245557
71negative regulation of glycoprotein biosynthetic process (GO:0010561)2.65098039
72glucose 6-phosphate metabolic process (GO:0051156)2.64746347
73cell-substrate adherens junction assembly (GO:0007045)2.64697591
74focal adhesion assembly (GO:0048041)2.64697591
75antigen processing and presentation of endogenous antigen (GO:0019883)2.63254179
76protein insertion into membrane (GO:0051205)2.63165044
77translational termination (GO:0006415)2.61951732
78DNA replication initiation (GO:0006270)2.61126101
79peptidyl-arginine omega-N-methylation (GO:0035247)2.61109164
80vesicle coating (GO:0006901)2.60865503
81dichotomous subdivision of an epithelial terminal unit (GO:0060600)2.60328179
82ER-nucleus signaling pathway (GO:0006984)2.59914099
83cellular response to unfolded protein (GO:0034620)2.59493390
84muscle cell migration (GO:0014812)2.58337512
85stress fiber assembly (GO:0043149)2.57500794
86L-phenylalanine metabolic process (GO:0006558)2.56983588
87erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)2.56983588
88alpha-linolenic acid metabolic process (GO:0036109)2.56628053
89adherens junction assembly (GO:0034333)2.55596677
90negative regulation of release of cytochrome c from mitochondria (GO:0090201)2.54621559
91heme biosynthetic process (GO:0006783)2.52253077
92peptidyl-histidine modification (GO:0018202)2.51574194
93embryo implantation (GO:0007566)2.50572690
94actin filament depolymerization (GO:0030042)2.50255708
95epithelial cell-cell adhesion (GO:0090136)2.50212710
96nuclear envelope reassembly (GO:0031468)2.48957772
97mitotic nuclear envelope reassembly (GO:0007084)2.48957772
98formation of translation preinitiation complex (GO:0001731)2.48824397
99protein N-linked glycosylation via asparagine (GO:0018279)2.48251485
100pyrimidine nucleoside salvage (GO:0043097)2.48009116
101pyrimidine-containing compound salvage (GO:0008655)2.48009116
102negative regulation of chondrocyte differentiation (GO:0032331)2.47700598
103regulation of early endosome to late endosome transport (GO:2000641)2.47590895
104regulation of cholesterol biosynthetic process (GO:0045540)2.47559127
105regulation of cholesterol metabolic process (GO:0090181)2.46448356
106cellular response to topologically incorrect protein (GO:0035967)2.45973782
107branching involved in mammary gland duct morphogenesis (GO:0060444)2.45512974
108endothelial cell chemotaxis (GO:0035767)2.45453604
109cellular copper ion homeostasis (GO:0006878)2.45008271
110gonadal mesoderm development (GO:0007506)2.44623534
111negative regulation of cell aging (GO:0090344)2.44540230
112antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO:2.43978695
113membrane protein ectodomain proteolysis (GO:0006509)2.43932765
114amyloid precursor protein catabolic process (GO:0042987)2.43861331
115regulation of Arp2/3 complex-mediated actin nucleation (GO:0034315)2.43813412
116peptidyl-asparagine modification (GO:0018196)2.43788967
117translational elongation (GO:0006414)2.43450323
118DNA unwinding involved in DNA replication (GO:0006268)2.43064630
119cellular zinc ion homeostasis (GO:0006882)2.42518960
120L-methionine salvage (GO:0071267)2.42416530
121L-methionine biosynthetic process (GO:0071265)2.42416530
122amino acid salvage (GO:0043102)2.42416530
123modulation by virus of host morphology or physiology (GO:0019048)2.42387248
124secondary metabolite biosynthetic process (GO:0044550)2.41865857
125glyoxylate metabolic process (GO:0046487)2.41658891
126erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)2.39488854
127L-phenylalanine catabolic process (GO:0006559)2.39488854
128mitotic recombination (GO:0006312)2.39111019
129nucleotide-excision repair, DNA gap filling (GO:0006297)2.38235981
130proline metabolic process (GO:0006560)2.38211012
131glucose catabolic process (GO:0006007)2.37999421
132keratan sulfate catabolic process (GO:0042340)2.37038018
133lipopolysaccharide biosynthetic process (GO:0009103)2.36815181
134proteasome assembly (GO:0043248)2.36085012
135establishment of viral latency (GO:0019043)2.35730369
136protein N-linked glycosylation (GO:0006487)2.34928706
137translation (GO:0006412)2.34844626
1384-hydroxyproline metabolic process (GO:0019471)2.34706651
139dolichol-linked oligosaccharide biosynthetic process (GO:0006488)2.34210926
140folic acid metabolic process (GO:0046655)2.34091136
141maintenance of protein localization in organelle (GO:0072595)2.33545511
142pyrimidine nucleoside monophosphate biosynthetic process (GO:0009130)2.32940903
143rRNA modification (GO:0000154)2.32608001
144regulation of extracellular matrix disassembly (GO:0010715)2.32049880
145antigen processing and presentation of exogenous peptide antigen via MHC class I (GO:0042590)2.31513683
146activation of Rac GTPase activity (GO:0032863)2.31449802
147positive regulation of nuclease activity (GO:0032075)2.30727281
148positive regulation of receptor biosynthetic process (GO:0010870)2.29558198
149mitotic chromosome condensation (GO:0007076)2.29445621
150translesion synthesis (GO:0019985)2.28975439
151rRNA methylation (GO:0031167)2.27877440
152glutamine family amino acid biosynthetic process (GO:0009084)2.27691066
153pyrimidine nucleoside monophosphate metabolic process (GO:0009129)2.27637677
154heme metabolic process (GO:0042168)2.27529853
155glycolytic process (GO:0006096)2.27059552
156facial nerve structural organization (GO:0021612)2.26086194
157monosaccharide biosynthetic process (GO:0046364)2.25793133
158telomere maintenance via telomere lengthening (GO:0010833)2.25340538
159negative regulation of glycoprotein metabolic process (GO:1903019)2.25252725
160establishment of integrated proviral latency (GO:0075713)2.24980801
161cellular metabolic compound salvage (GO:0043094)2.23057937
162viral life cycle (GO:0019058)2.22101531
163cholesterol biosynthetic process (GO:0006695)2.21913775
164purine-containing compound salvage (GO:0043101)2.21550232
165sulfur amino acid catabolic process (GO:0000098)2.21500819
166activation of signaling protein activity involved in unfolded protein response (GO:0006987)2.20860813
167adhesion of symbiont to host (GO:0044406)2.20209586
168fatty acid elongation (GO:0030497)2.19776557
169GMP metabolic process (GO:0046037)2.19691648
170nucleotide salvage (GO:0043173)2.19256817
171valine metabolic process (GO:0006573)2.17692777
172pentose metabolic process (GO:0019321)2.16507263
173creatine metabolic process (GO:0006600)2.16136754
174Arp2/3 complex-mediated actin nucleation (GO:0034314)2.14549651
175NADP metabolic process (GO:0006739)2.12795529

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human3.93869019
2EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.57022713
3TP63_17297297_ChIP-ChIP_HaCaT_Human3.45028785
4SOX9_22984422_ChIP-ChIP_TESTIS_Rat3.13867863
5NOTCH1_17114293_ChIP-ChIP_T-ALL_Human3.07270938
6MYC_18555785_ChIP-Seq_MESCs_Mouse2.85264132
7KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.71024637
8ESR1_17901129_ChIP-ChIP_LIVER_Mouse2.67010730
9GABP_17652178_ChIP-ChIP_JURKAT_Human2.52859459
10ZNF263_19887448_ChIP-Seq_K562_Human2.51885730
11JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.50936463
12MYC_18358816_ChIP-ChIP_MESCs_Mouse2.35065092
13CREB1_15753290_ChIP-ChIP_HEK293T_Human2.23594561
14ETS1_20019798_ChIP-Seq_JURKAT_Human2.22345830
15RACK7_27058665_Chip-Seq_MCF-7_Human2.17626687
16EST1_17652178_ChIP-ChIP_JURKAT_Human2.11495982
17PPARG_19300518_ChIP-PET_3T3-L1_Mouse2.08207115
18CEBPA_23403033_ChIP-Seq_LIVER_Mouse2.06518665
19MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.00481162
20* TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.97950872
21HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.96725810
22CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.95332626
23MYC_19030024_ChIP-ChIP_MESCs_Mouse1.87790058
24* SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.87242416
25XRN2_22483619_ChIP-Seq_HELA_Human1.86704972
26* E2F1_18555785_ChIP-Seq_MESCs_Mouse1.84567094
27VDR_21846776_ChIP-Seq_THP-1_Human1.84510922
28HIF1A_21447827_ChIP-Seq_MCF-7_Human1.84458883
29TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.82538318
30ELF1_17652178_ChIP-ChIP_JURKAT_Human1.78334809
31NELFA_20434984_ChIP-Seq_ESCs_Mouse1.77447958
32RXR_22158963_ChIP-Seq_LIVER_Mouse1.76603861
33PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.72638255
34ERG_20887958_ChIP-Seq_HPC-7_Mouse1.69629168
35DCP1A_22483619_ChIP-Seq_HELA_Human1.69245403
36PPARA_22158963_ChIP-Seq_LIVER_Mouse1.68447286
37FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.67842720
38NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.66687147
39* FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.65233822
40TET1_21451524_ChIP-Seq_MESCs_Mouse1.64068271
41CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.62849092
42MYC_19079543_ChIP-ChIP_MESCs_Mouse1.62245318
43GABP_19822575_ChIP-Seq_HepG2_Human1.61557735
44ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.61122721
45* VDR_23849224_ChIP-Seq_CD4+_Human1.59634360
46TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.58737083
47SRY_22984422_ChIP-ChIP_TESTIS_Rat1.57174645
48CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.56836622
49SCL_19346495_ChIP-Seq_HPC-7_Human1.56559014
50* SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.53266332
51MYC_22102868_ChIP-Seq_BL_Human1.51564926
52* SRF_21415370_ChIP-Seq_HL-1_Mouse1.51530775
53* ZFX_18555785_ChIP-Seq_MESCs_Mouse1.51115721
54P68_20966046_ChIP-Seq_HELA_Human1.50615150
55ATF3_27146783_Chip-Seq_COLON_Human1.47924633
56NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.47811217
57KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.47576465
58RARG_19884340_ChIP-ChIP_MEFs_Mouse1.46703511
59THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.46537715
60KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.46358269
61CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.45993385
62* RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.44146256
63UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.44015872
64ESR2_21235772_ChIP-Seq_MCF-7_Human1.43218923
65KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.42569783
66SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.42115037
67TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.40519326
68CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.40262971
69FOXP3_21729870_ChIP-Seq_TREG_Human1.39231271
70* THAP11_20581084_ChIP-Seq_MESCs_Mouse1.33629827
71TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.32164096
72TP53_22127205_ChIP-Seq_IMR90_Human1.31202173
73CTCF_27219007_Chip-Seq_ERYTHROID_Human1.30267374
74AR_21909140_ChIP-Seq_LNCAP_Human1.30247477
75KDM2B_26808549_Chip-Seq_SUP-B15_Human1.28782596
76RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.28651519
77* VDR_24763502_ChIP-Seq_THP-1_Human1.28635401
78HOXB4_20404135_ChIP-ChIP_EML_Mouse1.27093451
79MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.26778185
80STAT6_21828071_ChIP-Seq_BEAS2B_Human1.26378446
81ELK3_25401928_ChIP-Seq_HUVEC_Human1.26144689
82ERG_21242973_ChIP-ChIP_JURKAT_Human1.25772669
83SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.25629231
84* FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.25298273
85CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.24771431
86HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.24653444
87FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.24387236
88* SPI1_23547873_ChIP-Seq_NB4_Human1.24123050
89TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.22188866
90CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.21850623
91P300_27058665_Chip-Seq_ZR-75-30cells_Human1.20716173
92KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.20521235
93POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.20218308
94SA1_27219007_Chip-Seq_ERYTHROID_Human1.19177525
95CNOT3_19339689_ChIP-ChIP_MESCs_Mouse1.18493786
96CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.18160178
97RARB_24833708_ChIP-Seq_LIVER_Mouse1.17628736
98UBF1/2_26484160_Chip-Seq_HMECs_Human1.17540660
99SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.17274183
100SREBP2_21459322_ChIP-Seq_LIVER_Mouse1.17082359
101FOXM1_23109430_ChIP-Seq_U2OS_Human1.16969698
102* TFEB_21752829_ChIP-Seq_HELA_Human1.16871799
103CLOCK_20551151_ChIP-Seq_293T_Human1.16041070
104ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.15995947
105GATA1_22383799_ChIP-Seq_G1ME_Mouse1.15543462
106* MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.14985595
107CIITA_25753668_ChIP-Seq_RAJI_Human1.14886528
108RARA_24833708_ChIP-Seq_LIVER_Mouse1.14001341
109DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.13351578
110ESR1_15608294_ChIP-ChIP_MCF-7_Human1.13107064
111PPARD_23208498_ChIP-Seq_MDA-MB-231_Human1.12508338
112MYCN_18555785_ChIP-Seq_MESCs_Mouse1.12507039
113* FOXP1_21924763_ChIP-Seq_HESCs_Human1.12283397
114HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.12144749
115SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.11574573
116ZFP281_18757296_ChIP-ChIP_E14_Mouse1.11496259
117* GFI1B_20887958_ChIP-Seq_HPC-7_Mouse1.11323416
118ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.10981292
119EGR1_23403033_ChIP-Seq_LIVER_Mouse1.10871996
120ATF3_23680149_ChIP-Seq_GBM1-GSC_Human1.10692206
121SMC4_20622854_ChIP-Seq_HELA_Human1.10271864
122E2F4_17652178_ChIP-ChIP_JURKAT_Human1.09578810
123ELF1_20517297_ChIP-Seq_JURKAT_Human1.09054883
124TTF2_22483619_ChIP-Seq_HELA_Human1.07052649
125YY1_21170310_ChIP-Seq_MESCs_Mouse1.06684073
126* TBX5_21415370_ChIP-Seq_HL-1_Mouse1.06581507
127* SETDB1_19884255_ChIP-Seq_MESCs_Mouse1.05987442
128* HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.05707647
129PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.05435721
130POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.05215706
131TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.05018350
132NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.04683034
133SREBP1_19666523_ChIP-Seq_LIVER_Mouse1.04239649
134* BCOR_27268052_Chip-Seq_Bcells_Human1.04196727
135* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.03820425
136TRIM28_21343339_ChIP-Seq_HEK293_Human1.03634085
137KDM2B_26808549_Chip-Seq_DND41_Human1.03597488
138KDM5A_27292631_Chip-Seq_BREAST_Human1.02908566
139DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.02799285
140* MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.02675363
141PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.01826254
142EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.01821109
143IRF8_22096565_ChIP-ChIP_GC-B_Human1.01594430
144NCOR1_26117541_ChIP-Seq_K562_Human1.01406833
145IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.01255209
146STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse0.99985330
147* LXR_22292898_ChIP-Seq_THP-1_Human0.99540448
148TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.99344356
149E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human0.98845865
150PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse0.98506208
151NANOG_18555785_ChIP-Seq_MESCs_Mouse0.96955285
152BRD4_27068464_Chip-Seq_AML-cells_Mouse0.96649781
153STAT3_1855785_ChIP-Seq_MESCs_Mouse0.95752575
154KLF4_18555785_ChIP-Seq_MESCs_Mouse0.94833936
155E2F1_21310950_ChIP-Seq_MCF-7_Human0.94335074
156LXR_22158963_ChIP-Seq_LIVER_Mouse0.93792428
157BCL3_23251550_ChIP-Seq_MUSCLE_Mouse0.93353537
158MYB_21317192_ChIP-Seq_ERMYB_Mouse0.92356288

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005171_absent_coat_pigmentation4.56199108
2MP0005257_abnormal_intraocular_pressure3.74410162
3MP0008438_abnormal_cutaneous_collagen3.10412138
4MP0003806_abnormal_nucleotide_metabolis3.07022550
5MP0009840_abnormal_foam_cell3.00040951
6MP0004272_abnormal_basement_membrane2.82826213
7MP0003566_abnormal_cell_adhesion2.69744895
8MP0003136_yellow_coat_color2.69593597
9MP0005451_abnormal_body_composition2.57206583
10MP0002139_abnormal_hepatobiliary_system2.43082760
11MP0005083_abnormal_biliary_tract2.35653399
12MP0006054_spinal_hemorrhage2.35134506
13MP0000751_myopathy2.31872063
14MP0005365_abnormal_bile_salt2.18738159
15MP0005409_darkened_coat_color2.17917551
16MP0005220_abnormal_exocrine_pancreas2.16468043
17MP0002396_abnormal_hematopoietic_system2.08590871
18MP0001849_ear_inflammation2.06246005
19MP0004858_abnormal_nervous_system1.94715250
20MP0005360_urolithiasis1.94169247
21MP0005623_abnormal_meninges_morphology1.89319724
22MP0000685_abnormal_immune_system1.86032021
23MP0008260_abnormal_autophagy1.84159500
24MP0004233_abnormal_muscle_weight1.79133577
25MP0001666_abnormal_nutrient_absorption1.73413342
26MP0005174_abnormal_tail_pigmentation1.65405916
27MP0005058_abnormal_lysosome_morphology1.65285606
28MP0003186_abnormal_redox_activity1.62034626
29MP0003453_abnormal_keratinocyte_physiol1.59539453
30MP0000003_abnormal_adipose_tissue1.58896049
31MP0001243_abnormal_dermal_layer1.58094315
32MP0005501_abnormal_skin_physiology1.54747821
33MP0009384_cardiac_valve_regurgitation1.54028523
34MP0003091_abnormal_cell_migration1.53335573
35MP0003111_abnormal_nucleus_morphology1.53118585
36MP0005076_abnormal_cell_differentiation1.52430372
37MP0010234_abnormal_vibrissa_follicle1.51350693
38MP0003656_abnormal_erythrocyte_physiolo1.50998044
39MP0003172_abnormal_lysosome_physiology1.49084441
40MP0003191_abnormal_cellular_cholesterol1.46199465
41MP0000490_abnormal_crypts_of1.45128943
42MP0000013_abnormal_adipose_tissue1.44657057
43MP0003195_calcinosis1.41961233
44MP0000465_gastrointestinal_hemorrhage1.41871406
45MP0005085_abnormal_gallbladder_physiolo1.39000935
46MP0000462_abnormal_digestive_system1.36381917
47MP0005023_abnormal_wound_healing1.35384849
48MP0005503_abnormal_tendon_morphology1.31798396
49MP0000015_abnormal_ear_pigmentation1.31656929
50MP0002933_joint_inflammation1.27908049
51MP0003283_abnormal_digestive_organ1.27642962
52MP0003693_abnormal_embryo_hatching1.26968907
53MP0009643_abnormal_urine_homeostasis1.26758895
54MP0010030_abnormal_orbit_morphology1.24117820
55MP0005408_hypopigmentation1.24038939
56MP0000750_abnormal_muscle_regeneration1.23363363
57MP0004381_abnormal_hair_follicle1.22822408
58MP0005332_abnormal_amino_acid1.19812531
59MP0008007_abnormal_cellular_replicative1.17245524
60MP0009333_abnormal_splenocyte_physiolog1.17128635
61MP0005075_abnormal_melanosome_morpholog1.16633188
62MP0005464_abnormal_platelet_physiology1.14665812
63MP0001533_abnormal_skeleton_physiology1.14307289
64MP0009278_abnormal_bone_marrow1.14285787
65MP0003941_abnormal_skin_development1.13889295
66MP0003436_decreased_susceptibility_to1.13341924
67MP0000538_abnormal_urinary_bladder1.13332334
68MP0000534_abnormal_ureter_morphology1.11161695
69MP0005197_abnormal_uvea_morphology1.10413603
70MP0004957_abnormal_blastocyst_morpholog1.09700103
71MP0000566_synostosis1.09022227
72MP0009053_abnormal_anal_canal1.08541570
73MP0002796_impaired_skin_barrier1.07319159
74MP0000762_abnormal_tongue_morphology1.06691734
75MP0000609_abnormal_liver_physiology1.06178137
76MP0000537_abnormal_urethra_morphology1.05542625
77MP0000767_abnormal_smooth_muscle1.04235204
78MP0010368_abnormal_lymphatic_system1.04022920
79MP0004134_abnormal_chest_morphology1.03195653
80MP0001835_abnormal_antigen_presentation1.02111735
81MP0002896_abnormal_bone_mineralization1.01405964
82MP0000733_abnormal_muscle_development1.01246665
83MP0003724_increased_susceptibility_to1.00797133
84MP0002419_abnormal_innate_immunity1.00410853
85MP0008469_abnormal_protein_level0.99745024
86MP0008058_abnormal_DNA_repair0.97680083
87MP0005423_abnormal_somatic_nervous0.97590745
88MP0001542_abnormal_bone_strength0.97453943
89MP0004147_increased_porphyrin_level0.97266045
90MP0008932_abnormal_embryonic_tissue0.96918152
91MP0003942_abnormal_urinary_system0.96753532
92MP0005621_abnormal_cell_physiology0.96633468
93MP0000598_abnormal_liver_morphology0.96359969
94MP0003385_abnormal_body_wall0.96152149
95MP0001216_abnormal_epidermal_layer0.95898503
96MP0004133_heterotaxia0.94089389
97MP0003705_abnormal_hypodermis_morpholog0.94036801
98MP0000858_altered_metastatic_potential0.93596068
99MP0000358_abnormal_cell_content/0.93271069
100MP0002118_abnormal_lipid_homeostasis0.92472474
101MP0010771_integument_phenotype0.92183600
102MP0003077_abnormal_cell_cycle0.91840096
103MP0005275_abnormal_skin_tensile0.91407203
104MP0001545_abnormal_hematopoietic_system0.91181324
105MP0005397_hematopoietic_system_phenotyp0.91181324
106MP0005330_cardiomyopathy0.91054327
107MP0008875_abnormal_xenobiotic_pharmacok0.90852103
108MP0005381_digestive/alimentary_phenotyp0.89409364
109MP0003279_aneurysm0.89394386
110MP0005390_skeleton_phenotype0.89311444
111MP0005319_abnormal_enzyme/_coenzyme0.89057074
112MP0001873_stomach_inflammation0.89045043
113MP0002877_abnormal_melanocyte_morpholog0.88368920
114MP0002075_abnormal_coat/hair_pigmentati0.88100885
115MP0010155_abnormal_intestine_physiology0.87438364
116MP0002938_white_spotting0.87228291
117MP0010329_abnormal_lipoprotein_level0.86984227
118MP0003795_abnormal_bone_structure0.86699558
119MP0001661_extended_life_span0.86691798
120MP0000343_altered_response_to0.85920661
121MP0000747_muscle_weakness0.85703464
122MP0003300_gastrointestinal_ulcer0.85038675
123MP0005025_abnormal_response_to0.84336602
124MP0000163_abnormal_cartilage_morphology0.82714964
125MP0003115_abnormal_respiratory_system0.82296982
126MP0002080_prenatal_lethality0.82213936
127MP0001186_pigmentation_phenotype0.82173843
128MP0000678_abnormal_parathyroid_gland0.82003633
129MP0009763_increased_sensitivity_to0.81565814
130MP0000467_abnormal_esophagus_morphology0.80395883
131MP0000920_abnormal_myelination0.80019384
132MP0000689_abnormal_spleen_morphology0.79553599
133MP0005584_abnormal_enzyme/coenzyme_acti0.79041655
134MP0003315_abnormal_perineum_morphology0.79027902
135MP0004808_abnormal_hematopoietic_stem0.78889324
136MP0000350_abnormal_cell_proliferation0.78577820
137MP0005508_abnormal_skeleton_morphology0.78492706
138MP0009931_abnormal_skin_appearance0.77902128
139MP0005384_cellular_phenotype0.77855771
140MP0004264_abnormal_extraembryonic_tissu0.77482084
141MP0001958_emphysema0.77295555
142MP0001944_abnormal_pancreas_morphology0.76373773
143MP0005000_abnormal_immune_tolerance0.76112558
144MP0009785_altered_susceptibility_to0.75248206
145MP0001299_abnormal_eye_distance/0.75080428
146MP0002089_abnormal_postnatal_growth/wei0.74743925
147MP0001915_intracranial_hemorrhage0.74645721
148MP0001845_abnormal_inflammatory_respons0.74491345
149MP0003329_amyloid_beta_deposits0.74118867
150MP0002060_abnormal_skin_morphology0.74072114
151MP0002429_abnormal_blood_cell0.74046182
152MP0001730_embryonic_growth_arrest0.73808760
153MP0001756_abnormal_urination0.72065911
154MP0001663_abnormal_digestive_system0.71947924
155MP0006036_abnormal_mitochondrial_physio0.71906773
156MP0000477_abnormal_intestine_morphology0.71527090
157MP0000371_diluted_coat_color0.71268277
158MP0000613_abnormal_salivary_gland0.70959926
159MP0002177_abnormal_outer_ear0.70734622
160MP0005671_abnormal_response_to0.69718647
161MP0003123_paternal_imprinting0.69687272
162MP0002722_abnormal_immune_system0.69307194
163MP0002452_abnormal_antigen_presenting0.69281606
164MP0009765_abnormal_xenobiotic_induced0.69214723
165MP0000759_abnormal_skeletal_muscle0.68616994
166MP0000749_muscle_degeneration0.68177792
167MP0001340_abnormal_eyelid_morphology0.64574928
168MP0005165_increased_susceptibility_to0.63402197

Predicted human phenotypes

RankGene SetZ-score
1Ulnar bowing (HP:0003031)4.06057089
2Testicular atrophy (HP:0000029)3.57686276
3Thin bony cortex (HP:0002753)3.25897827
4Poikiloderma (HP:0001029)3.22625409
5Abnormality of aromatic amino acid family metabolism (HP:0004338)3.18064155
6Flattened epiphyses (HP:0003071)3.10285184
7Protrusio acetabuli (HP:0003179)3.04180202
8Flat capital femoral epiphysis (HP:0003370)2.98941126
9Irregular vertebral endplates (HP:0003301)2.96484913
10Reduced antithrombin III activity (HP:0001976)2.83792861
11Abnormal protein glycosylation (HP:0012346)2.80202139
12Abnormal glycosylation (HP:0012345)2.80202139
13Abnormal isoelectric focusing of serum transferrin (HP:0003160)2.80202139
14Abnormal protein N-linked glycosylation (HP:0012347)2.80202139
15Hypoglycemic coma (HP:0001325)2.76832372
16Abnormality of long-chain fatty-acid metabolism (HP:0010964)2.74669585
17Hyperacusis (HP:0010780)2.71609628
18Epiphyseal dysplasia (HP:0002656)2.66060554
19Achilles tendon contracture (HP:0001771)2.63299028
20Abnormal number of erythroid precursors (HP:0012131)2.61979551
21Stridor (HP:0010307)2.61875535
22Vertebral compression fractures (HP:0002953)2.60807765
23Short nail (HP:0001799)2.60211678
24Abnormal tarsal ossification (HP:0008369)2.56558094
25Type I transferrin isoform profile (HP:0003642)2.55473744
26Beaking of vertebral bodies (HP:0004568)2.54727482
27Elevated erythrocyte sedimentation rate (HP:0003565)2.53474752
28Dysostosis multiplex (HP:0000943)2.51519815
29Small epiphyses (HP:0010585)2.49823519
30Abnormality of dentin (HP:0010299)2.49640875
31Turricephaly (HP:0000262)2.44363839
32Abnormality of cells of the erythroid lineage (HP:0012130)2.44179694
33Abnormality of fatty-acid metabolism (HP:0004359)2.44084321
34Premature rupture of membranes (HP:0001788)2.43791550
35Abnormality of the intrinsic pathway (HP:0010989)2.43124235
36Abnormality of the Achilles tendon (HP:0005109)2.43101128
37Elbow flexion contracture (HP:0002987)2.42354082
38Coronal craniosynostosis (HP:0004440)2.40293358
39Generalized aminoaciduria (HP:0002909)2.38830011
40Vascular tortuosity (HP:0004948)2.38631241
41Microretrognathia (HP:0000308)2.37374331
42Mucopolysacchariduria (HP:0008155)2.34722786
43Urinary glycosaminoglycan excretion (HP:0003541)2.34722786
44Bladder diverticulum (HP:0000015)2.33355576
45Vacuolated lymphocytes (HP:0001922)2.31042436
46Entropion (HP:0000621)2.29565390
47Biconcave vertebral bodies (HP:0004586)2.28855011
48Hand muscle atrophy (HP:0009130)2.27505134
49Vaginal fistula (HP:0004320)2.27167953
50Spinal rigidity (HP:0003306)2.27122633
51Blue sclerae (HP:0000592)2.26702753
52Premature skin wrinkling (HP:0100678)2.26414584
53Arterial tortuosity (HP:0005116)2.26006646
54Abnormality of the vertebral endplates (HP:0005106)2.25284491
55Abnormality of polysaccharide metabolism (HP:0011012)2.22838642
56Abnormality of glycosaminoglycan metabolism (HP:0004371)2.22838642
57Abnormality of mucopolysaccharide metabolism (HP:0011020)2.22838642
58Cholecystitis (HP:0001082)2.22492213
59Abnormal gallbladder physiology (HP:0012438)2.22492213
60Broad face (HP:0000283)2.21947558
61Hypoplasia of the capital femoral epiphysis (HP:0003090)2.21153798
62J-shaped sella turcica (HP:0002680)2.20259724
63Fragile skin (HP:0001030)2.19472865
64Hemorrhage of the eye (HP:0011885)2.18914828
65Bowing of the arm (HP:0006488)2.18585669
66Bowed forearm bones (HP:0003956)2.18585669
67Platyspondyly (HP:0000926)2.18568003
68Pterygium (HP:0001059)2.18275326
69Shallow orbits (HP:0000586)2.18261975
70Short femoral neck (HP:0100864)2.17109996
71Cerebral hypomyelination (HP:0006808)2.15906055
72Abnormal foot bone ossification (HP:0010675)2.15652713
73Dicarboxylic aciduria (HP:0003215)2.14378870
74Abnormality of dicarboxylic acid metabolism (HP:0010995)2.14378870
75Reticulocytopenia (HP:0001896)2.13971212
76Multiple enchondromatosis (HP:0005701)2.13746939
77Aplastic anemia (HP:0001915)2.13608673
78Squamous cell carcinoma (HP:0002860)2.13161691
79Xanthomatosis (HP:0000991)2.12886912
80Abnormality of endocrine pancreas physiology (HP:0012093)2.11625672
81Abnormality of the pancreatic islet cells (HP:0006476)2.11625672
82Nonimmune hydrops fetalis (HP:0001790)2.08943001
83Abnormality of the distal phalanges of the toes (HP:0010182)2.08581864
84Joint stiffness (HP:0001387)2.07449019
85Anteriorly placed anus (HP:0001545)2.07414359
86Thrombocytosis (HP:0001894)2.06898384
87Cervical subluxation (HP:0003308)2.05966869
88Cerebral aneurysm (HP:0004944)2.05528419
89Ketosis (HP:0001946)2.04285275
90Rough bone trabeculation (HP:0100670)2.04281002
91Distal lower limb muscle weakness (HP:0009053)2.04054461
92Spastic diplegia (HP:0001264)2.02314985
93Irregular epiphyses (HP:0010582)2.01984588
94Abnormal trabecular bone morphology (HP:0100671)1.98446814
95Trismus (HP:0000211)1.97635638
96Hepatic necrosis (HP:0002605)1.96510446
97Opisthotonus (HP:0002179)1.95514727
98Aplasia/Hypoplasia involving the femoral head and neck (HP:0009108)1.95194831
99Facial hemangioma (HP:0000329)1.94664546
100Ankle contracture (HP:0006466)1.93481152
101Cardiovascular calcification (HP:0011915)1.93464643
102Mildly elevated creatine phosphokinase (HP:0008180)1.93021114
103Back pain (HP:0003418)1.93010275
104Poor head control (HP:0002421)1.92342448
105Ketoacidosis (HP:0001993)1.91393484
106Flat acetabular roof (HP:0003180)1.90062540
107Asymmetry of the thorax (HP:0001555)1.89388348
108Carpal bone hypoplasia (HP:0001498)1.89260661
109Hypoplasia of the odontoid process (HP:0003311)1.88684858
110Petechiae (HP:0000967)1.88677942
111Abnormality of the acetabulum (HP:0003170)1.88378188
112Abnormal cartilage morphology (HP:0002763)1.87839739
113Abnormality of the umbilical cord (HP:0010881)1.87741812
114Abnormality of monocarboxylic acid metabolism (HP:0010996)1.87536231
115Mitral regurgitation (HP:0001653)1.86786780
116Intrahepatic cholestasis (HP:0001406)1.86662744
117Abnormality of glycolipid metabolism (HP:0010969)1.86201128
118Abnormality of liposaccharide metabolism (HP:0010968)1.86201128
119Abnormality of glycosphingolipid metabolism (HP:0004343)1.86201128
120Insomnia (HP:0100785)1.86037538
121Wormian bones (HP:0002645)1.85092006
122Spastic paraparesis (HP:0002313)1.83845711
123Degeneration of anterior horn cells (HP:0002398)1.83836657
124Abnormality of the anterior horn cell (HP:0006802)1.83836657
125Episodic fever (HP:0001954)1.83578426
126Myopathic facies (HP:0002058)1.83406806
127Genu recurvatum (HP:0002816)1.83113935
128Distal upper limb amyotrophy (HP:0007149)1.83101193
129Upper limb amyotrophy (HP:0009129)1.83101193
130Vascular calcification (HP:0004934)1.82006397
131Increased muscle lipid content (HP:0009058)1.81977761
132Rectal fistula (HP:0100590)1.80422601
133Rectovaginal fistula (HP:0000143)1.80422601
134Abnormality of carpal bone ossification (HP:0006257)1.80019292
135Abnormal epiphyseal ossification (HP:0010656)1.79451000
136Absent epiphyses (HP:0010577)1.79154462
137Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)1.79154462
138Delayed epiphyseal ossification (HP:0002663)1.78410364
139Soft skin (HP:0000977)1.78281794
140Aortic dissection (HP:0002647)1.78224858
141Progressive neurologic deterioration (HP:0002344)1.77362611
142Distal lower limb amyotrophy (HP:0008944)1.76741983
143Abnormality of the heme biosynthetic pathway (HP:0010472)1.76485911
144Rib fusion (HP:0000902)1.75378054
145Natal tooth (HP:0000695)1.75348284
146Abnormalities of placenta or umbilical cord (HP:0001194)1.74798004
147Aplasia/Hypoplasia of the sacrum (HP:0008517)1.74161606
148Mitral stenosis (HP:0001718)1.73951441
149Generalized amyotrophy (HP:0003700)1.73882021
150Epiphyseal stippling (HP:0010655)1.73759974
151Hepatosplenomegaly (HP:0001433)1.73601610
152Progressive muscle weakness (HP:0003323)1.72913144
153Chronic otitis media (HP:0000389)1.72884155
154Deep venous thrombosis (HP:0002625)1.72683751
155Popliteal pterygium (HP:0009756)1.72557719
156Intestinal fistula (HP:0100819)1.71839275
157Hypobetalipoproteinemia (HP:0003563)1.71065708
158Microglossia (HP:0000171)1.70733476
159Long palpebral fissure (HP:0000637)1.70035946
160Abnormal delivery (HP:0001787)1.69899292
161Osteolytic defects of the phalanges of the hand (HP:0009771)1.69832843
162Osteolytic defects of the hand bones (HP:0009699)1.69832843
163Hyperammonemia (HP:0001987)1.69287456
164Abnormal ossification of hand bones (HP:0005921)1.68775392
165Increased connective tissue (HP:0009025)1.68746119
166Atrophic scars (HP:0001075)1.68558109
167Hypoglycemic seizures (HP:0002173)1.67837789
168Coxa vara (HP:0002812)1.67808265
169Late onset (HP:0003584)1.67086444
170Increased intramyocellular lipid droplets (HP:0012240)1.66414684
171Prolonged partial thromboplastin time (HP:0003645)1.65517155
172Abnormality of the common coagulation pathway (HP:0010990)1.64087134

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BCKDK3.85549883
2ERN13.56635602
3NME23.03254492
4STK162.90214026
5SIK12.77939714
6BUB12.70346919
7EIF2AK32.69047957
8SCYL22.66584832
9SIK32.51215392
10MST1R2.35724324
11TRIB32.31265900
12SMG12.19755995
13ARAF2.10069457
14TESK22.01174617
15LMTK22.00979828
16PIM21.95619430
17PASK1.81250895
18KDR1.77179538
19FLT31.74948471
20EPHA21.72099150
21PDGFRA1.63939537
22VRK21.62571127
23CAMKK21.59946819
24EPHB11.47083141
25PKN21.39311639
26DYRK31.36064530
27BRSK21.35996723
28RPS6KA41.35287860
29TBK11.34583952
30MAP3K101.34432321
31KIT1.29580262
32MAPK151.28845513
33MAPKAPK51.27491060
34WEE11.27166729
35LRRK21.26822420
36PBK1.24592628
37TTN1.24574059
38PRKD21.23705910
39PAK41.22933489
40TAOK21.22784060
41BTK1.18301048
42TESK11.18122383
43EIF2AK11.17442469
44VRK11.16407698
45MAP2K31.09578518
46TLK11.09338496
47RIPK11.08388947
48PRPF4B1.06005231
49MET1.04747426
50CSF1R1.02889881
51LIMK11.02866282
52TGFBR10.99029921
53TGFBR20.97012948
54MAPKAPK30.94364790
55ERBB40.92268417
56ACVR1B0.92154992
57RPS6KB20.89692990
58CLK10.89527716
59STK390.87284461
60NEK20.86196876
61TYK20.83288590
62MAP3K30.83069274
63MAP4K10.81272261
64NTRK10.80602926
65MAP3K80.79703857
66MTOR0.79677411
67IRAK40.78681876
68IRAK20.78465336
69CDC70.78375023
70CDK120.77547309
71CDK70.77232533
72BCR0.76952751
73BRAF0.76684735
74AURKA0.75111898
75BMX0.74897473
76MATK0.74512822
77MAP2K20.73613159
78CAMK1D0.73154548
79JAK30.72408108
80MUSK0.70715425
81PAK20.68932153
82RPS6KA20.67397338
83EPHB20.67277521
84EEF2K0.65092567
85ZAP700.64904313
86FGFR40.64141838
87CDK11A0.63838707
88PIK3CG0.63429340
89MOS0.63142768
90LATS20.62980980
91CDK150.62664293
92ABL20.61911832
93ILK0.60778672
94MAPK110.60190178
95CDK180.59526229
96CDK80.59231997
97IKBKB0.58814824
98DYRK1B0.58596294
99NEK90.58215704
100SRPK10.58067310
101DAPK10.57939958
102STK100.57907885
103DDR20.57849248
104RPS6KA50.57514495
105NEK10.57445124
106MYLK0.55150685
107TAOK10.55080426
108CDK140.54675455
109PTK60.54241249
110BLK0.53767594
111CHUK0.53326659
112AKT20.52590909
113CDK190.52570707
114PDPK10.51760074
115TEC0.51689144
116TNIK0.51507613
117STK40.51429150
118PRKCI0.49359931
119AURKB0.48592829
120MAP3K110.47744873
121GRK60.47633746
122RAF10.47560828
123PAK10.47475795
124CCNB10.47351553
125LYN0.47089159
126IRAK30.45868896
127IKBKE0.45428760
128TAOK30.45061316
129CSNK1G30.44288634
130ICK0.44235054
131KSR20.44154025
132BRSK10.42438215
133PRKD30.41961433
134HIPK20.38123244
135CDK60.37341048
136DYRK20.36844289
137IRAK10.36763378
138ERBB20.36329993
139MARK30.36106036
140CSNK1A1L0.35929925
141CDC42BPA0.35412161
142WNK40.33547546
143CHEK20.33251040
144PRKD10.32985718
145ATR0.32779566
146PTK20.32273450
147MAPKAPK20.31993850
148STK380.31485525
149DAPK30.30228133
150PRKG20.29530803

Predicted pathways (KEGG)

RankGene SetZ-score
1Protein export_Homo sapiens_hsa030603.18060928
2DNA replication_Homo sapiens_hsa030303.13449081
3Fructose and mannose metabolism_Homo sapiens_hsa000513.08073793
4Folate biosynthesis_Homo sapiens_hsa007902.29198019
5Ribosome_Homo sapiens_hsa030102.24569674
6Mismatch repair_Homo sapiens_hsa034302.23469294
7Proteasome_Homo sapiens_hsa030502.15661498
8Base excision repair_Homo sapiens_hsa034102.02812000
9Maturity onset diabetes of the young_Homo sapiens_hsa049502.02246869
10N-Glycan biosynthesis_Homo sapiens_hsa005101.97219016
11Other types of O-glycan biosynthesis_Homo sapiens_hsa005141.84600664
12RNA polymerase_Homo sapiens_hsa030201.83668633
13Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.81138922
14Steroid biosynthesis_Homo sapiens_hsa001001.80185827
15Pyrimidine metabolism_Homo sapiens_hsa002401.74068928
16Central carbon metabolism in cancer_Homo sapiens_hsa052301.73372143
17Sulfur metabolism_Homo sapiens_hsa009201.68569225
18Other glycan degradation_Homo sapiens_hsa005111.68404158
19Fatty acid elongation_Homo sapiens_hsa000621.67785806
20Sulfur relay system_Homo sapiens_hsa041221.63282246
21Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.61985954
22Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.60980684
23Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.59037104
24Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.57554372
25Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.54002494
26Drug metabolism - other enzymes_Homo sapiens_hsa009831.48404503
27Vibrio cholerae infection_Homo sapiens_hsa051101.45734852
28Glycosaminoglycan degradation_Homo sapiens_hsa005311.41235064
29Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.40712620
30Fatty acid degradation_Homo sapiens_hsa000711.38559031
31Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.33171933
32Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.33089875
33Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.31652212
34Primary bile acid biosynthesis_Homo sapiens_hsa001201.28963372
35Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.27790164
36Selenocompound metabolism_Homo sapiens_hsa004501.26958072
37Peroxisome_Homo sapiens_hsa041461.26377704
38Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.25478282
39Glutathione metabolism_Homo sapiens_hsa004801.25454348
40One carbon pool by folate_Homo sapiens_hsa006701.24828751
41Small cell lung cancer_Homo sapiens_hsa052221.21197985
42Lysosome_Homo sapiens_hsa041421.19277654
43Nucleotide excision repair_Homo sapiens_hsa034201.18666838
44Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.18298894
45Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.17563062
46Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.17237714
47Fatty acid metabolism_Homo sapiens_hsa012121.16445617
48Arginine and proline metabolism_Homo sapiens_hsa003301.15363425
49Pentose phosphate pathway_Homo sapiens_hsa000301.14936532
50Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.14705675
51Pentose and glucuronate interconversions_Homo sapiens_hsa000401.13750702
52Caffeine metabolism_Homo sapiens_hsa002321.12046168
53Tryptophan metabolism_Homo sapiens_hsa003801.11124205
54Spliceosome_Homo sapiens_hsa030401.10214578
55Homologous recombination_Homo sapiens_hsa034401.06629117
56Thyroid cancer_Homo sapiens_hsa052161.02097853
57Focal adhesion_Homo sapiens_hsa045101.01288703
58Propanoate metabolism_Homo sapiens_hsa006400.94769645
59Butanoate metabolism_Homo sapiens_hsa006500.93535173
60Biosynthesis of amino acids_Homo sapiens_hsa012300.92435181
61Histidine metabolism_Homo sapiens_hsa003400.90345124
622-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.90338270
63Pyruvate metabolism_Homo sapiens_hsa006200.89839943
64Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.88781045
65Carbon metabolism_Homo sapiens_hsa012000.87796687
66Proteoglycans in cancer_Homo sapiens_hsa052050.87366225
67Prion diseases_Homo sapiens_hsa050200.87090826
68Phenylalanine metabolism_Homo sapiens_hsa003600.86817513
69Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.86693856
70Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.85099153
71Systemic lupus erythematosus_Homo sapiens_hsa053220.82056595
72Cysteine and methionine metabolism_Homo sapiens_hsa002700.79230910
73Hippo signaling pathway_Homo sapiens_hsa043900.78422968
74Tyrosine metabolism_Homo sapiens_hsa003500.75481589
75Pancreatic cancer_Homo sapiens_hsa052120.74938425
76Endometrial cancer_Homo sapiens_hsa052130.74738589
77Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.73995051
78Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.72877813
79Galactose metabolism_Homo sapiens_hsa000520.72444174
80Non-small cell lung cancer_Homo sapiens_hsa052230.71763628
81Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.70724448
82Shigellosis_Homo sapiens_hsa051310.70686850
83Legionellosis_Homo sapiens_hsa051340.70333457
84Cell cycle_Homo sapiens_hsa041100.69794019
85beta-Alanine metabolism_Homo sapiens_hsa004100.67334030
86Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.66731218
87Metabolic pathways_Homo sapiens_hsa011000.65388005
88RNA transport_Homo sapiens_hsa030130.64854530
89Endocytosis_Homo sapiens_hsa041440.63581727
90Purine metabolism_Homo sapiens_hsa002300.60000514
91Fat digestion and absorption_Homo sapiens_hsa049750.59318085
92Antigen processing and presentation_Homo sapiens_hsa046120.57474958
93Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.57088342
94Complement and coagulation cascades_Homo sapiens_hsa046100.56785724
95Thyroid hormone signaling pathway_Homo sapiens_hsa049190.56384973
96AMPK signaling pathway_Homo sapiens_hsa041520.55850808
97Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.55077412
98Acute myeloid leukemia_Homo sapiens_hsa052210.53951611
99Vitamin B6 metabolism_Homo sapiens_hsa007500.53553608
100Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.52603666
101Chemical carcinogenesis_Homo sapiens_hsa052040.51645129
102Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.51043411
103MicroRNAs in cancer_Homo sapiens_hsa052060.50449623
104Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.50148982
105Cyanoamino acid metabolism_Homo sapiens_hsa004600.49874280
106Bladder cancer_Homo sapiens_hsa052190.48879868
107Insulin signaling pathway_Homo sapiens_hsa049100.48828889
108Hepatitis C_Homo sapiens_hsa051600.48281906
109Prostate cancer_Homo sapiens_hsa052150.48279949
110VEGF signaling pathway_Homo sapiens_hsa043700.48231307
111Starch and sucrose metabolism_Homo sapiens_hsa005000.47940969
112Adherens junction_Homo sapiens_hsa045200.47200456
113Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.46919296
114Basal cell carcinoma_Homo sapiens_hsa052170.46240429
115Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.46039522
116Arginine biosynthesis_Homo sapiens_hsa002200.45562827
117Sphingolipid metabolism_Homo sapiens_hsa006000.45451958
118AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.45005513
119Oxidative phosphorylation_Homo sapiens_hsa001900.44803606
120SNARE interactions in vesicular transport_Homo sapiens_hsa041300.44638167
121Vitamin digestion and absorption_Homo sapiens_hsa049770.43952605
122Malaria_Homo sapiens_hsa051440.43880001
123Steroid hormone biosynthesis_Homo sapiens_hsa001400.43089166
124Melanoma_Homo sapiens_hsa052180.43024382
125Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.42466488
126Parkinsons disease_Homo sapiens_hsa050120.42274169
127PI3K-Akt signaling pathway_Homo sapiens_hsa041510.40317553
128mTOR signaling pathway_Homo sapiens_hsa041500.40273159
129Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.40046881
130Epstein-Barr virus infection_Homo sapiens_hsa051690.39924575
131p53 signaling pathway_Homo sapiens_hsa041150.39349099
132Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.38875893
133Hepatitis B_Homo sapiens_hsa051610.37798840
134ECM-receptor interaction_Homo sapiens_hsa045120.37557333
135Regulation of actin cytoskeleton_Homo sapiens_hsa048100.36930278
136Amoebiasis_Homo sapiens_hsa051460.36477509
137Apoptosis_Homo sapiens_hsa042100.36259125
138Viral carcinogenesis_Homo sapiens_hsa052030.36191395
139Hedgehog signaling pathway_Homo sapiens_hsa043400.35502478
140Protein digestion and absorption_Homo sapiens_hsa049740.35440887
141Chronic myeloid leukemia_Homo sapiens_hsa052200.34206683
142HTLV-I infection_Homo sapiens_hsa051660.32796533
143Glioma_Homo sapiens_hsa052140.32386955
144Arachidonic acid metabolism_Homo sapiens_hsa005900.32123519
145Notch signaling pathway_Homo sapiens_hsa043300.31578050
146Lysine degradation_Homo sapiens_hsa003100.31108560

Most similar genes based on co-expression Upload to Enrichr

Tissue Expression Export image »

Cell Line Expression Export image »