SLC35B3

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene is a member of the solute carrier family. The encoded protein is involved in the transport of 3-prime phosphoadenosine 5-prime phosphosulfate (PAPS) from the nucleus or the cytosol to the Golgi lumen. This gene has been reported to be expressed preferentially in the human colon tissues. Alternative splicing results in multiple transcript variants. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1negative regulation of protein localization to plasma membrane (GO:1903077)6.20879727
2negative regulation of establishment of protein localization to plasma membrane (GO:0090005)5.77596854
3antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)5.33481727
4antigen processing and presentation of endogenous peptide antigen (GO:0002483)5.33481727
5positive regulation of gamma-delta T cell activation (GO:0046645)5.16364479
6antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G4.92078806
7antigen processing and presentation of endogenous antigen (GO:0019883)4.55443900
8signal peptide processing (GO:0006465)4.54487169
9negative regulation of leukocyte mediated cytotoxicity (GO:0001911)4.46002553
10negative regulation of cell killing (GO:0031342)4.46002553
11fat-soluble vitamin biosynthetic process (GO:0042362)4.07563382
12Golgi transport vesicle coating (GO:0048200)3.97600920
13COPI coating of Golgi vesicle (GO:0048205)3.97600920
14regulation of isotype switching to IgG isotypes (GO:0048302)3.93235564
15regulation of gamma-delta T cell differentiation (GO:0045586)3.85352327
16negative T cell selection (GO:0043383)3.80781208
17COPII vesicle coating (GO:0048208)3.73925416
18positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)3.71624869
19regulation of gamma-delta T cell activation (GO:0046643)3.70315312
20negative thymic T cell selection (GO:0045060)3.70061983
21regulation of metalloenzyme activity (GO:0048552)3.66339576
22antigen processing and presentation via MHC class Ib (GO:0002475)3.64311830
23response to interferon-beta (GO:0035456)3.58500105
24keratan sulfate catabolic process (GO:0042340)3.56906409
25nucleotide transmembrane transport (GO:1901679)3.49050310
26positive regulation of humoral immune response (GO:0002922)3.38145912
27positive regulation of glycoprotein metabolic process (GO:1903020)3.35249685
28positive regulation of isotype switching (GO:0045830)3.31832600
29definitive hemopoiesis (GO:0060216)3.31765080
30cellular response to interferon-beta (GO:0035458)3.29045391
31regulation of antigen processing and presentation of peptide antigen (GO:0002583)3.28229823
32pyrimidine-containing compound transmembrane transport (GO:0072531)3.27960056
33interferon-gamma production (GO:0032609)3.27831861
34regulation of protein localization to plasma membrane (GO:1903076)3.27657440
35regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)3.27562688
36regulation of B cell receptor signaling pathway (GO:0050855)3.25369794
37Arp2/3 complex-mediated actin nucleation (GO:0034314)3.23739018
38iron ion import (GO:0097286)3.20931388
39transcytosis (GO:0045056)3.18199784
40regulation of cytokine secretion involved in immune response (GO:0002739)3.16956427
41negative regulation of complement activation (GO:0045916)3.16556723
42NIK/NF-kappaB signaling (GO:0038061)3.16405848
43response to type I interferon (GO:0034340)3.16209962
44desmosome organization (GO:0002934)3.15697646
45nucleotide-sugar biosynthetic process (GO:0009226)3.14721178
46regulation of calcineurin-NFAT signaling cascade (GO:0070884)3.14583196
47cellular response to type I interferon (GO:0071357)3.14168777
48type I interferon signaling pathway (GO:0060337)3.14168777
49T cell migration (GO:0072678)3.13919864
50regulation of protein polyubiquitination (GO:1902914)3.13172750
51regulation of RIG-I signaling pathway (GO:0039535)3.12228035
52type B pancreatic cell proliferation (GO:0044342)3.10819450
53daunorubicin metabolic process (GO:0044597)3.08571221
54polyketide metabolic process (GO:0030638)3.08571221
55doxorubicin metabolic process (GO:0044598)3.08571221
56calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules (GO:0016338)3.08273803
57cellular glucuronidation (GO:0052695)3.07821389
58negative regulation of protein activation cascade (GO:2000258)3.07502609
59response to interleukin-15 (GO:0070672)3.07098778
60negative regulation of humoral immune response (GO:0002921)3.05938890
61negative regulation of stress fiber assembly (GO:0051497)3.05454903
62regulation of alpha-beta T cell proliferation (GO:0046640)3.04782506
63positive regulation of interleukin-2 biosynthetic process (GO:0045086)3.04738158
64fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)3.04062038
65regulation of T cell mediated cytotoxicity (GO:0001914)3.02880302
66neutrophil activation involved in immune response (GO:0002283)3.00924811
67regulation of Golgi to plasma membrane protein transport (GO:0042996)2.99935983
68positive regulation of type I interferon-mediated signaling pathway (GO:0060340)2.97722392
69positive regulation of DNA recombination (GO:0045911)2.95078151
70regulation of establishment of protein localization to plasma membrane (GO:0090003)2.94197903
71positive regulation of alpha-beta T cell proliferation (GO:0046641)2.93425950
72mast cell activation (GO:0045576)2.90723546
73cellular response to interleukin-15 (GO:0071350)2.89810737
74phenylpropanoid metabolic process (GO:0009698)2.88696058
75positive regulation of actin filament depolymerization (GO:0030836)2.87815197
76positive regulation of glycoprotein biosynthetic process (GO:0010560)2.86198363
77regulation of response to interferon-gamma (GO:0060330)2.85449803
78positive regulation of B cell mediated immunity (GO:0002714)2.83641222
79positive regulation of immunoglobulin mediated immune response (GO:0002891)2.83641222
80cell adhesion mediated by integrin (GO:0033627)2.81811409
81uronic acid metabolic process (GO:0006063)2.81752275
82glucuronate metabolic process (GO:0019585)2.81752275
83sphingomyelin metabolic process (GO:0006684)2.78240536
84positive regulation of T cell mediated cytotoxicity (GO:0001916)2.77703216
85regulation of T cell receptor signaling pathway (GO:0050856)2.77519071
86regulation of viral-induced cytoplasmic pattern recognition receptor signaling pathway (GO:0039531)2.73632636
87sequestering of extracellular ligand from receptor (GO:0035581)2.72632840
88regulation of interferon-gamma-mediated signaling pathway (GO:0060334)2.72527939
89necroptotic process (GO:0070266)2.72201228
90smooth muscle tissue development (GO:0048745)2.72122824
91organelle membrane fusion (GO:0090174)2.71641680
92autophagic vacuole fusion (GO:0000046)2.71390232
93regulation of interleukin-12 biosynthetic process (GO:0045075)2.70913195
94response to protozoan (GO:0001562)2.69295828
95negative regulation of ryanodine-sensitive calcium-release channel activity (GO:0060315)2.68969931
96diterpenoid biosynthetic process (GO:0016102)2.68802844
97lipoprotein transport (GO:0042953)2.68702837
98defense response to protozoan (GO:0042832)2.67833313
99regulation of antigen receptor-mediated signaling pathway (GO:0050854)2.67530320
100positive regulation of natural killer cell differentiation (GO:0032825)2.66572744
101regulation of necroptotic process (GO:0060544)2.66016947
102regulation of integrin-mediated signaling pathway (GO:2001044)2.65114534
103regulation of isotype switching (GO:0045191)2.64218422
104regulation of transforming growth factor beta1 production (GO:0032908)2.63965500
105amyloid precursor protein catabolic process (GO:0042987)2.61526510
106collagen fibril organization (GO:0030199)2.60761609
107magnesium ion transport (GO:0015693)2.60200138
108T cell selection (GO:0045058)2.59808393
109blood vessel maturation (GO:0001955)2.59060940
110negative regulation of epidermal growth factor-activated receptor activity (GO:0007175)2.58438026
111positive thymic T cell selection (GO:0045059)2.58329067
112Golgi to endosome transport (GO:0006895)2.57872891
113hypotonic response (GO:0006971)2.57842329
114epoxygenase P450 pathway (GO:0019373)2.57592653
115virion attachment to host cell (GO:0019062)2.56470197
116adhesion of symbiont to host cell (GO:0044650)2.56470197
117peptide catabolic process (GO:0043171)2.56312871
118intestinal absorption (GO:0050892)2.55714937
119hyaluronan catabolic process (GO:0030214)2.55540896
120regulation of extracellular matrix disassembly (GO:0010715)2.54768945
121xenobiotic catabolic process (GO:0042178)2.54626953
122extracellular fibril organization (GO:0043206)2.53991133
123regulation of regulatory T cell differentiation (GO:0045589)2.52760806
124regulation of B cell differentiation (GO:0045577)2.52679015
125myeloid dendritic cell activation (GO:0001773)2.52227372
126production of molecular mediator involved in inflammatory response (GO:0002532)2.51623262
127thymic T cell selection (GO:0045061)2.51367655
128chaperone mediated protein folding requiring cofactor (GO:0051085)2.50803077
129nucleotide-sugar metabolic process (GO:0009225)2.50626398
130pinocytosis (GO:0006907)2.50038347
131oligosaccharide biosynthetic process (GO:0009312)2.49185067
132oligosaccharide catabolic process (GO:0009313)2.47576197
133regulation of T cell tolerance induction (GO:0002664)2.47230172
134dendritic cell chemotaxis (GO:0002407)2.46897785
135dendritic cell migration (GO:0036336)2.46842316
136hepatocyte apoptotic process (GO:0097284)2.46400723
137primary alcohol catabolic process (GO:0034310)2.46099137
138T cell receptor signaling pathway (GO:0050852)2.45979127
139regulation of leukocyte mediated cytotoxicity (GO:0001910)2.44675407
140viral protein processing (GO:0019082)2.44598915
141parturition (GO:0007567)2.44230362
142interferon-gamma-mediated signaling pathway (GO:0060333)2.43763566
143regulation of B cell mediated immunity (GO:0002712)2.43758249
144positive regulation of B cell differentiation (GO:0045579)2.43583264
145actin filament depolymerization (GO:0030042)2.43290658
146actin nucleation (GO:0045010)2.43240577
147UDP-N-acetylglucosamine metabolic process (GO:0006047)2.43218685
148regulation of immunoglobulin mediated immune response (GO:0002889)2.41504511
149very-low-density lipoprotein particle assembly (GO:0034379)2.41207762
150negative regulation of antigen receptor-mediated signaling pathway (GO:0050858)2.40319452
151vesicle coating (GO:0006901)2.40043280
152positive regulation of leukocyte mediated cytotoxicity (GO:0001912)2.39783444
153membrane protein ectodomain proteolysis (GO:0006509)2.39766225
154ribosomal small subunit assembly (GO:0000028)2.39752874
155progesterone metabolic process (GO:0042448)2.39273158
156positive regulation of interleukin-8 secretion (GO:2000484)2.39256934
157leukocyte aggregation (GO:0070486)2.38812751
158B cell receptor signaling pathway (GO:0050853)2.38724245
159regulation of interleukin-8 secretion (GO:2000482)2.38403050
160negative regulation of T cell receptor signaling pathway (GO:0050860)2.37970822
161positive T cell selection (GO:0043368)2.37306093
162antigen receptor-mediated signaling pathway (GO:0050851)2.37285609
163early endosome to late endosome transport (GO:0045022)2.36763036
164positive regulation of antigen processing and presentation (GO:0002579)2.35410168
165glycoside metabolic process (GO:0016137)2.35315118
166fibril organization (GO:0097435)2.34776235
167mast cell degranulation (GO:0043303)2.34611575
168mast cell activation involved in immune response (GO:0002279)2.34611575
169cyclooxygenase pathway (GO:0019371)2.34295743
170plasma lipoprotein particle assembly (GO:0034377)2.34139487
171regulation of intracellular pH (GO:0051453)2.33624066
172positive regulation of keratinocyte differentiation (GO:0045618)2.33386290
173positive regulation of respiratory burst (GO:0060267)2.33203517
174retinal metabolic process (GO:0042574)2.32259797
1754-hydroxyproline metabolic process (GO:0019471)2.30621417
176O-glycan processing (GO:0016266)2.30612246
177positive regulation of pseudopodium assembly (GO:0031274)2.28994928
178glutathione derivative biosynthetic process (GO:1901687)2.28685122
179glutathione derivative metabolic process (GO:1901685)2.28685122
180positive regulation of protein autophosphorylation (GO:0031954)2.28030412
181angiotensin maturation (GO:0002003)2.27777714
182regulation of receptor recycling (GO:0001919)2.25478635
183regulation of vitamin metabolic process (GO:0030656)2.20909734
184ethanol oxidation (GO:0006069)2.20644732
185ER to Golgi vesicle-mediated transport (GO:0006888)2.20035328
186retinol metabolic process (GO:0042572)2.19711124
187positive regulation of transforming growth factor beta production (GO:0071636)2.19645834
188regulation of ER to Golgi vesicle-mediated transport (GO:0060628)2.18517091
189membrane protein proteolysis (GO:0033619)2.17996558
190cellular response to vitamin (GO:0071295)2.17933430
191protein-lipid complex assembly (GO:0065005)2.17510597
192protein localization to endosome (GO:0036010)2.16926741
193ethanol metabolic process (GO:0006067)2.16592812
194regulation of collagen metabolic process (GO:0010712)2.16232794
195skin morphogenesis (GO:0043589)2.16163933
196primary alcohol metabolic process (GO:0034308)2.15841085

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1IRF8_22096565_ChIP-ChIP_GC-B_Human4.90725522
2FOXP3_17237761_ChIP-ChIP_TREG_Mouse4.70143066
3IRF8_22096565_ChIP-ChIP_GC-B_Mouse4.02434282
4BP1_19119308_ChIP-ChIP_Hs578T_Human3.35860632
5ELF1_17652178_ChIP-ChIP_JURKAT_Human3.32686820
6E2F7_22180533_ChIP-Seq_HELA_Human3.17825665
7STAT6_20620947_ChIP-Seq_CD4_POS_T_Human3.09925430
8IRF8_21731497_ChIP-ChIP_J774_Mouse3.08010042
9MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.99908143
10* SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse2.95035759
11IRF1_21803131_ChIP-Seq_MONOCYTES_Human2.90101538
12TRIM28_21343339_ChIP-Seq_HEK293_Human2.85271051
13SMAD_19615063_ChIP-ChIP_OVARY_Human2.80252938
14SPI1_22096565_ChIP-ChIP_GC-B_Mouse2.79634807
15STAT4_19710469_ChIP-ChIP_TH1__Mouse2.50684860
16GATA1_22025678_ChIP-Seq_K562_Human2.50605481
17FLI1_20887958_ChIP-Seq_HPC-7_Mouse2.39576047
18RUNX1_20887958_ChIP-Seq_HPC-7_Mouse2.37763989
19TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse2.33727972
20WT1_19549856_ChIP-ChIP_CCG9911_Human2.31587408
21SMAD4_19686287_ChIP-ChIP_HaCaT_Human2.29726116
22RUNX_20019798_ChIP-Seq_JUKART_Human2.22691430
23BRD4_25478319_ChIP-Seq_HGPS_Human2.14809358
24MYB_26560356_Chip-Seq_TH2_Human2.14212755
25NRF2_20460467_ChIP-Seq_MEFs_Mouse2.14079929
26NFE2L2_20460467_ChIP-Seq_MEFs_Mouse2.14079929
27* SPI1_23547873_ChIP-Seq_NB4_Human2.09856612
28CEBPA_23403033_ChIP-Seq_LIVER_Mouse2.08965845
29CDX2_19796622_ChIP-Seq_MESCs_Mouse2.08867566
30GABP_17652178_ChIP-ChIP_JURKAT_Human2.06894963
31STAT3_20064451_ChIP-Seq_CD4+T_Mouse2.06467213
32HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.05869861
33ERG_20887958_ChIP-Seq_HPC-7_Mouse2.04848842
34IRF8_27001747_Chip-Seq_BMDM_Mouse2.03664179
35NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse2.02151735
36SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.98754308
37ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.97639493
38TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.94735221
39HOXB4_20404135_ChIP-ChIP_EML_Mouse1.93580554
40* FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.93226233
41MYB_21317192_ChIP-Seq_ERMYB_Mouse1.88918554
42CJUN_26792858_Chip-Seq_BT549_Human1.88871422
43GATA2_21666600_ChIP-Seq_HMVEC_Human1.86912445
44SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.85621532
45FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.85588649
46SCL_19346495_ChIP-Seq_HPC-7_Human1.81935437
47SOX2_20726797_ChIP-Seq_SW620_Human1.81272208
48FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human1.80125246
49CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.79215545
50NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.78759863
51MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.78451359
52MYB_26560356_Chip-Seq_TH1_Human1.76673105
53* POU3F2_20337985_ChIP-ChIP_501MEL_Human1.74813372
54EST1_17652178_ChIP-ChIP_JURKAT_Human1.73226976
55STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.71008510
56* CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.70895340
57JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.70226024
58ELK1_19687146_ChIP-ChIP_HELA_Human1.68994756
59VDR_23849224_ChIP-Seq_CD4+_Human1.67664316
60PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.65064454
61EGR1_19374776_ChIP-ChIP_THP-1_Human1.64401421
62* PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.63791118
63* SRF_21415370_ChIP-Seq_HL-1_Mouse1.62673989
64FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human1.60950010
65SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.58586945
66PCGF2_27294783_Chip-Seq_ESCs_Mouse1.58488411
67LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.58269900
68EZH2_27294783_Chip-Seq_NPCs_Mouse1.58229901
69GATA4_25053715_ChIP-Seq_YYC3_Human1.56930946
70CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.55510564
71SALL4_18804426_ChIP-ChIP_XEN_Mouse1.55279243
72GFI1B_20887958_ChIP-Seq_HPC-7_Mouse1.55216134
73FLI1_27457419_Chip-Seq_LIVER_Mouse1.55150350
74NOTCH1_21737748_ChIP-Seq_TLL_Human1.54829692
75MAF_26560356_Chip-Seq_TH1_Human1.54455598
76RUNX1_22412390_ChIP-Seq_EML_Mouse1.54195276
77FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.53680823
78EGR1_23403033_ChIP-Seq_LIVER_Mouse1.53057475
79KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.52228549
80* CDX2_22108803_ChIP-Seq_LS180_Human1.49812419
81CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.49356016
82EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.48581299
83FOXP3_21729870_ChIP-Seq_TREG_Human1.47647969
84* GATA2_22383799_ChIP-Seq_G1ME_Mouse1.47313686
85SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.46407215
86SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.46407215
87PPAR_26484153_Chip-Seq_NCI-H1993_Human1.45944887
88MYC_22102868_ChIP-Seq_BL_Human1.41484608
89LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.41304172
90RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.40565122
91* PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.39877811
92TP53_18474530_ChIP-ChIP_U2OS_Human1.39391874
93TP63_23658742_ChIP-Seq_EP156T_Human1.37703463
94SUZ12_27294783_Chip-Seq_NPCs_Mouse1.36468425
95AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.36389403
96NFE2_27457419_Chip-Seq_LIVER_Mouse1.32975771
97GATA1_22383799_ChIP-Seq_G1ME_Mouse1.31067786
98PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.30364992
99PIAS1_25552417_ChIP-Seq_VCAP_Human1.29903179
100EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.29070392
101BRD4_27068464_Chip-Seq_AML-cells_Mouse1.28649151
102BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.28580774
103FOXM1_26456572_ChIP-Seq_MCF-7_Human1.27552834
104E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.27036684
105TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.26253587
106VDR_24763502_ChIP-Seq_THP-1_Human1.25953310
107GATA3_27048872_Chip-Seq_THYMUS_Human1.24970749
108SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.24413740
109UTX_26944678_Chip-Seq_JUKART_Human1.23837714
110DCP1A_22483619_ChIP-Seq_HELA_Human1.23738295
111RXR_22158963_ChIP-Seq_LIVER_Mouse1.23169898
112HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.22954224
113CIITA_25753668_ChIP-Seq_RAJI_Human1.22474624
114SOX2_27498859_Chip-Seq_STOMACH_Mouse1.22294344
115ZFP57_27257070_Chip-Seq_ESCs_Mouse1.21977230
116CRX_20693478_ChIP-Seq_RETINA_Mouse1.21569739
117ETS1_20019798_ChIP-Seq_JURKAT_Human1.21090859
118VDR_21846776_ChIP-Seq_THP-1_Human1.20884341
119TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.20830277
120SUZ12_18555785_Chip-Seq_ESCs_Mouse1.19100856
121PCGF2_27294783_Chip-Seq_NPCs_Mouse1.18886150
122HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.18837768
123SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.17469190
124TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.17067204
125RARG_19884340_ChIP-ChIP_MEFs_Mouse1.16679309
126GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.16147174
127P53_22387025_ChIP-Seq_ESCs_Mouse1.15539835
128STAT3_18555785_Chip-Seq_ESCs_Mouse1.14311343
129E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.13987632
130GATA3_26560356_Chip-Seq_TH2_Human1.13919755
131TFEB_21752829_ChIP-Seq_HELA_Human1.13299851
132CREB1_15753290_ChIP-ChIP_HEK293T_Human1.12068614
133SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse1.11646363
134MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.11393903
135ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.10585442
136Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.10354565
137CMYC_18555785_Chip-Seq_ESCs_Mouse1.10210128
138* E2F1_18555785_ChIP-Seq_MESCs_Mouse1.09568517
139CLOCK_20551151_ChIP-Seq_293T_Human1.09547647
140* GABP_19822575_ChIP-Seq_HepG2_Human1.08841482
141CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.08081597
142RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.08048114
143CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.08037638
144NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.07412154
145* PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.07307698
146E2F1_18555785_Chip-Seq_ESCs_Mouse1.06448481
147LXR_22158963_ChIP-Seq_LIVER_Mouse1.06037692
148NANOG_18555785_Chip-Seq_ESCs_Mouse1.05979610
149ZNF217_24962896_ChIP-Seq_MCF-7_Human1.04971292
150SMAD1_18555785_Chip-Seq_ESCs_Mouse1.04713310
151CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.04497002
152PU_27001747_Chip-Seq_BMDM_Mouse1.04003870
153MYC_18358816_ChIP-ChIP_MESCs_Mouse1.03637656
154HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.03332326
155OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.02566056
156MAF_26560356_Chip-Seq_TH2_Human1.02440534
157NELFA_20434984_ChIP-Seq_ESCs_Mouse1.02315915
158FOXO3_23340844_ChIP-Seq_DLD1_Human1.02229973
159P300_18555785_Chip-Seq_ESCs_Mouse1.01993423
160CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse1.01317496
161SOX2_18555785_Chip-Seq_ESCs_Mouse1.01248322
162CDX2_20551321_ChIP-Seq_CACO-2_Human1.01143203
163SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.00809323
164E2F4_17652178_ChIP-ChIP_JURKAT_Human1.00668468
165ELF5_23300383_ChIP-Seq_T47D_Human1.00596169
166SPI1_23127762_ChIP-Seq_K562_Human1.00411983
167MYC_18555785_ChIP-Seq_MESCs_Mouse0.99618375
168TCF4_18268006_ChIP-ChIP_LS174T_Human0.99197647
169CEBPB_24764292_ChIP-Seq_MC3T3_Mouse0.99168421
170BCAT_22108803_ChIP-Seq_LS180_Human0.98414861
171OCT4_21477851_ChIP-Seq_ESCs_Mouse0.98353524
172NMYC_18555785_Chip-Seq_ESCs_Mouse0.98005076
173* GATA3_24758297_ChIP-Seq_MCF-7_Human0.97754002
174OCT4_18555785_Chip-Seq_ESCs_Mouse0.97642035
175CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse0.96566347
176CHD1_19587682_ChIP-ChIP_MESCs_Mouse0.94578872
177FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human0.93828053
178PPARA_22158963_ChIP-Seq_LIVER_Mouse0.88543090

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008438_abnormal_cutaneous_collagen5.21856398
2MP0003724_increased_susceptibility_to3.85837706
3MP0001835_abnormal_antigen_presentation3.24708103
4MP0000685_abnormal_immune_system3.24355350
5MP0003763_abnormal_thymus_physiology3.08211979
6MP0005671_abnormal_response_to2.94634297
7MP0009785_altered_susceptibility_to2.80171281
8MP0005275_abnormal_skin_tensile2.79206651
9MP0005000_abnormal_immune_tolerance2.58179712
10MP0003436_decreased_susceptibility_to2.57987198
11MP0004272_abnormal_basement_membrane2.52218816
12MP0001800_abnormal_humoral_immune2.46760893
13MP0003950_abnormal_plasma_membrane2.46708275
14MP0005387_immune_system_phenotype2.42779479
15MP0001790_abnormal_immune_system2.42779479
16MP0003866_abnormal_defecation2.36545675
17MP0002396_abnormal_hematopoietic_system2.34314086
18MP0003279_aneurysm2.33288489
19MP0001873_stomach_inflammation2.32899618
20MP0002723_abnormal_immune_serum2.31681377
21MP0003941_abnormal_skin_development2.30493770
22MP0006082_CNS_inflammation2.26684477
23MP0005058_abnormal_lysosome_morphology2.22257970
24MP0002420_abnormal_adaptive_immunity2.19967064
25MP0005025_abnormal_response_to2.19564840
26MP0001819_abnormal_immune_cell2.17936140
27MP0002452_abnormal_antigen_presenting2.17270413
28MP0005503_abnormal_tendon_morphology2.16303556
29MP0002148_abnormal_hypersensitivity_rea2.14568046
30MP0010352_gastrointestinal_tract_polyps2.09701614
31MP0005257_abnormal_intraocular_pressure2.07861881
32MP0002398_abnormal_bone_marrow2.06636796
33MP0002166_altered_tumor_susceptibility1.98814413
34MP0002419_abnormal_innate_immunity1.96473167
35MP0009333_abnormal_splenocyte_physiolog1.96240578
36MP0010155_abnormal_intestine_physiology1.96124174
37MP0002102_abnormal_ear_morphology1.95076937
38MP0010234_abnormal_vibrissa_follicle1.90910724
39MP0000716_abnormal_immune_system1.88036742
40MP0002139_abnormal_hepatobiliary_system1.84521858
41MP0001542_abnormal_bone_strength1.84444080
42MP0000465_gastrointestinal_hemorrhage1.76297725
43MP0000689_abnormal_spleen_morphology1.75433128
44MP0002405_respiratory_system_inflammati1.74796932
45MP0005464_abnormal_platelet_physiology1.74347382
46MP0005075_abnormal_melanosome_morpholog1.71023163
47MP0001958_emphysema1.70864779
48MP0006054_spinal_hemorrhage1.68887935
49MP0009384_cardiac_valve_regurgitation1.67142496
50MP0002722_abnormal_immune_system1.66751936
51MP0001845_abnormal_inflammatory_respons1.66342488
52MP0002429_abnormal_blood_cell1.65325254
53MP0005084_abnormal_gallbladder_morpholo1.61783904
54MP0002933_joint_inflammation1.55055825
55MP0002138_abnormal_hepatobiliary_system1.50146876
56MP0008875_abnormal_xenobiotic_pharmacok1.49339297
57MP0008469_abnormal_protein_level1.48212704
58MP0005365_abnormal_bile_salt1.46779694
59MP0003943_abnormal_hepatobiliary_system1.46072700
60MP0004947_skin_inflammation1.43002449
61MP0005165_increased_susceptibility_to1.42451125
62MP0000371_diluted_coat_color1.42340665
63MP0005310_abnormal_salivary_gland1.42195499
64MP0004808_abnormal_hematopoietic_stem1.41874608
65MP0001533_abnormal_skeleton_physiology1.40850834
66MP0002006_tumorigenesis1.39936626
67MP0008260_abnormal_autophagy1.39406842
68MP0000703_abnormal_thymus_morphology1.39003798
69MP0000490_abnormal_crypts_of1.38406000
70MP0003806_abnormal_nucleotide_metabolis1.37201246
71MP0002060_abnormal_skin_morphology1.35474447
72MP0005023_abnormal_wound_healing1.32393885
73MP0010368_abnormal_lymphatic_system1.30724921
74MP0000013_abnormal_adipose_tissue1.28333851
75MP0003656_abnormal_erythrocyte_physiolo1.26087572
76MP0003191_abnormal_cellular_cholesterol1.25232683
77MP0005332_abnormal_amino_acid1.24879148
78MP0004147_increased_porphyrin_level1.24572671
79MP0009780_abnormal_chondrocyte_physiolo1.22847794
80MP0003300_gastrointestinal_ulcer1.22668039
81MP0002295_abnormal_pulmonary_circulatio1.21069896
82MP0003186_abnormal_redox_activity1.16328749
83MP0005164_abnormal_response_to1.15508228
84MP0000858_altered_metastatic_potential1.15477024
85MP0005360_urolithiasis1.14723052
86MP0004019_abnormal_vitamin_homeostasis1.12898556
87MP0000767_abnormal_smooth_muscle1.12228722
88MP0004484_altered_response_of1.11544083
89MP0010386_abnormal_urinary_bladder1.10617754
90MP0001545_abnormal_hematopoietic_system1.09955035
91MP0005397_hematopoietic_system_phenotyp1.09955035
92MP0000462_abnormal_digestive_system1.09649913
93MP0005174_abnormal_tail_pigmentation1.07230920
94MP0003091_abnormal_cell_migration1.06353105
95MP0002896_abnormal_bone_mineralization1.06181180
96MP0001853_heart_inflammation1.05725250
97MP0003183_abnormal_peptide_metabolism1.00555550
98MP0001243_abnormal_dermal_layer1.00298303
99MP0003566_abnormal_cell_adhesion0.99930556
100MP0009764_decreased_sensitivity_to0.99399430
101MP0002693_abnormal_pancreas_physiology0.98283986
102MP0010094_abnormal_chromosome_stability0.96149560
103MP0005220_abnormal_exocrine_pancreas0.96140387
104MP0009840_abnormal_foam_cell0.94038638
105MP0003172_abnormal_lysosome_physiology0.93958483
106MP0001666_abnormal_nutrient_absorption0.93901370
107MP0001756_abnormal_urination0.93606303
108MP0008007_abnormal_cellular_replicative0.93269055
109MP0009763_increased_sensitivity_to0.92419073
110MP0009643_abnormal_urine_homeostasis0.91288768
111MP0010329_abnormal_lipoprotein_level0.90893504
112MP0002168_other_aberrant_phenotype0.90420955
113MP0009765_abnormal_xenobiotic_induced0.89767719
114MP0005367_renal/urinary_system_phenotyp0.88716630
115MP0000516_abnormal_urinary_system0.88716630
116MP0000609_abnormal_liver_physiology0.88588126
117MP0009697_abnormal_copulation0.87853422
118MP0000343_altered_response_to0.87656271
119MP0002019_abnormal_tumor_incidence0.87137954
120MP0003705_abnormal_hypodermis_morpholog0.86912294
121MP0005085_abnormal_gallbladder_physiolo0.86485080
122MP0008004_abnormal_stomach_pH0.86435324
123MP0000372_irregular_coat_pigmentation0.85953123
124MP0004043_abnormal_pH_regulation0.85869066
125MP0005083_abnormal_biliary_tract0.83787147
126MP0005451_abnormal_body_composition0.83592798
127MP0000015_abnormal_ear_pigmentation0.82928702
128MP0003252_abnormal_bile_duct0.82341284
129MP0005508_abnormal_skeleton_morphology0.81923891
130MP0002132_abnormal_respiratory_system0.81745877
131MP0005623_abnormal_meninges_morphology0.81074838
132MP0000598_abnormal_liver_morphology0.79264456
133MP0001764_abnormal_homeostasis0.78680723
134MP0005171_absent_coat_pigmentation0.78679825
135MP0003303_peritoneal_inflammation0.77577884
136MP0004134_abnormal_chest_morphology0.77537301
137MP0004883_abnormal_blood_vessel0.76582351
138MP0003868_abnormal_feces_composition0.75427815
139MP0001879_abnormal_lymphatic_vessel0.75234361
140MP0009379_abnormal_foot_pigmentation0.75166458
141MP0000358_abnormal_cell_content/0.74779459
142MP0008873_increased_physiological_sensi0.74222921
143MP0005636_abnormal_mineral_homeostasis0.74095417
144MP0002928_abnormal_bile_duct0.73543390
145MP0000569_abnormal_digit_pigmentation0.73334129
146MP0001663_abnormal_digestive_system0.72722097
147MP0003693_abnormal_embryo_hatching0.72269678
148MP0005319_abnormal_enzyme/_coenzyme0.72187776
149MP0002136_abnormal_kidney_physiology0.70467658
150MP0006035_abnormal_mitochondrial_morpho0.70422373
151MP0003195_calcinosis0.70316313
152MP0005408_hypopigmentation0.70183437
153MP0001348_abnormal_lacrimal_gland0.70142589
154MP0001661_extended_life_span0.70084527
155MP0005390_skeleton_phenotype0.69817422
156MP0003795_abnormal_bone_structure0.69687605
157MP0002998_abnormal_bone_remodeling0.68952694
158MP0002877_abnormal_melanocyte_morpholog0.67551243
159MP0003828_pulmonary_edema0.65519086

Predicted human phenotypes

RankGene SetZ-score
1Premature rupture of membranes (HP:0001788)4.70722322
2Abnormality of T cell number (HP:0011839)3.98516531
3T lymphocytopenia (HP:0005403)3.80514765
4Elevated erythrocyte sedimentation rate (HP:0003565)3.75767228
5Myositis (HP:0100614)3.74342008
6Tetraparesis (HP:0002273)3.71880503
7Thrombocytosis (HP:0001894)3.69981421
8Cervical subluxation (HP:0003308)3.69670288
9Vacuolated lymphocytes (HP:0001922)3.60061026
10Autoimmune thrombocytopenia (HP:0001973)3.58264670
11Autoimmune hemolytic anemia (HP:0001890)3.56017199
12IgM deficiency (HP:0002850)3.47786039
13Increased neuronal autofluorescent lipopigment (HP:0002074)3.47465039
14Follicular hyperkeratosis (HP:0007502)3.43912962
15Abnormality of T cells (HP:0002843)3.41816458
16Generalized aminoaciduria (HP:0002909)3.30152998
17Mucopolysacchariduria (HP:0008155)3.29078370
18Urinary glycosaminoglycan excretion (HP:0003541)3.29078370
19Aortic dissection (HP:0002647)3.29036179
20Cardiovascular calcification (HP:0011915)3.21727302
21Orchitis (HP:0100796)3.20796644
22Abnormality of mucopolysaccharide metabolism (HP:0011020)3.20759336
23Abnormality of polysaccharide metabolism (HP:0011012)3.20759336
24Abnormality of glycosaminoglycan metabolism (HP:0004371)3.20759336
25Retrobulbar optic neuritis (HP:0100654)3.18546281
26Optic neuritis (HP:0100653)3.18546281
27Chronic otitis media (HP:0000389)3.18103019
28Protrusio acetabuli (HP:0003179)3.17431356
29Increased IgM level (HP:0003496)3.14732202
30Peritonitis (HP:0002586)3.08739703
31Petechiae (HP:0000967)3.06428130
32Recurrent viral infections (HP:0004429)3.05283608
33Type I transferrin isoform profile (HP:0003642)3.04901980
34Recurrent bronchitis (HP:0002837)3.04725510
35Abnormality of T cell physiology (HP:0011840)2.99281645
36Severe combined immunodeficiency (HP:0004430)2.95453177
37Increased cerebral lipofuscin (HP:0011813)2.92510896
38Recurrent fungal infections (HP:0002841)2.83118891
39Hyperlipoproteinemia (HP:0010980)2.82631355
40Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)2.81440012
41Mitral stenosis (HP:0001718)2.81009962
42Hydroxyprolinuria (HP:0003080)2.80288729
43Abnormality of proline metabolism (HP:0010907)2.80288729
44Abnormality of B cell number (HP:0010975)2.80211387
45B lymphocytopenia (HP:0010976)2.80211387
46Combined immunodeficiency (HP:0005387)2.79286411
47Chronic diarrhea (HP:0002028)2.79022300
48Ovoid vertebral bodies (HP:0003300)2.78953907
49Recurrent abscess formation (HP:0002722)2.78600160
50Abnormality of glutamine family amino acid metabolism (HP:0010902)2.78493222
51Abnormal delayed hypersensitivity skin test (HP:0002963)2.75369181
52Vascular tortuosity (HP:0004948)2.73742211
53Vascular calcification (HP:0004934)2.73161746
54Epistaxis (HP:0000421)2.70828306
55Vasculitis (HP:0002633)2.70633235
56Nonimmune hydrops fetalis (HP:0001790)2.70007218
57Abnormality of eosinophils (HP:0001879)2.69750537
58Metaphyseal dysplasia (HP:0100255)2.69663104
59Eczematoid dermatitis (HP:0000976)2.68840788
60IgG deficiency (HP:0004315)2.68812145
61Eosinophilia (HP:0001880)2.63732337
62Joint swelling (HP:0001386)2.62136680
63Leukocytosis (HP:0001974)2.58275780
64Albinism (HP:0001022)2.57698495
65Recurrent bacterial skin infections (HP:0005406)2.56842719
66Intrahepatic cholestasis (HP:0001406)2.55965419
67Abnormal glycosylation (HP:0012345)2.52848548
68Abnormal isoelectric focusing of serum transferrin (HP:0003160)2.52848548
69Abnormal protein N-linked glycosylation (HP:0012347)2.52848548
70Abnormal protein glycosylation (HP:0012346)2.52848548
71Hypoplasia of the thymus (HP:0000778)2.52801221
72Granulocytopenia (HP:0001913)2.52361048
73Abnormality of aromatic amino acid family metabolism (HP:0004338)2.52101449
74Hand muscle atrophy (HP:0009130)2.51994057
75Reduced antithrombin III activity (HP:0001976)2.51646194
76Thyroiditis (HP:0100646)2.50958775
77Atrophic scars (HP:0001075)2.50287077
78Symptomatic seizures (HP:0011145)2.48490459
79Fat malabsorption (HP:0002630)2.46527274
80Abnormality of monocarboxylic acid metabolism (HP:0010996)2.42720582
81Arterial tortuosity (HP:0005116)2.40597478
82Keratoconjunctivitis sicca (HP:0001097)2.38872498
83Gingival bleeding (HP:0000225)2.38742279
84Panhypogammaglobulinemia (HP:0003139)2.38507315
85Aortic aneurysm (HP:0004942)2.36668317
86Soft skin (HP:0000977)2.36075760
87Encephalitis (HP:0002383)2.31220491
88Dilatation of the ascending aorta (HP:0005111)2.31071503
893-Methylglutaconic aciduria (HP:0003535)2.30629817
90Abnormality of cells of the lymphoid lineage (HP:0012140)2.29367172
91Abnormality of macrophages (HP:0004311)2.28379331
92Recurrent gram-negative bacterial infections (HP:0005420)2.28116196
93Lymphoma (HP:0002665)2.27079843
94Arterial thrombosis (HP:0004420)2.25947954
95Patchy hypopigmentation of hair (HP:0011365)2.24983271
96Lymphopenia (HP:0001888)2.24664471
97Impaired platelet aggregation (HP:0003540)2.22998824
98Abnormal platelet function (HP:0011869)2.22998824
99Glucose intolerance (HP:0000833)2.22640014
100Orthostatic hypotension (HP:0001278)2.21902890
101Prolonged bleeding time (HP:0003010)2.21725903
102Prolonged partial thromboplastin time (HP:0003645)2.20719825
103Entropion (HP:0000621)2.19101276
104IgA deficiency (HP:0002720)2.18194359
105Meningitis (HP:0001287)2.16811464
106Steatorrhea (HP:0002570)2.16696229
107Abnormality of dentin (HP:0010299)2.14847052
108Neutropenia (HP:0001875)2.14566392
109Hyperalaninemia (HP:0003348)2.14507996
110Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.14507996
111Abnormality of alanine metabolism (HP:0010916)2.14507996
112Keratoconjunctivitis (HP:0001096)2.13366441
113Amaurosis fugax (HP:0100576)2.13356724
114Right ventricular cardiomyopathy (HP:0011663)2.11602717
115Spondylolisthesis (HP:0003302)2.10720827
116Dysostosis multiplex (HP:0000943)2.10130348
117Recurrent skin infections (HP:0001581)2.08838112
118Abnormality of the prostate (HP:0008775)2.08011506
119Aplastic anemia (HP:0001915)2.05607485
120Hypergammaglobulinemia (HP:0010702)2.05053316
121Beaking of vertebral bodies (HP:0004568)2.04532562
122Nasal polyposis (HP:0100582)2.02038370
123Abnormality of pyrimidine metabolism (HP:0004353)2.01835874
124Gastrointestinal stroma tumor (HP:0100723)2.01537998
125Hypothermia (HP:0002045)2.01273415
126Abnormality of glycolipid metabolism (HP:0010969)2.01247620
127Abnormality of liposaccharide metabolism (HP:0010968)2.01247620
128Abnormality of glycosphingolipid metabolism (HP:0004343)2.01247620
129Blue sclerae (HP:0000592)2.00621079
130Upper limb amyotrophy (HP:0009129)1.99239967
131Distal upper limb amyotrophy (HP:0007149)1.99239967
132Pustule (HP:0200039)1.97852223
133Cutaneous melanoma (HP:0012056)1.97569213
134Pulmonary infiltrates (HP:0002113)1.97109884
135Increased CSF protein (HP:0002922)1.96566912
136Bronchitis (HP:0012387)1.96236577
137Mediastinal lymphadenopathy (HP:0100721)1.95006789
138Xanthomatosis (HP:0000991)1.92694947
139Osteolytic defects of the hand bones (HP:0009699)1.91616269
140Osteolytic defects of the phalanges of the hand (HP:0009771)1.91616269
141Microretrognathia (HP:0000308)1.91540237
142Recurrent cutaneous fungal infections (HP:0011370)1.91522579
143Chronic mucocutaneous candidiasis (HP:0002728)1.91522579
144Large eyes (HP:0001090)1.90869773
145Myocardial infarction (HP:0001658)1.90133787
14611 pairs of ribs (HP:0000878)1.89039418
147Tongue fasciculations (HP:0001308)1.88684279
148Posterior subcapsular cataract (HP:0007787)1.88376749
149Spontaneous hematomas (HP:0007420)1.88341793
150Joint hemorrhage (HP:0005261)1.88304214
151Aortic valve stenosis (HP:0001650)1.88118308
152Chondrocalcinosis (HP:0000934)1.86777157
153Fatigue (HP:0012378)1.86118806
154Nausea (HP:0002018)1.85716325
155Hemoptysis (HP:0002105)1.85357002
156Periodontitis (HP:0000704)1.84990428
157Broad face (HP:0000283)1.83845846
158Abnormality of the nasal mucosa (HP:0000433)1.83757389
159Increased corneal curvature (HP:0100692)1.83536181
160Keratoconus (HP:0000563)1.83536181
161Abnormality of vitamin B metabolism (HP:0004340)1.81900668
162Respiratory insufficiency due to defective ciliary clearance (HP:0200073)1.81156892
163Abnormality of fatty-acid metabolism (HP:0004359)1.80547653
164Abnormal glucose tolerance (HP:0001952)1.80191798
165Recurrent pneumonia (HP:0006532)1.80041126
166Hyperactive renin-angiotensin system (HP:0000841)1.79697975
167Abnormality of the intrinsic pathway (HP:0010989)1.79587208
168Wormian bones (HP:0002645)1.79377507
169Neoplasm of head and neck (HP:0012288)1.78769675
170White forelock (HP:0002211)1.78479256
171Hematochezia (HP:0002573)1.78162609
172Upper motor neuron abnormality (HP:0002127)1.76542246
173Alopecia of scalp (HP:0002293)1.76196789
174Abnormality of vitamin metabolism (HP:0100508)1.75305094
175Abnormality of Sharpey fibers (HP:0100685)1.75304569
176Abnormality of carpal bone ossification (HP:0006257)1.74945220
177Abnormality of the level of lipoprotein cholesterol (HP:0010979)1.73937227
178Abnormality of the acetabulum (HP:0003170)1.73818993
179Syringomyelia (HP:0003396)1.69705786
180Spinal cord lesions (HP:0100561)1.69705786
181Fragile skin (HP:0001030)1.69332480
182Ankle contracture (HP:0006466)1.68563424
183Loss of speech (HP:0002371)1.68190427
184Muscle fibrillation (HP:0010546)1.68162561
185Delayed gross motor development (HP:0002194)1.68151193
186Dry hair (HP:0011359)1.68106352
187Hypoalphalipoproteinemia (HP:0003233)1.66007970
188Vertebral compression fractures (HP:0002953)1.65997948
189Abnormality of small intestinal villus morphology (HP:0011472)1.65906776
190Villous atrophy (HP:0011473)1.65906776

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MUSK3.83440750
2TIE13.82773224
3MAP4K13.45283249
4TXK3.41780868
5TEC3.10946491
6MAP3K143.00432175
7MYLK2.65934192
8STK392.63751308
9ACVR1B2.49340375
10IRAK42.49211177
11TAOK32.45261916
12ERBB32.44474167
13ZAP702.44458255
14ADRBK22.36528515
15LATS12.33747729
16BLK2.30784747
17JAK32.28102385
18ITK2.22095793
19TBK12.21108313
20DDR22.19087649
21INSRR2.17107697
22PDK22.08966359
23FLT32.00611592
24IKBKE1.99190416
25KIT1.95230564
26TYK21.95165442
27MAP3K41.86785275
28MAP3K21.85223659
29MAPKAPK31.85045886
30BTK1.78337422
31MAP3K31.71278547
32TRIM281.70935304
33STK101.65616020
34ERN11.64250238
35PIM21.58977570
36JAK11.48837628
37IKBKB1.48825516
38LIMK11.46505749
39FER1.46315372
40PIK3CG1.46198699
41STK31.43020828
42EIF2AK31.42408957
43BMPR1B1.41724455
44PDGFRA1.40234140
45MST1R1.39421211
46BMPR21.38675618
47TGFBR11.37191542
48NME21.36890257
49BRSK21.33894224
50PAK41.33314867
51MAP3K131.32325701
52MET1.28911907
53OXSR11.24331673
54KDR1.24317037
55SYK1.22875033
56SCYL21.21861854
57FGFR41.21616021
58LCK1.19264933
59BCR1.17245725
60PBK1.17188080
61GRK71.15207058
62CSK1.12381866
63CSF1R1.11471688
64NLK1.09635856
65GRK61.08726363
66AKT31.07612416
67TGFBR21.06547526
68EPHA21.06160224
69NUAK11.05548708
70WNK31.04700885
71PTK2B1.03160184
72LMTK21.01238976
73IRAK31.00707979
74LYN0.99785085
75PASK0.95008651
76ABL20.93073480
77TRPM70.91763834
78PRKCQ0.89887124
79PLK20.87578635
80PTK20.85511889
81PIM10.84116191
82CHUK0.82083390
83STK160.82030356
84PRKCE0.81760283
85EIF2AK10.81410148
86LRRK20.80949027
87RPS6KA40.80540201
88VRK10.79674328
89PLK40.77992450
90CLK10.76241934
91ERBB40.76151653
92MAP2K70.73552668
93CASK0.72496618
94PRKG20.71735233
95TESK20.69263249
96ADRBK10.68368603
97CDK60.67335334
98FRK0.66947889
99PINK10.65656106
100ABL10.64523816
101ILK0.63298188
102WNK40.62658627
103HCK0.61774750
104STK38L0.61380709
105NEK10.59565735
106BUB10.58101237
107MAP3K120.55169459
108MATK0.54318123
109CAMKK20.53640783
110MST40.53221562
111STK240.52803772
112SIK30.50510029
113MAP3K50.49883776
114RIPK40.48923333
115MAPKAPK20.48337817
116IRAK10.46537461
117MAP2K20.46413996
118PAK20.46379275
119MELK0.45066700
120MAP3K70.44634376
121TSSK60.44326805
122MAP3K60.43089451
123PAK30.41110469
124GRK10.40953978
125MAPK110.40505443
126FGFR30.38932482
127MOS0.38736344
128BCKDK0.35994039
129IGF1R0.35270229
130JAK20.34287981
131YES10.33813708
132RPS6KA60.33425945
133MARK30.33343741
134TESK10.32604860
135PTK60.32508771
136PRKCD0.32371326
137PDGFRB0.31984792
138CCNB10.31827607
139MAPK30.31814828
140CDK80.30647354
141PRKD10.28719559
142NEK90.27811258
143EPHA30.27176964
144ROCK20.26942503
145MAP3K100.25774099
146PIK3CA0.25089242
147GSK3A0.24580396
148IRAK20.24109351
149RPS6KC10.23821491
150RPS6KL10.23821491
151ATR0.23667024
152EIF2AK20.23267820
153FES0.23130322
154DYRK30.21381431
155CSNK1G30.20951923
156MAP2K30.20503918

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary immunodeficiency_Homo sapiens_hsa053403.25561662
2Protein export_Homo sapiens_hsa030603.00972243
3Intestinal immune network for IgA production_Homo sapiens_hsa046722.65507319
4Allograft rejection_Homo sapiens_hsa053302.60698099
5Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009802.37767575
6Chemical carcinogenesis_Homo sapiens_hsa052042.36380957
7Drug metabolism - cytochrome P450_Homo sapiens_hsa009822.26118956
8Inflammatory bowel disease (IBD)_Homo sapiens_hsa053212.18210123
9Cytosolic DNA-sensing pathway_Homo sapiens_hsa046232.15471983
10Antigen processing and presentation_Homo sapiens_hsa046122.13122445
11NF-kappa B signaling pathway_Homo sapiens_hsa040642.11478790
12Measles_Homo sapiens_hsa051622.08187037
13Graft-versus-host disease_Homo sapiens_hsa053322.03844382
14Ascorbate and aldarate metabolism_Homo sapiens_hsa000532.00144240
15Folate biosynthesis_Homo sapiens_hsa007901.99299538
16Maturity onset diabetes of the young_Homo sapiens_hsa049501.97763457
17Fatty acid elongation_Homo sapiens_hsa000621.96349944
18Leishmaniasis_Homo sapiens_hsa051401.87790722
19Base excision repair_Homo sapiens_hsa034101.86681369
20Retinol metabolism_Homo sapiens_hsa008301.77203141
21Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.72493172
22RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.65671299
23Non-homologous end-joining_Homo sapiens_hsa034501.63848479
24Steroid hormone biosynthesis_Homo sapiens_hsa001401.63714168
25Other glycan degradation_Homo sapiens_hsa005111.62572678
26Fatty acid degradation_Homo sapiens_hsa000711.62344493
27T cell receptor signaling pathway_Homo sapiens_hsa046601.61704215
28Herpes simplex infection_Homo sapiens_hsa051681.58632969
29Fat digestion and absorption_Homo sapiens_hsa049751.56030455
30Caffeine metabolism_Homo sapiens_hsa002321.55328398
31Glutathione metabolism_Homo sapiens_hsa004801.52729723
32DNA replication_Homo sapiens_hsa030301.50314850
33Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.47711451
34Hematopoietic cell lineage_Homo sapiens_hsa046401.47558184
35Ribosome_Homo sapiens_hsa030101.46282792
36Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.43703257
37Autoimmune thyroid disease_Homo sapiens_hsa053201.41772862
38Starch and sucrose metabolism_Homo sapiens_hsa005001.36717936
39Legionellosis_Homo sapiens_hsa051341.36431250
40B cell receptor signaling pathway_Homo sapiens_hsa046621.33715465
41SNARE interactions in vesicular transport_Homo sapiens_hsa041301.31987613
42Arachidonic acid metabolism_Homo sapiens_hsa005901.31937177
43Selenocompound metabolism_Homo sapiens_hsa004501.30414539
44Jak-STAT signaling pathway_Homo sapiens_hsa046301.25992925
45Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.25091032
46NOD-like receptor signaling pathway_Homo sapiens_hsa046211.22745282
47Proteasome_Homo sapiens_hsa030501.21700706
48Toll-like receptor signaling pathway_Homo sapiens_hsa046201.19843365
49Mineral absorption_Homo sapiens_hsa049781.18541962
50Protein digestion and absorption_Homo sapiens_hsa049741.18366470
51Vibrio cholerae infection_Homo sapiens_hsa051101.17569085
52Influenza A_Homo sapiens_hsa051641.15315607
53Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.13234988
54Shigellosis_Homo sapiens_hsa051311.12006869
55Type I diabetes mellitus_Homo sapiens_hsa049401.10845625
56Osteoclast differentiation_Homo sapiens_hsa043801.10425909
57Rheumatoid arthritis_Homo sapiens_hsa053231.09378361
58Tyrosine metabolism_Homo sapiens_hsa003501.08423657
59Apoptosis_Homo sapiens_hsa042101.07049708
60Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.06565419
61Toxoplasmosis_Homo sapiens_hsa051451.06384811
62Steroid biosynthesis_Homo sapiens_hsa001001.06211605
63Ether lipid metabolism_Homo sapiens_hsa005651.06013655
64Sulfur metabolism_Homo sapiens_hsa009201.05924151
65Malaria_Homo sapiens_hsa051441.04653187
66Drug metabolism - other enzymes_Homo sapiens_hsa009831.03989681
67Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.03134567
68Mismatch repair_Homo sapiens_hsa034301.02875073
69Homologous recombination_Homo sapiens_hsa034401.00873104
70ECM-receptor interaction_Homo sapiens_hsa045121.00040127
71beta-Alanine metabolism_Homo sapiens_hsa004100.99439453
72Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.99060014
73Amoebiasis_Homo sapiens_hsa051460.97800672
74Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.97347851
75Hepatitis C_Homo sapiens_hsa051600.94959629
76Vitamin digestion and absorption_Homo sapiens_hsa049770.93561367
77Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.93144935
78Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.92996440
79PPAR signaling pathway_Homo sapiens_hsa033200.92498057
80Cyanoamino acid metabolism_Homo sapiens_hsa004600.92488163
81Pentose and glucuronate interconversions_Homo sapiens_hsa000400.92247015
82Pertussis_Homo sapiens_hsa051330.92019922
83Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.88769489
84Lysosome_Homo sapiens_hsa041420.88753699
85Staphylococcus aureus infection_Homo sapiens_hsa051500.88556150
86Propanoate metabolism_Homo sapiens_hsa006400.87381426
87TNF signaling pathway_Homo sapiens_hsa046680.86910029
88Peroxisome_Homo sapiens_hsa041460.85442279
89Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.85275199
90Pyrimidine metabolism_Homo sapiens_hsa002400.84814011
91Renin-angiotensin system_Homo sapiens_hsa046140.84648465
92Linoleic acid metabolism_Homo sapiens_hsa005910.84186730
93Hepatitis B_Homo sapiens_hsa051610.84113088
94RNA degradation_Homo sapiens_hsa030180.84111976
95Regulation of autophagy_Homo sapiens_hsa041400.82219837
96Acute myeloid leukemia_Homo sapiens_hsa052210.81432574
97ABC transporters_Homo sapiens_hsa020100.81062409
98Collecting duct acid secretion_Homo sapiens_hsa049660.80819759
99Nucleotide excision repair_Homo sapiens_hsa034200.80556917
100Galactose metabolism_Homo sapiens_hsa000520.77774456
101Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.76633311
102Nitrogen metabolism_Homo sapiens_hsa009100.74413356
103Epstein-Barr virus infection_Homo sapiens_hsa051690.74179753
104Fatty acid metabolism_Homo sapiens_hsa012120.73611738
105Leukocyte transendothelial migration_Homo sapiens_hsa046700.73270600
106Tryptophan metabolism_Homo sapiens_hsa003800.71557950
107Arginine biosynthesis_Homo sapiens_hsa002200.67961469
108Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.67799580
109Basal transcription factors_Homo sapiens_hsa030220.67569356
110Tuberculosis_Homo sapiens_hsa051520.67241409
111Salmonella infection_Homo sapiens_hsa051320.66357700
112alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.65759184
113Glycosaminoglycan degradation_Homo sapiens_hsa005310.65613745
114Phenylalanine metabolism_Homo sapiens_hsa003600.64189482
115Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.64164942
116Primary bile acid biosynthesis_Homo sapiens_hsa001200.63711386
117RNA polymerase_Homo sapiens_hsa030200.63266129
118Phagosome_Homo sapiens_hsa041450.63078913
119Thyroid cancer_Homo sapiens_hsa052160.62398049
120Focal adhesion_Homo sapiens_hsa045100.61335676
121Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.60414280
122Viral carcinogenesis_Homo sapiens_hsa052030.59425413
123Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.57964080
124Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.57248823
125Proteoglycans in cancer_Homo sapiens_hsa052050.56634550
126Histidine metabolism_Homo sapiens_hsa003400.56249260
127Chemokine signaling pathway_Homo sapiens_hsa040620.55575852
128Endocytosis_Homo sapiens_hsa041440.55434661
129Complement and coagulation cascades_Homo sapiens_hsa046100.55104340
130Platelet activation_Homo sapiens_hsa046110.55089798
131Sphingolipid metabolism_Homo sapiens_hsa006000.54380597
132Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.53051446
133Sulfur relay system_Homo sapiens_hsa041220.53022337
134Viral myocarditis_Homo sapiens_hsa054160.51846058
135Transcriptional misregulation in cancer_Homo sapiens_hsa052020.51471739
136Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.51470046
137Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.51438222
138Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.50500002
139p53 signaling pathway_Homo sapiens_hsa041150.50414760
140Small cell lung cancer_Homo sapiens_hsa052220.50409441
141Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.50220008
142Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.49239936
143Asthma_Homo sapiens_hsa053100.48884616
144AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.47603640
145N-Glycan biosynthesis_Homo sapiens_hsa005100.47446424
146Glycerophospholipid metabolism_Homo sapiens_hsa005640.47106503
147HTLV-I infection_Homo sapiens_hsa051660.46038290
148Metabolic pathways_Homo sapiens_hsa011000.43704534
149Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.42015092
150Spliceosome_Homo sapiens_hsa030400.41178048
151Arginine and proline metabolism_Homo sapiens_hsa003300.39134082
152One carbon pool by folate_Homo sapiens_hsa006700.38679142
153Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.38675146
154Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.38569082
155Insulin resistance_Homo sapiens_hsa049310.38562404
156Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.29858051
157PI3K-Akt signaling pathway_Homo sapiens_hsa041510.28912441
158Butanoate metabolism_Homo sapiens_hsa006500.28123152

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