SLC35B4

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: Glycosyltransferases, such as SLC35B4, transport nucleotide sugars from the cytoplasm where they are synthesized, to the Golgi apparatus where they are utilized in the synthesis of glycoproteins, glycolipids, and proteoglycans (Ashikov et al., 2005 [PubMed 15911612]). NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1COPI coating of Golgi vesicle (GO:0048205)6.72905227
2Golgi transport vesicle coating (GO:0048200)6.72905227
3protein maturation by protein folding (GO:0022417)5.28764024
4synaptic vesicle maturation (GO:0016188)4.49402813
5beta-amyloid metabolic process (GO:0050435)4.49267640
6synaptic vesicle docking involved in exocytosis (GO:0016081)4.44531918
7maintenance of protein localization in endoplasmic reticulum (GO:0035437)4.22052130
8retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)4.01054052
9aminoglycoside antibiotic metabolic process (GO:0030647)3.89972249
10protein retention in ER lumen (GO:0006621)3.83858088
11glycoside metabolic process (GO:0016137)3.82291305
12drug transmembrane transport (GO:0006855)3.72360899
13sodium ion export (GO:0071436)3.68896662
14positive regulation of calcium ion-dependent exocytosis (GO:0045956)3.63481825
15pyrimidine nucleobase catabolic process (GO:0006208)3.57000922
16valine metabolic process (GO:0006573)3.51897260
17endosome to melanosome transport (GO:0035646)3.50354428
18endosome to pigment granule transport (GO:0043485)3.50354428
19establishment of integrated proviral latency (GO:0075713)3.48459026
20synaptic vesicle exocytosis (GO:0016079)3.46037928
21glutamate secretion (GO:0014047)3.45674636
22activation of signaling protein activity involved in unfolded protein response (GO:0006987)3.41868460
23chromatin remodeling at centromere (GO:0031055)3.36599206
24cellular potassium ion homeostasis (GO:0030007)3.34603325
25regulation of synaptic vesicle exocytosis (GO:2000300)3.28574141
26vesicle coating (GO:0006901)3.28264195
27regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway (GO:19022353.27512305
28locomotory exploration behavior (GO:0035641)3.26756120
29positive regulation of nuclease activity (GO:0032075)3.24693736
30antigen processing and presentation via MHC class Ib (GO:0002475)3.23063295
31activation of protein kinase A activity (GO:0034199)3.18653719
32regulation of short-term neuronal synaptic plasticity (GO:0048172)3.17643422
33oxaloacetate metabolic process (GO:0006107)3.16430646
34regulation of synaptic vesicle transport (GO:1902803)3.16402962
35urate metabolic process (GO:0046415)3.12898962
36regulation of ARF protein signal transduction (GO:0032012)3.12592348
37glucocorticoid receptor signaling pathway (GO:0042921)3.11735706
38CENP-A containing nucleosome assembly (GO:0034080)3.10397160
39positive regulation of excitatory postsynaptic membrane potential (GO:2000463)3.09551184
40L-serine metabolic process (GO:0006563)3.08702429
41proline transport (GO:0015824)3.08118820
42DNA replication checkpoint (GO:0000076)3.07230249
43DNA damage response, detection of DNA damage (GO:0042769)3.05560662
44negative regulation of sodium ion transport (GO:0010766)3.02766826
45toxin transport (GO:1901998)3.01683375
46drug transport (GO:0015893)3.01216638
47adenosine receptor signaling pathway (GO:0001973)3.01213048
48cell communication by electrical coupling involved in cardiac conduction (GO:0086064)2.95392040
49regulation of nuclease activity (GO:0032069)2.92969120
50DNA strand elongation involved in DNA replication (GO:0006271)2.92933286
51DNA unwinding involved in DNA replication (GO:0006268)2.89625707
52mitotic sister chromatid cohesion (GO:0007064)2.89322536
53tricarboxylic acid metabolic process (GO:0072350)2.88129838
54cullin deneddylation (GO:0010388)2.86707095
55organic cation transport (GO:0015695)2.85578882
56non-recombinational repair (GO:0000726)2.85370491
57double-strand break repair via nonhomologous end joining (GO:0006303)2.85370491
58endoplasmic reticulum unfolded protein response (GO:0030968)2.84236918
59regulation of Arp2/3 complex-mediated actin nucleation (GO:0034315)2.82765633
60cellular sodium ion homeostasis (GO:0006883)2.81582436
61DNA strand elongation (GO:0022616)2.80558109
62cellular response to unfolded protein (GO:0034620)2.80462144
63fucose metabolic process (GO:0006004)2.78803184
64protein localization to kinetochore (GO:0034501)2.78145955
65mitotic metaphase plate congression (GO:0007080)2.77257364
66fructose metabolic process (GO:0006000)2.75894690
67presynaptic membrane assembly (GO:0097105)2.75518423
68histone exchange (GO:0043486)2.75161293
69cytokine production involved in immune response (GO:0002367)2.74605508
70regulation of synapse structural plasticity (GO:0051823)2.74287008
71nuclear pore organization (GO:0006999)2.73923864
72cellular response to topologically incorrect protein (GO:0035967)2.73780669
73somatic hypermutation of immunoglobulin genes (GO:0016446)2.73493100
74somatic diversification of immune receptors via somatic mutation (GO:0002566)2.73493100
75regulation of helicase activity (GO:0051095)2.71375597
76peptide catabolic process (GO:0043171)2.71243436
77antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)2.71237716
78antigen processing and presentation of endogenous peptide antigen (GO:0002483)2.71237716
79insulin secretion (GO:0030073)2.71123384
80neurotransmitter secretion (GO:0007269)2.70307478
81presynaptic membrane organization (GO:0097090)2.70104298
82nucleobase catabolic process (GO:0046113)2.70096585
83negative regulation of phosphoprotein phosphatase activity (GO:0032515)2.70017456
84mannose metabolic process (GO:0006013)2.68678460
85neurotransmitter-gated ion channel clustering (GO:0072578)2.68631764
86lysine catabolic process (GO:0006554)2.68415691
87lysine metabolic process (GO:0006553)2.68415691
88positive regulation of lamellipodium assembly (GO:0010592)2.68338435
89sister chromatid segregation (GO:0000819)2.67230170
90DNA double-strand break processing (GO:0000729)2.66926963
91mitotic sister chromatid segregation (GO:0000070)2.65369156
92nuclear pore complex assembly (GO:0051292)2.65083633
93keratan sulfate catabolic process (GO:0042340)2.64875652
94DNA ligation (GO:0006266)2.64392981
95protein N-linked glycosylation via asparagine (GO:0018279)2.63931610
96regulation of attachment of spindle microtubules to kinetochore (GO:0051988)2.63571708
97protein deneddylation (GO:0000338)2.63544157
98negative regulation of DNA-dependent DNA replication (GO:2000104)2.63343885
99positive regulation of membrane potential (GO:0045838)2.63258172
100peptidyl-asparagine modification (GO:0018196)2.61805964
101ER-nucleus signaling pathway (GO:0006984)2.61649705
102alanine transport (GO:0032328)2.59578990
103positive regulation of synaptic transmission, glutamatergic (GO:0051968)2.58140277
104type B pancreatic cell development (GO:0003323)2.57466090
105axonal fasciculation (GO:0007413)2.56938359
106regulation of translational termination (GO:0006449)2.56413906
107DNA replication-independent nucleosome assembly (GO:0006336)2.55875508
108DNA replication-independent nucleosome organization (GO:0034724)2.55875508
109innervation (GO:0060384)2.55838119
110telomere maintenance via semi-conservative replication (GO:0032201)2.54051139
111kinetochore organization (GO:0051383)2.53186878
112necroptotic process (GO:0070266)2.52341406
113chaperone-mediated protein transport (GO:0072321)2.51926990
114histone H2A acetylation (GO:0043968)2.49004410
115cell communication by electrical coupling (GO:0010644)2.48345970
116regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)2.46435502
117heparin metabolic process (GO:0030202)2.45176229
118heparin biosynthetic process (GO:0030210)2.45176229
119nucleotide-excision repair, DNA gap filling (GO:0006297)2.45158524
120negative regulation of norepinephrine secretion (GO:0010700)2.45142437
121regulation of defense response to virus by virus (GO:0050690)2.44994711
122metaphase plate congression (GO:0051310)2.43990377
123positive regulation of synaptic transmission, GABAergic (GO:0032230)2.43487992
124purine nucleobase biosynthetic process (GO:0009113)2.41238322
125establishment of viral latency (GO:0019043)2.41237442
126cellular response to glucagon stimulus (GO:0071377)2.40388535
127negative regulation of amyloid precursor protein catabolic process (GO:1902992)2.40228976
128protein localization to chromosome, centromeric region (GO:0071459)2.40095270
129heparan sulfate proteoglycan biosynthetic process (GO:0015012)2.39233129
130ER-associated ubiquitin-dependent protein catabolic process (GO:0030433)2.39211586
131regulation of centriole replication (GO:0046599)2.39181090
132protein K6-linked ubiquitination (GO:0085020)2.38912686
133retinal ganglion cell axon guidance (GO:0031290)2.38830373
134postsynaptic membrane organization (GO:0001941)2.37919846
135protein N-linked glycosylation (GO:0006487)2.37797105
136tRNA aminoacylation (GO:0043039)2.36199702
137amino acid activation (GO:0043038)2.36199702
138negative regulation of DNA recombination (GO:0045910)2.36070094
139spindle checkpoint (GO:0031577)2.35769319
140regulation of glutamate receptor signaling pathway (GO:1900449)2.35618356
141neuron cell-cell adhesion (GO:0007158)2.35585634
142neuron recognition (GO:0008038)2.35537502
143tRNA aminoacylation for protein translation (GO:0006418)2.34927675
144regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)2.34797676
145regulation of mitotic spindle checkpoint (GO:1903504)2.34797676
146kinetochore assembly (GO:0051382)2.34639472
147establishment of protein localization to mitochondrial membrane (GO:0090151)2.33684962
148positive regulation of dendritic spine morphogenesis (GO:0061003)2.32761569
149resolution of meiotic recombination intermediates (GO:0000712)2.32414983
150growth hormone receptor signaling pathway (GO:0060396)2.32013574
151IMP biosynthetic process (GO:0006188)2.31866374
152ATP-dependent chromatin remodeling (GO:0043044)2.30323577
153cell volume homeostasis (GO:0006884)2.29781132
154branched-chain amino acid metabolic process (GO:0009081)2.29721885
155positive regulation of vesicle fusion (GO:0031340)2.29130542
156phosphate ion transport (GO:0006817)2.28610332
157exocrine pancreas development (GO:0031017)2.28559726
158signal peptide processing (GO:0006465)2.28461848
159UDP-N-acetylglucosamine metabolic process (GO:0006047)2.28389136
160cerebellar Purkinje cell layer development (GO:0021680)2.27942564
161intraciliary transport (GO:0042073)2.27621044
162phosphatidylglycerol biosynthetic process (GO:0006655)2.27298000
163regulation of mitochondrial translation (GO:0070129)2.27252113
164gonadal mesoderm development (GO:0007506)2.26888805
165maintenance of protein localization in organelle (GO:0072595)2.26835859
166galactose catabolic process (GO:0019388)2.26118516
167intra-S DNA damage checkpoint (GO:0031573)2.25891897
168nucleobase biosynthetic process (GO:0046112)2.25201081
169replication fork processing (GO:0031297)2.24930537
170axon extension involved in axon guidance (GO:0048846)2.21734906
171neuron projection extension involved in neuron projection guidance (GO:1902284)2.21734906
172DNA replication-dependent nucleosome assembly (GO:0006335)2.21604455
173DNA replication-dependent nucleosome organization (GO:0034723)2.21604455
174proteasome assembly (GO:0043248)2.21546783
175maturation of 5.8S rRNA (GO:0000460)2.21355703
176negative regulation of chromosome segregation (GO:0051985)2.21024814
177mitotic spindle checkpoint (GO:0071174)2.21022488
178water-soluble vitamin biosynthetic process (GO:0042364)2.20814581
179regulation of double-strand break repair via homologous recombination (GO:0010569)2.20351853
180mitotic recombination (GO:0006312)2.19585772
181DNA replication initiation (GO:0006270)2.19116042
182negative regulation of mitotic metaphase/anaphase transition (GO:0045841)2.18687491
183negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)2.18687491
184negative regulation of mitotic sister chromatid segregation (GO:0033048)2.18687491
185negative regulation of mitotic sister chromatid separation (GO:2000816)2.18687491
186negative regulation of sister chromatid segregation (GO:0033046)2.18687491
187synapsis (GO:0007129)2.15268926
188translesion synthesis (GO:0019985)2.15109107
189serine family amino acid biosynthetic process (GO:0009070)2.15090032
190microtubule depolymerization (GO:0007019)2.13962963
191regulation of nuclear cell cycle DNA replication (GO:0033262)2.13808893
192maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)2.13799601
193protein localization to synapse (GO:0035418)2.13319613
194postreplication repair (GO:0006301)2.12969263
195pre-miRNA processing (GO:0031054)2.12886146
196regulation of chromosome segregation (GO:0051983)2.11612938
197regulation of DNA endoreduplication (GO:0032875)2.11368446
198telomere maintenance via recombination (GO:0000722)2.10183695
199mitotic spindle organization (GO:0007052)2.09958561
200mitochondrial RNA metabolic process (GO:0000959)2.09183418

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human4.99473169
2KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.14379327
3GATA1_22025678_ChIP-Seq_K562_Human3.13202116
4STAT6_20620947_ChIP-Seq_CD4_POS_T_Human2.91025729
5E2F4_17652178_ChIP-ChIP_JURKAT_Human2.84199605
6GBX2_23144817_ChIP-Seq_PC3_Human2.76787897
7NR4A2_19515692_ChIP-ChIP_MN9D_Mouse2.76582434
8SALL1_21062744_ChIP-ChIP_HESCs_Human2.75271338
9SMAD_19615063_ChIP-ChIP_OVARY_Human2.62180186
10IGF1R_20145208_ChIP-Seq_DFB_Human2.45789312
11MYC_18555785_ChIP-Seq_MESCs_Mouse2.43961413
12FOXM1_23109430_ChIP-Seq_U2OS_Human2.42844393
13MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.39860096
14MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.39732258
15SPI1_23127762_ChIP-Seq_K562_Human2.37677593
16GABP_17652178_ChIP-ChIP_JURKAT_Human2.30649399
17* EST1_17652178_ChIP-ChIP_JURKAT_Human2.23691996
18HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.21492969
19* RUNX1_20887958_ChIP-Seq_HPC-7_Mouse2.20044980
20DROSHA_22980978_ChIP-Seq_HELA_Human2.18805115
21* HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.15944711
22RARB_27405468_Chip-Seq_BRAIN_Mouse2.15861203
23KDM5B_21448134_ChIP-Seq_MESCs_Mouse2.09084164
24ZFP322A_24550733_ChIP-Seq_MESCs_Mouse2.08068318
25EZH2_22144423_ChIP-Seq_EOC_Human2.07330521
26SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human2.06731620
27CREB1_15753290_ChIP-ChIP_HEK293T_Human2.00095658
28ZNF274_21170338_ChIP-Seq_K562_Hela1.97899635
29EGR1_19374776_ChIP-ChIP_THP-1_Human1.91863255
30NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.90208969
31CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.87685819
32IRF8_21731497_ChIP-ChIP_J774_Mouse1.87429384
33FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.86676109
34IKZF1_21737484_ChIP-ChIP_HCT116_Human1.86155149
35EWS_26573619_Chip-Seq_HEK293_Human1.85333248
36ELF1_17652178_ChIP-ChIP_JURKAT_Human1.84892988
37ELK1_19687146_ChIP-ChIP_HELA_Human1.80327303
38FUS_26573619_Chip-Seq_HEK293_Human1.79794306
39SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.78387818
40* ETS1_20019798_ChIP-Seq_JURKAT_Human1.75451843
41SCL_19346495_ChIP-Seq_HPC-7_Human1.74937035
42* THAP11_20581084_ChIP-Seq_MESCs_Mouse1.72336089
43PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.72147687
44JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.72064991
45* LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.71933253
46RXR_22108803_ChIP-Seq_LS180_Human1.71018077
47NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.67164878
48IRF8_27001747_Chip-Seq_BMDM_Mouse1.66279614
49YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.65505594
50NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.65279250
51POU5F1_16153702_ChIP-ChIP_HESCs_Human1.64455501
52GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.63988262
53SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.63945241
54* HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.63867889
55ZFP57_27257070_Chip-Seq_ESCs_Mouse1.63680204
56E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.63160934
57NR3C1_23031785_ChIP-Seq_PC12_Mouse1.58424809
58ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.56965772
59* MYC_19030024_ChIP-ChIP_MESCs_Mouse1.56847113
60POU3F2_20337985_ChIP-ChIP_501MEL_Human1.54601822
61MYC_18940864_ChIP-ChIP_HL60_Human1.50506407
62MYC_22102868_ChIP-Seq_BL_Human1.49473309
63TFEB_21752829_ChIP-Seq_HELA_Human1.48723580
64TAF15_26573619_Chip-Seq_HEK293_Human1.48584095
65GATA1_19941827_ChIP-Seq_MEL_Mouse1.48206532
66* MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.47985653
67* DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.47740850
68NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.46615756
69GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.45924262
70E2F1_21310950_ChIP-Seq_MCF-7_Human1.45447745
71SOX2_16153702_ChIP-ChIP_HESCs_Human1.43401680
72E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.42122823
73ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.40740918
74* LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.39633958
75MYC_19079543_ChIP-ChIP_MESCs_Mouse1.38729629
76MYB_21317192_ChIP-Seq_ERMYB_Mouse1.38634722
77MYC_18358816_ChIP-ChIP_MESCs_Mouse1.37531132
78MYCN_18555785_ChIP-Seq_MESCs_Mouse1.35534383
79AR_21909140_ChIP-Seq_LNCAP_Human1.35071677
80* TTF2_22483619_ChIP-Seq_HELA_Human1.33760160
81VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.32168914
82MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.32148518
83* SMAD4_21799915_ChIP-Seq_A2780_Human1.32138107
84CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.28609415
85P300_19829295_ChIP-Seq_ESCs_Human1.28063411
86NELFA_20434984_ChIP-Seq_ESCs_Mouse1.27370466
87STAT3_23295773_ChIP-Seq_U87_Human1.26341416
88RUNX_20019798_ChIP-Seq_JUKART_Human1.26323599
89SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.26165212
90GATA3_26560356_Chip-Seq_TH2_Human1.26151483
91IRF8_22096565_ChIP-ChIP_GC-B_Human1.26106883
92* REST_18959480_ChIP-ChIP_MESCs_Mouse1.26017048
93CTBP1_25329375_ChIP-Seq_LNCAP_Human1.25693065
94HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.24020505
95FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.23119512
96* GABP_19822575_ChIP-Seq_HepG2_Human1.22843578
97* GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.22694708
98MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.21734688
99PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.21270633
100VDR_24787735_ChIP-Seq_THP-1_Human1.21058992
101VDR_22108803_ChIP-Seq_LS180_Human1.20057554
102* E2F1_18555785_ChIP-Seq_MESCs_Mouse1.19720192
103PADI4_21655091_ChIP-ChIP_MCF-7_Human1.19715580
104XRN2_22483619_ChIP-Seq_HELA_Human1.18402811
105TCF7_22412390_ChIP-Seq_EML_Mouse1.17968786
106WT1_25993318_ChIP-Seq_PODOCYTE_Human1.17766983
107MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.17040826
108* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.16918088
109NANOG_16153702_ChIP-ChIP_HESCs_Human1.16906913
110GFI1B_20887958_ChIP-Seq_HPC-7_Mouse1.16815725
111POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.16262819
112CTNNB1_20460455_ChIP-Seq_HCT116_Human1.16179784
113MTF2_20144788_ChIP-Seq_MESCs_Mouse1.15952830
114FOXP3_21729870_ChIP-Seq_TREG_Human1.15049765
115DCP1A_22483619_ChIP-Seq_HELA_Human1.14968384
116ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.14670048
117RNF2_27304074_Chip-Seq_NSC_Mouse1.14536527
118PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.13084383
119PU_27001747_Chip-Seq_BMDM_Mouse1.12586454
120TP63_19390658_ChIP-ChIP_HaCaT_Human1.12039568
121GATA1_26923725_Chip-Seq_HPCs_Mouse1.11780298
122IRF1_19129219_ChIP-ChIP_H3396_Human1.11771519
123GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.10820262
124MYB_26560356_Chip-Seq_TH2_Human1.10570086
125* RUNX1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.10401795
126GATA1_19941826_ChIP-Seq_K562_Human1.10385231
127POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.09857668
128CBX2_27304074_Chip-Seq_ESCs_Mouse1.09551104
129SOX9_26525672_Chip-Seq_HEART_Mouse1.09519748
130* SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.08698475
131EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.07482425
132TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.07129428
133CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.06317676
134CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.06174558
135SOX2_21211035_ChIP-Seq_LN229_Gbm1.05894178
136SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.05772800
137SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.05334593
138SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.05236825
139VDR_23849224_ChIP-Seq_CD4+_Human1.03972355
140RUNX1_22412390_ChIP-Seq_EML_Mouse1.03749969
141RBPJ_22232070_ChIP-Seq_NCS_Mouse1.03729604
142REST_21632747_ChIP-Seq_MESCs_Mouse1.03629229
143CLOCK_20551151_ChIP-Seq_293T_Human1.03190690
144TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.02626876
145YY1_21170310_ChIP-Seq_MESCs_Mouse1.02438055
146FLI1_27457419_Chip-Seq_LIVER_Mouse1.00713260
147MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.00678951
148SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.00083054
149FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse0.99536306
150PIAS1_25552417_ChIP-Seq_VCAP_Human0.99518546
151TCF7L2_21901280_ChIP-Seq_H4IIE_Rat0.99446121
152SOX2_18555785_ChIP-Seq_MESCs_Mouse0.99323528
153MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse0.98933291
154CDX2_19796622_ChIP-Seq_MESCs_Mouse0.98329647
155FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse0.98251211
156NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human0.98068698
157DNAJC2_21179169_ChIP-ChIP_NT2_Human0.97998062
158OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.97496441
159WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse0.97114923
160GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.95585884
161SPI1_23547873_ChIP-Seq_NB4_Human0.94748601
162SOX2_19030024_ChIP-ChIP_MESCs_Mouse0.94623228
163GATA3_27048872_Chip-Seq_THYMUS_Human0.94350712
164CREM_20920259_ChIP-Seq_GC1-SPG_Mouse0.93179405
165CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse0.92471523
166TET1_21490601_ChIP-Seq_MESCs_Mouse0.92310245
167BMI1_23680149_ChIP-Seq_NPCS_Mouse0.91800731
168VDR_24763502_ChIP-Seq_THP-1_Human0.91628959
169* TBX3_20139965_ChIP-Seq_ESCs_Mouse0.91368167
170ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.91218886
171* TBX3_20139965_ChIP-Seq_MESCs_Mouse0.91030698
172CTBP2_25329375_ChIP-Seq_LNCAP_Human0.89930450
173KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse0.89913163
174NANOG_18700969_ChIP-ChIP_MESCs_Mouse0.89687485
175NFE2L2_20460467_ChIP-Seq_MEFs_Mouse0.89528325
176NRF2_20460467_ChIP-Seq_MEFs_Mouse0.89528325
177* ZFX_18555785_ChIP-Seq_MESCs_Mouse0.89430006
178PDX1_19855005_ChIP-ChIP_MIN6_Mouse0.89112779
179AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.88538778
180WT1_19549856_ChIP-ChIP_CCG9911_Human0.88345832
181EZH2_27304074_Chip-Seq_ESCs_Mouse0.88268509
182* TCF4_22108803_ChIP-Seq_LS180_Human0.88232236
183EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse0.88044050
184AR_25329375_ChIP-Seq_VCAP_Human0.86731877
185FOXP2_23625967_ChIP-Seq_PFSK-1_AND_SK-N-MC_Human0.86168865
186Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse0.86003029
187LXR_22292898_ChIP-Seq_THP-1_Human0.85931445
188* GATA2_19941826_ChIP-Seq_K562_Human0.85905474
189MITF_21258399_ChIP-Seq_MELANOMA_Human0.85386369

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005058_abnormal_lysosome_morphology4.50639525
2MP0004859_abnormal_synaptic_plasticity4.04806390
3MP0003195_calcinosis3.80284464
4MP0003172_abnormal_lysosome_physiology3.20388796
5MP0003283_abnormal_digestive_organ3.12408797
6MP0004043_abnormal_pH_regulation3.11498257
7MP0003300_gastrointestinal_ulcer3.04106663
8MP0002877_abnormal_melanocyte_morpholog2.77840788
9MP0000569_abnormal_digit_pigmentation2.59066498
10MP0002909_abnormal_adrenal_gland2.56894723
11MP0010094_abnormal_chromosome_stability2.51096347
12MP0000013_abnormal_adipose_tissue2.50591654
13MP0003183_abnormal_peptide_metabolism2.44164154
14MP0006292_abnormal_olfactory_placode2.41893295
15MP0009780_abnormal_chondrocyte_physiolo2.41593242
16MP0008058_abnormal_DNA_repair2.40901578
17MP0003890_abnormal_embryonic-extraembry2.38112980
18MP0001765_abnormal_ion_homeostasis2.34302284
19MP0002102_abnormal_ear_morphology2.13093138
20MP0001529_abnormal_vocalization2.09863464
21MP0005360_urolithiasis2.09662099
22MP0000778_abnormal_nervous_system2.07408821
23MP0003121_genomic_imprinting1.95166021
24MP0003136_yellow_coat_color1.93462158
25MP0003111_abnormal_nucleus_morphology1.93064184
26MP0003635_abnormal_synaptic_transmissio1.87196709
27MP0003693_abnormal_embryo_hatching1.86406730
28MP0002938_white_spotting1.85443967
29MP0005670_abnormal_white_adipose1.84021713
30MP0001944_abnormal_pancreas_morphology1.83183967
31MP0008932_abnormal_embryonic_tissue1.82900017
32MP0001968_abnormal_touch/_nociception1.82043124
33MP0009643_abnormal_urine_homeostasis1.80346204
34MP0002736_abnormal_nociception_after1.77985095
35MP0001756_abnormal_urination1.75679623
36MP0002138_abnormal_hepatobiliary_system1.73158678
37MP0003937_abnormal_limbs/digits/tail_de1.70110555
38MP0001293_anophthalmia1.67884684
39MP0008961_abnormal_basal_metabolism1.67027731
40MP0008057_abnormal_DNA_replication1.66851210
41MP0005171_absent_coat_pigmentation1.66142308
42MP0002139_abnormal_hepatobiliary_system1.62726068
43MP0004957_abnormal_blastocyst_morpholog1.60582175
44MP0003191_abnormal_cellular_cholesterol1.57679173
45MP0003787_abnormal_imprinting1.57306700
46MP0003119_abnormal_digestive_system1.55156759
47MP0004858_abnormal_nervous_system1.54089962
48MP0004270_analgesia1.53559256
49MP0003077_abnormal_cell_cycle1.52411025
50MP0010386_abnormal_urinary_bladder1.52128997
51MP0005220_abnormal_exocrine_pancreas1.50821157
52MP0010030_abnormal_orbit_morphology1.49691803
53MP0001188_hyperpigmentation1.48975680
54MP0002064_seizures1.48767001
55MP0004133_heterotaxia1.47148562
56MP0003123_paternal_imprinting1.44079190
57MP0000049_abnormal_middle_ear1.42859098
58MP0008789_abnormal_olfactory_epithelium1.42527823
59MP0001986_abnormal_taste_sensitivity1.41564261
60MP0002233_abnormal_nose_morphology1.41525594
61MP0006276_abnormal_autonomic_nervous1.40436797
62MP0002751_abnormal_autonomic_nervous1.38829235
63MP0005499_abnormal_olfactory_system1.34512888
64MP0005394_taste/olfaction_phenotype1.34512888
65MP0002063_abnormal_learning/memory/cond1.33996588
66MP0002693_abnormal_pancreas_physiology1.33114183
67MP0000685_abnormal_immune_system1.31020486
68MP0001299_abnormal_eye_distance/1.30004254
69MP0002396_abnormal_hematopoietic_system1.29846891
70MP0002876_abnormal_thyroid_physiology1.29652711
71MP0006072_abnormal_retinal_apoptosis1.28819318
72MP0009745_abnormal_behavioral_response1.28100191
73MP0003075_altered_response_to1.27521245
74MP0009697_abnormal_copulation1.26865149
75MP0003861_abnormal_nervous_system1.26538078
76MP0002184_abnormal_innervation1.25953278
77MP0000955_abnormal_spinal_cord1.24783867
78MP0003868_abnormal_feces_composition1.24724150
79MP0002572_abnormal_emotion/affect_behav1.23268037
80MP0005646_abnormal_pituitary_gland1.22981232
81MP0000372_irregular_coat_pigmentation1.20986388
82MP0005464_abnormal_platelet_physiology1.20720385
83MP0005636_abnormal_mineral_homeostasis1.20068653
84MP0003879_abnormal_hair_cell1.19050823
85MP0002084_abnormal_developmental_patter1.17980516
86MP0005332_abnormal_amino_acid1.17588912
87MP0002078_abnormal_glucose_homeostasis1.17149697
88MP0002735_abnormal_chemical_nociception1.16980709
89MP0001958_emphysema1.16323255
90MP0002697_abnormal_eye_size1.16095366
91MP0001286_abnormal_eye_development1.15954527
92MP0000631_abnormal_neuroendocrine_gland1.14361219
93MP0001984_abnormal_olfaction1.12706479
94MP0003122_maternal_imprinting1.11939773
95MP0000678_abnormal_parathyroid_gland1.11325730
96MP0005187_abnormal_penis_morphology1.10693867
97MP0003567_abnormal_fetal_cardiomyocyte1.10324236
98MP0005253_abnormal_eye_physiology1.10197124
99MP0000566_synostosis1.09950054
100MP0005365_abnormal_bile_salt1.08878546
101MP0002928_abnormal_bile_duct1.08511889
102MP0002136_abnormal_kidney_physiology1.07290410
103MP0008007_abnormal_cellular_replicative1.06068547
104MP0003755_abnormal_palate_morphology1.05401437
105MP0002234_abnormal_pharynx_morphology1.05355125
106MP0000647_abnormal_sebaceous_gland1.04148247
107MP0002557_abnormal_social/conspecific_i1.01531254
108MP0003880_abnormal_central_pattern1.01460411
109MP0005535_abnormal_body_temperature1.00524729
110MP0002085_abnormal_embryonic_tissue1.00231770
111MP0002152_abnormal_brain_morphology1.00006816
112MP0003718_maternal_effect0.99347606
113MP0005423_abnormal_somatic_nervous0.98596439
114MP0004264_abnormal_extraembryonic_tissu0.98471173
115MP0001177_atelectasis0.98230606
116MP0000537_abnormal_urethra_morphology0.97516909
117MP0003938_abnormal_ear_development0.97179475
118MP0005584_abnormal_enzyme/coenzyme_acti0.96351407
119MP0003942_abnormal_urinary_system0.95356268
120MP0005310_abnormal_salivary_gland0.95235878
121MP0005391_vision/eye_phenotype0.95009876
122MP0000639_abnormal_adrenal_gland0.94828105
123MP0009046_muscle_twitch0.94683807
124MP0004885_abnormal_endolymph0.94456869
125MP0002882_abnormal_neuron_morphology0.94084717
126MP0003385_abnormal_body_wall0.93909416
127MP0006054_spinal_hemorrhage0.92709509
128MP0003935_abnormal_craniofacial_develop0.91918113
129MP0000230_abnormal_systemic_arterial0.91799641
130MP0002752_abnormal_somatic_nervous0.91312525
131MP0003633_abnormal_nervous_system0.90600831
132MP0002822_catalepsy0.89071903
133MP0002272_abnormal_nervous_system0.88746871
134MP0004808_abnormal_hematopoietic_stem0.86824828
135MP0001697_abnormal_embryo_size0.86539292
136MP0001486_abnormal_startle_reflex0.86475773
137MP0010368_abnormal_lymphatic_system0.86012705
138MP0005551_abnormal_eye_electrophysiolog0.85980470
139MP0001730_embryonic_growth_arrest0.85538761
140MP0002090_abnormal_vision0.85455651
141MP0000003_abnormal_adipose_tissue0.84930966
142MP0003941_abnormal_skin_development0.84856771
143MP0004811_abnormal_neuron_physiology0.83723524
144MP0005248_abnormal_Harderian_gland0.83409341
145MP0005408_hypopigmentation0.83199518
146MP0001324_abnormal_eye_pigmentation0.83150267
147MP0006035_abnormal_mitochondrial_morpho0.81679077
148MP0003315_abnormal_perineum_morphology0.81288030
149MP0009672_abnormal_birth_weight0.81039017
150MP0002135_abnormal_kidney_morphology0.80946083
151MP0002166_altered_tumor_susceptibility0.80651009
152MP0003953_abnormal_hormone_level0.80133176
153MP0002638_abnormal_pupillary_reflex0.79451785
154MP0002081_perinatal_lethality0.79393790
155MP0002733_abnormal_thermal_nociception0.78440764
156MP0002896_abnormal_bone_mineralization0.77540473
157MP0002089_abnormal_postnatal_growth/wei0.76321252
158MP0008569_lethality_at_weaning0.75961362
159MP0002067_abnormal_sensory_capabilities0.75396828
160MP0002295_abnormal_pulmonary_circulatio0.73304014
161MP0003959_abnormal_lean_body0.72612723
162MP0001501_abnormal_sleep_pattern0.72480463
163MP0005379_endocrine/exocrine_gland_phen0.72271136
164MP0001270_distended_abdomen0.71152263
165MP0008874_decreased_physiological_sensi0.70336777
166MP0010329_abnormal_lipoprotein_level0.69631007
167MP0008877_abnormal_DNA_methylation0.69435811
168MP0002734_abnormal_mechanical_nocicepti0.69094251
169MP0001502_abnormal_circadian_rhythm0.68755583
170MP0001970_abnormal_pain_threshold0.68589324
171MP0002069_abnormal_eating/drinking_beha0.66920257
172MP0003329_amyloid_beta_deposits0.66769758
173MP0003795_abnormal_bone_structure0.65863107
174MP0000604_amyloidosis0.63648381
175MP0002168_other_aberrant_phenotype0.63048715
176MP0004147_increased_porphyrin_level0.61912119
177MP0000681_abnormal_thyroid_gland0.61208251

Predicted human phenotypes

RankGene SetZ-score
1Dysostosis multiplex (HP:0000943)4.71106635
2Elevated circulating parathyroid hormone (PTH) level (HP:0003165)4.15003232
3Mucopolysacchariduria (HP:0008155)3.86584396
4Urinary glycosaminoglycan excretion (HP:0003541)3.86584396
5Vacuolated lymphocytes (HP:0001922)3.86060314
6Abnormality of the labia minora (HP:0012880)3.80340035
7Abnormality of polysaccharide metabolism (HP:0011012)3.67000665
8Abnormality of glycosaminoglycan metabolism (HP:0004371)3.67000665
9Abnormality of mucopolysaccharide metabolism (HP:0011020)3.67000665
10Cortical dysplasia (HP:0002539)3.56372076
11Papilledema (HP:0001085)3.39516398
12Increased cerebral lipofuscin (HP:0011813)3.15118296
13Increased circulating renin level (HP:0000848)3.05115210
14Symptomatic seizures (HP:0011145)2.96201955
15Hypomagnesemia (HP:0002917)2.93331924
16Chromsome breakage (HP:0040012)2.89222065
17Thin bony cortex (HP:0002753)2.87424194
18Increased neuronal autofluorescent lipopigment (HP:0002074)2.78562190
19Chromosomal breakage induced by crosslinking agents (HP:0003221)2.75034828
20Metabolic alkalosis (HP:0200114)2.73975131
21Abnormality of calcium-phosphate metabolism (HP:0100530)2.70747445
22Polyuria (HP:0000103)2.68894797
23Hyperactive renin-angiotensin system (HP:0000841)2.64955988
24Hypokalemic alkalosis (HP:0001949)2.64340224
25Abnormal drinking behavior (HP:0030082)2.60903815
26Polydipsia (HP:0001959)2.60903815
27Colon cancer (HP:0003003)2.58723279
28Abnormality of magnesium homeostasis (HP:0004921)2.58516754
29Ketoacidosis (HP:0001993)2.55868688
30Gonadotropin excess (HP:0000837)2.55453348
31Abnormal urine output (HP:0012590)2.54371445
32Hypoplasia of the thymus (HP:0000778)2.53875566
33Focal motor seizures (HP:0011153)2.47931279
34High anterior hairline (HP:0009890)2.47423190
35Spondylolisthesis (HP:0003302)2.46741413
36Meckel diverticulum (HP:0002245)2.41770522
37Abnormality of the thoracic spine (HP:0100711)2.41692863
38Aplasia/Hypoplasia of the uvula (HP:0010293)2.35848157
39Spinal canal stenosis (HP:0003416)2.35524752
40Striae distensae (HP:0001065)2.35512441
41Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)2.33339914
42Gout (HP:0001997)2.32415056
43Late onset (HP:0003584)2.32221693
44Abnormality of chloride homeostasis (HP:0011422)2.30275145
45Abnormality of the ileum (HP:0001549)2.30207252
46Abnormal lung lobation (HP:0002101)2.30164477
47Ependymoma (HP:0002888)2.29770939
48Beaking of vertebral bodies (HP:0004568)2.28740763
49Hypoglycemic seizures (HP:0002173)2.27358169
50Generalized aminoaciduria (HP:0002909)2.26390464
51Oligomenorrhea (HP:0000876)2.25122042
52Birth length less than 3rd percentile (HP:0003561)2.25040709
53Glucose intolerance (HP:0000833)2.24631448
54Hypokalemia (HP:0002900)2.22489130
55Hepatoblastoma (HP:0002884)2.18645495
56Hyperinsulinemic hypoglycemia (HP:0000825)2.18110623
57Tetany (HP:0001281)2.17144826
58Abnormality of chromosome stability (HP:0003220)2.16308496
59Abnormality of glycolysis (HP:0004366)2.15879854
60Retinal dysplasia (HP:0007973)2.15653636
61Parkinsonism with favorable response to dopaminergic medication (HP:0002548)2.15242208
62Hyperglycinemia (HP:0002154)2.14945407
63Vertebral compression fractures (HP:0002953)2.14434943
64Alkalosis (HP:0001948)2.14018947
65Truncal obesity (HP:0001956)2.13572631
66Abnormality of glycolipid metabolism (HP:0010969)2.13477990
67Abnormality of liposaccharide metabolism (HP:0010968)2.13477990
68Abnormality of glycosphingolipid metabolism (HP:0004343)2.13477990
69Chronic otitis media (HP:0000389)2.13042848
70Cervical subluxation (HP:0003308)2.12682040
71Abnormality of renin-angiotensin system (HP:0000847)2.12517541
72Abnormality of renal excretion (HP:0011036)2.10103515
73Thoracic kyphosis (HP:0002942)2.09729411
74Ectopic kidney (HP:0000086)2.09205509
75IgM deficiency (HP:0002850)2.07876237
76Flat occiput (HP:0005469)2.07182890
77Abnormality of the lumbar spine (HP:0100712)2.06289795
78Bifid tongue (HP:0010297)2.04319906
79Agitation (HP:0000713)2.03810826
80Drooling (HP:0002307)2.03453436
81Glomerulonephritis (HP:0000099)2.03026374
82Anophthalmia (HP:0000528)2.03022722
83Abnormality of the common coagulation pathway (HP:0010990)2.01681854
84Hypoplastic pelvis (HP:0008839)2.00852612
85Abnormality of binocular vision (HP:0011514)1.99568926
86Diplopia (HP:0000651)1.99568926
87Increased serum pyruvate (HP:0003542)1.98128232
88Protuberant abdomen (HP:0001538)1.96467062
89Glioma (HP:0009733)1.94911697
90Supernumerary spleens (HP:0009799)1.93439276
91Esophageal atresia (HP:0002032)1.93012469
92Abnormality of the astrocytes (HP:0100707)1.92700130
93Astrocytoma (HP:0009592)1.92700130
94Delayed epiphyseal ossification (HP:0002663)1.90499581
95Septo-optic dysplasia (HP:0100842)1.90410617
96Long toe (HP:0010511)1.90282791
97Abnormal eating behavior (HP:0100738)1.85803252
98Cutaneous finger syndactyly (HP:0010554)1.84443869
99Preaxial hand polydactyly (HP:0001177)1.84384668
100Volvulus (HP:0002580)1.84133817
101Lissencephaly (HP:0001339)1.84016049
102Aortic aneurysm (HP:0004942)1.83561088
103Horseshoe kidney (HP:0000085)1.81312845
104Metaphyseal dysplasia (HP:0100255)1.81026223
105Enlarged penis (HP:0000040)1.80306540
106Menstrual irregularities (HP:0000858)1.80018719
107Myokymia (HP:0002411)1.79540600
108Abnormality of the carotid arteries (HP:0005344)1.78222570
109Triphalangeal thumb (HP:0001199)1.76948984
110Vaginal atresia (HP:0000148)1.76704263
111Genital tract atresia (HP:0001827)1.76070157
112Oligodactyly (hands) (HP:0001180)1.75592395
113Abnormality of the intrinsic pathway (HP:0010989)1.74926150
114Patellar aplasia (HP:0006443)1.74510238
115Pancreatic fibrosis (HP:0100732)1.74145673
116Medulloblastoma (HP:0002885)1.73978535
117Focal seizures (HP:0007359)1.73517959
118Bilateral microphthalmos (HP:0007633)1.73348543
119Duodenal stenosis (HP:0100867)1.73321051
120Small intestinal stenosis (HP:0012848)1.73321051
121Aplasia/Hypoplasia of the sternum (HP:0006714)1.72702694
122Gait imbalance (HP:0002141)1.72232654
123Ketosis (HP:0001946)1.71816700
124Epileptic encephalopathy (HP:0200134)1.70523153
125Abnormality of proline metabolism (HP:0010907)1.70054587
126Hydroxyprolinuria (HP:0003080)1.70054587
127Optic nerve hypoplasia (HP:0000609)1.70015115
128Medial flaring of the eyebrow (HP:0010747)1.69764184
129Absent radius (HP:0003974)1.69524678
130Excessive salivation (HP:0003781)1.68616063
131Protrusio acetabuli (HP:0003179)1.68569079
132Hypophosphatemia (HP:0002148)1.68550852
133Aplasia involving forearm bones (HP:0009822)1.68507697
134Absent forearm bone (HP:0003953)1.68507697
135Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.67972922
136Neoplasm of the heart (HP:0100544)1.67103402
137Hand muscle atrophy (HP:0009130)1.66796045
138Increased nuchal translucency (HP:0010880)1.66619901
139Proximal tubulopathy (HP:0000114)1.65644967
140Growth hormone excess (HP:0000845)1.65218956
141Cerebral aneurysm (HP:0004944)1.65213230
142Pancreatic cysts (HP:0001737)1.64838266
143Reduced antithrombin III activity (HP:0001976)1.64467641
144Truncal ataxia (HP:0002078)1.64288090
145Hypoplasia of the odontoid process (HP:0003311)1.64100300
146Hypoglycemic coma (HP:0001325)1.63743235
147Abnormality of the duodenum (HP:0002246)1.63446509
148Decreased circulating renin level (HP:0003351)1.63189001
149Facial cleft (HP:0002006)1.63185537
150Severe short stature (HP:0003510)1.62793379
151Cutaneous syndactyly (HP:0012725)1.62579040
152Visual hallucinations (HP:0002367)1.62565950
153Abnormality of purine metabolism (HP:0004352)1.62490721
154Congenital primary aphakia (HP:0007707)1.61183379
155Disproportionate short-trunk short stature (HP:0003521)1.60923323
156Gastrointestinal atresia (HP:0002589)1.60801142
157Reticulocytopenia (HP:0001896)1.60695194
158Spontaneous hematomas (HP:0007420)1.60637685
159Impaired smooth pursuit (HP:0007772)1.59932483
160Broad-based gait (HP:0002136)1.59758023
161Generalized tonic-clonic seizures (HP:0002069)1.59580409
162Renal hypoplasia (HP:0000089)1.59024487
163Sloping forehead (HP:0000340)1.58389533
164Thrombocytosis (HP:0001894)1.58154346
165Abnormality of potassium homeostasis (HP:0011042)1.57888374
166Rhabdomyosarcoma (HP:0002859)1.57800257
167Systemic lupus erythematosus (HP:0002725)1.57798004
168Dandy-Walker malformation (HP:0001305)1.57690815
169Hypoplastic female external genitalia (HP:0012815)1.57437316
170Sclerocornea (HP:0000647)1.57112220
171Aplasia/Hypoplasia of the patella (HP:0006498)1.56133323
172Acute necrotizing encephalopathy (HP:0006965)1.55979472
173Abnormality of the preputium (HP:0100587)1.55918674
174Abnormality of methionine metabolism (HP:0010901)1.55522829
175Occipital encephalocele (HP:0002085)1.54424582
176Adrenal hypoplasia (HP:0000835)1.53873208
177Impaired vibration sensation in the lower limbs (HP:0002166)1.53828997
178Oligodactyly (HP:0012165)1.53558740
179Nephrogenic diabetes insipidus (HP:0009806)1.52853235
180Limb dystonia (HP:0002451)1.52833790
181Micropenis (HP:0000054)1.52441815
182Abnormality of cochlea (HP:0000375)1.52047993
183Methylmalonic acidemia (HP:0002912)1.51960830
184Molar tooth sign on MRI (HP:0002419)1.51589284
185Abnormality of midbrain morphology (HP:0002418)1.51589284
186Intestinal atresia (HP:0011100)1.51146463
187Neoplasm of the adrenal cortex (HP:0100641)1.50943513
188Hemivertebrae (HP:0002937)1.50927625
189Broad foot (HP:0001769)1.50887504
190Shoulder girdle muscle weakness (HP:0003547)1.50625818
191Pachygyria (HP:0001302)1.49766239
192Abnormal number of incisors (HP:0011064)1.49690068
193Aplasia/Hypoplasia of the brainstem (HP:0007362)1.48213387
194Hypoplasia of the brainstem (HP:0002365)1.48213387
195Morphological abnormality of the inner ear (HP:0011390)1.48176155
196Postnatal microcephaly (HP:0005484)1.47912992
197Abnormal hair whorl (HP:0010721)1.47634656
198Postaxial hand polydactyly (HP:0001162)1.47524624

Predicted kinase interactions (KEA)

RankGene SetZ-score
1SRPK12.94817677
2MAPKAPK32.87559836
3SCYL22.80440959
4NTRK32.76269521
5DAPK12.75982508
6CDC72.74088460
7INSRR2.70942095
8CAMKK22.59456241
9ERN12.57541011
10PRKD32.51878359
11ZAK2.38465223
12TRIB32.34258673
13PASK2.30093040
14MARK12.29737558
15EPHA42.27663720
16TRIM282.25917414
17CASK2.23254012
18CAMKK12.20540326
19MAP3K132.18382112
20TTK2.14565327
21BUB12.10000581
22MKNK12.06848583
23BMPR1B2.00688563
24BCR1.98503850
25PLK31.96553787
26WNK41.95722304
27PBK1.94182478
28MKNK21.93730245
29PLK41.88040982
30MAP3K41.87846268
31WEE11.86021313
32TSSK61.84555266
33PNCK1.77071905
34KIT1.73288384
35KSR21.71009852
36MAP2K71.70465546
37FLT31.65847285
38DYRK21.64074533
39RIPK41.56689020
40DAPK21.52762700
41CSNK1G21.52000830
42HIPK21.45166992
43TAOK31.44769287
44CSNK1G31.42554182
45CSNK1G11.38890355
46NEK91.38756651
47RET1.37968194
48STK161.37581617
49PLK11.37181574
50WNK31.37150403
51MINK11.37033700
52MAP3K91.35316324
53OXSR11.34942836
54CSNK1A1L1.33940302
55FES1.33647917
56EPHA31.33077602
57PKN21.32165455
58BRSK11.29147710
59EIF2AK31.28934582
60NEK11.26751214
61JAK11.26189390
62CDK51.22916002
63SIK21.21641885
64PDGFRA1.17847610
65MAP4K11.17802982
66BRSK21.16556904
67DYRK31.15549170
68TEC1.14676357
69SGK31.13907465
70ATR1.13495218
71NTRK11.13294854
72TAF11.12425376
73MAPK131.11975825
74MAP2K41.09721292
75CHEK21.09674505
76ITK1.09122741
77SGK21.08093722
78MAP3K21.03697860
79PRKCH1.03053265
80NUAK11.02128080
81CDK191.01782160
82MAP4K21.01763807
83BTK0.98419375
84ZAP700.94948601
85SYK0.94025417
86PTK60.93374329
87MAP3K10.92885479
88CAMK1D0.91959792
89ERBB30.90892253
90TNIK0.90283075
91CAMK1G0.89932310
92ATM0.87216076
93BCKDK0.82793998
94CSF1R0.81927133
95JAK20.81510332
96TNK20.80745531
97ACVR1B0.80218432
98FER0.80056168
99VRK10.80051229
100STK240.79881332
101AURKB0.79286814
102NEK20.79241791
103KSR10.78646569
104ERBB40.76714887
105PAK60.73783284
106STK380.70994027
107PDK10.70805408
108SGK2230.69668938
109SGK4940.69668938
110TYK20.68600896
111SIK10.67898805
112VRK20.66595334
113EPHB20.65908016
114PRKD20.65859072
115JAK30.65593183
116LYN0.64285021
117STK390.64064434
118FGFR40.63892053
119LIMK10.63620318
120STK38L0.62123648
121TGFBR20.61632301
122CSNK1E0.61197632
123CHEK10.60688211
124RIPK10.60119068
125CAMK10.58845749
126DYRK1A0.57943987
127FGFR20.57796204
128PTK2B0.57410621
129CCNB10.56688996
130AURKA0.55413026
131CDK150.53192924
132MAP3K70.53158257
133PRKCG0.52960211
134WNK10.52711240
135PRKDC0.52686122
136LATS10.51716523
137CDK10.50945076
138CDK140.50756805
139TGFBR10.50139520
140UHMK10.50064519
141ALK0.49990317
142PLK20.49960151
143CDK180.49290781
144HCK0.48222019
145PINK10.46396293
146CDK20.45456787
147CAMK2A0.45104562
148PDPK10.43562777
149BRD40.41253004
150PDK20.40869845
151PRKCE0.39982671
152CSNK1D0.39322285
153FGFR10.39301931
154RPS6KA40.39299840
155EIF2AK10.38863485
156SGK10.38802086
157STK30.37548341
158CDC42BPA0.37355046
159CSNK1A10.37130569
160MET0.37100988
161PRKACB0.37034884
162RPS6KA20.37025062
163FGFR30.36882782
164NTRK20.36810619
165SRC0.36675180
166CDK11A0.35826780
167PAK30.34986085
168IGF1R0.34757927
169MATK0.34353602
170DYRK1B0.34022296
171FYN0.33596121
172TESK10.33164284

Predicted pathways (KEGG)

RankGene SetZ-score
1Non-homologous end-joining_Homo sapiens_hsa034502.94801564
2Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049642.81309768
3Mismatch repair_Homo sapiens_hsa034302.79264403
4DNA replication_Homo sapiens_hsa030302.70114476
5Maturity onset diabetes of the young_Homo sapiens_hsa049502.54773659
6Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009702.54447769
7Other glycan degradation_Homo sapiens_hsa005112.42909702
8Lysosome_Homo sapiens_hsa041422.31490092
9Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049612.26310226
10Terpenoid backbone biosynthesis_Homo sapiens_hsa009002.21821550
11Insulin secretion_Homo sapiens_hsa049112.21464983
12Fanconi anemia pathway_Homo sapiens_hsa034602.19669587
13Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006042.18729184
14Synaptic vesicle cycle_Homo sapiens_hsa047212.15329618
15Nitrogen metabolism_Homo sapiens_hsa009102.12784696
16Steroid biosynthesis_Homo sapiens_hsa001002.12690675
17Homologous recombination_Homo sapiens_hsa034402.08036458
18Glycosaminoglycan degradation_Homo sapiens_hsa005311.96070995
19RNA polymerase_Homo sapiens_hsa030201.93072233
20Long-term potentiation_Homo sapiens_hsa047201.86611310
21Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.84273796
22RNA transport_Homo sapiens_hsa030131.79093741
23Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.79038821
24Proteasome_Homo sapiens_hsa030501.78164001
25Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.75974356
26Base excision repair_Homo sapiens_hsa034101.75909353
27Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.72199569
28Cell cycle_Homo sapiens_hsa041101.70498381
29N-Glycan biosynthesis_Homo sapiens_hsa005101.69782682
30One carbon pool by folate_Homo sapiens_hsa006701.69186218
31Basal transcription factors_Homo sapiens_hsa030221.68526207
32Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.63994086
33Amphetamine addiction_Homo sapiens_hsa050311.62877118
34GABAergic synapse_Homo sapiens_hsa047271.59751312
35Nucleotide excision repair_Homo sapiens_hsa034201.59232373
36Propanoate metabolism_Homo sapiens_hsa006401.56972287
37Circadian entrainment_Homo sapiens_hsa047131.55719621
38Olfactory transduction_Homo sapiens_hsa047401.54214574
39Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.52943500
40Carbohydrate digestion and absorption_Homo sapiens_hsa049731.50518547
41Morphine addiction_Homo sapiens_hsa050321.45391229
42Spliceosome_Homo sapiens_hsa030401.44715194
43Vibrio cholerae infection_Homo sapiens_hsa051101.44406750
44Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.43135112
45Protein export_Homo sapiens_hsa030601.41641339
46Cocaine addiction_Homo sapiens_hsa050301.41620877
47Cysteine and methionine metabolism_Homo sapiens_hsa002701.41185042
48Dopaminergic synapse_Homo sapiens_hsa047281.39733879
49Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.39305398
50SNARE interactions in vesicular transport_Homo sapiens_hsa041301.38232517
51Oxidative phosphorylation_Homo sapiens_hsa001901.35153954
52Parkinsons disease_Homo sapiens_hsa050121.32929599
53RNA degradation_Homo sapiens_hsa030181.30672549
54Type II diabetes mellitus_Homo sapiens_hsa049301.29288486
55Glutamatergic synapse_Homo sapiens_hsa047241.28652560
56Fructose and mannose metabolism_Homo sapiens_hsa000511.28263037
572-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.27951212
58Thyroid hormone synthesis_Homo sapiens_hsa049181.27172504
59Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.24023110
60Pyruvate metabolism_Homo sapiens_hsa006201.23307561
61Fatty acid elongation_Homo sapiens_hsa000621.22912659
62Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.22596961
63Aldosterone synthesis and secretion_Homo sapiens_hsa049251.22290896
64Vitamin B6 metabolism_Homo sapiens_hsa007501.21836790
65Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.21767363
66Pyrimidine metabolism_Homo sapiens_hsa002401.21124661
67Renin secretion_Homo sapiens_hsa049241.19460280
68mRNA surveillance pathway_Homo sapiens_hsa030151.11693799
69Biosynthesis of amino acids_Homo sapiens_hsa012301.09561049
70Nicotine addiction_Homo sapiens_hsa050331.07071627
71Huntingtons disease_Homo sapiens_hsa050161.06423872
72Gastric acid secretion_Homo sapiens_hsa049711.04873299
73ABC transporters_Homo sapiens_hsa020101.02927427
74Collecting duct acid secretion_Homo sapiens_hsa049661.02619458
75Basal cell carcinoma_Homo sapiens_hsa052171.01744143
76Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.01650633
77Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.01035025
78Thyroid cancer_Homo sapiens_hsa052161.00516598
79Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.99636252
80Hippo signaling pathway_Homo sapiens_hsa043900.99011625
81Hedgehog signaling pathway_Homo sapiens_hsa043400.97840187
82Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.94310042
83Glioma_Homo sapiens_hsa052140.93288041
84Ribosome_Homo sapiens_hsa030100.92656977
85Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.91583005
86Folate biosynthesis_Homo sapiens_hsa007900.91052589
87Purine metabolism_Homo sapiens_hsa002300.90851538
88Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.89772191
89Cholinergic synapse_Homo sapiens_hsa047250.89268866
90cAMP signaling pathway_Homo sapiens_hsa040240.88374017
91Salivary secretion_Homo sapiens_hsa049700.88359549
92Phototransduction_Homo sapiens_hsa047440.87203236
93Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.84416861
94Bile secretion_Homo sapiens_hsa049760.83219270
95Taste transduction_Homo sapiens_hsa047420.82982470
96Carbon metabolism_Homo sapiens_hsa012000.81098593
97Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.80183816
98Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.79900196
99Ovarian steroidogenesis_Homo sapiens_hsa049130.79584564
100Neurotrophin signaling pathway_Homo sapiens_hsa047220.79473304
101Platelet activation_Homo sapiens_hsa046110.78206749
102Oocyte meiosis_Homo sapiens_hsa041140.76314719
103Wnt signaling pathway_Homo sapiens_hsa043100.75688706
104Alzheimers disease_Homo sapiens_hsa050100.74754499
105Long-term depression_Homo sapiens_hsa047300.73873055
106Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.73643244
107Lysine degradation_Homo sapiens_hsa003100.73593062
108Selenocompound metabolism_Homo sapiens_hsa004500.72830373
109Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.70707927
110Gap junction_Homo sapiens_hsa045400.70519988
111Pentose and glucuronate interconversions_Homo sapiens_hsa000400.69966349
112Axon guidance_Homo sapiens_hsa043600.69760486
113Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.69704400
114Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.69661747
115Phospholipase D signaling pathway_Homo sapiens_hsa040720.69348902
116Sulfur metabolism_Homo sapiens_hsa009200.67797032
117Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.66654062
118Non-small cell lung cancer_Homo sapiens_hsa052230.65628457
119cGMP-PKG signaling pathway_Homo sapiens_hsa040220.64318931
120Glucagon signaling pathway_Homo sapiens_hsa049220.64292711
121Fatty acid metabolism_Homo sapiens_hsa012120.62386164
122Cardiac muscle contraction_Homo sapiens_hsa042600.62354127
123Choline metabolism in cancer_Homo sapiens_hsa052310.62302356
124Oxytocin signaling pathway_Homo sapiens_hsa049210.61277577
125Phosphatidylinositol signaling system_Homo sapiens_hsa040700.60418522
126p53 signaling pathway_Homo sapiens_hsa041150.59602572
127Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.59592721
128Butanoate metabolism_Homo sapiens_hsa006500.59251154
129Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.59011041
130Thyroid hormone signaling pathway_Homo sapiens_hsa049190.58605822
131Metabolic pathways_Homo sapiens_hsa011000.56610934
132Sulfur relay system_Homo sapiens_hsa041220.56475404
133GnRH signaling pathway_Homo sapiens_hsa049120.56197426
134Serotonergic synapse_Homo sapiens_hsa047260.54622908
135Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.54569240
136Endocytosis_Homo sapiens_hsa041440.54223563
137Insulin signaling pathway_Homo sapiens_hsa049100.54115149
138Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.53173058
139Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.52990335
140Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.52765495
141TGF-beta signaling pathway_Homo sapiens_hsa043500.52149657
142Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.50522998
143Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.50155276
144Pancreatic cancer_Homo sapiens_hsa052120.47565512
145Protein digestion and absorption_Homo sapiens_hsa049740.47188145
146Galactose metabolism_Homo sapiens_hsa000520.46945963
147Chemokine signaling pathway_Homo sapiens_hsa040620.46464925
148Vascular smooth muscle contraction_Homo sapiens_hsa042700.46314823
149Prion diseases_Homo sapiens_hsa050200.45591490
150Primary bile acid biosynthesis_Homo sapiens_hsa001200.45427223
151Regulation of autophagy_Homo sapiens_hsa041400.44521784
152Insulin resistance_Homo sapiens_hsa049310.44365549
153Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.44227749
154Circadian rhythm_Homo sapiens_hsa047100.43881311
155Melanogenesis_Homo sapiens_hsa049160.42179458
156Prolactin signaling pathway_Homo sapiens_hsa049170.41800764
157Chronic myeloid leukemia_Homo sapiens_hsa052200.40215870
158beta-Alanine metabolism_Homo sapiens_hsa004100.39598873
159Central carbon metabolism in cancer_Homo sapiens_hsa052300.39419595
160Arginine and proline metabolism_Homo sapiens_hsa003300.38933342
161Estrogen signaling pathway_Homo sapiens_hsa049150.38495023
162mTOR signaling pathway_Homo sapiens_hsa041500.37998937
163Osteoclast differentiation_Homo sapiens_hsa043800.37268713
164Sphingolipid metabolism_Homo sapiens_hsa006000.37136361
165Calcium signaling pathway_Homo sapiens_hsa040200.36957745
166Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.33540693
167Peroxisome_Homo sapiens_hsa041460.30503554
168Alcoholism_Homo sapiens_hsa050340.29751676
169Caffeine metabolism_Homo sapiens_hsa002320.29743889

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