SLC35C1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a GDP-fucose transporter that is found in the Golgi apparatus. Mutations in this gene result in congenital disorder of glycosylation type IIc. Multiple transcript variants encoding different isoforms have been found for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)6.31163072
2antigen processing and presentation of endogenous peptide antigen (GO:0002483)6.31163072
3antigen processing and presentation of endogenous antigen (GO:0019883)5.46578520
4positive regulation of gamma-delta T cell activation (GO:0046645)4.51622457
5Arp2/3 complex-mediated actin nucleation (GO:0034314)4.50462684
6protein retention in ER lumen (GO:0006621)4.32107115
7urea metabolic process (GO:0019627)4.18429597
8urea cycle (GO:0000050)4.12293973
9regulation of gamma-delta T cell differentiation (GO:0045586)3.97809964
10ribosomal small subunit assembly (GO:0000028)3.95141098
11antigen processing and presentation via MHC class Ib (GO:0002475)3.91407206
12nitrogen cycle metabolic process (GO:0071941)3.86836140
13positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)3.79801975
14regulation of vascular endothelial growth factor signaling pathway (GO:1900746)3.78126662
15COPI coating of Golgi vesicle (GO:0048205)3.66820408
16Golgi transport vesicle coating (GO:0048200)3.66820408
17regulation of gamma-delta T cell activation (GO:0046643)3.56964570
18positive regulation of B cell differentiation (GO:0045579)3.53967581
19negative regulation of fibrinolysis (GO:0051918)3.53838417
20regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)3.53683488
21actin nucleation (GO:0045010)3.51209298
22complement activation, alternative pathway (GO:0006957)3.49470748
23negative regulation of phagocytosis (GO:0050765)3.45346696
24pentose-phosphate shunt (GO:0006098)3.45183960
25hemidesmosome assembly (GO:0031581)3.44888439
26antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G3.43973843
27peptidyl-glutamic acid carboxylation (GO:0017187)3.41347727
28protein carboxylation (GO:0018214)3.41347727
29protein localization to endosome (GO:0036010)3.39981028
30desmosome organization (GO:0002934)3.29531201
31UDP-N-acetylglucosamine metabolic process (GO:0006047)3.29343449
32defense response to fungus (GO:0050832)3.25471406
33viral transcription (GO:0019083)3.24849974
34positive regulation of triglyceride lipase activity (GO:0061365)3.21720362
35positive regulation of lipoprotein lipase activity (GO:0051006)3.21720362
36cellular glucuronidation (GO:0052695)3.18391302
37hepatocyte apoptotic process (GO:0097284)3.18129470
38negative regulation of erythrocyte differentiation (GO:0045647)3.16143656
39regulation of fibrinolysis (GO:0051917)3.14992682
40GDP-mannose metabolic process (GO:0019673)3.12996249
41SRP-dependent cotranslational protein targeting to membrane (GO:0006614)3.12336778
42regulation of protein activation cascade (GO:2000257)3.11378886
43translational termination (GO:0006415)3.09424272
44NADH metabolic process (GO:0006734)3.09153150
45epoxygenase P450 pathway (GO:0019373)3.06645412
46regulation of plasminogen activation (GO:0010755)3.05888719
47protein targeting to ER (GO:0045047)3.02588571
48fibrinolysis (GO:0042730)3.02559967
49regulation of B cell differentiation (GO:0045577)3.01671198
50leukocyte aggregation (GO:0070486)3.01544767
51cotranslational protein targeting to membrane (GO:0006613)3.00733251
52regulation of interleukin-12 biosynthetic process (GO:0045075)3.00649510
53NADPH regeneration (GO:0006740)2.99518845
54regulation of B cell receptor signaling pathway (GO:0050855)2.99215882
55regulation of antigen processing and presentation of peptide antigen (GO:0002583)2.98924035
56glucuronate metabolic process (GO:0019585)2.98809182
57uronic acid metabolic process (GO:0006063)2.98809182
58positive regulation of Cdc42 GTPase activity (GO:0043089)2.98341039
59L-phenylalanine metabolic process (GO:0006558)2.97411990
60erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)2.97411990
61retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)2.96944218
62hormone catabolic process (GO:0042447)2.96048092
63DNA deamination (GO:0045006)2.96046266
64basement membrane organization (GO:0071711)2.95974464
65regulation of complement activation (GO:0030449)2.95387010
66skin morphogenesis (GO:0043589)2.94115410
67immunoglobulin mediated immune response (GO:0016064)2.93513627
68negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)2.92443719
69fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)2.90515284
70response to fungus (GO:0009620)2.88322897
71establishment of protein localization to endoplasmic reticulum (GO:0072599)2.87799018
72protein localization to endoplasmic reticulum (GO:0070972)2.85985716
73regulation of cholesterol homeostasis (GO:2000188)2.84689999
74positive regulation of pseudopodium assembly (GO:0031274)2.82186511
75proline biosynthetic process (GO:0006561)2.82115351
76virion attachment to host cell (GO:0019062)2.81837459
77adhesion of symbiont to host cell (GO:0044650)2.81837459
78adhesion of symbiont to host (GO:0044406)2.81117116
79translational elongation (GO:0006414)2.80738672
80positive regulation of lamellipodium assembly (GO:0010592)2.80000714
81regulation of extracellular matrix disassembly (GO:0010715)2.78192234
82positive regulation of extracellular matrix organization (GO:1903055)2.77331165
83acute-phase response (GO:0006953)2.76155503
84cell-substrate junction assembly (GO:0007044)2.76095062
85complement activation, classical pathway (GO:0006958)2.75400308
86ethanol oxidation (GO:0006069)2.73066303
87regulation of systemic arterial blood pressure by renin-angiotensin (GO:0003081)2.72276024
88B cell receptor signaling pathway (GO:0050853)2.71385079
89mannose metabolic process (GO:0006013)2.70923595
90proline metabolic process (GO:0006560)2.70068030
91primary alcohol catabolic process (GO:0034310)2.69829395
92maintenance of gastrointestinal epithelium (GO:0030277)2.69675569
93positive regulation of lipid catabolic process (GO:0050996)2.69237242
94cell adhesion mediated by integrin (GO:0033627)2.68144630
95regulation of respiratory burst (GO:0060263)2.66590825
96glucose 6-phosphate metabolic process (GO:0051156)2.64215385
97megakaryocyte development (GO:0035855)2.63531820
98positive regulation of type I interferon-mediated signaling pathway (GO:0060340)2.63291771
99doxorubicin metabolic process (GO:0044598)2.62632488
100daunorubicin metabolic process (GO:0044597)2.62632488
101polyketide metabolic process (GO:0030638)2.62632488
102positive thymic T cell selection (GO:0045059)2.62501016
103regulation of early endosome to late endosome transport (GO:2000641)2.62100429
104positive regulation of membrane protein ectodomain proteolysis (GO:0051044)2.61684532
105complement activation (GO:0006956)2.61289856
106amyloid precursor protein catabolic process (GO:0042987)2.60992995
107regulation of interferon-beta biosynthetic process (GO:0045357)2.60716435
108negative thymic T cell selection (GO:0045060)2.58527366
109negative T cell selection (GO:0043383)2.57830622
110regulation of triglyceride catabolic process (GO:0010896)2.57682259
111negative regulation of lipopolysaccharide-mediated signaling pathway (GO:0031665)2.56993178
112ethanol metabolic process (GO:0006067)2.56625413
113mature B cell differentiation involved in immune response (GO:0002313)2.56104733
114response to interferon-beta (GO:0035456)2.55802958
115stress fiber assembly (GO:0043149)2.54688532
116NIK/NF-kappaB signaling (GO:0038061)2.53617212
117mast cell activation (GO:0045576)2.53437202
118epithelial cell-cell adhesion (GO:0090136)2.53084290
119T cell apoptotic process (GO:0070231)2.52575099
120glutamine family amino acid biosynthetic process (GO:0009084)2.52554152
121regulation of antigen receptor-mediated signaling pathway (GO:0050854)2.52266046
122negative regulation of leukocyte mediated cytotoxicity (GO:0001911)2.52020458
123negative regulation of cell killing (GO:0031342)2.52020458
124B cell mediated immunity (GO:0019724)2.51812638
125nucleotide-sugar biosynthetic process (GO:0009226)2.51642964
126regulation of type I interferon-mediated signaling pathway (GO:0060338)2.51486665
127angiotensin maturation (GO:0002003)2.50131144
128viral life cycle (GO:0019058)2.49162733
129pinocytosis (GO:0006907)2.48561805
130very-low-density lipoprotein particle assembly (GO:0034379)2.48319091
131negative regulation of hemostasis (GO:1900047)2.47919337
132negative regulation of blood coagulation (GO:0030195)2.47919337
133regulation of metalloenzyme activity (GO:0048552)2.47664002
134T cell homeostasis (GO:0043029)2.47207208
135definitive hemopoiesis (GO:0060216)2.46604233
136regulation of T cell receptor signaling pathway (GO:0050856)2.46544526
137response to laminar fluid shear stress (GO:0034616)2.46237949
138COPII vesicle coating (GO:0048208)2.46043225
139signal peptide processing (GO:0006465)2.45774866
140purine nucleotide salvage (GO:0032261)2.45521250
141response to type I interferon (GO:0034340)2.45474453
142protein activation cascade (GO:0072376)2.45396474
143response to protozoan (GO:0001562)2.44922274
144positive regulation of lamellipodium organization (GO:1902745)2.44028724
145mucosal-associated lymphoid tissue development (GO:0048537)2.43615490
146Peyers patch development (GO:0048541)2.43615490
147endodermal cell differentiation (GO:0035987)2.43586180
148folic acid-containing compound biosynthetic process (GO:0009396)2.43544529
149regulation of erythrocyte differentiation (GO:0045646)2.43203301
150cellular response to type I interferon (GO:0071357)2.40944239
151type I interferon signaling pathway (GO:0060337)2.40944239
152myeloid dendritic cell activation (GO:0001773)2.40709488
153hypotonic response (GO:0006971)2.40647589
154regulation of pseudopodium assembly (GO:0031272)2.39975275
155regulation of necroptotic process (GO:0060544)2.39935817
156regulation of apoptotic process involved in morphogenesis (GO:1902337)2.39556812
157fat-soluble vitamin biosynthetic process (GO:0042362)2.39232318
158negative regulation of coagulation (GO:0050819)2.39189836
159maintenance of protein localization in endoplasmic reticulum (GO:0035437)2.38867628
160hyaluronan catabolic process (GO:0030214)2.38556147
161apoptotic cell clearance (GO:0043277)2.38468372
162killing of cells in other organism involved in symbiotic interaction (GO:0051883)2.37988021
163disruption of cells of other organism involved in symbiotic interaction (GO:0051818)2.37988021
164respiratory burst (GO:0045730)2.37877615
165production of molecular mediator involved in inflammatory response (GO:0002532)2.37610333
166membrane protein ectodomain proteolysis (GO:0006509)2.36508414
167lymph node development (GO:0048535)2.36315587
168nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)2.36235045
169interferon-gamma production (GO:0032609)2.35756180
170negative regulation of fatty acid transport (GO:2000192)2.35634479
171drug metabolic process (GO:0017144)2.35625028
172erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)2.35548556
173L-phenylalanine catabolic process (GO:0006559)2.35548556
174alpha-linolenic acid metabolic process (GO:0036109)2.34709345
175focal adhesion assembly (GO:0048041)2.34461586
176cell-substrate adherens junction assembly (GO:0007045)2.34461586
177activation of signaling protein activity involved in unfolded protein response (GO:0006987)2.34237205
178regulation of extracellular matrix organization (GO:1903053)2.34109137
179fucose catabolic process (GO:0019317)2.33563519
180L-fucose metabolic process (GO:0042354)2.33563519
181L-fucose catabolic process (GO:0042355)2.33563519
182cellular response to zinc ion (GO:0071294)2.33269535
183cellular protein complex disassembly (GO:0043624)2.31832049
184cellular response to interleukin-4 (GO:0071353)2.31663699
185chaperone mediated protein folding requiring cofactor (GO:0051085)2.30487610
186hexose catabolic process (GO:0019320)2.30079403
187leukotriene biosynthetic process (GO:0019370)2.29127673
188lymphocyte apoptotic process (GO:0070227)2.28546752
189mature B cell differentiation (GO:0002335)2.28529629
190barbed-end actin filament capping (GO:0051016)2.28152807
191purine-containing compound salvage (GO:0043101)2.27834152
192leukocyte cell-cell adhesion (GO:0007159)2.27681843
193regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)2.27253363
194intestinal absorption (GO:0050892)2.27074242

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human3.97909270
2RARG_19884340_ChIP-ChIP_MEFs_Mouse3.23417817
3IRF8_22096565_ChIP-ChIP_GC-B_Human3.13166144
4MYC_22102868_ChIP-Seq_BL_Human2.96383208
5EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.95204926
6MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.86227405
7TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.85168734
8VDR_21846776_ChIP-Seq_THP-1_Human2.79856870
9THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse2.54114174
10RUNX1_20887958_ChIP-Seq_HPC-7_Mouse2.48116352
11SCL_19346495_ChIP-Seq_HPC-7_Human2.47834594
12* MYB_21317192_ChIP-Seq_ERMYB_Mouse2.45419137
13EGR1_19374776_ChIP-ChIP_THP-1_Human2.44980437
14SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse2.41547191
15STAT6_20620947_ChIP-Seq_CD4_POS_T_Human2.40339157
16ESR2_21235772_ChIP-Seq_MCF-7_Human2.35204800
17RACK7_27058665_Chip-Seq_MCF-7_Human2.33925796
18IRF8_22096565_ChIP-ChIP_GC-B_Mouse2.29068485
19ZNF263_19887448_ChIP-Seq_K562_Human2.18736040
20SPI1_22096565_ChIP-ChIP_GC-B_Mouse2.13976829
21TRIM28_21343339_ChIP-Seq_HEK293_Human2.13417200
22IRF8_21731497_ChIP-ChIP_J774_Mouse2.10955583
23TAL1_20887958_ChIP-Seq_HPC-7_Mouse2.06420654
24NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.98477817
25FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.98156264
26ELF1_17652178_ChIP-ChIP_JURKAT_Human1.97973534
27* MAF_26560356_Chip-Seq_TH1_Human1.97716918
28SPI1_23547873_ChIP-Seq_NB4_Human1.96001758
29* NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.95752425
30VDR_24763502_ChIP-Seq_THP-1_Human1.95514573
31MYB_26560356_Chip-Seq_TH2_Human1.93676914
32ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.91088692
33UTX_26944678_Chip-Seq_JUKART_Human1.89742139
34BRD4_27068464_Chip-Seq_AML-cells_Mouse1.89673538
35ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.88263727
36RUNX1_22412390_ChIP-Seq_EML_Mouse1.87257445
37CLOCK_20551151_ChIP-Seq_293T_Human1.86538385
38TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.85389890
39TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.82392481
40STAT4_19710469_ChIP-ChIP_TH1__Mouse1.80789474
41PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.78404544
42IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.77586778
43SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.75260714
44MYB_26560356_Chip-Seq_TH1_Human1.74498064
45* KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.72466024
46TCF7_22412390_ChIP-Seq_EML_Mouse1.71094593
47SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.69882923
48MYC_18555785_ChIP-Seq_MESCs_Mouse1.69048374
49TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.67906595
50NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.67247655
51* E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.66708328
52TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.65176177
53RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.63837948
54FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.63722499
55GATA1_22383799_ChIP-Seq_G1ME_Mouse1.63264084
56IRF8_27001747_Chip-Seq_BMDM_Mouse1.63153752
57FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.57188724
58PPARA_22158963_ChIP-Seq_LIVER_Mouse1.55831678
59ESR1_21235772_ChIP-Seq_MCF-7_Human1.55404238
60GATA1_22025678_ChIP-Seq_K562_Human1.54599619
61* UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.53967157
62STAT6_21828071_ChIP-Seq_BEAS2B_Human1.53011830
63TET1_21451524_ChIP-Seq_MESCs_Mouse1.52288880
64ERG_20887958_ChIP-Seq_HPC-7_Mouse1.50250753
65LXR_22158963_ChIP-Seq_LIVER_Mouse1.50009486
66FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.46857513
67MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.43954723
68SOX2_27498859_Chip-Seq_STOMACH_Mouse1.43536634
69ATF3_27146783_Chip-Seq_COLON_Human1.43402572
70PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.43197887
71* P300_27058665_Chip-Seq_ZR-75-30cells_Human1.41894925
72* ELK3_25401928_ChIP-Seq_HUVEC_Human1.41426466
73GATA2_22383799_ChIP-Seq_G1ME_Mouse1.41309033
74STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.38565779
75SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.37968757
76* LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.37251000
77KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.36462029
78* KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.36369603
79CIITA_25753668_ChIP-Seq_RAJI_Human1.36084245
80NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.35202133
81P63_26484246_Chip-Seq_KERATINOCYTES_Human1.34188724
82NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.32643584
83RXR_22158963_ChIP-Seq_LIVER_Mouse1.32362909
84KDM2B_26808549_Chip-Seq_K562_Human1.31952549
85RUNX_20019798_ChIP-Seq_JUKART_Human1.31700886
86TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.31531767
87* SPI1_23127762_ChIP-Seq_K562_Human1.31098234
88CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.30879648
89SA1_27219007_Chip-Seq_ERYTHROID_Human1.30608658
90GFI1B_20887958_ChIP-Seq_HPC-7_Mouse1.29729213
91* MAF_26560356_Chip-Seq_TH2_Human1.29229415
92BP1_19119308_ChIP-ChIP_Hs578T_Human1.29111139
93* ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.28855910
94* TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.28461069
95HOXB4_20404135_ChIP-ChIP_EML_Mouse1.28124311
96SRY_22984422_ChIP-ChIP_TESTIS_Rat1.26981032
97HIF1A_21447827_ChIP-Seq_MCF-7_Human1.26847711
98SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.25866961
99CTCF_27219007_Chip-Seq_ERYTHROID_Human1.25858490
100MYC_18358816_ChIP-ChIP_MESCs_Mouse1.25413042
101XRN2_22483619_ChIP-Seq_HELA_Human1.25106147
102* SMC4_20622854_ChIP-Seq_HELA_Human1.24723453
103SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.24603881
104* LXR_22292898_ChIP-Seq_THP-1_Human1.24519278
105* SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.24175743
106FOXM1_23109430_ChIP-Seq_U2OS_Human1.24031161
107NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.24013761
108ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.23375681
109LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.22466825
110RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.22026089
111CDX2_20551321_ChIP-Seq_CACO-2_Human1.21677821
112* KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.20931753
113SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.20793951
114TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.19877802
115* P68_20966046_ChIP-Seq_HELA_Human1.19424894
116* GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.18990287
117MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.17992896
118FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.17672342
119CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.17315751
120DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.17228681
121ERG_21242973_ChIP-ChIP_JURKAT_Human1.16669914
122ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.14953474
123TP53_22127205_ChIP-Seq_IMR90_Human1.14746636
124STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.13940724
125SOX2_20726797_ChIP-Seq_SW620_Human1.12608322
126EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.12510728
127SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.11875942
128SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.11875942
129* RUNX1_27514584_Chip-Seq_MCF-7_Human1.11840240
130STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.10534304
131* GATA1_19941827_ChIP-Seq_MEL_Mouse1.10337062
132ZFP281_18757296_ChIP-ChIP_E14_Mouse1.09312788
133* KDM2B_26808549_Chip-Seq_DND41_Human1.08574715
134NOTCH1_21737748_ChIP-Seq_TLL_Human1.08435311
135CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.07777867
136EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.07425418
137* CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.07129982
138CREB1_26743006_Chip-Seq_LNCaP_Human1.07008477
139FOXP3_21729870_ChIP-Seq_TREG_Human1.06896765
140DNAJC2_21179169_ChIP-ChIP_NT2_Human1.06893266
141UBF1/2_26484160_Chip-Seq_HMECs_Human1.05758876
142WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.05069477
143GATA3_27048872_Chip-Seq_THYMUS_Human1.04945395
144VDR_23849224_ChIP-Seq_CD4+_Human1.04782043
145CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.04709513
146BCOR_27268052_Chip-Seq_Bcells_Human1.04240340
147GABP_17652178_ChIP-ChIP_JURKAT_Human1.03939433
148CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.03556053
149* GATA6_25053715_ChIP-Seq_YYC3_Human1.02947842
150SMC1_22415368_ChIP-Seq_MEFs_Mouse1.02633014
151EST1_17652178_ChIP-ChIP_JURKAT_Human1.01891604
152MYC_19079543_ChIP-ChIP_MESCs_Mouse1.01171096
153HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.00116681
154GABP_19822575_ChIP-Seq_HepG2_Human0.99468070
155KLF4_18555785_ChIP-Seq_MESCs_Mouse0.99309949
156PU.1_20513432_ChIP-Seq_Bcells_Mouse0.99304255
157ETS1_20019798_ChIP-Seq_JURKAT_Human0.99112116
158ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.98869900
159* SREBP2_21459322_ChIP-Seq_LIVER_Mouse0.98852074
160NCOR1_26117541_ChIP-Seq_K562_Human0.98092796
161TP63_22573176_ChIP-Seq_HFKS_Human0.98081538
162PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse0.96388670
163PU_27001747_Chip-Seq_BMDM_Mouse0.96224152
164PPAR_26484153_Chip-Seq_NCI-H1993_Human0.95193893
165* KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human0.95037343
166* BCL6_27268052_Chip-Seq_Bcells_Human0.94330279
167* KDM2B_26808549_Chip-Seq_SUP-B15_Human0.94124791
168JARID1B-DAIN_22020125_ChIP-Seq_ESCs_Mouse0.94018711
169ELF1_20517297_ChIP-Seq_JURKAT_Human0.93941300
170TP63_17297297_ChIP-ChIP_HaCaT_Human0.93808343
171* MYC_19030024_ChIP-ChIP_MESCs_Mouse0.93654090

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008438_abnormal_cutaneous_collagen3.50459199
2MP0001835_abnormal_antigen_presentation2.84075693
3MP0003300_gastrointestinal_ulcer2.66938510
4MP0003436_decreased_susceptibility_to2.64006672
5MP0003866_abnormal_defecation2.54535550
6MP0002396_abnormal_hematopoietic_system2.53831703
7MP0001873_stomach_inflammation2.47404911
8MP0000685_abnormal_immune_system2.47074853
9MP0005451_abnormal_body_composition2.41079649
10MP0010155_abnormal_intestine_physiology2.35088151
11MP0009785_altered_susceptibility_to2.34755390
12MP0003763_abnormal_thymus_physiology2.31897926
13MP0005464_abnormal_platelet_physiology2.29479050
14MP0000490_abnormal_crypts_of2.25315919
15MP0001800_abnormal_humoral_immune2.22915357
16MP0005025_abnormal_response_to2.20853966
17MP0005671_abnormal_response_to2.15907447
18MP0006054_spinal_hemorrhage2.15628474
19MP0003303_peritoneal_inflammation2.09052757
20MP0002452_abnormal_antigen_presenting2.00682831
21* MP0002420_abnormal_adaptive_immunity1.98977715
22MP0001790_abnormal_immune_system1.98608309
23MP0005387_immune_system_phenotype1.98608309
24MP0003693_abnormal_embryo_hatching1.98585643
25* MP0001819_abnormal_immune_cell1.96878127
26* MP0002398_abnormal_bone_marrow1.96344230
27MP0005000_abnormal_immune_tolerance1.96145095
28MP0000465_gastrointestinal_hemorrhage1.95315708
29MP0002166_altered_tumor_susceptibility1.95158924
30MP0004272_abnormal_basement_membrane1.94384431
31MP0002419_abnormal_innate_immunity1.93999589
32MP0002723_abnormal_immune_serum1.92514702
33MP0010352_gastrointestinal_tract_polyps1.91561440
34MP0009333_abnormal_splenocyte_physiolog1.91205929
35MP0004264_abnormal_extraembryonic_tissu1.88078062
36MP0004858_abnormal_nervous_system1.87283574
37MP0009840_abnormal_foam_cell1.86943201
38MP0008260_abnormal_autophagy1.86157106
39MP0001849_ear_inflammation1.85977800
40MP0005360_urolithiasis1.85568110
41MP0005257_abnormal_intraocular_pressure1.84625508
42MP0002796_impaired_skin_barrier1.80732688
43MP0001666_abnormal_nutrient_absorption1.77104795
44MP0003279_aneurysm1.73805380
45* MP0000716_abnormal_immune_system1.72016520
46MP0001845_abnormal_inflammatory_respons1.68623534
47MP0000689_abnormal_spleen_morphology1.68364857
48MP0002405_respiratory_system_inflammati1.68157895
49MP0004808_abnormal_hematopoietic_stem1.67818432
50* MP0002722_abnormal_immune_system1.67548840
51MP0002148_abnormal_hypersensitivity_rea1.66872600
52MP0001545_abnormal_hematopoietic_system1.66432038
53MP0005397_hematopoietic_system_phenotyp1.66432038
54MP0002138_abnormal_hepatobiliary_system1.65923681
55MP0001958_emphysema1.63783735
56MP0005409_darkened_coat_color1.63027397
57MP0003191_abnormal_cellular_cholesterol1.62179941
58MP0003183_abnormal_peptide_metabolism1.61915392
59MP0004947_skin_inflammation1.60472339
60* MP0002429_abnormal_blood_cell1.58364636
61MP0005365_abnormal_bile_salt1.58312321
62MP0010234_abnormal_vibrissa_follicle1.58179229
63MP0003724_increased_susceptibility_to1.53369464
64MP0003656_abnormal_erythrocyte_physiolo1.50426842
65MP0002006_tumorigenesis1.48028806
66MP0003172_abnormal_lysosome_physiology1.47565629
67MP0003091_abnormal_cell_migration1.45984328
68MP0001663_abnormal_digestive_system1.44796752
69MP0001853_heart_inflammation1.38566295
70MP0009384_cardiac_valve_regurgitation1.38514739
71MP0008469_abnormal_protein_level1.36409604
72MP0003453_abnormal_keratinocyte_physiol1.35385092
73MP0005058_abnormal_lysosome_morphology1.32923976
74MP0002060_abnormal_skin_morphology1.32124993
75MP0005275_abnormal_skin_tensile1.32058022
76MP0005501_abnormal_skin_physiology1.30591581
77MP0001533_abnormal_skeleton_physiology1.27765007
78MP0006082_CNS_inflammation1.27550467
79MP0005174_abnormal_tail_pigmentation1.25672645
80MP0000678_abnormal_parathyroid_gland1.25170144
81MP0002877_abnormal_melanocyte_morpholog1.24306116
82MP0000858_altered_metastatic_potential1.23892231
83MP0000703_abnormal_thymus_morphology1.23448786
84MP0005670_abnormal_white_adipose1.21560374
85MP0005085_abnormal_gallbladder_physiolo1.21256226
86MP0000477_abnormal_intestine_morphology1.19793695
87MP0005310_abnormal_salivary_gland1.19147063
88MP0000604_amyloidosis1.17685136
89MP0003329_amyloid_beta_deposits1.16238996
90MP0000609_abnormal_liver_physiology1.15943716
91MP0002139_abnormal_hepatobiliary_system1.15942425
92MP0000467_abnormal_esophagus_morphology1.14965546
93MP0005083_abnormal_biliary_tract1.10414021
94MP0001542_abnormal_bone_strength1.07539327
95MP0008875_abnormal_xenobiotic_pharmacok1.05875923
96MP0002019_abnormal_tumor_incidence1.05763209
97MP0003252_abnormal_bile_duct1.05028604
98MP0010329_abnormal_lipoprotein_level1.04295463
99MP0005381_digestive/alimentary_phenotyp1.04118270
100MP0004019_abnormal_vitamin_homeostasis1.04020775
101MP0009278_abnormal_bone_marrow1.03818099
102MP0010368_abnormal_lymphatic_system1.03124599
103MP0002896_abnormal_bone_mineralization1.02750336
104MP0003806_abnormal_nucleotide_metabolis1.01459856
105MP0000767_abnormal_smooth_muscle1.00897621
106MP0002089_abnormal_postnatal_growth/wei0.99827647
107MP0001216_abnormal_epidermal_layer0.99739438
108MP0004185_abnormal_adipocyte_glucose0.99013048
109MP0009643_abnormal_urine_homeostasis0.98599992
110MP0005220_abnormal_exocrine_pancreas0.98420820
111MP0004957_abnormal_blastocyst_morpholog0.97035123
112MP0005666_abnormal_adipose_tissue0.96797927
113MP0003868_abnormal_feces_composition0.96342917
114MP0003566_abnormal_cell_adhesion0.94613268
115MP0003448_altered_tumor_morphology0.93385578
116MP0002098_abnormal_vibrissa_morphology0.93204796
117MP0000003_abnormal_adipose_tissue0.93088697
118MP0005164_abnormal_response_to0.92532750
119MP0005375_adipose_tissue_phenotype0.92506519
120MP0000462_abnormal_digestive_system0.91698031
121MP0003075_altered_response_to0.91578741
122MP0005075_abnormal_melanosome_morpholog0.91362775
123MP0009053_abnormal_anal_canal0.90450763
124MP0002998_abnormal_bone_remodeling0.90197607
125MP0002933_joint_inflammation0.89983942
126MP0005319_abnormal_enzyme/_coenzyme0.88566188
127MP0002118_abnormal_lipid_homeostasis0.88204159
128MP0000598_abnormal_liver_morphology0.87639503
129MP0004782_abnormal_surfactant_physiolog0.87205749
130MP0005166_decreased_susceptibility_to0.85497536
131MP0005023_abnormal_wound_healing0.85213516
132MP0000538_abnormal_urinary_bladder0.83898965
133MP0001243_abnormal_dermal_layer0.83596029
134MP0001881_abnormal_mammary_gland0.82742130
135MP0005623_abnormal_meninges_morphology0.82110274
136MP0002971_abnormal_brown_adipose0.81532693
137MP0005390_skeleton_phenotype0.81058185
138MP0008004_abnormal_stomach_pH0.79606559
139MP0009931_abnormal_skin_appearance0.78830598
140MP0009764_decreased_sensitivity_to0.78756876
141MP0003705_abnormal_hypodermis_morpholog0.77942793
142MP0002876_abnormal_thyroid_physiology0.77801841
143MP0005503_abnormal_tendon_morphology0.76780866
144MP0010307_abnormal_tumor_latency0.76443289
145MP0005332_abnormal_amino_acid0.76052991
146MP0005165_increased_susceptibility_to0.74623462
147MP0003941_abnormal_skin_development0.73890603
148MP0000249_abnormal_blood_vessel0.73554231
149MP0003077_abnormal_cell_cycle0.73191564
150MP0004147_increased_porphyrin_level0.72982419
151MP0002693_abnormal_pancreas_physiology0.72897063
152MP0004510_myositis0.72188485
153MP0005636_abnormal_mineral_homeostasis0.72142927
154MP0009763_increased_sensitivity_to0.71991546
155MP0005584_abnormal_enzyme/coenzyme_acti0.71070989
156MP0005076_abnormal_cell_differentiation0.70422021
157MP0002132_abnormal_respiratory_system0.70312904
158MP0008873_increased_physiological_sensi0.70178360

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of monocarboxylic acid metabolism (HP:0010996)4.51080630
2Premature rupture of membranes (HP:0001788)4.48876176
3Thrombocytosis (HP:0001894)4.24954005
4Protrusio acetabuli (HP:0003179)4.23824077
5Deep venous thrombosis (HP:0002625)4.03448674
6Vertebral compression fractures (HP:0002953)3.93073950
7Chronic otitis media (HP:0000389)3.82672376
8IgM deficiency (HP:0002850)3.81518172
9Elevated erythrocyte sedimentation rate (HP:0003565)3.79615871
10Petechiae (HP:0000967)3.71091047
11Eczematoid dermatitis (HP:0000976)3.53767377
12Abnormal delayed hypersensitivity skin test (HP:0002963)3.52260142
13Abnormality of complement system (HP:0005339)3.49974679
14Abnormality of T cell physiology (HP:0011840)3.48617759
15Systemic lupus erythematosus (HP:0002725)3.48353072
16Recurrent abscess formation (HP:0002722)3.44725090
17Myositis (HP:0100614)3.39362857
18Complement deficiency (HP:0004431)3.37183670
19Recurrent viral infections (HP:0004429)3.29747333
20Recurrent bacterial skin infections (HP:0005406)3.18859436
21Abnormality of glutamine family amino acid metabolism (HP:0010902)3.17871508
22Atrophic scars (HP:0001075)3.16916036
23Cervical subluxation (HP:0003308)3.14417470
24Interstitial pulmonary disease (HP:0006530)3.14313175
25Pustule (HP:0200039)3.08745151
26Recurrent fungal infections (HP:0002841)3.08321460
27Nasal polyposis (HP:0100582)3.06279681
28Abnormality of T cells (HP:0002843)3.06159147
29Abnormal number of erythroid precursors (HP:0012131)2.98245557
30Gastrointestinal inflammation (HP:0004386)2.97952584
31Hemorrhage of the eye (HP:0011885)2.92548681
32Inflammation of the large intestine (HP:0002037)2.91640081
33Abnormality of cells of the erythroid lineage (HP:0012130)2.90908110
34Upper limb amyotrophy (HP:0009129)2.90602824
35Distal upper limb amyotrophy (HP:0007149)2.90602824
36Prolonged bleeding time (HP:0003010)2.85323692
37Abnormality of the nasal mucosa (HP:0000433)2.82789449
38Reduced antithrombin III activity (HP:0001976)2.81147860
39Recurrent bronchitis (HP:0002837)2.81122561
40Epistaxis (HP:0000421)2.79693493
41Flat acetabular roof (HP:0003180)2.77347299
42Autoimmune thrombocytopenia (HP:0001973)2.76313408
43Aplastic anemia (HP:0001915)2.75760172
44Vacuolated lymphocytes (HP:0001922)2.75081474
45Impaired platelet aggregation (HP:0003540)2.73909375
46Abnormal platelet function (HP:0011869)2.73909375
47Glomerulonephritis (HP:0000099)2.63959707
48Cellulitis (HP:0100658)2.63933842
49Vascular tortuosity (HP:0004948)2.60778530
50Malnutrition (HP:0004395)2.60676732
51Fragile skin (HP:0001030)2.59746589
52Abnormality of the Achilles tendon (HP:0005109)2.59129457
53Ankle contracture (HP:0006466)2.58663410
54Meningitis (HP:0001287)2.57923301
55Xanthomatosis (HP:0000991)2.56414866
56Panhypogammaglobulinemia (HP:0003139)2.53132310
57Blue sclerae (HP:0000592)2.52476674
58Arterial tortuosity (HP:0005116)2.51699827
59Mucopolysacchariduria (HP:0008155)2.51698004
60Urinary glycosaminoglycan excretion (HP:0003541)2.51698004
61Recurrent skin infections (HP:0001581)2.50444873
62T lymphocytopenia (HP:0005403)2.50315147
63Achilles tendon contracture (HP:0001771)2.49378824
64Colitis (HP:0002583)2.41062521
65Chest pain (HP:0100749)2.40580273
66Gingival bleeding (HP:0000225)2.38561857
67Hand muscle atrophy (HP:0009130)2.37046865
68Abnormal platelet volume (HP:0011876)2.36694364
69Spontaneous hematomas (HP:0007420)2.36612221
70Abnormality of T cell number (HP:0011839)2.36136419
71Aortic dissection (HP:0002647)2.35322295
72Dysostosis multiplex (HP:0000943)2.34736060
73Abnormality of carpal bone ossification (HP:0006257)2.33476305
74Abnormality of polysaccharide metabolism (HP:0011012)2.28750879
75Abnormality of glycosaminoglycan metabolism (HP:0004371)2.28750879
76Abnormality of mucopolysaccharide metabolism (HP:0011020)2.28750879
77Cerebral aneurysm (HP:0004944)2.27609712
78Distal lower limb muscle weakness (HP:0009053)2.25651736
79Abnormality of the distal phalanges of the toes (HP:0010182)2.24432894
80Mildly elevated creatine phosphokinase (HP:0008180)2.23015426
81Increased IgE level (HP:0003212)2.22295052
82Abnormal protein glycosylation (HP:0012346)2.21656085
83Abnormal glycosylation (HP:0012345)2.21656085
84Abnormal isoelectric focusing of serum transferrin (HP:0003160)2.21656085
85Abnormal protein N-linked glycosylation (HP:0012347)2.21656085
86Abnormality of macrophages (HP:0004311)2.19886522
87Abnormality of cells of the lymphoid lineage (HP:0012140)2.19739765
88Cardiovascular calcification (HP:0011915)2.19652024
89Chronic mucocutaneous candidiasis (HP:0002728)2.19542636
90Recurrent cutaneous fungal infections (HP:0011370)2.19542636
91Lymphopenia (HP:0001888)2.19218638
92Nephritis (HP:0000123)2.18688875
93Biconcave vertebral bodies (HP:0004586)2.17376173
94Abnormality of aromatic amino acid family metabolism (HP:0004338)2.17065136
95Wormian bones (HP:0002645)2.16691553
96Fatigue (HP:0012378)2.16093075
97Abnormal gallbladder physiology (HP:0012438)2.14999621
98Cholecystitis (HP:0001082)2.14999621
99Recurrent gram-negative bacterial infections (HP:0005420)2.14722552
100B lymphocytopenia (HP:0010976)2.14701528
101Abnormality of B cell number (HP:0010975)2.14701528
102Conjugated hyperbilirubinemia (HP:0002908)2.14503626
103Abnormality of glycolipid metabolism (HP:0010969)2.14499975
104Abnormality of liposaccharide metabolism (HP:0010968)2.14499975
105Abnormality of glycosphingolipid metabolism (HP:0004343)2.14499975
106Chronic diarrhea (HP:0002028)2.14163761
107Distal lower limb amyotrophy (HP:0008944)2.13516490
108Type I transferrin isoform profile (HP:0003642)2.10971948
109Agammaglobulinemia (HP:0004432)2.09945750
110Vascular calcification (HP:0004934)2.09263772
111Hydroxyprolinuria (HP:0003080)2.08403380
112Abnormality of proline metabolism (HP:0010907)2.08403380
113Increased connective tissue (HP:0009025)2.06249601
114Peritonitis (HP:0002586)2.05237866
115Abnormal ossification of hand bones (HP:0005921)2.05173887
116Osteolytic defects of the hand bones (HP:0009699)2.04485366
117Osteolytic defects of the phalanges of the hand (HP:0009771)2.04485366
118J-shaped sella turcica (HP:0002680)2.03751785
119Increased mean platelet volume (HP:0011877)2.03171509
120Abnormality of pyrimidine metabolism (HP:0004353)2.02949890
121Disproportionate tall stature (HP:0001519)2.02535836
122Spinal rigidity (HP:0003306)2.02534324
123Thoracic kyphosis (HP:0002942)2.01754880
124Short nail (HP:0001799)2.01221186
125Hypertriglyceridemia (HP:0002155)2.01054121
126Verrucae (HP:0200043)1.98655464
127Papilloma (HP:0012740)1.98655464
128Genu recurvatum (HP:0002816)1.98640588
129Vasculitis (HP:0002633)1.98043348
130Dilatation of the ascending aorta (HP:0005111)1.97885758
131Hyperparathyroidism (HP:0000843)1.97860429
132Intrahepatic cholestasis (HP:0001406)1.97709594
133Elevated alkaline phosphatase (HP:0003155)1.97679317
134Loss of speech (HP:0002371)1.97390258
135Chronic obstructive pulmonary disease (HP:0006510)1.96138021
136Obstructive lung disease (HP:0006536)1.96138021
137Coxa vara (HP:0002812)1.95455500
138Purpura (HP:0000979)1.95206224
139Acanthosis nigricans (HP:0000956)1.93754580
140Back pain (HP:0003418)1.93508096
141Orchitis (HP:0100796)1.93493248
142Mitral stenosis (HP:0001718)1.93058366
143Menorrhagia (HP:0000132)1.91939116
144Hypobetalipoproteinemia (HP:0003563)1.91399222
145Abnormality of the acetabulum (HP:0003170)1.91113448
146Abnormality of the thoracic spine (HP:0100711)1.90607625
147Late onset (HP:0003584)1.89885152
148Abdominal distention (HP:0003270)1.89763307
149Bladder diverticulum (HP:0000015)1.89520673
150Stridor (HP:0010307)1.88809432
151Bone pain (HP:0002653)1.88636797
152Elbow flexion contracture (HP:0002987)1.87741761
153Aortic aneurysm (HP:0004942)1.87709779
154Hyperacusis (HP:0010780)1.87025636
155Increased variability in muscle fiber diameter (HP:0003557)1.85891582
156Abnormality of alkaline phosphatase activity (HP:0004379)1.85869276
157Hyperlipoproteinemia (HP:0010980)1.85683268
158Encephalitis (HP:0002383)1.84554732
159Amyloidosis (HP:0011034)1.84167332
160Nonimmune hydrops fetalis (HP:0001790)1.83654026
161Combined immunodeficiency (HP:0005387)1.83129429
162Aneurysm (HP:0002617)1.83087850
163Axonal loss (HP:0003447)1.82308955
164Urticaria (HP:0001025)1.82135013
165Skin ulcer (HP:0200042)1.81142042
166Osteomyelitis (HP:0002754)1.80490580
167Abnormal enzyme/coenzyme activity (HP:0012379)1.80357915
168Gingivitis (HP:0000230)1.79880615
169Generalized amyotrophy (HP:0003700)1.79506952
170Leukocytosis (HP:0001974)1.79505596
171Fat malabsorption (HP:0002630)1.79212969
172Polygenic inheritance (HP:0010982)1.78497925
173Poikiloderma (HP:0001029)1.78377744
174Hemoptysis (HP:0002105)1.78220833
175Joint hemorrhage (HP:0005261)1.77914912
176Abnormality of the prostate (HP:0008775)1.77769924
177Myocardial infarction (HP:0001658)1.77245983
178Granulocytopenia (HP:0001913)1.76800338
179Ulnar bowing (HP:0003031)1.76494407
180Joint stiffness (HP:0001387)1.76423788
181Gastrointestinal stroma tumor (HP:0100723)1.76217739
182Autoimmune hemolytic anemia (HP:0001890)1.76103078
183Abnormality of the fingertips (HP:0001211)1.73972031
184Arterial thrombosis (HP:0004420)1.73639773
185Increased serum ferritin (HP:0003281)1.73228683
186Hypergammaglobulinemia (HP:0010702)1.72685505
187Reticulocytopenia (HP:0001896)1.71823575
188Pulmonary infiltrates (HP:0002113)1.71422600
189Thin bony cortex (HP:0002753)1.71063355
190Hypoglycemic coma (HP:0001325)1.70963257

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAP4K14.12177577
2ERN13.81582035
3EPHA23.50890442
4EEF2K3.36633013
5PRPF4B2.56006255
6TRIB32.41646641
7PKN22.39834994
8SMG12.39062888
9TAOK32.29660552
10ZAP702.27579343
11TYK22.18120458
12BLK2.10175870
13BTK2.05967960
14GRK61.99027922
15FLT31.98027428
16NME21.95023204
17STK101.92761097
18KIT1.89753658
19MAP3K101.79135844
20JAK31.78407540
21TEC1.77451903
22LRRK21.74062566
23ICK1.71060148
24SCYL21.69047059
25PTK21.68066632
26PDGFRA1.66919245
27TBK11.65691909
28MAP3K31.64726388
29TESK21.60297075
30EPHB21.54642978
31MET1.52447681
32TAOK21.47278786
33ARAF1.44856694
34TXK1.44114707
35DDR21.41139807
36PRKD21.39599486
37PIM21.38239149
38MAP2K31.36312385
39ITK1.35274586
40TESK11.34902530
41MYLK1.34381532
42CSF1R1.34042399
43SYK1.33399660
44IRAK41.32258279
45IKBKE1.30967591
46KDR1.27902320
47PTK61.26660369
48PAK41.21648047
49TGFBR21.19469963
50TTN1.17071280
51RPS6KB21.13785584
52CDC42BPA1.13717251
53PRKG21.13651517
54MST41.10791152
55MAPKAPK31.06653026
56RPS6KA41.06505299
57EPHB11.04769057
58PASK1.00584645
59CSK0.99767684
60MAP3K110.99398955
61MATK0.99171720
62FGFR40.97737239
63LCK0.95566335
64JAK10.94519198
65RIPK40.94423702
66FES0.94377433
67WNK30.93723664
68LIMK10.93718032
69PDPK10.93035317
70STK380.91207374
71MAP2K20.84736376
72PIM10.84510290
73PIK3CG0.83790406
74HCK0.82856951
75TGFBR10.82565934
76LATS20.81518860
77ABL20.80794471
78MAP3K80.80729484
79LYN0.80350544
80KSR20.77797548
81MTOR0.77353498
82SIK30.75781505
83MAPK110.75729400
84NTRK10.72953444
85JAK20.72260031
86HIPK20.72052422
87TAOK10.71859026
88CDK40.71312048
89NLK0.69895979
90MAP3K70.67833441
91IKBKB0.67793056
92MAP2K60.67568114
93IRAK30.66053752
94PRKD30.65945284
95MAP3K20.64989127
96EIF2AK30.64982490
97BCKDK0.64683485
98NEK90.62891776
99CDK60.61682562
100NEK20.60690538
101RIPK10.59040633
102MUSK0.58435241
103MAP3K120.58270213
104MST1R0.57536176
105MAP3K10.56712099
106LMTK20.54205225
107FRK0.53745834
108SIK10.53160073
109ILK0.51110239
110RPS6KA60.50521718
111STK160.50448219
112MAP3K140.48731660
113MAP2K10.48040778
114MARK20.47907516
115ACVR1B0.47317596
116CDK190.46775931
117MAPKAPK20.46680815
118MAPK40.46275654
119PAK20.46115735
120EPHA30.44845862
121BMX0.44110088
122PIK3CA0.42643415
123BRSK20.42484942
124CHUK0.42124879
125PRKCI0.41975394
126RPS6KC10.40200930
127RPS6KL10.40200930
128CDK70.40122084
129BRAF0.39937619
130CLK10.39675842
131PDGFRB0.39235058
132MAP3K130.38498788
133DYRK1B0.38459593
134MAP3K60.38155028
135MAPK70.37981267
136RET0.37414903
137CDK120.36810362
138RPS6KA20.36710561
139PDK10.36111846
140TRPM70.35782478
141WEE10.35284482
142SRC0.34895111
143PAK10.34523393
144MOS0.32670997
145ROCK20.32135167
146DAPK30.31740247
147LATS10.31523529
148CAMK2G0.27794587

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary immunodeficiency_Homo sapiens_hsa053402.71912916
2Complement and coagulation cascades_Homo sapiens_hsa046102.50412243
3DNA replication_Homo sapiens_hsa030302.38588477
4Leishmaniasis_Homo sapiens_hsa051402.22294072
5Phenylalanine metabolism_Homo sapiens_hsa003602.15502563
6Arginine biosynthesis_Homo sapiens_hsa002202.12165927
7Ribosome_Homo sapiens_hsa030102.09671308
8Antigen processing and presentation_Homo sapiens_hsa046122.05196674
9Other glycan degradation_Homo sapiens_hsa005112.03071986
10Pentose phosphate pathway_Homo sapiens_hsa000301.87413515
11Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.80558197
12Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.78589860
13B cell receptor signaling pathway_Homo sapiens_hsa046621.78331446
14Caffeine metabolism_Homo sapiens_hsa002321.75278300
15N-Glycan biosynthesis_Homo sapiens_hsa005101.74029624
16Retinol metabolism_Homo sapiens_hsa008301.73703761
172-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.67191350
18Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.63064307
19Intestinal immune network for IgA production_Homo sapiens_hsa046721.62833700
20Folate biosynthesis_Homo sapiens_hsa007901.59497133
21PPAR signaling pathway_Homo sapiens_hsa033201.58934743
22Chemical carcinogenesis_Homo sapiens_hsa052041.58772713
23Maturity onset diabetes of the young_Homo sapiens_hsa049501.57183760
24Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.55960770
25Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.54831779
26Hematopoietic cell lineage_Homo sapiens_hsa046401.53685581
27Prion diseases_Homo sapiens_hsa050201.52201610
28Osteoclast differentiation_Homo sapiens_hsa043801.51157710
29RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.49393766
30Measles_Homo sapiens_hsa051621.47263962
31Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.45132501
32Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.42943869
33Sulfur relay system_Homo sapiens_hsa041221.42242040
34Steroid hormone biosynthesis_Homo sapiens_hsa001401.41316856
35Galactose metabolism_Homo sapiens_hsa000521.40314619
36Bile secretion_Homo sapiens_hsa049761.40195072
37Glycosaminoglycan degradation_Homo sapiens_hsa005311.36102266
38Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.34101282
39Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.33761324
40NF-kappa B signaling pathway_Homo sapiens_hsa040641.33554823
41Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.33282838
42Primary bile acid biosynthesis_Homo sapiens_hsa001201.32381279
43Legionellosis_Homo sapiens_hsa051341.32280374
44Acute myeloid leukemia_Homo sapiens_hsa052211.30623073
45Fat digestion and absorption_Homo sapiens_hsa049751.30035217
46Mismatch repair_Homo sapiens_hsa034301.28918211
47Renin-angiotensin system_Homo sapiens_hsa046141.28709927
48Protein export_Homo sapiens_hsa030601.27988677
49Tyrosine metabolism_Homo sapiens_hsa003501.23968704
50Toxoplasmosis_Homo sapiens_hsa051451.22139977
51Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.22004229
52Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.19549347
53Herpes simplex infection_Homo sapiens_hsa051681.19074861
54Toll-like receptor signaling pathway_Homo sapiens_hsa046201.17375562
55Leukocyte transendothelial migration_Homo sapiens_hsa046701.16780074
56Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.16645059
57Shigellosis_Homo sapiens_hsa051311.16233730
58Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.14443441
59Pentose and glucuronate interconversions_Homo sapiens_hsa000401.13292432
60Pertussis_Homo sapiens_hsa051331.13174522
61Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.11883196
62Selenocompound metabolism_Homo sapiens_hsa004501.09720234
63Base excision repair_Homo sapiens_hsa034101.09645078
64Protein digestion and absorption_Homo sapiens_hsa049741.09151824
65Drug metabolism - other enzymes_Homo sapiens_hsa009831.08620495
66T cell receptor signaling pathway_Homo sapiens_hsa046601.06381020
67Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.05942432
68Amoebiasis_Homo sapiens_hsa051461.05528501
69Apoptosis_Homo sapiens_hsa042101.04321717
70Staphylococcus aureus infection_Homo sapiens_hsa051501.03168788
71Influenza A_Homo sapiens_hsa051641.03020242
72Hepatitis B_Homo sapiens_hsa051611.02349591
73Vibrio cholerae infection_Homo sapiens_hsa051101.01808141
74Jak-STAT signaling pathway_Homo sapiens_hsa046300.99586670
75Cyanoamino acid metabolism_Homo sapiens_hsa004600.97943004
76Sulfur metabolism_Homo sapiens_hsa009200.97629910
77Platelet activation_Homo sapiens_hsa046110.95206563
78Bladder cancer_Homo sapiens_hsa052190.94143427
79Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.93966852
80Chronic myeloid leukemia_Homo sapiens_hsa052200.93733752
81One carbon pool by folate_Homo sapiens_hsa006700.92820576
82Thyroid cancer_Homo sapiens_hsa052160.91452344
83ECM-receptor interaction_Homo sapiens_hsa045120.91390668
84NOD-like receptor signaling pathway_Homo sapiens_hsa046210.90026993
85Tuberculosis_Homo sapiens_hsa051520.88809439
86Sphingolipid metabolism_Homo sapiens_hsa006000.88368067
87Arginine and proline metabolism_Homo sapiens_hsa003300.87377418
88Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.87090865
89Focal adhesion_Homo sapiens_hsa045100.87090765
90Fructose and mannose metabolism_Homo sapiens_hsa000510.86147777
91Starch and sucrose metabolism_Homo sapiens_hsa005000.86119072
92Carbohydrate digestion and absorption_Homo sapiens_hsa049730.85480319
93Lysosome_Homo sapiens_hsa041420.81814694
94Central carbon metabolism in cancer_Homo sapiens_hsa052300.81029465
95Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.80400851
96Hepatitis C_Homo sapiens_hsa051600.80301155
97Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.79385533
98Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.77086249
99Glycerolipid metabolism_Homo sapiens_hsa005610.76787211
100Glutathione metabolism_Homo sapiens_hsa004800.74769472
101Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.70806278
102Fatty acid degradation_Homo sapiens_hsa000710.70473967
103Histidine metabolism_Homo sapiens_hsa003400.68729376
104Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.67992711
105TNF signaling pathway_Homo sapiens_hsa046680.67869359
106ABC transporters_Homo sapiens_hsa020100.67853906
107Pancreatic cancer_Homo sapiens_hsa052120.66676537
108Pyrimidine metabolism_Homo sapiens_hsa002400.63718397
109Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.62308497
110Salmonella infection_Homo sapiens_hsa051320.61585771
111Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.60128513
112Carbon metabolism_Homo sapiens_hsa012000.59430475
113Mineral absorption_Homo sapiens_hsa049780.58995926
114Transcriptional misregulation in cancer_Homo sapiens_hsa052020.58177585
115Notch signaling pathway_Homo sapiens_hsa043300.58156430
116Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.57956927
117Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.57757759
118Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.57588320
119Tryptophan metabolism_Homo sapiens_hsa003800.56777885
120Pyruvate metabolism_Homo sapiens_hsa006200.55621999
121AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.55271325
122Proteoglycans in cancer_Homo sapiens_hsa052050.55215858
123Neurotrophin signaling pathway_Homo sapiens_hsa047220.53734002
124Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.53544598
125Adipocytokine signaling pathway_Homo sapiens_hsa049200.52606839
126Endocytosis_Homo sapiens_hsa041440.52395261
127Arachidonic acid metabolism_Homo sapiens_hsa005900.51708949
128Viral carcinogenesis_Homo sapiens_hsa052030.51241694
129Vitamin B6 metabolism_Homo sapiens_hsa007500.51021694
130Insulin resistance_Homo sapiens_hsa049310.49537645
131Biosynthesis of amino acids_Homo sapiens_hsa012300.49306869
132AMPK signaling pathway_Homo sapiens_hsa041520.47927677
133Viral myocarditis_Homo sapiens_hsa054160.47129871
134Insulin signaling pathway_Homo sapiens_hsa049100.47030356
135beta-Alanine metabolism_Homo sapiens_hsa004100.47000531
136Non-small cell lung cancer_Homo sapiens_hsa052230.46472558
137p53 signaling pathway_Homo sapiens_hsa041150.45245829
138Endometrial cancer_Homo sapiens_hsa052130.44886701
139Chemokine signaling pathway_Homo sapiens_hsa040620.43177940
140Homologous recombination_Homo sapiens_hsa034400.41109271
141VEGF signaling pathway_Homo sapiens_hsa043700.39616902
142Vitamin digestion and absorption_Homo sapiens_hsa049770.39370906
143Regulation of actin cytoskeleton_Homo sapiens_hsa048100.39244705
144Small cell lung cancer_Homo sapiens_hsa052220.39015291
145Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.38687026
146Peroxisome_Homo sapiens_hsa041460.33391377
147Fatty acid metabolism_Homo sapiens_hsa012120.31785275

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