SLC35C2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the triose-phosphate transporter protein family. This gene is regulated by oxygen tension, is induced in hypoxic trophoblast cells, and is overexpressed in ovarian cancer. Alternative splicing results in multiple transcript variants. A pseudogene of this gene has been defined on the X chromosome. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1neutrophil mediated immunity (GO:0002446)4.81617234
2killing of cells in other organism involved in symbiotic interaction (GO:0051883)4.47990965
3disruption of cells of other organism involved in symbiotic interaction (GO:0051818)4.47990965
4DNA deamination (GO:0045006)4.37208332
5positive regulation of B cell differentiation (GO:0045579)4.16887910
6ribosomal small subunit assembly (GO:0000028)4.08831324
7intestinal cholesterol absorption (GO:0030299)4.08519287
8antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)3.90949014
9antigen processing and presentation of endogenous peptide antigen (GO:0002483)3.90949014
10amyloid precursor protein catabolic process (GO:0042987)3.84002266
11negative regulation of phagocytosis (GO:0050765)3.82018769
12positive regulation of type I interferon-mediated signaling pathway (GO:0060340)3.79186815
13COPI coating of Golgi vesicle (GO:0048205)3.76019191
14Golgi transport vesicle coating (GO:0048200)3.76019191
15antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G3.71534117
16protein retention in ER lumen (GO:0006621)3.70095977
17regulation of B cell receptor signaling pathway (GO:0050855)3.70009046
18myeloid leukocyte mediated immunity (GO:0002444)3.66626918
19antigen processing and presentation of endogenous antigen (GO:0019883)3.58603353
20endosome to pigment granule transport (GO:0043485)3.55671676
21endosome to melanosome transport (GO:0035646)3.55671676
22disruption of cells of other organism (GO:0044364)3.52975564
23killing of cells of other organism (GO:0031640)3.52975564
24deoxyribonucleoside monophosphate metabolic process (GO:0009162)3.49783157
25maintenance of protein localization in endoplasmic reticulum (GO:0035437)3.48522961
26defense response to fungus (GO:0050832)3.47740450
27positive regulation of gamma-delta T cell activation (GO:0046645)3.45440456
28leukotriene biosynthetic process (GO:0019370)3.43461309
29mannose metabolic process (GO:0006013)3.40517996
30regulation of B cell differentiation (GO:0045577)3.39486787
31interferon-gamma secretion (GO:0072643)3.34753836
32regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450913.31117350
33modulation by symbiont of host immune response (GO:0052553)3.30861532
34positive regulation by symbiont of host defense response (GO:0052509)3.30861532
35modulation by symbiont of host defense response (GO:0052031)3.30861532
36modulation by organism of immune response of other organism involved in symbiotic interaction (GO:003.30861532
37modulation by organism of defense response of other organism involved in symbiotic interaction (GO:03.30861532
38positive regulation by organism of defense response of other organism involved in symbiotic interact3.30861532
39negative regulation of cell killing (GO:0031342)3.28693267
40negative regulation of leukocyte mediated cytotoxicity (GO:0001911)3.28693267
41signal peptide processing (GO:0006465)3.24737700
42pentose-phosphate shunt (GO:0006098)3.24719395
43response to fungus (GO:0009620)3.24640716
44antigen processing and presentation via MHC class Ib (GO:0002475)3.20778771
45immunoglobulin mediated immune response (GO:0016064)3.18982578
46platelet dense granule organization (GO:0060155)3.13311933
47megakaryocyte development (GO:0035855)3.10666826
48thymic T cell selection (GO:0045061)3.06371706
49respiratory burst (GO:0045730)3.05399119
50Arp2/3 complex-mediated actin nucleation (GO:0034314)3.04287319
51fucose catabolic process (GO:0019317)3.03497175
52L-fucose metabolic process (GO:0042354)3.03497175
53L-fucose catabolic process (GO:0042355)3.03497175
54mast cell activation (GO:0045576)3.03251525
55negative regulation of lipopolysaccharide-mediated signaling pathway (GO:0031665)3.02834239
56purine nucleotide salvage (GO:0032261)3.02518774
57negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)3.02397256
58peptide catabolic process (GO:0043171)3.00931746
59NIK/NF-kappaB signaling (GO:0038061)2.97135938
60glycolipid catabolic process (GO:0019377)2.94518119
61SRP-dependent cotranslational protein targeting to membrane (GO:0006614)2.93189861
62L-serine metabolic process (GO:0006563)2.92462580
63leukocyte aggregation (GO:0070486)2.92185559
64modulation of growth of symbiont involved in interaction with host (GO:0044144)2.91739901
65regulation of growth of symbiont in host (GO:0044126)2.91739901
66negative regulation of growth of symbiont in host (GO:0044130)2.91739901
67negative regulation of growth of symbiont involved in interaction with host (GO:0044146)2.91739901
68positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)2.89945220
69negative thymic T cell selection (GO:0045060)2.88632149
70mature B cell differentiation involved in immune response (GO:0002313)2.87777202
71T cell migration (GO:0072678)2.86968009
72cotranslational protein targeting to membrane (GO:0006613)2.86816027
73regulation of gamma-delta T cell activation (GO:0046643)2.86244815
74leukotriene metabolic process (GO:0006691)2.86045990
75regulation of antigen processing and presentation of peptide antigen (GO:0002583)2.85421260
76response to type I interferon (GO:0034340)2.84845464
77modulation by virus of host process (GO:0019054)2.83554548
78telomere maintenance via semi-conservative replication (GO:0032201)2.83442266
79protein targeting to ER (GO:0045047)2.83432465
80positive thymic T cell selection (GO:0045059)2.82950626
81mitochondrial calcium ion transport (GO:0006851)2.82471270
82response to interferon-beta (GO:0035456)2.81492169
83type I interferon signaling pathway (GO:0060337)2.81189091
84cellular response to type I interferon (GO:0071357)2.81189091
85NADPH regeneration (GO:0006740)2.80756013
86purine-containing compound salvage (GO:0043101)2.79310918
87amyloid precursor protein metabolic process (GO:0042982)2.78990017
88detection of bacterium (GO:0016045)2.78960939
89proline biosynthetic process (GO:0006561)2.77710964
90protein localization to endoplasmic reticulum (GO:0070972)2.77484138
91pinocytosis (GO:0006907)2.77099940
92negative regulation of innate immune response (GO:0045824)2.76787237
93negative regulation of myeloid cell apoptotic process (GO:0033033)2.76515946
94exocrine pancreas development (GO:0031017)2.76339735
95regulation of histone H3-K27 methylation (GO:0061085)2.76073156
96GDP-mannose metabolic process (GO:0019673)2.75556684
97defense response to protozoan (GO:0042832)2.73390570
98angiotensin maturation (GO:0002003)2.72618951
99negative T cell selection (GO:0043383)2.69065918
100cellular response to virus (GO:0098586)2.67909974
101T cell selection (GO:0045058)2.66881877
102digestion (GO:0007586)2.66707873
103negative regulation of erythrocyte differentiation (GO:0045647)2.66399323
104establishment of protein localization to endoplasmic reticulum (GO:0072599)2.66021864
105regulation of superoxide anion generation (GO:0032928)2.64877424
106protein maturation by protein folding (GO:0022417)2.63929547
107regulation of interferon-beta biosynthetic process (GO:0045357)2.63640745
108response to peptidoglycan (GO:0032494)2.63567997
109detection of other organism (GO:0098543)2.61868119
110neutrophil activation involved in immune response (GO:0002283)2.60671016
111response to protozoan (GO:0001562)2.59479699
112cellular response to interferon-beta (GO:0035458)2.58907037
113regulation of gamma-delta T cell differentiation (GO:0045586)2.58609082
114regulation of type I interferon-mediated signaling pathway (GO:0060338)2.58417083
115response to muramyl dipeptide (GO:0032495)2.57564135
116lymphocyte migration (GO:0072676)2.57317941
117negative regulation of viral release from host cell (GO:1902187)2.57293085
118macrophage differentiation (GO:0030225)2.57097442
119cellular response to exogenous dsRNA (GO:0071360)2.56655327
120viral transcription (GO:0019083)2.56582756
121response to defenses of other organism involved in symbiotic interaction (GO:0052173)2.55033832
122response to host (GO:0075136)2.55033832
123response to host defenses (GO:0052200)2.55033832
124N-acetylneuraminate metabolic process (GO:0006054)2.54303321
125DNA strand elongation involved in DNA replication (GO:0006271)2.53567884
126modulation by symbiont of host cellular process (GO:0044068)2.52265461
127serine family amino acid biosynthetic process (GO:0009070)2.52209823
128nucleobase biosynthetic process (GO:0046112)2.51944472
129positive regulation of interleukin-8 biosynthetic process (GO:0045416)2.51870581
130ceramide catabolic process (GO:0046514)2.51619085
131nucleoside salvage (GO:0043174)2.50956765
132B cell receptor signaling pathway (GO:0050853)2.50821293
133DNA strand elongation (GO:0022616)2.49804131
134tolerance induction (GO:0002507)2.49358307
135positive regulation of histone deacetylation (GO:0031065)2.48714079
136anterograde synaptic vesicle transport (GO:0048490)2.46471509
137chaperone mediated protein folding requiring cofactor (GO:0051085)2.46349361
138phosphatidylglycerol biosynthetic process (GO:0006655)2.46182992
139positive regulation of Cdc42 GTPase activity (GO:0043089)2.45750872
140negative regulation of interleukin-2 production (GO:0032703)2.45281912
141cellular response to interleukin-4 (GO:0071353)2.45002040
142L-methionine biosynthetic process from methylthioadenosine (GO:0019509)2.44589460
143cholesterol catabolic process (GO:0006707)2.44086879
144sterol catabolic process (GO:0016127)2.44086879
145negative regulation of tumor necrosis factor production (GO:0032720)2.43626656
146response to immune response of other organism involved in symbiotic interaction (GO:0052564)2.43142649
147response to host immune response (GO:0052572)2.43142649
148protein insertion into membrane (GO:0051205)2.42698051
149macrophage activation involved in immune response (GO:0002281)2.42189596
150glucose 6-phosphate metabolic process (GO:0051156)2.42139792
151regulation of myeloid leukocyte mediated immunity (GO:0002886)2.40830227
152lymphoid progenitor cell differentiation (GO:0002320)2.39739284
153negative regulation of cytokine production involved in immune response (GO:0002719)2.39387068
154positive regulation of granulocyte differentiation (GO:0030854)2.39116372
155T cell homeostasis (GO:0043029)2.39100851
156negative regulation of tumor necrosis factor superfamily cytokine production (GO:1903556)2.38555441
157leukocyte mediated cytotoxicity (GO:0001909)2.37935553
158negative regulation of B cell apoptotic process (GO:0002903)2.37913748
159translational elongation (GO:0006414)2.37211196
160translational termination (GO:0006415)2.36989409
161pentose metabolic process (GO:0019321)2.35924719
162regulation of cholesterol esterification (GO:0010872)2.34110171
163regulation of mammary gland epithelial cell proliferation (GO:0033599)2.32864125
164CD4-positive or CD8-positive, alpha-beta T cell lineage commitment (GO:0043369)2.32572818
165positive regulation of interleukin-2 biosynthetic process (GO:0045086)2.32154226
166regulation of leukocyte degranulation (GO:0043300)2.31327461
167positive regulation of T cell mediated cytotoxicity (GO:0001916)2.30701998
168G-protein coupled purinergic nucleotide receptor signaling pathway (GO:0035589)2.28342101
169regulation of mast cell degranulation (GO:0043304)2.28250607
170negative regulation of interleukin-6 production (GO:0032715)2.27758596
171response to interleukin-4 (GO:0070670)2.26509119
172amino sugar catabolic process (GO:0046348)2.26110715
173regulation of dendritic cell antigen processing and presentation (GO:0002604)2.25714027

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1* EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.30402862
2NOTCH1_17114293_ChIP-ChIP_T-ALL_Human3.23851599
3* MECOM_23826213_ChIP-Seq_KASUMI_Mouse3.17117372
4IRF8_21731497_ChIP-ChIP_J774_Mouse3.03431928
5ELF1_17652178_ChIP-ChIP_JURKAT_Human3.02502740
6RUNX1_20887958_ChIP-Seq_HPC-7_Mouse3.02165923
7IRF8_22096565_ChIP-ChIP_GC-B_Human2.97791260
8SCL_19346495_ChIP-Seq_HPC-7_Human2.88838276
9SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse2.88201208
10FLI1_20887958_ChIP-Seq_HPC-7_Mouse2.71279993
11TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.62002412
12VDR_21846776_ChIP-Seq_THP-1_Human2.55205919
13JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.55082891
14SPI1_22096565_ChIP-ChIP_GC-B_Mouse2.52947976
15SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.52879883
16E2F7_22180533_ChIP-Seq_HELA_Human2.51903637
17IRF8_22096565_ChIP-ChIP_GC-B_Mouse2.45335250
18MYB_21317192_ChIP-Seq_ERMYB_Mouse2.37454361
19SPI1_23547873_ChIP-Seq_NB4_Human2.33013072
20NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human2.29373898
21TAL1_20887958_ChIP-Seq_HPC-7_Mouse2.21465621
22KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.20533156
23MYC_22102868_ChIP-Seq_BL_Human2.20138569
24LYL1_20887958_ChIP-Seq_HPC-7_Mouse2.15923503
25* GABP_17652178_ChIP-ChIP_JURKAT_Human2.10740490
26ELK3_25401928_ChIP-Seq_HUVEC_Human2.10236632
27* MYC_18555785_ChIP-Seq_MESCs_Mouse2.09131418
28SFPI1_20887958_ChIP-Seq_HPC-7_Mouse2.08802548
29MEIS1_20887958_ChIP-Seq_HPC-7_Mouse2.08229381
30HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.07465390
31* MYC_18358816_ChIP-ChIP_MESCs_Mouse2.06280517
32ERG_20887958_ChIP-Seq_HPC-7_Mouse2.02619061
33ETS1_20019798_ChIP-Seq_JURKAT_Human2.01647236
34LMO2_20887958_ChIP-Seq_HPC-7_Mouse2.00779206
35EST1_17652178_ChIP-ChIP_JURKAT_Human2.00564903
36PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.97370291
37KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.89354874
38CIITA_25753668_ChIP-Seq_RAJI_Human1.84030194
39KDM2B_26808549_Chip-Seq_SUP-B15_Human1.77894969
40CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.77213128
41RACK7_27058665_Chip-Seq_MCF-7_Human1.73651478
42VDR_24763502_ChIP-Seq_THP-1_Human1.73052466
43GATA1_22383799_ChIP-Seq_G1ME_Mouse1.71451031
44P68_20966046_ChIP-Seq_HELA_Human1.70973809
45RARG_19884340_ChIP-ChIP_MEFs_Mouse1.70123078
46HOXB4_20404135_ChIP-ChIP_EML_Mouse1.69219620
47IRF8_27001747_Chip-Seq_BMDM_Mouse1.68876686
48SRF_21415370_ChIP-Seq_HL-1_Mouse1.68241165
49* VDR_23849224_ChIP-Seq_CD4+_Human1.66833267
50TET1_21451524_ChIP-Seq_MESCs_Mouse1.66522757
51GFI1B_20887958_ChIP-Seq_HPC-7_Mouse1.66471039
52TCF7_22412390_ChIP-Seq_EML_Mouse1.66449593
53* RUNX1_22412390_ChIP-Seq_EML_Mouse1.66252180
54E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.64906649
55GATA1_22025678_ChIP-Seq_K562_Human1.64583164
56ELF1_20517297_ChIP-Seq_JURKAT_Human1.64240092
57SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.62874819
58FOXP3_21729870_ChIP-Seq_TREG_Human1.62844129
59GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.60599646
60* BRD4_27068464_Chip-Seq_AML-cells_Mouse1.59457774
61DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.58526013
62CREB1_15753290_ChIP-ChIP_HEK293T_Human1.57468081
63ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.54866505
64* GABP_19822575_ChIP-Seq_HepG2_Human1.53976600
65KDM2B_26808549_Chip-Seq_DND41_Human1.53828725
66NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.52757316
67THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.51810757
68NOTCH1_21737748_ChIP-Seq_TLL_Human1.51189919
69SA1_27219007_Chip-Seq_ERYTHROID_Human1.50912602
70PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.50588910
71THAP11_20581084_ChIP-Seq_MESCs_Mouse1.47753514
72SRY_22984422_ChIP-ChIP_TESTIS_Rat1.46000200
73ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.44957648
74CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.40659055
75FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.40626152
76MYB_26560356_Chip-Seq_TH2_Human1.38202283
77CTCF_27219007_Chip-Seq_ERYTHROID_Human1.38200025
78PU.1_20513432_ChIP-Seq_Bcells_Mouse1.37675264
79* MYC_19030024_ChIP-ChIP_MESCs_Mouse1.36615389
80GATA2_22383799_ChIP-Seq_G1ME_Mouse1.35937793
81CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.35541586
82* MAF_26560356_Chip-Seq_TH1_Human1.35129465
83XRN2_22483619_ChIP-Seq_HELA_Human1.34989701
84STAT4_19710469_ChIP-ChIP_TH1__Mouse1.34806372
85KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.33844005
86HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.33070173
87SMC4_20622854_ChIP-Seq_HELA_Human1.32925429
88CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.32142712
89BCL6_27268052_Chip-Seq_Bcells_Human1.29404316
90PPARA_22158963_ChIP-Seq_LIVER_Mouse1.28365719
91UTX_26944678_Chip-Seq_JUKART_Human1.27862930
92YY1_21170310_ChIP-Seq_MESCs_Mouse1.27270323
93GATA1_19941827_ChIP-Seq_MEL_Mouse1.26997830
94SPI1_23127762_ChIP-Seq_K562_Human1.26380584
95DCP1A_22483619_ChIP-Seq_HELA_Human1.26146241
96TP63_17297297_ChIP-ChIP_HaCaT_Human1.26110362
97MYB_26560356_Chip-Seq_TH1_Human1.25526209
98PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.22779404
99NCOR1_26117541_ChIP-Seq_K562_Human1.22612361
100E2F1_18555785_ChIP-Seq_MESCs_Mouse1.22490960
101CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.21658000
102* CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.21328808
103E2F1_20622854_ChIP-Seq_HELA_Human1.21324431
104CTCF_26484167_Chip-Seq_Bcells_Mouse1.19469030
105STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.18365641
106PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse1.17920464
107SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.15602843
108SREBP2_21459322_ChIP-Seq_LIVER_Mouse1.15303633
109STAT6_21828071_ChIP-Seq_BEAS2B_Human1.15231949
110SMAD2/3_21741376_ChIP-Seq_ESCs_Human1.13770246
111BP1_19119308_ChIP-ChIP_Hs578T_Human1.13739490
112CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.13634820
113* SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.13162309
114CTCF_21964334_Chip-Seq_Bcells_Human1.12606010
115RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.12308568
116TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.12033044
117PHF8_20622854_ChIP-Seq_HELA_Human1.11999515
118SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.11815711
119* FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.10092196
120EGR1_19374776_ChIP-ChIP_THP-1_Human1.09598810
121* SA1_27219007_Chip-Seq_Bcells_Human1.08865587
122MYC_19079543_ChIP-ChIP_MESCs_Mouse1.08815651
123TFEB_21752829_ChIP-Seq_HELA_Human1.08150157
124* LXR_22292898_ChIP-Seq_THP-1_Human1.08006310
125RXR_22158963_ChIP-Seq_LIVER_Mouse1.07627598
126YY1_22570637_ChIP-Seq_MALME-3M_Human1.06706374
127KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.05279616
128CTCF_21964334_ChIP-Seq_BJAB-B_Human1.03493564
129TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.03299834
130BCOR_27268052_Chip-Seq_Bcells_Human1.02863607
131CREB1_26743006_Chip-Seq_LNCaP_Human1.02149850
132MAF_26560356_Chip-Seq_TH2_Human1.01718287
133RARB_24833708_ChIP-Seq_LIVER_Mouse1.01711015
134CTCF_18555785_ChIP-Seq_MESCs_Mouse1.01479438
135CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse1.01246307
136EBNA2_21746931_ChIP-Seq_IB4-LCL_Human1.00996889
137RBPJ_21746931_ChIP-Seq_IB4-LCL_Human0.98177760
138TTF2_22483619_ChIP-Seq_HELA_Human0.98067413
139DMRT1_21621532_ChIP-ChIP_FETAL_Ovary0.94620260
140CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse0.93704101
141STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse0.93147883

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002396_abnormal_hematopoietic_system3.36599047
2MP0001835_abnormal_antigen_presentation3.27363793
3MP0003183_abnormal_peptide_metabolism3.00920700
4MP0003172_abnormal_lysosome_physiology2.97859271
5MP0001666_abnormal_nutrient_absorption2.92037408
6MP0005464_abnormal_platelet_physiology2.86165122
7MP0005671_abnormal_response_to2.84917811
8MP0003436_decreased_susceptibility_to2.70145183
9MP0005451_abnormal_body_composition2.65630119
10MP0009840_abnormal_foam_cell2.60511045
11MP0005058_abnormal_lysosome_morphology2.44217544
12MP0009785_altered_susceptibility_to2.41657997
13MP0005174_abnormal_tail_pigmentation2.34433119
14MP0002419_abnormal_innate_immunity2.33487994
15MP0008260_abnormal_autophagy2.24403290
16MP0005083_abnormal_biliary_tract2.15329863
17MP0005025_abnormal_response_to2.13565669
18MP0000465_gastrointestinal_hemorrhage2.12539788
19MP0000490_abnormal_crypts_of2.09474118
20MP0000685_abnormal_immune_system2.05965548
21MP0004381_abnormal_hair_follicle2.05305259
22MP0001873_stomach_inflammation2.04920364
23MP0005220_abnormal_exocrine_pancreas2.03820470
24MP0005365_abnormal_bile_salt2.03515240
25MP0002420_abnormal_adaptive_immunity2.01013920
26MP0001800_abnormal_humoral_immune2.00324577
27MP0005000_abnormal_immune_tolerance1.99404351
28MP0001819_abnormal_immune_cell1.96812265
29MP0002148_abnormal_hypersensitivity_rea1.96523894
30MP0005075_abnormal_melanosome_morpholog1.94607653
31MP0002452_abnormal_antigen_presenting1.93612204
32MP0002723_abnormal_immune_serum1.92014479
33MP0002398_abnormal_bone_marrow1.83771848
34MP0004947_skin_inflammation1.81772338
35MP0000689_abnormal_spleen_morphology1.74016475
36MP0004264_abnormal_extraembryonic_tissu1.72976893
37MP0000716_abnormal_immune_system1.70536281
38MP0004147_increased_porphyrin_level1.68666380
39MP0004808_abnormal_hematopoietic_stem1.67676937
40MP0000015_abnormal_ear_pigmentation1.67561145
41MP0005360_urolithiasis1.66004563
42MP0001845_abnormal_inflammatory_respons1.64482131
43MP0005084_abnormal_gallbladder_morpholo1.63728811
44MP0009333_abnormal_splenocyte_physiolog1.63245391
45MP0003191_abnormal_cellular_cholesterol1.61096826
46MP0002429_abnormal_blood_cell1.59146991
47MP0002722_abnormal_immune_system1.57885905
48MP0003763_abnormal_thymus_physiology1.57745163
49MP0003866_abnormal_defecation1.57290860
50MP0005387_immune_system_phenotype1.54722908
51MP0001790_abnormal_immune_system1.54722908
52MP0003656_abnormal_erythrocyte_physiolo1.49653695
53MP0010155_abnormal_intestine_physiology1.48295094
54MP0002405_respiratory_system_inflammati1.44385272
55MP0003806_abnormal_nucleotide_metabolis1.43745511
56MP0008469_abnormal_protein_level1.40665547
57MP0003303_peritoneal_inflammation1.39138522
58MP0001986_abnormal_taste_sensitivity1.38335975
59MP0004858_abnormal_nervous_system1.37040060
60MP0006036_abnormal_mitochondrial_physio1.29972418
61MP0001545_abnormal_hematopoietic_system1.26765130
62MP0005397_hematopoietic_system_phenotyp1.26765130
63MP0003724_increased_susceptibility_to1.25920753
64MP0001663_abnormal_digestive_system1.25479450
65MP0000858_altered_metastatic_potential1.23467720
66MP0003300_gastrointestinal_ulcer1.22131628
67MP0001764_abnormal_homeostasis1.22062514
68MP0002132_abnormal_respiratory_system1.20812930
69MP0001533_abnormal_skeleton_physiology1.20715569
70MP0006082_CNS_inflammation1.18206175
71MP0002095_abnormal_skin_pigmentation1.17354756
72MP0002166_altered_tumor_susceptibility1.15488938
73MP0003693_abnormal_embryo_hatching1.14905287
74MP0010329_abnormal_lipoprotein_level1.13589678
75MP0001853_heart_inflammation1.11222309
76MP0008875_abnormal_xenobiotic_pharmacok1.10874971
77MP0000609_abnormal_liver_physiology1.10136043
78MP0002693_abnormal_pancreas_physiology1.09111512
79MP0006054_spinal_hemorrhage1.08934010
80MP0003868_abnormal_feces_composition1.08829713
81MP0002139_abnormal_hepatobiliary_system1.07352672
82MP0006292_abnormal_olfactory_placode1.07099659
83MP0005085_abnormal_gallbladder_physiolo1.06519693
84MP0000343_altered_response_to1.04519073
85MP0003638_abnormal_response/metabolism_1.02844025
86MP0009764_decreased_sensitivity_to1.02139036
87MP0000678_abnormal_parathyroid_gland0.95732430
88MP0005310_abnormal_salivary_gland0.95661580
89MP0001664_abnormal_digestion0.95488857
90MP0005501_abnormal_skin_physiology0.94076888
91MP0000703_abnormal_thymus_morphology0.93534766
92MP0008004_abnormal_stomach_pH0.93265414
93MP0002089_abnormal_postnatal_growth/wei0.92300094
94MP0003075_altered_response_to0.90445685
95MP0003453_abnormal_keratinocyte_physiol0.89636399
96MP0002796_impaired_skin_barrier0.89417847
97MP0003329_amyloid_beta_deposits0.89019947
98MP0002933_joint_inflammation0.87663352
99MP0003011_delayed_dark_adaptation0.87374238
100MP0005076_abnormal_cell_differentiation0.85876517
101MP0001849_ear_inflammation0.85487866
102MP0009931_abnormal_skin_appearance0.82696097
103MP0005332_abnormal_amino_acid0.81959196
104MP0004510_myositis0.81953550
105MP0005390_skeleton_phenotype0.81590698
106MP0009765_abnormal_xenobiotic_induced0.81237135
107MP0003186_abnormal_redox_activity0.81086104
108MP0000598_abnormal_liver_morphology0.80377626
109MP0000003_abnormal_adipose_tissue0.79366640
110MP0005584_abnormal_enzyme/coenzyme_acti0.78223216
111MP0002006_tumorigenesis0.77986865
112MP0002998_abnormal_bone_remodeling0.77503030
113MP0002019_abnormal_tumor_incidence0.77322482
114MP0005319_abnormal_enzyme/_coenzyme0.77005298
115MP0002970_abnormal_white_adipose0.76854370
116MP0009643_abnormal_urine_homeostasis0.75151458
117MP0009763_increased_sensitivity_to0.74886468
118MP0008873_increased_physiological_sensi0.74366318
119MP0009278_abnormal_bone_marrow0.73874636
120MP0005381_digestive/alimentary_phenotyp0.73616601
121MP0008874_decreased_physiological_sensi0.72977655
122MP0000371_diluted_coat_color0.72477972
123MP0000604_amyloidosis0.72182102
124MP0006035_abnormal_mitochondrial_morpho0.71097398
125MP0005164_abnormal_response_to0.71080275
126MP0001851_eye_inflammation0.69840005
127MP0002118_abnormal_lipid_homeostasis0.65822078

Predicted human phenotypes

RankGene SetZ-score
1Recurrent abscess formation (HP:0002722)4.45823949
2Petechiae (HP:0000967)4.18969118
3Recurrent bacterial skin infections (HP:0005406)4.17576500
4Thrombocytosis (HP:0001894)4.16924130
5IgM deficiency (HP:0002850)4.06219514
6Vacuolated lymphocytes (HP:0001922)3.80521739
7Aplastic anemia (HP:0001915)3.78449384
8Increased neuronal autofluorescent lipopigment (HP:0002074)3.55203235
9Elevated erythrocyte sedimentation rate (HP:0003565)3.44404015
10Myositis (HP:0100614)3.42799863
11Pustule (HP:0200039)3.36364306
12Reduced antithrombin III activity (HP:0001976)3.31965535
13Abnormal number of erythroid precursors (HP:0012131)3.23740742
14Increased cerebral lipofuscin (HP:0011813)3.22142219
15Chronic otitis media (HP:0000389)3.14513606
16Agnosia (HP:0010524)3.12840978
17Dysostosis multiplex (HP:0000943)2.99924037
18Increased serum ferritin (HP:0003281)2.97436649
19Abnormality of cells of the erythroid lineage (HP:0012130)2.96202386
20Abnormal isoelectric focusing of serum transferrin (HP:0003160)2.93949730
21Abnormal protein N-linked glycosylation (HP:0012347)2.93949730
22Abnormal protein glycosylation (HP:0012346)2.93949730
23Abnormal glycosylation (HP:0012345)2.93949730
24Type I transferrin isoform profile (HP:0003642)2.91468373
25Hypertensive crisis (HP:0100735)2.84722322
26Hemorrhage of the eye (HP:0011885)2.84232783
27Abnormality of T cell physiology (HP:0011840)2.83522161
28Amyloidosis (HP:0011034)2.79262394
29Abnormality of glycolipid metabolism (HP:0010969)2.76570897
30Abnormality of liposaccharide metabolism (HP:0010968)2.76570897
31Abnormality of glycosphingolipid metabolism (HP:0004343)2.76570897
32Abnormality of macrophages (HP:0004311)2.76095051
33Eczematoid dermatitis (HP:0000976)2.72328642
34Chronic obstructive pulmonary disease (HP:0006510)2.71827884
35Obstructive lung disease (HP:0006536)2.71827884
36Deep venous thrombosis (HP:0002625)2.71725403
37Epistaxis (HP:0000421)2.66451399
38Decreased activity of mitochondrial respiratory chain (HP:0008972)2.65983767
39Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.65983767
40Gastrointestinal infarctions (HP:0005244)2.64911350
41Meningitis (HP:0001287)2.63376285
42Abnormal delayed hypersensitivity skin test (HP:0002963)2.62250989
43Recurrent cutaneous fungal infections (HP:0011370)2.61781798
44Chronic mucocutaneous candidiasis (HP:0002728)2.61781798
45Recurrent skin infections (HP:0001581)2.60537367
46Gastrointestinal inflammation (HP:0004386)2.57730547
47Thoracic kyphosis (HP:0002942)2.56096454
48Prolonged bleeding time (HP:0003010)2.53797775
49Mucopolysacchariduria (HP:0008155)2.51764631
50Urinary glycosaminoglycan excretion (HP:0003541)2.51764631
51Vertebral compression fractures (HP:0002953)2.51330422
52Abnormality of polysaccharide metabolism (HP:0011012)2.40076924
53Abnormality of glycosaminoglycan metabolism (HP:0004371)2.40076924
54Abnormality of mucopolysaccharide metabolism (HP:0011020)2.40076924
55Increased IgE level (HP:0003212)2.39873588
56Polygenic inheritance (HP:0010982)2.39647143
57Seborrheic dermatitis (HP:0001051)2.39006279
58Mediastinal lymphadenopathy (HP:0100721)2.38838923
59Inflammation of the large intestine (HP:0002037)2.38231093
60Abnormality of iron homeostasis (HP:0011031)2.37873658
61Reticulocytopenia (HP:0001896)2.33590832
62Recurrent viral infections (HP:0004429)2.32845758
63Increased IgM level (HP:0003496)2.31523077
64Stomatitis (HP:0010280)2.29051253
65Microretrognathia (HP:0000308)2.26715260
66Abnormality of the heme biosynthetic pathway (HP:0010472)2.26309439
67Impaired platelet aggregation (HP:0003540)2.26124867
68Abnormal platelet function (HP:0011869)2.26124867
69Purpura (HP:0000979)2.26023142
70Generalized aminoaciduria (HP:0002909)2.23274590
71Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)2.20562975
72Periodontitis (HP:0000704)2.20182935
73Recurrent fungal infections (HP:0002841)2.19765126
74Recurrent bronchitis (HP:0002837)2.19448755
75Interstitial pulmonary disease (HP:0006530)2.18361036
76Abnormality of the thoracic spine (HP:0100711)2.17473370
77Neutropenia (HP:0001875)2.16964995
78Lymphopenia (HP:0001888)2.16613924
79Encephalitis (HP:0002383)2.16168023
80Abnormality of the prostate (HP:0008775)2.16030757
81Recurrent gram-negative bacterial infections (HP:0005420)2.15994892
82Poor head control (HP:0002421)2.15222948
83Panhypogammaglobulinemia (HP:0003139)2.13409696
84Cholecystitis (HP:0001082)2.10859635
85Abnormal gallbladder physiology (HP:0012438)2.10859635
86Albinism (HP:0001022)2.09796477
87Progressive neurologic deterioration (HP:0002344)2.09371001
88Abnormality of B cell number (HP:0010975)2.08864204
89B lymphocytopenia (HP:0010976)2.08864204
90Agammaglobulinemia (HP:0004432)2.07484105
91Abnormal enzyme/coenzyme activity (HP:0012379)2.03689753
92Granulocytopenia (HP:0001913)2.02892206
93Abnormality of cells of the lymphoid lineage (HP:0012140)2.02777374
94Colitis (HP:0002583)2.01640433
95Joint stiffness (HP:0001387)2.00834830
96Xanthomatosis (HP:0000991)2.00191713
97Pancytopenia (HP:0001876)1.99752311
98Abnormality of alkaline phosphatase activity (HP:0004379)1.99595141
99Prolonged neonatal jaundice (HP:0006579)1.98782437
100Vasculitis (HP:0002633)1.98500189
101Villous atrophy (HP:0011473)1.98376918
102Abnormality of small intestinal villus morphology (HP:0011472)1.98376918
103Papilloma (HP:0012740)1.97152741
104Verrucae (HP:0200043)1.97152741
105Gingivitis (HP:0000230)1.97031318
106Abnormality of transition element cation homeostasis (HP:0011030)1.96719082
107Elevated alkaline phosphatase (HP:0003155)1.95965645
108Ragged-red muscle fibers (HP:0003200)1.95708322
109Abnormality of long-chain fatty-acid metabolism (HP:0010964)1.95643079
110J-shaped sella turcica (HP:0002680)1.95056078
111Fatigue (HP:0012378)1.94094741
112Poikiloderma (HP:0001029)1.92800131
113Cellulitis (HP:0100658)1.90994331
114Abnormality of T cells (HP:0002843)1.90979238
115Abnormality of the intrinsic pathway (HP:0010989)1.90102725
116Rough bone trabeculation (HP:0100670)1.89670249
117Broad face (HP:0000283)1.88561853
118Hypokinesia (HP:0002375)1.88434345
119Viral hepatitis (HP:0006562)1.87954618
120Hepatosplenomegaly (HP:0001433)1.87933920
121Pallor (HP:0000980)1.87327499
122Chronic diarrhea (HP:0002028)1.87299067
123Stridor (HP:0010307)1.86771867
124Beaking of vertebral bodies (HP:0004568)1.86208190
125Hypergammaglobulinemia (HP:0010702)1.85886488
126Hepatic necrosis (HP:0002605)1.85741905
127Hypertriglyceridemia (HP:0002155)1.84215240
128Limb hypertonia (HP:0002509)1.82212240
129Severe visual impairment (HP:0001141)1.81264169
130Nasal polyposis (HP:0100582)1.81235832
131Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)1.80570350
132Gastrointestinal stroma tumor (HP:0100723)1.80315817
133Chest pain (HP:0100749)1.80296047
134Menorrhagia (HP:0000132)1.79293052
135Systemic lupus erythematosus (HP:0002725)1.78303507
136Pulmonary infiltrates (HP:0002113)1.77778498
137Gingival bleeding (HP:0000225)1.76776780
138Orchitis (HP:0100796)1.76457976
139Urticaria (HP:0001025)1.76397439
140Entropion (HP:0000621)1.75267946
141Reticulocytosis (HP:0001923)1.74410416
142Hepatitis (HP:0012115)1.71769503
143Loss of speech (HP:0002371)1.67931854

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAP4K13.71562567
2SMG13.52716055
3STK163.27770901
4BCKDK3.00550902
5KIT2.96806525
6MAP2K32.96028336
7FLT32.76060409
8ERN12.74305978
9VRK22.59088807
10BLK2.50570835
11MAP3K122.36502006
12ZAP702.24725769
13PRPF4B2.24209212
14IRAK42.23883732
15MAP3K62.19107678
16BTK2.12797715
17CSF1R2.10040671
18NME22.08895805
19SIK12.07205687
20TAOK32.01154643
21EIF2AK32.00721284
22EEF2K1.89884406
23PIM21.87872282
24RIPK41.85266812
25FES1.81057035
26SYK1.69881789
27CAMKK21.61406974
28SCYL21.60812026
29TEC1.60433655
30TXK1.53940266
31MATK1.52134198
32EPHA21.47242421
33TBK11.46065889
34GRK61.44942182
35MAP3K111.44215947
36PKN21.40378682
37FGFR41.39657844
38MAP3K31.31645104
39TYK21.27334780
40BUB11.26578947
41SIK31.24937833
42VRK11.23430573
43TAOK21.21748973
44CLK11.20369865
45ICK1.19999232
46MAP2K61.15735102
47ADRBK21.12883302
48TRIB31.09298324
49CDK81.08313761
50PAK41.07872065
51MAP3K141.07533888
52TESK11.06847781
53LYN1.06196032
54BRSK21.01353003
55PRKD20.96585348
56TNK20.96032608
57LRRK20.95459921
58PTK60.94414460
59STK100.92409892
60CDK120.91608131
61DAPK10.90767579
62CCNB10.90431958
63MAP3K130.88361263
64MAPKAPK50.88300112
65MAPKAPK30.85655716
66JAK30.84410992
67MARK20.84203983
68TAF10.83085105
69TNIK0.79296923
70LMTK20.79034935
71MAP3K70.78234131
72CDK190.76693658
73PDPK10.75942515
74EIF2AK10.75613031
75PASK0.74870740
76HCK0.74861410
77LCK0.74168930
78RPS6KB20.71948599
79CDC42BPA0.71871005
80PDK10.68059898
81MELK0.65895314
82RAF10.62922608
83NME10.62776204
84TESK20.61366673
85MAPK40.61300813
86DYRK1B0.59866192
87BRSK10.59429723
88MAP3K10.59035979
89IKBKB0.58564685
90IRAK30.57929965
91MST1R0.57286745
92BMX0.56866020
93IKBKE0.56778300
94MAP3K50.56193748
95EPHB10.55987680
96MAP2K40.55504794
97FGR0.54879547
98CAMKK10.54641048
99CHUK0.53446948
100PIM10.53238785
101KDR0.51865647
102CDK90.51174779
103ITK0.50376805
104MTOR0.50191202
105MAPKAPK20.49439688
106MAPK120.49004135
107MAP3K100.47323572
108RPS6KA60.45512430
109MAP3K80.45119322
110TSSK60.43798989
111MARK30.43112192
112ARAF0.41935632
113PRKCD0.41826572
114TLK10.41030154
115MYLK0.40295558
116PRKG20.39545223
117BRAF0.39092029
118TAOK10.38918036
119RPS6KA20.38074250
120MAPK110.37892452
121CDK70.37521763
122CDK40.37485509
123CSK0.37439758
124MAP2K20.37024474
125STK380.36908719
126IRAK20.36077335
127WEE10.36072907
128JAK10.36031874
129ATR0.34541406
130TGFBR20.33540431
131PIK3CG0.33253050
132RPS6KL10.32859874
133RPS6KC10.32859874
134ILK0.31106621
135INSRR0.29516111
136TGFBR10.27442981
137HIPK20.26619989
138SIK20.26526966

Predicted pathways (KEGG)

RankGene SetZ-score
1DNA replication_Homo sapiens_hsa030303.17579422
2Protein export_Homo sapiens_hsa030603.12212368
3Other glycan degradation_Homo sapiens_hsa005112.97350260
4Mismatch repair_Homo sapiens_hsa034302.62058816
5Base excision repair_Homo sapiens_hsa034102.52950533
6Cyanoamino acid metabolism_Homo sapiens_hsa004602.47641181
7Ribosome_Homo sapiens_hsa030102.40472325
8Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006042.34179325
9N-Glycan biosynthesis_Homo sapiens_hsa005102.32667671
10Folate biosynthesis_Homo sapiens_hsa007902.20480252
11Fat digestion and absorption_Homo sapiens_hsa049752.08291109
12Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.90551051
13Glycosaminoglycan degradation_Homo sapiens_hsa005311.89705385
14Pentose phosphate pathway_Homo sapiens_hsa000301.79167682
15Allograft rejection_Homo sapiens_hsa053301.73833991
16Lysosome_Homo sapiens_hsa041421.73386400
17Galactose metabolism_Homo sapiens_hsa000521.70997372
18Renin-angiotensin system_Homo sapiens_hsa046141.66939941
19Pancreatic secretion_Homo sapiens_hsa049721.65850514
20Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.61314934
21Pyrimidine metabolism_Homo sapiens_hsa002401.59623384
22Leishmaniasis_Homo sapiens_hsa051401.58633511
23Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.52580207
24Primary immunodeficiency_Homo sapiens_hsa053401.50699841
25Autoimmune thyroid disease_Homo sapiens_hsa053201.48180262
26Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.42531034
27Drug metabolism - other enzymes_Homo sapiens_hsa009831.42294624
28Legionellosis_Homo sapiens_hsa051341.40988570
29Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.40247599
30Proteasome_Homo sapiens_hsa030501.39692632
31Graft-versus-host disease_Homo sapiens_hsa053321.39336229
32Homologous recombination_Homo sapiens_hsa034401.35678601
33Non-small cell lung cancer_Homo sapiens_hsa052231.35241799
34Vitamin digestion and absorption_Homo sapiens_hsa049771.32469043
35Hepatitis C_Homo sapiens_hsa051601.29633936
36B cell receptor signaling pathway_Homo sapiens_hsa046621.29056147
37Fructose and mannose metabolism_Homo sapiens_hsa000511.26633742
38Biosynthesis of amino acids_Homo sapiens_hsa012301.25620833
39Notch signaling pathway_Homo sapiens_hsa043301.25604344
40Nucleotide excision repair_Homo sapiens_hsa034201.24225121
41Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.22456953
42Other types of O-glycan biosynthesis_Homo sapiens_hsa005141.20625782
43Pancreatic cancer_Homo sapiens_hsa052121.19420677
44SNARE interactions in vesicular transport_Homo sapiens_hsa041301.15106806
45Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.14789408
46Maturity onset diabetes of the young_Homo sapiens_hsa049501.12181509
47Chronic myeloid leukemia_Homo sapiens_hsa052201.11421595
48Caffeine metabolism_Homo sapiens_hsa002321.10775532
49Starch and sucrose metabolism_Homo sapiens_hsa005001.09813468
50T cell receptor signaling pathway_Homo sapiens_hsa046601.09023726
51Antigen processing and presentation_Homo sapiens_hsa046121.06849693
52Toxoplasmosis_Homo sapiens_hsa051451.06386947
53Shigellosis_Homo sapiens_hsa051311.05506343
54Hepatitis B_Homo sapiens_hsa051611.04843484
55One carbon pool by folate_Homo sapiens_hsa006701.03218481
562-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.03134594
57Hematopoietic cell lineage_Homo sapiens_hsa046401.02877466
58Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.01549419
59RNA polymerase_Homo sapiens_hsa030201.00881687
60Bladder cancer_Homo sapiens_hsa052191.00761732
61RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.99602180
62Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.94889329
63Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.94612964
64TNF signaling pathway_Homo sapiens_hsa046680.90982936
65Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.89768843
66Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.88181158
67Selenocompound metabolism_Homo sapiens_hsa004500.87461734
68Type I diabetes mellitus_Homo sapiens_hsa049400.85587205
69Sulfur relay system_Homo sapiens_hsa041220.85058476
70Epstein-Barr virus infection_Homo sapiens_hsa051690.84870530
71Carbohydrate digestion and absorption_Homo sapiens_hsa049730.84226042
72Asthma_Homo sapiens_hsa053100.83741765
73Viral myocarditis_Homo sapiens_hsa054160.80469963
74VEGF signaling pathway_Homo sapiens_hsa043700.79732779
75Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.79587839
76Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.78235325
77Influenza A_Homo sapiens_hsa051640.77940760
78Tuberculosis_Homo sapiens_hsa051520.77872750
79Toll-like receptor signaling pathway_Homo sapiens_hsa046200.75920499
80Glycerophospholipid metabolism_Homo sapiens_hsa005640.75165270
81Protein digestion and absorption_Homo sapiens_hsa049740.74802929
82Pertussis_Homo sapiens_hsa051330.74746456
83Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.74210869
84Leukocyte transendothelial migration_Homo sapiens_hsa046700.72443843
85Osteoclast differentiation_Homo sapiens_hsa043800.71019413
86Pentose and glucuronate interconversions_Homo sapiens_hsa000400.68428244
87Spliceosome_Homo sapiens_hsa030400.66964590
88Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.66383770
89Intestinal immune network for IgA production_Homo sapiens_hsa046720.66286609
90Platelet activation_Homo sapiens_hsa046110.65796152
91Central carbon metabolism in cancer_Homo sapiens_hsa052300.65280343
92Measles_Homo sapiens_hsa051620.64963351
93Complement and coagulation cascades_Homo sapiens_hsa046100.64557448
94Purine metabolism_Homo sapiens_hsa002300.63888313
95Carbon metabolism_Homo sapiens_hsa012000.63831819
96Viral carcinogenesis_Homo sapiens_hsa052030.63509870
97Jak-STAT signaling pathway_Homo sapiens_hsa046300.62641066
98HTLV-I infection_Homo sapiens_hsa051660.62051136
99Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.61428406
100Glutathione metabolism_Homo sapiens_hsa004800.61330206
101Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.61236648
102Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.58681971
103Peroxisome_Homo sapiens_hsa041460.58468324
104Glycerolipid metabolism_Homo sapiens_hsa005610.57771981
105Arginine and proline metabolism_Homo sapiens_hsa003300.56870856
106Adipocytokine signaling pathway_Homo sapiens_hsa049200.56857290
107Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.56119493
108Herpes simplex infection_Homo sapiens_hsa051680.55625769
109Metabolic pathways_Homo sapiens_hsa011000.53962591
110Staphylococcus aureus infection_Homo sapiens_hsa051500.53653384
111Endocytosis_Homo sapiens_hsa041440.52184222
112Fatty acid elongation_Homo sapiens_hsa000620.51460940
113Cysteine and methionine metabolism_Homo sapiens_hsa002700.50123761
114Phagosome_Homo sapiens_hsa041450.49076913
115Acute myeloid leukemia_Homo sapiens_hsa052210.48894585
116African trypanosomiasis_Homo sapiens_hsa051430.48753731
117ABC transporters_Homo sapiens_hsa020100.48589131
118Arachidonic acid metabolism_Homo sapiens_hsa005900.48031355
119Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.46055944
120Neurotrophin signaling pathway_Homo sapiens_hsa047220.46020948
121Vibrio cholerae infection_Homo sapiens_hsa051100.45994168
122Insulin resistance_Homo sapiens_hsa049310.45762556
123Fanconi anemia pathway_Homo sapiens_hsa034600.44899682
124Primary bile acid biosynthesis_Homo sapiens_hsa001200.43444973
125Malaria_Homo sapiens_hsa051440.43426722
126mTOR signaling pathway_Homo sapiens_hsa041500.43321144
127Chemokine signaling pathway_Homo sapiens_hsa040620.43177204
128Sulfur metabolism_Homo sapiens_hsa009200.42523096
129Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.42420635
130Non-homologous end-joining_Homo sapiens_hsa034500.41797683
131Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.41251697
132Endometrial cancer_Homo sapiens_hsa052130.39667174
133NOD-like receptor signaling pathway_Homo sapiens_hsa046210.39576879
134Histidine metabolism_Homo sapiens_hsa003400.39543356
135Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.38135003
136NF-kappa B signaling pathway_Homo sapiens_hsa040640.37633543
137Apoptosis_Homo sapiens_hsa042100.36747466
138Small cell lung cancer_Homo sapiens_hsa052220.35945261
139Choline metabolism in cancer_Homo sapiens_hsa052310.35875473

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