SLC35D2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: Nucleotide sugars, which are synthesized in the cytosol or the nucleus, are high-energy donor substrates for glycosyltransferases located in the lumen of the endoplasmic reticulum and Golgi apparatus. Translocation of nucleotide sugars from the cytosol into the lumen compartment is mediated by specific nucleotide sugar transporters, such as SLC35D2 (Suda et al., 2004 [PubMed 15082721]). NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)7.15455054
2L-phenylalanine catabolic process (GO:0006559)7.15455054
3L-phenylalanine metabolic process (GO:0006558)6.77015631
4erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)6.77015631
5aromatic amino acid family catabolic process (GO:0009074)6.64377117
6indole-containing compound catabolic process (GO:0042436)6.19868644
7indolalkylamine catabolic process (GO:0046218)6.19868644
8tryptophan catabolic process (GO:0006569)6.19868644
9tryptophan metabolic process (GO:0006568)5.84437883
10triglyceride-rich lipoprotein particle remodeling (GO:0034370)5.82751728
11kynurenine metabolic process (GO:0070189)5.70791853
12bile acid biosynthetic process (GO:0006699)5.63211221
13glyoxylate metabolic process (GO:0046487)5.55991011
14cellular glucuronidation (GO:0052695)5.28352321
15high-density lipoprotein particle remodeling (GO:0034375)5.26054973
16negative regulation of fibrinolysis (GO:0051918)5.19874063
17urea metabolic process (GO:0019627)5.19414464
18urea cycle (GO:0000050)5.19414464
19regulation of fibrinolysis (GO:0051917)5.15196207
20complement activation, alternative pathway (GO:0006957)5.14603860
21regulation of protein activation cascade (GO:2000257)5.09290077
22cellular biogenic amine catabolic process (GO:0042402)5.07070876
23amine catabolic process (GO:0009310)5.07070876
24alpha-linolenic acid metabolic process (GO:0036109)5.05702423
25maturation of 5.8S rRNA (GO:0000460)5.05349264
26protein carboxylation (GO:0018214)5.04721996
27peptidyl-glutamic acid carboxylation (GO:0017187)5.04721996
28cysteine metabolic process (GO:0006534)5.00879438
29negative regulation of protein oligomerization (GO:0032460)4.95477213
30fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)4.86812910
31glucuronate metabolic process (GO:0019585)4.86432209
32uronic acid metabolic process (GO:0006063)4.86432209
33sulfur amino acid catabolic process (GO:0000098)4.86105614
34T-helper 1 type immune response (GO:0042088)4.85337883
35serine family amino acid catabolic process (GO:0009071)4.82619029
36bile acid metabolic process (GO:0008206)4.81139085
37aromatic amino acid family metabolic process (GO:0009072)4.79709396
38nitrogen cycle metabolic process (GO:0071941)4.79096799
39regulation of complement activation (GO:0030449)4.75782438
40regulation of cholesterol esterification (GO:0010872)4.61821273
41reverse cholesterol transport (GO:0043691)4.57418321
42phospholipid efflux (GO:0033700)4.54711407
43homocysteine metabolic process (GO:0050667)4.53409202
44tyrosine metabolic process (GO:0006570)4.50540842
45regulation of triglyceride catabolic process (GO:0010896)4.48388419
46aldehyde catabolic process (GO:0046185)4.47721005
47protein-lipid complex remodeling (GO:0034368)4.47320235
48macromolecular complex remodeling (GO:0034367)4.47320235
49plasma lipoprotein particle remodeling (GO:0034369)4.47320235
50indolalkylamine metabolic process (GO:0006586)4.41058951
51amino-acid betaine metabolic process (GO:0006577)4.38779871
52protein-lipid complex assembly (GO:0065005)4.35398921
53acylglycerol homeostasis (GO:0055090)4.35347563
54triglyceride homeostasis (GO:0070328)4.35347563
55bile acid and bile salt transport (GO:0015721)4.32443349
56alpha-amino acid catabolic process (GO:1901606)4.31728275
57imidazole-containing compound metabolic process (GO:0052803)4.26710960
58negative regulation of sterol transport (GO:0032372)4.24995304
59negative regulation of cholesterol transport (GO:0032375)4.24995304
60regulation of systemic arterial blood pressure by renin-angiotensin (GO:0003081)4.23535537
61glycine metabolic process (GO:0006544)4.14891438
62thrombin receptor signaling pathway (GO:0070493)4.09890641
63cholesterol efflux (GO:0033344)4.06901893
64coenzyme catabolic process (GO:0009109)4.05670445
65plasma lipoprotein particle clearance (GO:0034381)4.03692533
66NAD biosynthetic process (GO:0009435)4.01693082
67regulation of cholesterol homeostasis (GO:2000188)3.98846829
68benzene-containing compound metabolic process (GO:0042537)3.97638561
69fibrinolysis (GO:0042730)3.97290633
70regulation of protein homooligomerization (GO:0032462)3.96180782
71cellular amino acid catabolic process (GO:0009063)3.94429862
72serine family amino acid metabolic process (GO:0009069)3.94197544
73protein import into peroxisome matrix (GO:0016558)3.92398381
74blood coagulation, intrinsic pathway (GO:0007597)3.91196201
75lysine metabolic process (GO:0006553)3.90162323
76lysine catabolic process (GO:0006554)3.90162323
77ethanol oxidation (GO:0006069)3.89349936
78protein-lipid complex subunit organization (GO:0071825)3.89063377
79regulation of extracellular matrix disassembly (GO:0010715)3.87827724
80low-density lipoprotein particle remodeling (GO:0034374)3.87557360
81very-low-density lipoprotein particle assembly (GO:0034379)3.87346882
82arginine metabolic process (GO:0006525)3.87271233
83plasma lipoprotein particle assembly (GO:0034377)3.85699342
84pyridine nucleotide biosynthetic process (GO:0019363)3.79305738
85nicotinamide nucleotide biosynthetic process (GO:0019359)3.79305738
86cellular ketone body metabolic process (GO:0046950)3.75462726
87glutamate metabolic process (GO:0006536)3.74539364
88intestinal absorption (GO:0050892)3.73749782
89serine family amino acid biosynthetic process (GO:0009070)3.72686291
90complement activation, classical pathway (GO:0006958)3.72228742
91positive regulation of triglyceride lipase activity (GO:0061365)3.71371902
92positive regulation of lipoprotein lipase activity (GO:0051006)3.71371902
93protein activation cascade (GO:0072376)3.71000271
94drug catabolic process (GO:0042737)3.67198582
95complement activation (GO:0006956)3.65990346
96cofactor catabolic process (GO:0051187)3.64002472
97cellular modified amino acid catabolic process (GO:0042219)3.63305843
98response to nitrosative stress (GO:0051409)3.62889850
99phospholipid homeostasis (GO:0055091)3.56052456
100regulation of bile acid biosynthetic process (GO:0070857)3.53299245
101negative regulation of lipase activity (GO:0060192)3.52760776
102urate metabolic process (GO:0046415)3.52201570
103drug transmembrane transport (GO:0006855)3.51852263
104cholesterol homeostasis (GO:0042632)3.49677938
105plasma lipoprotein particle organization (GO:0071827)3.49101971
106regulation of cholesterol biosynthetic process (GO:0045540)3.47691885
107cytolysis (GO:0019835)3.47598391
108organic acid catabolic process (GO:0016054)3.47526980
109carboxylic acid catabolic process (GO:0046395)3.47526980
110acute-phase response (GO:0006953)3.45437375
111dicarboxylic acid biosynthetic process (GO:0043650)3.44991997
112sterol homeostasis (GO:0055092)3.42805501
113negative regulation of glycogen biosynthetic process (GO:0045719)3.40346416
114positive regulation of extracellular matrix organization (GO:1903055)3.40274727
115regulation of cholesterol metabolic process (GO:0090181)3.38731024
116angiotensin maturation (GO:0002003)3.38271454
117antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G3.36947428
118epoxygenase P450 pathway (GO:0019373)3.35640508
119intestinal cholesterol absorption (GO:0030299)3.30337122
120lipopolysaccharide biosynthetic process (GO:0009103)3.28301630
121negative regulation of blood coagulation (GO:0030195)3.22160955
122negative regulation of hemostasis (GO:1900047)3.22160955
123lipoprotein metabolic process (GO:0042157)3.17856448
124glycosphingolipid catabolic process (GO:0046479)3.14710549
125lipoprotein transport (GO:0042953)3.14385256
126regulation of apoptotic cell clearance (GO:2000425)3.11527087
127fat-soluble vitamin biosynthetic process (GO:0042362)3.09824520
128regulation of extracellular matrix organization (GO:1903053)3.07000436
129lipopolysaccharide metabolic process (GO:0008653)3.03985311
130positive regulation of blood coagulation (GO:0030194)3.03723187
131positive regulation of hemostasis (GO:1900048)3.03723187
132antigen processing and presentation via MHC class Ib (GO:0002475)3.01487368
133negative regulation of coagulation (GO:0050819)3.01343739
134antigen processing and presentation of endogenous peptide antigen (GO:0002483)3.00001968
135glycolipid catabolic process (GO:0019377)2.95755017
136cholesterol transport (GO:0030301)2.90875509
137sterol transport (GO:0015918)2.90875509
138exogenous drug catabolic process (GO:0042738)2.90598428
139positive regulation of coagulation (GO:0050820)2.86912576
140negative regulation of wound healing (GO:0061045)2.78290261
141positive regulation of steroid metabolic process (GO:0045940)2.73722438
142diacylglycerol metabolic process (GO:0046339)2.72349906
143regulation of plasminogen activation (GO:0010755)2.70746107
144antigen processing and presentation of endogenous antigen (GO:0019883)2.67887743
145positive regulation of myeloid leukocyte mediated immunity (GO:0002888)2.65821884
146positive regulation of heterotypic cell-cell adhesion (GO:0034116)2.62809500
147positive regulation of isotype switching (GO:0045830)2.60458412
148negative regulation of glycogen metabolic process (GO:0070874)2.59155396
149cellular zinc ion homeostasis (GO:0006882)2.58656730
150hormone catabolic process (GO:0042447)2.56713741
151mannose metabolic process (GO:0006013)2.53966036
152positive regulation of fatty acid biosynthetic process (GO:0045723)2.53837785

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1* RXR_22158963_ChIP-Seq_LIVER_Mouse7.76995187
2EGR1_23403033_ChIP-Seq_LIVER_Mouse7.25961917
3* PPARA_22158963_ChIP-Seq_LIVER_Mouse6.72192533
4* LXR_22158963_ChIP-Seq_LIVER_Mouse6.00282298
5CEBPA_23403033_ChIP-Seq_LIVER_Mouse5.20680595
6FOXO1_23066095_ChIP-Seq_LIVER_Mouse4.72108670
7CEBPB_23403033_ChIP-Seq_LIVER_Mouse4.15983922
8TP63_17297297_ChIP-ChIP_HaCaT_Human4.08813236
9PPARG_19300518_ChIP-PET_3T3-L1_Mouse4.04367879
10NR1I2_20693526_ChIP-Seq_LIVER_Mouse3.44406302
11STAT6_21828071_ChIP-Seq_BEAS2B_Human3.09516400
12IRF8_22096565_ChIP-ChIP_GC-B_Human2.80522150
13TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.28549834
14IRF1_21803131_ChIP-Seq_MONOCYTES_Human2.10736867
15HNF4A_19761587_ChIP-ChIP_CACO-2_Human2.06036967
16ESR1_17901129_ChIP-ChIP_LIVER_Mouse11.0790027
17TCF7L2_21901280_ChIP-Seq_H4IIE_Rat1.86273749
18STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.85759666
19TRIM28_21343339_ChIP-Seq_HEK293_Human1.81516171
20CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.70532961
21FOXO3_23340844_ChIP-Seq_DLD1_Human1.69657115
22CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.67119434
23HTT_18923047_ChIP-ChIP_STHdh_Human1.64339543
24TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.54316548
25NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.54244430
26LXR_22292898_ChIP-Seq_THP-1_Human1.51085280
27TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.49647897
28* GATA6_25053715_ChIP-Seq_YYC3_Human1.48267729
29TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.47999111
30ELF1_17652178_ChIP-ChIP_JURKAT_Human1.42634774
31GATA1_19941826_ChIP-Seq_K562_Human1.41482285
32Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.39134051
33KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.37703457
34EGR1_19374776_ChIP-ChIP_THP-1_Human1.36593167
35ELK3_25401928_ChIP-Seq_HUVEC_Human1.34886016
36GATA2_19941826_ChIP-Seq_K562_Human1.28031280
37RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.27477219
38P63_26484246_Chip-Seq_KERATINOCYTES_Human1.26033930
39* HNF4A_19822575_ChIP-Seq_HepG2_Human1.25333548
40TCF4_18268006_ChIP-ChIP_LS174T_Human1.22652408
41MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.21190127
42PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.21113945
43IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.19048077
44FOXA2_19822575_ChIP-Seq_HepG2_Human1.19012621
45KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.16965986
46GATA1_22383799_ChIP-Seq_G1ME_Mouse1.15760875
47SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.14768247
48SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.12541452
49ZNF263_19887448_ChIP-Seq_K562_Human1.12109338
50IRF8_21731497_ChIP-ChIP_J774_Mouse1.10577493
51TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.09395949
52SPI1_23127762_ChIP-Seq_K562_Human1.09263653
53STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.08537628
54GATA1_22025678_ChIP-Seq_K562_Human1.06253520
55HIF1A_21447827_ChIP-Seq_MCF-7_Human1.04925610
56RACK7_27058665_Chip-Seq_MCF-7_Human1.04317146
57SCL_19346495_ChIP-Seq_HPC-7_Human1.04130965
58KAP1_22055183_ChIP-Seq_ESCs_Mouse1.02804197
59RXRA_24833708_ChIP-Seq_LIVER_Mouse1.02061541
60NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.00867873
61SRY_22984422_ChIP-ChIP_TESTIS_Rat0.99205934
62CLOCK_20551151_ChIP-Seq_293T_Human0.98879348
63STAT3_20064451_ChIP-Seq_CD4+T_Mouse0.98712614
64SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse0.97076621
65BP1_19119308_ChIP-ChIP_Hs578T_Human0.96953401
66TDRD3_21172665_ChIP-Seq_MCF-7_Human0.96944269
67TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.96544396
68* GATA4_25053715_ChIP-Seq_YYC3_Human0.96342929
69VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human0.95181696
70SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.94940588
71IRF8_27001747_Chip-Seq_BMDM_Mouse0.94100697
72IRF1_19129219_ChIP-ChIP_H3396_Human0.92816986
73* PRDM5_23873026_ChIP-Seq_MEFs_Mouse0.91450633
74SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse0.91288505
75PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.90680199
76ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human0.90281841
77JARID1B-DAIN_22020125_ChIP-Seq_ESCs_Mouse0.88365501
78SMAD4_19686287_ChIP-ChIP_HaCaT_Human0.88267678
79BCOR_27268052_Chip-Seq_Bcells_Human0.87681029
80POU5F1_18700969_ChIP-ChIP_MESCs_Mouse0.86368495
81NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse0.85905689
82ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.85773366
83VDR_24763502_ChIP-Seq_THP-1_Human0.84874723
84BCL6_27268052_Chip-Seq_Bcells_Human0.83912485
85* SOX2_27498859_Chip-Seq_STOMACH_Mouse0.83430587
86JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.83195641
87PPARD_23208498_ChIP-Seq_MDA-MB-231_Human0.83079367
88FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse0.82839625
89RARG_19884340_ChIP-ChIP_MEFs_Mouse0.82012260
90CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.80336000
91CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.75429776
92ESR1_21235772_ChIP-Seq_MCF-7_Human0.74793591
93STAT1_17558387_ChIP-Seq_HELA_Human0.74547642
94THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse0.71582629
95EGR1_19032775_ChIP-ChIP_M12_Human0.71075396
96* BMI1_19503595_ChIP-Seq_MEFsC_Mouse0.70440044
97GATA2_20887958_ChIP-Seq_HPC-7_Mouse0.68787120
98FOXP3_17237761_ChIP-ChIP_TREG_Mouse0.68255519
99NRF2_20460467_ChIP-Seq_MEFs_Mouse0.67925202
100NFE2L2_20460467_ChIP-Seq_MEFs_Mouse0.67925202
101RUNX1_20887958_ChIP-Seq_HPC-7_Mouse0.67646956
102SOX2_20726797_ChIP-Seq_SW620_Human0.67628729
103CDX2_20551321_ChIP-Seq_CACO-2_Human0.66025546
104SALL4_18804426_ChIP-ChIP_XEN_Mouse0.65935666
105SREBP2_21459322_ChIP-Seq_LIVER_Mouse0.65104901
106BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse0.64751388
107AR_21915096_ChIP-Seq_LNCaP-1F5_Human0.64167418
108BRD4_27068464_Chip-Seq_AML-cells_Mouse0.63541840
109CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse0.62015775
110AR_20517297_ChIP-Seq_VCAP_Human0.61372350
111BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.60606156
112PPAR_26484153_Chip-Seq_NCI-H1993_Human0.59673132
113MYB_21317192_ChIP-Seq_ERMYB_Mouse0.58321040
114LYL1_20887958_ChIP-Seq_HPC-7_Mouse0.56024840
115FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human0.55648401
116CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse0.55276759
117GATA1_19941827_ChIP-Seq_MEL_Mouse0.55095712
118PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse0.53851125
119RARA_24833708_ChIP-Seq_LIVER_Mouse0.53838213
120SREBP1_19666523_ChIP-Seq_LIVER_Mouse0.53806093
121ESR2_21235772_ChIP-Seq_MCF-7_Human0.53625343
122LMO2_20887958_ChIP-Seq_HPC-7_Mouse0.53483954
123PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.52788552
124CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse0.52772570
125FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.52763948
126CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse0.52597932
127FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human0.52564984
128STAT4_19710469_ChIP-ChIP_TH1__Mouse0.52333529
129RARB_24833708_ChIP-Seq_LIVER_Mouse0.52213977
130PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse0.52057980
131ESR1_20079471_ChIP-ChIP_T-47D_Human0.51994001
132PPARG_20887899_ChIP-Seq_3T3-L1_Mouse0.51912149
133CEBPB_22108803_ChIP-Seq_LS180_Human0.51174524
134STAT3_1855785_ChIP-Seq_MESCs_Mouse0.51054046
135GATA2_21666600_ChIP-Seq_HMVEC_Human0.50806617
136* RAD21_21589869_ChIP-Seq_MESCs_Mouse0.49785579
137FOXA1_26743006_Chip-Seq_LNCaP-abl_Human0.49708671
138SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse0.48383386
139NFE2_27457419_Chip-Seq_LIVER_Mouse0.47656213
140FOXA1_25552417_ChIP-Seq_VCAP_Human0.47284181
141AUTS2_25519132_ChIP-Seq_293T-REX_Human0.47022697
142GATA2_22383799_ChIP-Seq_G1ME_Mouse0.46162520
143PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse0.44733901
144EZH2_27294783_Chip-Seq_NPCs_Mouse0.44480084
145GATA3_26560356_Chip-Seq_TH2_Human0.44311324
146NR0B1_18358816_ChIP-ChIP_MESCs_Mouse0.43991495

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002139_abnormal_hepatobiliary_system7.77341842
2MP0005360_urolithiasis7.02251670
3MP0005085_abnormal_gallbladder_physiolo6.10269124
4MP0005365_abnormal_bile_salt5.65487043
5MP0008875_abnormal_xenobiotic_pharmacok4.84471818
6MP0003806_abnormal_nucleotide_metabolis4.35065317
7MP0003252_abnormal_bile_duct3.57784731
8MP0010329_abnormal_lipoprotein_level3.20078060
9MP0003195_calcinosis2.96422456
10MP0003300_gastrointestinal_ulcer2.91712940
11MP0009840_abnormal_foam_cell2.68637915
12MP0005083_abnormal_biliary_tract2.68015686
13MP0001873_stomach_inflammation2.52947593
14MP0005332_abnormal_amino_acid2.50903653
15MP0001666_abnormal_nutrient_absorption2.42530581
16MP0003191_abnormal_cellular_cholesterol2.27287857
17MP0004019_abnormal_vitamin_homeostasis2.25626437
18MP0002138_abnormal_hepatobiliary_system2.16783820
19MP0000609_abnormal_liver_physiology2.06321752
20MP0003183_abnormal_peptide_metabolism2.00244736
21MP0005451_abnormal_body_composition1.86739911
22MP0002118_abnormal_lipid_homeostasis1.85733892
23MP0008004_abnormal_stomach_pH1.84974240
24MP0003186_abnormal_redox_activity1.73986936
25MP0003868_abnormal_feces_composition1.71358075
26MP0005319_abnormal_enzyme/_coenzyme1.70241116
27MP0000858_altered_metastatic_potential1.67394579
28MP0001764_abnormal_homeostasis1.63815249
29MP0009697_abnormal_copulation1.61345442
30MP0009333_abnormal_splenocyte_physiolog1.55360636
31MP0005023_abnormal_wound_healing1.52451160
32MP0001915_intracranial_hemorrhage1.51037800
33MP0004264_abnormal_extraembryonic_tissu1.48369685
34MP0001348_abnormal_lacrimal_gland1.47715826
35MP0010368_abnormal_lymphatic_system1.47388085
36MP0005584_abnormal_enzyme/coenzyme_acti1.46431518
37MP0009764_decreased_sensitivity_to1.43089397
38MP0003950_abnormal_plasma_membrane1.40171210
39MP0009643_abnormal_urine_homeostasis1.36288259
40MP0001663_abnormal_digestive_system1.34454063
41MP0003436_decreased_susceptibility_to1.30133523
42MP0003724_increased_susceptibility_to1.27623315
43MP0008469_abnormal_protein_level1.24088721
44MP0000598_abnormal_liver_morphology1.17768629
45MP0004272_abnormal_basement_membrane1.17534021
46MP0000465_gastrointestinal_hemorrhage1.16512817
47MP0001851_eye_inflammation1.14051227
48MP0009763_increased_sensitivity_to1.13831332
49MP0001346_abnormal_lacrimal_gland1.11983340
50MP0010234_abnormal_vibrissa_follicle1.10704644
51MP0002876_abnormal_thyroid_physiology1.08889742
52MP0006054_spinal_hemorrhage1.08053792
53MP0003303_peritoneal_inflammation1.07182440
54MP0003172_abnormal_lysosome_physiology1.06747591
55MP0000920_abnormal_myelination1.06189610
56MP0004782_abnormal_surfactant_physiolog1.05934580
57MP0005408_hypopigmentation1.02690025
58MP0004381_abnormal_hair_follicle1.02446201
59MP0005310_abnormal_salivary_gland1.02194747
60MP0005647_abnormal_sex_gland1.02147320
61MP0003566_abnormal_cell_adhesion1.01964130
62MP0003011_delayed_dark_adaptation1.01905931
63MP0005381_digestive/alimentary_phenotyp1.01593333
64MP0009785_altered_susceptibility_to1.00405738
65MP0003656_abnormal_erythrocyte_physiolo0.97651076
66MP0002089_abnormal_postnatal_growth/wei0.97603811
67MP0001853_heart_inflammation0.96726001
68MP0002998_abnormal_bone_remodeling0.96566603
69MP0001835_abnormal_antigen_presentation0.95736883
70MP0005636_abnormal_mineral_homeostasis0.95387445
71MP0009765_abnormal_xenobiotic_induced0.93636635
72MP0005464_abnormal_platelet_physiology0.91742789
73MP0003879_abnormal_hair_cell0.91468009
74MP0003866_abnormal_defecation0.90514046
75MP0005084_abnormal_gallbladder_morpholo0.89401317
76MP0002254_reproductive_system_inflammat0.88492250
77MP0009642_abnormal_blood_homeostasis0.87704384
78MP0006082_CNS_inflammation0.85939340
79MP0000477_abnormal_intestine_morphology0.84897569
80MP0005670_abnormal_white_adipose0.83642400
81MP0002405_respiratory_system_inflammati0.82461309
82MP0005220_abnormal_exocrine_pancreas0.82275143
83MP0002419_abnormal_innate_immunity0.81431992
84MP0005376_homeostasis/metabolism_phenot0.78389649
85MP0005025_abnormal_response_to0.76594593
86MP0003448_altered_tumor_morphology0.75617918
87MP0003453_abnormal_keratinocyte_physiol0.74779756
88MP0005167_abnormal_blood-brain_barrier0.73681131
89MP0001765_abnormal_ion_homeostasis0.73092689
90MP0001845_abnormal_inflammatory_respons0.71203019
91MP0003705_abnormal_hypodermis_morpholog0.70638439
92MP0005257_abnormal_intraocular_pressure0.69459085
93MP0004147_increased_porphyrin_level0.68561652
94MP0006036_abnormal_mitochondrial_physio0.67443326
95MP0005197_abnormal_uvea_morphology0.65501212
96MP0000685_abnormal_immune_system0.64593494
97MP0009379_abnormal_foot_pigmentation0.64115641
98MP0005409_darkened_coat_color0.63733781
99MP0005387_immune_system_phenotype0.63662387
100MP0001790_abnormal_immune_system0.63662387
101MP0005334_abnormal_fat_pad0.63246630
102MP0002078_abnormal_glucose_homeostasis0.62466995
103MP0005266_abnormal_metabolism0.62366949
104MP0005448_abnormal_energy_balance0.62143608
105MP0005595_abnormal_vascular_smooth0.61808171
106MP0003718_maternal_effect0.59592311
107MP0000490_abnormal_crypts_of0.59511772
108MP0002136_abnormal_kidney_physiology0.59467309
109MP0001800_abnormal_humoral_immune0.59201585
110MP0001756_abnormal_urination0.58381712
111MP0000604_amyloidosis0.56872412
112MP0003638_abnormal_response/metabolism_0.54168363
113MP0002132_abnormal_respiratory_system0.53651556
114MP0005166_decreased_susceptibility_to0.53520286
115MP0009053_abnormal_anal_canal0.52624619
116MP0002971_abnormal_brown_adipose0.51821776
117MP0004947_skin_inflammation0.51612496
118MP0010155_abnormal_intestine_physiology0.51101665
119MP0002148_abnormal_hypersensitivity_rea0.49902544
120MP0001533_abnormal_skeleton_physiology0.49023158
121MP0005395_other_phenotype0.49019237
122MP0003690_abnormal_glial_cell0.48400392
123MP0005535_abnormal_body_temperature0.47546670
124MP0005000_abnormal_immune_tolerance0.47469380
125MP0002723_abnormal_immune_serum0.46502337
126MP0002452_abnormal_antigen_presenting0.42430178
127MP0000249_abnormal_blood_vessel0.41836208
128MP0005671_abnormal_response_to0.41594292
129MP0002928_abnormal_bile_duct0.41584141
130MP0008873_increased_physiological_sensi0.41390517
131MP0001879_abnormal_lymphatic_vessel0.41287508
132MP0005058_abnormal_lysosome_morphology0.40436706
133MP0002060_abnormal_skin_morphology0.40282498
134MP0003075_altered_response_to0.39984196
135MP0002796_impaired_skin_barrier0.39125145
136MP0001661_extended_life_span0.38898469
137MP0005075_abnormal_melanosome_morpholog0.38444873
138MP0005164_abnormal_response_to0.35682880
139MP0004130_abnormal_muscle_cell0.34862634
140MP0004883_abnormal_blood_vessel0.33894295

Predicted human phenotypes

RankGene SetZ-score
1Intrahepatic cholestasis (HP:0001406)6.94153416
2Abnormality of aromatic amino acid family metabolism (HP:0004338)6.81876587
3Deep venous thrombosis (HP:0002625)6.50514966
4Prolonged partial thromboplastin time (HP:0003645)6.50009606
5Abnormality of monocarboxylic acid metabolism (HP:0010996)6.34898235
6Hypobetalipoproteinemia (HP:0003563)5.72175111
7Xanthomatosis (HP:0000991)5.51633983
8Joint hemorrhage (HP:0005261)5.09595253
9Complement deficiency (HP:0004431)5.02185156
10Hyperlipoproteinemia (HP:0010980)4.83641716
11Hypoglycemic coma (HP:0001325)4.33526981
12Purpura (HP:0000979)4.32018522
13Abnormality of the common coagulation pathway (HP:0010990)4.30970053
14Fat malabsorption (HP:0002630)4.16544913
15Hypolipoproteinemia (HP:0010981)4.12904836
16Abnormality of glutamine family amino acid metabolism (HP:0010902)4.10748508
17Hyperglycinemia (HP:0002154)4.00824505
18Conjugated hyperbilirubinemia (HP:0002908)3.99757079
19Abnormality of pyrimidine metabolism (HP:0004353)3.96526593
20Delayed closure of the anterior fontanelle (HP:0001476)3.94079907
21Abnormality of methionine metabolism (HP:0010901)3.93624764
22Epidermoid cyst (HP:0200040)3.91508421
23Abnormality of aspartate family amino acid metabolism (HP:0010899)3.88699135
24Hyperammonemia (HP:0001987)3.88053845
25Abnormality of sulfur amino acid metabolism (HP:0004339)3.84596574
26Abnormality of the level of lipoprotein cholesterol (HP:0010979)3.82229760
27Abnormality of complement system (HP:0005339)3.76856459
28Hyperglycinuria (HP:0003108)3.68931058
29Abnormality of the intrinsic pathway (HP:0010989)3.60614775
30Abnormality of serine family amino acid metabolism (HP:0010894)3.53139644
31Abnormality of glycine metabolism (HP:0010895)3.53139644
32Flat occiput (HP:0005469)3.50672396
33Ketosis (HP:0001946)3.49377056
34Hypoalphalipoproteinemia (HP:0003233)3.48690018
35Hypoglycemic seizures (HP:0002173)3.36151228
36Flat acetabular roof (HP:0003180)3.34121616
37Prolonged bleeding time (HP:0003010)3.31328203
38Hypercholesterolemia (HP:0003124)3.28526502
39Steatorrhea (HP:0002570)3.22784103
40Systemic lupus erythematosus (HP:0002725)3.17217389
41Abnormality of fatty-acid metabolism (HP:0004359)3.15663844
42Hyperbilirubinemia (HP:0002904)3.14636752
43Abnormality of nucleobase metabolism (HP:0010932)3.13652786
44Recurrent gram-negative bacterial infections (HP:0005420)3.12601338
45Brushfield spots (HP:0001088)3.10825491
46Abnormality of long-chain fatty-acid metabolism (HP:0010964)3.00000890
47Increased mean platelet volume (HP:0011877)2.99651453
48Nasal polyposis (HP:0100582)2.99243155
49Hepatocellular carcinoma (HP:0001402)2.99164227
50Myocardial infarction (HP:0001658)2.94966504
51Abnormal platelet volume (HP:0011876)2.92292685
52Renal cortical cysts (HP:0000803)2.84082878
53Delayed CNS myelination (HP:0002188)2.83498101
54Abnormality of serum amino acid levels (HP:0003112)2.82667495
55Spontaneous abortion (HP:0005268)2.79833725
56Epistaxis (HP:0000421)2.78086691
57Pustule (HP:0200039)2.77783303
58Abnormality of the nasal mucosa (HP:0000433)2.76396026
59Hypochromic microcytic anemia (HP:0004840)2.75872429
60Abnormality of purine metabolism (HP:0004352)2.72215883
61Skin nodule (HP:0200036)2.60886613
62Gingival bleeding (HP:0000225)2.59829559
63Glomerulonephritis (HP:0000099)2.57324817
64Petechiae (HP:0000967)2.54653029
65Metabolic acidosis (HP:0001942)2.52042647
66Generalized aminoaciduria (HP:0002909)2.47029503
67Abnormality of macrophages (HP:0004311)2.46645171
68Hyperinsulinemic hypoglycemia (HP:0000825)2.45055446
69Esophageal varix (HP:0002040)2.43269211
70Vascular calcification (HP:0004934)2.41847747
71Symptomatic seizures (HP:0011145)2.40163396
72Abnormality of dicarboxylic acid metabolism (HP:0010995)2.39678721
73Dicarboxylic aciduria (HP:0003215)2.39678721
74Lethargy (HP:0001254)2.39348640
75Ketoacidosis (HP:0001993)2.37354772
76Menorrhagia (HP:0000132)2.34543240
77Thrombophlebitis (HP:0004418)2.33316698
78Abnormality of carpal bone ossification (HP:0006257)2.32225193
79Pancreatitis (HP:0001733)2.28983991
80Nausea (HP:0002018)2.28646790
81Urinary glycosaminoglycan excretion (HP:0003541)2.26934635
82Mucopolysacchariduria (HP:0008155)2.26934635
83Gout (HP:0001997)2.22528516
84Enlarged kidneys (HP:0000105)2.22311286
85Irritability (HP:0000737)2.22221371
86Impaired platelet aggregation (HP:0003540)2.21183746
87Abnormal platelet function (HP:0011869)2.21183746
88Autoimmune thrombocytopenia (HP:0001973)2.21112041
89Stomatitis (HP:0010280)2.19596360
90Vacuolated lymphocytes (HP:0001922)2.19416511
91Hemorrhage of the eye (HP:0011885)2.18651525
92Dysostosis multiplex (HP:0000943)2.18282803
93Abnormality of the lumbar spine (HP:0100712)2.14869333
94Epiphyseal stippling (HP:0010655)2.14682810
95Acanthocytosis (HP:0001927)2.14030851
96Proximal tubulopathy (HP:0000114)2.11787277
97Keratoconjunctivitis (HP:0001096)2.11274448
98Mitral stenosis (HP:0001718)2.11247961
99Abnormality of proline metabolism (HP:0010907)2.10668941
100Hydroxyprolinuria (HP:0003080)2.10668941
101Cardiovascular calcification (HP:0011915)2.09467319
102Hypercortisolism (HP:0001578)2.08052836
103Ovoid vertebral bodies (HP:0003300)2.07781849
104Malnutrition (HP:0004395)2.07748571
105Abnormal pupillary function (HP:0007686)2.06936535
106Cerebral edema (HP:0002181)2.06862310
107Opisthotonus (HP:0002179)2.06174386
108Abnormality of polysaccharide metabolism (HP:0011012)2.04556103
109Abnormality of glycosaminoglycan metabolism (HP:0004371)2.04556103
110Abnormality of mucopolysaccharide metabolism (HP:0011020)2.04556103
111Amyloidosis (HP:0011034)2.04023834
112Primary adrenal insufficiency (HP:0008207)2.03257665
113Focal segmental glomerulosclerosis (HP:0000097)2.02949687
114Glomerulosclerosis (HP:0000096)2.02804877
115Abnormality of calcium-phosphate metabolism (HP:0100530)2.02332509
116Rickets (HP:0002748)2.02167148
117Late onset (HP:0003584)2.01947149
118Pulmonary embolism (HP:0002204)2.00124993
119Joint swelling (HP:0001386)1.99700528
120Neonatal onset (HP:0003623)1.99616174
121Increased serum ferritin (HP:0003281)1.98978319
122Chronic diarrhea (HP:0002028)1.98452088
123Increased IgM level (HP:0003496)1.97564730
124Abnormal gallbladder morphology (HP:0012437)1.97053480
125Hypophosphatemic rickets (HP:0004912)1.95391431
126Osteomalacia (HP:0002749)1.94911232
127Sensorimotor neuropathy (HP:0007141)1.94493226
128Bile duct proliferation (HP:0001408)1.93798967
129Abnormal biliary tract physiology (HP:0012439)1.93798967
130Abnormal tarsal ossification (HP:0008369)1.93496341
131Abnormality of urine glucose concentration (HP:0011016)1.93126632
132Glycosuria (HP:0003076)1.93126632
133Vomiting (HP:0002013)1.91293893
134Spastic diplegia (HP:0001264)1.90807521
135Abnormality of iron homeostasis (HP:0011031)1.89538201
136Abnormal enzyme/coenzyme activity (HP:0012379)1.88717269
137Elevated hepatic transaminases (HP:0002910)1.88448223
138Spinal cord lesions (HP:0100561)1.87960188
139Syringomyelia (HP:0003396)1.87960188
140Delayed cranial suture closure (HP:0000270)1.86850508
141Nephritis (HP:0000123)1.85717332
142Cholelithiasis (HP:0001081)1.84125547
143Abnormality of transition element cation homeostasis (HP:0011030)1.83866772
144Flared iliac wings (HP:0002869)1.83822237
145Poikilocytosis (HP:0004447)1.82890002
146Abnormality of the Achilles tendon (HP:0005109)1.81703332
147Chronic mucocutaneous candidiasis (HP:0002728)1.81078978
148Recurrent cutaneous fungal infections (HP:0011370)1.81078978
149Abnormal epiphyseal ossification (HP:0010656)1.80283496
150Abnormal gallbladder physiology (HP:0012438)1.79535186
151Widely patent fontanelles and sutures (HP:0004492)1.79132392
152Alopecia of scalp (HP:0002293)1.79109717
153Abnormality of the acetabulum (HP:0003170)1.75828003
154Abnormality of vitamin metabolism (HP:0100508)1.75679576
155Metaphyseal irregularity (HP:0003025)1.75006088

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BCKDK5.39410855
2MAP3K135.29463124
3IRAK45.17274881
4PASK4.89838161
5FGFR43.42891362
6IRAK33.35612351
7MAP3K142.84973076
8ERN12.76909130
9FGR2.59051791
10SIK12.53386660
11MAP3K32.41200311
12ACVR1B2.38926248
13INSRR2.31092763
14TAOK32.29211976
15MAP3K122.24584443
16KDR2.11062279
17BLK2.06124097
18MAP2K32.04142405
19TYK22.00643940
20TBK11.88889311
21ERBB41.84714994
22PIK3CG1.69369525
23IRAK11.64730585
24IKBKE1.59708807
25MST1R1.53497978
26IRAK21.52841850
27MST41.51778607
28NME21.45903683
29TXK1.43549364
30PINK11.41810575
31CAMKK11.41354485
32PRKG21.36693570
33FLT31.33702484
34TGFBR21.32951677
35MAP4K11.31749667
36GRK11.26284213
37BMX1.25508979
38MET1.24484691
39MYLK1.22851473
40JAK11.20526861
41PDPK11.20099820
42NEK91.18399697
43MATK1.18307071
44MAP3K111.17724871
45WNK41.15784686
46FGFR11.14456988
47RIPK41.14381666
48LMTK21.13228077
49FRK1.10276688
50STK241.09932610
51ZAK1.08781032
52IKBKB1.07214235
53TEC1.06786187
54TAOK21.06168024
55ZAP701.03998072
56MAPK111.01919853
57NLK1.01673640
58TESK21.00749288
59STK391.00600096
60TIE10.99532400
61PBK0.98974675
62ABL20.98240664
63BTK0.96390573
64JAK30.92985429
65JAK20.92854752
66PDGFRA0.92350922
67BMPR20.91440056
68KIT0.91176142
69MAP2K60.91058961
70PRKAA20.90674746
71DDR20.90468774
72STK38L0.90385766
73CSK0.89279339
74PAK40.88471713
75PDK10.88427666
76MAP3K10.86945430
77AKT30.86776273
78STK100.84396841
79LRRK20.84193399
80EIF2AK20.82630980
81EPHB20.81972754
82MAP2K40.81493088
83CDC42BPA0.79605221
84ICK0.79346221
85ILK0.77399443
86PTK20.76578965
87TRIB30.76038055
88STK160.75500399
89ITK0.73701777
90MAPK150.71059284
91CSF1R0.69644861
92GRK60.69082781
93MAPK40.64680916
94MAP3K80.61881125
95PTK60.61571852
96MAPKAPK30.61371306
97CHUK0.60688981
98LATS20.60655018
99PKN20.60152668
100LYN0.59094856
101CDK60.58323855
102PRKCQ0.57486086
103NUAK10.56721511
104RET0.56333625
105MAP2K20.55028261
106GSK3A0.54813476
107FGFR30.52467813
108EPHA20.51939801
109EIF2AK30.50623751
110IGF1R0.49616709
111PIM20.47579588
112SYK0.46190667
113TYRO30.43858856
114TESK10.41994312
115PRKCD0.41779657
116FYN0.41172146
117DAPK30.39769326
118PIK3CA0.39613003
119PIM10.39267771
120MAP3K70.39220755
121LCK0.39057150
122SRC0.38144196
123MAPK70.37567660
124STK30.37077841
125EPHB10.36935169
126EPHA30.36504123
127PRPF4B0.36120551
128SGK20.36066620
129MAP3K20.35860226
130DYRK1B0.35109300
131PRKACG0.34937930
132ABL10.34826919
133ADRBK20.33571182
134RPS6KB20.33552049
135TNIK0.33499900
136ERBB20.32451211
137EIF2AK10.31369632
138CAMK2G0.28901278
139LATS10.28677013
140KSR20.28300282
141RIPK10.27334566
142PRKCZ0.26938414
143MAP2K10.25548100
144MAPK120.25444124
145SIK30.25234497
146MAP3K50.24932732
147MAP3K100.22678602
148MAPK30.21442815

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary bile acid biosynthesis_Homo sapiens_hsa001204.36000626
2Ascorbate and aldarate metabolism_Homo sapiens_hsa000533.76328113
3Nitrogen metabolism_Homo sapiens_hsa009103.09347623
4Complement and coagulation cascades_Homo sapiens_hsa046102.86589912
5Pentose and glucuronate interconversions_Homo sapiens_hsa000402.85536564
6Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004002.81805345
7Arginine biosynthesis_Homo sapiens_hsa002202.70519165
8Tryptophan metabolism_Homo sapiens_hsa003802.59806612
9Other glycan degradation_Homo sapiens_hsa005112.48079197
10Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010402.46262247
11Glycine, serine and threonine metabolism_Homo sapiens_hsa002602.38546841
12Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006302.37368396
13Drug metabolism - cytochrome P450_Homo sapiens_hsa009822.35993955
14Fatty acid degradation_Homo sapiens_hsa000712.33909700
15Caffeine metabolism_Homo sapiens_hsa002322.30160724
16Steroid hormone biosynthesis_Homo sapiens_hsa001402.23316646
17Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.17256638
18Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009802.16523331
19Chemical carcinogenesis_Homo sapiens_hsa052042.16278448
20Drug metabolism - other enzymes_Homo sapiens_hsa009832.14636084
21Peroxisome_Homo sapiens_hsa041462.14382566
22Staphylococcus aureus infection_Homo sapiens_hsa051502.12119819
23Retinol metabolism_Homo sapiens_hsa008302.03252994
24beta-Alanine metabolism_Homo sapiens_hsa004101.96664102
25Histidine metabolism_Homo sapiens_hsa003401.94800557
26Butanoate metabolism_Homo sapiens_hsa006501.84493705
27PPAR signaling pathway_Homo sapiens_hsa033201.67557643
28Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.63478628
29Propanoate metabolism_Homo sapiens_hsa006401.60348662
30Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.59637911
31Mineral absorption_Homo sapiens_hsa049781.58116393
32Fatty acid metabolism_Homo sapiens_hsa012121.56685974
33Selenocompound metabolism_Homo sapiens_hsa004501.46352716
34Starch and sucrose metabolism_Homo sapiens_hsa005001.45034537
35Phenylalanine metabolism_Homo sapiens_hsa003601.42754297
36Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.40640241
37Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.36287290
38Tyrosine metabolism_Homo sapiens_hsa003501.36074355
39Folate biosynthesis_Homo sapiens_hsa007901.31890517
40Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.31696254
41Bile secretion_Homo sapiens_hsa049761.27258106
42Fatty acid elongation_Homo sapiens_hsa000621.26951795
43Maturity onset diabetes of the young_Homo sapiens_hsa049501.26206280
44ABC transporters_Homo sapiens_hsa020101.24252072
45Sulfur metabolism_Homo sapiens_hsa009201.22269476
46Steroid biosynthesis_Homo sapiens_hsa001001.20240093
47Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.15937756
48Pyruvate metabolism_Homo sapiens_hsa006201.11219846
49Autoimmune thyroid disease_Homo sapiens_hsa053201.09435535
50Vitamin digestion and absorption_Homo sapiens_hsa049771.07494397
51Cysteine and methionine metabolism_Homo sapiens_hsa002701.06928749
52Arginine and proline metabolism_Homo sapiens_hsa003301.05565823
532-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.04712282
54Sphingolipid metabolism_Homo sapiens_hsa006001.01909975
55Fat digestion and absorption_Homo sapiens_hsa049751.01548233
56One carbon pool by folate_Homo sapiens_hsa006700.90503650
57Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.90093852
58Cyanoamino acid metabolism_Homo sapiens_hsa004600.88680392
59Biosynthesis of amino acids_Homo sapiens_hsa012300.88544700
60Carbon metabolism_Homo sapiens_hsa012000.87043924
61Vitamin B6 metabolism_Homo sapiens_hsa007500.82205246
62Glutathione metabolism_Homo sapiens_hsa004800.81932641
63Type I diabetes mellitus_Homo sapiens_hsa049400.79831310
64Protein digestion and absorption_Homo sapiens_hsa049740.76972894
65Sulfur relay system_Homo sapiens_hsa041220.76570208
66Lysosome_Homo sapiens_hsa041420.75164950
67Leukocyte transendothelial migration_Homo sapiens_hsa046700.72311085
68Lysine degradation_Homo sapiens_hsa003100.69309800
69Toxoplasmosis_Homo sapiens_hsa051450.69177217
70Platelet activation_Homo sapiens_hsa046110.69029671
71B cell receptor signaling pathway_Homo sapiens_hsa046620.68372560
72Chemokine signaling pathway_Homo sapiens_hsa040620.66176112
73Hematopoietic cell lineage_Homo sapiens_hsa046400.63216604
74Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.57443772
75Antigen processing and presentation_Homo sapiens_hsa046120.56520360
76Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.53578567
77Glycerolipid metabolism_Homo sapiens_hsa005610.53474703
78Osteoclast differentiation_Homo sapiens_hsa043800.52849510
79Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.52607981
80Amoebiasis_Homo sapiens_hsa051460.52093117
81ECM-receptor interaction_Homo sapiens_hsa045120.48699783
82TNF signaling pathway_Homo sapiens_hsa046680.47371597
83Asthma_Homo sapiens_hsa053100.47281399
84Pentose phosphate pathway_Homo sapiens_hsa000300.47255384
85Metabolic pathways_Homo sapiens_hsa011000.47138654
86Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.44870052
87Influenza A_Homo sapiens_hsa051640.43643084
88Salmonella infection_Homo sapiens_hsa051320.40296286
89Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.38260183
90Tuberculosis_Homo sapiens_hsa051520.35838787
91Carbohydrate digestion and absorption_Homo sapiens_hsa049730.34840579
92Pancreatic cancer_Homo sapiens_hsa052120.34567104
93Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.33929949
94Rheumatoid arthritis_Homo sapiens_hsa053230.30646286
95Prion diseases_Homo sapiens_hsa050200.29098869
96Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.28350701
97Acute myeloid leukemia_Homo sapiens_hsa052210.28217110
98Galactose metabolism_Homo sapiens_hsa000520.27789995
99alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.26856914
100Viral myocarditis_Homo sapiens_hsa054160.26772626
101Fatty acid biosynthesis_Homo sapiens_hsa000610.25393705
102Glycosaminoglycan degradation_Homo sapiens_hsa005310.20756267
103Linoleic acid metabolism_Homo sapiens_hsa005910.20708663
104Pertussis_Homo sapiens_hsa051330.16964628
105Insulin resistance_Homo sapiens_hsa049310.13344657
106NF-kappa B signaling pathway_Homo sapiens_hsa040640.12390984
107Fructose and mannose metabolism_Homo sapiens_hsa000510.11920508
108Adipocytokine signaling pathway_Homo sapiens_hsa049200.10713118
109RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.10607851
110Intestinal immune network for IgA production_Homo sapiens_hsa046720.09517193
111African trypanosomiasis_Homo sapiens_hsa051430.06922934
112Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.06439150
113Graft-versus-host disease_Homo sapiens_hsa053320.06347373
114Leishmaniasis_Homo sapiens_hsa051400.06310062
115Toll-like receptor signaling pathway_Homo sapiens_hsa046200.05489561
116Arachidonic acid metabolism_Homo sapiens_hsa005900.04770230
117Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.04385181
118Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.04366725
119Glycerophospholipid metabolism_Homo sapiens_hsa005640.04030856
120Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.02220741
121Legionellosis_Homo sapiens_hsa051340.01376707
122Renin-angiotensin system_Homo sapiens_hsa046140.00881238
123Hepatitis C_Homo sapiens_hsa051600.00165043
124Primary immunodeficiency_Homo sapiens_hsa05340-0.0713932
125Malaria_Homo sapiens_hsa05144-0.0654965
126Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060-0.0248157
127Allograft rejection_Homo sapiens_hsa05330-0.0239615
128Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932-0.0174720
129Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321-0.0166278
130Measles_Homo sapiens_hsa05162-0.0150238
131Protein export_Homo sapiens_hsa03060-0.0140597

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