ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	cell migration in hindbrain (GO:0021535)	4.39479356
2	cerebellar granule cell differentiation (GO:0021707)	3.76072483
3	regulation of ARF protein signal transduction (GO:0032012)	3.71160289
4	pyrimidine nucleobase catabolic process (GO:0006208)	3.50733122
5	axonal fasciculation (GO:0007413)	3.38771546
6	layer formation in cerebral cortex (GO:0021819)	3.34537531
7	positive regulation of excitatory postsynaptic membrane potential (GO:2000463)	3.31679023
8	regulation of NFAT protein import into nucleus (GO:0051532)	3.29749858
9	synaptic vesicle exocytosis (GO:0016079)	3.25011312
10	negative regulation of erythrocyte differentiation (GO:0045647)	3.24176988
11	neuron recognition (GO:0008038)	3.20898420
12	regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act	3.14564136
13	ionotropic glutamate receptor signaling pathway (GO:0035235)	3.01396248
14	establishment of mitochondrion localization (GO:0051654)	2.99562515
15	positive regulation of CREB transcription factor activity (GO:0032793)	2.96106272
16	histone H3-K36 demethylation (GO:0070544)	2.95627872
17	G-protein coupled acetylcholine receptor signaling pathway (GO:0007213)	2.95572831
18	mannose metabolic process (GO:0006013)	2.94764771
19	postsynaptic membrane organization (GO:0001941)	2.92503111
20	regulation of synaptic vesicle exocytosis (GO:2000300)	2.90200774
21	regulation of ARF GTPase activity (GO:0032312)	2.88795459
22	synaptic vesicle docking involved in exocytosis (GO:0016081)	2.85785057
23	neuron cell-cell adhesion (GO:0007158)	2.85699589
24	positive regulation of synapse maturation (GO:0090129)	2.84866694
25	synaptic vesicle maturation (GO:0016188)	2.83930121
26	histone H3-K4 trimethylation (GO:0080182)	2.83717758
27	vocalization behavior (GO:0071625)	2.83540092
28	negative regulation of amyloid precursor protein catabolic process (GO:1902992)	2.78583711
29	establishment of nucleus localization (GO:0040023)	2.74761975
30	establishment of mitochondrion localization, microtubule-mediated (GO:0034643)	2.74663383
31	mitochondrion transport along microtubule (GO:0047497)	2.74663383
32	planar cell polarity pathway involved in neural tube closure (GO:0090179)	2.74437764
33	neuronal ion channel clustering (GO:0045161)	2.71938925
34	positive regulation of synaptic transmission, dopaminergic (GO:0032226)	2.70931656
35	camera-type eye morphogenesis (GO:0048593)	2.70780935
36	nucleobase catabolic process (GO:0046113)	2.70115939
37	locomotory exploration behavior (GO:0035641)	2.67887177
38	axon extension (GO:0048675)	2.64712125
39	glutamate secretion (GO:0014047)	2.63108131
40	regulation of glycogen (starch) synthase activity (GO:2000465)	2.62981018
41	regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)	2.62696085
42	cellular response to catecholamine stimulus (GO:0071870)	2.59899499
43	cellular response to monoamine stimulus (GO:0071868)	2.59899499
44	signal complex assembly (GO:0007172)	2.59623216
45	dopamine receptor signaling pathway (GO:0007212)	2.58674498
46	cell-cell junction maintenance (GO:0045217)	2.57938343
47	adenylate cyclase-activating dopamine receptor signaling pathway (GO:0007191)	2.57446935
48	semaphorin-plexin signaling pathway (GO:0071526)	2.56858171
49	peptidyl-tyrosine autophosphorylation (GO:0038083)	2.56183760
50	regulation of glutamate receptor signaling pathway (GO:1900449)	2.55499013
51	histone lysine demethylation (GO:0070076)	2.54854227
52	regulation of short-term neuronal synaptic plasticity (GO:0048172)	2.51398910
53	dendritic spine morphogenesis (GO:0060997)	2.49895109
54	activated T cell proliferation (GO:0050798)	2.49642158
55	presynaptic membrane organization (GO:0097090)	2.46322643
56	intracellular estrogen receptor signaling pathway (GO:0030520)	2.44412518
57	histone H4 deacetylation (GO:0070933)	2.43475881
58	central nervous system projection neuron axonogenesis (GO:0021952)	2.43377011
59	negative regulation of cell killing (GO:0031342)	2.42430782
60	negative regulation of leukocyte mediated cytotoxicity (GO:0001911)	2.42430782
61	regulation of respiratory gaseous exchange by neurological system process (GO:0002087)	2.38312378
62	histone H3-K9 modification (GO:0061647)	2.37955197
63	regulation of synaptic vesicle transport (GO:1902803)	2.36533996
64	cellular response to prostaglandin stimulus (GO:0071379)	2.36052012
65	presynaptic membrane assembly (GO:0097105)	2.33402762
66	positive regulation of Rap GTPase activity (GO:0032854)	2.33183010
67	synapse assembly (GO:0007416)	2.32977596
68	histone demethylation (GO:0016577)	2.31687004
69	histone H3-K9 demethylation (GO:0033169)	2.31509007
70	insulin-like growth factor receptor signaling pathway (GO:0048009)	2.31264052
71	regulation of synapse maturation (GO:0090128)	2.28958021
72	neuron projection extension (GO:1990138)	2.28550692
73	exploration behavior (GO:0035640)	2.26588261
74	neurotransmitter secretion (GO:0007269)	2.26441428
75	negative regulation of glial cell proliferation (GO:0060253)	2.26026309
76	positive regulation of transcription from RNA polymerase II promoter in response to stress (GO:00360	2.25494414
77	protein localization to synapse (GO:0035418)	2.25475595
78	neuromuscular process controlling balance (GO:0050885)	2.25403343
79	auditory behavior (GO:0031223)	2.25386372
80	positive regulation of dendritic spine morphogenesis (GO:0061003)	2.25316655
81	cell differentiation in hindbrain (GO:0021533)	2.22840498
82	negative regulation of axonogenesis (GO:0050771)	2.22836783
83	stress granule assembly (GO:0034063)	2.22792755
84	phosphatidylinositol-3-phosphate biosynthetic process (GO:0036092)	2.21831756
85	regulation of Rap GTPase activity (GO:0032317)	2.21439231
86	dendrite morphogenesis (GO:0048813)	2.19057573
87	positive regulation of type I interferon-mediated signaling pathway (GO:0060340)	2.18524269
88	cerebellar Purkinje cell differentiation (GO:0021702)	2.18347446
89	neurotransmitter-gated ion channel clustering (GO:0072578)	2.17271649
90	positive regulation of membrane potential (GO:0045838)	2.15788496
91	synaptic vesicle endocytosis (GO:0048488)	2.15524949
92	cell junction maintenance (GO:0034331)	2.13627322
93	positive regulation of histone deacetylation (GO:0031065)	2.13355650
94	response to nerve growth factor (GO:1990089)	2.12945401
95	cellular response to nerve growth factor stimulus (GO:1990090)	2.12945401
96	dendrite development (GO:0016358)	2.12818814
97	regulation of synapse structural plasticity (GO:0051823)	2.12799413
98	positive regulation of calcium ion-dependent exocytosis (GO:0045956)	2.11828529
99	regulation of axonogenesis (GO:0050770)	2.11561953
100	activation of protein kinase A activity (GO:0034199)	2.10983742

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	EZH2_22144423_ChIP-Seq_EOC_Human	4.40180329
2	EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse	3.00269290
3	DROSHA_22980978_ChIP-Seq_HELA_Human	2.77910766
4	KDM2B_26808549_Chip-Seq_SUP-B15_Human	2.59063755
5	THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse	2.57601638
6	KDM2B_26808549_Chip-Seq_K562_Human	2.36304357
7	VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human	2.30374755
8	KDM2B_26808549_Chip-Seq_DND41_Human	2.28094786
9	ZFP281_18757296_ChIP-ChIP_E14_Mouse	2.11517343
10	JARID2_20064375_ChIP-Seq_MESCs_Mouse	2.11278114
11	KDM2B_26808549_Chip-Seq_SIL-ALL_Human	2.10724972
12	LXR_22292898_ChIP-Seq_THP-1_Human	2.07222944
13	RBPJ_22232070_ChIP-Seq_NCS_Mouse	2.03602275
14	MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human	2.00720530
15	KDM2B_26808549_Chip-Seq_JURKAT_Human	1.99536222
16	EZH2_27304074_Chip-Seq_ESCs_Mouse	1.98438161
17	EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse	1.97799693
18	JARID2_20075857_ChIP-Seq_MESCs_Mouse	1.97676383
19	RNF2_27304074_Chip-Seq_ESCs_Mouse	1.97471365
20	EZH2_18974828_ChIP-Seq_MESCs_Mouse	1.94433037
21	RNF2_18974828_ChIP-Seq_MESCs_Mouse	1.94433037
22	TCF7_22412390_ChIP-Seq_EML_Mouse	1.94052972
23	CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons	1.92207051
24	SUZ12_27294783_Chip-Seq_ESCs_Mouse	1.91838290
25	ERG_21242973_ChIP-ChIP_JURKAT_Human	1.91300865
26	WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse	1.89223579
27	ZFP281_27345836_Chip-Seq_ESCs_Mouse	1.88317646
28	NR4A2_19515692_ChIP-ChIP_MN9D_Mouse	1.88003120
29	EZH2_27294783_Chip-Seq_ESCs_Mouse	1.84342098
30	MYC_22102868_ChIP-Seq_BL_Human	1.84126010
31	VDR_21846776_ChIP-Seq_THP-1_Human	1.81982334
32	KDM2B_26808549_Chip-Seq_HPB-ALL_Human	1.81037261
33	RARB_27405468_Chip-Seq_BRAIN_Mouse	1.80332187
34	EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human	1.79902851
35	SMAD3_22036565_ChIP-Seq_ESCs_Mouse	1.78844309
36	DNAJC2_21179169_ChIP-ChIP_NT2_Human	1.78282584
37	SUZ12_20075857_ChIP-Seq_MESCs_Mouse	1.68324428
38	SUZ12_18692474_ChIP-Seq_MESCs_Mouse	1.64344519
39	IKZF1_21737484_ChIP-ChIP_HCT116_Human	1.60114754
40	TFAP2C_20629094_ChIP-Seq_MCF-7_Human	1.60022200
41	ZFP322A_24550733_ChIP-Seq_MESCs_Mouse	1.58941352
42	REST_21632747_ChIP-Seq_MESCs_Mouse	1.58726035
43	SUZ12_18555785_ChIP-Seq_MESCs_Mouse	1.58008941
44	MTF2_20144788_ChIP-Seq_MESCs_Mouse	1.54881576
45	SUZ12_16625203_ChIP-ChIP_MESCs_Mouse	1.51804326
46	DMRT1_23473982_ChIP-Seq_TESTES_Mouse	1.49508645
47	SUZ12_18692474_ChIP-Seq_MEFs_Mouse	1.48684326
48	SUZ12_18974828_ChIP-Seq_MESCs_Mouse	1.48267232
49	CTCF_27219007_Chip-Seq_Bcells_Human	1.45681207
50	STAT6_21828071_ChIP-Seq_BEAS2B_Human	1.44343384
51	CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human	1.43534745
52	RCOR2_21632747_ChIP-Seq_MESCs_Mouse	1.41348471
53	OLIG2_26023283_ChIP-Seq_AINV15_Mouse	1.40776446
54	EED_16625203_ChIP-ChIP_MESCs_Mouse	1.39743118
55	GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human	1.39285725
56	CREB1_26743006_Chip-Seq_LNCaP_Human	1.38970529
57	ELK3_25401928_ChIP-Seq_HUVEC_Human	1.36277769
58	SMC4_20622854_ChIP-Seq_HELA_Human	1.30460477
59	REST_18959480_ChIP-ChIP_MESCs_Mouse	1.29323037
60	CBX2_27304074_Chip-Seq_ESCs_Mouse	1.29094948
61	TCF3_18467660_ChIP-ChIP_MESCs_Mouse	1.27716318
62	RING1B_27294783_Chip-Seq_ESCs_Mouse	1.27616990
63	RING1B_27294783_Chip-Seq_NPCs_Mouse	1.24891165
64	WT1_25993318_ChIP-Seq_PODOCYTE_Human	1.22699169
65	SA1_27219007_Chip-Seq_ERYTHROID_Human	1.20713792
66	NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse	1.20258189
67	RACK7_27058665_Chip-Seq_MCF-7_Human	1.19863473
68	ZFP281_18358816_ChIP-ChIP_MESCs_Mouse	1.18670164
69	CREB1_26743006_Chip-Seq_LNCaP-abl_Human	1.17297059
70	MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human	1.16589945
71	TP53_20018659_ChIP-ChIP_R1E_Mouse	1.14214473
72	P68_20966046_ChIP-Seq_HELA_Human	1.10527523
73	AR_21572438_ChIP-Seq_LNCaP_Human	1.09899418
74	E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human	1.09759427
75	PHC1_16625203_ChIP-ChIP_MESCs_Mouse	1.08783540
76	UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human	1.07583076
77	CTCF_27219007_Chip-Seq_ERYTHROID_Human	1.07547582
78	TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse	1.07161770
79	P300_27058665_Chip-Seq_ZR-75-30cells_Human	1.05294829
80	ISL1_27105846_Chip-Seq_CPCs_Mouse	1.03724729
81	RCOR3_21632747_ChIP-Seq_MESCs_Mouse	1.01371400
82	GATA1_19941827_ChIP-Seq_MEL_Mouse	1.01292313
83	MAF_26560356_Chip-Seq_TH1_Human	1.00097186
84	ESR2_21235772_ChIP-Seq_MCF-7_Human	0.99975680
85	UTX_26944678_Chip-Seq_JUKART_Human	0.99559623
86	SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse	0.98798386
87	NFIB_24661679_ChIP-Seq_LUNG_Mouse	0.98261030
88	VDR_24763502_ChIP-Seq_THP-1_Human	0.98197160
89	SRY_22984422_ChIP-ChIP_TESTIS_Rat	0.98076905
90	RUNX1_27514584_Chip-Seq_MCF-7_Human	0.97157051
91	MAF_26560356_Chip-Seq_TH2_Human	0.96635481
92	OCT4_19829295_ChIP-Seq_ESCs_Human	0.96074212
93	PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse	0.93041996
94	MYC_27129775_Chip-Seq_CORNEA_Mouse	0.90633835
95	AR_19668381_ChIP-Seq_PC3_Human	0.89152389
96	TET1_21490601_ChIP-Seq_MESCs_Mouse	0.87500431
97	ELK4_26923725_Chip-Seq_MESODERM_Mouse	0.86942547
98	SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse	0.85782380
99	STAT6_20620947_ChIP-Seq_CD4_POS_T_Human	0.84442029
100	SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human	0.84399454

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0004859_abnormal_synaptic_plasticity	4.82519344
2	MP0002822_catalepsy	2.94485919
3	MP0004270_analgesia	2.87725043
4	MP0003122_maternal_imprinting	2.74391058
5	MP0000778_abnormal_nervous_system	2.63319856
6	MP0004858_abnormal_nervous_system	2.60605376
7	MP0005423_abnormal_somatic_nervous	2.60438904
8	MP0003635_abnormal_synaptic_transmissio	2.57151859
9	MP0005409_darkened_coat_color	2.40544352
10	MP0002249_abnormal_larynx_morphology	2.39418507
11	MP0000566_synostosis	2.36936129
12	MP0003880_abnormal_central_pattern	2.24402637
13	MP0002063_abnormal_learning/memory/cond	2.23821704
14	MP0003787_abnormal_imprinting	1.97078068
15	MP0002734_abnormal_mechanical_nocicepti	1.76063551
16	MP0003123_paternal_imprinting	1.71192475
17	MP0008569_lethality_at_weaning	1.70778213
18	MP0002064_seizures	1.68313127
19	MP0003705_abnormal_hypodermis_morpholog	1.67621974
20	MP0000955_abnormal_spinal_cord	1.64764328
21	MP0003329_amyloid_beta_deposits	1.62069624
22	MP0004130_abnormal_muscle_cell	1.57016997
23	MP0009278_abnormal_bone_marrow	1.52748464
24	MP0002653_abnormal_ependyma_morphology	1.52611722
25	MP0002572_abnormal_emotion/affect_behav	1.52351505
26	MP0002735_abnormal_chemical_nociception	1.47620705
27	MP0004811_abnormal_neuron_physiology	1.47211827
28	MP0001188_hyperpigmentation	1.43626639
29	MP0003283_abnormal_digestive_organ	1.43564662
30	MP0002184_abnormal_innervation	1.38677822
31	MP0003938_abnormal_ear_development	1.36675399
32	MP0001486_abnormal_startle_reflex	1.34408718
33	MP0003121_genomic_imprinting	1.32876430
34	MP0002882_abnormal_neuron_morphology	1.31971648
35	MP0005394_taste/olfaction_phenotype	1.30918456
36	MP0005499_abnormal_olfactory_system	1.30918456
37	MP0002733_abnormal_thermal_nociception	1.30479974
38	MP0002152_abnormal_brain_morphology	1.29792264
39	MP0004885_abnormal_endolymph	1.29300817
40	MP0002557_abnormal_social/conspecific_i	1.28044870
41	MP0009745_abnormal_behavioral_response	1.26428387
42	MP0001970_abnormal_pain_threshold	1.26182353
43	MP0002009_preneoplasia	1.25794168
44	MP0003879_abnormal_hair_cell	1.24853371
45	MP0003861_abnormal_nervous_system	1.23004970
46	MP0000462_abnormal_digestive_system	1.19657367
47	MP0005076_abnormal_cell_differentiation	1.17388230
48	MP0002396_abnormal_hematopoietic_system	1.16529652
49	MP0003115_abnormal_respiratory_system	1.14791095
50	MP0001958_emphysema	1.14157907
51	MP0002067_abnormal_sensory_capabilities	1.12865465
52	MP0000534_abnormal_ureter_morphology	1.12407863
53	MP0001502_abnormal_circadian_rhythm	1.11783998
54	MP0002272_abnormal_nervous_system	1.11148067
55	MP0004742_abnormal_vestibular_system	1.06615882
56	MP0001346_abnormal_lacrimal_gland	1.05286453
57	MP0003690_abnormal_glial_cell	1.04429039
58	MP0005503_abnormal_tendon_morphology	1.03905962
59	MP0003183_abnormal_peptide_metabolism	1.02730327
60	MP0002932_abnormal_joint_morphology	1.02027496
61	MP0001348_abnormal_lacrimal_gland	1.01195025
62	MP0003942_abnormal_urinary_system	1.00570530
63	MP0003634_abnormal_glial_cell	1.00182375
64	MP0001943_abnormal_respiration	0.99977994
65	MP0002116_abnormal_craniofacial_bone	0.99673239
66	MP0001440_abnormal_grooming_behavior	0.97539381
67	MP0002066_abnormal_motor_capabilities/c	0.96005455
68	MP0006276_abnormal_autonomic_nervous	0.95530880
69	MP0001968_abnormal_touch/_nociception	0.95157976
70	MP0005248_abnormal_Harderian_gland	0.91109948
71	MP0008260_abnormal_autophagy	0.90335248
72	MP0003948_abnormal_gas_homeostasis	0.90104057
73	MP0003385_abnormal_body_wall	0.87693276
74	MP0003300_gastrointestinal_ulcer	0.87304892
75	MP0002089_abnormal_postnatal_growth/wei	0.83493443
76	MP0002081_perinatal_lethality	0.83393170
77	MP0000049_abnormal_middle_ear	0.83155375
78	MP0004924_abnormal_behavior	0.80986665
79	MP0005386_behavior/neurological_phenoty	0.80986665
80	MP0002909_abnormal_adrenal_gland	0.80668497
81	MP0000026_abnormal_inner_ear	0.80306795
82	MP0002752_abnormal_somatic_nervous	0.76638051
83	MP0000631_abnormal_neuroendocrine_gland	0.75533418
84	MP0003763_abnormal_thymus_physiology	0.74027443
85	MP0001270_distended_abdomen	0.73090904
86	MP0000428_abnormal_craniofacial_morphol	0.72784067
87	MP0000678_abnormal_parathyroid_gland	0.71500999
88	MP0001849_ear_inflammation	0.70979484
89	MP0005666_abnormal_adipose_tissue	0.70791364
90	MP0009379_abnormal_foot_pigmentation	0.69724189
91	MP0003866_abnormal_defecation	0.69389692
92	MP0001177_atelectasis	0.69078199
93	MP0010770_preweaning_lethality	0.69038317
94	MP0002082_postnatal_lethality	0.69038317
95	MP0010769_abnormal_survival	0.69026186
96	MP0003091_abnormal_cell_migration	0.67237833
97	MP0002114_abnormal_axial_skeleton	0.66661713
98	MP0002069_abnormal_eating/drinking_beha	0.66592293
99	MP0000733_abnormal_muscle_development	0.65006018
100	MP0001299_abnormal_eye_distance/	0.64417516

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Obstructive sleep apnea (HP:0002870)	4.23664410
2	Abnormality of the fingertips (HP:0001211)	3.55527283
3	Papilledema (HP:0001085)	2.97312112
4	Abnormality of the aortic arch (HP:0012303)	2.87835560
5	Ankle clonus (HP:0011448)	2.72247847
6	Broad face (HP:0000283)	2.66942581
7	Hyperacusis (HP:0010780)	2.57324700
8	Annular pancreas (HP:0001734)	2.50250868
9	Short 4th metacarpal (HP:0010044)	2.43723198
10	Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)	2.43723198
11	Genetic anticipation (HP:0003743)	2.43431470
12	Macroorchidism (HP:0000053)	2.41466696
13	Shallow orbits (HP:0000586)	2.39160098
14	Turricephaly (HP:0000262)	2.36524958
15	Bronchomalacia (HP:0002780)	2.33708948
16	Pointed chin (HP:0000307)	2.33252465
17	Sleep apnea (HP:0010535)	2.26615133
18	Trigonocephaly (HP:0000243)	2.25917289
19	Metaphyseal cupping (HP:0003021)	2.19545756
20	Supranuclear gaze palsy (HP:0000605)	2.18102960
21	Neoplasm of the heart (HP:0100544)	2.17637227
22	Broad palm (HP:0001169)	2.16183043
23	Disproportionate tall stature (HP:0001519)	2.16168161
24	Heterotopia (HP:0002282)	2.13347607
25	Long palpebral fissure (HP:0000637)	2.13010636
26	Broad metatarsal (HP:0001783)	2.09898723
27	Diplopia (HP:0000651)	2.07869419
28	Abnormality of binocular vision (HP:0011514)	2.07869419
29	Germ cell neoplasia (HP:0100728)	2.07702148
30	Cerebral aneurysm (HP:0004944)	2.04454035
31	Precocious puberty (HP:0000826)	2.04189975
32	Hepatoblastoma (HP:0002884)	2.00298351
33	Focal seizures (HP:0007359)	1.97556873
34	Spastic gait (HP:0002064)	1.95895009
35	Truncal ataxia (HP:0002078)	1.95361739
36	Stereotypic behavior (HP:0000733)	1.94615425
37	Neonatal hypoglycemia (HP:0001998)	1.94518734
38	Abnormality of the distal phalanx of the thumb (HP:0009617)	1.94436939
39	Lower limb asymmetry (HP:0100559)	1.94117484
40	Hypoventilation (HP:0002791)	1.93578310
41	Vitreoretinal degeneration (HP:0000655)	1.91366987
42	Myokymia (HP:0002411)	1.88987268
43	Sporadic (HP:0003745)	1.88449313
44	Deep palmar crease (HP:0006191)	1.87205961
45	Epileptic encephalopathy (HP:0200134)	1.85059558
46	Supernumerary ribs (HP:0005815)	1.82250296
47	Abnormality of the intervertebral disk (HP:0005108)	1.80986622
48	Tracheomalacia (HP:0002779)	1.80776881
49	Abnormality of the 4th metacarpal (HP:0010012)	1.80144429
50	Thin bony cortex (HP:0002753)	1.79739723
51	Neurofibrillary tangles (HP:0002185)	1.77762842
52	Progressive cerebellar ataxia (HP:0002073)	1.77086384
53	Spinal canal stenosis (HP:0003416)	1.77043419
54	Narrow palate (HP:0000189)	1.76863948
55	Tented upper lip vermilion (HP:0010804)	1.76221180
56	Amblyopia (HP:0000646)	1.76150841
57	Urinary bladder sphincter dysfunction (HP:0002839)	1.75942807
58	Focal motor seizures (HP:0011153)	1.75224810
59	Abnormality of the lower motor neuron (HP:0002366)	1.73501957
60	Onion bulb formation (HP:0003383)	1.72929447
61	Flat acetabular roof (HP:0003180)	1.71860723
62	Bowel incontinence (HP:0002607)	1.69864582
63	Hyperventilation (HP:0002883)	1.68819817
64	Hypercortisolism (HP:0001578)	1.68724702
65	Long eyelashes (HP:0000527)	1.68088008
66	Spina bifida occulta (HP:0003298)	1.66307961
67	Wide anterior fontanel (HP:0000260)	1.65952412
68	Intellectual disability, severe (HP:0010864)	1.65462927
69	Dysmetric saccades (HP:0000641)	1.65161076
70	Abnormal eating behavior (HP:0100738)	1.64778495
71	Excessive salivation (HP:0003781)	1.63673234
72	Narrow nasal bridge (HP:0000446)	1.63534965
73	Aplasia/Hypoplasia of the pubic bone (HP:0009104)	1.63157219
74	Dislocated radial head (HP:0003083)	1.61700501
75	Cone-shaped epiphyses of the phalanges of the hand (HP:0010230)	1.60924003
76	Insomnia (HP:0100785)	1.60894216
77	Action tremor (HP:0002345)	1.60458749
78	Protrusio acetabuli (HP:0003179)	1.60332536
79	Renovascular hypertension (HP:0100817)	1.59686893
80	Vertebral arch anomaly (HP:0008438)	1.59491329
81	Abnormality of the radial head (HP:0003995)	1.59391808
82	Hemiplegia (HP:0002301)	1.59388676
83	Growth hormone excess (HP:0000845)	1.59058974
84	Colitis (HP:0002583)	1.58203497
85	Mitral regurgitation (HP:0001653)	1.57916493
86	Visceral angiomatosis (HP:0100761)	1.56931845
87	Obsessive-compulsive behavior (HP:0000722)	1.56747509
88	Chin dimple (HP:0010751)	1.56219106
89	High anterior hairline (HP:0009890)	1.55265102
90	Mitral valve prolapse (HP:0001634)	1.55260179
91	Eczematoid dermatitis (HP:0000976)	1.54225436
92	Abnormal hair whorl (HP:0010721)	1.54139788
93	Lymphangioma (HP:0100764)	1.53666453
94	Deeply set eye (HP:0000490)	1.53075848
95	Asymmetric growth (HP:0100555)	1.53045302
96	Hammertoe (HP:0001765)	1.52467515
97	Overgrowth (HP:0001548)	1.51125621
98	Joint laxity (HP:0001388)	1.50804223
99	Thin ribs (HP:0000883)	1.50443160
100	Sparse lateral eyebrow (HP:0005338)	1.50333155

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	TRIB3	3.46717397
2	SIK2	3.17052914
3	MARK1	3.15377317
4	MAP3K10	2.54199494
5	ICK	2.51913886
6	PRPF4B	2.49988504
7	SIK1	2.00564356
8	NTRK2	1.92828932
9	MARK2	1.81723869
10	EEF2K	1.81100651
11	PRKD3	1.80740618
12	ERN1	1.79666362
13	TYRO3	1.77163304
14	CAMKK1	1.72486338
15	CASK	1.69272809
16	RIPK1	1.64650740
17	NTRK3	1.64484149
18	FGFR4	1.54567319
19	CDK12	1.53920521
20	SMG1	1.52234171
21	UHMK1	1.45015087
22	MAP3K7	1.43762788
23	TNK2	1.40784717
24	PKN2	1.35695233
25	SGK494	1.35447785
26	SGK223	1.35447785
27	SGK2	1.29144833
28	RET	1.27425986
29	RIPK4	1.27235936
30	MAP4K1	1.26407497
31	KSR2	1.21246560
32	DYRK1B	1.19830978
33	NTRK1	1.18961755
34	EPHB1	1.18147107
35	EPHA4	1.18085841
36	PRKD2	1.17649948
37	HIPK2	1.12528667
38	SGK3	1.11043351
39	EPHA3	1.10482459
40	FGFR2	1.07199707
41	MAP3K6	1.06930168
42	CAMK1G	1.03806441
43	CAMK1D	1.03691550
44	RPS6KA2	1.01234035
45	CDC42BPA	0.99901752
46	PRKCH	0.99066105
47	EPHB2	0.92628292
48	PDGFRA	0.91310370
49	MAP2K4	0.90877197
50	FES	0.87682548
51	MAP3K13	0.87597031
52	MAPK13	0.86422968
53	BRD4	0.84112915
54	PTK6	0.82648341
55	MAPK12	0.81284748
56	FGFR3	0.80856206
57	CDK5	0.79255609
58	SIK3	0.77923683
59	MTOR	0.75884608
60	TYK2	0.73616583
61	DYRK2	0.72828815
62	TAOK1	0.72562108
63	RPS6KC1	0.71886912
64	RPS6KL1	0.71886912
65	CAMK4	0.71050347
66	PAK6	0.70803922
67	DYRK1A	0.69855162
68	GRK6	0.69667561
69	STK11	0.67151725
70	MAPK7	0.66739731
71	STK38	0.65136123
72	BTK	0.63719656
73	DAPK2	0.63088661
74	WNK1	0.60229319
75	CDK19	0.59695733
76	KSR1	0.59419276
77	MAPK15	0.59112087
78	RPS6KA6	0.59072605
79	PRKCZ	0.58980186
80	HCK	0.58634345
81	AKT3	0.58476927
82	FYN	0.55442267
83	PDGFRB	0.55244304
84	MINK1	0.53735232
85	MAP3K2	0.53179282
86	CAMK1	0.52673989
87	YES1	0.49594194
88	ZAP70	0.49503623
89	PASK	0.47711883
90	SGK1	0.47382150
91	MAPK10	0.46019282
92	ERBB2	0.44558325
93	MAP3K1	0.43772038
94	JAK2	0.43591837
95	CAMKK2	0.42956616
96	PDK1	0.42283127
97	PRKAA1	0.40609746
98	MAPK8	0.39381795
99	PDPK1	0.39087959
100	MAP3K4	0.37086763

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Notch signaling pathway_Homo sapiens_hsa04330	1.78862620
2	Endometrial cancer_Homo sapiens_hsa05213	1.63337187
3	Long-term potentiation_Homo sapiens_hsa04720	1.62729031
4	Non-small cell lung cancer_Homo sapiens_hsa05223	1.52205438
5	ErbB signaling pathway_Homo sapiens_hsa04012	1.49683853
6	Acute myeloid leukemia_Homo sapiens_hsa05221	1.49525572
7	Choline metabolism in cancer_Homo sapiens_hsa05231	1.46090826
8	Axon guidance_Homo sapiens_hsa04360	1.45724270
9	Fc epsilon RI signaling pathway_Homo sapiens_hsa04664	1.45656081
10	Vasopressin-regulated water reabsorption_Homo sapiens_hsa04962	1.43341459
11	Phospholipase D signaling pathway_Homo sapiens_hsa04072	1.43138324
12	Nicotine addiction_Homo sapiens_hsa05033	1.42895811
13	Neurotrophin signaling pathway_Homo sapiens_hsa04722	1.42304711
14	VEGF signaling pathway_Homo sapiens_hsa04370	1.41306562
15	Chronic myeloid leukemia_Homo sapiens_hsa05220	1.41060385
16	Phosphatidylinositol signaling system_Homo sapiens_hsa04070	1.41033063
17	Cholinergic synapse_Homo sapiens_hsa04725	1.40695920
18	Cocaine addiction_Homo sapiens_hsa05030	1.34464959
19	Glutamatergic synapse_Homo sapiens_hsa04724	1.33263082
20	mTOR signaling pathway_Homo sapiens_hsa04150	1.32886917
21	GnRH signaling pathway_Homo sapiens_hsa04912	1.32830609
22	Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa04961	1.31263510
23	Thyroid hormone signaling pathway_Homo sapiens_hsa04919	1.30477647
24	B cell receptor signaling pathway_Homo sapiens_hsa04662	1.28750558
25	Circadian entrainment_Homo sapiens_hsa04713	1.28288670
26	Aldosterone synthesis and secretion_Homo sapiens_hsa04925	1.28217010
27	Carbohydrate digestion and absorption_Homo sapiens_hsa04973	1.27687212
28	Colorectal cancer_Homo sapiens_hsa05210	1.27650264
29	Estrogen signaling pathway_Homo sapiens_hsa04915	1.27396103
30	Glioma_Homo sapiens_hsa05214	1.27219046
31	Retrograde endocannabinoid signaling_Homo sapiens_hsa04723	1.25818281
32	Dopaminergic synapse_Homo sapiens_hsa04728	1.23970578
33	Amphetamine addiction_Homo sapiens_hsa05031	1.22028459
34	Fc gamma R-mediated phagocytosis_Homo sapiens_hsa04666	1.21196759
35	Renal cell carcinoma_Homo sapiens_hsa05211	1.20488596
36	Type II diabetes mellitus_Homo sapiens_hsa04930	1.18973782
37	Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa04960	1.18365729
38	Prolactin signaling pathway_Homo sapiens_hsa04917	1.18042532
39	Regulation of lipolysis in adipocytes_Homo sapiens_hsa04923	1.17801925
40	Melanogenesis_Homo sapiens_hsa04916	1.12069137
41	Inositol phosphate metabolism_Homo sapiens_hsa00562	1.07423372
42	Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa04261	1.06383905
43	Morphine addiction_Homo sapiens_hsa05032	1.04719531
44	Pancreatic cancer_Homo sapiens_hsa05212	1.04401859
45	Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa04750	1.03625466
46	Longevity regulating pathway - mammal_Homo sapiens_hsa04211	1.02538999
47	Dorso-ventral axis formation_Homo sapiens_hsa04320	1.02362134
48	Long-term depression_Homo sapiens_hsa04730	1.02228599
49	Butirosin and neomycin biosynthesis_Homo sapiens_hsa00524	1.01961285
50	AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa04933	1.01788728
51	GABAergic synapse_Homo sapiens_hsa04727	1.01727889
52	Other types of O-glycan biosynthesis_Homo sapiens_hsa00514	1.01013493
53	Gap junction_Homo sapiens_hsa04540	1.00756511
54	T cell receptor signaling pathway_Homo sapiens_hsa04660	1.00510070
55	Insulin secretion_Homo sapiens_hsa04911	0.99330373
56	Gastric acid secretion_Homo sapiens_hsa04971	0.97663504
57	Insulin signaling pathway_Homo sapiens_hsa04910	0.95613938
58	Oxytocin signaling pathway_Homo sapiens_hsa04921	0.95583951
59	Rap1 signaling pathway_Homo sapiens_hsa04015	0.95544353
60	Synaptic vesicle cycle_Homo sapiens_hsa04721	0.94434127
61	AMPK signaling pathway_Homo sapiens_hsa04152	0.93392460
62	cAMP signaling pathway_Homo sapiens_hsa04024	0.89755916
63	Basal cell carcinoma_Homo sapiens_hsa05217	0.89437148
64	Renin secretion_Homo sapiens_hsa04924	0.85214742
65	Ras signaling pathway_Homo sapiens_hsa04014	0.83232248
66	Prostate cancer_Homo sapiens_hsa05215	0.83106433
67	MAPK signaling pathway_Homo sapiens_hsa04010	0.82864401
68	Chemokine signaling pathway_Homo sapiens_hsa04062	0.80623437
69	Longevity regulating pathway - multiple species_Homo sapiens_hsa04213	0.80036491
70	FoxO signaling pathway_Homo sapiens_hsa04068	0.77157856
71	Thyroid cancer_Homo sapiens_hsa05216	0.76849547
72	Sphingolipid signaling pathway_Homo sapiens_hsa04071	0.76510646
73	Chagas disease (American trypanosomiasis)_Homo sapiens_hsa05142	0.74770962
74	Osteoclast differentiation_Homo sapiens_hsa04380	0.73265062
75	cGMP-PKG signaling pathway_Homo sapiens_hsa04022	0.72131821
76	Lysine degradation_Homo sapiens_hsa00310	0.71523897
77	Leukocyte transendothelial migration_Homo sapiens_hsa04670	0.69790138
78	Wnt signaling pathway_Homo sapiens_hsa04310	0.69237638
79	Platelet activation_Homo sapiens_hsa04611	0.68006527
80	Central carbon metabolism in cancer_Homo sapiens_hsa05230	0.67134224
81	Insulin resistance_Homo sapiens_hsa04931	0.66218189
82	Salivary secretion_Homo sapiens_hsa04970	0.66042057
83	Endocytosis_Homo sapiens_hsa04144	0.65671609
84	Hepatitis C_Homo sapiens_hsa05160	0.64535940
85	Adherens junction_Homo sapiens_hsa04520	0.63835508
86	Natural killer cell mediated cytotoxicity_Homo sapiens_hsa04650	0.63776811
87	Focal adhesion_Homo sapiens_hsa04510	0.63575655
88	Bacterial invasion of epithelial cells_Homo sapiens_hsa05100	0.62398451
89	Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa00534	0.62115242
90	Cell adhesion molecules (CAMs)_Homo sapiens_hsa04514	0.61174650
91	Calcium signaling pathway_Homo sapiens_hsa04020	0.60738100
92	Vascular smooth muscle contraction_Homo sapiens_hsa04270	0.60009815
93	Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa04550	0.59263456
94	Hedgehog signaling pathway_Homo sapiens_hsa04340	0.59135027
95	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	0.57713604
96	Hepatitis B_Homo sapiens_hsa05161	0.57239376
97	Prion diseases_Homo sapiens_hsa05020	0.57136093
98	Glycerophospholipid metabolism_Homo sapiens_hsa00564	0.56745586
99	MicroRNAs in cancer_Homo sapiens_hsa05206	0.56260814
100	Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa05014	0.54111545

SLC35E2B

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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