SLC35E4

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1positive regulation of mitotic metaphase/anaphase transition (GO:0045842)9.86949248
2positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)9.86949248
3positive regulation of mitotic sister chromatid separation (GO:1901970)9.86949248
4negative regulation of Ras GTPase activity (GO:0034261)9.01619628
5eosinophil chemotaxis (GO:0048245)8.78842203
6eosinophil migration (GO:0072677)7.88817776
7L-fucose catabolic process (GO:0042355)7.43830298
8fucose catabolic process (GO:0019317)7.43830298
9L-fucose metabolic process (GO:0042354)7.43830298
10negative regulation of peptidyl-threonine phosphorylation (GO:0010801)7.42296745
11negative regulation of T cell receptor signaling pathway (GO:0050860)7.22604932
12regulation of mononuclear cell migration (GO:0071675)7.01880217
13negative regulation of retinoic acid receptor signaling pathway (GO:0048387)6.99388618
14regulation of sister chromatid cohesion (GO:0007063)6.80544543
15positive regulation of chromosome segregation (GO:0051984)6.66973721
16branch elongation of an epithelium (GO:0060602)6.42446219
17negative regulation of fibroblast growth factor receptor signaling pathway (GO:0040037)6.28402206
18regulation of retinoic acid receptor signaling pathway (GO:0048385)5.99125745
19ribosomal small subunit assembly (GO:0000028)5.99045816
20vesicle fusion (GO:0006906)5.80813883
21autophagic vacuole fusion (GO:0000046)5.55520930
22seminiferous tubule development (GO:0072520)5.49248964
23positive regulation of calcium ion import (GO:0090280)5.49182677
24negative regulation of antigen receptor-mediated signaling pathway (GO:0050858)5.41799142
25coenzyme A biosynthetic process (GO:0015937)5.13044147
26organ growth (GO:0035265)4.98348330
27peptidyl-lysine dimethylation (GO:0018027)4.94742462
28acrosome assembly (GO:0001675)4.92807124
29protein import into peroxisome matrix (GO:0016558)4.83585050
30detection of chemical stimulus involved in sensory perception of taste (GO:0050912)4.69036508
31detection of chemical stimulus involved in sensory perception of bitter taste (GO:0001580)4.52426022
32axis elongation (GO:0003401)4.50874221
33macrophage chemotaxis (GO:0048246)4.48661759
34organelle membrane fusion (GO:0090174)4.41988865
35oxidative demethylation (GO:0070989)4.34428248
36cell adhesion mediated by integrin (GO:0033627)4.19521025
37fucosylation (GO:0036065)4.16772048
38monocyte chemotaxis (GO:0002548)4.15745982
39protein localization to endosome (GO:0036010)4.13672536
40proteasome assembly (GO:0043248)4.10870113
41plasma membrane repair (GO:0001778)4.10314964
42regulation of nitric-oxide synthase biosynthetic process (GO:0051769)4.09866993
43establishment of mitotic spindle orientation (GO:0000132)4.06330591
44negative regulation of GTP catabolic process (GO:0033125)3.94930306
45negative regulation of GTPase activity (GO:0034260)3.94930306
46organelle fusion (GO:0048284)3.93583287
47regulation of T cell receptor signaling pathway (GO:0050856)3.93014317
48fucose metabolic process (GO:0006004)3.92390973
49RNA methylation (GO:0001510)3.90910962
50skin morphogenesis (GO:0043589)3.86949591
51regulation of ER to Golgi vesicle-mediated transport (GO:0060628)3.85439370
52preassembly of GPI anchor in ER membrane (GO:0016254)3.80126580
53mitochondrial RNA metabolic process (GO:0000959)3.77782330
54protein targeting to lysosome (GO:0006622)3.75567559
55establishment of protein localization to vacuole (GO:0072666)3.75567559
56protein targeting to vacuole (GO:0006623)3.75567559
57regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process (GO:23.72461949
58positive chemotaxis (GO:0050918)3.67906833
59establishment of mitotic spindle localization (GO:0040001)3.67656044
60stress fiber assembly (GO:0043149)3.66382528
61regulation of integrin-mediated signaling pathway (GO:2001044)3.65393613
62double-strand break repair via nonhomologous end joining (GO:0006303)3.63731403
63non-recombinational repair (GO:0000726)3.63731403
64regulation of fibroblast growth factor receptor signaling pathway (GO:0040036)3.60149913
65histone H3-K9 methylation (GO:0051567)3.60097642
66negative regulation of circadian rhythm (GO:0042754)3.57975300
67wound healing, spreading of epidermal cells (GO:0035313)3.55992832
68single-organism membrane fusion (GO:0044801)3.54467648
69negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)3.48291010
70regulation of early endosome to late endosome transport (GO:2000641)3.47827318
71DNA integration (GO:0015074)3.47276353
72pantothenate metabolic process (GO:0015939)3.46861411
73regulation of beta-amyloid formation (GO:1902003)3.46671178
74establishment of spindle orientation (GO:0051294)3.35553167
75tRNA modification (GO:0006400)3.30972660
76virion attachment to host cell (GO:0019062)3.26601449
77adhesion of symbiont to host cell (GO:0044650)3.26601449
78metallo-sulfur cluster assembly (GO:0031163)3.25632582
79iron-sulfur cluster assembly (GO:0016226)3.25632582
80wound healing, spreading of cells (GO:0044319)3.25402719
81regulation of calcium ion import (GO:0090279)3.17809035
82DNA demethylation (GO:0080111)3.17410396
83protein localization to peroxisome (GO:0072662)3.17151650
84protein targeting to peroxisome (GO:0006625)3.17151650
85establishment of protein localization to peroxisome (GO:0072663)3.17151650
86regulation of peptidyl-threonine phosphorylation (GO:0010799)3.16324136
87purine nucleoside bisphosphate biosynthetic process (GO:0034033)3.15109487
88ribonucleoside bisphosphate biosynthetic process (GO:0034030)3.15109487
89nucleoside bisphosphate biosynthetic process (GO:0033866)3.15109487
90regulation of autophagic vacuole assembly (GO:2000785)3.14290478
91protein sumoylation (GO:0016925)3.11764404
92lung-associated mesenchyme development (GO:0060484)3.10994189
93axon ensheathment in central nervous system (GO:0032291)3.09447302
94central nervous system myelination (GO:0022010)3.09447302
95regulation of stem cell maintenance (GO:2000036)3.07450001
96cytoskeletal anchoring at plasma membrane (GO:0007016)3.06991663
97chondrocyte proliferation (GO:0035988)3.03371063
98termination of RNA polymerase III transcription (GO:0006386)3.00747291
99transcription elongation from RNA polymerase III promoter (GO:0006385)3.00747291
100regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)2.99304113
101membrane budding (GO:0006900)2.99223179
102regulation of vascular endothelial growth factor signaling pathway (GO:1900746)2.97807394
103protein localization to lysosome (GO:0061462)2.95918401
104protein localization to vacuole (GO:0072665)2.95918401
105regulation of vacuole organization (GO:0044088)2.95618369
106peroxisomal transport (GO:0043574)2.94228813
107positive regulation of protein homooligomerization (GO:0032464)2.87315564
108intracellular protein transmembrane import (GO:0044743)2.85494437
109male meiosis I (GO:0007141)2.85427428
110RNA modification (GO:0009451)2.83557932
111coenzyme A metabolic process (GO:0015936)2.79672409
112negative regulation of dendrite morphogenesis (GO:0050774)2.78283471
113piRNA metabolic process (GO:0034587)2.78171091
114collagen fibril organization (GO:0030199)2.78169592
115Golgi transport vesicle coating (GO:0048200)2.77945584
116COPI coating of Golgi vesicle (GO:0048205)2.77945584
117membrane raft organization (GO:0031579)2.76757530
118endodermal cell differentiation (GO:0035987)2.76722992
119negative regulation of macroautophagy (GO:0016242)2.74751743
120negative regulation of purine nucleotide catabolic process (GO:0033122)2.73963088
121negative regulation of fatty acid transport (GO:2000192)2.73826946
122ER to Golgi vesicle-mediated transport (GO:0006888)2.73665807
123positive regulation of osteoblast proliferation (GO:0033690)2.73313410
124negative regulation of ryanodine-sensitive calcium-release channel activity (GO:0060315)2.70000920
125apoptotic cell clearance (GO:0043277)2.67895481
126myelin maintenance (GO:0043217)2.67482362
127long-chain fatty acid biosynthetic process (GO:0042759)2.65388824
128cortical actin cytoskeleton organization (GO:0030866)2.64535993
129protein targeting to plasma membrane (GO:0072661)2.64184461
130peptidyl-proline hydroxylation (GO:0019511)2.63833309
131lens fiber cell development (GO:0070307)2.55261159
132positive regulation of axon extension (GO:0045773)2.52684265
133dermatan sulfate biosynthetic process (GO:0030208)2.51441071
134positive regulation of vesicle fusion (GO:0031340)2.50707045
135axon ensheathment (GO:0008366)2.49271233
136ensheathment of neurons (GO:0007272)2.49271233
137protein maturation by protein folding (GO:0022417)2.45411405
138adhesion of symbiont to host (GO:0044406)2.43794814
139cerebellar Purkinje cell layer development (GO:0021680)2.42880676
140astrocyte development (GO:0014002)2.42649326
141myelination (GO:0042552)2.41994235
142epithelial cell-cell adhesion (GO:0090136)2.40658411
143L-serine transport (GO:0015825)2.40447201
144creatine metabolic process (GO:0006600)2.39733894
145hemidesmosome assembly (GO:0031581)2.35484785
146negative regulation of phosphoprotein phosphatase activity (GO:0032515)2.34658588
147negative regulation of hydrogen peroxide-induced cell death (GO:1903206)2.34636340
148regulation of transforming growth factor beta1 production (GO:0032908)2.34051574
149cortical cytoskeleton organization (GO:0030865)2.34013340
150glycosylceramide metabolic process (GO:0006677)2.33305047
151negative regulation of smooth muscle cell migration (GO:0014912)2.33100674
152dermatan sulfate metabolic process (GO:0030205)2.32263636
153protein hydroxylation (GO:0018126)2.31827362
154positive regulation of astrocyte differentiation (GO:0048711)2.30883006
155import into cell (GO:0098657)2.26967349
156amino acid import (GO:0043090)2.21058715
157sarcoplasmic reticulum calcium ion transport (GO:0070296)2.20680663
158actin filament bundle organization (GO:0061572)2.19730060
159actin filament bundle assembly (GO:0051017)2.19730060
160maintenance of protein localization in endoplasmic reticulum (GO:0035437)2.18952363
161peripheral nervous system axon ensheathment (GO:0032292)2.18948111
162myelination in peripheral nervous system (GO:0022011)2.18948111
163regulation of histone phosphorylation (GO:0033127)2.16668374
164zinc ion transmembrane transport (GO:0071577)2.15898420
165endoplasmic reticulum calcium ion homeostasis (GO:0032469)2.15052476
166L-amino acid import (GO:0043092)2.14138345
167positive regulation of mitochondrial calcium ion concentration (GO:0051561)2.11710948
168localization within membrane (GO:0051668)2.11580698
169positive regulation of potassium ion transmembrane transporter activity (GO:1901018)2.11456461
170regulation of phospholipid biosynthetic process (GO:0071071)2.11039458
171cellular response to nerve growth factor stimulus (GO:1990090)2.10094841
172response to nerve growth factor (GO:1990089)2.10094841
173synaptic vesicle maturation (GO:0016188)2.09438296
174response to lipoprotein particle (GO:0055094)2.09215516
175negative regulation of focal adhesion assembly (GO:0051895)2.08785262
176negative regulation of cell junction assembly (GO:1901889)2.08785262
177negative regulation of adherens junction organization (GO:1903392)2.08785262
178regulation of membrane protein ectodomain proteolysis (GO:0051043)2.08264409
179CDP-diacylglycerol metabolic process (GO:0046341)2.07959457
180extracellular matrix assembly (GO:0085029)2.07455761
181negative regulation of membrane potential (GO:0045837)2.07149232
182cellular response to arsenic-containing substance (GO:0071243)2.06585130
183neuron remodeling (GO:0016322)2.05787420
184serine transport (GO:0032329)2.05451945
185endocytic recycling (GO:0032456)2.05201985
186response to redox state (GO:0051775)2.05114099
187collagen catabolic process (GO:0030574)2.04480765
188actin filament depolymerization (GO:0030042)2.04447806
189cellular response to vitamin (GO:0071295)2.03967582
190regulation of monocyte chemotaxis (GO:0090025)2.03381745
191layer formation in cerebral cortex (GO:0021819)2.02382113
192positive regulation of calcium ion-dependent exocytosis (GO:0045956)2.02275942
193positive regulation of fibroblast migration (GO:0010763)2.01954003
194keratan sulfate catabolic process (GO:0042340)2.01490133
195prenylation (GO:0097354)10.1046796
196protein prenylation (GO:0018342)10.1046796
197positive regulation of membrane protein ectodomain proteolysis (GO:0051044)1.99921352
198activation of signaling protein activity involved in unfolded protein response (GO:0006987)1.99822533
199collagen metabolic process (GO:0032963)1.99555441

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse6.45456056
2GATA1_22025678_ChIP-Seq_K562_Human6.25750246
3TP63_17297297_ChIP-ChIP_HaCaT_Human6.06278791
4VDR_22108803_ChIP-Seq_LS180_Human5.72874987
5NOTCH1_21737748_ChIP-Seq_TLL_Human4.91646139
6RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse4.61202097
7TRIM28_21343339_ChIP-Seq_HEK293_Human4.61023008
8RARG_19884340_ChIP-ChIP_MEFs_Mouse4.36964088
9GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse3.72671780
10ZNF274_21170338_ChIP-Seq_K562_Hela3.56787452
11KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.02536717
12ESR2_21235772_ChIP-Seq_MCF-7_Human2.77149538
13PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse2.48879997
14TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse2.36813124
15HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.31477755
16GABP_17652178_ChIP-ChIP_JURKAT_Human2.25207127
17FLI1_27457419_Chip-Seq_LIVER_Mouse2.20066644
18GBX2_23144817_ChIP-Seq_PC3_Human2.19447860
19* TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human2.18049768
20RUNX2_24764292_ChIP-Seq_MC3T3_Mouse2.15242979
21YY1_21170310_ChIP-Seq_MESCs_Mouse2.10627844
22CEBPB_23403033_ChIP-Seq_LIVER_Mouse2.07945629
23CLOCK_20551151_ChIP-Seq_293T_Human2.01115261
24SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.98994724
25SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.98675756
26AR_21572438_ChIP-Seq_LNCaP_Human1.98086359
27ETS1_20019798_ChIP-Seq_JURKAT_Human1.96056491
28ZNF263_19887448_ChIP-Seq_K562_Human1.95040564
29ELK3_25401928_ChIP-Seq_HUVEC_Human1.91078798
30FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.87640029
31JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.86639786
32ATF3_23680149_ChIP-Seq_GBM1-GSC_Human1.84548485
33TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.83888275
34SRF_21415370_ChIP-Seq_HL-1_Mouse1.80169063
35P300_27058665_Chip-Seq_ZR-75-30cells_Human1.78603380
36ATF3_27146783_Chip-Seq_COLON_Human1.78144881
37TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.77723251
38POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.77690898
39TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.77690898
40RACK7_27058665_Chip-Seq_MCF-7_Human1.73750988
41STAT6_21828071_ChIP-Seq_BEAS2B_Human1.73540828
42ESR1_21235772_ChIP-Seq_MCF-7_Human1.70741598
43CJUN_26792858_Chip-Seq_BT549_Human1.69997310
44PCGF2_27294783_Chip-Seq_ESCs_Mouse1.69579328
45ZFP57_27257070_Chip-Seq_ESCs_Mouse1.68567223
46EZH2_22144423_ChIP-Seq_EOC_Human1.68083448
47TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.66991828
48BCAT_22108803_ChIP-Seq_LS180_Human1.66008045
49NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.63675121
50NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.62094775
51CTBP1_25329375_ChIP-Seq_LNCAP_Human1.58093826
52WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.57987862
53* JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.57060334
54CDX2_19796622_ChIP-Seq_MESCs_Mouse1.56943318
55PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse1.56808568
56SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.55497609
57SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.55497609
58MTF2_20144788_ChIP-Seq_MESCs_Mouse1.55112708
59KDM2B_26808549_Chip-Seq_K562_Human1.52015221
60* SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.52006587
61TAF15_26573619_Chip-Seq_HEK293_Human1.51390018
62UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.50343175
63NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.46212623
64HIF1A_21447827_ChIP-Seq_MCF-7_Human1.45635655
65SOX2_20726797_ChIP-Seq_SW620_Human1.45144871
66NR3C1_21868756_ChIP-Seq_MCF10A_Human1.43744716
67PPAR_26484153_Chip-Seq_NCI-H1993_Human1.42842588
68IRF1_19129219_ChIP-ChIP_H3396_Human1.41824584
69* JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.41297610
70ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.40780711
71NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.40674404
72NRF2_20460467_ChIP-Seq_MEFs_Mouse1.40674404
73KDM2B_26808549_Chip-Seq_SUP-B15_Human1.40304132
74LXR_22292898_ChIP-Seq_THP-1_Human1.39987757
75CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.39390239
76P63_26484246_Chip-Seq_KERATINOCYTES_Human1.39307430
77SRY_22984422_ChIP-ChIP_TESTIS_Rat1.38119030
78CTBP2_25329375_ChIP-Seq_LNCAP_Human1.37574091
79* SMC1_22415368_ChIP-Seq_MEFs_Mouse1.37076225
80EZH2_18974828_ChIP-Seq_MESCs_Mouse1.34922254
81RNF2_18974828_ChIP-Seq_MESCs_Mouse1.34922254
82KLF5_25053715_ChIP-Seq_YYC3_Human1.33018096
83UBF1/2_26484160_Chip-Seq_HMECs_Human1.32815761
84FOXO3_23340844_ChIP-Seq_DLD1_Human1.30040955
85* TP53_23651856_ChIP-Seq_MEFs_Mouse1.29729234
86P300_19829295_ChIP-Seq_ESCs_Human1.29005128
87SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.28541056
88TET1_21490601_ChIP-Seq_MESCs_Mouse1.27462551
89* TP53_22127205_ChIP-Seq_IMR90_Human1.26584867
90* GATA2_21666600_ChIP-Seq_HMVEC_Human1.26508952
91NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.26381655
92* ZFP281_18757296_ChIP-ChIP_E14_Mouse1.26368450
93KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.25286790
94KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.25286790
95KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.25286790
96SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.24646463
97ERG_21242973_ChIP-ChIP_JURKAT_Human1.23893764
98SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.22791126
99* TP53_22573176_ChIP-Seq_HFKS_Human1.22182116
100EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.21917513
101KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.20327683
102JARID2_20075857_ChIP-Seq_MESCs_Mouse1.19815244
103P53_22127205_ChIP-Seq_FIBROBLAST_Human1.19278718
104RXR_22108803_ChIP-Seq_LS180_Human1.18227477
105CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.17142721
106CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.16896486
107HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.16105946
108EOMES_21245162_ChIP-Seq_HESCs_Human1.15579372
109SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.15211162
110* TP53_20018659_ChIP-ChIP_R1E_Mouse1.14932850
111TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.14687160
112KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.14037555
113ELK1_22589737_ChIP-Seq_MCF10A_Human1.13896431
114* EZH2_27294783_Chip-Seq_ESCs_Mouse1.12474618
115EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.10942932
116* SMC3_22415368_ChIP-Seq_MEFs_Mouse1.10550934
117KLF5_20875108_ChIP-Seq_MESCs_Mouse1.10208766
118FUS_26573619_Chip-Seq_HEK293_Human1.09343236
119MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.09003430
120EOMES_20176728_ChIP-ChIP_TSCs_Mouse1.08696108
121KDM2B_26808549_Chip-Seq_DND41_Human1.08221763
122IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.07681686
123CBP_20019798_ChIP-Seq_JUKART_Human1.07681686
124* RNF2_27304074_Chip-Seq_ESCs_Mouse1.04406304
125TP53_16413492_ChIP-PET_HCT116_Human1.04294003
126* SUZ12_27294783_Chip-Seq_ESCs_Mouse1.04274198
127* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.04226383
128EP300_21415370_ChIP-Seq_HL-1_Mouse1.03932929
129RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.03834902
130ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.03487251
131NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.03417259
132* CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.03263481
133Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.03223750
134FOXP2_23625967_ChIP-Seq_PFSK-1_AND_SK-N-MC_Human1.02602404
135SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.02415812
136SALL4_18804426_ChIP-ChIP_XEN_Mouse1.01839351
137CEBPA_26348894_ChIP-Seq_LIVER_Mouse1.01249467
138THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.00897246
139VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.00734916
140UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.00534308
141EED_16625203_ChIP-ChIP_MESCs_Mouse1.00049623
142NR3C1_23031785_ChIP-Seq_PC12_Mouse0.99812847
143SMAD_19615063_ChIP-ChIP_OVARY_Human0.98938321
144RUNX1_27514584_Chip-Seq_MCF-7_Human0.97225884
145MYCN_21190229_ChIP-Seq_SHEP-21N_Human0.96943398
146DNAJC2_21179169_ChIP-ChIP_NT2_Human0.96189108
147RNF2_27304074_Chip-Seq_NSC_Mouse0.96150642
148JARID2_20064375_ChIP-Seq_MESCs_Mouse0.95439106
149PPARD_23208498_ChIP-Seq_MDA-MB-231_Human0.95268698
150EZH2_27304074_Chip-Seq_ESCs_Mouse0.95268430
151REST_18959480_ChIP-ChIP_MESCs_Mouse0.95043979
152KLF4_18358816_ChIP-ChIP_MESCs_Mouse0.94044712
153SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.93772520
154SOX2_19829295_ChIP-Seq_ESCs_Human0.92705958
155NANOG_19829295_ChIP-Seq_ESCs_Human0.92705958
156SUZ12_27294783_Chip-Seq_NPCs_Mouse0.91879767
157VDR_23849224_ChIP-Seq_CD4+_Human0.90818790
158NCOR_22424771_ChIP-Seq_293T_Human0.90037763
159NR4A2_19515692_ChIP-ChIP_MN9D_Mouse0.89639907
160HTT_18923047_ChIP-ChIP_STHdh_Human0.89566899
161FOXA1_25329375_ChIP-Seq_VCAP_Human0.89066982
162FOXA1_27270436_Chip-Seq_PROSTATE_Human0.89066982
163STAT1_20625510_ChIP-Seq_HELA_Human0.88965408
164PCGF2_27294783_Chip-Seq_NPCs_Mouse0.88609079
165FOXH1_21741376_ChIP-Seq_EPCs_Human0.88466940
166GATA3_26560356_Chip-Seq_TH1_Human0.88175142
167CBX2_27304074_Chip-Seq_ESCs_Mouse0.85399099
168TCF4_22108803_ChIP-Seq_LS180_Human0.84944930
169EST1_17652178_ChIP-ChIP_JURKAT_Human0.84794069
170BMI1_23680149_ChIP-Seq_NPCS_Mouse0.84142310
171NANOG_20526341_ChIP-Seq_ESCs_Human0.83322945
172CEBPD_23245923_ChIP-Seq_MEFs_Mouse0.82967049
173THAP11_20581084_ChIP-Seq_MESCs_Mouse0.82734004
174GATA3_21878914_ChIP-Seq_MCF-7_Human0.82517050
175PIAS1_25552417_ChIP-Seq_VCAP_Human0.82404706
176POU5F1_18358816_ChIP-ChIP_MESCs_Mouse0.82383557
177FOXH1_21741376_ChIP-Seq_ESCs_Human0.82038294
178REST_21632747_ChIP-Seq_MESCs_Mouse0.81665952
179WDR5_24793694_ChIP-Seq_LNCAP_Human0.80944476
180GABP_19822575_ChIP-Seq_HepG2_Human0.80531540
181SMAD2/3_21741376_ChIP-Seq_EPCs_Human0.80361959
182SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.80236588
183EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human0.80184948
184NFE2_27457419_Chip-Seq_LIVER_Mouse0.79219245
185SMAD4_21799915_ChIP-Seq_A2780_Human0.78395308
186VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human0.76201794
187OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.75755402
188MYC_19829295_ChIP-Seq_ESCs_Human0.73525460
189TBX3_20139965_ChIP-Seq_ESCs_Mouse0.73296932
190TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.72925756
191TBX3_20139965_ChIP-Seq_MESCs_Mouse0.72816784
192ETV2_25802403_ChIP-Seq_MESCs_Mouse0.71977508
193P53_21459846_ChIP-Seq_SAOS-2_Human0.71639415

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0000566_synostosis9.90328233
2MP0008438_abnormal_cutaneous_collagen4.19899735
3MP0006082_CNS_inflammation3.81593172
4MP0001986_abnormal_taste_sensitivity3.23876246
5MP0003329_amyloid_beta_deposits3.01623769
6MP0001919_abnormal_reproductive_system3.00877834
7MP0005275_abnormal_skin_tensile2.79922470
8MP0000467_abnormal_esophagus_morphology2.77629723
9MP0005623_abnormal_meninges_morphology2.74150967
10MP0002751_abnormal_autonomic_nervous2.72866259
11MP0003705_abnormal_hypodermis_morpholog2.68243688
12MP0001664_abnormal_digestion2.61880426
13MP0003279_aneurysm2.60549518
14MP0003646_muscle_fatigue2.54753178
15MP0005058_abnormal_lysosome_morphology2.46087969
16MP0001958_emphysema2.37970968
17MP0000013_abnormal_adipose_tissue2.30940192
18MP0001663_abnormal_digestive_system2.30787665
19MP0000750_abnormal_muscle_regeneration2.28146826
20MP0004270_analgesia2.24364604
21MP0005389_reproductive_system_phenotype2.22693004
22MP0001299_abnormal_eye_distance/2.22001960
23MP0003950_abnormal_plasma_membrane2.21534442
24MP0000751_myopathy2.16890959
25MP0000383_abnormal_hair_follicle2.14605651
26MP0000747_muscle_weakness2.09879299
27MP0003091_abnormal_cell_migration2.08320852
28MP0004858_abnormal_nervous_system2.07038812
29MP0002876_abnormal_thyroid_physiology2.04285415
30MP0005423_abnormal_somatic_nervous2.03399929
31MP0000749_muscle_degeneration2.02817062
32MP0000733_abnormal_muscle_development2.00370669
33MP0003566_abnormal_cell_adhesion1.97345137
34MP0002877_abnormal_melanocyte_morpholog1.92622864
35MP0000604_amyloidosis1.85508701
36MP0005257_abnormal_intraocular_pressure1.85335714
37MP0001542_abnormal_bone_strength1.85092656
38MP0009840_abnormal_foam_cell1.82754001
39MP0005381_digestive/alimentary_phenotyp1.82296542
40MP0004859_abnormal_synaptic_plasticity1.74032417
41MP0009780_abnormal_chondrocyte_physiolo1.71963856
42MP0003115_abnormal_respiratory_system1.68994249
43MP0002295_abnormal_pulmonary_circulatio1.68664546
44MP0003634_abnormal_glial_cell1.65649505
45MP0006292_abnormal_olfactory_placode1.65581154
46MP0004272_abnormal_basement_membrane1.64739358
47MP0000920_abnormal_myelination1.60441809
48MP0005410_abnormal_fertilization1.57636830
49MP0008260_abnormal_autophagy1.57107312
50MP0003937_abnormal_limbs/digits/tail_de1.57033674
51MP0005503_abnormal_tendon_morphology1.48027660
52MP0003718_maternal_effect1.41229217
53MP0002735_abnormal_chemical_nociception1.33920094
54MP0004145_abnormal_muscle_electrophysio1.33047622
55MP0003303_peritoneal_inflammation1.31600691
56MP0003136_yellow_coat_color1.31385610
57MP0005508_abnormal_skeleton_morphology1.28430511
58MP0000026_abnormal_inner_ear1.28225803
59MP0005023_abnormal_wound_healing1.26823039
60MP0005171_absent_coat_pigmentation1.26318960
61MP0000759_abnormal_skeletal_muscle1.25990728
62MP0000372_irregular_coat_pigmentation1.25761728
63MP0001293_anophthalmia1.21078117
64MP0000358_abnormal_cell_content/1.20275345
65MP0001348_abnormal_lacrimal_gland1.19263152
66MP0001968_abnormal_touch/_nociception1.18256245
67MP0010030_abnormal_orbit_morphology1.17210098
68MP0002896_abnormal_bone_mineralization1.16762615
69MP0003283_abnormal_digestive_organ1.16643228
70MP0002210_abnormal_sex_determination1.15218168
71MP0008058_abnormal_DNA_repair1.14827567
72MP0003183_abnormal_peptide_metabolism1.13881391
73MP0005501_abnormal_skin_physiology1.13112986
74MP0004087_abnormal_muscle_fiber1.12671599
75MP0003690_abnormal_glial_cell1.12382930
76MP0000534_abnormal_ureter_morphology1.12293907
77MP0009384_cardiac_valve_regurgitation1.12092490
78MP0002734_abnormal_mechanical_nocicepti1.11892473
79MP0001963_abnormal_hearing_physiology1.11366672
80MP0005551_abnormal_eye_electrophysiolog1.10396133
81MP0001286_abnormal_eye_development1.08893162
82MP0003195_calcinosis1.06261366
83MP0001545_abnormal_hematopoietic_system1.05912960
84MP0005397_hematopoietic_system_phenotyp1.05912960
85MP0005253_abnormal_eye_physiology1.05378959
86MP0002796_impaired_skin_barrier1.04803194
87MP0000003_abnormal_adipose_tissue1.04384592
88MP0010352_gastrointestinal_tract_polyps1.03598185
89MP0002102_abnormal_ear_morphology1.03561958
90MP0002106_abnormal_muscle_physiology1.00814431
91MP0002837_dystrophic_cardiac_calcinosis0.99355865
92MP0003075_altered_response_to0.99088720
93MP0004233_abnormal_muscle_weight0.99069976
94MP0002060_abnormal_skin_morphology0.98818498
95MP0005166_decreased_susceptibility_to0.98726037
96MP0001533_abnormal_skeleton_physiology0.98254400
97MP0002269_muscular_atrophy0.97753730
98MP0002736_abnormal_nociception_after0.97650235
99MP0002184_abnormal_innervation0.97632074
100MP0004885_abnormal_endolymph0.96369963
101MP0003172_abnormal_lysosome_physiology0.96227494
102MP0001243_abnormal_dermal_layer0.93392760
103MP0002998_abnormal_bone_remodeling0.93037822
104MP0005390_skeleton_phenotype0.92561615
105MP0002733_abnormal_thermal_nociception0.91937586
106MP0001929_abnormal_gametogenesis0.90888848
107MP0005369_muscle_phenotype0.90871790
108MP0000647_abnormal_sebaceous_gland0.89004357
109MP0002909_abnormal_adrenal_gland0.88256784
110MP0001905_abnormal_dopamine_level0.87785608
111MP0001970_abnormal_pain_threshold0.87553566
112MP0000049_abnormal_middle_ear0.86558328
113MP0001764_abnormal_homeostasis0.83375988
114MP0003453_abnormal_keratinocyte_physiol0.83328144
115MP0002332_abnormal_exercise_endurance0.82783057
116MP0003045_fibrosis0.81740586
117MP0006072_abnormal_retinal_apoptosis0.80881744
118MP0006276_abnormal_autonomic_nervous0.80429105
119MP0003632_abnormal_nervous_system0.80389180
120MP0005595_abnormal_vascular_smooth0.80362565
121MP0002160_abnormal_reproductive_system0.80111620
122MP0003635_abnormal_synaptic_transmissio0.79346129
123MP0004036_abnormal_muscle_relaxation0.78300273
124MP0005620_abnormal_muscle_contractility0.77705250
125MP0004084_abnormal_cardiac_muscle0.77179630
126MP0001915_intracranial_hemorrhage0.77147035
127MP0000462_abnormal_digestive_system0.76234802
128MP0000537_abnormal_urethra_morphology0.75781690
129MP0002277_abnormal_respiratory_mucosa0.75723718
130MP0003448_altered_tumor_morphology0.75612691
131MP0002163_abnormal_gland_morphology0.74968299
132MP0002064_seizures0.74924256
133MP0000767_abnormal_smooth_muscle0.74242571
134MP0000470_abnormal_stomach_morphology0.74131546
135MP0001849_ear_inflammation0.73999413
136MP0009745_abnormal_behavioral_response0.73984418
137MP0009250_abnormal_appendicular_skeleto0.73734897
138MP0002109_abnormal_limb_morphology0.73701840
139MP0002108_abnormal_muscle_morphology0.73127041
140MP0004185_abnormal_adipocyte_glucose0.72650380
141MP0002653_abnormal_ependyma_morphology0.72565461
142MP0005645_abnormal_hypothalamus_physiol0.72553571
143MP0002933_joint_inflammation0.72258186
144MP0009046_muscle_twitch0.72082340
145MP0004510_myositis0.71619927
146MP0000490_abnormal_crypts_of0.71512823
147MP0010368_abnormal_lymphatic_system0.71005753
148MP0002090_abnormal_vision0.70552366
149MP0002752_abnormal_somatic_nervous0.69942998
150MP0004947_skin_inflammation0.69906127
151MP0010678_abnormal_skin_adnexa0.69865845
152MP0002972_abnormal_cardiac_muscle0.69694411
153MP0001440_abnormal_grooming_behavior0.69444809
154MP0002254_reproductive_system_inflammat0.68902610
155MP0005164_abnormal_response_to0.68821486
156MP0008877_abnormal_DNA_methylation0.68413153
157MP0005197_abnormal_uvea_morphology0.68346357
158MP0005330_cardiomyopathy0.68316341
159MP0002234_abnormal_pharynx_morphology0.68192922
160MP0000428_abnormal_craniofacial_morphol0.67366687
161MP0003698_abnormal_male_reproductive0.67061832
162MP0000163_abnormal_cartilage_morphology0.67043709
163MP0001529_abnormal_vocalization0.66993870
164MP0010386_abnormal_urinary_bladder0.66322422
165MP0002938_white_spotting0.64697064
166MP0005391_vision/eye_phenotype0.64109311
167MP0003935_abnormal_craniofacial_develop0.63162321
168MP0005395_other_phenotype0.62814741
169MP0005195_abnormal_posterior_eye0.62450543
170MP0008875_abnormal_xenobiotic_pharmacok0.62362674
171MP0002161_abnormal_fertility/fecundity0.62034286
172MP0002115_abnormal_skeleton_extremities0.61940587
173MP0002822_catalepsy0.60263956
174MP0002127_abnormal_cardiovascular_syste0.57654942
175MP0001188_hyperpigmentation0.56938020
176MP0003942_abnormal_urinary_system0.56847077
177MP0005379_endocrine/exocrine_gland_phen0.56436091
178MP0003936_abnormal_reproductive_system0.56364109
179MP0001485_abnormal_pinna_reflex0.56051760
180MP0004043_abnormal_pH_regulation0.54855493
181MP0000653_abnormal_sex_gland0.52717723
182MP0001486_abnormal_startle_reflex0.52128620

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of long-chain fatty-acid metabolism (HP:0010964)7.80074007
2Duplicated collecting system (HP:0000081)7.00903921
3Abnormality of the renal collecting system (HP:0004742)6.41640843
4Long foot (HP:0001833)6.40642194
5Large for gestational age (HP:0001520)6.16824256
6Premature rupture of membranes (HP:0001788)5.68548951
7Progressive muscle weakness (HP:0003323)5.58890321
8Adactyly (HP:0009776)5.41396263
9Ureteral duplication (HP:0000073)5.28584335
10Acute lymphatic leukemia (HP:0006721)4.72930364
11Severe muscular hypotonia (HP:0006829)4.54287406
12Hypoplastic pelvis (HP:0008839)4.23565997
13Pulmonary artery stenosis (HP:0004415)4.20385275
14Dry hair (HP:0011359)4.19923839
15Abnormality of fatty-acid metabolism (HP:0004359)4.03762479
16Autoamputation (HP:0001218)3.91946894
17Protrusio acetabuli (HP:0003179)3.80628844
18Anhidrosis (HP:0000970)3.72912427
19Broad-based gait (HP:0002136)3.71424465
20Brushfield spots (HP:0001088)3.66806908
21Muscle fiber splitting (HP:0003555)3.59809285
22Hypoplastic nipples (HP:0002557)3.52480799
23Increased number of teeth (HP:0011069)3.46824290
24Difficulty climbing stairs (HP:0003551)3.40817082
25Steatorrhea (HP:0002570)3.32466920
26Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)3.28057735
27Transposition of the great arteries (HP:0001669)3.23607687
28Abnormal connection of the cardiac segments (HP:0011545)3.23607687
29Abnormal ventriculo-arterial connection (HP:0011563)3.23607687
30Abnormality of glycolipid metabolism (HP:0010969)3.20810122
31Abnormality of liposaccharide metabolism (HP:0010968)3.20810122
32Abnormality of glycosphingolipid metabolism (HP:0004343)3.20810122
33Neurofibrillary tangles (HP:0002185)3.16106696
34Generalized amyotrophy (HP:0003700)3.14251412
35Muscle fiber inclusion bodies (HP:0100299)3.13920783
36Shallow orbits (HP:0000586)3.05106058
37Reduced subcutaneous adipose tissue (HP:0003758)2.96916901
38Nemaline bodies (HP:0003798)2.93132369
39Short nail (HP:0001799)2.93126939
40Polymicrogyria (HP:0002126)2.92655144
41Increased connective tissue (HP:0009025)2.88082426
42Congenital stationary night blindness (HP:0007642)2.85118221
43Type 1 muscle fiber predominance (HP:0003803)2.82355970
44Ureteral stenosis (HP:0000071)2.82013447
45Spinal rigidity (HP:0003306)2.81515473
46Increased cerebral lipofuscin (HP:0011813)2.81336364
47Abnormal auditory evoked potentials (HP:0006958)2.80520510
48Supranuclear gaze palsy (HP:0000605)2.78472812
49Cerebral inclusion bodies (HP:0100314)2.77889642
50Vertebral compression fractures (HP:0002953)2.68973176
51Difficulty running (HP:0009046)2.65672496
52Round ear (HP:0100830)2.64951637
53Upper limb amyotrophy (HP:0009129)2.62819730
54Distal upper limb amyotrophy (HP:0007149)2.62819730
55Palmoplantar hyperkeratosis (HP:0000972)2.62678248
56Pterygium (HP:0001059)2.62046234
57Distal arthrogryposis (HP:0005684)2.60936712
58Ureteral obstruction (HP:0006000)2.58601927
59Dysostosis multiplex (HP:0000943)2.58212124
60Aplasia involving bones of the upper limbs (HP:0009823)2.57559476
61Aplasia of the phalanges of the hand (HP:0009802)2.57559476
62Aplasia involving bones of the extremities (HP:0009825)2.57559476
63Dynein arm defect of respiratory motile cilia (HP:0012255)2.56442854
64Absent/shortened dynein arms (HP:0200106)2.56442854
65Atrophic scars (HP:0001075)2.52773599
66Cervical subluxation (HP:0003308)2.49964366
67J-shaped sella turcica (HP:0002680)2.49903355
68Cerebral aneurysm (HP:0004944)2.49636564
69Palmar hyperkeratosis (HP:0010765)2.49351220
70Widely spaced teeth (HP:0000687)2.48777470
71Calcaneovalgus deformity (HP:0001848)2.45450465
72Chorioretinal coloboma (HP:0000567)2.44793258
73Deformed tarsal bones (HP:0008119)2.44676472
74Abnormality of the umbilical cord (HP:0010881)2.44531335
75Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)2.41728822
76Scapular winging (HP:0003691)2.39294343
77Gowers sign (HP:0003391)2.38548317
78Lactic acidosis (HP:0003128)2.37970657
79Fat malabsorption (HP:0002630)2.37836454
80Flat face (HP:0012368)2.37243305
81Abnormality of midbrain morphology (HP:0002418)2.37186705
82Molar tooth sign on MRI (HP:0002419)2.37186705
83Decreased lacrimation (HP:0000633)2.37174855
84Double outlet right ventricle (HP:0001719)2.34910501
85Congenital malformation of the right heart (HP:0011723)2.34910501
86Achilles tendon contracture (HP:0001771)2.34041589
87Increased neuronal autofluorescent lipopigment (HP:0002074)2.31568745
88Myopathic facies (HP:0002058)2.31526339
89Decreased muscle mass (HP:0003199)2.30995762
90Menstrual irregularities (HP:0000858)2.30214778
91Soft skin (HP:0000977)2.30194194
92Increased variability in muscle fiber diameter (HP:0003557)2.29651189
93Distal lower limb amyotrophy (HP:0008944)2.28436292
94Vascular tortuosity (HP:0004948)2.27894210
95Sudden death (HP:0001699)2.27168230
96Axonal loss (HP:0003447)2.26202513
97Hyporeflexia of lower limbs (HP:0002600)2.24971254
98Peritonitis (HP:0002586)2.24612506
99Thoracolumbar scoliosis (HP:0002944)2.24405024
100Wormian bones (HP:0002645)2.24304586
101Abnormality of the calcaneus (HP:0008364)2.23881251
102EMG: myopathic abnormalities (HP:0003458)2.23293582
103Ankle contracture (HP:0006466)2.23082893
104Abnormality of skeletal muscle fiber size (HP:0012084)2.22435931
105Dilatation of the ascending aorta (HP:0005111)2.19813987
106Type II lissencephaly (HP:0007260)2.19019212
107Arterial tortuosity (HP:0005116)2.18666448
108Polyneuropathy (HP:0001271)2.18093309
109Aortic dissection (HP:0002647)2.16830605
110Abnormal rod and cone electroretinograms (HP:0008323)2.15465603
111Fragile skin (HP:0001030)2.15399093
112Abnormal ciliary motility (HP:0012262)2.10453552
113Abnormality of dentin (HP:0010299)2.09089362
114Clubbing of toes (HP:0100760)2.08914658
115Mildly elevated creatine phosphokinase (HP:0008180)2.08290158
116Abnormality of the odontoid process (HP:0003310)2.07319274
117Abnormal respiratory epithelium morphology (HP:0012253)2.07134217
118Abnormal respiratory motile cilium morphology (HP:0005938)2.07134217
119Akinesia (HP:0002304)2.05203992
120Abnormality of vision evoked potentials (HP:0000649)2.03670318
121Increased serum lactate (HP:0002151)2.03088685
122Flat acetabular roof (HP:0003180)2.02652045
123Wide intermamillary distance (HP:0006610)2.02521053
124Bronchomalacia (HP:0002780)2.02022506
125Beaking of vertebral bodies (HP:0004568)2.01407687
126Plantar hyperkeratosis (HP:0007556)2.00498039
127Male infertility (HP:0003251)1.99840958
128Hypoplasia of the odontoid process (HP:0003311)1.99210205
129Osteolytic defects of the hand bones (HP:0009699)1.97922651
130Osteolytic defects of the phalanges of the hand (HP:0009771)1.97922651
131Wrist flexion contracture (HP:0001239)1.97441192
132Spastic tetraplegia (HP:0002510)1.94695586
133Lower limb amyotrophy (HP:0007210)1.94392207
134Hypoplastic iliac wings (HP:0002866)1.94161495
135Pendular nystagmus (HP:0012043)1.93606320
136Broad nasal tip (HP:0000455)1.93555598
137Absent rod-and cone-mediated responses on ERG (HP:0007688)1.92994695
138True hermaphroditism (HP:0010459)1.92582857
139Mucopolysacchariduria (HP:0008155)1.91649730
140Urinary glycosaminoglycan excretion (HP:0003541)1.91649730
141Rhabdomyolysis (HP:0003201)1.90694340
142Congenital nonbullous ichthyosiform erythroderma (HP:0007479)1.90648544
143Rapidly progressive (HP:0003678)1.90450034
144Ulnar deviation of the wrist (HP:0003049)1.88228633
145Female pseudohermaphroditism (HP:0010458)1.85234656
146Abnormality of the Achilles tendon (HP:0005109)1.84316213
147Ulnar bowing (HP:0003031)1.84134672
148Aplasia/Hypoplasia of the nipples (HP:0006709)1.83286468
149Limb dystonia (HP:0002451)1.83175418
150Myoglobinuria (HP:0002913)1.82982755
151Overfolded helix (HP:0000396)1.82076148
152Megalencephaly (HP:0001355)1.81511764
153Concave nail (HP:0001598)1.80448021
154Protuberant abdomen (HP:0001538)1.80152052
155Pancreatic cysts (HP:0001737)1.79939160
156Microretrognathia (HP:0000308)1.79830155
157Cerebral hypomyelination (HP:0006808)1.78856414
158Fetal akinesia sequence (HP:0001989)1.78827259
159Infantile muscular hypotonia (HP:0008947)1.78723906
160Fused cervical vertebrae (HP:0002949)1.78717404
161Genu recurvatum (HP:0002816)1.78377162
162Steppage gait (HP:0003376)1.78173738
163Epiphyseal stippling (HP:0010655)1.77664411
164Centrally nucleated skeletal muscle fibers (HP:0003687)1.77279147
165Coxa vara (HP:0002812)1.76454371
166Neck muscle weakness (HP:0000467)1.76010878
1673-Methylglutaconic aciduria (HP:0003535)1.75833750
168Abnormally folded helix (HP:0008544)1.74640477
169Hand muscle atrophy (HP:0009130)1.73629763
170Buphthalmos (HP:0000557)1.73587437
171Medial flaring of the eyebrow (HP:0010747)1.73412454
172Broad metatarsal (HP:0001783)1.73237758
173Pancreatic fibrosis (HP:0100732)1.72891980
174Increased CSF lactate (HP:0002490)1.72839386
175Peripheral hypomyelination (HP:0007182)1.72716435
176Shoulder girdle muscle weakness (HP:0003547)1.72570648
177Decreased central vision (HP:0007663)1.72171408
178Exercise intolerance (HP:0003546)1.71308206
179Nephronophthisis (HP:0000090)1.71172899
180Absent toe (HP:0010760)1.70892644
181Slender build (HP:0001533)1.69879681
182Anxiety (HP:0000739)1.69764748
183Follicular hyperkeratosis (HP:0007502)1.69677833
184Abnormality of the hip-girdle musculature (HP:0001445)1.69372885
185Abnormality of the musculature of the pelvis (HP:0001469)1.69372885
186Attenuation of retinal blood vessels (HP:0007843)1.69357348
187Abnormality of mucopolysaccharide metabolism (HP:0011020)1.69346542
188Abnormality of glycosaminoglycan metabolism (HP:0004371)1.69346542
189Abnormal respiratory motile cilium physiology (HP:0012261)1.67949570
190Severe visual impairment (HP:0001141)1.66395198
191Large hands (HP:0001176)1.65591481
192Aplasia/hypoplasia of the uterus (HP:0008684)1.64758199
193Congenital onset (HP:0003577)1.64109237
194Patent foramen ovale (HP:0001655)1.64013591
195Acute necrotizing encephalopathy (HP:0006965)1.61904595
196Abnormality of the line of Schwalbe (HP:0008048)1.59874988
197Scrotal hypoplasia (HP:0000046)1.59548816
198External ear malformation (HP:0008572)1.59487985
199Aplasia/Hypoplasia of the fovea (HP:0008060)1.59239468
200Hypoplasia of the fovea (HP:0007750)1.59239468

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MKNK16.06785799
2TAOK25.09623236
3EPHA24.03431421
4TRIB33.77953889
5TTN3.42729747
6MAP2K33.40890290
7NTRK12.99999077
8LIMK12.74836329
9DDR22.58831778
10PRKD32.46797787
11MOS2.32796264
12MAP3K92.27374638
13LATS22.11817471
14PAK62.05478874
15JAK32.02846318
16MKNK210.5545126
17EPHB11.84796458
18ARAF1.82320286
19MUSK1.79717436
20KSR21.76577203
21MET1.61109073
22DYRK1A1.59981164
23CAMKK21.59757867
24SCYL21.53977734
25MAP3K31.48794317
26PIM21.42954815
27TESK11.42907335
28NME21.39748875
29PTK21.39293105
30FER1.37123194
31PAK31.35380651
32BMX1.35231559
33MAP3K51.33522707
34TESK21.30393044
35RIPK11.28956841
36MAPKAPK51.28109220
37ILK1.26953481
38MAP2K11.26686917
39SRPK11.25369457
40CAMK2D1.21448127
41PTK2B1.20347876
42NME11.20318011
43ERN11.17974200
44PHKG11.17393227
45PHKG21.17393227
46PAK21.16282987
47MARK11.15205129
48ROCK21.13324603
49PDGFRA1.12327926
50CAMKK11.11963909
51CDK141.11562402
52LRRK21.08894985
53TRPM71.07835663
54STK161.07610866
55STK391.06749742
56ABL21.03515637
57DAPK30.99016955
58TIE10.98951724
59BUB10.94793789
60CHEK20.94247150
61ADRBK20.93453888
62WNK30.93234063
63MAP3K20.92770425
64MAPKAPK30.91192216
65MAP3K110.90432895
66DMPK0.90399675
67CDK150.89595610
68PAK10.88371625
69FRK0.87237578
70PIK3CG0.86226471
71PTK60.86020069
72CDK180.80670537
73FGR0.78499362
74PNCK0.77058588
75RET0.76297177
76ALK0.73883725
77IRAK20.73190830
78CDK11A0.73120251
79CAMK2B0.72916285
80MINK10.72193894
81CSNK1G30.71805806
82INSRR0.71487656
83PINK10.71249466
84EPHB20.71179410
85CAMK2G0.70540984
86OXSR10.69169620
87MAP4K20.68756229
88CSNK1G20.68171159
89FGFR20.67312229
90PKN10.65816194
91IRAK10.64922077
92PAK40.64548694
93MAP2K20.62641151
94CDK50.62586111
95ROCK10.62061880
96CSNK1A1L0.61702237
97MAPK130.61420941
98PRKCE0.59003966
99MAP3K10.58248810
100PRKD10.57509371
101GRK10.55938809
102TAOK10.53033345
103NEK90.52314032
104MAP3K40.52199508
105MAP2K70.50899115
106BCR0.50455497
107PRKCH0.49587895
108TAOK30.49170526
109IRAK30.48375318
110PBK0.47946333
111CASK0.47555090
112PDPK10.46657241
113CAMK2A0.46399796
114OBSCN0.46303873
115MAP3K80.45637282
116TRIM280.45623035
117TYRO30.44162006
118PKN20.43993650
119EEF2K0.43891790
120PRKCQ0.43445292
121PRKD20.42469983
122ZAK0.42117232
123RPS6KA40.41805060
124PDGFRB0.40204656
125ERBB40.39222302
126NUAK10.38308971
127BMPR1B0.36965299
128PLK20.36780721
129TNIK0.35844681
130LMTK20.35592885
131BRSK20.35269687
132PDK20.35158263
133WNK40.34481606
134MTOR0.33990984
135MAPKAPK20.32535566
136NTRK20.32049535
137EPHA40.30159601
138CSNK1A10.27211973
139DYRK20.27081109
140BCKDK0.26296786
141AURKA0.22446308
142ABL10.20318021
143BRSK10.18406801
144MAPK150.17677565
145VRK10.17061459
146ADRBK10.16574374
147TLK10.16137393
148PLK40.15918009
149GRK70.15509066
150PLK10.15154558
151PRKCG0.14795279
152DYRK30.14717103
153CSNK1G10.13898602
154PLK30.13771319
155GSK3A0.12088321
156CSNK2A10.11713276
157IGF1R0.10250239
158ERBB30.10167590
159PRKACA0.08024436
160PRKG20.07311774
161PRKCD0.06483310
162MAP2K40.05838369
163CSNK1E0.05703630

Predicted pathways (KEGG)

RankGene SetZ-score
1Pantothenate and CoA biosynthesis_Homo sapiens_hsa007704.29896418
2RNA polymerase_Homo sapiens_hsa030204.10448140
3Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005633.58237104
4Taste transduction_Homo sapiens_hsa047423.04596313
5Lysosome_Homo sapiens_hsa041422.54160163
6Fatty acid elongation_Homo sapiens_hsa000622.41432447
7Butanoate metabolism_Homo sapiens_hsa006502.24372174
8Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001302.20399786
9ECM-receptor interaction_Homo sapiens_hsa045121.97641059
10Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.92380275
11Proteasome_Homo sapiens_hsa030501.90165619
12Vibrio cholerae infection_Homo sapiens_hsa051101.85774437
13Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.84008828
14Synaptic vesicle cycle_Homo sapiens_hsa047211.83284348
15Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.78036569
16Phagosome_Homo sapiens_hsa041451.74082885
17Basal transcription factors_Homo sapiens_hsa030221.71935121
18Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.70701942
19Focal adhesion_Homo sapiens_hsa045101.67743241
20Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.63534830
21Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054101.63441963
22Dilated cardiomyopathy_Homo sapiens_hsa054141.63418444
23Tryptophan metabolism_Homo sapiens_hsa003801.61369196
24Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.59935591
25Sphingolipid metabolism_Homo sapiens_hsa006001.59201577
26Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.53359878
27Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.52959682
28Pyrimidine metabolism_Homo sapiens_hsa002401.49952566
29beta-Alanine metabolism_Homo sapiens_hsa004101.47854733
30Collecting duct acid secretion_Homo sapiens_hsa049661.46589536
31Renal cell carcinoma_Homo sapiens_hsa052111.46033556
32Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.43419591
33Nicotine addiction_Homo sapiens_hsa050331.39385669
34Phototransduction_Homo sapiens_hsa047441.37497059
35Proteoglycans in cancer_Homo sapiens_hsa052051.36674628
36Huntingtons disease_Homo sapiens_hsa050161.35772906
37Oxidative phosphorylation_Homo sapiens_hsa001901.35552965
38Maturity onset diabetes of the young_Homo sapiens_hsa049501.34198715
39Endocytosis_Homo sapiens_hsa041441.31986997
40Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.31422643
41Bladder cancer_Homo sapiens_hsa052191.29999078
42Rheumatoid arthritis_Homo sapiens_hsa053231.27293890
43Folate biosynthesis_Homo sapiens_hsa007901.26371015
44Shigellosis_Homo sapiens_hsa051311.25395297
45Malaria_Homo sapiens_hsa051441.24999488
46RNA transport_Homo sapiens_hsa030131.23755884
47Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.23586333
48Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.23365060
49Lysine degradation_Homo sapiens_hsa003101.21651359
50Ribosome_Homo sapiens_hsa030101.20600259
51Amoebiasis_Homo sapiens_hsa051461.18390596
52Regulation of actin cytoskeleton_Homo sapiens_hsa048101.17298476
53Tight junction_Homo sapiens_hsa045301.16955224
54Vitamin B6 metabolism_Homo sapiens_hsa007501.16636292
55Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.15849104
56Steroid biosynthesis_Homo sapiens_hsa001001.15674900
57Gap junction_Homo sapiens_hsa045401.15192855
58Cardiac muscle contraction_Homo sapiens_hsa042601.15168581
59Glioma_Homo sapiens_hsa052141.14624668
60Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051201.13769133
61Selenocompound metabolism_Homo sapiens_hsa004501.12131013
62Sphingolipid signaling pathway_Homo sapiens_hsa040711.08555196
63Parkinsons disease_Homo sapiens_hsa050121.07831476
64Sulfur relay system_Homo sapiens_hsa041221.07256446
65Other glycan degradation_Homo sapiens_hsa005111.06392144
66Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.05437349
67One carbon pool by folate_Homo sapiens_hsa006701.05210414
68Linoleic acid metabolism_Homo sapiens_hsa005911.03625789
69GnRH signaling pathway_Homo sapiens_hsa049121.02850708
70Salmonella infection_Homo sapiens_hsa051321.01655665
71Axon guidance_Homo sapiens_hsa043600.96165483
72AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.96083477
73Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.95306450
74Nitrogen metabolism_Homo sapiens_hsa009100.95086137
75Estrogen signaling pathway_Homo sapiens_hsa049150.94131982
76Phospholipase D signaling pathway_Homo sapiens_hsa040720.93033411
77Sulfur metabolism_Homo sapiens_hsa009200.93002618
78Purine metabolism_Homo sapiens_hsa002300.92215695
79Glycosaminoglycan degradation_Homo sapiens_hsa005310.92004972
80VEGF signaling pathway_Homo sapiens_hsa043700.91674890
81Hippo signaling pathway_Homo sapiens_hsa043900.91504464
82Dorso-ventral axis formation_Homo sapiens_hsa043200.90751559
83Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.90677957
84Oxytocin signaling pathway_Homo sapiens_hsa049210.89245019
85Long-term depression_Homo sapiens_hsa047300.87375551
86Glycerolipid metabolism_Homo sapiens_hsa005610.87200707
87Neurotrophin signaling pathway_Homo sapiens_hsa047220.86979611
88Cocaine addiction_Homo sapiens_hsa050300.86460830
89alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.86071827
90Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.85596806
91Olfactory transduction_Homo sapiens_hsa047400.85139091
92Propanoate metabolism_Homo sapiens_hsa006400.83954854
93Leukocyte transendothelial migration_Homo sapiens_hsa046700.83658087
94Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.83180454
95Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.83115147
96Cholinergic synapse_Homo sapiens_hsa047250.82640013
97Insulin secretion_Homo sapiens_hsa049110.82098820
98ErbB signaling pathway_Homo sapiens_hsa040120.80240005
99Vascular smooth muscle contraction_Homo sapiens_hsa042700.79707927
100Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.79505182
101Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.79128957
102Peroxisome_Homo sapiens_hsa041460.78279157
103Gastric acid secretion_Homo sapiens_hsa049710.78152820
104Chronic myeloid leukemia_Homo sapiens_hsa052200.77877565
105Apoptosis_Homo sapiens_hsa042100.77062445
106Ras signaling pathway_Homo sapiens_hsa040140.75441026
107Tuberculosis_Homo sapiens_hsa051520.74690160
108GABAergic synapse_Homo sapiens_hsa047270.73246735
109PI3K-Akt signaling pathway_Homo sapiens_hsa041510.72418980
110Melanoma_Homo sapiens_hsa052180.72217936
111Salivary secretion_Homo sapiens_hsa049700.72050217
112Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.70584950
113Fanconi anemia pathway_Homo sapiens_hsa034600.69465697
114Rap1 signaling pathway_Homo sapiens_hsa040150.69331927
115Serotonergic synapse_Homo sapiens_hsa047260.68265977
116Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.68069500
117Prion diseases_Homo sapiens_hsa050200.67809109
118MAPK signaling pathway_Homo sapiens_hsa040100.67645353
119Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.67254033
120HIF-1 signaling pathway_Homo sapiens_hsa040660.66779067
121Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.66264409
122Regulation of autophagy_Homo sapiens_hsa041400.65657590
123Long-term potentiation_Homo sapiens_hsa047200.65593912
124Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.64042405
125Pancreatic cancer_Homo sapiens_hsa052120.63413888
126Melanogenesis_Homo sapiens_hsa049160.63387873
127Circadian entrainment_Homo sapiens_hsa047130.63216775
128Mineral absorption_Homo sapiens_hsa049780.62168866
129Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.61465582
130Homologous recombination_Homo sapiens_hsa034400.60947728
131Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.60401283
132Dopaminergic synapse_Homo sapiens_hsa047280.60162688
133p53 signaling pathway_Homo sapiens_hsa041150.60102356
134MicroRNAs in cancer_Homo sapiens_hsa052060.60071947
135Ether lipid metabolism_Homo sapiens_hsa005650.59741150
136Nucleotide excision repair_Homo sapiens_hsa034200.59580849
137mTOR signaling pathway_Homo sapiens_hsa041500.58955958
138SNARE interactions in vesicular transport_Homo sapiens_hsa041300.57861461
139Protein export_Homo sapiens_hsa030600.56275468
140Ovarian steroidogenesis_Homo sapiens_hsa049130.56105350
141Adherens junction_Homo sapiens_hsa045200.55997735
142TNF signaling pathway_Homo sapiens_hsa046680.54580224
143Platelet activation_Homo sapiens_hsa046110.54492071
144Metabolic pathways_Homo sapiens_hsa011000.53997020
145Glycerophospholipid metabolism_Homo sapiens_hsa005640.52672722
146Aldosterone synthesis and secretion_Homo sapiens_hsa049250.52485493
147Glutamatergic synapse_Homo sapiens_hsa047240.51845336
148Hedgehog signaling pathway_Homo sapiens_hsa043400.51766540
149Prostate cancer_Homo sapiens_hsa052150.51537550
150Small cell lung cancer_Homo sapiens_hsa052220.49725315
151Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.46903839
152Morphine addiction_Homo sapiens_hsa050320.45376713
153Steroid hormone biosynthesis_Homo sapiens_hsa001400.44639021
154Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.44357028
155Calcium signaling pathway_Homo sapiens_hsa040200.43088338
156Basal cell carcinoma_Homo sapiens_hsa052170.42165946
157Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.40347620
158Alzheimers disease_Homo sapiens_hsa050100.39385501
159Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.35992835
160Epstein-Barr virus infection_Homo sapiens_hsa051690.35348885
161Chemical carcinogenesis_Homo sapiens_hsa052040.29873043
162Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.28272800
163RNA degradation_Homo sapiens_hsa030180.27393697
164AMPK signaling pathway_Homo sapiens_hsa041520.26630687
165Glutathione metabolism_Homo sapiens_hsa004800.22886180
166Viral myocarditis_Homo sapiens_hsa054160.22705277
167Fatty acid metabolism_Homo sapiens_hsa012120.20635989

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