

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | purine nucleobase biosynthetic process (GO:0009113) | 5.49893102 |
| 2 | nucleobase biosynthetic process (GO:0046112) | 5.45628572 |
| 3 | melanin biosynthetic process (GO:0042438) | 5.01290399 |
| 4 | mitotic metaphase plate congression (GO:0007080) | 4.83431229 |
| 5 | ribosome assembly (GO:0042255) | 4.80390509 |
| 6 | ribosome biogenesis (GO:0042254) | 4.70514842 |
| 7 | maturation of SSU-rRNA (GO:0030490) | 4.57980378 |
| 8 | melanin metabolic process (GO:0006582) | 4.50655483 |
| 9 | formation of translation preinitiation complex (GO:0001731) | 4.46076959 |
| 10 | secondary metabolite biosynthetic process (GO:0044550) | 4.33778239 |
| 11 | DNA replication initiation (GO:0006270) | 4.26380228 |
| 12 | negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436) | 4.22816049 |
| 13 | nuclear pore organization (GO:0006999) | 4.16426949 |
| 14 | DNA replication checkpoint (GO:0000076) | 4.14246393 |
| 15 | regulation of spindle organization (GO:0090224) | 4.10464425 |
| 16 | ribonucleoprotein complex biogenesis (GO:0022613) | 4.09572943 |
| 17 | folic acid metabolic process (GO:0046655) | 4.08451704 |
| 18 | mitotic nuclear envelope disassembly (GO:0007077) | 4.08233733 |
| 19 | metaphase plate congression (GO:0051310) | 4.07231107 |
| 20 | DNA replication-dependent nucleosome organization (GO:0034723) | 4.04557072 |
| 21 | DNA replication-dependent nucleosome assembly (GO:0006335) | 4.04557072 |
| 22 | DNA strand elongation involved in DNA replication (GO:0006271) | 3.99626023 |
| 23 | cullin deneddylation (GO:0010388) | 3.99483407 |
| 24 | DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:00 | 3.96534333 |
| 25 | signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431) | 3.95672247 |
| 26 | intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400) | 3.95672247 |
| 27 | folic acid-containing compound biosynthetic process (GO:0009396) | 3.93539527 |
| 28 | signal transduction involved in mitotic cell cycle checkpoint (GO:0072413) | 3.93024202 |
| 29 | signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403) | 3.93024202 |
| 30 | signal transduction involved in mitotic DNA damage checkpoint (GO:1902402) | 3.93024202 |
| 31 | protein localization to kinetochore (GO:0034501) | 3.90813372 |
| 32 | regulation of cellular amino acid metabolic process (GO:0006521) | 3.90352255 |
| 33 | IMP biosynthetic process (GO:0006188) | 3.89367427 |
| 34 | negative regulation of ligase activity (GO:0051352) | 3.85143418 |
| 35 | negative regulation of ubiquitin-protein transferase activity (GO:0051444) | 3.85143418 |
| 36 | regulation of attachment of spindle microtubules to kinetochore (GO:0051988) | 3.84914624 |
| 37 | signal transduction involved in DNA integrity checkpoint (GO:0072401) | 3.81986961 |
| 38 | signal transduction involved in DNA damage checkpoint (GO:0072422) | 3.81986961 |
| 39 | ribosomal large subunit biogenesis (GO:0042273) | 3.81900617 |
| 40 | protein deneddylation (GO:0000338) | 3.81837722 |
| 41 | membrane disassembly (GO:0030397) | 3.79755151 |
| 42 | nuclear envelope disassembly (GO:0051081) | 3.79755151 |
| 43 | regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083) | 3.78733184 |
| 44 | DNA strand elongation (GO:0022616) | 3.78013635 |
| 45 | nuclear pore complex assembly (GO:0051292) | 3.74571996 |
| 46 | signal transduction involved in cell cycle checkpoint (GO:0072395) | 3.73727143 |
| 47 | DNA unwinding involved in DNA replication (GO:0006268) | 3.73150867 |
| 48 | regulation of posttranscriptional gene silencing (GO:0060147) | 3.67542166 |
| 49 | regulation of gene silencing by miRNA (GO:0060964) | 3.67542166 |
| 50 | regulation of gene silencing by RNA (GO:0060966) | 3.67542166 |
| 51 | rRNA processing (GO:0006364) | 3.65130557 |
| 52 | positive regulation of ubiquitin-protein transferase activity (GO:0051443) | 3.59131096 |
| 53 | regulation of mitotic spindle organization (GO:0060236) | 3.57072902 |
| 54 | rRNA metabolic process (GO:0016072) | 3.54948372 |
| 55 | telomere maintenance via semi-conservative replication (GO:0032201) | 3.54878058 |
| 56 | establishment of integrated proviral latency (GO:0075713) | 3.53753849 |
| 57 | positive regulation of chromosome segregation (GO:0051984) | 3.51951210 |
| 58 | protein localization to chromosome, centromeric region (GO:0071459) | 3.44319601 |
| 59 | transcription from mitochondrial promoter (GO:0006390) | 3.43399075 |
| 60 | positive regulation of ligase activity (GO:0051351) | 3.42656002 |
| 61 | spliceosomal snRNP assembly (GO:0000387) | 3.40709300 |
| 62 | DNA deamination (GO:0045006) | 3.37073293 |
| 63 | replication fork processing (GO:0031297) | 3.34856545 |
| 64 | establishment of chromosome localization (GO:0051303) | 3.34017830 |
| 65 | IMP metabolic process (GO:0046040) | 3.33332308 |
| 66 | chromatin remodeling at centromere (GO:0031055) | 3.32979514 |
| 67 | transcription elongation from RNA polymerase I promoter (GO:0006362) | 3.31931315 |
| 68 | regulation of ubiquitin-protein transferase activity (GO:0051438) | 3.31463382 |
| 69 | termination of RNA polymerase I transcription (GO:0006363) | 3.31017367 |
| 70 | ribosomal small subunit assembly (GO:0000028) | 3.25612967 |
| 71 | keratinocyte development (GO:0003334) | 3.24420191 |
| 72 | maturation of 5.8S rRNA (GO:0000460) | 3.24314130 |
| 73 | translational initiation (GO:0006413) | 3.23964097 |
| 74 | sister chromatid segregation (GO:0000819) | 3.23535595 |
| 75 | CENP-A containing nucleosome assembly (GO:0034080) | 3.23291213 |
| 76 | DNA replication-independent nucleosome assembly (GO:0006336) | 3.22552643 |
| 77 | DNA replication-independent nucleosome organization (GO:0034724) | 3.22552643 |
| 78 | rRNA modification (GO:0000154) | 3.22366087 |
| 79 | mitotic sister chromatid segregation (GO:0000070) | 3.21738605 |
| 80 | somatic diversification of immune receptors via somatic mutation (GO:0002566) | 3.21608432 |
| 81 | somatic hypermutation of immunoglobulin genes (GO:0016446) | 3.21608432 |
| 82 | telomere maintenance via recombination (GO:0000722) | 3.20877066 |
| 83 | transcription from RNA polymerase I promoter (GO:0006360) | 3.19794030 |
| 84 | regulation of ligase activity (GO:0051340) | 3.18744737 |
| 85 | attachment of spindle microtubules to kinetochore (GO:0008608) | 3.18706807 |
| 86 | regulation of chromosome segregation (GO:0051983) | 3.18463253 |
| 87 | G1/S transition of mitotic cell cycle (GO:0000082) | 3.17676081 |
| 88 | cell cycle G1/S phase transition (GO:0044843) | 3.17676081 |
| 89 | rRNA methylation (GO:0031167) | 3.17049494 |
| 90 | mitotic chromosome condensation (GO:0007076) | 3.16662323 |
| 91 | negative regulation of chromosome segregation (GO:0051985) | 3.15391782 |
| 92 | ribosomal small subunit biogenesis (GO:0042274) | 3.13338713 |
| 93 | anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:0 | 3.12871941 |
| 94 | telomere maintenance via telomere lengthening (GO:0010833) | 3.12515698 |
| 95 | double-strand break repair via nonhomologous end joining (GO:0006303) | 3.10252481 |
| 96 | non-recombinational repair (GO:0000726) | 3.10252481 |
| 97 | spindle checkpoint (GO:0031577) | 3.10179412 |
| 98 | mitotic recombination (GO:0006312) | 3.10004226 |
| 99 | nuclear envelope organization (GO:0006998) | 3.09910738 |
| 100 | mitotic spindle checkpoint (GO:0071174) | 3.07874491 |
| 101 | translational termination (GO:0006415) | 3.07088610 |
| 102 | negative regulation of mitotic sister chromatid separation (GO:2000816) | 3.06884133 |
| 103 | negative regulation of mitotic sister chromatid segregation (GO:0033048) | 3.06884133 |
| 104 | negative regulation of mitotic metaphase/anaphase transition (GO:0045841) | 3.06884133 |
| 105 | negative regulation of sister chromatid segregation (GO:0033046) | 3.06884133 |
| 106 | DNA damage response, signal transduction by p53 class mediator (GO:0030330) | 3.06030868 |
| 107 | transcription initiation from RNA polymerase I promoter (GO:0006361) | 3.04717690 |
| 108 | regulation of helicase activity (GO:0051095) | 3.04603792 |
| 109 | proteasome assembly (GO:0043248) | 3.03999920 |
| 110 | viral transcription (GO:0019083) | 3.03971424 |
| 111 | regulation of nuclear cell cycle DNA replication (GO:0033262) | 3.03511552 |
| 112 | protein K6-linked ubiquitination (GO:0085020) | 3.03475368 |
| 113 | negative regulation of histone methylation (GO:0031061) | 3.02170584 |
| 114 | DNA catabolic process, exonucleolytic (GO:0000738) | 3.01762412 |
| 115 | kinetochore organization (GO:0051383) | 3.01422450 |
| 116 | mitotic spindle assembly checkpoint (GO:0007094) | 3.01040974 |
| 117 | transcription elongation from RNA polymerase III promoter (GO:0006385) | 2.99886493 |
| 118 | termination of RNA polymerase III transcription (GO:0006386) | 2.99886493 |
| 119 | regulation of translation in response to stress (GO:0043555) | 2.99412607 |
| 120 | pseudouridine synthesis (GO:0001522) | 2.99345695 |
| 121 | negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100) | 2.99209311 |
| 122 | regulation of DNA endoreduplication (GO:0032875) | 2.98820304 |
| 123 | transcription-coupled nucleotide-excision repair (GO:0006283) | 2.98640216 |
| 124 | somatic diversification of immunoglobulins involved in immune response (GO:0002208) | 2.98602268 |
| 125 | isotype switching (GO:0045190) | 2.98602268 |
| 126 | somatic recombination of immunoglobulin genes involved in immune response (GO:0002204) | 2.98602268 |
| 127 | histone exchange (GO:0043486) | 2.98515216 |
| 128 | regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439) | 2.98069742 |
| 129 | positive regulation of cell cycle arrest (GO:0071158) | 2.97968208 |
| 130 | kinetochore assembly (GO:0051382) | 2.96962930 |
| 131 | pore complex assembly (GO:0046931) | 2.96949554 |
| 132 | spindle assembly checkpoint (GO:0071173) | 2.96569136 |
| 133 | tRNA aminoacylation for protein translation (GO:0006418) | 2.96117710 |
| 134 | synapsis (GO:0007129) | 2.95886534 |
| 135 | amino acid activation (GO:0043038) | 2.95866171 |
| 136 | tRNA aminoacylation (GO:0043039) | 2.95866171 |
| 137 | lactate metabolic process (GO:0006089) | 2.94684342 |
| 138 | regulation of mitotic metaphase/anaphase transition (GO:0030071) | 2.94342662 |
| 139 | establishment of viral latency (GO:0019043) | 2.93849860 |
| 140 | positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437) | 2.92880165 |
| 141 | pre-miRNA processing (GO:0031054) | 2.92726835 |
| 142 | regulation of centrosome cycle (GO:0046605) | 2.92645529 |
| 143 | regulation of translational termination (GO:0006449) | 2.92014042 |
| 144 | negative regulation of protein ubiquitination (GO:0031397) | 2.91089884 |
| 145 | DNA duplex unwinding (GO:0032508) | 2.90019640 |
| 146 | mitochondrial RNA metabolic process (GO:0000959) | 2.89854496 |
| 147 | DNA geometric change (GO:0032392) | 2.89601508 |
| 148 | blastocyst development (GO:0001824) | 2.89548180 |
| 149 | DNA double-strand break processing (GO:0000729) | 2.89368769 |
| 150 | regulation of cellular amine metabolic process (GO:0033238) | 2.86967622 |
| 151 | negative regulation of protein modification by small protein conjugation or removal (GO:1903321) | 2.84402994 |
| 152 | pigment biosynthetic process (GO:0046148) | 2.81292193 |
| 153 | dolichol-linked oligosaccharide biosynthetic process (GO:0006488) | 2.80261429 |
| 154 | establishment of protein localization to mitochondrial membrane (GO:0090151) | 2.77006401 |
| 155 | maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005) | 2.75157877 |
| 156 | RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503) | 2.73718187 |
| 157 | response to X-ray (GO:0010165) | 2.72244599 |
| 158 | protein maturation by protein folding (GO:0022417) | 2.71920634 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | E2F7_22180533_ChIP-Seq_HELA_Human | 7.90479218 |
| 2 | * MYC_18555785_ChIP-Seq_MESCs_Mouse | 4.39922206 |
| 3 | FOXM1_23109430_ChIP-Seq_U2OS_Human | 3.76655856 |
| 4 | MYC_19079543_ChIP-ChIP_MESCs_Mouse | 3.43068686 |
| 5 | E2F4_17652178_ChIP-ChIP_JURKAT_Human | 3.24504525 |
| 6 | EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse | 3.19997578 |
| 7 | FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human | 2.87742732 |
| 8 | * MYC_19030024_ChIP-ChIP_MESCs_Mouse | 2.86653257 |
| 9 | * MYC_18358816_ChIP-ChIP_MESCs_Mouse | 2.79239554 |
| 10 | ETS1_20019798_ChIP-Seq_JURKAT_Human | 2.77185139 |
| 11 | KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human | 2.72039267 |
| 12 | E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse | 2.69751712 |
| 13 | EST1_17652178_ChIP-ChIP_JURKAT_Human | 2.65359584 |
| 14 | JARID1A_20064375_ChIP-Seq_MESCs_Mouse | 2.63716330 |
| 15 | CREB1_15753290_ChIP-ChIP_HEK293T_Human | 2.57115110 |
| 16 | TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse | 2.56868638 |
| 17 | GABP_17652178_ChIP-ChIP_JURKAT_Human | 2.45616584 |
| 18 | MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse | 2.44557428 |
| 19 | NELFA_20434984_ChIP-Seq_ESCs_Mouse | 2.35967380 |
| 20 | NANOG_18555785_ChIP-Seq_MESCs_Mouse | 2.27111503 |
| 21 | XRN2_22483619_ChIP-Seq_HELA_Human | 2.25542864 |
| 22 | AR_21909140_ChIP-Seq_LNCAP_Human | 2.25161904 |
| 23 | POU5F1_18700969_ChIP-ChIP_MESCs_Mouse | 2.23505499 |
| 24 | CHD1_19587682_ChIP-ChIP_MESCs_Mouse | 2.18580653 |
| 25 | VDR_23849224_ChIP-Seq_CD4+_Human | 2.04824967 |
| 26 | KDM5B_21448134_ChIP-Seq_MESCs_Mouse | 2.04012000 |
| 27 | SMAD4_19686287_ChIP-ChIP_HaCaT_Human | 2.03775269 |
| 28 | SMAD1_18555785_ChIP-Seq_MESCs_Mouse | 2.02169940 |
| 29 | * POU5F1_18555785_ChIP-Seq_MESCs_Mouse | 1.99380159 |
| 30 | MYBL2_22936984_ChIP-ChIP_MESCs_Mouse | 1.95406071 |
| 31 | * E2F1_18555785_ChIP-Seq_MESCs_Mouse | 1.95223044 |
| 32 | MYCN_18555785_ChIP-Seq_MESCs_Mouse | 1.95128665 |
| 33 | HCFC1_20581084_ChIP-Seq_MESCs_Mouse | 1.92629454 |
| 34 | KLF2_18264089_ChIP-ChIP_MESCs_Mouse | 1.82213625 |
| 35 | KLF5_18264089_ChIP-ChIP_MESCs_Mouse | 1.82213625 |
| 36 | KLF4_18264089_ChIP-ChIP_MESCs_Mouse | 1.82213625 |
| 37 | E2F1_21310950_ChIP-Seq_MCF-7_Human | 1.77125342 |
| 38 | STAT3_1855785_ChIP-Seq_MESCs_Mouse | 1.75285940 |
| 39 | GABP_19822575_ChIP-Seq_HepG2_Human | 1.73369843 |
| 40 | FOXP3_21729870_ChIP-Seq_TREG_Human | 1.72612402 |
| 41 | DCP1A_22483619_ChIP-Seq_HELA_Human | 1.71011561 |
| 42 | TTF2_22483619_ChIP-Seq_HELA_Human | 1.66834663 |
| 43 | NACC1_18358816_ChIP-ChIP_MESCs_Mouse | 1.66611215 |
| 44 | SOX9_22984422_ChIP-ChIP_TESTIS_Rat | 1.61052909 |
| 45 | NANOG_18700969_ChIP-ChIP_MESCs_Mouse | 1.60383134 |
| 46 | NOTCH1_17114293_ChIP-ChIP_T-ALL_Human | 1.59553410 |
| 47 | POU5F1_18358816_ChIP-ChIP_MESCs_Mouse | 1.57333623 |
| 48 | EGR1_19374776_ChIP-ChIP_THP-1_Human | 1.57316585 |
| 49 | YY1_21170310_ChIP-Seq_MESCs_Mouse | 1.56746471 |
| 50 | THAP11_20581084_ChIP-Seq_MESCs_Mouse | 1.55253381 |
| 51 | KDM5A_27292631_Chip-Seq_BREAST_Human | 1.49780859 |
| 52 | SALL1_21062744_ChIP-ChIP_HESCs_Human | 1.49156858 |
| 53 | YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse | 1.48951685 |
| 54 | MYC_22102868_ChIP-Seq_BL_Human | 1.47617316 |
| 55 | HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human | 1.46867181 |
| 56 | TCF3_18692474_ChIP-Seq_MEFs_Mouse | 1.44964952 |
| 57 | KLF4_18555785_ChIP-Seq_MESCs_Mouse | 1.44960835 |
| 58 | PRDM5_23873026_ChIP-Seq_MEFs_Mouse | 1.41180283 |
| 59 | ZFX_18555785_ChIP-Seq_MESCs_Mouse | 1.40899606 |
| 60 | CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human | 1.40300346 |
| 61 | HNF4A_19761587_ChIP-ChIP_CACO-2_Human | 1.39698421 |
| 62 | PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse | 1.39546807 |
| 63 | * KLF4_18358816_ChIP-ChIP_MESCs_Mouse | 1.37240434 |
| 64 | CIITA_25753668_ChIP-Seq_RAJI_Human | 1.36882343 |
| 65 | ZFP42_18358816_ChIP-ChIP_MESCs_Mouse | 1.35988205 |
| 66 | SOX2_18555785_ChIP-Seq_MESCs_Mouse | 1.34371913 |
| 67 | ZNF263_19887448_ChIP-Seq_K562_Human | 1.29786149 |
| 68 | MYCN_21190229_ChIP-Seq_SHEP-21N_Human | 1.25512438 |
| 69 | ELK1_22589737_ChIP-Seq_MCF10A_Human | 1.25295779 |
| 70 | SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse | 1.21498351 |
| 71 | ELF5_23300383_ChIP-Seq_T47D_Human | 1.19786984 |
| 72 | FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse | 1.18488079 |
| 73 | * NANOG_18358816_ChIP-ChIP_MESCs_Mouse | 1.18252467 |
| 74 | * TCF3_18692474_ChIP-Seq_MESCs_Mouse | 1.18206801 |
| 75 | SOX17_20123909_ChIP-Seq_XEN_Mouse | 1.17517815 |
| 76 | ELK1_19687146_ChIP-ChIP_HELA_Human | 1.15048568 |
| 77 | ZIC3_20872845_ChIP-ChIP_MESCs_Mouse | 1.15001958 |
| 78 | * NR0B1_18358816_ChIP-ChIP_MESCs_Mouse | 1.14017126 |
| 79 | TP63_19390658_ChIP-ChIP_HaCaT_Human | 1.13481024 |
| 80 | KLF4_19030024_ChIP-ChIP_MESCs_Mouse | 1.12965405 |
| 81 | ERG_20887958_ChIP-Seq_HPC-7_Mouse | 1.12754790 |
| 82 | DACH1_20351289_ChIP-Seq_MDA-MB-231_Human | 1.11652245 |
| 83 | TAL1_20887958_ChIP-Seq_HPC-7_Mouse | 1.11631606 |
| 84 | EWS_26573619_Chip-Seq_HEK293_Human | 1.11235202 |
| 85 | * SOX2_18692474_ChIP-Seq_MEFs_Mouse | 1.10455426 |
| 86 | PDX1_19855005_ChIP-ChIP_MIN6_Mouse | 1.09911857 |
| 87 | OCT4_18692474_ChIP-Seq_MEFs_Mouse | 1.09070931 |
| 88 | CEBPB_23403033_ChIP-Seq_LIVER_Mouse | 1.08133263 |
| 89 | ASH2L_23239880_ChIP-Seq_MESCs_Mouse | 1.07285448 |
| 90 | CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat | 1.06827971 |
| 91 | NANOG_21062744_ChIP-ChIP_HESCs_Human | 1.06685014 |
| 92 | NOTCH1_21737748_ChIP-Seq_TLL_Human | 1.04582448 |
| 93 | FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human | 1.04142598 |
| 94 | ZFP281_18358816_ChIP-ChIP_MESCs_Mouse | 1.03930234 |
| 95 | CCND1_20090754_ChIP-ChIP_RETINA_Mouse | 1.03911090 |
| 96 | CREM_20920259_ChIP-Seq_GC1-SPG_Mouse | 1.03594969 |
| 97 | ELF1_17652178_ChIP-ChIP_JURKAT_Human | 1.02580271 |
| 98 | HOXB4_20404135_ChIP-ChIP_EML_Mouse | 1.02019004 |
| 99 | SOX2_18358816_ChIP-ChIP_MESCs_Mouse | 1.00364870 |
| 100 | ASXL1_24218140_ChIP-Seq_BMDM_Mouse | 0.99021669 |
| 101 | * POU5F1_18692474_ChIP-Seq_MESCs_Mouse | 0.97754964 |
| 102 | TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat | 0.97714157 |
| 103 | * NANOG_18692474_ChIP-Seq_MEFs_Mouse | 0.97408738 |
| 104 | * SOX2_18692474_ChIP-Seq_MESCs_Mouse | 0.96981282 |
| 105 | PADI4_21655091_ChIP-ChIP_MCF-7_Human | 0.96740955 |
| 106 | SIN3A_21632747_ChIP-Seq_MESCs_Mouse | 0.96477280 |
| 107 | TFEB_21752829_ChIP-Seq_HELA_Human | 0.95751379 |
| 108 | SRF_21415370_ChIP-Seq_HL-1_Mouse | 0.94538002 |
| 109 | SFPI1_20887958_ChIP-Seq_HPC-7_Mouse | 0.93784041 |
| 110 | E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human | 0.93360661 |
| 111 | VDR_22108803_ChIP-Seq_LS180_Human | 0.93138562 |
| 112 | SALL4_18804426_ChIP-ChIP_MESCs_Mouse | 0.92910925 |
| 113 | CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human | 0.92151351 |
| 114 | CNOT3_19339689_ChIP-ChIP_MESCs_Mouse | 0.91880014 |
| 115 | EOMES_20176728_ChIP-ChIP_TSCs_Mouse | 0.88316857 |
| 116 | MYC_18940864_ChIP-ChIP_HL60_Human | 0.87743397 |
| 117 | HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse | 0.87717477 |
| 118 | KAP1_27257070_Chip-Seq_ESCs_Mouse | 0.86749802 |
| 119 | * GATA6_25053715_ChIP-Seq_YYC3_Human | 0.83608242 |
| 120 | BCL3_23251550_ChIP-Seq_MUSCLE_Mouse | 0.82835250 |
| 121 | CEBPA_23403033_ChIP-Seq_LIVER_Mouse | 0.81617846 |
| 122 | CHD1_26751641_Chip-Seq_LNCaP_Human | 0.80134145 |
| 123 | * SMAD2_18955504_ChIP-ChIP_HaCaT_Human | 0.79921702 |
| 124 | * SMAD3_18955504_ChIP-ChIP_HaCaT_Human | 0.79921702 |
| 125 | FUS_26573619_Chip-Seq_HEK293_Human | 0.77862082 |
| 126 | TBX5_21415370_ChIP-Seq_HL-1_Mouse | 0.76687714 |
| 127 | SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse | 0.73756197 |
| 128 | NANOG_16153702_ChIP-ChIP_HESCs_Human | 0.70605718 |
| 129 | FLI1_20887958_ChIP-Seq_HPC-7_Mouse | 0.70344683 |
| 130 | ATF3_23680149_ChIP-Seq_GBM1-GSC_Human | 0.69947826 |
| 131 | GFI1B_20887958_ChIP-Seq_HPC-7_Mouse | 0.64873952 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | MP0003693_abnormal_embryo_hatching | 6.08396614 |
| 2 | MP0000372_irregular_coat_pigmentation | 5.91853715 |
| 3 | MP0003111_abnormal_nucleus_morphology | 4.85749648 |
| 4 | MP0004957_abnormal_blastocyst_morpholog | 4.75922296 |
| 5 | MP0010094_abnormal_chromosome_stability | 4.52107120 |
| 6 | MP0005408_hypopigmentation | 3.98718670 |
| 7 | MP0003077_abnormal_cell_cycle | 3.94357124 |
| 8 | MP0008057_abnormal_DNA_replication | 3.58103050 |
| 9 | MP0008058_abnormal_DNA_repair | 3.34662544 |
| 10 | MP0005075_abnormal_melanosome_morpholog | 3.30003777 |
| 11 | MP0005171_absent_coat_pigmentation | 3.23865234 |
| 12 | MP0003718_maternal_effect | 3.01234926 |
| 13 | MP0008877_abnormal_DNA_methylation | 2.86997519 |
| 14 | MP0002877_abnormal_melanocyte_morpholog | 2.84159879 |
| 15 | MP0000015_abnormal_ear_pigmentation | 2.78379387 |
| 16 | MP0003123_paternal_imprinting | 2.77540175 |
| 17 | MP0001730_embryonic_growth_arrest | 2.76435578 |
| 18 | MP0002102_abnormal_ear_morphology | 2.51827876 |
| 19 | MP0008932_abnormal_embryonic_tissue | 2.51776897 |
| 20 | MP0003136_yellow_coat_color | 2.45869773 |
| 21 | MP0003786_premature_aging | 2.41211198 |
| 22 | MP0000350_abnormal_cell_proliferation | 2.37870391 |
| 23 | MP0005377_hearing/vestibular/ear_phenot | 2.35829110 |
| 24 | MP0003878_abnormal_ear_physiology | 2.35829110 |
| 25 | MP0008007_abnormal_cellular_replicative | 2.35459838 |
| 26 | MP0009697_abnormal_copulation | 2.26673257 |
| 27 | MP0006054_spinal_hemorrhage | 2.21954846 |
| 28 | MP0010352_gastrointestinal_tract_polyps | 2.16529710 |
| 29 | MP0003950_abnormal_plasma_membrane | 2.13612060 |
| 30 | MP0004381_abnormal_hair_follicle | 2.10733838 |
| 31 | MP0001672_abnormal_embryogenesis/_devel | 2.07391411 |
| 32 | MP0005380_embryogenesis_phenotype | 2.07391411 |
| 33 | MP0002095_abnormal_skin_pigmentation | 2.04339460 |
| 34 | MP0010307_abnormal_tumor_latency | 2.01328235 |
| 35 | MP0000371_diluted_coat_color | 1.94366165 |
| 36 | MP0005174_abnormal_tail_pigmentation | 1.92983455 |
| 37 | MP0005257_abnormal_intraocular_pressure | 1.86608869 |
| 38 | MP0001697_abnormal_embryo_size | 1.85073197 |
| 39 | MP0003984_embryonic_growth_retardation | 1.82058735 |
| 40 | MP0002088_abnormal_embryonic_growth/wei | 1.78000349 |
| 41 | MP0002080_prenatal_lethality | 1.73727562 |
| 42 | MP0002396_abnormal_hematopoietic_system | 1.70667435 |
| 43 | MP0002085_abnormal_embryonic_tissue | 1.70363675 |
| 44 | MP0002938_white_spotting | 1.70174889 |
| 45 | MP0002084_abnormal_developmental_patter | 1.64217445 |
| 46 | MP0002086_abnormal_extraembryonic_tissu | 1.63231842 |
| 47 | MP0002210_abnormal_sex_determination | 1.61367584 |
| 48 | MP0003806_abnormal_nucleotide_metabolis | 1.59709596 |
| 49 | MP0002653_abnormal_ependyma_morphology | 1.53887826 |
| 50 | MP0003315_abnormal_perineum_morphology | 1.49467484 |
| 51 | MP0001145_abnormal_male_reproductive | 1.48365025 |
| 52 | MP0000490_abnormal_crypts_of | 1.46147659 |
| 53 | MP0006036_abnormal_mitochondrial_physio | 1.45024544 |
| 54 | MP0010678_abnormal_skin_adnexa | 1.40720783 |
| 55 | MP0000537_abnormal_urethra_morphology | 1.39722934 |
| 56 | MP0003941_abnormal_skin_development | 1.37645295 |
| 57 | MP0001324_abnormal_eye_pigmentation | 1.35495151 |
| 58 | MP0000313_abnormal_cell_death | 1.34693428 |
| 59 | MP0001929_abnormal_gametogenesis | 1.34235285 |
| 60 | MP0002006_tumorigenesis | 1.32810811 |
| 61 | MP0009840_abnormal_foam_cell | 1.32451824 |
| 62 | MP0003567_abnormal_fetal_cardiomyocyte | 1.32420648 |
| 63 | MP0003186_abnormal_redox_activity | 1.32324402 |
| 64 | MP0004197_abnormal_fetal_growth/weight/ | 1.32214921 |
| 65 | MP0004264_abnormal_extraembryonic_tissu | 1.30593198 |
| 66 | MP0009333_abnormal_splenocyte_physiolog | 1.29618555 |
| 67 | MP0001293_anophthalmia | 1.29031226 |
| 68 | MP0003119_abnormal_digestive_system | 1.26691630 |
| 69 | MP0000653_abnormal_sex_gland | 1.24854992 |
| 70 | MP0002166_altered_tumor_susceptibility | 1.24647106 |
| 71 | MP0002019_abnormal_tumor_incidence | 1.20945762 |
| 72 | MP0002075_abnormal_coat/hair_pigmentati | 1.18900354 |
| 73 | MP0003943_abnormal_hepatobiliary_system | 1.15414753 |
| 74 | MP0002090_abnormal_vision | 1.13612775 |
| 75 | MP0002160_abnormal_reproductive_system | 1.12038532 |
| 76 | MP0001186_pigmentation_phenotype | 1.09671377 |
| 77 | MP0003890_abnormal_embryonic-extraembry | 1.07134966 |
| 78 | MP0000647_abnormal_sebaceous_gland | 1.03307797 |
| 79 | MP0008260_abnormal_autophagy | 1.02852205 |
| 80 | MP0003646_muscle_fatigue | 1.02502292 |
| 81 | MP0008995_early_reproductive_senescence | 1.01831398 |
| 82 | MP0003121_genomic_imprinting | 1.00594934 |
| 83 | MP0003195_calcinosis | 1.00527620 |
| 84 | MP0005197_abnormal_uvea_morphology | 0.99183423 |
| 85 | MP0005395_other_phenotype | 0.96239905 |
| 86 | MP0006292_abnormal_olfactory_placode | 0.95601814 |
| 87 | MP0004133_heterotaxia | 0.94490684 |
| 88 | MP0009672_abnormal_birth_weight | 0.94105396 |
| 89 | MP0005076_abnormal_cell_differentiation | 0.90834216 |
| 90 | MP0000358_abnormal_cell_content/ | 0.90323537 |
| 91 | MP0005389_reproductive_system_phenotype | 0.90114334 |
| 92 | MP0003698_abnormal_male_reproductive | 0.84896467 |
| 93 | MP0003221_abnormal_cardiomyocyte_apopto | 0.84797381 |
| 94 | MP0004808_abnormal_hematopoietic_stem | 0.84504443 |
| 95 | MP0001119_abnormal_female_reproductive | 0.83009950 |
| 96 | MP0000703_abnormal_thymus_morphology | 0.81480005 |
| 97 | MP0003763_abnormal_thymus_physiology | 0.81317416 |
| 98 | MP0000377_abnormal_hair_follicle | 0.81116474 |
| 99 | MP0010234_abnormal_vibrissa_follicle | 0.80673855 |
| 100 | MP0005397_hematopoietic_system_phenotyp | 0.78113052 |
| 101 | MP0001545_abnormal_hematopoietic_system | 0.78113052 |
| 102 | MP0001849_ear_inflammation | 0.77784128 |
| 103 | MP0004147_increased_porphyrin_level | 0.77239337 |
| 104 | MP0005384_cellular_phenotype | 0.77224143 |
| 105 | MP0003699_abnormal_female_reproductive | 0.75704948 |
| 106 | MP0000427_abnormal_hair_cycle | 0.75516495 |
| 107 | MP0005621_abnormal_cell_physiology | 0.75209532 |
| 108 | MP0002282_abnormal_trachea_morphology | 0.74679894 |
| 109 | MP0002722_abnormal_immune_system | 0.74488921 |
| 110 | MP0000477_abnormal_intestine_morphology | 0.73532632 |
| 111 | MP0002161_abnormal_fertility/fecundity | 0.72868040 |
| 112 | MP0003936_abnormal_reproductive_system | 0.72550941 |
| 113 | MP0009278_abnormal_bone_marrow | 0.72456131 |
| 114 | MP0002060_abnormal_skin_morphology | 0.70849127 |
| 115 | MP0001661_extended_life_span | 0.69866274 |
| 116 | MP0002092_abnormal_eye_morphology | 0.69452778 |
| 117 | MP0009703_decreased_birth_body | 0.68841138 |
| 118 | MP0000749_muscle_degeneration | 0.68620116 |
| 119 | MP0001919_abnormal_reproductive_system | 0.68618597 |
| 120 | MP0000383_abnormal_hair_follicle | 0.68361861 |
| 121 | MP0005165_increased_susceptibility_to | 0.68195644 |
| 122 | MP0000689_abnormal_spleen_morphology | 0.67327357 |
| 123 | MP0004233_abnormal_muscle_weight | 0.67264847 |
| 124 | MP0005501_abnormal_skin_physiology | 0.66537722 |
| 125 | MP0002177_abnormal_outer_ear | 0.65105347 |
| 126 | MP0003937_abnormal_limbs/digits/tail_de | 0.64226760 |
| 127 | MP0002111_abnormal_tail_morphology | 0.63325751 |
| 128 | MP0005266_abnormal_metabolism | 0.62740162 |
| 129 | MP0004272_abnormal_basement_membrane | 0.62400289 |
| 130 | MP0000613_abnormal_salivary_gland | 0.61789264 |
| 131 | MP0005451_abnormal_body_composition | 0.61254327 |
| 132 | MP0002398_abnormal_bone_marrow | 0.60281291 |
| 133 | MP0001216_abnormal_epidermal_layer | 0.60167696 |
| 134 | MP0003938_abnormal_ear_development | 0.58447385 |
| 135 | MP0004019_abnormal_vitamin_homeostasis | 0.58256529 |
| 136 | MP0006035_abnormal_mitochondrial_morpho | 0.58149937 |
| 137 | MP0003866_abnormal_defecation | 0.56687431 |
| 138 | MP0001727_abnormal_embryo_implantation | 0.55882986 |
| 139 | MP0005367_renal/urinary_system_phenotyp | 0.55458072 |
| 140 | MP0000516_abnormal_urinary_system | 0.55458072 |
| 141 | MP0002127_abnormal_cardiovascular_syste | 0.55434979 |
| 142 | MP0002796_impaired_skin_barrier | 0.53881879 |
| 143 | MP0000627_abnormal_mammary_gland | 0.53668318 |
| 144 | MP0010030_abnormal_orbit_morphology | 0.51649830 |
| 145 | MP0001853_heart_inflammation | 0.49391759 |
| 146 | MP0001485_abnormal_pinna_reflex | 0.49378838 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | Birth length less than 3rd percentile (HP:0003561) | 5.25926377 |
| 2 | Breast hypoplasia (HP:0003187) | 5.17420147 |
| 3 | Ependymoma (HP:0002888) | 4.11859950 |
| 4 | Carpal bone hypoplasia (HP:0001498) | 3.99771841 |
| 5 | Patchy hypopigmentation of hair (HP:0011365) | 3.97487485 |
| 6 | Impulsivity (HP:0100710) | 3.96886408 |
| 7 | Abnormality of the labia minora (HP:0012880) | 3.93693411 |
| 8 | Aplasia/Hypoplasia of the macula (HP:0008059) | 3.79744655 |
| 9 | Hypoplasia of the fovea (HP:0007750) | 3.71683498 |
| 10 | Aplasia/Hypoplasia of the fovea (HP:0008060) | 3.71683498 |
| 11 | White forelock (HP:0002211) | 3.67082380 |
| 12 | Absent radius (HP:0003974) | 3.64821457 |
| 13 | Reticulocytopenia (HP:0001896) | 3.64704678 |
| 14 | Rough bone trabeculation (HP:0100670) | 3.63145785 |
| 15 | Abnormality of glycolysis (HP:0004366) | 3.61235974 |
| 16 | Cerebral hypomyelination (HP:0006808) | 3.58017577 |
| 17 | Aplasia/Hypoplasia affecting the retina (HP:0008061) | 3.50847984 |
| 18 | Supernumerary spleens (HP:0009799) | 3.50656174 |
| 19 | Patellar aplasia (HP:0006443) | 3.44311490 |
| 20 | Oral leukoplakia (HP:0002745) | 3.43690547 |
| 21 | Aplasia involving forearm bones (HP:0009822) | 3.39713868 |
| 22 | Absent forearm bone (HP:0003953) | 3.39713868 |
| 23 | Aplasia/Hypoplasia of the patella (HP:0006498) | 3.28316206 |
| 24 | Colon cancer (HP:0003003) | 3.25472187 |
| 25 | Abnormality of the anterior horn cell (HP:0006802) | 3.25301599 |
| 26 | Degeneration of anterior horn cells (HP:0002398) | 3.25301599 |
| 27 | Abnormal auditory evoked potentials (HP:0006958) | 3.25072003 |
| 28 | Chromsome breakage (HP:0040012) | 3.24306393 |
| 29 | Selective tooth agenesis (HP:0001592) | 3.19210718 |
| 30 | Cutaneous melanoma (HP:0012056) | 3.17166783 |
| 31 | Chromosomal breakage induced by crosslinking agents (HP:0003221) | 3.16499901 |
| 32 | Ocular albinism (HP:0001107) | 3.13092830 |
| 33 | Abnormality of the fovea (HP:0000493) | 3.11867054 |
| 34 | Type I transferrin isoform profile (HP:0003642) | 2.99015906 |
| 35 | Abnormality of methionine metabolism (HP:0010901) | 2.96752702 |
| 36 | Medulloblastoma (HP:0002885) | 2.96649159 |
| 37 | Abnormality of cells of the erythroid lineage (HP:0012130) | 2.95426634 |
| 38 | Aplasia/Hypoplasia involving the carpal bones (HP:0006502) | 2.94722813 |
| 39 | Posterior subcapsular cataract (HP:0007787) | 2.89755680 |
| 40 | Increased serum pyruvate (HP:0003542) | 2.88583927 |
| 41 | Premature ovarian failure (HP:0008209) | 2.82667244 |
| 42 | Rhabdomyosarcoma (HP:0002859) | 2.81849018 |
| 43 | Aplasia/hypoplasia of the humerus (HP:0006507) | 2.75581714 |
| 44 | Reduced antithrombin III activity (HP:0001976) | 2.74967510 |
| 45 | Iris hypopigmentation (HP:0007730) | 2.74117660 |
| 46 | Abnormal trabecular bone morphology (HP:0100671) | 2.72595041 |
| 47 | Macrocytic anemia (HP:0001972) | 2.69685099 |
| 48 | Absent thumb (HP:0009777) | 2.69396249 |
| 49 | 11 pairs of ribs (HP:0000878) | 2.69337830 |
| 50 | Abnormality of the preputium (HP:0100587) | 2.69125308 |
| 51 | Acute encephalopathy (HP:0006846) | 2.68976825 |
| 52 | Sparse eyelashes (HP:0000653) | 2.68220681 |
| 53 | Hyperglycinemia (HP:0002154) | 2.67292479 |
| 54 | Meckel diverticulum (HP:0002245) | 2.66172519 |
| 55 | Abnormality of chromosome stability (HP:0003220) | 2.65841997 |
| 56 | Sensory axonal neuropathy (HP:0003390) | 2.64365929 |
| 57 | Astrocytoma (HP:0009592) | 2.59116036 |
| 58 | Abnormality of the astrocytes (HP:0100707) | 2.59116036 |
| 59 | Abnormal lung lobation (HP:0002101) | 2.58799944 |
| 60 | Abnormal number of erythroid precursors (HP:0012131) | 2.58538526 |
| 61 | Increased CSF lactate (HP:0002490) | 2.55735904 |
| 62 | Abnormal protein glycosylation (HP:0012346) | 2.55182944 |
| 63 | Abnormal glycosylation (HP:0012345) | 2.55182944 |
| 64 | Abnormal isoelectric focusing of serum transferrin (HP:0003160) | 2.55182944 |
| 65 | Abnormal protein N-linked glycosylation (HP:0012347) | 2.55182944 |
| 66 | Agnosia (HP:0010524) | 2.54816137 |
| 67 | Acute necrotizing encephalopathy (HP:0006965) | 2.54636008 |
| 68 | Horseshoe kidney (HP:0000085) | 2.54330685 |
| 69 | Abnormality of the ileum (HP:0001549) | 2.51523347 |
| 70 | Glioma (HP:0009733) | 2.51427348 |
| 71 | Ureteral duplication (HP:0000073) | 2.50457791 |
| 72 | Neoplasm of the pancreas (HP:0002894) | 2.50404141 |
| 73 | Stenosis of the external auditory canal (HP:0000402) | 2.48578965 |
| 74 | Adrenal hypoplasia (HP:0000835) | 2.48306622 |
| 75 | Abnormal gallbladder physiology (HP:0012438) | 2.47367976 |
| 76 | Cholecystitis (HP:0001082) | 2.47367976 |
| 77 | Hyperglycinuria (HP:0003108) | 2.47165323 |
| 78 | Abnormality of aspartate family amino acid metabolism (HP:0010899) | 2.45624154 |
| 79 | Freckling (HP:0001480) | 2.39905949 |
| 80 | Progressive macrocephaly (HP:0004481) | 2.38721144 |
| 81 | Abnormal spermatogenesis (HP:0008669) | 2.38180878 |
| 82 | Microretrognathia (HP:0000308) | 2.37892612 |
| 83 | Short humerus (HP:0005792) | 2.36140096 |
| 84 | Megaloblastic anemia (HP:0001889) | 2.35680517 |
| 85 | Albinism (HP:0001022) | 2.35469627 |
| 86 | Spinal muscular atrophy (HP:0007269) | 2.33967657 |
| 87 | Aplasia/Hypoplasia of the uvula (HP:0010293) | 2.31253690 |
| 88 | CNS hypomyelination (HP:0003429) | 2.31230206 |
| 89 | Shawl scrotum (HP:0000049) | 2.31108395 |
| 90 | Facial hemangioma (HP:0000329) | 2.29899118 |
| 91 | Abnormal mitochondria in muscle tissue (HP:0008316) | 2.29785477 |
| 92 | Multiple enchondromatosis (HP:0005701) | 2.28731344 |
| 93 | Hamartoma of the eye (HP:0010568) | 2.28469611 |
| 94 | Missing ribs (HP:0000921) | 2.27545198 |
| 95 | Progressive muscle weakness (HP:0003323) | 2.27262402 |
| 96 | Atrophy/Degeneration involving motor neurons (HP:0007373) | 2.26111460 |
| 97 | Conjunctival hamartoma (HP:0100780) | 2.26106451 |
| 98 | Neoplasm of the adrenal gland (HP:0100631) | 2.24518963 |
| 99 | Generalized hypopigmentation (HP:0007513) | 2.23898848 |
| 100 | Trismus (HP:0000211) | 2.23566812 |
| 101 | Abdominal situs inversus (HP:0003363) | 2.22168727 |
| 102 | Abnormality of abdominal situs (HP:0011620) | 2.22168727 |
| 103 | Duodenal stenosis (HP:0100867) | 2.22126363 |
| 104 | Small intestinal stenosis (HP:0012848) | 2.22126363 |
| 105 | Prominent nose (HP:0000448) | 2.21741663 |
| 106 | Secondary amenorrhea (HP:0000869) | 2.21253592 |
| 107 | Bone marrow hypocellularity (HP:0005528) | 2.20208058 |
| 108 | Increased serum lactate (HP:0002151) | 2.19876803 |
| 109 | Basal cell carcinoma (HP:0002671) | 2.18163329 |
| 110 | Abnormality of the fetal cardiovascular system (HP:0010948) | 2.17796821 |
| 111 | Abnormal umbilical cord blood vessels (HP:0011403) | 2.17796821 |
| 112 | Single umbilical artery (HP:0001195) | 2.17796821 |
| 113 | Congenital stationary night blindness (HP:0007642) | 2.16554060 |
| 114 | Clubbing of toes (HP:0100760) | 2.16065500 |
| 115 | Myelodysplasia (HP:0002863) | 2.14353858 |
| 116 | Metaphyseal cupping (HP:0003021) | 2.13510527 |
| 117 | Sparse lateral eyebrow (HP:0005338) | 2.12871755 |
| 118 | Tongue fasciculations (HP:0001308) | 2.11753690 |
| 119 | Biliary tract neoplasm (HP:0100574) | 2.10933636 |
| 120 | Neoplasm of the oral cavity (HP:0100649) | 2.10533199 |
| 121 | Neoplasm of striated muscle (HP:0009728) | 2.08152181 |
| 122 | Tracheoesophageal fistula (HP:0002575) | 2.05698246 |
| 123 | Mitochondrial inheritance (HP:0001427) | 2.04561024 |
| 124 | Nephroblastoma (Wilms tumor) (HP:0002667) | 2.04251161 |
| 125 | Facial cleft (HP:0002006) | 2.03783097 |
| 126 | Hypokinesia (HP:0002375) | 2.03671727 |
| 127 | Hepatocellular necrosis (HP:0001404) | 2.02874293 |
| 128 | Reduced subcutaneous adipose tissue (HP:0003758) | 2.02872159 |
| 129 | Blue irides (HP:0000635) | 2.02230973 |
| 130 | Premature graying of hair (HP:0002216) | 2.01739140 |
| 131 | Meningioma (HP:0002858) | 2.01235304 |
| 132 | Palpitations (HP:0001962) | 2.00576825 |
| 133 | Breast carcinoma (HP:0003002) | 2.00151186 |
| 134 | Cellular immunodeficiency (HP:0005374) | 2.00068432 |
| 135 | Horizontal nystagmus (HP:0000666) | 1.99932344 |
| 136 | Onycholysis (HP:0001806) | 1.99871996 |
| 137 | Proximal placement of thumb (HP:0009623) | 1.99347739 |
| 138 | Aplastic anemia (HP:0001915) | 1.98490462 |
| 139 | Neoplasm of the adrenal cortex (HP:0100641) | 1.98474880 |
| 140 | Pallor (HP:0000980) | 1.96834585 |
| 141 | Aplasia/Hypoplasia of the sacrum (HP:0008517) | 1.95772877 |
| 142 | Personality changes (HP:0000751) | 1.95665074 |
| 143 | Muscle fibrillation (HP:0010546) | 1.95351772 |
| 144 | Hypoplasia of the radius (HP:0002984) | 1.94747855 |
| 145 | Squamous cell carcinoma (HP:0002860) | 1.94534681 |
| 146 | Hypopigmentation of the fundus (HP:0007894) | 1.94113806 |
| 147 | Abnormality of glycine metabolism (HP:0010895) | 1.93758820 |
| 148 | Abnormality of serine family amino acid metabolism (HP:0010894) | 1.93758820 |
| 149 | Melanoma (HP:0002861) | 1.93240455 |
| 150 | Entropion (HP:0000621) | 1.93036254 |
| 151 | Sloping forehead (HP:0000340) | 1.92974305 |
| 152 | Increased hepatocellular lipid droplets (HP:0006565) | 1.92449442 |
| 153 | Embryonal renal neoplasm (HP:0011794) | 1.92374008 |
| 154 | Pancreatic islet-cell hyperplasia (HP:0004510) | 1.92155828 |
| 155 | Short thumb (HP:0009778) | 1.92082005 |
| 156 | Pili torti (HP:0003777) | 1.92036638 |
| 157 | Cerebral edema (HP:0002181) | 1.92010661 |
| 158 | Abnormality of pyrimidine metabolism (HP:0004353) | 1.91550307 |
| 159 | Aplasia/Hypoplasia involving the musculature (HP:0001460) | 1.90424256 |
| 160 | Abnormal number of incisors (HP:0011064) | 1.89433536 |
| 161 | Anal stenosis (HP:0002025) | 1.88915865 |
| 162 | Abnormality of the umbilical cord (HP:0010881) | 1.88700359 |
| 163 | Breast aplasia (HP:0100783) | 1.88147241 |
| 164 | Deviation of the thumb (HP:0009603) | 1.86879495 |
| 165 | Abnormalities of placenta or umbilical cord (HP:0001194) | 1.86464294 |
| 166 | Stillbirth (HP:0003826) | 1.85540287 |
| 167 | Abnormality of the duodenum (HP:0002246) | 1.84228701 |
| 168 | Abnormality of sulfur amino acid metabolism (HP:0004339) | 1.83658597 |
| 169 | Hepatic necrosis (HP:0002605) | 1.83473958 |
| 170 | Microglossia (HP:0000171) | 1.80426088 |
| 171 | Aplasia cutis congenita (HP:0001057) | 1.74918881 |
| 172 | Decreased central vision (HP:0007663) | 1.72711077 |
| 173 | Neoplasm of the peripheral nervous system (HP:0100007) | 1.70457318 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | BUB1 | 5.42472446 |
| 2 | WEE1 | 5.29151028 |
| 3 | TRIM28 | 3.85960962 |
| 4 | ACVR1B | 3.37735060 |
| 5 | CDC7 | 3.36097539 |
| 6 | TSSK6 | 3.06262051 |
| 7 | EIF2AK1 | 2.95946658 |
| 8 | EPHA2 | 2.88303044 |
| 9 | NEK2 | 2.76332154 |
| 10 | SIK3 | 2.73284203 |
| 11 | MST1R | 2.72877327 |
| 12 | TTK | 2.64637061 |
| 13 | NEK1 | 2.46884345 |
| 14 | SRPK1 | 2.37367279 |
| 15 | VRK2 | 2.31532911 |
| 16 | AKT3 | 2.19817960 |
| 17 | PLK4 | 2.17229938 |
| 18 | PLK1 | 2.08982030 |
| 19 | PNCK | 2.00944961 |
| 20 | STK39 | 1.98947726 |
| 21 | PBK | 1.97090968 |
| 22 | BMPR1B | 1.93642218 |
| 23 | NUAK1 | 1.91230318 |
| 24 | CDK12 | 1.87537760 |
| 25 | CDK7 | 1.82474442 |
| 26 | ERBB3 | 1.81080534 |
| 27 | MKNK1 | 1.79245499 |
| 28 | MKNK2 | 1.78206917 |
| 29 | BRSK2 | 1.78199043 |
| 30 | RPS6KB2 | 1.67868900 |
| 31 | PLK3 | 1.64750191 |
| 32 | BCR | 1.59985787 |
| 33 | TAF1 | 1.54108228 |
| 34 | CHEK2 | 1.52246889 |
| 35 | AURKB | 1.51084263 |
| 36 | EIF2AK3 | 1.49004770 |
| 37 | FRK | 1.42080341 |
| 38 | STK16 | 1.41518725 |
| 39 | ATR | 1.39639714 |
| 40 | DYRK3 | 1.39018701 |
| 41 | NME2 | 1.38533861 |
| 42 | CDK4 | 1.32184002 |
| 43 | PLK2 | 1.30690674 |
| 44 | AURKA | 1.29498177 |
| 45 | TESK2 | 1.27494662 |
| 46 | EEF2K | 1.26729840 |
| 47 | OXSR1 | 1.26291836 |
| 48 | MAP3K12 | 1.25987214 |
| 49 | FER | 1.22077005 |
| 50 | ALK | 1.20453188 |
| 51 | CHEK1 | 1.20029822 |
| 52 | MAP3K8 | 1.16612759 |
| 53 | PDK3 | 1.15191267 |
| 54 | PDK4 | 1.15191267 |
| 55 | VRK1 | 1.13867807 |
| 56 | STK38L | 1.08611348 |
| 57 | PASK | 1.08015050 |
| 58 | PDK2 | 1.07309967 |
| 59 | TNIK | 1.07215210 |
| 60 | LATS2 | 1.06337446 |
| 61 | MET | 1.06191725 |
| 62 | BRSK1 | 1.03158171 |
| 63 | STK10 | 0.99147990 |
| 64 | RPS6KA4 | 0.95609535 |
| 65 | PRKCI | 0.93741207 |
| 66 | ERBB4 | 0.93230585 |
| 67 | CDK2 | 0.89956965 |
| 68 | SCYL2 | 0.88903907 |
| 69 | TLK1 | 0.88681455 |
| 70 | PIM1 | 0.88340081 |
| 71 | PAK4 | 0.86499572 |
| 72 | TGFBR1 | 0.84824293 |
| 73 | ATM | 0.79162249 |
| 74 | MST4 | 0.77556018 |
| 75 | PAK1 | 0.74531030 |
| 76 | CSNK2A2 | 0.71459948 |
| 77 | CCNB1 | 0.68619347 |
| 78 | CLK1 | 0.67367008 |
| 79 | INSRR | 0.65952948 |
| 80 | CSNK1E | 0.65767813 |
| 81 | ZAK | 0.65199588 |
| 82 | TGFBR2 | 0.63456041 |
| 83 | CDK1 | 0.61038265 |
| 84 | DAPK1 | 0.60923215 |
| 85 | CSNK2A1 | 0.59174955 |
| 86 | MELK | 0.58907878 |
| 87 | STK3 | 0.58725471 |
| 88 | MARK3 | 0.58580646 |
| 89 | KDR | 0.58547404 |
| 90 | IRAK3 | 0.57814264 |
| 91 | MTOR | 0.56874175 |
| 92 | BRD4 | 0.56102961 |
| 93 | BMPR2 | 0.55687255 |
| 94 | MAPKAPK5 | 0.54337393 |
| 95 | STK4 | 0.50286527 |
| 96 | MAPKAPK3 | 0.50182455 |
| 97 | CSNK1G2 | 0.49966082 |
| 98 | GRK6 | 0.46479974 |
| 99 | CSNK1G1 | 0.46050432 |
| 100 | ILK | 0.45702704 |
| 101 | FGFR1 | 0.45519338 |
| 102 | NME1 | 0.45170723 |
| 103 | AKT2 | 0.43991935 |
| 104 | BRAF | 0.43909632 |
| 105 | CSNK1G3 | 0.43575132 |
| 106 | PIK3CA | 0.41978332 |
| 107 | MAP2K2 | 0.41308697 |
| 108 | EIF2AK2 | 0.41003330 |
| 109 | LIMK1 | 0.40691787 |
| 110 | CDK6 | 0.39046748 |
| 111 | PTK2B | 0.37540415 |
| 112 | FLT3 | 0.36627472 |
| 113 | PTK2 | 0.35814908 |
| 114 | GRK1 | 0.34801344 |
| 115 | MAP4K1 | 0.34533716 |
| 116 | MAP3K11 | 0.33505881 |
| 117 | BCKDK | 0.31505347 |
| 118 | SMG1 | 0.31225371 |
| 119 | DYRK2 | 0.30315449 |
| 120 | TAOK1 | 0.29167716 |
| 121 | PAK2 | 0.28554931 |
| 122 | CSNK1D | 0.27833287 |
| 123 | PRKDC | 0.27670008 |
| 124 | GSK3A | 0.27649166 |
| 125 | RPS6KA5 | 0.27388526 |
| 126 | LMTK2 | 0.27144473 |
| 127 | MINK1 | 0.25892541 |
| 128 | GRK5 | 0.25841177 |
| 129 | CDK8 | 0.25562984 |
| 130 | NLK | 0.25037893 |
| 131 | LATS1 | 0.24081038 |
| 132 | PIM2 | 0.22319578 |
| 133 | MAPK14 | 0.21620316 |
| 134 | CSNK1A1L | 0.20613571 |
| 135 | GSK3B | 0.20603375 |
| 136 | MAP3K3 | 0.19889865 |
| 137 | WNK3 | 0.19823206 |
| 138 | LRRK2 | 0.18521231 |
| 139 | STK24 | 0.18464767 |
| 140 | RAF1 | 0.18248692 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008 | 4.57517384 |
| 2 | DNA replication_Homo sapiens_hsa03030 | 4.19485854 |
| 3 | Mismatch repair_Homo sapiens_hsa03430 | 3.93578700 |
| 4 | RNA polymerase_Homo sapiens_hsa03020 | 3.87198350 |
| 5 | RNA transport_Homo sapiens_hsa03013 | 3.56562367 |
| 6 | Spliceosome_Homo sapiens_hsa03040 | 3.27522890 |
| 7 | Proteasome_Homo sapiens_hsa03050 | 3.25342450 |
| 8 | Ribosome_Homo sapiens_hsa03010 | 2.99242725 |
| 9 | Protein export_Homo sapiens_hsa03060 | 2.70844603 |
| 10 | Nucleotide excision repair_Homo sapiens_hsa03420 | 2.67712974 |
| 11 | Homologous recombination_Homo sapiens_hsa03440 | 2.66023837 |
| 12 | Base excision repair_Homo sapiens_hsa03410 | 2.65781597 |
| 13 | Vitamin B6 metabolism_Homo sapiens_hsa00750 | 2.63721156 |
| 14 | Cell cycle_Homo sapiens_hsa04110 | 2.62098773 |
| 15 | One carbon pool by folate_Homo sapiens_hsa00670 | 2.50576141 |
| 16 | Pyrimidine metabolism_Homo sapiens_hsa00240 | 2.50440152 |
| 17 | Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970 | 2.37343072 |
| 18 | Basal transcription factors_Homo sapiens_hsa03022 | 2.15094505 |
| 19 | Fanconi anemia pathway_Homo sapiens_hsa03460 | 2.08125379 |
| 20 | mRNA surveillance pathway_Homo sapiens_hsa03015 | 1.78485671 |
| 21 | RNA degradation_Homo sapiens_hsa03018 | 1.74153052 |
| 22 | p53 signaling pathway_Homo sapiens_hsa04115 | 1.69535654 |
| 23 | Folate biosynthesis_Homo sapiens_hsa00790 | 1.68699694 |
| 24 | Propanoate metabolism_Homo sapiens_hsa00640 | 1.54250873 |
| 25 | Purine metabolism_Homo sapiens_hsa00230 | 1.45218536 |
| 26 | Fatty acid elongation_Homo sapiens_hsa00062 | 1.44249086 |
| 27 | Non-homologous end-joining_Homo sapiens_hsa03450 | 1.42082182 |
| 28 | Pyruvate metabolism_Homo sapiens_hsa00620 | 1.38539598 |
| 29 | Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770 | 1.36584845 |
| 30 | N-Glycan biosynthesis_Homo sapiens_hsa00510 | 1.30221728 |
| 31 | Sulfur metabolism_Homo sapiens_hsa00920 | 1.29477096 |
| 32 | Cysteine and methionine metabolism_Homo sapiens_hsa00270 | 1.27783707 |
| 33 | Parkinsons disease_Homo sapiens_hsa05012 | 1.27228930 |
| 34 | Pentose phosphate pathway_Homo sapiens_hsa00030 | 1.25320389 |
| 35 | Vitamin digestion and absorption_Homo sapiens_hsa04977 | 1.24446893 |
| 36 | Biosynthesis of amino acids_Homo sapiens_hsa01230 | 1.24410515 |
| 37 | Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa00520 | 1.23486023 |
| 38 | Cyanoamino acid metabolism_Homo sapiens_hsa00460 | 1.22846437 |
| 39 | Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130 | 1.21878341 |
| 40 | Oocyte meiosis_Homo sapiens_hsa04114 | 1.21429598 |
| 41 | Oxidative phosphorylation_Homo sapiens_hsa00190 | 1.20360297 |
| 42 | Epstein-Barr virus infection_Homo sapiens_hsa05169 | 1.16704339 |
| 43 | Glycine, serine and threonine metabolism_Homo sapiens_hsa00260 | 1.14622370 |
| 44 | Ubiquitin mediated proteolysis_Homo sapiens_hsa04120 | 1.07720949 |
| 45 | Progesterone-mediated oocyte maturation_Homo sapiens_hsa04914 | 1.01261011 |
| 46 | Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280 | 0.97110906 |
| 47 | Steroid biosynthesis_Homo sapiens_hsa00100 | 0.96838048 |
| 48 | Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533 | 0.96461841 |
| 49 | Fructose and mannose metabolism_Homo sapiens_hsa00051 | 0.90427578 |
| 50 | Antigen processing and presentation_Homo sapiens_hsa04612 | 0.89818182 |
| 51 | Regulation of autophagy_Homo sapiens_hsa04140 | 0.87129234 |
| 52 | Drug metabolism - other enzymes_Homo sapiens_hsa00983 | 0.86496460 |
| 53 | Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623 | 0.84786455 |
| 54 | Selenocompound metabolism_Homo sapiens_hsa00450 | 0.84334550 |
| 55 | 2-Oxocarboxylic acid metabolism_Homo sapiens_hsa01210 | 0.78896627 |
| 56 | Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860 | 0.78887127 |
| 57 | Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630 | 0.78065807 |
| 58 | Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512 | 0.75705029 |
| 59 | Viral carcinogenesis_Homo sapiens_hsa05203 | 0.73896581 |
| 60 | Alzheimers disease_Homo sapiens_hsa05010 | 0.68237244 |
| 61 | Glutathione metabolism_Homo sapiens_hsa00480 | 0.65972126 |
| 62 | Glycerophospholipid metabolism_Homo sapiens_hsa00564 | 0.65558294 |
| 63 | Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601 | 0.65023860 |
| 64 | Carbon metabolism_Homo sapiens_hsa01200 | 0.64275927 |
| 65 | Herpes simplex infection_Homo sapiens_hsa05168 | 0.63386013 |
| 66 | Sulfur relay system_Homo sapiens_hsa04122 | 0.63338530 |
| 67 | Thyroid cancer_Homo sapiens_hsa05216 | 0.63069058 |
| 68 | Sphingolipid metabolism_Homo sapiens_hsa00600 | 0.60194963 |
| 69 | Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa04550 | 0.57615984 |
| 70 | Pentose and glucuronate interconversions_Homo sapiens_hsa00040 | 0.55126452 |
| 71 | Renin-angiotensin system_Homo sapiens_hsa04614 | 0.53264104 |
| 72 | HTLV-I infection_Homo sapiens_hsa05166 | 0.49452140 |
| 73 | Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072 | 0.49016648 |
| 74 | Systemic lupus erythematosus_Homo sapiens_hsa05322 | 0.47197829 |
| 75 | Tyrosine metabolism_Homo sapiens_hsa00350 | 0.46392997 |
| 76 | Fat digestion and absorption_Homo sapiens_hsa04975 | 0.44191585 |
| 77 | Hippo signaling pathway_Homo sapiens_hsa04390 | 0.44174189 |
| 78 | Galactose metabolism_Homo sapiens_hsa00052 | 0.42841423 |
| 79 | Fatty acid metabolism_Homo sapiens_hsa01212 | 0.42360942 |
| 80 | Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa00250 | 0.42006969 |
| 81 | MicroRNAs in cancer_Homo sapiens_hsa05206 | 0.41824237 |
| 82 | Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932 | 0.41729228 |
| 83 | Peroxisome_Homo sapiens_hsa04146 | 0.38505500 |
| 84 | Mineral absorption_Homo sapiens_hsa04978 | 0.38246837 |
| 85 | beta-Alanine metabolism_Homo sapiens_hsa00410 | 0.37215017 |
| 86 | Terpenoid backbone biosynthesis_Homo sapiens_hsa00900 | 0.36397794 |
| 87 | Arginine and proline metabolism_Homo sapiens_hsa00330 | 0.35914818 |
| 88 | Butirosin and neomycin biosynthesis_Homo sapiens_hsa00524 | 0.35780296 |
| 89 | Tight junction_Homo sapiens_hsa04530 | 0.30799613 |
| 90 | Small cell lung cancer_Homo sapiens_hsa05222 | 0.30617626 |
| 91 | mTOR signaling pathway_Homo sapiens_hsa04150 | 0.28684074 |
| 92 | SNARE interactions in vesicular transport_Homo sapiens_hsa04130 | 0.28230930 |
| 93 | Glycerolipid metabolism_Homo sapiens_hsa00561 | 0.28019694 |
| 94 | Metabolic pathways_Homo sapiens_hsa01100 | 0.27452182 |
| 95 | HIF-1 signaling pathway_Homo sapiens_hsa04066 | 0.27227827 |
| 96 | Vibrio cholerae infection_Homo sapiens_hsa05110 | 0.25506035 |
| 97 | TGF-beta signaling pathway_Homo sapiens_hsa04350 | 0.25215319 |
| 98 | Glycolysis / Gluconeogenesis_Homo sapiens_hsa00010 | 0.24699148 |
| 99 | Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa01040 | 0.24404681 |
| 100 | Primary immunodeficiency_Homo sapiens_hsa05340 | 0.23045530 |
| 101 | Pathogenic Escherichia coli infection_Homo sapiens_hsa05130 | 0.21554818 |
| 102 | Shigellosis_Homo sapiens_hsa05131 | 0.21391644 |
| 103 | Transcriptional misregulation in cancer_Homo sapiens_hsa05202 | 0.20756574 |
| 104 | Legionellosis_Homo sapiens_hsa05134 | 0.19505234 |
| 105 | Bacterial invasion of epithelial cells_Homo sapiens_hsa05100 | 0.19348317 |
| 106 | Caffeine metabolism_Homo sapiens_hsa00232 | 0.19042534 |
| 107 | Starch and sucrose metabolism_Homo sapiens_hsa00500 | 0.18545041 |
| 108 | Central carbon metabolism in cancer_Homo sapiens_hsa05230 | 0.17287099 |
| 109 | Colorectal cancer_Homo sapiens_hsa05210 | 0.17233930 |
| 110 | Apoptosis_Homo sapiens_hsa04210 | 0.16932947 |
| 111 | Hedgehog signaling pathway_Homo sapiens_hsa04340 | 0.15681852 |
| 112 | Notch signaling pathway_Homo sapiens_hsa04330 | 0.15596052 |
| 113 | Basal cell carcinoma_Homo sapiens_hsa05217 | 0.15213373 |
| 114 | Protein processing in endoplasmic reticulum_Homo sapiens_hsa04141 | 0.12795377 |
| 115 | Tryptophan metabolism_Homo sapiens_hsa00380 | 0.12322249 |
| 116 | Adherens junction_Homo sapiens_hsa04520 | 0.12161324 |
| 117 | Citrate cycle (TCA cycle)_Homo sapiens_hsa00020 | 0.11993809 |
| 118 | Wnt signaling pathway_Homo sapiens_hsa04310 | 0.11778143 |
| 119 | Fatty acid degradation_Homo sapiens_hsa00071 | 0.11268844 |
| 120 | Proteoglycans in cancer_Homo sapiens_hsa05205 | 0.10523187 |
| 121 | Huntingtons disease_Homo sapiens_hsa05016 | 0.10225139 |
| 122 | Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760 | 0.08928982 |
| 123 | Pathways in cancer_Homo sapiens_hsa05200 | 0.08712845 |
| 124 | Arachidonic acid metabolism_Homo sapiens_hsa00590 | 0.08340179 |
| 125 | Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563 | 0.08284671 |
| 126 | FoxO signaling pathway_Homo sapiens_hsa04068 | 0.07796921 |
| 127 | Prostate cancer_Homo sapiens_hsa05215 | 0.07737896 |
| 128 | Thyroid hormone signaling pathway_Homo sapiens_hsa04919 | 0.06511821 |
| 129 | alpha-Linolenic acid metabolism_Homo sapiens_hsa00592 | 0.04189373 |
| 130 | Bladder cancer_Homo sapiens_hsa05219 | 0.03805635 |
| 131 | Circadian rhythm_Homo sapiens_hsa04710 | 0.03754406 |
| 132 | Acute myeloid leukemia_Homo sapiens_hsa05221 | 0.02356459 |
| 133 | Linoleic acid metabolism_Homo sapiens_hsa00591 | 0.01976388 |
| 134 | Longevity regulating pathway - mammal_Homo sapiens_hsa04211 | 0.00594470 |
| 135 | NOD-like receptor signaling pathway_Homo sapiens_hsa04621 | -0.0066791 |

