Rank | Gene Set | Z-score |
---|---|---|
1 | sperm motility (GO:0030317) | 9.98171189 |
2 | acrosome reaction (GO:0007340) | 9.71078050 |
3 | fusion of sperm to egg plasma membrane (GO:0007342) | 8.93045510 |
4 | microtubule depolymerization (GO:0007019) | 8.08016088 |
5 | response to pheromone (GO:0019236) | 7.85825495 |
6 | chromosome condensation (GO:0030261) | 7.44779342 |
7 | spermatid development (GO:0007286) | 7.38660058 |
8 | single strand break repair (GO:0000012) | 7.27167380 |
9 | sperm capacitation (GO:0048240) | 7.22402346 |
10 | DNA packaging (GO:0006323) | 7.22239747 |
11 | negative regulation of inclusion body assembly (GO:0090084) | 6.89454573 |
12 | plasma membrane fusion (GO:0045026) | 6.72226619 |
13 | spermatid nucleus differentiation (GO:0007289) | 6.33758056 |
14 | multicellular organism reproduction (GO:0032504) | 6.29497308 |
15 | cellular ketone body metabolic process (GO:0046950) | 6.22334208 |
16 | protein polyglutamylation (GO:0018095) | 6.03732861 |
17 | microtubule polymerization or depolymerization (GO:0031109) | 5.94868319 |
18 | reproduction (GO:0000003) | 5.90321373 |
19 | sperm-egg recognition (GO:0035036) | 5.89325257 |
20 | sexual reproduction (GO:0019953) | 5.68970834 |
21 | phosphatidylethanolamine biosynthetic process (GO:0006646) | 5.45897297 |
22 | ketone body metabolic process (GO:1902224) | 5.45475942 |
23 | rRNA methylation (GO:0031167) | 5.38952331 |
24 | spermatogenesis (GO:0007283) | 5.27980028 |
25 | male gamete generation (GO:0048232) | 5.26970375 |
26 | calcium ion-dependent exocytosis (GO:0017156) | 5.11861132 |
27 | cell-cell recognition (GO:0009988) | 5.09931671 |
28 | antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G | 4.97740419 |
29 | protein targeting to Golgi (GO:0000042) | 4.92696948 |
30 | phosphatidylethanolamine metabolic process (GO:0046337) | 4.92326767 |
31 | binding of sperm to zona pellucida (GO:0007339) | 4.92269082 |
32 | glomerular visceral epithelial cell development (GO:0072015) | 4.91967749 |
33 | gamete generation (GO:0007276) | 4.82274236 |
34 | axonemal dynein complex assembly (GO:0070286) | 4.81949038 |
35 | establishment of protein localization to Golgi (GO:0072600) | 4.80272199 |
36 | retrograde transport, vesicle recycling within Golgi (GO:0000301) | 4.76049675 |
37 | positive regulation of Rab GTPase activity (GO:0032851) | 4.75835375 |
38 | regulation of Rab GTPase activity (GO:0032313) | 4.75835375 |
39 | cilium or flagellum-dependent cell motility (GO:0001539) | 4.64285979 |
40 | coenzyme catabolic process (GO:0009109) | 4.60698713 |
41 | rRNA modification (GO:0000154) | 4.60496960 |
42 | glomerular epithelial cell development (GO:0072310) | 4.50699041 |
43 | growth hormone secretion (GO:0030252) | 4.49705281 |
44 | motile cilium assembly (GO:0044458) | 4.42888814 |
45 | centriole replication (GO:0007099) | 4.41862211 |
46 | RNA destabilization (GO:0050779) | 4.40641011 |
47 | microtubule severing (GO:0051013) | 4.27425695 |
48 | regulation of gamma-delta T cell differentiation (GO:0045586) | 4.21023924 |
49 | regulation of inclusion body assembly (GO:0090083) | 4.17196016 |
50 | chromatin silencing (GO:0006342) | 4.16151316 |
51 | single fertilization (GO:0007338) | 4.15757481 |
52 | germ cell development (GO:0007281) | 4.04023634 |
53 | multicellular organismal reproductive process (GO:0048609) | 3.97728771 |
54 | seminiferous tubule development (GO:0072520) | 3.91520372 |
55 | protein localization to Golgi apparatus (GO:0034067) | 3.90608667 |
56 | organic cation transport (GO:0015695) | 3.87282311 |
57 | centriole assembly (GO:0098534) | 3.83354998 |
58 | positive regulation of growth hormone secretion (GO:0060124) | 3.81875612 |
59 | cellular process involved in reproduction in multicellular organism (GO:0022412) | 3.62080692 |
60 | regulation of transcription involved in cell fate commitment (GO:0060850) | 3.52965827 |
61 | regulation of cilium movement (GO:0003352) | 3.52551108 |
62 | regulation of centriole replication (GO:0046599) | 3.48931176 |
63 | nucleus organization (GO:0006997) | 3.48258867 |
64 | fertilization (GO:0009566) | 3.47484246 |
65 | determination of adult lifespan (GO:0008340) | 3.45076930 |
66 | negative regulation of Rho protein signal transduction (GO:0035024) | 3.44324699 |
67 | regulation of somitogenesis (GO:0014807) | 3.43911266 |
68 | musculoskeletal movement (GO:0050881) | 3.43829646 |
69 | multicellular organismal movement (GO:0050879) | 3.43829646 |
70 | urinary tract smooth muscle contraction (GO:0014848) | 3.43657516 |
71 | regulation of gamma-delta T cell activation (GO:0046643) | 3.41659186 |
72 | mesonephros development (GO:0001823) | 3.29688558 |
73 | urogenital system development (GO:0001655) | 3.29670715 |
74 | endothelial cell chemotaxis (GO:0035767) | 3.24468080 |
75 | protein depolymerization (GO:0051261) | 3.23357950 |
76 | behavioral response to nicotine (GO:0035095) | 3.10448494 |
77 | regulation of growth hormone secretion (GO:0060123) | 3.05987402 |
78 | negative regulation of gene expression, epigenetic (GO:0045814) | 3.01203223 |
79 | cell wall macromolecule catabolic process (GO:0016998) | 2.97575672 |
80 | positive regulation of T cell mediated cytotoxicity (GO:0001916) | 2.93889370 |
81 | male meiosis I (GO:0007141) | 2.86249124 |
82 | cartilage development involved in endochondral bone morphogenesis (GO:0060351) | 2.85732254 |
83 | multicellular organismal development (GO:0007275) | 2.84082713 |
84 | epithelial cilium movement (GO:0003351) | 2.83021880 |
85 | peptidyl-threonine dephosphorylation (GO:0035970) | 2.83015268 |
86 | negative regulation of mesenchymal cell apoptotic process (GO:2001054) | 2.82247495 |
87 | cell wall macromolecule metabolic process (GO:0044036) | 2.81827653 |
88 | homeostasis of number of cells within a tissue (GO:0048873) | 2.81711531 |
89 | regulation of insulin-like growth factor receptor signaling pathway (GO:0043567) | 2.80901975 |
90 | positive regulation of insulin-like growth factor receptor signaling pathway (GO:0043568) | 2.79982549 |
91 | neuromuscular synaptic transmission (GO:0007274) | 2.78768848 |
92 | positive regulation of endothelial cell differentiation (GO:0045603) | 2.78525642 |
93 | estrogen biosynthetic process (GO:0006703) | 2.76977198 |
94 | protein K48-linked deubiquitination (GO:0071108) | 2.76839419 |
95 | membrane protein intracellular domain proteolysis (GO:0031293) | 2.72551028 |
96 | left/right axis specification (GO:0070986) | 2.70637978 |
97 | regulation of female gonad development (GO:2000194) | 2.68418420 |
98 | mitochondrial fission (GO:0000266) | 2.68143710 |
99 | mitotic G1/S transition checkpoint (GO:0044819) | 2.66759851 |
100 | tRNA methylation (GO:0030488) | 2.64843565 |
Rank | Gene Set | Z-score |
---|---|---|
1 | MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human | 4.72754378 |
2 | SOX9_22984422_ChIP-ChIP_TESTIS_Rat | 4.05798846 |
3 | STAT6_21828071_ChIP-Seq_BEAS2B_Human | 3.93098104 |
4 | TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat | 3.65656874 |
5 | FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse | 2.61917530 |
6 | DROSHA_22980978_ChIP-Seq_HELA_Human | 2.45239160 |
7 | EZH2_22144423_ChIP-Seq_EOC_Human | 2.35666815 |
8 | ERA_21632823_ChIP-Seq_H3396_Human | 2.14796952 |
9 | RBPJ_21746931_ChIP-Seq_IB4-LCL_Human | 2.09605323 |
10 | RAC3_21632823_ChIP-Seq_H3396_Human | 2.04354524 |
11 | GLI1_17442700_ChIP-ChIP_MESCs_Mouse | 2.01012868 |
12 | VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human | 1.97627951 |
13 | EBNA2_21746931_ChIP-Seq_IB4-LCL_Human | 1.96988322 |
14 | YY1_22570637_ChIP-Seq_MALME-3M_Human | 1.96671498 |
15 | WDR5_24793694_ChIP-Seq_LNCAP_Human | 1.96159190 |
16 | BCL6_27268052_Chip-Seq_Bcells_Human | 1.93786690 |
17 | CTCF_27219007_Chip-Seq_Bcells_Human | 1.93698469 |
18 | TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse | 1.90846393 |
19 | POU5F1_26923725_Chip-Seq_MESODERM_Mouse | 1.90846393 |
20 | E2F1_20622854_ChIP-Seq_HELA_Human | 1.87511897 |
21 | PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse | 1.84192433 |
22 | CTBP2_25329375_ChIP-Seq_LNCAP_Human | 1.82957635 |
23 | P68_20966046_ChIP-Seq_HELA_Human | 1.82564387 |
24 | EBNA1_20929547_Chip-Seq_RAJI-cells_Human | 1.79489904 |
25 | BCOR_27268052_Chip-Seq_Bcells_Human | 1.78719783 |
26 | SMC4_20622854_ChIP-Seq_HELA_Human | 1.69743435 |
27 | ELF1_20517297_ChIP-Seq_JURKAT_Human | 1.66418177 |
28 | ER_23166858_ChIP-Seq_MCF-7_Human | 1.65455453 |
29 | EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human | 1.62675295 |
30 | TDRD3_21172665_ChIP-Seq_MCF-7_Human | 1.60665224 |
31 | PHF8_20622854_ChIP-Seq_HELA_Human | 1.60555007 |
32 | CTBP1_25329375_ChIP-Seq_LNCAP_Human | 1.59494486 |
33 | NANOG_20526341_ChIP-Seq_ESCs_Human | 1.58423590 |
34 | P63_20808887_ChIP-Seq_KERATINOCYTES_Human | 1.56129386 |
35 | OCT4_20526341_ChIP-Seq_ESCs_Human | 1.55212567 |
36 | LXR_22292898_ChIP-Seq_THP-1_Human | 1.54712747 |
37 | GATA3_21878914_ChIP-Seq_MCF-7_Human | 1.54178312 |
38 | CBP_20019798_ChIP-Seq_JUKART_Human | 1.53417275 |
39 | IRF4_20064451_ChIP-Seq_CD4+T_Mouse | 1.53417275 |
40 | TP63_22573176_ChIP-Seq_HFKS_Human | 1.52164246 |
41 | TAF2_19829295_ChIP-Seq_ESCs_Human | 1.52164049 |
42 | RUNX_20019798_ChIP-Seq_JUKART_Human | 1.47760818 |
43 | CTCF_20526341_ChIP-Seq_ESCs_Human | 1.47636615 |
44 | SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human | 1.43027947 |
45 | SUZ12_27294783_Chip-Seq_ESCs_Mouse | 1.42844578 |
46 | P300_27268052_Chip-Seq_Bcells_Human | 1.41001610 |
47 | MYC_19829295_ChIP-Seq_ESCs_Human | 1.37568985 |
48 | ZNF274_21170338_ChIP-Seq_K562_Hela | 1.33226541 |
49 | SA1_27219007_Chip-Seq_Bcells_Human | 1.32049315 |
50 | SMAD2/3_21741376_ChIP-Seq_ESCs_Human | 1.29254304 |
51 | EZH2_27294783_Chip-Seq_ESCs_Mouse | 1.28128776 |
52 | ARNT_22903824_ChIP-Seq_MCF-7_Human | 1.27836914 |
53 | CEBPB_22108803_ChIP-Seq_LS180_Human | 1.27519252 |
54 | CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human | 1.23691941 |
55 | JARID2_20075857_ChIP-Seq_MESCs_Mouse | 1.23516654 |
56 | AUTS2_25519132_ChIP-Seq_293T-REX_Human | 1.23414162 |
57 | GATA1_19941826_ChIP-Seq_K562_Human | 1.21860549 |
58 | SMAD2/3_21741376_ChIP-Seq_EPCs_Human | 1.20146069 |
59 | P53_21459846_ChIP-Seq_SAOS-2_Human | 1.20001518 |
60 | SMAD4_21741376_ChIP-Seq_EPCs_Human | 1.19954544 |
61 | PBX1_22567123_ChIP-ChIP_OVCAR3_Human | 1.19702616 |
62 | ZNF652_21678463_ChIP-ChIP_ZR75-1_Human | 1.18916625 |
63 | PPARD_23208498_ChIP-Seq_MDA-MB-231_Human | 1.18758805 |
64 | JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human | 1.17526325 |
65 | ERG_20517297_ChIP-Seq_VCAP_Human | 1.16925401 |
66 | DMRT1_21621532_ChIP-ChIP_FETAL_Ovary | 1.15938377 |
67 | UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human | 1.15574034 |
68 | TP53_18474530_ChIP-ChIP_U2OS_Human | 1.12986199 |
69 | CSB_26484114_Chip-Seq_FIBROBLAST_Human | 1.11476297 |
70 | EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human | 1.11432147 |
71 | SOX2_22085726_ChIP-Seq_NPCs_Mouse | 1.09872887 |
72 | KLF4_19829295_ChIP-Seq_ESCs_Human | 1.09282935 |
73 | CBX2_22325352_ChIP-Seq_293T-Rex_Human | 1.09106434 |
74 | HOXB7_26014856_ChIP-Seq_BT474_Human | 1.08870065 |
75 | E2F1_17053090_ChIP-ChIP_MCF-7_Human | 1.08681361 |
76 | RBPJ_21746931_ChIP-Seq_IB4_Human | 1.07472972 |
77 | SPI1_20517297_ChIP-Seq_HL60_Human | 1.06554369 |
78 | HNFA_21074721_ChIP-Seq_CACO-2_Human | 1.06513250 |
79 | ETV2_25802403_ChIP-Seq_MESCs_Mouse | 1.06040446 |
80 | ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human | 1.05587752 |
81 | TP63_19390658_ChIP-ChIP_HaCaT_Human | 1.05144364 |
82 | SMAD3_21741376_ChIP-Seq_ESCs_Human | 1.03567253 |
83 | ETV1_20927104_ChIP-Seq_GIST48_Human | 1.03300910 |
84 | OCT4_19829295_ChIP-Seq_ESCs_Human | 1.02732777 |
85 | EZH2_27304074_Chip-Seq_ESCs_Mouse | 1.01667592 |
86 | NFYB_21822215_ChIP-Seq_K562_Human | 1.01345229 |
87 | PHF8_20622853_ChIP-Seq_HELA_Human | 1.00403848 |
88 | CTCF_21964334_Chip-Seq_Bcells_Human | 0.99462488 |
89 | SMAD3_21741376_ChIP-Seq_EPCs_Human | 0.99435317 |
90 | BP1_19119308_ChIP-ChIP_Hs578T_Human | 0.99115330 |
91 | CDX2_21074721_ChIP-Seq_CACO-2_Mouse | 0.98503839 |
92 | IRF8_22096565_ChIP-ChIP_GC-B_Human | 0.98472915 |
93 | FUS_26573619_Chip-Seq_HEK293_Human | 0.98012623 |
94 | GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human | 0.97587323 |
95 | NCOR_22424771_ChIP-Seq_293T_Human | 0.96663308 |
96 | RUNX1_27514584_Chip-Seq_MCF-7_Human | 0.96255474 |
97 | AR_25329375_ChIP-Seq_VCAP_Human | 0.95240165 |
98 | JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human | 0.95145563 |
99 | GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human | 0.94827159 |
100 | STAT1_20625510_ChIP-Seq_HELA_Human | 0.93301189 |
Rank | Gene Set | Z-score |
---|---|---|
1 | MP0003878_abnormal_ear_physiology | 3.98378704 |
2 | MP0005377_hearing/vestibular/ear_phenot | 3.98378704 |
3 | MP0005670_abnormal_white_adipose | 3.87735363 |
4 | MP0003698_abnormal_male_reproductive | 3.74833257 |
5 | MP0005423_abnormal_somatic_nervous | 3.48377356 |
6 | MP0001929_abnormal_gametogenesis | 3.29510493 |
7 | MP0001348_abnormal_lacrimal_gland | 3.20098317 |
8 | MP0002822_catalepsy | 2.98184836 |
9 | MP0002653_abnormal_ependyma_morphology | 2.80464273 |
10 | MP0003646_muscle_fatigue | 2.61932806 |
11 | MP0002735_abnormal_chemical_nociception | 2.39103775 |
12 | MP0001501_abnormal_sleep_pattern | 2.25335434 |
13 | MP0002161_abnormal_fertility/fecundity | 2.05134332 |
14 | MP0005410_abnormal_fertilization | 10.2819945 |
15 | MP0002132_abnormal_respiratory_system | 1.98258637 |
16 | MP0008961_abnormal_basal_metabolism | 1.92957884 |
17 | MP0003959_abnormal_lean_body | 1.80813822 |
18 | MP0000678_abnormal_parathyroid_gland | 1.66596699 |
19 | MP0003136_yellow_coat_color | 1.64937963 |
20 | MP0001486_abnormal_startle_reflex | 1.60675904 |
21 | MP0002210_abnormal_sex_determination | 1.50777328 |
22 | MP0002249_abnormal_larynx_morphology | 1.47272591 |
23 | MP0003718_maternal_effect | 1.46201468 |
24 | MP0001485_abnormal_pinna_reflex | 1.44388829 |
25 | MP0004742_abnormal_vestibular_system | 1.35120420 |
26 | MP0005671_abnormal_response_to | 1.31658601 |
27 | MP0003011_delayed_dark_adaptation | 1.25953243 |
28 | MP0001963_abnormal_hearing_physiology | 1.22223578 |
29 | MP0000026_abnormal_inner_ear | 1.21531347 |
30 | MP0001968_abnormal_touch/_nociception | 1.19649428 |
31 | MP0006276_abnormal_autonomic_nervous | 1.16912323 |
32 | MP0003879_abnormal_hair_cell | 1.16120775 |
33 | MP0005551_abnormal_eye_electrophysiolog | 1.13589993 |
34 | MP0000733_abnormal_muscle_development | 1.06137209 |
35 | MP0001145_abnormal_male_reproductive | 1.04530331 |
36 | MP0003137_abnormal_impulse_conducting | 1.03723167 |
37 | MP0000653_abnormal_sex_gland | 1.02964343 |
38 | MP0002282_abnormal_trachea_morphology | 1.02257694 |
39 | MP0001879_abnormal_lymphatic_vessel | 0.99205318 |
40 | MP0008875_abnormal_xenobiotic_pharmacok | 0.96312749 |
41 | MP0010386_abnormal_urinary_bladder | 0.94042107 |
42 | MP0005171_absent_coat_pigmentation | 0.93779005 |
43 | MP0005395_other_phenotype | 0.91594403 |
44 | MP0009115_abnormal_fat_cell | 0.91172917 |
45 | MP0002138_abnormal_hepatobiliary_system | 0.89905359 |
46 | MP0002234_abnormal_pharynx_morphology | 0.89349835 |
47 | MP0005083_abnormal_biliary_tract | 0.88283676 |
48 | MP0002733_abnormal_thermal_nociception | 0.87915271 |
49 | MP0002229_neurodegeneration | 0.87476328 |
50 | MP0000534_abnormal_ureter_morphology | 0.85746488 |
51 | MP0005360_urolithiasis | 0.85222510 |
52 | MP0003866_abnormal_defecation | 0.84142301 |
53 | MP0002933_joint_inflammation | 0.83906481 |
54 | MP0001881_abnormal_mammary_gland | 0.83896359 |
55 | MP0005645_abnormal_hypothalamus_physiol | 0.83260498 |
56 | MP0002102_abnormal_ear_morphology | 0.81644966 |
57 | MP0005310_abnormal_salivary_gland | 0.80729747 |
58 | MP0000230_abnormal_systemic_arterial | 0.80202265 |
59 | MP0001765_abnormal_ion_homeostasis | 0.79757893 |
60 | MP0000049_abnormal_middle_ear | 0.79204106 |
61 | MP0009278_abnormal_bone_marrow | 0.76845341 |
62 | MP0003950_abnormal_plasma_membrane | 0.74640039 |
63 | MP0005379_endocrine/exocrine_gland_phen | 0.72536576 |
64 | MP0001529_abnormal_vocalization | 0.72285541 |
65 | MP0004133_heterotaxia | 0.71532456 |
66 | MP0005266_abnormal_metabolism | 0.70081439 |
67 | MP0001970_abnormal_pain_threshold | 0.65875945 |
68 | MP0002067_abnormal_sensory_capabilities | 0.64357776 |
69 | MP0004233_abnormal_muscle_weight | 0.64011027 |
70 | MP0002136_abnormal_kidney_physiology | 0.63586763 |
71 | MP0001873_stomach_inflammation | 0.62714271 |
72 | MP0009384_cardiac_valve_regurgitation | 0.62431997 |
73 | MP0005666_abnormal_adipose_tissue | 0.61395392 |
74 | MP0002932_abnormal_joint_morphology | 0.61056179 |
75 | MP0002108_abnormal_muscle_morphology | 0.61010779 |
76 | MP0004085_abnormal_heartbeat | 0.60486063 |
77 | MP0002168_other_aberrant_phenotype | 0.60114756 |
78 | MP0002127_abnormal_cardiovascular_syste | 0.59946372 |
79 | MP0005451_abnormal_body_composition | 0.59537641 |
80 | MP0009745_abnormal_behavioral_response | 0.58081927 |
81 | MP0000955_abnormal_spinal_cord | 0.57419105 |
82 | MP0008770_decreased_survivor_rate | 0.56207593 |
83 | MP0001800_abnormal_humoral_immune | 0.55985304 |
84 | MP0005623_abnormal_meninges_morphology | 0.55532269 |
85 | MP0005332_abnormal_amino_acid | 0.55476172 |
86 | MP0002557_abnormal_social/conspecific_i | 0.54721348 |
87 | MP0000569_abnormal_digit_pigmentation | 0.53134562 |
88 | MP0003699_abnormal_female_reproductive | 0.51668306 |
89 | MP0002909_abnormal_adrenal_gland | 0.50533390 |
90 | MP0003045_fibrosis | 0.49932588 |
91 | MP0003283_abnormal_digestive_organ | 0.49873981 |
92 | MP0010368_abnormal_lymphatic_system | 0.49577884 |
93 | MP0005248_abnormal_Harderian_gland | 0.49181570 |
94 | MP0003763_abnormal_thymus_physiology | 0.49109639 |
95 | MP0005085_abnormal_gallbladder_physiolo | 0.48176787 |
96 | MP0002160_abnormal_reproductive_system | 0.48035941 |
97 | MP0002723_abnormal_immune_serum | 0.47139084 |
98 | MP0002736_abnormal_nociception_after | 0.47043457 |
99 | MP0002277_abnormal_respiratory_mucosa | 0.44507548 |
100 | MP0005535_abnormal_body_temperature | 0.43810986 |
Rank | Gene Set | Z-score |
---|---|---|
1 | Severe visual impairment (HP:0001141) | 8.44517362 |
2 | Absent/shortened dynein arms (HP:0200106) | 6.90013448 |
3 | Dynein arm defect of respiratory motile cilia (HP:0012255) | 6.90013448 |
4 | Attenuation of retinal blood vessels (HP:0007843) | 4.23746092 |
5 | Increased IgE level (HP:0003212) | 4.19534159 |
6 | Asymmetric septal hypertrophy (HP:0001670) | 4.04178278 |
7 | Abnormal respiratory motile cilium morphology (HP:0005938) | 3.84644175 |
8 | Abnormal respiratory epithelium morphology (HP:0012253) | 3.84644175 |
9 | Sensory axonal neuropathy (HP:0003390) | 3.74653198 |
10 | Abnormal respiratory motile cilium physiology (HP:0012261) | 3.63764210 |
11 | Abnormal ciliary motility (HP:0012262) | 3.59433436 |
12 | Tubular atrophy (HP:0000092) | 3.56471789 |
13 | Chronic hepatic failure (HP:0100626) | 3.46080565 |
14 | Hypoplastic ischia (HP:0003175) | 3.43884268 |
15 | Enlarged epiphyses (HP:0010580) | 3.42516553 |
16 | Bony spicule pigmentary retinopathy (HP:0007737) | 3.41900753 |
17 | Hyperkalemia (HP:0002153) | 3.38153793 |
18 | Abnormal rod and cone electroretinograms (HP:0008323) | 3.18080696 |
19 | Nephronophthisis (HP:0000090) | 3.08950832 |
20 | Stage 5 chronic kidney disease (HP:0003774) | 3.05371347 |
21 | Abnormality of the ischium (HP:0003174) | 3.03303035 |
22 | Polydipsia (HP:0001959) | 2.97765412 |
23 | Abnormal drinking behavior (HP:0030082) | 2.97765412 |
24 | Hypoplasia of the thymus (HP:0000778) | 2.96285667 |
25 | Parkinsonism with favorable response to dopaminergic medication (HP:0002548) | 2.91640556 |
26 | Tubulointerstitial nephritis (HP:0001970) | 2.88854891 |
27 | Respiratory insufficiency due to defective ciliary clearance (HP:0200073) | 2.88633474 |
28 | Tubulointerstitial abnormality (HP:0001969) | 2.81078471 |
29 | True hermaphroditism (HP:0010459) | 2.78140987 |
30 | Aplasia/Hypoplasia of the pubic bone (HP:0009104) | 2.77544604 |
31 | Pancreatic fibrosis (HP:0100732) | 2.74666874 |
32 | Pancreatic cysts (HP:0001737) | 2.70602608 |
33 | Abnormality of the nasal septum (HP:0000419) | 2.69951227 |
34 | Facial shape deformation (HP:0011334) | 2.64990834 |
35 | Potter facies (HP:0002009) | 2.64990834 |
36 | Slow saccadic eye movements (HP:0000514) | 2.64096069 |
37 | Abnormal urine output (HP:0012590) | 2.63148447 |
38 | Abnormality of macular pigmentation (HP:0008002) | 2.61605407 |
39 | Abnormality of the renal medulla (HP:0100957) | 2.60750222 |
40 | Male infertility (HP:0003251) | 2.58653144 |
41 | Tubulointerstitial fibrosis (HP:0005576) | 2.58267570 |
42 | Bell-shaped thorax (HP:0001591) | 2.57389360 |
43 | Renovascular hypertension (HP:0100817) | 2.56828421 |
44 | Hypoalbuminemia (HP:0003073) | 2.51414723 |
45 | Abnormal albumin level (HP:0012116) | 2.51414723 |
46 | Cerebral hypomyelination (HP:0006808) | 2.51185743 |
47 | Recurrent corneal erosions (HP:0000495) | 2.50267223 |
48 | Aplasia/Hypoplasia of the earlobes (HP:0009906) | 2.48951174 |
49 | Infertility (HP:0000789) | 2.48374778 |
50 | Polyuria (HP:0000103) | 2.44419057 |
51 | Progressive cerebellar ataxia (HP:0002073) | 2.38703968 |
52 | Focal segmental glomerulosclerosis (HP:0000097) | 2.33199551 |
53 | Abnormality of the epiphysis of the femoral head (HP:0010574) | 2.33177704 |
54 | Spastic paraparesis (HP:0002313) | 2.31860659 |
55 | Resting tremor (HP:0002322) | 2.30882812 |
56 | Nasal polyposis (HP:0100582) | 2.28877024 |
57 | Abnormality of the femoral head (HP:0003368) | 2.27947559 |
58 | Menstrual irregularities (HP:0000858) | 2.22854259 |
59 | Abnormal spermatogenesis (HP:0008669) | 2.21587515 |
60 | Azoospermia (HP:0000027) | 2.19363729 |
61 | Abnormality of renal excretion (HP:0011036) | 2.18680529 |
62 | Flat capital femoral epiphysis (HP:0003370) | 2.17706616 |
63 | Amelogenesis imperfecta (HP:0000705) | 2.17270602 |
64 | Retinal atrophy (HP:0001105) | 2.16158062 |
65 | Genetic anticipation (HP:0003743) | 2.13194903 |
66 | Abnormality of femoral epiphyses (HP:0006499) | 2.13084970 |
67 | Abnormality involving the epiphyses of the lower limbs (HP:0006500) | 2.13084970 |
68 | Congenital hepatic fibrosis (HP:0002612) | 2.12559222 |
69 | Occipital encephalocele (HP:0002085) | 2.12258481 |
70 | Decreased central vision (HP:0007663) | 2.11926119 |
71 | Cystic liver disease (HP:0006706) | 2.10320317 |
72 | Abnormality of the renal cortex (HP:0011035) | 2.02542643 |
73 | Elevated erythrocyte sedimentation rate (HP:0003565) | 2.01576473 |
74 | Cerebellar dysplasia (HP:0007033) | 2.01334234 |
75 | Prostate neoplasm (HP:0100787) | 2.00158457 |
76 | Generalized aminoaciduria (HP:0002909) | 1.96812792 |
77 | Pigmentary retinal degeneration (HP:0001146) | 1.96477230 |
78 | Abnormality of the costochondral junction (HP:0000919) | 1.96058576 |
79 | Abnormality of potassium homeostasis (HP:0011042) | 1.95684248 |
80 | Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003) | 1.95072145 |
81 | Absent epiphyses (HP:0010577) | 1.95072145 |
82 | Congenital sensorineural hearing impairment (HP:0008527) | 1.93433400 |
83 | Renal dysplasia (HP:0000110) | 1.92071445 |
84 | Glomerulosclerosis (HP:0000096) | 1.89201466 |
85 | Impulsivity (HP:0100710) | 1.87800639 |
86 | Sclerocornea (HP:0000647) | 1.87767197 |
87 | Amblyopia (HP:0000646) | 1.87568001 |
88 | Abnormality of the nasal mucosa (HP:0000433) | 1.84992740 |
89 | Cone-rod dystrophy (HP:0000548) | 1.81266967 |
90 | Osteomalacia (HP:0002749) | 1.79765530 |
91 | Bulbous nose (HP:0000414) | 1.77886637 |
92 | Mixed hearing impairment (HP:0000410) | 1.77824808 |
93 | Optic nerve hypoplasia (HP:0000609) | 1.77653217 |
94 | Progressive sensorineural hearing impairment (HP:0000408) | 1.74280845 |
95 | Portal hypertension (HP:0001409) | 1.73116941 |
96 | Flattened epiphyses (HP:0003071) | 1.71257014 |
97 | Rib fusion (HP:0000902) | 1.70910253 |
98 | Atelectasis (HP:0100750) | 1.70273687 |
99 | Bowel incontinence (HP:0002607) | 1.68276402 |
100 | Macular degeneration (HP:0000608) | 1.67691822 |
Rank | Gene Set | Z-score |
---|---|---|
1 | PLK4 | 6.22359101 |
2 | TESK1 | 4.72685044 |
3 | MAP4K2 | 4.28587979 |
4 | DDR2 | 3.71586831 |
5 | MAPK15 | 3.63598636 |
6 | TESK2 | 3.54965915 |
7 | PNCK | 3.51936376 |
8 | INSRR | 2.51279933 |
9 | BRD4 | 2.40922498 |
10 | TLK1 | 2.32232056 |
11 | PRKD3 | 2.28975473 |
12 | TXK | 2.16287132 |
13 | CDK12 | 2.14227668 |
14 | SIK2 | 1.93565098 |
15 | STK38 | 1.80663360 |
16 | STK38L | 1.79380486 |
17 | MST1R | 1.77213215 |
18 | CAMK1G | 1.62848083 |
19 | ZAK | 1.34903720 |
20 | LATS1 | 1.33433047 |
21 | PLK2 | 1.29901189 |
22 | TAOK3 | 1.24698808 |
23 | ICK | 1.19503343 |
24 | NEK6 | 1.17472507 |
25 | BRSK2 | 1.14745902 |
26 | PDPK1 | 1.12829151 |
27 | PDK1 | 1.08765442 |
28 | KDR | 1.07387452 |
29 | CAMK1D | 1.06937650 |
30 | MAP4K1 | 1.04010732 |
31 | BMX | 1.02530659 |
32 | LATS2 | 0.93024173 |
33 | ADRBK2 | 0.89356409 |
34 | PIK3CG | 0.88596416 |
35 | CDK7 | 0.86693140 |
36 | VRK1 | 0.86591367 |
37 | PIM2 | 0.85851698 |
38 | PTK2B | 0.84587790 |
39 | MAP2K2 | 0.83857134 |
40 | ACVR1B | 0.82137669 |
41 | KSR2 | 0.82127891 |
42 | MAPK11 | 0.79635665 |
43 | IRAK4 | 0.77614148 |
44 | PINK1 | 0.74087669 |
45 | WNK1 | 0.73987470 |
46 | DYRK1B | 0.73056016 |
47 | BMPR1B | 0.69926408 |
48 | PRKAA2 | 0.67424500 |
49 | MAPKAPK5 | 0.66792203 |
50 | MTOR | 0.66019240 |
51 | RPS6KA1 | 0.62537368 |
52 | WNK4 | 0.61473818 |
53 | NME1 | 0.61316463 |
54 | MARK3 | 0.60001813 |
55 | TEC | 0.59061921 |
56 | IKBKB | 0.56764683 |
57 | MAP3K6 | 0.56060864 |
58 | ITK | 0.55456191 |
59 | GRK6 | 0.54611883 |
60 | CAMKK2 | 0.52784758 |
61 | ZAP70 | 0.52189602 |
62 | BRSK1 | 0.52167856 |
63 | BLK | 0.52045787 |
64 | PRKAA1 | 0.50111974 |
65 | MAP3K11 | 0.49241362 |
66 | MAPKAPK3 | 0.47802132 |
67 | ROCK1 | 0.47153569 |
68 | MET | 0.46992875 |
69 | RPS6KA2 | 0.46646145 |
70 | BCKDK | 0.46245362 |
71 | TRPM7 | 0.46142792 |
72 | RPS6KA6 | 0.44670596 |
73 | CAMK1 | 0.44574762 |
74 | RPS6KA5 | 0.42798738 |
75 | PKN1 | 0.42723005 |
76 | MAPK1 | 0.41050250 |
77 | MAPK8 | 0.40851049 |
78 | CDK2 | 0.39109821 |
79 | CDK3 | 0.36920780 |
80 | SYK | 0.36417937 |
81 | TYRO3 | 0.36208773 |
82 | IKBKE | 0.35588725 |
83 | CHUK | 0.35514537 |
84 | GSK3B | 0.35296833 |
85 | RPS6KL1 | 0.31862504 |
86 | RPS6KC1 | 0.31862504 |
87 | MAPKAPK2 | 0.31792745 |
88 | NEK9 | 0.29114923 |
89 | CDK4 | 0.28852152 |
90 | NEK2 | 0.28522808 |
91 | PRKG1 | 0.27687925 |
92 | MAP3K7 | 0.27613435 |
93 | TIE1 | 0.26741972 |
94 | NLK | 0.26516970 |
95 | AURKA | 0.26322228 |
96 | BTK | 0.23831111 |
97 | CDK1 | 0.23360812 |
98 | GRK7 | 0.23006439 |
99 | MAP3K9 | 0.22935033 |
100 | RAF1 | 0.22029875 |
Rank | Gene Set | Z-score |
---|---|---|
1 | Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072 | 6.67332542 |
2 | Fatty acid biosynthesis_Homo sapiens_hsa00061 | 4.63952501 |
3 | Olfactory transduction_Homo sapiens_hsa04740 | 2.99931467 |
4 | Butanoate metabolism_Homo sapiens_hsa00650 | 2.71051785 |
5 | Systemic lupus erythematosus_Homo sapiens_hsa05322 | 2.34125089 |
6 | Taste transduction_Homo sapiens_hsa04742 | 2.02483242 |
7 | Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080 | 1.99213193 |
8 | Antigen processing and presentation_Homo sapiens_hsa04612 | 1.96811298 |
9 | Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760 | 1.87220058 |
10 | Sulfur relay system_Homo sapiens_hsa04122 | 1.66825080 |
11 | Primary immunodeficiency_Homo sapiens_hsa05340 | 1.62887841 |
12 | Graft-versus-host disease_Homo sapiens_hsa05332 | 1.60168017 |
13 | Dorso-ventral axis formation_Homo sapiens_hsa04320 | 1.56136123 |
14 | Alcoholism_Homo sapiens_hsa05034 | 1.51764474 |
15 | Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512 | 1.35998414 |
16 | Autoimmune thyroid disease_Homo sapiens_hsa05320 | 1.33632055 |
17 | Allograft rejection_Homo sapiens_hsa05330 | 1.32390127 |
18 | Adipocytokine signaling pathway_Homo sapiens_hsa04920 | 1.32125410 |
19 | Longevity regulating pathway - multiple species_Homo sapiens_hsa04213 | 1.29759680 |
20 | Notch signaling pathway_Homo sapiens_hsa04330 | 1.28716840 |
21 | Phototransduction_Homo sapiens_hsa04744 | 1.27058469 |
22 | Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601 | 1.24598596 |
23 | Viral carcinogenesis_Homo sapiens_hsa05203 | 1.20207545 |
24 | Glycerophospholipid metabolism_Homo sapiens_hsa00564 | 1.17239532 |
25 | Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603 | 1.15214513 |
26 | Progesterone-mediated oocyte maturation_Homo sapiens_hsa04914 | 1.12357506 |
27 | Nitrogen metabolism_Homo sapiens_hsa00910 | 1.12175436 |
28 | Phenylalanine metabolism_Homo sapiens_hsa00360 | 1.06752990 |
29 | ABC transporters_Homo sapiens_hsa02010 | 1.04652536 |
30 | Salivary secretion_Homo sapiens_hsa04970 | 1.00461840 |
31 | Maturity onset diabetes of the young_Homo sapiens_hsa04950 | 0.99741756 |
32 | Non-homologous end-joining_Homo sapiens_hsa03450 | 0.99628480 |
33 | Fanconi anemia pathway_Homo sapiens_hsa03460 | 0.96369711 |
34 | Basal transcription factors_Homo sapiens_hsa03022 | 0.96322394 |
35 | Selenocompound metabolism_Homo sapiens_hsa00450 | 0.95611070 |
36 | Influenza A_Homo sapiens_hsa05164 | 0.94352297 |
37 | Calcium signaling pathway_Homo sapiens_hsa04020 | 0.92221154 |
38 | Type I diabetes mellitus_Homo sapiens_hsa04940 | 0.91345599 |
39 | Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623 | 0.91202810 |
40 | Arginine and proline metabolism_Homo sapiens_hsa00330 | 0.91144498 |
41 | T cell receptor signaling pathway_Homo sapiens_hsa04660 | 0.86304880 |
42 | Protein digestion and absorption_Homo sapiens_hsa04974 | 0.85977112 |
43 | Type II diabetes mellitus_Homo sapiens_hsa04930 | 0.84118836 |
44 | Measles_Homo sapiens_hsa05162 | 0.83116826 |
45 | Linoleic acid metabolism_Homo sapiens_hsa00591 | 0.82315946 |
46 | Basal cell carcinoma_Homo sapiens_hsa05217 | 0.79227253 |
47 | Acute myeloid leukemia_Homo sapiens_hsa05221 | 0.77432915 |
48 | Propanoate metabolism_Homo sapiens_hsa00640 | 0.76443677 |
49 | MAPK signaling pathway_Homo sapiens_hsa04010 | 0.76176281 |
50 | Cholinergic synapse_Homo sapiens_hsa04725 | 0.74443987 |
51 | cAMP signaling pathway_Homo sapiens_hsa04024 | 0.74007453 |
52 | Fatty acid degradation_Homo sapiens_hsa00071 | 0.73548871 |
53 | Transcriptional misregulation in cancer_Homo sapiens_hsa05202 | 0.71842753 |
54 | Chemical carcinogenesis_Homo sapiens_hsa05204 | 0.71456258 |
55 | Viral myocarditis_Homo sapiens_hsa05416 | 0.69362295 |
56 | Glycosaminoglycan degradation_Homo sapiens_hsa00531 | 0.68051929 |
57 | RNA transport_Homo sapiens_hsa03013 | 0.63796247 |
58 | Tyrosine metabolism_Homo sapiens_hsa00350 | 0.63392238 |
59 | Intestinal immune network for IgA production_Homo sapiens_hsa04672 | 0.62442791 |
60 | Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060 | 0.60373003 |
61 | Hedgehog signaling pathway_Homo sapiens_hsa04340 | 0.60262636 |
62 | Circadian rhythm_Homo sapiens_hsa04710 | 0.58878909 |
63 | Fc gamma R-mediated phagocytosis_Homo sapiens_hsa04666 | 0.58547121 |
64 | NF-kappa B signaling pathway_Homo sapiens_hsa04064 | 0.57375367 |
65 | Lysine degradation_Homo sapiens_hsa00310 | 0.57362908 |
66 | Morphine addiction_Homo sapiens_hsa05032 | 0.56831012 |
67 | Endocytosis_Homo sapiens_hsa04144 | 0.54967780 |
68 | alpha-Linolenic acid metabolism_Homo sapiens_hsa00592 | 0.53786222 |
69 | Glycerolipid metabolism_Homo sapiens_hsa00561 | 0.53783514 |
70 | Jak-STAT signaling pathway_Homo sapiens_hsa04630 | 0.53761478 |
71 | Retinol metabolism_Homo sapiens_hsa00830 | 0.53311828 |
72 | Protein processing in endoplasmic reticulum_Homo sapiens_hsa04141 | 0.53096402 |
73 | NOD-like receptor signaling pathway_Homo sapiens_hsa04621 | 0.53062452 |
74 | Purine metabolism_Homo sapiens_hsa00230 | 0.51979815 |
75 | Cardiac muscle contraction_Homo sapiens_hsa04260 | 0.50526156 |
76 | Legionellosis_Homo sapiens_hsa05134 | 0.48971934 |
77 | Tryptophan metabolism_Homo sapiens_hsa00380 | 0.48377749 |
78 | VEGF signaling pathway_Homo sapiens_hsa04370 | 0.48054527 |
79 | Bile secretion_Homo sapiens_hsa04976 | 0.45855006 |
80 | Herpes simplex infection_Homo sapiens_hsa05168 | 0.45582398 |
81 | Carbohydrate digestion and absorption_Homo sapiens_hsa04973 | 0.45413703 |
82 | Histidine metabolism_Homo sapiens_hsa00340 | 0.45186434 |
83 | PPAR signaling pathway_Homo sapiens_hsa03320 | 0.43947622 |
84 | Thyroid hormone signaling pathway_Homo sapiens_hsa04919 | 0.42733465 |
85 | Taurine and hypotaurine metabolism_Homo sapiens_hsa00430 | 0.36963212 |
86 | Oxytocin signaling pathway_Homo sapiens_hsa04921 | 0.35830044 |
87 | Steroid hormone biosynthesis_Homo sapiens_hsa00140 | 0.35684934 |
88 | Glutamatergic synapse_Homo sapiens_hsa04724 | 0.35176222 |
89 | Glycolysis / Gluconeogenesis_Homo sapiens_hsa00010 | 0.34831731 |
90 | Aldosterone synthesis and secretion_Homo sapiens_hsa04925 | 0.34601489 |
91 | Gastric acid secretion_Homo sapiens_hsa04971 | 0.34075391 |
92 | Estrogen signaling pathway_Homo sapiens_hsa04915 | 0.33863079 |
93 | Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280 | 0.33206860 |
94 | Serotonergic synapse_Homo sapiens_hsa04726 | 0.33060732 |
95 | Other types of O-glycan biosynthesis_Homo sapiens_hsa00514 | 0.32291362 |
96 | Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130 | 0.31655566 |
97 | Fatty acid metabolism_Homo sapiens_hsa01212 | 0.31212893 |
98 | FoxO signaling pathway_Homo sapiens_hsa04068 | 0.30973032 |
99 | Vascular smooth muscle contraction_Homo sapiens_hsa04270 | 0.30257587 |
100 | RNA polymerase_Homo sapiens_hsa03020 | 0.28997241 |