SLC35G6

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1sperm motility (GO:0030317)9.98171189
2acrosome reaction (GO:0007340)9.71078050
3fusion of sperm to egg plasma membrane (GO:0007342)8.93045510
4microtubule depolymerization (GO:0007019)8.08016088
5response to pheromone (GO:0019236)7.85825495
6chromosome condensation (GO:0030261)7.44779342
7spermatid development (GO:0007286)7.38660058
8single strand break repair (GO:0000012)7.27167380
9sperm capacitation (GO:0048240)7.22402346
10DNA packaging (GO:0006323)7.22239747
11negative regulation of inclusion body assembly (GO:0090084)6.89454573
12plasma membrane fusion (GO:0045026)6.72226619
13spermatid nucleus differentiation (GO:0007289)6.33758056
14multicellular organism reproduction (GO:0032504)6.29497308
15cellular ketone body metabolic process (GO:0046950)6.22334208
16protein polyglutamylation (GO:0018095)6.03732861
17microtubule polymerization or depolymerization (GO:0031109)5.94868319
18reproduction (GO:0000003)5.90321373
19sperm-egg recognition (GO:0035036)5.89325257
20sexual reproduction (GO:0019953)5.68970834
21phosphatidylethanolamine biosynthetic process (GO:0006646)5.45897297
22ketone body metabolic process (GO:1902224)5.45475942
23rRNA methylation (GO:0031167)5.38952331
24spermatogenesis (GO:0007283)5.27980028
25male gamete generation (GO:0048232)5.26970375
26calcium ion-dependent exocytosis (GO:0017156)5.11861132
27cell-cell recognition (GO:0009988)5.09931671
28antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G4.97740419
29protein targeting to Golgi (GO:0000042)4.92696948
30phosphatidylethanolamine metabolic process (GO:0046337)4.92326767
31binding of sperm to zona pellucida (GO:0007339)4.92269082
32glomerular visceral epithelial cell development (GO:0072015)4.91967749
33gamete generation (GO:0007276)4.82274236
34axonemal dynein complex assembly (GO:0070286)4.81949038
35establishment of protein localization to Golgi (GO:0072600)4.80272199
36retrograde transport, vesicle recycling within Golgi (GO:0000301)4.76049675
37positive regulation of Rab GTPase activity (GO:0032851)4.75835375
38regulation of Rab GTPase activity (GO:0032313)4.75835375
39cilium or flagellum-dependent cell motility (GO:0001539)4.64285979
40coenzyme catabolic process (GO:0009109)4.60698713
41rRNA modification (GO:0000154)4.60496960
42glomerular epithelial cell development (GO:0072310)4.50699041
43growth hormone secretion (GO:0030252)4.49705281
44motile cilium assembly (GO:0044458)4.42888814
45centriole replication (GO:0007099)4.41862211
46RNA destabilization (GO:0050779)4.40641011
47microtubule severing (GO:0051013)4.27425695
48regulation of gamma-delta T cell differentiation (GO:0045586)4.21023924
49regulation of inclusion body assembly (GO:0090083)4.17196016
50chromatin silencing (GO:0006342)4.16151316
51single fertilization (GO:0007338)4.15757481
52germ cell development (GO:0007281)4.04023634
53multicellular organismal reproductive process (GO:0048609)3.97728771
54seminiferous tubule development (GO:0072520)3.91520372
55protein localization to Golgi apparatus (GO:0034067)3.90608667
56organic cation transport (GO:0015695)3.87282311
57centriole assembly (GO:0098534)3.83354998
58positive regulation of growth hormone secretion (GO:0060124)3.81875612
59cellular process involved in reproduction in multicellular organism (GO:0022412)3.62080692
60regulation of transcription involved in cell fate commitment (GO:0060850)3.52965827
61regulation of cilium movement (GO:0003352)3.52551108
62regulation of centriole replication (GO:0046599)3.48931176
63nucleus organization (GO:0006997)3.48258867
64fertilization (GO:0009566)3.47484246
65determination of adult lifespan (GO:0008340)3.45076930
66negative regulation of Rho protein signal transduction (GO:0035024)3.44324699
67regulation of somitogenesis (GO:0014807)3.43911266
68musculoskeletal movement (GO:0050881)3.43829646
69multicellular organismal movement (GO:0050879)3.43829646
70urinary tract smooth muscle contraction (GO:0014848)3.43657516
71regulation of gamma-delta T cell activation (GO:0046643)3.41659186
72mesonephros development (GO:0001823)3.29688558
73urogenital system development (GO:0001655)3.29670715
74endothelial cell chemotaxis (GO:0035767)3.24468080
75protein depolymerization (GO:0051261)3.23357950
76behavioral response to nicotine (GO:0035095)3.10448494
77regulation of growth hormone secretion (GO:0060123)3.05987402
78negative regulation of gene expression, epigenetic (GO:0045814)3.01203223
79cell wall macromolecule catabolic process (GO:0016998)2.97575672
80positive regulation of T cell mediated cytotoxicity (GO:0001916)2.93889370
81male meiosis I (GO:0007141)2.86249124
82cartilage development involved in endochondral bone morphogenesis (GO:0060351)2.85732254
83multicellular organismal development (GO:0007275)2.84082713
84epithelial cilium movement (GO:0003351)2.83021880
85peptidyl-threonine dephosphorylation (GO:0035970)2.83015268
86negative regulation of mesenchymal cell apoptotic process (GO:2001054)2.82247495
87cell wall macromolecule metabolic process (GO:0044036)2.81827653
88homeostasis of number of cells within a tissue (GO:0048873)2.81711531
89regulation of insulin-like growth factor receptor signaling pathway (GO:0043567)2.80901975
90positive regulation of insulin-like growth factor receptor signaling pathway (GO:0043568)2.79982549
91neuromuscular synaptic transmission (GO:0007274)2.78768848
92positive regulation of endothelial cell differentiation (GO:0045603)2.78525642
93estrogen biosynthetic process (GO:0006703)2.76977198
94protein K48-linked deubiquitination (GO:0071108)2.76839419
95membrane protein intracellular domain proteolysis (GO:0031293)2.72551028
96left/right axis specification (GO:0070986)2.70637978
97regulation of female gonad development (GO:2000194)2.68418420
98mitochondrial fission (GO:0000266)2.68143710
99mitotic G1/S transition checkpoint (GO:0044819)2.66759851
100tRNA methylation (GO:0030488)2.64843565

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human4.72754378
2SOX9_22984422_ChIP-ChIP_TESTIS_Rat4.05798846
3STAT6_21828071_ChIP-Seq_BEAS2B_Human3.93098104
4TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat3.65656874
5FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.61917530
6DROSHA_22980978_ChIP-Seq_HELA_Human2.45239160
7EZH2_22144423_ChIP-Seq_EOC_Human2.35666815
8ERA_21632823_ChIP-Seq_H3396_Human2.14796952
9RBPJ_21746931_ChIP-Seq_IB4-LCL_Human2.09605323
10RAC3_21632823_ChIP-Seq_H3396_Human2.04354524
11GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.01012868
12VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human1.97627951
13EBNA2_21746931_ChIP-Seq_IB4-LCL_Human1.96988322
14YY1_22570637_ChIP-Seq_MALME-3M_Human1.96671498
15WDR5_24793694_ChIP-Seq_LNCAP_Human1.96159190
16BCL6_27268052_Chip-Seq_Bcells_Human1.93786690
17CTCF_27219007_Chip-Seq_Bcells_Human1.93698469
18TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.90846393
19POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.90846393
20E2F1_20622854_ChIP-Seq_HELA_Human1.87511897
21PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.84192433
22CTBP2_25329375_ChIP-Seq_LNCAP_Human1.82957635
23P68_20966046_ChIP-Seq_HELA_Human1.82564387
24EBNA1_20929547_Chip-Seq_RAJI-cells_Human1.79489904
25BCOR_27268052_Chip-Seq_Bcells_Human1.78719783
26SMC4_20622854_ChIP-Seq_HELA_Human1.69743435
27ELF1_20517297_ChIP-Seq_JURKAT_Human1.66418177
28ER_23166858_ChIP-Seq_MCF-7_Human1.65455453
29EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.62675295
30TDRD3_21172665_ChIP-Seq_MCF-7_Human1.60665224
31PHF8_20622854_ChIP-Seq_HELA_Human1.60555007
32CTBP1_25329375_ChIP-Seq_LNCAP_Human1.59494486
33NANOG_20526341_ChIP-Seq_ESCs_Human1.58423590
34P63_20808887_ChIP-Seq_KERATINOCYTES_Human1.56129386
35OCT4_20526341_ChIP-Seq_ESCs_Human1.55212567
36LXR_22292898_ChIP-Seq_THP-1_Human1.54712747
37GATA3_21878914_ChIP-Seq_MCF-7_Human1.54178312
38CBP_20019798_ChIP-Seq_JUKART_Human1.53417275
39IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.53417275
40TP63_22573176_ChIP-Seq_HFKS_Human1.52164246
41TAF2_19829295_ChIP-Seq_ESCs_Human1.52164049
42RUNX_20019798_ChIP-Seq_JUKART_Human1.47760818
43CTCF_20526341_ChIP-Seq_ESCs_Human1.47636615
44SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.43027947
45SUZ12_27294783_Chip-Seq_ESCs_Mouse1.42844578
46P300_27268052_Chip-Seq_Bcells_Human1.41001610
47MYC_19829295_ChIP-Seq_ESCs_Human1.37568985
48ZNF274_21170338_ChIP-Seq_K562_Hela1.33226541
49SA1_27219007_Chip-Seq_Bcells_Human1.32049315
50SMAD2/3_21741376_ChIP-Seq_ESCs_Human1.29254304
51EZH2_27294783_Chip-Seq_ESCs_Mouse1.28128776
52ARNT_22903824_ChIP-Seq_MCF-7_Human1.27836914
53CEBPB_22108803_ChIP-Seq_LS180_Human1.27519252
54CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.23691941
55JARID2_20075857_ChIP-Seq_MESCs_Mouse1.23516654
56AUTS2_25519132_ChIP-Seq_293T-REX_Human1.23414162
57GATA1_19941826_ChIP-Seq_K562_Human1.21860549
58SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.20146069
59P53_21459846_ChIP-Seq_SAOS-2_Human1.20001518
60SMAD4_21741376_ChIP-Seq_EPCs_Human1.19954544
61PBX1_22567123_ChIP-ChIP_OVCAR3_Human1.19702616
62ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.18916625
63PPARD_23208498_ChIP-Seq_MDA-MB-231_Human1.18758805
64JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.17526325
65ERG_20517297_ChIP-Seq_VCAP_Human1.16925401
66DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.15938377
67UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.15574034
68TP53_18474530_ChIP-ChIP_U2OS_Human1.12986199
69CSB_26484114_Chip-Seq_FIBROBLAST_Human1.11476297
70EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.11432147
71SOX2_22085726_ChIP-Seq_NPCs_Mouse1.09872887
72KLF4_19829295_ChIP-Seq_ESCs_Human1.09282935
73CBX2_22325352_ChIP-Seq_293T-Rex_Human1.09106434
74HOXB7_26014856_ChIP-Seq_BT474_Human1.08870065
75E2F1_17053090_ChIP-ChIP_MCF-7_Human1.08681361
76RBPJ_21746931_ChIP-Seq_IB4_Human1.07472972
77SPI1_20517297_ChIP-Seq_HL60_Human1.06554369
78HNFA_21074721_ChIP-Seq_CACO-2_Human1.06513250
79ETV2_25802403_ChIP-Seq_MESCs_Mouse1.06040446
80ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.05587752
81TP63_19390658_ChIP-ChIP_HaCaT_Human1.05144364
82SMAD3_21741376_ChIP-Seq_ESCs_Human1.03567253
83ETV1_20927104_ChIP-Seq_GIST48_Human1.03300910
84OCT4_19829295_ChIP-Seq_ESCs_Human1.02732777
85EZH2_27304074_Chip-Seq_ESCs_Mouse1.01667592
86NFYB_21822215_ChIP-Seq_K562_Human1.01345229
87PHF8_20622853_ChIP-Seq_HELA_Human1.00403848
88CTCF_21964334_Chip-Seq_Bcells_Human0.99462488
89SMAD3_21741376_ChIP-Seq_EPCs_Human0.99435317
90BP1_19119308_ChIP-ChIP_Hs578T_Human0.99115330
91CDX2_21074721_ChIP-Seq_CACO-2_Mouse0.98503839
92IRF8_22096565_ChIP-ChIP_GC-B_Human0.98472915
93FUS_26573619_Chip-Seq_HEK293_Human0.98012623
94GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.97587323
95NCOR_22424771_ChIP-Seq_293T_Human0.96663308
96RUNX1_27514584_Chip-Seq_MCF-7_Human0.96255474
97AR_25329375_ChIP-Seq_VCAP_Human0.95240165
98JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.95145563
99GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.94827159
100STAT1_20625510_ChIP-Seq_HELA_Human0.93301189

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005377_hearing/vestibular/ear_phenot3.98378704
2MP0003878_abnormal_ear_physiology3.98378704
3MP0005670_abnormal_white_adipose3.87735363
4MP0003698_abnormal_male_reproductive3.74833257
5MP0005423_abnormal_somatic_nervous3.48377356
6MP0001929_abnormal_gametogenesis3.29510493
7MP0001348_abnormal_lacrimal_gland3.20098317
8MP0002822_catalepsy2.98184836
9MP0002653_abnormal_ependyma_morphology2.80464273
10MP0003646_muscle_fatigue2.61932806
11MP0002735_abnormal_chemical_nociception2.39103775
12MP0001501_abnormal_sleep_pattern2.25335434
13MP0002161_abnormal_fertility/fecundity2.05134332
14MP0005410_abnormal_fertilization10.2819945
15MP0002132_abnormal_respiratory_system1.98258637
16MP0008961_abnormal_basal_metabolism1.92957884
17MP0003959_abnormal_lean_body1.80813822
18MP0000678_abnormal_parathyroid_gland1.66596699
19MP0003136_yellow_coat_color1.64937963
20MP0001486_abnormal_startle_reflex1.60675904
21MP0002210_abnormal_sex_determination1.50777328
22MP0002249_abnormal_larynx_morphology1.47272591
23MP0003718_maternal_effect1.46201468
24MP0001485_abnormal_pinna_reflex1.44388829
25MP0004742_abnormal_vestibular_system1.35120420
26MP0005671_abnormal_response_to1.31658601
27MP0003011_delayed_dark_adaptation1.25953243
28MP0001963_abnormal_hearing_physiology1.22223578
29MP0000026_abnormal_inner_ear1.21531347
30MP0001968_abnormal_touch/_nociception1.19649428
31MP0006276_abnormal_autonomic_nervous1.16912323
32MP0003879_abnormal_hair_cell1.16120775
33MP0005551_abnormal_eye_electrophysiolog1.13589993
34MP0000733_abnormal_muscle_development1.06137209
35MP0001145_abnormal_male_reproductive1.04530331
36MP0003137_abnormal_impulse_conducting1.03723167
37MP0000653_abnormal_sex_gland1.02964343
38MP0002282_abnormal_trachea_morphology1.02257694
39MP0001879_abnormal_lymphatic_vessel0.99205318
40MP0008875_abnormal_xenobiotic_pharmacok0.96312749
41MP0010386_abnormal_urinary_bladder0.94042107
42MP0005171_absent_coat_pigmentation0.93779005
43MP0005395_other_phenotype0.91594403
44MP0009115_abnormal_fat_cell0.91172917
45MP0002138_abnormal_hepatobiliary_system0.89905359
46MP0002234_abnormal_pharynx_morphology0.89349835
47MP0005083_abnormal_biliary_tract0.88283676
48MP0002733_abnormal_thermal_nociception0.87915271
49MP0002229_neurodegeneration0.87476328
50MP0000534_abnormal_ureter_morphology0.85746488
51MP0005360_urolithiasis0.85222510
52MP0003866_abnormal_defecation0.84142301
53MP0002933_joint_inflammation0.83906481
54MP0001881_abnormal_mammary_gland0.83896359
55MP0005645_abnormal_hypothalamus_physiol0.83260498
56MP0002102_abnormal_ear_morphology0.81644966
57MP0005310_abnormal_salivary_gland0.80729747
58MP0000230_abnormal_systemic_arterial0.80202265
59MP0001765_abnormal_ion_homeostasis0.79757893
60MP0000049_abnormal_middle_ear0.79204106
61MP0009278_abnormal_bone_marrow0.76845341
62MP0003950_abnormal_plasma_membrane0.74640039
63MP0005379_endocrine/exocrine_gland_phen0.72536576
64MP0001529_abnormal_vocalization0.72285541
65MP0004133_heterotaxia0.71532456
66MP0005266_abnormal_metabolism0.70081439
67MP0001970_abnormal_pain_threshold0.65875945
68MP0002067_abnormal_sensory_capabilities0.64357776
69MP0004233_abnormal_muscle_weight0.64011027
70MP0002136_abnormal_kidney_physiology0.63586763
71MP0001873_stomach_inflammation0.62714271
72MP0009384_cardiac_valve_regurgitation0.62431997
73MP0005666_abnormal_adipose_tissue0.61395392
74MP0002932_abnormal_joint_morphology0.61056179
75MP0002108_abnormal_muscle_morphology0.61010779
76MP0004085_abnormal_heartbeat0.60486063
77MP0002168_other_aberrant_phenotype0.60114756
78MP0002127_abnormal_cardiovascular_syste0.59946372
79MP0005451_abnormal_body_composition0.59537641
80MP0009745_abnormal_behavioral_response0.58081927
81MP0000955_abnormal_spinal_cord0.57419105
82MP0008770_decreased_survivor_rate0.56207593
83MP0001800_abnormal_humoral_immune0.55985304
84MP0005623_abnormal_meninges_morphology0.55532269
85MP0005332_abnormal_amino_acid0.55476172
86MP0002557_abnormal_social/conspecific_i0.54721348
87MP0000569_abnormal_digit_pigmentation0.53134562
88MP0003699_abnormal_female_reproductive0.51668306
89MP0002909_abnormal_adrenal_gland0.50533390
90MP0003045_fibrosis0.49932588
91MP0003283_abnormal_digestive_organ0.49873981
92MP0010368_abnormal_lymphatic_system0.49577884
93MP0005248_abnormal_Harderian_gland0.49181570
94MP0003763_abnormal_thymus_physiology0.49109639
95MP0005085_abnormal_gallbladder_physiolo0.48176787
96MP0002160_abnormal_reproductive_system0.48035941
97MP0002723_abnormal_immune_serum0.47139084
98MP0002736_abnormal_nociception_after0.47043457
99MP0002277_abnormal_respiratory_mucosa0.44507548
100MP0005535_abnormal_body_temperature0.43810986

Predicted human phenotypes

RankGene SetZ-score
1Severe visual impairment (HP:0001141)8.44517362
2Dynein arm defect of respiratory motile cilia (HP:0012255)6.90013448
3Absent/shortened dynein arms (HP:0200106)6.90013448
4Attenuation of retinal blood vessels (HP:0007843)4.23746092
5Increased IgE level (HP:0003212)4.19534159
6Asymmetric septal hypertrophy (HP:0001670)4.04178278
7Abnormal respiratory motile cilium morphology (HP:0005938)3.84644175
8Abnormal respiratory epithelium morphology (HP:0012253)3.84644175
9Sensory axonal neuropathy (HP:0003390)3.74653198
10Abnormal respiratory motile cilium physiology (HP:0012261)3.63764210
11Abnormal ciliary motility (HP:0012262)3.59433436
12Tubular atrophy (HP:0000092)3.56471789
13Chronic hepatic failure (HP:0100626)3.46080565
14Hypoplastic ischia (HP:0003175)3.43884268
15Enlarged epiphyses (HP:0010580)3.42516553
16Bony spicule pigmentary retinopathy (HP:0007737)3.41900753
17Hyperkalemia (HP:0002153)3.38153793
18Abnormal rod and cone electroretinograms (HP:0008323)3.18080696
19Nephronophthisis (HP:0000090)3.08950832
20Stage 5 chronic kidney disease (HP:0003774)3.05371347
21Abnormality of the ischium (HP:0003174)3.03303035
22Polydipsia (HP:0001959)2.97765412
23Abnormal drinking behavior (HP:0030082)2.97765412
24Hypoplasia of the thymus (HP:0000778)2.96285667
25Parkinsonism with favorable response to dopaminergic medication (HP:0002548)2.91640556
26Tubulointerstitial nephritis (HP:0001970)2.88854891
27Respiratory insufficiency due to defective ciliary clearance (HP:0200073)2.88633474
28Tubulointerstitial abnormality (HP:0001969)2.81078471
29True hermaphroditism (HP:0010459)2.78140987
30Aplasia/Hypoplasia of the pubic bone (HP:0009104)2.77544604
31Pancreatic fibrosis (HP:0100732)2.74666874
32Pancreatic cysts (HP:0001737)2.70602608
33Abnormality of the nasal septum (HP:0000419)2.69951227
34Potter facies (HP:0002009)2.64990834
35Facial shape deformation (HP:0011334)2.64990834
36Slow saccadic eye movements (HP:0000514)2.64096069
37Abnormal urine output (HP:0012590)2.63148447
38Abnormality of macular pigmentation (HP:0008002)2.61605407
39Abnormality of the renal medulla (HP:0100957)2.60750222
40Male infertility (HP:0003251)2.58653144
41Tubulointerstitial fibrosis (HP:0005576)2.58267570
42Bell-shaped thorax (HP:0001591)2.57389360
43Renovascular hypertension (HP:0100817)2.56828421
44Hypoalbuminemia (HP:0003073)2.51414723
45Abnormal albumin level (HP:0012116)2.51414723
46Cerebral hypomyelination (HP:0006808)2.51185743
47Recurrent corneal erosions (HP:0000495)2.50267223
48Aplasia/Hypoplasia of the earlobes (HP:0009906)2.48951174
49Infertility (HP:0000789)2.48374778
50Polyuria (HP:0000103)2.44419057
51Progressive cerebellar ataxia (HP:0002073)2.38703968
52Focal segmental glomerulosclerosis (HP:0000097)2.33199551
53Abnormality of the epiphysis of the femoral head (HP:0010574)2.33177704
54Spastic paraparesis (HP:0002313)2.31860659
55Resting tremor (HP:0002322)2.30882812
56Nasal polyposis (HP:0100582)2.28877024
57Abnormality of the femoral head (HP:0003368)2.27947559
58Menstrual irregularities (HP:0000858)2.22854259
59Abnormal spermatogenesis (HP:0008669)2.21587515
60Azoospermia (HP:0000027)2.19363729
61Abnormality of renal excretion (HP:0011036)2.18680529
62Flat capital femoral epiphysis (HP:0003370)2.17706616
63Amelogenesis imperfecta (HP:0000705)2.17270602
64Retinal atrophy (HP:0001105)2.16158062
65Genetic anticipation (HP:0003743)2.13194903
66Abnormality involving the epiphyses of the lower limbs (HP:0006500)2.13084970
67Abnormality of femoral epiphyses (HP:0006499)2.13084970
68Congenital hepatic fibrosis (HP:0002612)2.12559222
69Occipital encephalocele (HP:0002085)2.12258481
70Decreased central vision (HP:0007663)2.11926119
71Cystic liver disease (HP:0006706)2.10320317
72Abnormality of the renal cortex (HP:0011035)2.02542643
73Elevated erythrocyte sedimentation rate (HP:0003565)2.01576473
74Cerebellar dysplasia (HP:0007033)2.01334234
75Prostate neoplasm (HP:0100787)2.00158457
76Generalized aminoaciduria (HP:0002909)1.96812792
77Pigmentary retinal degeneration (HP:0001146)1.96477230
78Abnormality of the costochondral junction (HP:0000919)1.96058576
79Abnormality of potassium homeostasis (HP:0011042)1.95684248
80Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)1.95072145
81Absent epiphyses (HP:0010577)1.95072145
82Congenital sensorineural hearing impairment (HP:0008527)1.93433400
83Renal dysplasia (HP:0000110)1.92071445
84Glomerulosclerosis (HP:0000096)1.89201466
85Impulsivity (HP:0100710)1.87800639
86Sclerocornea (HP:0000647)1.87767197
87Amblyopia (HP:0000646)1.87568001
88Abnormality of the nasal mucosa (HP:0000433)1.84992740
89Cone-rod dystrophy (HP:0000548)1.81266967
90Osteomalacia (HP:0002749)1.79765530
91Bulbous nose (HP:0000414)1.77886637
92Mixed hearing impairment (HP:0000410)1.77824808
93Optic nerve hypoplasia (HP:0000609)1.77653217
94Progressive sensorineural hearing impairment (HP:0000408)1.74280845
95Portal hypertension (HP:0001409)1.73116941
96Flattened epiphyses (HP:0003071)1.71257014
97Rib fusion (HP:0000902)1.70910253
98Atelectasis (HP:0100750)1.70273687
99Bowel incontinence (HP:0002607)1.68276402
100Macular degeneration (HP:0000608)1.67691822

Predicted kinase interactions (KEA)

RankGene SetZ-score
1PLK46.22359101
2TESK14.72685044
3MAP4K24.28587979
4DDR23.71586831
5MAPK153.63598636
6TESK23.54965915
7PNCK3.51936376
8INSRR2.51279933
9BRD42.40922498
10TLK12.32232056
11PRKD32.28975473
12TXK2.16287132
13CDK122.14227668
14SIK21.93565098
15STK381.80663360
16STK38L1.79380486
17MST1R1.77213215
18CAMK1G1.62848083
19ZAK1.34903720
20LATS11.33433047
21PLK21.29901189
22TAOK31.24698808
23ICK1.19503343
24NEK61.17472507
25BRSK21.14745902
26PDPK11.12829151
27PDK11.08765442
28KDR1.07387452
29CAMK1D1.06937650
30MAP4K11.04010732
31BMX1.02530659
32LATS20.93024173
33ADRBK20.89356409
34PIK3CG0.88596416
35CDK70.86693140
36VRK10.86591367
37PIM20.85851698
38PTK2B0.84587790
39MAP2K20.83857134
40ACVR1B0.82137669
41KSR20.82127891
42MAPK110.79635665
43IRAK40.77614148
44PINK10.74087669
45WNK10.73987470
46DYRK1B0.73056016
47BMPR1B0.69926408
48PRKAA20.67424500
49MAPKAPK50.66792203
50MTOR0.66019240
51RPS6KA10.62537368
52WNK40.61473818
53NME10.61316463
54MARK30.60001813
55TEC0.59061921
56IKBKB0.56764683
57MAP3K60.56060864
58ITK0.55456191
59GRK60.54611883
60CAMKK20.52784758
61ZAP700.52189602
62BRSK10.52167856
63BLK0.52045787
64PRKAA10.50111974
65MAP3K110.49241362
66MAPKAPK30.47802132
67ROCK10.47153569
68MET0.46992875
69RPS6KA20.46646145
70BCKDK0.46245362
71TRPM70.46142792
72RPS6KA60.44670596
73CAMK10.44574762
74RPS6KA50.42798738
75PKN10.42723005
76MAPK10.41050250
77MAPK80.40851049
78CDK20.39109821
79CDK30.36920780
80SYK0.36417937
81TYRO30.36208773
82IKBKE0.35588725
83CHUK0.35514537
84GSK3B0.35296833
85RPS6KC10.31862504
86RPS6KL10.31862504
87MAPKAPK20.31792745
88NEK90.29114923
89CDK40.28852152
90NEK20.28522808
91PRKG10.27687925
92MAP3K70.27613435
93TIE10.26741972
94NLK0.26516970
95AURKA0.26322228
96BTK0.23831111
97CDK10.23360812
98GRK70.23006439
99MAP3K90.22935033
100RAF10.22029875

Predicted pathways (KEGG)

RankGene SetZ-score
1Synthesis and degradation of ketone bodies_Homo sapiens_hsa000726.67332542
2Fatty acid biosynthesis_Homo sapiens_hsa000614.63952501
3Olfactory transduction_Homo sapiens_hsa047402.99931467
4Butanoate metabolism_Homo sapiens_hsa006502.71051785
5Systemic lupus erythematosus_Homo sapiens_hsa053222.34125089
6Taste transduction_Homo sapiens_hsa047422.02483242
7Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.99213193
8Antigen processing and presentation_Homo sapiens_hsa046121.96811298
9Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.87220058
10Sulfur relay system_Homo sapiens_hsa041221.66825080
11Primary immunodeficiency_Homo sapiens_hsa053401.62887841
12Graft-versus-host disease_Homo sapiens_hsa053321.60168017
13Dorso-ventral axis formation_Homo sapiens_hsa043201.56136123
14Alcoholism_Homo sapiens_hsa050341.51764474
15Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.35998414
16Autoimmune thyroid disease_Homo sapiens_hsa053201.33632055
17Allograft rejection_Homo sapiens_hsa053301.32390127
18Adipocytokine signaling pathway_Homo sapiens_hsa049201.32125410
19Longevity regulating pathway - multiple species_Homo sapiens_hsa042131.29759680
20Notch signaling pathway_Homo sapiens_hsa043301.28716840
21Phototransduction_Homo sapiens_hsa047441.27058469
22Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.24598596
23Viral carcinogenesis_Homo sapiens_hsa052031.20207545
24Glycerophospholipid metabolism_Homo sapiens_hsa005641.17239532
25Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.15214513
26Progesterone-mediated oocyte maturation_Homo sapiens_hsa049141.12357506
27Nitrogen metabolism_Homo sapiens_hsa009101.12175436
28Phenylalanine metabolism_Homo sapiens_hsa003601.06752990
29ABC transporters_Homo sapiens_hsa020101.04652536
30Salivary secretion_Homo sapiens_hsa049701.00461840
31Maturity onset diabetes of the young_Homo sapiens_hsa049500.99741756
32Non-homologous end-joining_Homo sapiens_hsa034500.99628480
33Fanconi anemia pathway_Homo sapiens_hsa034600.96369711
34Basal transcription factors_Homo sapiens_hsa030220.96322394
35Selenocompound metabolism_Homo sapiens_hsa004500.95611070
36Influenza A_Homo sapiens_hsa051640.94352297
37Calcium signaling pathway_Homo sapiens_hsa040200.92221154
38Type I diabetes mellitus_Homo sapiens_hsa049400.91345599
39Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.91202810
40Arginine and proline metabolism_Homo sapiens_hsa003300.91144498
41T cell receptor signaling pathway_Homo sapiens_hsa046600.86304880
42Protein digestion and absorption_Homo sapiens_hsa049740.85977112
43Type II diabetes mellitus_Homo sapiens_hsa049300.84118836
44Measles_Homo sapiens_hsa051620.83116826
45Linoleic acid metabolism_Homo sapiens_hsa005910.82315946
46Basal cell carcinoma_Homo sapiens_hsa052170.79227253
47Acute myeloid leukemia_Homo sapiens_hsa052210.77432915
48Propanoate metabolism_Homo sapiens_hsa006400.76443677
49MAPK signaling pathway_Homo sapiens_hsa040100.76176281
50Cholinergic synapse_Homo sapiens_hsa047250.74443987
51cAMP signaling pathway_Homo sapiens_hsa040240.74007453
52Fatty acid degradation_Homo sapiens_hsa000710.73548871
53Transcriptional misregulation in cancer_Homo sapiens_hsa052020.71842753
54Chemical carcinogenesis_Homo sapiens_hsa052040.71456258
55Viral myocarditis_Homo sapiens_hsa054160.69362295
56Glycosaminoglycan degradation_Homo sapiens_hsa005310.68051929
57RNA transport_Homo sapiens_hsa030130.63796247
58Tyrosine metabolism_Homo sapiens_hsa003500.63392238
59Intestinal immune network for IgA production_Homo sapiens_hsa046720.62442791
60Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.60373003
61Hedgehog signaling pathway_Homo sapiens_hsa043400.60262636
62Circadian rhythm_Homo sapiens_hsa047100.58878909
63Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.58547121
64NF-kappa B signaling pathway_Homo sapiens_hsa040640.57375367
65Lysine degradation_Homo sapiens_hsa003100.57362908
66Morphine addiction_Homo sapiens_hsa050320.56831012
67Endocytosis_Homo sapiens_hsa041440.54967780
68alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.53786222
69Glycerolipid metabolism_Homo sapiens_hsa005610.53783514
70Jak-STAT signaling pathway_Homo sapiens_hsa046300.53761478
71Retinol metabolism_Homo sapiens_hsa008300.53311828
72Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.53096402
73NOD-like receptor signaling pathway_Homo sapiens_hsa046210.53062452
74Purine metabolism_Homo sapiens_hsa002300.51979815
75Cardiac muscle contraction_Homo sapiens_hsa042600.50526156
76Legionellosis_Homo sapiens_hsa051340.48971934
77Tryptophan metabolism_Homo sapiens_hsa003800.48377749
78VEGF signaling pathway_Homo sapiens_hsa043700.48054527
79Bile secretion_Homo sapiens_hsa049760.45855006
80Herpes simplex infection_Homo sapiens_hsa051680.45582398
81Carbohydrate digestion and absorption_Homo sapiens_hsa049730.45413703
82Histidine metabolism_Homo sapiens_hsa003400.45186434
83PPAR signaling pathway_Homo sapiens_hsa033200.43947622
84Thyroid hormone signaling pathway_Homo sapiens_hsa049190.42733465
85Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.36963212
86Oxytocin signaling pathway_Homo sapiens_hsa049210.35830044
87Steroid hormone biosynthesis_Homo sapiens_hsa001400.35684934
88Glutamatergic synapse_Homo sapiens_hsa047240.35176222
89Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.34831731
90Aldosterone synthesis and secretion_Homo sapiens_hsa049250.34601489
91Gastric acid secretion_Homo sapiens_hsa049710.34075391
92Estrogen signaling pathway_Homo sapiens_hsa049150.33863079
93Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.33206860
94Serotonergic synapse_Homo sapiens_hsa047260.33060732
95Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.32291362
96Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.31655566
97Fatty acid metabolism_Homo sapiens_hsa012120.31212893
98FoxO signaling pathway_Homo sapiens_hsa040680.30973032
99Vascular smooth muscle contraction_Homo sapiens_hsa042700.30257587
100RNA polymerase_Homo sapiens_hsa030200.28997241

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