SLC36A1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the eukaryote-specific amino acid/auxin permease (AAAP) 1 transporter family. The encoded protein functions as a proton-dependent, small amino acid transporter. This gene is clustered with related family members on chromosome 5q33.1. Alternative splicing results in multiple transcript variants. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1glycosphingolipid catabolic process (GO:0046479)4.57388237
2response to peptidoglycan (GO:0032494)4.31011906
3neutrophil activation involved in immune response (GO:0002283)4.22266129
4glycolipid catabolic process (GO:0019377)4.17977685
5positive regulation by symbiont of host defense response (GO:0052509)4.07335438
6modulation by symbiont of host defense response (GO:0052031)4.07335438
7modulation by organism of immune response of other organism involved in symbiotic interaction (GO:004.07335438
8modulation by organism of defense response of other organism involved in symbiotic interaction (GO:04.07335438
9positive regulation by organism of defense response of other organism involved in symbiotic interact4.07335438
10modulation by symbiont of host immune response (GO:0052553)4.07335438
11macrophage activation involved in immune response (GO:0002281)3.92085365
12oligosaccharide catabolic process (GO:0009313)3.89245639
13negative regulation of interleukin-12 production (GO:0032695)3.86997980
14drug catabolic process (GO:0042737)3.80316455
15detection of molecule of bacterial origin (GO:0032490)3.77463826
16negative regulation of erythrocyte differentiation (GO:0045647)3.68295265
17triglyceride-rich lipoprotein particle remodeling (GO:0034370)3.68002482
18cellular response to thyroid hormone stimulus (GO:0097067)3.64425550
19ceramide catabolic process (GO:0046514)3.59144831
20intestinal cholesterol absorption (GO:0030299)3.57915302
21detection of other organism (GO:0098543)3.55057545
22regulation of mast cell degranulation (GO:0043304)3.53401863
23protein localization to endosome (GO:0036010)3.52033187
24regulation of leukocyte degranulation (GO:0043300)3.50721717
25erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)3.42035062
26L-phenylalanine catabolic process (GO:0006559)3.42035062
27phospholipid efflux (GO:0033700)3.38960288
28detection of external biotic stimulus (GO:0098581)3.38562473
29positive regulation of leukocyte degranulation (GO:0043302)3.38296957
30exogenous drug catabolic process (GO:0042738)3.33571098
31L-phenylalanine metabolic process (GO:0006558)3.29321969
32erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)3.29321969
33amino sugar catabolic process (GO:0046348)3.29277629
34barbed-end actin filament capping (GO:0051016)3.26916045
35negative regulation of cell killing (GO:0031342)3.23726495
36negative regulation of leukocyte mediated cytotoxicity (GO:0001911)3.23726495
37regulation of myeloid leukocyte mediated immunity (GO:0002886)3.20991037
38urea metabolic process (GO:0019627)3.20186378
39urea cycle (GO:0000050)3.20186378
40regulation of mononuclear cell migration (GO:0071675)3.19977568
41regulation of mast cell activation involved in immune response (GO:0033006)3.19197589
42detection of bacterium (GO:0016045)3.18017987
43antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G3.17592599
44cellular extravasation (GO:0045123)3.16956963
45negative regulation of amyloid precursor protein catabolic process (GO:1902992)3.15780720
46synaptic vesicle maturation (GO:0016188)3.15131504
47regulation of macrophage chemotaxis (GO:0010758)3.14344654
48positive regulation of gamma-delta T cell activation (GO:0046645)3.13804852
49membrane lipid catabolic process (GO:0046466)3.13242922
50high-density lipoprotein particle remodeling (GO:0034375)3.10556443
51sodium ion export (GO:0071436)3.09015014
52intestinal absorption (GO:0050892)3.06531902
53cholesterol efflux (GO:0033344)3.05663577
54sphingolipid catabolic process (GO:0030149)3.05133746
55lipopolysaccharide-mediated signaling pathway (GO:0031663)3.04721185
56peptide catabolic process (GO:0043171)3.04347999
57reverse cholesterol transport (GO:0043691)3.02100459
58regulation of short-term neuronal synaptic plasticity (GO:0048172)3.01775698
59cellular potassium ion homeostasis (GO:0030007)3.01145977
60aromatic amino acid family catabolic process (GO:0009074)2.99098236
61positive regulation of cellular amide metabolic process (GO:0034250)2.99003865
62positive regulation of mast cell activation involved in immune response (GO:0033008)2.98085347
63positive regulation of mast cell degranulation (GO:0043306)2.98085347
64adhesion of symbiont to host cell (GO:0044650)2.97380832
65virion attachment to host cell (GO:0019062)2.97380832
66regulation of regulated secretory pathway (GO:1903305)2.96049856
67mannose metabolic process (GO:0006013)2.95185389
68regulation of cholesterol homeostasis (GO:2000188)2.95077516
69response to thyroid hormone (GO:0097066)2.93356906
70regulation of interferon-beta biosynthetic process (GO:0045357)2.93277788
71peptidyl-glutamic acid carboxylation (GO:0017187)2.93202352
72protein carboxylation (GO:0018214)2.93202352
73regulation of macrophage cytokine production (GO:0010935)2.91471078
74detection of biotic stimulus (GO:0009595)2.90745112
75granulocyte activation (GO:0036230)2.88725802
76dicarboxylic acid biosynthetic process (GO:0043650)2.87384318
77macrophage activation (GO:0042116)2.87378233
78positive regulation of calcium ion-dependent exocytosis (GO:0045956)2.87376921
79positive regulation of mast cell activation (GO:0033005)2.87215106
80fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)2.87209791
81nitrogen cycle metabolic process (GO:0071941)2.85761188
82negative regulation of sterol transport (GO:0032372)2.85397269
83negative regulation of cholesterol transport (GO:0032375)2.85397269
84response to laminar fluid shear stress (GO:0034616)2.84863769
85alpha-linolenic acid metabolic process (GO:0036109)2.84584464
86N-acetylneuraminate metabolic process (GO:0006054)2.84052878
87lysine metabolic process (GO:0006553)2.82249163
88lysine catabolic process (GO:0006554)2.82249163
89positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)2.81956724
90drug transmembrane transport (GO:0006855)2.81189774
91response to immune response of other organism involved in symbiotic interaction (GO:0052564)2.80439109
92response to host immune response (GO:0052572)2.80439109
93immunoglobulin mediated immune response (GO:0016064)2.79379551
94regulation of cholesterol esterification (GO:0010872)2.76966204
95positive regulation of myeloid leukocyte mediated immunity (GO:0002888)2.76358040
96regulation of early endosome to late endosome transport (GO:2000641)2.75138504
97T-helper 1 type immune response (GO:0042088)2.74654552
98pinocytosis (GO:0006907)2.72673070
99antigen processing and presentation of endogenous peptide antigen (GO:0002483)2.72199909
100glutamate secretion (GO:0014047)2.71239434
101neutrophil activation (GO:0042119)2.69614232
102plasma lipoprotein particle assembly (GO:0034377)2.69025098
103kynurenine metabolic process (GO:0070189)2.68821448
104indole-containing compound catabolic process (GO:0042436)2.68074064
105indolalkylamine catabolic process (GO:0046218)2.68074064
106tryptophan catabolic process (GO:0006569)2.68074064
107plasma lipoprotein particle remodeling (GO:0034369)2.67679636
108protein-lipid complex remodeling (GO:0034368)2.67679636
109macromolecular complex remodeling (GO:0034367)2.67679636
110positive regulation of regulated secretory pathway (GO:1903307)2.67672138
111cysteine metabolic process (GO:0006534)2.67047082
112cellular modified amino acid catabolic process (GO:0042219)2.66933296
113adhesion of symbiont to host (GO:0044406)2.66767126
114regulation of T-helper 2 cell differentiation (GO:0045628)2.66729159
115regulation of systemic arterial blood pressure by renin-angiotensin (GO:0003081)2.66642795
116phospholipid homeostasis (GO:0055091)2.66422077
117negative regulation of toll-like receptor 4 signaling pathway (GO:0034144)2.64577885
118glutamate metabolic process (GO:0006536)2.64163340
119regulation of triglyceride catabolic process (GO:0010896)2.64028812
120response to host (GO:0075136)2.63489383
121response to host defenses (GO:0052200)2.63489383
122response to defenses of other organism involved in symbiotic interaction (GO:0052173)2.63489383
123antigen processing and presentation of endogenous antigen (GO:0019883)2.63259626
124positive regulation of synaptic transmission, dopaminergic (GO:0032226)2.62605005
125positive regulation of membrane protein ectodomain proteolysis (GO:0051044)2.62202006
126protein-lipid complex assembly (GO:0065005)2.61645915
127tryptophan metabolic process (GO:0006568)2.61202224
128neurotransmitter secretion (GO:0007269)2.60224068
129antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)2.60185723
130positive regulation of macrophage cytokine production (GO:0060907)2.59575494
131regulation of mast cell activation (GO:0033003)2.58027909
132synaptic vesicle exocytosis (GO:0016079)2.57864305
133fat-soluble vitamin biosynthetic process (GO:0042362)2.57059804
134detection of temperature stimulus involved in sensory perception (GO:0050961)2.56941319
135detection of temperature stimulus involved in sensory perception of pain (GO:0050965)2.56941319
136positive regulation of lipid catabolic process (GO:0050996)2.56848131
137positive regulation of Cdc42 GTPase activity (GO:0043089)2.55528332
138regulation of monocyte chemotaxis (GO:0090025)2.55179047
139myeloid cell activation involved in immune response (GO:0002275)2.54319621
140cell communication by electrical coupling involved in cardiac conduction (GO:0086064)2.53487956
141apoptotic cell clearance (GO:0043277)2.48653939
142locomotory exploration behavior (GO:0035641)2.48395551
143stress fiber assembly (GO:0043149)2.47835954
144gamma-aminobutyric acid transport (GO:0015812)2.45524127
145microglial cell activation (GO:0001774)2.44657288
146glyoxylate metabolic process (GO:0046487)2.44560428
147regulation of synaptic vesicle exocytosis (GO:2000300)2.44358256
148positive regulation of monocyte chemotaxis (GO:0090026)2.44136543
149regulation of cholesterol storage (GO:0010885)2.43925749
150sulfur amino acid catabolic process (GO:0000098)2.43290141
151detection of temperature stimulus (GO:0016048)2.41881155
152cellular ketone body metabolic process (GO:0046950)2.40601827
153positive regulation of syncytium formation by plasma membrane fusion (GO:0060143)2.40571246
154cell communication involved in cardiac conduction (GO:0086065)2.40379456
155regulation of superoxide anion generation (GO:0032928)2.40096001
156response to muramyl dipeptide (GO:0032495)2.40085582
157regulation of ARF protein signal transduction (GO:0032012)2.39627931
158negative regulation of toll-like receptor signaling pathway (GO:0034122)2.39611334
159positive regulation of receptor recycling (GO:0001921)2.39314219
160regulation of vitamin metabolic process (GO:0030656)2.38765574
161bile acid biosynthetic process (GO:0006699)2.38641309
162angiotensin maturation (GO:0002003)2.37297447
163vocalization behavior (GO:0071625)2.37088949
164* alanine transport (GO:0032328)2.36821522
165drug transport (GO:0015893)2.36699288
166negative regulation of cytokine production involved in immune response (GO:0002719)2.35969110
167respiratory burst (GO:0045730)2.35604480
168germinal center formation (GO:0002467)2.35152702
169complement activation, alternative pathway (GO:0006957)2.35128264
170flavonoid metabolic process (GO:0009812)2.35050852
171nucleobase catabolic process (GO:0046113)2.34914562
172negative regulation of protein localization to plasma membrane (GO:1903077)2.34179672
173lipoprotein metabolic process (GO:0042157)2.34001378
174coenzyme catabolic process (GO:0009109)2.33990188
175* proline transport (GO:0015824)2.33312652
176bile acid and bile salt transport (GO:0015721)2.32224345
177regulation of protein activation cascade (GO:2000257)2.32211989
178activation of protein kinase A activity (GO:0034199)2.30656440
179homocysteine metabolic process (GO:0050667)2.29578251
180cellular sodium ion homeostasis (GO:0006883)2.29042289
181synaptic vesicle docking involved in exocytosis (GO:0016081)2.28723016
182lipoprotein transport (GO:0042953)2.28697146
183plasma lipoprotein particle clearance (GO:0034381)2.27974219
184plasma lipoprotein particle organization (GO:0071827)2.26945817
185cholesterol transport (GO:0030301)2.26866660
186sterol transport (GO:0015918)2.26866660
187positive regulation of fatty acid biosynthetic process (GO:0045723)2.26855672
188protein-lipid complex subunit organization (GO:0071825)2.25375922
189macroautophagy (GO:0016236)2.22909508
190bile acid metabolic process (GO:0008206)2.21313989
191regulation of complement activation (GO:0030449)2.19535787
192membrane depolarization during action potential (GO:0086010)2.19104042
193triglyceride homeostasis (GO:0070328)2.18782093
194acylglycerol homeostasis (GO:0055090)2.18782093
195regulation of synaptic vesicle transport (GO:1902803)2.18215347
196sterol homeostasis (GO:0055092)2.17785548
197amino-acid betaine metabolic process (GO:0006577)2.16875376

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1ESR1_17901129_ChIP-ChIP_LIVER_Mouse4.01083596
2NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human3.27882783
3BP1_19119308_ChIP-ChIP_Hs578T_Human3.10434971
4* RXR_22158963_ChIP-Seq_LIVER_Mouse3.05151125
5IRF8_21731497_ChIP-ChIP_J774_Mouse3.01269155
6IRF8_22096565_ChIP-ChIP_GC-B_Human2.98533734
7NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse2.78013572
8LXR_22158963_ChIP-Seq_LIVER_Mouse2.62763794
9MYB_21317192_ChIP-Seq_ERMYB_Mouse2.58094698
10* PPARA_22158963_ChIP-Seq_LIVER_Mouse2.57484313
11MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.36407590
12VDR_24763502_ChIP-Seq_THP-1_Human2.34484377
13VDR_21846776_ChIP-Seq_THP-1_Human2.27585723
14NR1I2_20693526_ChIP-Seq_LIVER_Mouse2.14361270
15FOXO1_23066095_ChIP-Seq_LIVER_Mouse2.08549757
16GATA1_22025678_ChIP-Seq_K562_Human2.01198956
17RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human2.00499156
18DROSHA_22980978_ChIP-Seq_HELA_Human1.96738628
19VDR_24787735_ChIP-Seq_THP-1_Human1.93005760
20BRD4_27068464_Chip-Seq_AML-cells_Mouse1.92573114
21EZH2_22144423_ChIP-Seq_EOC_Human1.87752644
22ELK3_25401928_ChIP-Seq_HUVEC_Human1.85675881
23RARG_19884340_ChIP-ChIP_MEFs_Mouse1.82676956
24SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.77101374
25EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.76564010
26MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.76317985
27* STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.76251411
28TCF7_22412390_ChIP-Seq_EML_Mouse1.75626958
29THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.75114337
30TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.70109347
31SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.69972996
32MTF2_20144788_ChIP-Seq_MESCs_Mouse1.67539460
33SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.66959091
34TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.66509252
35EGR1_19374776_ChIP-ChIP_THP-1_Human1.63406677
36REST_21632747_ChIP-Seq_MESCs_Mouse1.60843232
37SCL_19346495_ChIP-Seq_HPC-7_Human1.58203719
38GBX2_23144817_ChIP-Seq_PC3_Human1.57907317
39RUNX1_22412390_ChIP-Seq_EML_Mouse1.55208259
40EZH2_18974828_ChIP-Seq_MESCs_Mouse1.54038890
41RNF2_18974828_ChIP-Seq_MESCs_Mouse1.54038890
42ESR2_21235772_ChIP-Seq_MCF-7_Human1.53317085
43KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.53305126
44RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.52869456
45JARID2_20075857_ChIP-Seq_MESCs_Mouse1.48875166
46TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.48342505
47RARB_27405468_Chip-Seq_BRAIN_Mouse1.48196929
48ERG_21242973_ChIP-ChIP_JURKAT_Human1.47855617
49SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.45857961
50STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.45704889
51* SPI1_23547873_ChIP-Seq_NB4_Human1.45375464
52STAT6_21828071_ChIP-Seq_BEAS2B_Human1.43468260
53CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.42601873
54CLOCK_20551151_ChIP-Seq_293T_Human1.41656650
55STAT4_19710469_ChIP-ChIP_TH1__Mouse1.38401389
56TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.38108439
57E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.38089616
58IKZF1_21737484_ChIP-ChIP_HCT116_Human1.37964463
59CDX2_19796622_ChIP-Seq_MESCs_Mouse1.36997940
60SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.33394723
61SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.33119502
62CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.31910673
63KDM2B_26808549_Chip-Seq_K562_Human1.31733575
64JARID2_20064375_ChIP-Seq_MESCs_Mouse1.31406600
65REST_18959480_ChIP-ChIP_MESCs_Mouse1.31381072
66FOXA2_19822575_ChIP-Seq_HepG2_Human1.31127001
67LXR_22292898_ChIP-Seq_THP-1_Human1.29717874
68KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.28416612
69SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.27570521
70* NR3C1_23031785_ChIP-Seq_PC12_Mouse1.27014421
71PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.26860789
72PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.25542142
73CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.25204087
74EGR1_23403033_ChIP-Seq_LIVER_Mouse1.24266180
75PU_27001747_Chip-Seq_BMDM_Mouse1.23645767
76* Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.23156486
77GATA1_22383799_ChIP-Seq_G1ME_Mouse1.23091270
78RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.22931936
79ZNF217_24962896_ChIP-Seq_MCF-7_Human1.22709652
80TP63_17297297_ChIP-ChIP_HaCaT_Human1.21925561
81SUZ12_27294783_Chip-Seq_ESCs_Mouse1.21165481
82MAF_26560356_Chip-Seq_TH1_Human1.18695915
83* BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.18068092
84MYC_22102868_ChIP-Seq_BL_Human1.16927406
85MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.16564088
86PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.16206216
87FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.16202750
88EZH2_27294783_Chip-Seq_ESCs_Mouse1.15720603
89SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.15610758
90DNAJC2_21179169_ChIP-ChIP_NT2_Human1.13414687
91KDM2B_26808549_Chip-Seq_SUP-B15_Human1.13275406
92VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.10528206
93PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse1.10338084
94CDX2_20551321_ChIP-Seq_CACO-2_Human1.10058147
95FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.10045821
96RUNX_20019798_ChIP-Seq_JUKART_Human1.10028956
97ESR1_20079471_ChIP-ChIP_T-47D_Human1.09562572
98KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.08932579
99WT1_25993318_ChIP-Seq_PODOCYTE_Human1.08830219
100* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.08445558
101LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.07842632
102* GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.07452384
103ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.07423363
104P300_27058665_Chip-Seq_ZR-75-30cells_Human1.06314983
105KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.06106229
106* GATA2_22383799_ChIP-Seq_G1ME_Mouse1.04298190
107CTCF_27219007_Chip-Seq_ERYTHROID_Human1.03777985
108SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.03297685
109NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.03132122
110TCF7L2_21901280_ChIP-Seq_H4IIE_Rat1.03034018
111RNF2_27304074_Chip-Seq_ESCs_Mouse1.02684911
112PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.00553330
113AHR_22903824_ChIP-Seq_MCF-7_Human0.99735528
114UTX_26944678_Chip-Seq_JUKART_Human0.98631657
115SMAD4_21741376_ChIP-Seq_HESCs_Human0.98389259
116NFIB_24661679_ChIP-Seq_LUNG_Mouse0.98357182
117SMAD4_21799915_ChIP-Seq_A2780_Human0.98007840
118CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse0.97632813
119CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse0.96348422
120ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human0.96017171
121GATA2_20887958_ChIP-Seq_HPC-7_Mouse0.96015365
122* GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.95386191
123ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.95235710
124EED_16625203_ChIP-ChIP_MESCs_Mouse0.94628637
125ESR1_21235772_ChIP-Seq_MCF-7_Human0.94226439
126KDM2B_26808549_Chip-Seq_JURKAT_Human0.93542643
127STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse0.93328278
128GATA1_19941827_ChIP-Seq_MEL_Mouse0.92985720
129SPI1_23127762_ChIP-Seq_K562_Human0.91672692
130SMARCD1_25818293_ChIP-Seq_ESCs_Mouse0.91298041
131* ESRRB_18555785_ChIP-Seq_MESCs_Mouse0.91253822
132SOX2_21211035_ChIP-Seq_LN229_Gbm0.90716489
133* SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse0.90132046
134GATA1_19941826_ChIP-Seq_K562_Human0.90066019
135SMAD3_21741376_ChIP-Seq_HESCs_Human0.89988411
136NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse0.89632969
137* GATA2_19941826_ChIP-Seq_K562_Human0.89252162
138CTCF_27219007_Chip-Seq_Bcells_Human0.88409905
139ARNT_22903824_ChIP-Seq_MCF-7_Human0.88313246
140AR_19668381_ChIP-Seq_PC3_Human0.86813668
141EZH2_27304074_Chip-Seq_ESCs_Mouse0.86410062
142RCOR2_21632747_ChIP-Seq_MESCs_Mouse0.85904083
143PIAS1_25552417_ChIP-Seq_VCAP_Human0.84900371
144AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.83854005
145PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse0.83632526
146GATA2_21666600_ChIP-Seq_HMVEC_Human0.82835209
147BCAT_22108803_ChIP-Seq_LS180_Human0.82701399
148SMAD_19615063_ChIP-ChIP_OVARY_Human0.82655220
149* HNF4A_19822575_ChIP-Seq_HepG2_Human0.82610138
150SOX2_27498859_Chip-Seq_STOMACH_Mouse0.82522145
151STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse0.82513265
152PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human0.82264143
153RXR_22108803_ChIP-Seq_LS180_Human0.82159565
154TP53_16413492_ChIP-PET_HCT116_Human0.82136038
155IRF1_21803131_ChIP-Seq_MONOCYTES_Human0.80117407
156CTNNB1_20460455_ChIP-Seq_HCT116_Human0.79514031
157SMAD2/3_21741376_ChIP-Seq_EPCs_Human0.77839010
158* AR_25329375_ChIP-Seq_VCAP_Human0.77733219
159KDM2B_26808549_Chip-Seq_DND41_Human0.77703467
160STAT3_23295773_ChIP-Seq_U87_Human0.77381802
161ZFP281_18757296_ChIP-ChIP_E14_Mouse0.77335689
162* IRF8_27001747_Chip-Seq_BMDM_Mouse0.77068954
163NR4A2_19515692_ChIP-ChIP_MN9D_Mouse0.76953844
164TET1_21490601_ChIP-Seq_MESCs_Mouse0.76329651
165RCOR3_21632747_ChIP-Seq_MESCs_Mouse0.76162456
166RACK7_27058665_Chip-Seq_MCF-7_Human0.74468808
167AR_21572438_ChIP-Seq_LNCaP_Human0.74270024

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005360_urolithiasis5.41940409
2MP0002139_abnormal_hepatobiliary_system4.33698999
3MP0005085_abnormal_gallbladder_physiolo3.53072986
4MP0004859_abnormal_synaptic_plasticity3.12964443
5MP0003436_decreased_susceptibility_to3.12405785
6MP0002822_catalepsy3.08957960
7MP0005365_abnormal_bile_salt3.00442267
8MP0006082_CNS_inflammation2.86785539
9MP0004858_abnormal_nervous_system2.69767800
10MP0001968_abnormal_touch/_nociception2.68595426
11MP0008875_abnormal_xenobiotic_pharmacok2.68161470
12MP0009840_abnormal_foam_cell2.60581603
13MP0002735_abnormal_chemical_nociception2.55145734
14MP0003252_abnormal_bile_duct2.52848358
15MP0003724_increased_susceptibility_to2.48505813
16MP0005451_abnormal_body_composition2.47877386
17MP0004270_analgesia2.45577526
18MP0002736_abnormal_nociception_after2.45141510
19MP0010329_abnormal_lipoprotein_level2.42627176
20MP0002419_abnormal_innate_immunity2.41941615
21MP0008260_abnormal_autophagy2.30396908
22MP0000569_abnormal_digit_pigmentation2.25320844
23MP0003172_abnormal_lysosome_physiology2.15635220
24MP0001666_abnormal_nutrient_absorption2.13006421
25MP0005083_abnormal_biliary_tract2.09819105
26MP0002733_abnormal_thermal_nociception2.08598406
27MP0001835_abnormal_antigen_presentation2.06577812
28MP0003183_abnormal_peptide_metabolism1.99296661
29MP0009785_altered_susceptibility_to1.95019002
30MP0002148_abnormal_hypersensitivity_rea1.94397534
31MP0003191_abnormal_cellular_cholesterol1.93716109
32MP0005025_abnormal_response_to1.92132964
33MP0003635_abnormal_synaptic_transmissio1.89359774
34MP0002998_abnormal_bone_remodeling1.88879091
35MP0001533_abnormal_skeleton_physiology1.85392727
36MP0002734_abnormal_mechanical_nocicepti1.79010582
37MP0002909_abnormal_adrenal_gland1.76601539
38MP0005000_abnormal_immune_tolerance1.76253776
39MP0009780_abnormal_chondrocyte_physiolo1.74955286
40MP0000604_amyloidosis1.70008552
41MP0005332_abnormal_amino_acid1.69648310
42MP0000343_altered_response_to1.69591941
43MP0001970_abnormal_pain_threshold1.68684664
44MP0003329_amyloid_beta_deposits1.68540378
45MP0000685_abnormal_immune_system1.64497243
46MP0009278_abnormal_bone_marrow1.63794103
47MP0010155_abnormal_intestine_physiology1.61328540
48MP0003828_pulmonary_edema1.61214474
49MP0009745_abnormal_behavioral_response1.57351268
50MP0001790_abnormal_immune_system1.57017454
51MP0005387_immune_system_phenotype1.57017454
52MP0005058_abnormal_lysosome_morphology1.56874250
53MP0002064_seizures1.55875583
54MP0008961_abnormal_basal_metabolism1.52166721
55MP0005409_darkened_coat_color1.51540512
56MP0005310_abnormal_salivary_gland1.50632784
57MP0002452_abnormal_antigen_presenting1.50508578
58MP0004947_skin_inflammation1.50419737
59MP0002063_abnormal_learning/memory/cond1.45890993
60MP0008438_abnormal_cutaneous_collagen1.44339901
61MP0004019_abnormal_vitamin_homeostasis1.42795412
62MP0000858_altered_metastatic_potential1.42718361
63MP0002118_abnormal_lipid_homeostasis1.42548278
64MP0005671_abnormal_response_to1.40529218
65MP0002723_abnormal_immune_serum1.39468984
66MP0001845_abnormal_inflammatory_respons1.38989760
67MP0001501_abnormal_sleep_pattern1.38360793
68MP0010386_abnormal_urinary_bladder1.37602557
69MP0003300_gastrointestinal_ulcer1.37009443
70MP0003448_altered_tumor_morphology1.35726491
71MP0009046_muscle_twitch1.35659089
72MP0000538_abnormal_urinary_bladder1.33631350
73MP0003868_abnormal_feces_composition1.32377681
74MP0003633_abnormal_nervous_system1.31656915
75MP0006276_abnormal_autonomic_nervous1.31118031
76MP0002572_abnormal_emotion/affect_behav1.30090431
77MP0001819_abnormal_immune_cell1.29703519
78MP0002420_abnormal_adaptive_immunity1.29348673
79MP0008469_abnormal_protein_level1.28152746
80MP0005397_hematopoietic_system_phenotyp1.26619559
81MP0001545_abnormal_hematopoietic_system1.26619559
82MP0008874_decreased_physiological_sensi1.26253750
83MP0003075_altered_response_to1.26172082
84MP0005535_abnormal_body_temperature1.23314766
85MP0008004_abnormal_stomach_pH1.22515663
86MP0001800_abnormal_humoral_immune1.22106044
87MP0004043_abnormal_pH_regulation1.21364290
88MP0003045_fibrosis1.20479855
89MP0003091_abnormal_cell_migration1.19771394
90MP0000920_abnormal_myelination1.19158037
91MP0002272_abnormal_nervous_system1.17583125
92MP0003566_abnormal_cell_adhesion1.17082303
93MP0003879_abnormal_hair_cell1.16051393
94MP0000609_abnormal_liver_physiology1.15957368
95MP0001440_abnormal_grooming_behavior1.15806437
96MP0003195_calcinosis1.15385723
97MP0002877_abnormal_melanocyte_morpholog1.14923724
98MP0002405_respiratory_system_inflammati1.13467864
99MP0000678_abnormal_parathyroid_gland1.12662492
100MP0005584_abnormal_enzyme/coenzyme_acti1.12453491
101MP0010234_abnormal_vibrissa_follicle1.11244260
102MP0003453_abnormal_keratinocyte_physiol1.11183786
103MP0006054_spinal_hemorrhage1.11157072
104MP0003690_abnormal_glial_cell1.09487857
105MP0001958_emphysema1.07937653
106MP0003279_aneurysm1.06896463
107MP0001849_ear_inflammation1.06670865
108MP0009643_abnormal_urine_homeostasis1.05572326
109MP0005319_abnormal_enzyme/_coenzyme1.03013656
110MP0003656_abnormal_erythrocyte_physiolo1.02455597
111MP0002067_abnormal_sensory_capabilities1.01530828
112MP0005076_abnormal_cell_differentiation1.01179650
113MP0005257_abnormal_intraocular_pressure1.00487635
114MP0005464_abnormal_platelet_physiology1.00031222
115MP0001756_abnormal_urination0.99762668
116MP0004811_abnormal_neuron_physiology0.99286494
117MP0008872_abnormal_physiological_respon0.98946433
118MP0002896_abnormal_bone_mineralization0.98633071
119MP0003705_abnormal_hypodermis_morpholog0.98166718
120MP0001765_abnormal_ion_homeostasis0.96918504
121MP0009333_abnormal_splenocyte_physiolog0.95963126
122MP0004510_myositis0.92913717
123MP0002078_abnormal_glucose_homeostasis0.92427900
124MP0005167_abnormal_blood-brain_barrier0.91937987
125MP0003795_abnormal_bone_structure0.91599338
126MP0005390_skeleton_phenotype0.91008590
127MP0005164_abnormal_response_to0.89724208
128MP0005166_decreased_susceptibility_to0.88705972
129MP0003631_nervous_system_phenotype0.87780703
130MP0000716_abnormal_immune_system0.87443120
131MP0004130_abnormal_muscle_cell0.85537549
132MP0005448_abnormal_energy_balance0.85324094
133MP0004147_increased_porphyrin_level0.84878669
134MP0003303_peritoneal_inflammation0.84470924
135MP0002254_reproductive_system_inflammat0.83313469
136MP0001853_heart_inflammation0.82830626
137MP0001986_abnormal_taste_sensitivity0.81913745
138MP0001851_eye_inflammation0.81518125
139MP0008569_lethality_at_weaning0.81151965
140MP0010352_gastrointestinal_tract_polyps0.80143927
141MP0004883_abnormal_blood_vessel0.80001985
142MP0000490_abnormal_crypts_of0.78524904
143MP0003283_abnormal_digestive_organ0.78199841
144MP0005023_abnormal_wound_healing0.78145204
145MP0001486_abnormal_startle_reflex0.77602080
146MP0000465_gastrointestinal_hemorrhage0.75547660
147MP0005165_increased_susceptibility_to0.75037973
148MP0003634_abnormal_glial_cell0.74210952
149MP0002138_abnormal_hepatobiliary_system0.73911789
150MP0004924_abnormal_behavior0.72465096
151MP0005386_behavior/neurological_phenoty0.72465096
152MP0002928_abnormal_bile_duct0.71819695
153MP0002069_abnormal_eating/drinking_beha0.71813157
154MP0003953_abnormal_hormone_level0.70935244
155MP0002876_abnormal_thyroid_physiology0.69593679
156MP0000249_abnormal_blood_vessel0.69295776
157MP0000767_abnormal_smooth_muscle0.68248457
158MP0009642_abnormal_blood_homeostasis0.67868780
159MP0002557_abnormal_social/conspecific_i0.67243264
160MP0004264_abnormal_extraembryonic_tissu0.66976096
161MP0003638_abnormal_response/metabolism_0.66776256
162MP0003866_abnormal_defecation0.65656312
163MP0002090_abnormal_vision0.64598084
164MP0009764_decreased_sensitivity_to0.64244775
165MP0001270_distended_abdomen0.64147298
166MP0000955_abnormal_spinal_cord0.63850431
167MP0005334_abnormal_fat_pad0.61896922
168MP0005636_abnormal_mineral_homeostasis0.61228804

Predicted human phenotypes

RankGene SetZ-score
1Vacuolated lymphocytes (HP:0001922)4.44239246
2Abnormality of macrophages (HP:0004311)4.33541569
3Eczematoid dermatitis (HP:0000976)4.24270232
4Recurrent abscess formation (HP:0002722)3.78577131
5Abnormality of glutamine family amino acid metabolism (HP:0010902)3.77799946
6Recurrent bacterial skin infections (HP:0005406)3.73874860
7Increased neuronal autofluorescent lipopigment (HP:0002074)3.54446204
8Xanthomatosis (HP:0000991)3.50222930
9Abnormality of aromatic amino acid family metabolism (HP:0004338)3.49061217
10Myokymia (HP:0002411)3.47640236
11Deep venous thrombosis (HP:0002625)3.46118101
12Loss of speech (HP:0002371)3.44923759
13Disinhibition (HP:0000734)3.31093082
14Complement deficiency (HP:0004431)3.20018000
15Malnutrition (HP:0004395)3.17612355
16Action tremor (HP:0002345)3.17036675
17Abnormality of monocarboxylic acid metabolism (HP:0010996)3.08245722
18Neurofibrillary tangles (HP:0002185)3.08160838
19Intrahepatic cholestasis (HP:0001406)2.91783518
20Systemic lupus erythematosus (HP:0002725)2.90734499
21Conjugated hyperbilirubinemia (HP:0002908)2.88029277
22Focal seizures (HP:0007359)2.85375170
23Gingivitis (HP:0000230)2.84321177
24Spontaneous hematomas (HP:0007420)2.82077371
25Hypobetalipoproteinemia (HP:0003563)2.80909826
26Urinary glycosaminoglycan excretion (HP:0003541)2.78139943
27Mucopolysacchariduria (HP:0008155)2.78139943
28Abnormality of mucopolysaccharide metabolism (HP:0011020)2.77823440
29Abnormality of polysaccharide metabolism (HP:0011012)2.77823440
30Abnormality of glycosaminoglycan metabolism (HP:0004371)2.77823440
31Supranuclear gaze palsy (HP:0000605)2.73227640
32Focal motor seizures (HP:0011153)2.68838930
33Myocardial infarction (HP:0001658)2.65407692
34Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)2.62782332
35Abnormality of proline metabolism (HP:0010907)2.58095120
36Hydroxyprolinuria (HP:0003080)2.58095120
37Visual hallucinations (HP:0002367)2.57271008
38Ketosis (HP:0001946)2.53836261
39Dysostosis multiplex (HP:0000943)2.53130271
40Axonal loss (HP:0003447)2.49364397
41Ketoacidosis (HP:0001993)2.48243118
42Sensorimotor neuropathy (HP:0007141)2.48120430
43Epidermoid cyst (HP:0200040)2.46485309
44Orchitis (HP:0100796)2.46055907
45Joint hemorrhage (HP:0005261)2.45436463
46Myositis (HP:0100614)2.43020066
47Glomerulonephritis (HP:0000099)2.40176305
48Abnormality of the common coagulation pathway (HP:0010990)2.39739571
49Upper motor neuron abnormality (HP:0002127)2.37819709
50Prolonged partial thromboplastin time (HP:0003645)2.37102310
51Cerebral aneurysm (HP:0004944)2.35077874
52Gout (HP:0001997)2.33515934
53Abnormality of the vasculature of the conjunctiva (HP:0008054)2.33431459
54Apathy (HP:0000741)2.32654859
55Abnormality of the lower motor neuron (HP:0002366)2.31736138
56Mediastinal lymphadenopathy (HP:0100721)2.30223864
57Abnormality of complement system (HP:0005339)2.27754971
58Diminished motivation (HP:0000745)2.25100178
59Status epilepticus (HP:0002133)2.25093519
60Elevated circulating parathyroid hormone (PTH) level (HP:0003165)2.24398313
61Thin bony cortex (HP:0002753)2.22744391
62Increased cerebral lipofuscin (HP:0011813)2.22325333
63Abnormality of purine metabolism (HP:0004352)2.20502483
64Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)2.19600974
65Hypercholesterolemia (HP:0003124)2.18948017
66Recurrent skin infections (HP:0001581)2.18263419
67Generalized tonic-clonic seizures (HP:0002069)2.17042830
68Asymmetric septal hypertrophy (HP:0001670)2.14194539
69Vertebral compression fractures (HP:0002953)2.14144827
70Obstructive lung disease (HP:0006536)2.13670096
71Chronic obstructive pulmonary disease (HP:0006510)2.13670096
72Pathologic fracture (HP:0002756)2.13413242
73Febrile seizures (HP:0002373)2.13005286
74Abnormality of sulfur amino acid metabolism (HP:0004339)2.12773872
75Atonic seizures (HP:0010819)2.12143383
76Fat malabsorption (HP:0002630)2.12098830
77Postural instability (HP:0002172)2.11343395
78Bone pain (HP:0002653)2.11319091
79Skin nodule (HP:0200036)2.09875717
80Neuronal loss in central nervous system (HP:0002529)2.09393307
81Hyperammonemia (HP:0001987)2.09129644
82Absence seizures (HP:0002121)2.08225681
83Global brain atrophy (HP:0002283)2.07211642
84Insidious onset (HP:0003587)2.06641246
85Termporal pattern (HP:0011008)2.06641246
86Segmental peripheral demyelination/remyelination (HP:0003481)2.06345348
87Mitral stenosis (HP:0001718)2.05946372
88Autoimmune thrombocytopenia (HP:0001973)2.05575191
89Impaired social interactions (HP:0000735)2.05163164
90Abnormal social behavior (HP:0012433)2.05163164
91Hyperactive renin-angiotensin system (HP:0000841)2.04400611
92Hypolipoproteinemia (HP:0010981)2.03754728
93Pheochromocytoma (HP:0002666)2.03643300
94Nuclear cataract (HP:0100018)2.03642716
95Polycythemia (HP:0001901)2.02560944
96Hyperglycinuria (HP:0003108)2.01727875
97Postural tremor (HP:0002174)2.01624566
98Retinal atrophy (HP:0001105)2.01522293
99Hyperlipoproteinemia (HP:0010980)2.01505032
100Neonatal onset (HP:0003623)2.00555189
101Cellulitis (HP:0100658)1.99115891
102Hand muscle atrophy (HP:0009130)1.98913944
103Facial shape deformation (HP:0011334)1.96542325
104Potter facies (HP:0002009)1.96542325
105Hematochezia (HP:0002573)1.96448895
106Impaired pain sensation (HP:0007328)1.95507346
107Abnormality of pain sensation (HP:0010832)1.95507346
108Peripheral demyelination (HP:0011096)1.94856361
109Optic neuritis (HP:0100653)1.94577667
110Retrobulbar optic neuritis (HP:0100654)1.94577667
111Increased CSF protein (HP:0002922)1.93996777
112Papilledema (HP:0001085)1.93259445
113Progressive cerebellar ataxia (HP:0002073)1.92793950
114Metaphyseal irregularity (HP:0003025)1.92650009
115Dementia (HP:0000726)1.90878028
116Amyloidosis (HP:0011034)1.90725521
117Increased serum ferritin (HP:0003281)1.90253185
118Osteolytic defects of the hand bones (HP:0009699)1.89930756
119Osteolytic defects of the phalanges of the hand (HP:0009771)1.89930756
120Abnormality of nucleobase metabolism (HP:0010932)1.89589570
121Recurrent gram-negative bacterial infections (HP:0005420)1.89497597
122Ulnar claw (HP:0001178)1.88536463
123Hypercortisolism (HP:0001578)1.88534766
124Agitation (HP:0000713)1.88198794
125Dialeptic seizures (HP:0011146)1.87928816
126Purpura (HP:0000979)1.86577490
127Urinary bladder sphincter dysfunction (HP:0002839)1.85155255
128Torticollis (HP:0000473)1.84319224
129Cerebral inclusion bodies (HP:0100314)1.83812023
130Urticaria (HP:0001025)1.83650616
131Alkalosis (HP:0001948)1.81911094
132Progressive visual loss (HP:0000529)1.81719479
133Abnormality of calcium-phosphate metabolism (HP:0100530)1.81190445
134Peritonitis (HP:0002586)1.81090058
135Petechiae (HP:0000967)1.80880968
136Nephritis (HP:0000123)1.80378723
137Acanthocytosis (HP:0001927)1.80339255
138Personality changes (HP:0000751)1.80310117
139Hepatosplenomegaly (HP:0001433)1.79691928
140Mutism (HP:0002300)1.79669754
141Hyperparathyroidism (HP:0000843)1.79637896
142Recurrent fungal infections (HP:0002841)1.79635329
143Abnormality of aspartate family amino acid metabolism (HP:0010899)1.79530979
144Depression (HP:0000716)1.78873244
145Cardiomegaly (HP:0001640)1.76531454
146Progressive neurologic deterioration (HP:0002344)1.75252409
147Gastrointestinal infarctions (HP:0005244)1.75132688
148Tetraparesis (HP:0002273)1.75013491
149Protuberant abdomen (HP:0001538)1.74806780
150Inappropriate behavior (HP:0000719)1.73805157
151Hypoglycemic coma (HP:0001325)1.73780358
152Premature loss of primary teeth (HP:0006323)1.73415810
153Abnormality of serine family amino acid metabolism (HP:0010894)1.72958241
154Abnormality of glycine metabolism (HP:0010895)1.72958241
155Abnormal eating behavior (HP:0100738)1.71984743
156Abnormality of liposaccharide metabolism (HP:0010968)1.71953448
157Abnormality of glycosphingolipid metabolism (HP:0004343)1.71953448
158Abnormality of glycolipid metabolism (HP:0010969)1.71953448
159Abnormality of the level of lipoprotein cholesterol (HP:0010979)1.71739632
160Osteomyelitis (HP:0002754)1.70878808
161Distal upper limb amyotrophy (HP:0007149)1.70567354
162Pulmonary infiltrates (HP:0002113)1.69160699
163Agnosia (HP:0010524)1.68263543
164Hypophosphatemia (HP:0002148)1.68241412
165Hemorrhage of the eye (HP:0011885)1.67804403
166Flat acetabular roof (HP:0003180)1.66164909
167Pustule (HP:0200039)1.66011734
168Slow saccadic eye movements (HP:0000514)1.65412910
169Spondylolisthesis (HP:0003302)1.65259857
170Abnormality of iron homeostasis (HP:0011031)1.64290759
171Chronic diarrhea (HP:0002028)1.62955176
172Thoracic kyphosis (HP:0002942)1.62793723
173Abdominal distention (HP:0003270)1.62682697
174Hemoptysis (HP:0002105)1.61724608
175Aneurysm (HP:0002617)1.61423884

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAP3K93.13369242
2RIPK43.03478925
3NTRK12.91986511
4NTRK32.72193752
5BLK2.72075607
6KSR22.60732572
7MAP3K22.51312301
8IRAK32.40673879
9MAP2K32.38185713
10MAP3K32.17362360
11DAPK22.17024160
12MAP2K42.13566234
13ERN12.12482114
14MAP3K42.04540161
15ACVR1B2.03974058
16SIK21.96916691
17RIPK11.91518677
18DDR21.86368869
19GRK51.75800799
20MINK11.74471442
21CSK1.73215693
22LMTK21.72944353
23RET1.70379343
24MAP3K141.66959551
25CAMKK11.66914892
26FRK1.64975534
27MAP3K111.60604990
28SIK11.58576243
29TAOK31.58531642
30IRAK41.57920783
31FGR1.56068494
32TAOK21.55251644
33PAK61.50276697
34TRIB31.47992187
35ZAP701.47605127
36EPHA41.41155065
37SGK31.37351007
38MATK1.32542197
39CAMK1G1.32170047
40MAP2K71.28960177
41STK381.28639928
42MAP3K11.26980145
43PKN21.25531480
44TBK11.22177700
45MAP3K131.21383850
46FGFR41.17012627
47MAP4K11.15903808
48TESK21.14720126
49INSRR1.14496504
50MAP3K71.13693462
51SCYL21.11178173
52SGK21.10727801
53CDK121.08296634
54JAK11.05842126
55GRK61.05483597
56PRKD21.04365430
57PTK61.03145213
58SGK2231.01366204
59SGK4941.01366204
60CAMKK21.00417801
61TESK10.98016960
62CSF1R0.95542358
63PRKD30.95291248
64FES0.95095919
65JAK20.95071984
66ARAF0.94973048
67RPS6KA20.94581790
68JAK30.94562293
69MAP2K10.92430777
70PTK20.91697934
71CAMK1D0.91497658
72SMG10.90326469
73PRKCH0.89665588
74MAP3K120.86577661
75GRK70.86066495
76PAK40.85318613
77MAP3K60.84668790
78WNK10.84556925
79PDPK10.84382994
80CDK50.84257117
81DAPK10.83690441
82EPHB10.83201993
83ABL20.82842871
84PDK10.82394389
85TAOK10.82368862
86IRAK20.81907268
87NME20.81352234
88HCK0.77310139
89CDK60.75765379
90SYK0.74639501
91WNK40.72412148
92TTN0.72120343
93PRKG20.71380379
94FGFR30.69362007
95CAMK40.67583508
96KSR10.67548262
97SIK30.66940522
98YES10.66114092
99MAPK120.65641868
100MOS0.65593753
101LYN0.64088864
102ALK0.62684275
103NTRK20.61398430
104STK110.60909590
105ERBB20.60894799
106PRKCG0.60385724
107PDK20.59239945
108NEK90.59156395
109LATS20.59101885
110PRKCZ0.58408441
111IKBKE0.57684791
112PDGFRB0.56457762
113RPS6KL10.56419701
114RPS6KC10.56419701
115MST1R0.55113032
116TGFBR20.52548015
117MAP2K20.52252420
118PTK2B0.51730374
119MAP3K50.51374617
120MARK10.50869070
121PDGFRA0.50597833
122CDC42BPA0.48379288
123MAPK150.47553454
124CAMK10.46656780
125SGK10.46225431
126MAPK70.46100095
127MARK20.45906326
128MAP3K80.44452437
129HIPK20.44413918
130MAPK110.44072599
131PRPF4B0.43871370
132BTK0.43816491
133TYK20.43454206
134PRKAA10.43306770
135LCK0.43183467
136FYN0.43104679
137PRKACG0.41807162
138IKBKB0.41197020
139KIT0.41062389
140BMX0.40599055
141PINK10.39357487
142PRKAA20.39300934
143TNK20.38643814
144RAF10.38396015
145FER0.37766260
146RPS6KA60.36378257
147IRAK10.35541676
148SRC0.35453203
149BMPR20.35339934
150MARK30.35297718
151MAP2K60.33915844
152ICK0.32461515
153CAMK2A0.32279551
154CSNK1G20.32277136

Predicted pathways (KEGG)

RankGene SetZ-score
1Other glycan degradation_Homo sapiens_hsa005113.53007721
2Nitrogen metabolism_Homo sapiens_hsa009102.54483411
3Osteoclast differentiation_Homo sapiens_hsa043802.23566672
4Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049642.23273553
5Arginine biosynthesis_Homo sapiens_hsa002202.10991029
6Leishmaniasis_Homo sapiens_hsa051402.10623906
7Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004002.06831377
8Primary bile acid biosynthesis_Homo sapiens_hsa001202.02230815
9Bile secretion_Homo sapiens_hsa049761.98534850
10Tuberculosis_Homo sapiens_hsa051521.90113932
11Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.87588928
12Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.78999992
13Synaptic vesicle cycle_Homo sapiens_hsa047211.67846014
14Tryptophan metabolism_Homo sapiens_hsa003801.64346787
15Toll-like receptor signaling pathway_Homo sapiens_hsa046201.63378532
16Phagosome_Homo sapiens_hsa041451.52904187
17Malaria_Homo sapiens_hsa051441.50348340
18Carbohydrate digestion and absorption_Homo sapiens_hsa049731.48738894
19Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.45377992
20Complement and coagulation cascades_Homo sapiens_hsa046101.36729670
21Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.35943065
22Starch and sucrose metabolism_Homo sapiens_hsa005001.35673398
23Rheumatoid arthritis_Homo sapiens_hsa053231.33554874
24Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.32435128
25Toxoplasmosis_Homo sapiens_hsa051451.31966439
26Type II diabetes mellitus_Homo sapiens_hsa049301.31741352
27Fat digestion and absorption_Homo sapiens_hsa049751.30998892
28B cell receptor signaling pathway_Homo sapiens_hsa046621.30319584
29Butanoate metabolism_Homo sapiens_hsa006501.29124208
30Pertussis_Homo sapiens_hsa051331.29115340
31Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.26386300
32Insulin secretion_Homo sapiens_hsa049111.23966838
33Pentose and glucuronate interconversions_Homo sapiens_hsa000401.22197033
34Staphylococcus aureus infection_Homo sapiens_hsa051501.20408872
35Caffeine metabolism_Homo sapiens_hsa002321.17692337
36Fatty acid degradation_Homo sapiens_hsa000711.17338750
37Histidine metabolism_Homo sapiens_hsa003401.16956488
38Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.16885753
39TNF signaling pathway_Homo sapiens_hsa046681.14917032
40Acute myeloid leukemia_Homo sapiens_hsa052211.14839437
41Mineral absorption_Homo sapiens_hsa049781.14437304
42Salmonella infection_Homo sapiens_hsa051321.14412507
43Amoebiasis_Homo sapiens_hsa051461.11968190
44PPAR signaling pathway_Homo sapiens_hsa033201.11663360
45ABC transporters_Homo sapiens_hsa020101.07898300
46Salivary secretion_Homo sapiens_hsa049701.05642981
47Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051201.01580272
48Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.01277238
49Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.01086811
50Allograft rejection_Homo sapiens_hsa053301.00735095
51Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.00539385
52Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.99517862
53Maturity onset diabetes of the young_Homo sapiens_hsa049500.99413885
54Influenza A_Homo sapiens_hsa051640.98152920
55Chemokine signaling pathway_Homo sapiens_hsa040620.98124427
56Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.97122210
57Leukocyte transendothelial migration_Homo sapiens_hsa046700.95660365
58Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.95240743
59Long-term potentiation_Homo sapiens_hsa047200.95068524
60AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.94027654
61NOD-like receptor signaling pathway_Homo sapiens_hsa046210.93874727
62Circadian entrainment_Homo sapiens_hsa047130.93480750
63Chronic myeloid leukemia_Homo sapiens_hsa052200.93440819
64Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.93158873
65NF-kappa B signaling pathway_Homo sapiens_hsa040640.91772338
66Legionellosis_Homo sapiens_hsa051340.91331435
67Antigen processing and presentation_Homo sapiens_hsa046120.91141552
68Asthma_Homo sapiens_hsa053100.90750166
69Graft-versus-host disease_Homo sapiens_hsa053320.90725985
70Phenylalanine metabolism_Homo sapiens_hsa003600.90402594
71Glycosaminoglycan degradation_Homo sapiens_hsa005310.89649794
72Gastric acid secretion_Homo sapiens_hsa049710.89550597
73Cholinergic synapse_Homo sapiens_hsa047250.89443161
74Renin-angiotensin system_Homo sapiens_hsa046140.89331844
75Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.89096969
76Olfactory transduction_Homo sapiens_hsa047400.88433061
77Hepatitis C_Homo sapiens_hsa051600.88360882
78Bladder cancer_Homo sapiens_hsa052190.88272909
79Aldosterone synthesis and secretion_Homo sapiens_hsa049250.86912710
80Glutamatergic synapse_Homo sapiens_hsa047240.86612417
81Glycerolipid metabolism_Homo sapiens_hsa005610.86055766
82Renal cell carcinoma_Homo sapiens_hsa052110.85649569
83Pancreatic cancer_Homo sapiens_hsa052120.84944217
84Vibrio cholerae infection_Homo sapiens_hsa051100.84779820
85Sulfur metabolism_Homo sapiens_hsa009200.83567356
86Collecting duct acid secretion_Homo sapiens_hsa049660.83498734
87GABAergic synapse_Homo sapiens_hsa047270.83386020
88Sphingolipid metabolism_Homo sapiens_hsa006000.83278841
89GnRH signaling pathway_Homo sapiens_hsa049120.83076508
90Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.82871977
91Dopaminergic synapse_Homo sapiens_hsa047280.82286982
92Nicotine addiction_Homo sapiens_hsa050330.81898902
93VEGF signaling pathway_Homo sapiens_hsa043700.80817465
94Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.80643957
95Hepatitis B_Homo sapiens_hsa051610.80237061
96Amphetamine addiction_Homo sapiens_hsa050310.79969381
97Autoimmune thyroid disease_Homo sapiens_hsa053200.79722862
98Non-small cell lung cancer_Homo sapiens_hsa052230.79609658
99Phosphatidylinositol signaling system_Homo sapiens_hsa040700.79267006
100Thyroid hormone synthesis_Homo sapiens_hsa049180.78826368
101Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.78783938
102Vitamin digestion and absorption_Homo sapiens_hsa049770.78765424
103Sphingolipid signaling pathway_Homo sapiens_hsa040710.78131331
104Fatty acid metabolism_Homo sapiens_hsa012120.76411366
105Peroxisome_Homo sapiens_hsa041460.76332480
106Adipocytokine signaling pathway_Homo sapiens_hsa049200.76262387
107Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.76125147
108Hematopoietic cell lineage_Homo sapiens_hsa046400.75670242
109Shigellosis_Homo sapiens_hsa051310.74968167
110Lysosome_Homo sapiens_hsa041420.74854726
111Endocytosis_Homo sapiens_hsa041440.73924217
112Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.73567712
113Cyanoamino acid metabolism_Homo sapiens_hsa004600.73536570
114* Protein digestion and absorption_Homo sapiens_hsa049740.73447426
115beta-Alanine metabolism_Homo sapiens_hsa004100.72891103
116Renin secretion_Homo sapiens_hsa049240.72025984
117Viral myocarditis_Homo sapiens_hsa054160.70787072
118Dorso-ventral axis formation_Homo sapiens_hsa043200.70777690
119Apoptosis_Homo sapiens_hsa042100.70758305
120Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.70130855
121African trypanosomiasis_Homo sapiens_hsa051430.70127610
122Platelet activation_Homo sapiens_hsa046110.69505328
123Prolactin signaling pathway_Homo sapiens_hsa049170.69098808
124Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.68716356
125Morphine addiction_Homo sapiens_hsa050320.68630397
1262-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.67992746
127Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.66601372
128Cocaine addiction_Homo sapiens_hsa050300.66040558
129Estrogen signaling pathway_Homo sapiens_hsa049150.65901628
130Taste transduction_Homo sapiens_hsa047420.65862751
131Insulin resistance_Homo sapiens_hsa049310.65497131
132Galactose metabolism_Homo sapiens_hsa000520.64714034
133Long-term depression_Homo sapiens_hsa047300.64351969
134Pancreatic secretion_Homo sapiens_hsa049720.62966808
135HIF-1 signaling pathway_Homo sapiens_hsa040660.60970232
136Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.60688291
137Glioma_Homo sapiens_hsa052140.60596608
138Tyrosine metabolism_Homo sapiens_hsa003500.59278847
139Lysine degradation_Homo sapiens_hsa003100.58685190
140Prion diseases_Homo sapiens_hsa050200.57258606
141Pyruvate metabolism_Homo sapiens_hsa006200.56654513
142Intestinal immune network for IgA production_Homo sapiens_hsa046720.54767131
143Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.54597285
144Measles_Homo sapiens_hsa051620.53866918
145T cell receptor signaling pathway_Homo sapiens_hsa046600.53341620
146Endometrial cancer_Homo sapiens_hsa052130.52886760
147RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.52795000
148Type I diabetes mellitus_Homo sapiens_hsa049400.52413500
149Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.51729935
150Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.51552619
151Choline metabolism in cancer_Homo sapiens_hsa052310.51421807
152Notch signaling pathway_Homo sapiens_hsa043300.50615332
153Insulin signaling pathway_Homo sapiens_hsa049100.50202387
154Propanoate metabolism_Homo sapiens_hsa006400.49668656
155Serotonergic synapse_Homo sapiens_hsa047260.48591459
156Neurotrophin signaling pathway_Homo sapiens_hsa047220.48578379
157Glucagon signaling pathway_Homo sapiens_hsa049220.48015994
158Proteoglycans in cancer_Homo sapiens_hsa052050.47887926
159Steroid hormone biosynthesis_Homo sapiens_hsa001400.47407095
160Jak-STAT signaling pathway_Homo sapiens_hsa046300.46431413
161Phospholipase D signaling pathway_Homo sapiens_hsa040720.45614953
162Inositol phosphate metabolism_Homo sapiens_hsa005620.45585014
163Fructose and mannose metabolism_Homo sapiens_hsa000510.43716745
164Chemical carcinogenesis_Homo sapiens_hsa052040.43370786
165Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.42641619
166Oxytocin signaling pathway_Homo sapiens_hsa049210.42274479
167mTOR signaling pathway_Homo sapiens_hsa041500.42258780
168Glycerophospholipid metabolism_Homo sapiens_hsa005640.41550393

Most similar genes based on co-expression Upload to Enrichr

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