SLC36A3

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1binding of sperm to zona pellucida (GO:0007339)9.84381941
2reproduction (GO:0000003)9.46564657
3axonemal dynein complex assembly (GO:0070286)9.05404117
4spermatid development (GO:0007286)9.03972357
5epithelial cilium movement (GO:0003351)9.02340244
6motile cilium assembly (GO:0044458)8.98951872
7cilium or flagellum-dependent cell motility (GO:0001539)8.74182100
8negative regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043371)8.10975961
9negative regulation of T-helper cell differentiation (GO:0045623)8.10975961
10positive regulation of protein sumoylation (GO:0033235)7.84344010
11regulation of cilium movement (GO:0003352)7.72393828
12cilium movement (GO:0003341)7.14707765
13single fertilization (GO:0007338)7.13585336
14detection of chemical stimulus involved in sensory perception (GO:0050907)7.02227423
15regulation of T-helper 1 cell differentiation (GO:0045625)6.94733988
16sperm capacitation (GO:0048240)6.81057024
17epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)6.63291257
18negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)6.56958957
19activation of protein kinase A activity (GO:0034199)6.56198914
20positive regulation of RNA splicing (GO:0033120)6.49760616
21negative regulation of inclusion body assembly (GO:0090084)6.48877187
22synaptonemal complex organization (GO:0070193)6.47192993
23regulation of T-helper 2 cell differentiation (GO:0045628)6.44195773
24negative regulation of alpha-beta T cell differentiation (GO:0046639)6.37633809
25synaptonemal complex assembly (GO:0007130)6.35177493
26positive regulation of mitochondrial fission (GO:0090141)6.26555118
27negative regulation of type 2 immune response (GO:0002829)6.24776833
28male meiosis (GO:0007140)6.20721015
29piRNA metabolic process (GO:0034587)6.17908916
30spermatogenesis (GO:0007283)6.15459532
31dendritic spine morphogenesis (GO:0060997)6.15238236
32cAMP biosynthetic process (GO:0006171)6.14203269
33male gamete generation (GO:0048232)6.13147603
34organic cation transport (GO:0015695)5.93901545
35microtubule depolymerization (GO:0007019)5.91559868
36fertilization (GO:0009566)5.90313313
37enteric nervous system development (GO:0048484)5.84158852
38spermatid nucleus differentiation (GO:0007289)5.80149295
39righting reflex (GO:0060013)5.67273527
40gamete generation (GO:0007276)5.62117605
41synaptic transmission, dopaminergic (GO:0001963)5.50257256
42regulation of inclusion body assembly (GO:0090083)5.43048550
43phosphatidylinositol acyl-chain remodeling (GO:0036149)5.24443142
44positive regulation of T-helper 1 type immune response (GO:0002827)5.11766448
45detection of chemical stimulus (GO:0009593)5.09775227
46cellular process involved in reproduction in multicellular organism (GO:0022412)4.97822694
47neural tube formation (GO:0001841)4.94886829
48calcium ion-dependent exocytosis (GO:0017156)4.94584302
49germ cell development (GO:0007281)4.86828996
50regulation of protein sumoylation (GO:0033233)4.83496300
51nephron tubule morphogenesis (GO:0072078)4.80254461
52nephron epithelium morphogenesis (GO:0072088)4.80254461
53phosphatidylserine acyl-chain remodeling (GO:0036150)4.71056773
54cell recognition (GO:0008037)4.70461902
55chromosome condensation (GO:0030261)4.67832957
56regulation of mitochondrial fission (GO:0090140)4.65156079
57sequestering of actin monomers (GO:0042989)4.63778940
58icosanoid secretion (GO:0032309)4.60575063
59arachidonic acid secretion (GO:0050482)4.60575063
60glycerol ether metabolic process (GO:0006662)4.48662497
61DNA packaging (GO:0006323)4.47163169
62phosphatidylglycerol acyl-chain remodeling (GO:0036148)4.42083950
63ventricular system development (GO:0021591)4.41524484
64multicellular organismal reproductive process (GO:0048609)4.38456409
65regulation of microtubule-based movement (GO:0060632)4.37555134
66negative regulation of cytosolic calcium ion concentration (GO:0051481)4.37020791
67chromosome organization involved in meiosis (GO:0070192)4.24086985
68drug transmembrane transport (GO:0006855)4.20417274
69hepatocyte apoptotic process (GO:0097284)4.20284016
70positive regulation of T-helper cell differentiation (GO:0045624)4.16593535
71single strand break repair (GO:0000012)4.15156272
72microtubule severing (GO:0051013)4.12456916
73ether metabolic process (GO:0018904)4.12360009
74heterotypic cell-cell adhesion (GO:0034113)4.11595785
75cellular response to ATP (GO:0071318)4.11482631
76male meiosis I (GO:0007141)4.07457038
77chemosensory behavior (GO:0007635)4.07033477
78energy coupled proton transmembrane transport, against electrochemical gradient (GO:0015988)4.05570656
79ATP hydrolysis coupled proton transport (GO:0015991)4.05570656
80protein localization to synapse (GO:0035418)4.00801171
81interferon-gamma secretion (GO:0072643)3.96462871
82sexual reproduction (GO:0019953)3.93053303
83DNA methylation involved in gamete generation (GO:0043046)3.85338571
84retina layer formation (GO:0010842)3.80518246
85neuronal ion channel clustering (GO:0045161)3.79456344
86endothelial cell differentiation (GO:0045446)3.79421394
87meiotic nuclear division (GO:0007126)3.77249726
88reflex (GO:0060004)3.77207957
89regulation of cAMP-mediated signaling (GO:0043949)3.74755008
90response to pheromone (GO:0019236)3.74269434
91regulation of T-helper 1 type immune response (GO:0002825)3.74139106
92chaperone-mediated protein complex assembly (GO:0051131)3.71938387
93seminiferous tubule development (GO:0072520)3.70698918
94icosanoid transport (GO:0071715)3.69213081
95fatty acid derivative transport (GO:1901571)3.69213081
96detection of light stimulus involved in sensory perception (GO:0050962)3.67467880
97detection of light stimulus involved in visual perception (GO:0050908)3.67467880
98positive regulation of membrane potential (GO:0045838)3.65218102
99negative regulation of alpha-beta T cell activation (GO:0046636)3.62989002
100phosphatidylethanolamine acyl-chain remodeling (GO:0036152)3.62914433
101cAMP metabolic process (GO:0046058)3.62561043
102vocalization behavior (GO:0071625)3.62327819
103embryonic digestive tract morphogenesis (GO:0048557)3.54104082
104left/right pattern formation (GO:0060972)3.50823284
105renal tubule morphogenesis (GO:0061333)3.47111449
106multicellular organismal development (GO:0007275)3.45398737
107left/right axis specification (GO:0070986)3.42846406
108monoubiquitinated protein deubiquitination (GO:0035520)3.30383777
109regulation of podosome assembly (GO:0071801)3.29634511
110exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 3.29260162
111monoamine transport (GO:0015844)3.28826777
112meiosis I (GO:0007127)3.28373588
113negative regulation of T cell differentiation (GO:0045581)3.24344542
114dendritic spine organization (GO:0097061)3.24133071
115negative regulation of astrocyte differentiation (GO:0048712)3.22721082
116regulation of dopamine uptake involved in synaptic transmission (GO:0051584)3.19237238
117regulation of catecholamine uptake involved in synaptic transmission (GO:0051940)3.19237238
118neurofilament cytoskeleton organization (GO:0060052)3.18785124
119nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)3.17230529
120regulation of T-helper cell differentiation (GO:0045622)3.15905923
121protein K11-linked deubiquitination (GO:0035871)3.15657503
122hindbrain development (GO:0030902)3.09474415
123positive regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043372)3.08693774
124behavioral response to nicotine (GO:0035095)3.08561089
125phosphatidylcholine acyl-chain remodeling (GO:0036151)3.08349908
126nucleus organization (GO:0006997)3.06578539
127cellular potassium ion transport (GO:0071804)3.04800721
128potassium ion transmembrane transport (GO:0071805)3.04800721
129attachment of spindle microtubules to kinetochore (GO:0008608)3.02679541
130cyclic nucleotide biosynthetic process (GO:0009190)3.02204520
131meiotic cell cycle (GO:0051321)3.01316815
132response to dietary excess (GO:0002021)3.00945261
133cyclic purine nucleotide metabolic process (GO:0052652)2.98258254
134RNA destabilization (GO:0050779)2.98230121
135microtubule polymerization or depolymerization (GO:0031109)2.96327109
136positive regulation of excitatory postsynaptic membrane potential (GO:2000463)2.93669091
137cellular ketone body metabolic process (GO:0046950)2.91504084
138regulation of neurotransmitter uptake (GO:0051580)2.90853160
139protein refolding (GO:0042026)2.89731853
140regulation of spindle checkpoint (GO:0090231)2.89443574
141genitalia morphogenesis (GO:0035112)2.87110204
142adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway (GO:0007193)2.87104595
143positive regulation of macrophage activation (GO:0043032)2.84062781
144nucleoside diphosphate phosphorylation (GO:0006165)2.81634173
145water transport (GO:0006833)2.81602476
146polyol catabolic process (GO:0046174)2.80383322
147positive regulation of protein targeting to membrane (GO:0090314)2.79798321
148leukotriene biosynthetic process (GO:0019370)2.77808367
149drug transport (GO:0015893)2.77565772
150positive regulation of extrinsic apoptotic signaling pathway via death domain receptors (GO:1902043)2.76655867
151positive regulation of CD4-positive, alpha-beta T cell activation (GO:2000516)2.76284605
152positive regulation of steroid hormone secretion (GO:2000833)2.76110487
153alditol metabolic process (GO:0019400)2.70668542
154centriole assembly (GO:0098534)2.68316726
155protein polyglutamylation (GO:0018095)2.66628207
156protein localization to cilium (GO:0061512)2.58523013
157glycolytic process (GO:0006096)2.52769524
158carnitine transport (GO:0015879)2.51513340
159amino-acid betaine transport (GO:0015838)2.51513340
160membrane protein intracellular domain proteolysis (GO:0031293)2.50228198
161meiotic cell cycle process (GO:1903046)2.47965149
162GTP biosynthetic process (GO:0006183)2.42035624
163single-organism membrane fusion (GO:0044801)2.41903575
164cellular response to arsenic-containing substance (GO:0071243)2.40150225
165centriole replication (GO:0007099)2.39831109
166natural killer cell mediated cytotoxicity (GO:0042267)2.37705990
167natural killer cell mediated immunity (GO:0002228)2.37705990
168cilium organization (GO:0044782)2.36300489
169RNA localization (GO:0006403)2.35324752
170mitotic sister chromatid cohesion (GO:0007064)2.35059232
171polyamine biosynthetic process (GO:0006596)2.33918507
172regulation of cilium assembly (GO:1902017)2.32855444
173carnitine transmembrane transport (GO:1902603)2.32541297
174synapsis (GO:0007129)2.29858990
175negative regulation of skeletal muscle tissue development (GO:0048642)2.28569304
176cilium assembly (GO:0042384)2.28312130
177mitochondrion degradation (GO:0000422)2.28191487
178microtubule-based movement (GO:0007018)2.27023290
179chromatin silencing (GO:0006342)2.26646364
180cell wall macromolecule catabolic process (GO:0016998)14.0769218
181cell wall macromolecule metabolic process (GO:0044036)14.0769218
182fusion of sperm to egg plasma membrane (GO:0007342)13.7018891
183sperm motility (GO:0030317)12.8589076
184sperm-egg recognition (GO:0035036)11.2233535
185acrosome reaction (GO:0007340)11.2021367
186multicellular organism reproduction (GO:0032504)11.0471075
187acrosome assembly (GO:0001675)10.8283055
188detection of chemical stimulus involved in sensory perception of smell (GO:0050911)10.8013565
189plasma membrane fusion (GO:0045026)10.3578943
190tooth mineralization (GO:0034505)10.1468748
191cell-cell recognition (GO:0009988)10.1425322

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse9.67745574
2HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse6.67832665
3IGF1R_20145208_ChIP-Seq_DFB_Human4.35206310
4TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse3.54141045
5TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat3.47875301
6BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse3.33183870
7AR_21572438_ChIP-Seq_LNCaP_Human3.32767963
8CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.67965198
9IRF8_21731497_ChIP-ChIP_J774_Mouse2.46846618
10STAT6_21828071_ChIP-Seq_BEAS2B_Human2.42507970
11GBX2_23144817_ChIP-Seq_PC3_Human2.36586662
12ZFP57_27257070_Chip-Seq_ESCs_Mouse2.24725456
13CREM_20920259_ChIP-Seq_GC1-SPG_Mouse2.21402570
14EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human2.20703154
15POU5F1_26923725_Chip-Seq_MESODERM_Mouse2.20527614
16TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.20527614
17CTBP1_25329375_ChIP-Seq_LNCAP_Human2.19815844
18GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.12199294
19VDR_22108803_ChIP-Seq_LS180_Human2.03386062
20PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse2.02085082
21PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human2.01487119
22GATA1_26923725_Chip-Seq_HPCs_Mouse1.93977560
23ER_23166858_ChIP-Seq_MCF-7_Human1.90805379
24CTBP2_25329375_ChIP-Seq_LNCAP_Human1.89205719
25PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.88950731
26FLI1_27457419_Chip-Seq_LIVER_Mouse1.83880974
27EZH2_22144423_ChIP-Seq_EOC_Human1.81818125
28FLI1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.78186256
29KAP1_22055183_ChIP-Seq_ESCs_Mouse1.75706222
30STAT1_17558387_ChIP-Seq_HELA_Human1.72983771
31* IRF8_27001747_Chip-Seq_BMDM_Mouse1.71943011
32SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.70531256
33* AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.69379519
34TP53_16413492_ChIP-PET_HCT116_Human1.62719100
35SMAD3_21741376_ChIP-Seq_EPCs_Human1.62124062
36UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.62091740
37ELK4_26923725_Chip-Seq_MESODERM_Mouse1.61667800
38GATA3_21867929_ChIP-Seq_CD8_Mouse1.60262424
39TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse1.60022788
40SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.57338916
41PCGF2_27294783_Chip-Seq_ESCs_Mouse1.54454999
42* KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.53982363
43* GATA2_21186366_ChIP-Seq_BM-HSCs_Mouse1.52055138
44DROSHA_22980978_ChIP-Seq_HELA_Human1.51135565
45SOX2_22085726_ChIP-Seq_NPCs_Mouse1.49286465
46STAT3_23295773_ChIP-Seq_U87_Human1.49222607
47BCAT_22108803_ChIP-Seq_LS180_Human1.48517782
48P300_19829295_ChIP-Seq_ESCs_Human1.47060956
49* RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.46014694
50SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.44958474
51RNF2_27304074_Chip-Seq_NSC_Mouse1.44932223
52WDR5_24793694_ChIP-Seq_LNCAP_Human1.43481511
53PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse1.43396127
54REST_21632747_ChIP-Seq_MESCs_Mouse1.43256227
55NANOG_18555785_Chip-Seq_ESCs_Mouse1.42436225
56ZNF274_21170338_ChIP-Seq_K562_Hela1.41526293
57KDM2B_26808549_Chip-Seq_REH_Human1.39334220
58FUS_26573619_Chip-Seq_HEK293_Human1.39019861
59* LUZP1_20508642_ChIP-Seq_ESCs_Mouse1.38880787
60EGR1_23403033_ChIP-Seq_LIVER_Mouse1.38667810
61GATA3_21867929_ChIP-Seq_TH1_Mouse1.38134200
62MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.37424263
63FLI1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.37417108
64PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse1.36950519
65SMAD4_21799915_ChIP-Seq_A2780_Human1.36451824
66AR_25329375_ChIP-Seq_VCAP_Human1.36136308
67BMI1_23680149_ChIP-Seq_NPCS_Mouse1.35826180
68PRDM14_20953172_ChIP-Seq_ESCs_Human1.35160669
69EGR1_19374776_ChIP-ChIP_THP-1_Human1.33889715
70ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.31984098
71TAL1_26923725_Chip-Seq_HPCs_Mouse1.31510230
72EZH2_27304074_Chip-Seq_ESCs_Mouse1.30766988
73MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.30744224
74* LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.30441863
75Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.29436888
76* CEBPB_26923725_Chip-Seq_MACROPHAGESS_Mouse1.29172588
77P53_21459846_ChIP-Seq_SAOS-2_Human1.27577130
78CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.26568716
79EZH2_27294783_Chip-Seq_NPCs_Mouse1.26350163
80MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.25942654
81SMAD4_21741376_ChIP-Seq_EPCs_Human1.25649339
82TCF4_22108803_ChIP-Seq_LS180_Human1.25473426
83* SPI1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.25282240
84POU3F2_20337985_ChIP-ChIP_501MEL_Human1.25128380
85TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.24122155
86GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.23670022
87ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.23641401
88SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.21690128
89CBP_20019798_ChIP-Seq_JUKART_Human1.21547964
90IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.21547964
91RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.21348760
92PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.20402635
93* PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.19748067
94JARID2_20064375_ChIP-Seq_MESCs_Mouse1.18704628
95SMAD3_21741376_ChIP-Seq_HESCs_Human1.18537199
96RNF2_27304074_Chip-Seq_ESCs_Mouse1.17881760
97BCOR_27268052_Chip-Seq_Bcells_Human1.17091372
98PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.15994122
99STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.15637638
100* SPI1_26923725_Chip-Seq_HPCs_Mouse1.15568525
101EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.15381422
102TCF12/HEB_22897851_ChIP-Seq_JUKARTE6-1_Human1.15303787
103SOX2_19829295_ChIP-Seq_ESCs_Human1.14264077
104NANOG_19829295_ChIP-Seq_ESCs_Human1.14264077
105NR3C1_23031785_ChIP-Seq_PC12_Mouse1.13927973
106FOXA1_27270436_Chip-Seq_PROSTATE_Human1.13787412
107FOXA1_25329375_ChIP-Seq_VCAP_Human1.13787412
108NANOG_20526341_ChIP-Seq_ESCs_Human1.13428981
109RXR_22108803_ChIP-Seq_LS180_Human1.13421612
110EZH2_27294783_Chip-Seq_ESCs_Mouse1.12492602
111BRD4_27068464_Chip-Seq_AML-cells_Mouse1.12212141
112P53_22387025_ChIP-Seq_ESCs_Mouse1.10622942
113TBL1_22424771_ChIP-Seq_293T_Human1.10262451
114SIN3B_21632747_ChIP-Seq_MESCs_Mouse1.10162592
115FLI1_21867929_ChIP-Seq_TH2_Mouse1.10045878
116RAD21_21589869_ChIP-Seq_MESCs_Mouse1.09470423
117SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.09208573
118JARID2_20075857_ChIP-Seq_MESCs_Mouse1.08784516
119MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.08241342
120SOX2_18555785_Chip-Seq_ESCs_Mouse1.08032084
121HNFA_21074721_ChIP-Seq_CACO-2_Human1.07923694
122ELF1_20517297_ChIP-Seq_JURKAT_Human1.07840487
123ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.07819259
124SUZ12_18555785_Chip-Seq_ESCs_Mouse1.07713722
125TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human1.07573699
126KLF1_20508144_ChIP-Seq_FETAL-LIVER-ERYTHROID_Mouse1.07427060
127NFE2_27457419_Chip-Seq_LIVER_Mouse1.07193430
128MYB_26560356_Chip-Seq_TH2_Human1.06877871
129ARNT_22903824_ChIP-Seq_MCF-7_Human1.06735441
130CMYC_18555785_Chip-Seq_ESCs_Mouse1.06613595
131EED_16625203_ChIP-ChIP_MESCs_Mouse1.06549653
132E2F1_18555785_Chip-Seq_ESCs_Mouse1.06380155
133MYB_21317192_ChIP-Seq_ERMYB_Mouse1.06317586
134PHF8_20622853_ChIP-Seq_HELA_Human1.06082691
135TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.05494665
136GATA6_21074721_ChIP-Seq_CACO-2_Human1.05473472
137PCGF2_27294783_Chip-Seq_NPCs_Mouse1.05406214
138CRX_20693478_ChIP-Seq_RETINA_Mouse1.05220794
139KLF5_20875108_ChIP-Seq_MESCs_Mouse1.05129100
140GATA1_19941827_ChIP-Seq_MEL86_Mouse1.05052162
141TOP2B_26459242_ChIP-Seq_MCF-7_Human1.05022913
142STAT3_18555785_Chip-Seq_ESCs_Mouse1.04895493
143RARA_24833708_ChIP-Seq_LIVER_Mouse1.04347974
144GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.04291283
145* ETV2_25802403_ChIP-Seq_MESCs_Mouse1.03779809
146SUZ12_27294783_Chip-Seq_ESCs_Mouse1.03771770
147TET1_21451524_ChIP-Seq_MESCs_Mouse1.03457903
148REST_18959480_ChIP-ChIP_MESCs_Mouse1.03112227
149RBPJ_21746931_ChIP-Seq_IB4-LCL_Human1.02731998
150SETDB1_19884257_ChIP-Seq_MESCs_Mouse1.02677632
151EWS_26573619_Chip-Seq_HEK293_Human1.02153566
152ESET_19884257_ChIP-Seq_ESCs_Mouse1.01649586
153GF1_26923725_Chip-Seq_HPCs_Mouse1.01593497
154ERG_20517297_ChIP-Seq_VCAP_Human1.01144602
155SMAD4_21741376_ChIP-Seq_HESCs_Human1.00748364
156BCL6_27268052_Chip-Seq_Bcells_Human1.00726754
157SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.00404430
158* EBNA1_20929547_Chip-Seq_RAJI-cells_Human1.00283366
159ETV1_20927104_ChIP-Seq_GIST48_Human1.00221700
160TCF4_23295773_ChIP-Seq_U87_Human0.99411638
161CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse0.99202317
162YY1_22570637_ChIP-Seq_MALME-3M_Human0.99090928
163PCGF4_22325352_ChIP-Seq_293T-Rex_Human0.98860354
164RXRA_24833708_ChIP-Seq_LIVER_Mouse0.98776937
165JARID1B-DAIN_22020125_ChIP-Seq_ESCs_Mouse0.98643528
166LDB1_21186366_ChIP-Seq_BM-HSCs_Mouse0.96983459
167PBX1_22567123_ChIP-ChIP_OVCAR3_Human0.96946202
168FLI1_21867929_ChIP-Seq_CD8_Mouse0.95552371
169CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse0.95547119
170CBX2_27304074_Chip-Seq_ESCs_Mouse0.95169136
171PHF8_20622854_ChIP-Seq_HELA_Human0.94462875
172TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.94322146
173NFIB_24661679_ChIP-Seq_LUNG_Mouse0.93673239
174SUZ12_27294783_Chip-Seq_NPCs_Mouse0.93403957
175CTCF_26484167_Chip-Seq_Bcells_Mouse0.92497802
176* CEBPB_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.92364625
177IRF8_22096565_ChIP-ChIP_GC-B_Human0.92358172
178TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse0.92357912
179VDR_24787735_ChIP-Seq_THP-1_Human0.91809827
180* CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse0.91666244
181EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human0.91041594

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005084_abnormal_gallbladder_morpholo9.16130404
2MP0008961_abnormal_basal_metabolism6.58858101
3MP0003698_abnormal_male_reproductive5.24917017
4MP0001929_abnormal_gametogenesis4.86831522
5MP0004130_abnormal_muscle_cell3.30064100
6MP0008877_abnormal_DNA_methylation3.25324146
7MP0006072_abnormal_retinal_apoptosis3.00500666
8MP0004133_heterotaxia2.89414197
9MP0002210_abnormal_sex_determination2.87276240
10MP0002161_abnormal_fertility/fecundity2.83157255
11MP0003252_abnormal_bile_duct2.76445241
12MP0001835_abnormal_antigen_presentation2.50834374
13MP0001145_abnormal_male_reproductive2.42231395
14MP0005670_abnormal_white_adipose2.38448215
15MP0003436_decreased_susceptibility_to2.05452027
16MP0000653_abnormal_sex_gland2.03691826
17MP0005410_abnormal_fertilization15.0307919
18MP0005551_abnormal_eye_electrophysiolog1.98410271
19MP0004264_abnormal_extraembryonic_tissu1.97337279
20MP0005448_abnormal_energy_balance1.88794213
21MP0002751_abnormal_autonomic_nervous1.88504639
22MP0005379_endocrine/exocrine_gland_phen1.87694503
23MP0003195_calcinosis1.74275250
24MP0005646_abnormal_pituitary_gland1.74220623
25MP0009278_abnormal_bone_marrow1.71724364
26MP0008875_abnormal_xenobiotic_pharmacok1.68667096
27MP0002653_abnormal_ependyma_morphology1.67081928
28MP0003718_maternal_effect1.64176271
29MP0001529_abnormal_vocalization1.64171870
30MP0005253_abnormal_eye_physiology1.62512277
31MP0005408_hypopigmentation1.59452888
32MP0002572_abnormal_emotion/affect_behav1.59142137
33MP0001968_abnormal_touch/_nociception1.59087498
34MP0000685_abnormal_immune_system1.59046517
35MP0001270_distended_abdomen1.57951701
36MP0009785_altered_susceptibility_to1.51458800
37MP0005645_abnormal_hypothalamus_physiol1.49839898
38MP0006082_CNS_inflammation1.47187602
39MP0002419_abnormal_innate_immunity1.43745265
40MP0001501_abnormal_sleep_pattern1.40924840
41MP0001905_abnormal_dopamine_level1.40208138
42MP0005025_abnormal_response_to1.35978198
43MP0002160_abnormal_reproductive_system1.35866434
44MP0002405_respiratory_system_inflammati1.33894777
45MP0005220_abnormal_exocrine_pancreas1.32090418
46MP0001790_abnormal_immune_system1.32001978
47MP0005387_immune_system_phenotype1.32001978
48MP0001986_abnormal_taste_sensitivity1.30481464
49MP0003943_abnormal_hepatobiliary_system1.28755230
50MP0005000_abnormal_immune_tolerance1.28422532
51MP0004885_abnormal_endolymph1.27821488
52MP0002876_abnormal_thyroid_physiology1.26365641
53MP0002452_abnormal_antigen_presenting1.25322565
54MP0002148_abnormal_hypersensitivity_rea1.24337679
55MP0002736_abnormal_nociception_after1.23681740
56MP0003646_muscle_fatigue1.23410211
57MP0005671_abnormal_response_to1.22816370
58MP0002723_abnormal_immune_serum1.20171939
59MP0008872_abnormal_physiological_respon1.17920613
60MP0001819_abnormal_immune_cell1.16279649
61MP0009745_abnormal_behavioral_response1.16139137
62MP0003880_abnormal_central_pattern1.15355037
63MP0006276_abnormal_autonomic_nervous1.15270133
64MP0002909_abnormal_adrenal_gland1.14217784
65MP0001800_abnormal_humoral_immune1.13615438
66MP0002420_abnormal_adaptive_immunity1.13075656
67MP0002735_abnormal_chemical_nociception1.12205446
68MP0001485_abnormal_pinna_reflex1.10248121
69MP0001545_abnormal_hematopoietic_system1.09101484
70MP0005397_hematopoietic_system_phenotyp1.09101484
71MP0003121_genomic_imprinting1.07687871
72MP0002272_abnormal_nervous_system1.04479855
73MP0001944_abnormal_pancreas_morphology1.04314211
74MP0006292_abnormal_olfactory_placode1.03441142
75MP0002693_abnormal_pancreas_physiology1.00772713
76MP0000470_abnormal_stomach_morphology1.00083395
77MP0003787_abnormal_imprinting0.99605896
78MP0002638_abnormal_pupillary_reflex0.99339754
79MP0003303_peritoneal_inflammation0.99242378
80MP0001765_abnormal_ion_homeostasis0.99173064
81MP0001853_heart_inflammation0.98343295
82MP0001486_abnormal_startle_reflex0.94164973
83MP0002557_abnormal_social/conspecific_i0.93148157
84MP0001970_abnormal_pain_threshold0.92017898
85MP0004142_abnormal_muscle_tone0.90991407
86MP0004742_abnormal_vestibular_system0.86803512
87MP0003638_abnormal_response/metabolism_0.86261354
88MP0005423_abnormal_somatic_nervous0.85636525
89MP0002398_abnormal_bone_marrow0.84775781
90MP0001845_abnormal_inflammatory_respons0.84086717
91MP0000716_abnormal_immune_system0.83880149
92MP0005464_abnormal_platelet_physiology0.81736457
93MP0002282_abnormal_trachea_morphology0.81611092
94MP0002064_seizures0.81448229
95MP0002733_abnormal_thermal_nociception0.80268795
96MP0001764_abnormal_homeostasis0.79706284
97MP0005195_abnormal_posterior_eye0.79490788
98MP0002234_abnormal_pharynx_morphology0.79210531
99MP0002938_white_spotting0.78929449
100MP0002229_neurodegeneration0.78540301
101MP0002063_abnormal_learning/memory/cond0.77419746
102MP0000372_irregular_coat_pigmentation0.77277191
103MP0003448_altered_tumor_morphology0.76639990
104MP0000858_altered_metastatic_potential0.75899636
105MP0000427_abnormal_hair_cycle0.75331541
106MP0008469_abnormal_protein_level0.75297811
107MP0003635_abnormal_synaptic_transmissio0.74646152
108MP0003136_yellow_coat_color0.74040309
109MP0004233_abnormal_muscle_weight0.73586328
110MP0010386_abnormal_urinary_bladder0.73506248
111MP0003953_abnormal_hormone_level0.72284637
112MP0003300_gastrointestinal_ulcer0.71555851
113MP0000343_altered_response_to0.69275532
114MP0000371_diluted_coat_color0.69216586
115MP0004145_abnormal_muscle_electrophysio0.68911016
116MP0002429_abnormal_blood_cell0.66405827
117MP0004147_increased_porphyrin_level0.66014592
118MP0000631_abnormal_neuroendocrine_gland0.65466963
119MP0000689_abnormal_spleen_morphology0.64999863
120MP0008569_lethality_at_weaning0.64329647
121MP0005389_reproductive_system_phenotype0.64261668
122MP0002734_abnormal_mechanical_nocicepti0.64178655
123MP0002102_abnormal_ear_morphology0.63934865
124MP0005167_abnormal_blood-brain_barrier0.63877426
125MP0002078_abnormal_glucose_homeostasis0.63741550
126MP0004043_abnormal_pH_regulation0.63233089
127MP0002882_abnormal_neuron_morphology0.62400361
128MP0001533_abnormal_skeleton_physiology0.62383654
129MP0005332_abnormal_amino_acid0.62175299
130MP0002752_abnormal_somatic_nervous0.61874512
131MP0000604_amyloidosis0.61457176
132MP0001873_stomach_inflammation0.61172037
133MP0005623_abnormal_meninges_morphology0.60236329
134MP0005647_abnormal_sex_gland0.59741486
135MP0008995_early_reproductive_senescence0.59488017
136MP0000358_abnormal_cell_content/0.59359799
137MP0003183_abnormal_peptide_metabolism0.59113268
138MP0000569_abnormal_digit_pigmentation0.58879505
139MP0004947_skin_inflammation0.58659693
140MP0005391_vision/eye_phenotype0.58328629
141MP0005386_behavior/neurological_phenoty0.58140733
142MP0004924_abnormal_behavior0.58140733
143MP0002138_abnormal_hepatobiliary_system0.57659111
144MP0002132_abnormal_respiratory_system0.57379371
145MP0005636_abnormal_mineral_homeostasis0.57278883
146MP0004510_myositis0.56293842
147MP0002722_abnormal_immune_system0.56143949
148MP0008058_abnormal_DNA_repair0.55969814
149MP0010307_abnormal_tumor_latency0.55765952
150MP0004808_abnormal_hematopoietic_stem0.54897684
151MP0001851_eye_inflammation0.54386793
152MP0009333_abnormal_splenocyte_physiolog0.53590840
153MP0002837_dystrophic_cardiac_calcinosis0.52234794
154MP0003950_abnormal_plasma_membrane0.51965139
155MP0010155_abnormal_intestine_physiology0.50209538
156MP0005310_abnormal_salivary_gland0.50182622
157MP0003329_amyloid_beta_deposits0.49909501
158MP0003763_abnormal_thymus_physiology0.49802470
159MP0009046_muscle_twitch0.49703280
160MP0001984_abnormal_olfaction0.47597436
161MP0000920_abnormal_myelination0.46891313
162MP0001348_abnormal_lacrimal_gland0.46554270
163MP0003111_abnormal_nucleus_morphology0.45779206
164MP0002928_abnormal_bile_duct0.45047143
165MP0003075_altered_response_to0.43902006
166MP0005166_decreased_susceptibility_to0.41095547
167MP0000703_abnormal_thymus_morphology0.40915307
168MP0002971_abnormal_brown_adipose0.40546988
169MP0003115_abnormal_respiratory_system0.40095587
170MP0006036_abnormal_mitochondrial_physio0.39150894
171MP0009115_abnormal_fat_cell0.37714021
172MP0004019_abnormal_vitamin_homeostasis0.37260736
173MP0000313_abnormal_cell_death0.36679161
174MP0005666_abnormal_adipose_tissue0.35670919
175MP0005058_abnormal_lysosome_morphology0.35422610
176MP0001324_abnormal_eye_pigmentation0.35092712
177MP0009764_decreased_sensitivity_to0.35081317
178MP0003879_abnormal_hair_cell0.34670260
179MP0005377_hearing/vestibular/ear_phenot0.33949463
180MP0003878_abnormal_ear_physiology0.33949463
181MP0003011_delayed_dark_adaptation0.32435460
182MP0005076_abnormal_cell_differentiation0.31536244

Predicted human phenotypes

RankGene SetZ-score
1Abnormal respiratory epithelium morphology (HP:0012253)8.81137540
2Abnormal respiratory motile cilium morphology (HP:0005938)8.81137540
3Abnormal respiratory motile cilium physiology (HP:0012261)8.48688334
4Amelogenesis imperfecta (HP:0000705)7.52608023
5Rhinitis (HP:0012384)7.07369750
6Nasal polyposis (HP:0100582)7.01067082
7Chronic bronchitis (HP:0004469)6.73015025
8Abnormal ciliary motility (HP:0012262)6.65578958
9Infertility (HP:0000789)6.40239849
10Abnormality of the nasal mucosa (HP:0000433)5.70979796
11Overgrowth (HP:0001548)5.44374742
12Abnormality of dental color (HP:0011073)5.29712906
13Abnormality of calcium-phosphate metabolism (HP:0100530)5.28733324
14Abnormality of renal resorption (HP:0011038)5.21432734
15Male infertility (HP:0003251)4.80695242
16Bronchitis (HP:0012387)4.76269211
17Bronchiectasis (HP:0002110)4.59218322
18Osteomalacia (HP:0002749)4.29832466
19Abnormal spermatogenesis (HP:0008669)4.17202362
20Recurrent sinusitis (HP:0011108)3.96250670
21Abnormality of the dental pulp (HP:0006479)3.83177871
22Congenital stationary night blindness (HP:0007642)3.45691856
23Nephronophthisis (HP:0000090)3.45392352
24Recurrent bronchitis (HP:0002837)3.45105336
25Recurrent otitis media (HP:0000403)3.38456453
26Pancreatic cysts (HP:0001737)3.28731698
27Azoospermia (HP:0000027)3.14933775
28Inability to walk (HP:0002540)3.14812214
29Pancreatic fibrosis (HP:0100732)3.13294547
30True hermaphroditism (HP:0010459)3.00371980
31Volvulus (HP:0002580)3.00109980
32Tachypnea (HP:0002789)2.89595555
33Drooling (HP:0002307)2.73253929
34Type II lissencephaly (HP:0007260)2.71486444
35Recurrent abscess formation (HP:0002722)2.63846232
36Attenuation of retinal blood vessels (HP:0007843)2.63758416
37Abnormal rod and cone electroretinograms (HP:0008323)2.62992951
38Abnormality of the renal medulla (HP:0100957)2.58278034
39Chronic hepatic failure (HP:0100626)2.56535684
40Excessive salivation (HP:0003781)2.52497012
41Recurrent gram-negative bacterial infections (HP:0005420)2.51711532
42Glycosuria (HP:0003076)2.49425019
43Abnormality of urine glucose concentration (HP:0011016)2.49425019
44Chronic sinusitis (HP:0011109)2.46051224
45Loss of speech (HP:0002371)2.43489337
46Impulsivity (HP:0100710)2.39083907
47Medial flaring of the eyebrow (HP:0010747)2.28089127
48Recurrent bacterial skin infections (HP:0005406)2.25490247
49Pendular nystagmus (HP:0012043)2.24790134
50Panhypogammaglobulinemia (HP:0003139)2.21294291
51Tubular atrophy (HP:0000092)2.14107290
52Chronic otitis media (HP:0000389)2.13285581
53Round ear (HP:0100830)2.12461988
54Nephrocalcinosis (HP:0000121)2.12086323
55Optic neuritis (HP:0100653)2.10616409
56Retrobulbar optic neuritis (HP:0100654)2.10616409
57Spastic tetraparesis (HP:0001285)2.10614845
58Abolished electroretinogram (ERG) (HP:0000550)2.08685042
59Keratoconus (HP:0000563)2.08254330
60Increased corneal curvature (HP:0100692)2.08254330
61Cystic liver disease (HP:0006706)2.07242247
62Eczematoid dermatitis (HP:0000976)2.04380285
63Gonadotropin excess (HP:0000837)2.04207872
64Tubulointerstitial nephritis (HP:0001970)2.03009232
65Severe muscular hypotonia (HP:0006829)2.02842993
66Abnormal drinking behavior (HP:0030082)2.01513265
67Polydipsia (HP:0001959)2.01513265
68Bony spicule pigmentary retinopathy (HP:0007737)2.01080271
69Hyperphosphaturia (HP:0003109)2.00889862
70Obstructive lung disease (HP:0006536)2.00224881
71Chronic obstructive pulmonary disease (HP:0006510)2.00224881
72Dynein arm defect of respiratory motile cilia (HP:0012255)12.4789270
73Absent/shortened dynein arms (HP:0200106)12.4789270
74Respiratory insufficiency due to defective ciliary clearance (HP:0200073)11.8794294
75Abnormality of midbrain morphology (HP:0002418)1.99930834
76Molar tooth sign on MRI (HP:0002419)1.99930834
77Toxemia of pregnancy (HP:0100603)1.99589138
78Optic nerve hypoplasia (HP:0000609)1.97163112
79Myositis (HP:0100614)1.95941635
80Tubulointerstitial abnormality (HP:0001969)1.95425275
81Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.92715345
82Abnormality of macular pigmentation (HP:0008002)1.88420016
83Absent rod-and cone-mediated responses on ERG (HP:0007688)1.88353821
84Depressed nasal tip (HP:0000437)1.88293717
85Orchitis (HP:0100796)1.86757239
86Aplasia/Hypoplasia of the fovea (HP:0008060)1.86002133
87Hypoplasia of the fovea (HP:0007750)1.86002133
88Nephropathy (HP:0000112)1.85889453
89Sclerocornea (HP:0000647)1.85727292
90Chorioretinal coloboma (HP:0000567)1.85572823
91Ectopic kidney (HP:0000086)1.85260059
92Large for gestational age (HP:0001520)1.85193175
93Cholecystitis (HP:0001082)1.83307711
94Abnormal gallbladder physiology (HP:0012438)1.83307711
95Choroideremia (HP:0001139)1.80471301
96Widely spaced teeth (HP:0000687)1.79538473
97IgM deficiency (HP:0002850)1.77232694
98Small hand (HP:0200055)1.75828228
99Easy fatigability (HP:0003388)1.75612914
100Decreased electroretinogram (ERG) amplitude (HP:0000654)1.74930727
101Tubulointerstitial fibrosis (HP:0005576)1.74578630
102Dyschromatopsia (HP:0007641)1.74006678
103Abnormality of renal excretion (HP:0011036)1.73263964
104Decreased circulating renin level (HP:0003351)1.73016577
105Severe visual impairment (HP:0001141)1.72422891
106Highly arched eyebrow (HP:0002553)1.72345956
107Congenital sensorineural hearing impairment (HP:0008527)1.71515594
108Progressive cerebellar ataxia (HP:0002073)1.69894813
109Congenital malformation of the right heart (HP:0011723)1.69618556
110Double outlet right ventricle (HP:0001719)1.69618556
111Heterotopia (HP:0002282)1.69022174
112Growth hormone deficiency (HP:0000824)1.68467142
113Prominent supraorbital ridges (HP:0000336)1.67396975
114Hypomagnesemia (HP:0002917)1.66980036
115Abnormality of transition element cation homeostasis (HP:0011030)1.66208997
116Male pseudohermaphroditism (HP:0000037)1.65967061
117Decreased muscle mass (HP:0003199)1.65586689
118Nephrogenic diabetes insipidus (HP:0009806)1.64314886
119Hypoplasia of the capital femoral epiphysis (HP:0003090)1.64015889
120Hyperventilation (HP:0002883)1.63793726
121Type 2 muscle fiber atrophy (HP:0003554)1.63530129
122Abnormal delayed hypersensitivity skin test (HP:0002963)1.63086813
123Abnormality of the neuromuscular junction (HP:0003398)1.62943107
124Fatigable weakness (HP:0003473)1.62943107
125Hypothermia (HP:0002045)1.62264011
126Abnormality of macrophages (HP:0004311)1.62238852
127Anencephaly (HP:0002323)1.61823448
128Short femoral neck (HP:0100864)1.61593736
129Intestinal atresia (HP:0011100)1.57692423
130Aplasia/Hypoplasia of the tongue (HP:0010295)1.57509484
131Delayed gross motor development (HP:0002194)1.54944118
132Aganglionic megacolon (HP:0002251)1.54736857
133Occipital encephalocele (HP:0002085)1.54597631
134Tongue fasciculations (HP:0001308)1.52151865
135Decreased central vision (HP:0007663)1.51468977
136Neurofibrillary tangles (HP:0002185)1.50872501
137Asymmetric septal hypertrophy (HP:0001670)1.45858790
138Abnormal urine output (HP:0012590)1.44553474
139J-shaped sella turcica (HP:0002680)1.44346512
140Muscle fiber atrophy (HP:0100295)1.40502692
141Deformed sella turcica (HP:0002681)1.40137110
142Hemorrhage of the eye (HP:0011885)1.39808329
143Aplasia/Hypoplasia involving the femoral head and neck (HP:0009108)1.39677475
144Congenital hepatic fibrosis (HP:0002612)1.39329617
145Postaxial foot polydactyly (HP:0001830)1.37760529
146Absent frontal sinuses (HP:0002688)1.36958035
147Stomatitis (HP:0010280)1.36092477
148Keratoconjunctivitis (HP:0001096)1.35754738
149Stage 5 chronic kidney disease (HP:0003774)1.35580488
150Vasculitis (HP:0002633)1.32479151
151Congenital primary aphakia (HP:0007707)1.32322382
152Muscle fibrillation (HP:0010546)1.32297769
153Abnormal biliary tract physiology (HP:0012439)1.32221095
154Bile duct proliferation (HP:0001408)1.32221095
155Gait imbalance (HP:0002141)1.30236018
156Personality changes (HP:0000751)1.29958873
157Polyuria (HP:0000103)1.28865836
158Keratoconjunctivitis sicca (HP:0001097)1.28488250
159Abnormality of the renal cortex (HP:0011035)1.27944310
160Abnormality of saccadic eye movements (HP:0000570)1.27579775
161Aplasia/Hypoplasia of the lens (HP:0008063)1.26986647
162Autoimmune thrombocytopenia (HP:0001973)1.26248142
163Mediastinal lymphadenopathy (HP:0100721)1.25796553
164Weak cry (HP:0001612)1.25213412
165Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)1.24900433
166Absent epiphyses (HP:0010577)1.24900433
167Cerebellar dysplasia (HP:0007033)1.24826010
168Gingivitis (HP:0000230)1.24324234
169Oculomotor apraxia (HP:0000657)1.22906124
170Testicular atrophy (HP:0000029)1.21760265

Predicted kinase interactions (KEA)

RankGene SetZ-score
1NTRK29.58635694
2PDK37.72719140
3PDK47.72719140
4TESK16.40080477
5PDK25.45649087
6PRKD34.32050615
7FRK3.86249791
8ICK3.83084721
9ADRBK22.59955898
10MAP4K22.55003239
11BMPR1B2.32017117
12WNK32.15972023
13INSRR2.07816519
14ACVR1B1.97141747
15PTK2B1.97015205
16GRK11.81036400
17DYRK1B1.80535743
18RIPK41.77905940
19STK391.60738090
20MAP4K11.60349210
21ZAK1.57022257
22NEK21.55978270
23PDK11.51333998
24STK381.50305765
25CASK1.49628488
26TLK11.47348600
27PNCK1.46071254
28WNK41.41003649
29BMPR21.40466049
30TESK21.35601558
31MAPK131.20620617
32OXSR11.14586527
33MAP3K41.07086675
34STK101.04409985
35MARK11.03971338
36TAOK31.01967696
37PDPK10.95653782
38CSK0.94574517
39TBK10.94445585
40TIE10.94355349
41PHKG10.93859264
42PHKG20.93859264
43IRAK40.93790664
44TRIM280.90594374
45IRAK10.88978761
46TGFBR10.88912162
47DAPK20.84951490
48PAK30.83871543
49NTRK30.81890374
50LMTK20.81795301
51MAP2K60.80667056
52PRKCE0.75669357
53PLK40.73429899
54CDC42BPA0.70966365
55HIPK20.69995446
56ADRBK10.68174787
57STK30.67408715
58PLK20.67364242
59CSF1R0.67027295
60PRKAA10.66994036
61TNIK0.63833672
62EPHB10.63442011
63DYRK20.62832093
64CAMK2A0.60325533
65ZAP700.60218200
66VRK10.59651221
67BTK0.59158256
68IRAK20.59122639
69CAMKK20.58515729
70TYK20.57601018
71MAP2K70.57451527
72ITK0.57427656
73PAK40.57093096
74TXK0.56479813
75HCK0.55730805
76DYRK30.54979266
77OBSCN0.54544961
78PRKACA0.54427486
79BLK0.53690078
80MAP3K140.53475351
81TEC0.53323346
82CLK10.50741047
83FGFR20.50699880
84MARK30.49393189
85CSNK1G20.47758423
86PAK10.46471589
87BCKDK0.45775163
88PRKG20.45657981
89EEF2K0.45016500
90MAP3K100.44857450
91PIM10.44561004
92FGFR10.43218855
93CSNK1G30.42009335
94PIK3CA0.41974533
95CHEK20.41868947
96CSNK1G10.39960879
97PASK0.39653423
98PRKCQ0.39186103
99BCR0.39134601
100CSNK1A10.38984850
101ROCK10.38679339
102ABL10.38060523
103PRKACB0.37976899
104PRKACG0.37148920
105CHUK0.37087977
106CAMK10.36869306
107PRKCA0.36026296
108SYK0.35071471
109GRK60.34793505
110MKNK20.34712883
111MST40.34521692
112ERBB30.34312511
113PLK30.34057933
114PRKCD0.33983885
115PIK3CG0.33044772
116GRK70.31904352
117PLK10.31478423
118SRC0.31438203
119SRPK10.30704545
120PRKG10.30042001
121ERN10.29547991
122EPHA40.28177645
123WNK10.27826845
124PKN10.27128809
125MAPKAPK30.27110933
126LCK0.27108825
127TTK0.26952408
128FER0.26115355
129TYRO30.25767795
130MAP3K50.25629539
131PRKCB0.25173022
132PRKCI0.25139336
133IKBKB0.25071113
134ROCK20.25053934
135CAMK2D0.24273603
136NEK60.22648581
137MUSK0.22107081
138WEE10.21715576
139FGR0.21637970
140CHEK10.20866595
141EGFR0.19890107
142IKBKE0.19618318
143CAMK1G0.19268254
144CCNB10.19185834
145MAPK150.18713503
146CDK120.18127809
147LYN0.18059820
148FES0.15865844
149MAP3K30.15352377
150RPS6KA40.14466715
151MAP2K30.14362909
152ATM0.13955272
153MAP3K80.13675695
154JAK10.12495052
155RPS6KA10.11979651
156RPS6KB10.11864921
157STK38L0.11863439
158KIT0.11723950
159STK110.10178766
160PRKCG0.09842795
161MELK0.09838952
162JAK30.09828039
163TRIB30.09792552
164STK240.09788903
165PRKCZ0.08841088
166YES10.08274766
167CSNK2A10.08207507
168KDR0.07870920
169TGFBR20.07554233
170INSR0.07504186
171NUAK10.06641385
172BUB10.06319192
173PINK10.06099189

Predicted pathways (KEGG)

RankGene SetZ-score
1Olfactory transduction_Homo sapiens_hsa047404.60844924
2Fatty acid biosynthesis_Homo sapiens_hsa000613.78655322
3Glycolysis / Gluconeogenesis_Homo sapiens_hsa000103.72252008
4Sulfur relay system_Homo sapiens_hsa041223.24018099
5Sulfur metabolism_Homo sapiens_hsa009202.75657257
6Ovarian steroidogenesis_Homo sapiens_hsa049132.74520708
7alpha-Linolenic acid metabolism_Homo sapiens_hsa005922.70314386
8Linoleic acid metabolism_Homo sapiens_hsa005912.54743700
9Vitamin B6 metabolism_Homo sapiens_hsa007502.51091928
10Butirosin and neomycin biosynthesis_Homo sapiens_hsa005242.49724461
11Antigen processing and presentation_Homo sapiens_hsa046122.33096877
12Pyruvate metabolism_Homo sapiens_hsa006202.25893176
13Glycosaminoglycan degradation_Homo sapiens_hsa005312.23645891
14Legionellosis_Homo sapiens_hsa051342.17028975
15Basal transcription factors_Homo sapiens_hsa030222.14623531
16Carbohydrate digestion and absorption_Homo sapiens_hsa049732.14399034
17Morphine addiction_Homo sapiens_hsa050321.96734961
18Pentose phosphate pathway_Homo sapiens_hsa000301.96347795
19Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.91752142
20Salivary secretion_Homo sapiens_hsa049701.90805261
21Insulin secretion_Homo sapiens_hsa049111.89391788
22Taste transduction_Homo sapiens_hsa047421.88670979
23Circadian entrainment_Homo sapiens_hsa047131.80335017
24Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.78005025
25Glutamatergic synapse_Homo sapiens_hsa047241.75024712
26GABAergic synapse_Homo sapiens_hsa047271.74329651
27Synaptic vesicle cycle_Homo sapiens_hsa047211.74023292
28Glycerolipid metabolism_Homo sapiens_hsa005611.70612648
29Mineral absorption_Homo sapiens_hsa049781.70407528
30Bile secretion_Homo sapiens_hsa049761.68517895
31Gastric acid secretion_Homo sapiens_hsa049711.62433600
32Thyroid hormone synthesis_Homo sapiens_hsa049181.62380912
33Glucagon signaling pathway_Homo sapiens_hsa049221.62018698
34Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.61625050
35Selenocompound metabolism_Homo sapiens_hsa004501.59596378
36Cocaine addiction_Homo sapiens_hsa050301.58891586
37Pancreatic secretion_Homo sapiens_hsa049721.58262342
38Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.56437385
39Glycerophospholipid metabolism_Homo sapiens_hsa005641.55985262
40Regulation of lipolysis in adipocytes_Homo sapiens_hsa049231.54684072
41Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.54207758
42B cell receptor signaling pathway_Homo sapiens_hsa046621.54141662
43Phototransduction_Homo sapiens_hsa047441.53841688
44Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.48194402
45Propanoate metabolism_Homo sapiens_hsa006401.46422918
46Glutathione metabolism_Homo sapiens_hsa004801.44880235
47Ether lipid metabolism_Homo sapiens_hsa005651.42202244
48Dorso-ventral axis formation_Homo sapiens_hsa043201.41734947
49Aldosterone synthesis and secretion_Homo sapiens_hsa049251.40653521
50Vascular smooth muscle contraction_Homo sapiens_hsa042701.38236657
51Butanoate metabolism_Homo sapiens_hsa006501.38035077
52Vibrio cholerae infection_Homo sapiens_hsa051101.33746089
53Leishmaniasis_Homo sapiens_hsa051401.33336867
54Oxidative phosphorylation_Homo sapiens_hsa001901.32121371
55Fructose and mannose metabolism_Homo sapiens_hsa000511.30409592
56PPAR signaling pathway_Homo sapiens_hsa033201.29600847
57Oocyte meiosis_Homo sapiens_hsa041141.29338899
58Staphylococcus aureus infection_Homo sapiens_hsa051501.25873908
59Maturity onset diabetes of the young_Homo sapiens_hsa049501.23992736
60Nitrogen metabolism_Homo sapiens_hsa009101.20837088
61Osteoclast differentiation_Homo sapiens_hsa043801.20489535
62Salmonella infection_Homo sapiens_hsa051321.20257920
63Caffeine metabolism_Homo sapiens_hsa002321.18870000
64Measles_Homo sapiens_hsa051621.18646850
65Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.16741662
66Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.10483853
67T cell receptor signaling pathway_Homo sapiens_hsa046601.09374886
68Collecting duct acid secretion_Homo sapiens_hsa049661.08932847
69Calcium signaling pathway_Homo sapiens_hsa040201.08837734
70Longevity regulating pathway - multiple species_Homo sapiens_hsa042131.08581266
71Serotonergic synapse_Homo sapiens_hsa047261.07951835
72Shigellosis_Homo sapiens_hsa051311.07804646
73Parkinsons disease_Homo sapiens_hsa050121.05732374
74Nicotine addiction_Homo sapiens_hsa050331.01712850
75Graft-versus-host disease_Homo sapiens_hsa053321.01188826
76Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.00791187
77Circadian rhythm_Homo sapiens_hsa047100.99831146
78Asthma_Homo sapiens_hsa053100.98736180
79RNA degradation_Homo sapiens_hsa030180.98324203
80Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.98183308
81Oxytocin signaling pathway_Homo sapiens_hsa049210.97500465
82Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.97054982
83Cholinergic synapse_Homo sapiens_hsa047250.92635106
84Fatty acid metabolism_Homo sapiens_hsa012120.89450619
85Toxoplasmosis_Homo sapiens_hsa051450.89108501
86NF-kappa B signaling pathway_Homo sapiens_hsa040640.88746140
87RNA transport_Homo sapiens_hsa030130.87744414
88Dilated cardiomyopathy_Homo sapiens_hsa054140.86775725
89Allograft rejection_Homo sapiens_hsa053300.86154560
90Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.85717123
91Fat digestion and absorption_Homo sapiens_hsa049750.85610329
92Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.85467735
93Fanconi anemia pathway_Homo sapiens_hsa034600.84915261
94Endocytosis_Homo sapiens_hsa041440.83097112
95Influenza A_Homo sapiens_hsa051640.82979929
96Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.82627285
97Primary immunodeficiency_Homo sapiens_hsa053400.80566275
98Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.80261002
99Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.80183034
100Longevity regulating pathway - mammal_Homo sapiens_hsa042110.79806254
101Rheumatoid arthritis_Homo sapiens_hsa053230.79249669
102Hematopoietic cell lineage_Homo sapiens_hsa046400.77706292
103Carbon metabolism_Homo sapiens_hsa012000.77648175
104Purine metabolism_Homo sapiens_hsa002300.77286989
105Adipocytokine signaling pathway_Homo sapiens_hsa049200.76545529
106Arachidonic acid metabolism_Homo sapiens_hsa005900.76444516
107Other glycan degradation_Homo sapiens_hsa005110.76381762
108Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.75736099
109Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.74688596
110Proteasome_Homo sapiens_hsa030500.74609225
111mRNA surveillance pathway_Homo sapiens_hsa030150.74226793
112Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.72509450
113Gap junction_Homo sapiens_hsa045400.71781018
114Epstein-Barr virus infection_Homo sapiens_hsa051690.71562390
115Tryptophan metabolism_Homo sapiens_hsa003800.70286259
116Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.69903891
117Leukocyte transendothelial migration_Homo sapiens_hsa046700.67519661
118Melanogenesis_Homo sapiens_hsa049160.66705712
119Huntingtons disease_Homo sapiens_hsa050160.66562969
120Steroid hormone biosynthesis_Homo sapiens_hsa001400.65553077
121Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.65550029
122Systemic lupus erythematosus_Homo sapiens_hsa053220.65241142
123Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.65072829
124ABC transporters_Homo sapiens_hsa020100.64495535
125Phagosome_Homo sapiens_hsa041450.63589395
126Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.63576595
127Malaria_Homo sapiens_hsa051440.62822582
128TNF signaling pathway_Homo sapiens_hsa046680.62711512
129NOD-like receptor signaling pathway_Homo sapiens_hsa046210.61144361
130Tuberculosis_Homo sapiens_hsa051520.60340557
131Chemical carcinogenesis_Homo sapiens_hsa052040.59892371
132Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.58870854
133GnRH signaling pathway_Homo sapiens_hsa049120.58727640
134Herpes simplex infection_Homo sapiens_hsa051680.58619529
135Intestinal immune network for IgA production_Homo sapiens_hsa046720.58069184
136Retinol metabolism_Homo sapiens_hsa008300.57152543
137Pyrimidine metabolism_Homo sapiens_hsa002400.54856714
138Estrogen signaling pathway_Homo sapiens_hsa049150.54811376
139Primary bile acid biosynthesis_Homo sapiens_hsa001200.53879589
140Lysosome_Homo sapiens_hsa041420.52880150
141Fatty acid degradation_Homo sapiens_hsa000710.51998789
142Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.51292186
143Dopaminergic synapse_Homo sapiens_hsa047280.51150750
144Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.50742350
145Pentose and glucuronate interconversions_Homo sapiens_hsa000400.50324764
146Toll-like receptor signaling pathway_Homo sapiens_hsa046200.50049181
147Platelet activation_Homo sapiens_hsa046110.49981461
148Renin secretion_Homo sapiens_hsa049240.49601589
149Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.49003976
150RNA polymerase_Homo sapiens_hsa030200.48582209
151Cardiac muscle contraction_Homo sapiens_hsa042600.47212706
152cAMP signaling pathway_Homo sapiens_hsa040240.47015336
153Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.46968720
154Jak-STAT signaling pathway_Homo sapiens_hsa046300.46425940
155Inositol phosphate metabolism_Homo sapiens_hsa005620.46181318
156VEGF signaling pathway_Homo sapiens_hsa043700.45917707
157Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.45247509
158Cysteine and methionine metabolism_Homo sapiens_hsa002700.43730546
159Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.42561559
160Amphetamine addiction_Homo sapiens_hsa050310.42188361
161Type I diabetes mellitus_Homo sapiens_hsa049400.41888972
162Homologous recombination_Homo sapiens_hsa034400.40658684
163Viral carcinogenesis_Homo sapiens_hsa052030.39661792
164Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.36442121
165African trypanosomiasis_Homo sapiens_hsa051430.34306598
166Central carbon metabolism in cancer_Homo sapiens_hsa052300.32089414
167Phosphatidylinositol signaling system_Homo sapiens_hsa040700.31541215
168Alzheimers disease_Homo sapiens_hsa050100.30362110
169Protein export_Homo sapiens_hsa030600.29247558
170Peroxisome_Homo sapiens_hsa041460.28865873
171Hedgehog signaling pathway_Homo sapiens_hsa043400.28440926

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