SLC36A4

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: SLC36A4 belongs to the SLC36 family of amino acid transporters based on sequence similarity with other family members (e.g., SLC36A1; MIM 606561). SLC36 proteins contain about 500 amino acids and have 9 to 11 transmembrane domains. Unlike other SLC36 family members, which are proton-coupled amino acid transporters, SLC36A4 is a high-affinity/low-capacity non-proton-coupled amino acid transporter (Pillai and Meredith, 2011 [PubMed 21097500]). NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1synaptic vesicle maturation (GO:0016188)4.88512958
2regulation of short-term neuronal synaptic plasticity (GO:0048172)4.85502913
3locomotory exploration behavior (GO:0035641)4.55302594
4synaptic vesicle exocytosis (GO:0016079)4.53719993
5inositol phosphate catabolic process (GO:0071545)4.34686481
6positive regulation of calcium ion-dependent exocytosis (GO:0045956)4.32699342
7regulation of synaptic vesicle exocytosis (GO:2000300)4.31668443
8vocalization behavior (GO:0071625)4.31618697
9positive regulation of excitatory postsynaptic membrane potential (GO:2000463)4.25098309
10inositol phosphate dephosphorylation (GO:0046855)4.14465097
11phosphorylated carbohydrate dephosphorylation (GO:0046838)4.14465097
12glutamate secretion (GO:0014047)4.05173289
13regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act4.02964072
14regulation of ER to Golgi vesicle-mediated transport (GO:0060628)4.00820508
15regulation of glutamate receptor signaling pathway (GO:1900449)3.89040194
16synaptic vesicle docking involved in exocytosis (GO:0016081)3.85634700
17insulin secretion (GO:0030073)3.78739355
18layer formation in cerebral cortex (GO:0021819)3.76061695
19regulation of synaptic vesicle transport (GO:1902803)3.75906791
20regulation of Rac protein signal transduction (GO:0035020)3.74682285
21glycerophospholipid catabolic process (GO:0046475)3.74194340
22neuron cell-cell adhesion (GO:0007158)3.73237213
23neurotransmitter secretion (GO:0007269)3.72007485
24exploration behavior (GO:0035640)3.66128512
25presynaptic membrane organization (GO:0097090)3.65042534
26ionotropic glutamate receptor signaling pathway (GO:0035235)3.64838804
27response to pheromone (GO:0019236)3.63961827
28protein localization to synapse (GO:0035418)3.61866088
29somite rostral/caudal axis specification (GO:0032525)3.60648603
30regulation of synapse structural plasticity (GO:0051823)3.57006669
31kidney morphogenesis (GO:0060993)3.50919765
32regulation of glucokinase activity (GO:0033131)3.50150589
33regulation of hexokinase activity (GO:1903299)3.50150589
34activation of protein kinase A activity (GO:0034199)3.48587212
35polyol catabolic process (GO:0046174)3.46806749
36* proline transport (GO:0015824)3.44306575
37regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)3.44253991
38protein localization to cilium (GO:0061512)3.43538578
39regulation of long-term neuronal synaptic plasticity (GO:0048169)3.39799698
40dendritic spine morphogenesis (GO:0060997)3.37521687
41regulation of neuronal synaptic plasticity (GO:0048168)3.32800746
42cellular ketone body metabolic process (GO:0046950)3.27458785
43neuron recognition (GO:0008038)3.27160447
44signal peptide processing (GO:0006465)3.24042160
45neuronal action potential propagation (GO:0019227)3.22477139
46gamma-aminobutyric acid transport (GO:0015812)3.21608138
47negative regulation of cytosolic calcium ion concentration (GO:0051481)3.19532531
48establishment of protein localization to Golgi (GO:0072600)3.18582421
49cellular potassium ion homeostasis (GO:0030007)3.17892813
50glutamate receptor signaling pathway (GO:0007215)3.16774641
51dendrite morphogenesis (GO:0048813)3.16185523
52positive regulation of histone H3-K4 methylation (GO:0051571)3.15970736
53pteridine-containing compound biosynthetic process (GO:0042559)3.15934826
54axonal fasciculation (GO:0007413)3.15406967
55nonmotile primary cilium assembly (GO:0035058)3.14507378
56epithelial cilium movement (GO:0003351)3.09665402
57protein targeting to Golgi (GO:0000042)3.07909406
58neurotransmitter-gated ion channel clustering (GO:0072578)3.06291014
59vesicle transport along microtubule (GO:0047496)3.03163419
60membrane depolarization during cardiac muscle cell action potential (GO:0086012)2.97696593
61synaptic vesicle endocytosis (GO:0048488)2.97608042
62regulation of excitatory postsynaptic membrane potential (GO:0060079)2.97242487
63mitotic sister chromatid cohesion (GO:0007064)2.97206432
64synaptic transmission, glutamatergic (GO:0035249)2.95505896
65neuron-neuron synaptic transmission (GO:0007270)2.93618080
66regulation of ARF protein signal transduction (GO:0032012)2.93126781
67neurotransmitter transport (GO:0006836)2.92961603
68cerebellar Purkinje cell differentiation (GO:0021702)2.92372480
69ketone body metabolic process (GO:1902224)2.92115905
70clathrin coat assembly (GO:0048268)2.92038727
71auditory receptor cell differentiation (GO:0042491)2.91099505
72platelet dense granule organization (GO:0060155)2.90592407
73mating behavior (GO:0007617)2.89637331
74sodium ion export (GO:0071436)2.89574318
75regulation of acetyl-CoA biosynthetic process from pyruvate (GO:0010510)2.89276807
76long-term memory (GO:0007616)2.86921063
77intraciliary transport (GO:0042073)2.86328324
78nucleobase catabolic process (GO:0046113)2.86078249
79respiratory chain complex IV assembly (GO:0008535)2.83891378
80regulation of postsynaptic membrane potential (GO:0060078)2.83080523
81retrograde transport, vesicle recycling within Golgi (GO:0000301)2.81828767
82cilium morphogenesis (GO:0060271)2.81455886
83water-soluble vitamin biosynthetic process (GO:0042364)2.80361374
84cytochrome complex assembly (GO:0017004)2.79523581
85long-term synaptic potentiation (GO:0060291)2.78702883
86endocrine pancreas development (GO:0031018)2.78454008
87negative regulation of synaptic transmission, GABAergic (GO:0032229)2.74552810
88protein K11-linked deubiquitination (GO:0035871)2.74370717
89cilium organization (GO:0044782)2.74171550
90negative regulation of hormone biosynthetic process (GO:0032353)2.73540897
91protein localization to Golgi apparatus (GO:0034067)2.73539972
92negative regulation of execution phase of apoptosis (GO:1900118)2.73282599
93regulation of neurotransmitter secretion (GO:0046928)2.72723034
94prepulse inhibition (GO:0060134)2.72449505
95cilium assembly (GO:0042384)2.72157150
96regulation of acyl-CoA biosynthetic process (GO:0050812)2.71607212
97regulation of inhibitory postsynaptic membrane potential (GO:0060080)2.71025459
98glycine transport (GO:0015816)2.70857456
99neuromuscular process controlling balance (GO:0050885)2.70736809
100regulation of respiratory gaseous exchange by neurological system process (GO:0002087)2.70469283
101gamma-aminobutyric acid signaling pathway (GO:0007214)2.69980585
102positive regulation of membrane potential (GO:0045838)2.69939846
103regulation of cilium movement (GO:0003352)2.69803872
104snRNA transcription (GO:0009301)2.68732984
105regulation of synaptic plasticity (GO:0048167)2.67871126
106detection of calcium ion (GO:0005513)2.67839469
107cerebellar Purkinje cell layer development (GO:0021680)2.67766969
108positive regulation of potassium ion transmembrane transporter activity (GO:1901018)2.67624525
109G-protein coupled acetylcholine receptor signaling pathway (GO:0007213)2.67273313
110positive regulation of synaptic transmission, GABAergic (GO:0032230)2.66703801
111regulation of neurotransmitter levels (GO:0001505)2.66683988
112intra-Golgi vesicle-mediated transport (GO:0006891)2.65929974
113photoreceptor cell maintenance (GO:0045494)2.65632860
114limb development (GO:0060173)2.65443684
115appendage development (GO:0048736)2.65443684
116epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)2.65094026
117regulation of vesicle fusion (GO:0031338)2.64460227
118positive regulation of insulin secretion involved in cellular response to glucose stimulus (GO:003572.64447659
119neuron fate determination (GO:0048664)2.64307210
120establishment of nucleus localization (GO:0040023)2.63586378
121regulation of type B pancreatic cell apoptotic process (GO:2000674)2.63071969
122cilium movement (GO:0003341)2.62888811
123determination of left/right symmetry (GO:0007368)2.62367081
124innervation (GO:0060384)2.62274554
125regulation of dendritic spine morphogenesis (GO:0061001)2.61867006
126behavioral response to nicotine (GO:0035095)2.60880797
127retinal ganglion cell axon guidance (GO:0031290)2.57985935
128response to auditory stimulus (GO:0010996)2.57861636
129regulation of synaptic transmission, glutamatergic (GO:0051966)2.57627988
130response to histamine (GO:0034776)2.57187182
131positive regulation of synaptic transmission, glutamatergic (GO:0051968)2.56893189
132positive regulation of synaptic transmission, dopaminergic (GO:0032226)2.56765400
133pyrimidine nucleobase catabolic process (GO:0006208)2.56747440
134synapse assembly (GO:0007416)2.55662496
135olfactory bulb development (GO:0021772)2.55316299
136determination of bilateral symmetry (GO:0009855)2.55056592
137organelle transport along microtubule (GO:0072384)2.53258012
138presynaptic membrane assembly (GO:0097105)2.52746846
139neuromuscular process controlling posture (GO:0050884)2.52599320
140potassium ion import (GO:0010107)2.52525849
141negative regulation of DNA-dependent DNA replication (GO:2000104)2.51833091
142protein complex biogenesis (GO:0070271)2.50790354
143pancreas development (GO:0031016)2.50698685
144suckling behavior (GO:0001967)2.50636600
145atrial cardiac muscle cell action potential (GO:0086014)2.50385344
146specification of symmetry (GO:0009799)2.49938685
147regulation of clathrin-mediated endocytosis (GO:2000369)2.49040380
148membrane depolarization during action potential (GO:0086010)2.48985468
149protein prenylation (GO:0018342)2.48854521
150prenylation (GO:0097354)2.48854521
151nerve growth factor signaling pathway (GO:0038180)2.48466793
152peptidyl-cysteine modification (GO:0018198)2.48260915
153membrane depolarization (GO:0051899)2.48240077
154regulation of neurotransmitter transport (GO:0051588)2.47141316
155C-terminal protein lipidation (GO:0006501)2.47108921
156positive regulation of synapse maturation (GO:0090129)2.47074949
157transmission of nerve impulse (GO:0019226)2.46161026
158postsynaptic membrane organization (GO:0001941)2.46018269
159magnesium ion transport (GO:0015693)2.45671208
160cardiac left ventricle morphogenesis (GO:0003214)2.45055823
161establishment of synaptic vesicle localization (GO:0097480)2.45005640
162synaptic vesicle transport (GO:0048489)2.45005640
163positive regulation of insulin secretion (GO:0032024)2.44889376
164lactate metabolic process (GO:0006089)2.44818343
165early endosome to late endosome transport (GO:0045022)2.44386151
166melanosome transport (GO:0032402)2.43890812
167signal release (GO:0023061)2.42750653
168reflex (GO:0060004)2.41859728
169anterograde synaptic vesicle transport (GO:0048490)2.41759343
170axon cargo transport (GO:0008088)2.41236210
171regulation of neurotransmitter uptake (GO:0051580)2.40391326
172regulation of synaptic transmission, GABAergic (GO:0032228)2.39346393
173negative regulation of dendrite morphogenesis (GO:0050774)2.39242230
174positive regulation of vesicle fusion (GO:0031340)2.39229062
175positive regulation of synaptic transmission (GO:0050806)2.38791730
176regulation of coenzyme metabolic process (GO:0051196)2.38330460
177regulation of cofactor metabolic process (GO:0051193)2.38330460
178intraspecies interaction between organisms (GO:0051703)2.37439138
179social behavior (GO:0035176)2.37439138
180positive regulation of macroautophagy (GO:0016239)2.37319341
181peptide hormone secretion (GO:0030072)2.37261055
182regulation of cAMP-dependent protein kinase activity (GO:2000479)2.36975075
183protein K6-linked ubiquitination (GO:0085020)2.36827469
184regulation of sulfur metabolic process (GO:0042762)2.36768428
185synapse organization (GO:0050808)2.36557769
186establishment of melanosome localization (GO:0032401)2.36286498
187negative regulation of amyloid precursor protein catabolic process (GO:1902992)2.35981727
188positive regulation of protein autophosphorylation (GO:0031954)2.35276961
189peptide secretion (GO:0002790)2.34548500
190C-terminal protein amino acid modification (GO:0018410)2.33535191
191artery development (GO:0060840)2.33364387
192mitochondrial respiratory chain complex assembly (GO:0033108)2.31796965
193nitric oxide mediated signal transduction (GO:0007263)2.30366649
194righting reflex (GO:0060013)2.29900891
195pigment granule transport (GO:0051904)2.29660318

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human4.38388362
2SALL1_21062744_ChIP-ChIP_HESCs_Human3.24673731
3GBX2_23144817_ChIP-Seq_PC3_Human3.19965237
4FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse3.09069349
5SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.75522304
6SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.70797823
7FUS_26573619_Chip-Seq_HEK293_Human2.69094339
8JARID2_20064375_ChIP-Seq_MESCs_Mouse2.53149566
9SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.42443222
10RNF2_18974828_ChIP-Seq_MESCs_Mouse2.37893254
11EZH2_18974828_ChIP-Seq_MESCs_Mouse2.37893254
12SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.36085690
13EWS_26573619_Chip-Seq_HEK293_Human2.35875798
14SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.30760572
15* MTF2_20144788_ChIP-Seq_MESCs_Mouse2.27289413
16* SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.20843305
17JARID2_20075857_ChIP-Seq_MESCs_Mouse2.18757491
18EZH2_27304074_Chip-Seq_ESCs_Mouse2.09998910
19FLI1_27457419_Chip-Seq_LIVER_Mouse2.08002240
20DROSHA_22980978_ChIP-Seq_HELA_Human2.07715394
21REST_21632747_ChIP-Seq_MESCs_Mouse2.03317346
22EED_16625203_ChIP-ChIP_MESCs_Mouse1.98615706
23RNF2_27304074_Chip-Seq_ESCs_Mouse1.89720292
24MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.89275800
25SUZ12_27294783_Chip-Seq_ESCs_Mouse1.88569653
26MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.86797220
27AR_21572438_ChIP-Seq_LNCaP_Human1.83598609
28RARB_27405468_Chip-Seq_BRAIN_Mouse1.82273319
29EZH2_27294783_Chip-Seq_ESCs_Mouse1.81259002
30VDR_22108803_ChIP-Seq_LS180_Human1.75419134
31CDX2_19796622_ChIP-Seq_MESCs_Mouse1.75181880
32RBPJ_22232070_ChIP-Seq_NCS_Mouse1.74708111
33SMAD_19615063_ChIP-ChIP_OVARY_Human1.74494679
34TAF15_26573619_Chip-Seq_HEK293_Human1.69916316
35IKZF1_21737484_ChIP-ChIP_HCT116_Human1.67733687
36CTBP2_25329375_ChIP-Seq_LNCAP_Human1.67726860
37PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.67655312
38SMAD4_21799915_ChIP-Seq_A2780_Human1.67255215
39PCGF2_27294783_Chip-Seq_ESCs_Mouse1.66092863
40ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.65921073
41RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.64924507
42GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.63948344
43IGF1R_20145208_ChIP-Seq_DFB_Human1.62273700
44GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.57003559
45ELK1_19687146_ChIP-ChIP_HELA_Human1.56327694
46CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.54955768
47NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.53526004
48CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.52747904
49HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.52645231
50ZNF217_24962896_ChIP-Seq_MCF-7_Human1.51758311
51NR3C1_23031785_ChIP-Seq_PC12_Mouse1.51305061
52REST_18959480_ChIP-ChIP_MESCs_Mouse1.51038726
53P300_19829295_ChIP-Seq_ESCs_Human1.47769165
54SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.47399884
55CTBP1_25329375_ChIP-Seq_LNCAP_Human1.45915824
56ZFP57_27257070_Chip-Seq_ESCs_Mouse1.45731703
57EZH2_27294783_Chip-Seq_NPCs_Mouse1.42561400
58UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.41854097
59SUZ12_27294783_Chip-Seq_NPCs_Mouse1.41815219
60PIAS1_25552417_ChIP-Seq_VCAP_Human1.41421850
61SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.40886699
62OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.40486082
63EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.40364573
64ZNF274_21170338_ChIP-Seq_K562_Hela1.38755364
65VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.38591829
66HTT_18923047_ChIP-ChIP_STHdh_Human1.37486891
67PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.36611298
68SOX2_21211035_ChIP-Seq_LN229_Gbm1.35463954
69AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.34567667
70AR_25329375_ChIP-Seq_VCAP_Human1.33814260
71SMAD3_21741376_ChIP-Seq_EPCs_Human1.33573491
72RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.32847854
73POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.32176177
74TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.32176177
75POU3F2_20337985_ChIP-ChIP_501MEL_Human1.32145869
76SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.31874161
77KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.31617144
78MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.31341250
79ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.29408480
80TOP2B_26459242_ChIP-Seq_MCF-7_Human1.28880094
81ARNT_22903824_ChIP-Seq_MCF-7_Human1.28619753
82CBP_20019798_ChIP-Seq_JUKART_Human1.28548718
83IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.28548718
84E2F1_18555785_Chip-Seq_ESCs_Mouse1.28127618
85PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.28015550
86P53_22387025_ChIP-Seq_ESCs_Mouse1.27958213
87TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.27931737
88TP53_18474530_ChIP-ChIP_U2OS_Human1.27241147
89STAT3_23295773_ChIP-Seq_U87_Human1.26609324
90SUZ12_18555785_Chip-Seq_ESCs_Mouse1.26430362
91CMYC_18555785_Chip-Seq_ESCs_Mouse1.26078290
92NFE2_27457419_Chip-Seq_LIVER_Mouse1.25892126
93AHR_22903824_ChIP-Seq_MCF-7_Human1.23678887
94TRIM28_21343339_ChIP-Seq_HEK293_Human1.22854720
95MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.22774663
96FLI1_21867929_ChIP-Seq_TH2_Mouse1.22739509
97CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.21653674
98TP53_16413492_ChIP-PET_HCT116_Human1.21515174
99TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.19590500
100EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.19268739
101WT1_25993318_ChIP-Seq_PODOCYTE_Human1.18838484
102SOX2_19829295_ChIP-Seq_ESCs_Human1.18312640
103NANOG_19829295_ChIP-Seq_ESCs_Human1.18312640
104TCF4_22108803_ChIP-Seq_LS180_Human1.17715145
105* TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.17552412
106TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.17043977
107PCGF2_27294783_Chip-Seq_NPCs_Mouse1.16677874
108NRF2_20460467_ChIP-Seq_MEFs_Mouse1.15311357
109NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.15311357
110TP53_22573176_ChIP-Seq_HFKS_Human1.14905922
111STAT3_18555785_Chip-Seq_ESCs_Mouse1.14867963
112WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.14722526
113AR_19668381_ChIP-Seq_PC3_Human1.14646297
114KLF5_20875108_ChIP-Seq_MESCs_Mouse1.14424256
115BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.14398807
116EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse1.13896013
117GABP_17652178_ChIP-ChIP_JURKAT_Human1.12765465
118CBX2_27304074_Chip-Seq_ESCs_Mouse1.12371436
119SOX2_18555785_Chip-Seq_ESCs_Mouse1.12040735
120BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.11167050
121P300_18555785_Chip-Seq_ESCs_Mouse1.09926955
122HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.09775504
123BCAT_22108803_ChIP-Seq_LS180_Human1.09400517
124NR3C1_21868756_ChIP-Seq_MCF10A_Human1.09315955
125TCF4_23295773_ChIP-Seq_U87_Human1.08934994
126RXR_22108803_ChIP-Seq_LS180_Human1.08658601
127* YAP1_20516196_ChIP-Seq_MESCs_Mouse1.08171977
128STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse1.07928663
129CRX_20693478_ChIP-Seq_RETINA_Mouse1.07366266
130EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.06876858
131TAL1_26923725_Chip-Seq_HPCs_Mouse1.06521580
132PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.06478432
133WT1_19549856_ChIP-ChIP_CCG9911_Human1.06338802
134GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.06015021
135RING1B_27294783_Chip-Seq_ESCs_Mouse1.05162238
136NMYC_18555785_Chip-Seq_ESCs_Mouse1.05115692
137KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.04795177
138KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.04261560
139ERG_21242973_ChIP-ChIP_JURKAT_Human1.04248238
140TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse1.04069165
141Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.03914764
142SMAD4_21741376_ChIP-Seq_EPCs_Human1.03008036
143RUNX2_22187159_ChIP-Seq_PCA_Human1.02918000
144FOXM1_26456572_ChIP-Seq_MCF-7_Human1.02445014
145ER_23166858_ChIP-Seq_MCF-7_Human1.02180720
146TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.00345038
147BMI1_23680149_ChIP-Seq_NPCS_Mouse0.99295603
148EP300_21415370_ChIP-Seq_HL-1_Mouse0.97217648
149RING1B_27294783_Chip-Seq_NPCs_Mouse0.96522509
150SMAD3_21741376_ChIP-Seq_ESCs_Human0.96521025
151TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse0.96349497
152KDM2B_26808549_Chip-Seq_K562_Human0.93892487
153P53_22127205_ChIP-Seq_FIBROBLAST_Human0.93279795
154PRDM14_20953172_ChIP-Seq_ESCs_Human0.92967589
155TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.91365932
156TRIM28_17542650_ChIP-ChIP_NTERA2_Human0.90929437
157SMAD4_21741376_ChIP-Seq_HESCs_Human0.90902722
158NANOG_18555785_Chip-Seq_ESCs_Mouse0.90422676
159RNF2_27304074_Chip-Seq_NSC_Mouse0.89792791

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity5.60923574
2MP0003880_abnormal_central_pattern3.82640343
3MP0003635_abnormal_synaptic_transmissio3.71866532
4MP0003195_calcinosis3.57667331
5MP0004270_analgesia3.12163040
6MP0009046_muscle_twitch2.97863917
7MP0000569_abnormal_digit_pigmentation2.97224438
8MP0008877_abnormal_DNA_methylation2.92895655
9MP0005379_endocrine/exocrine_gland_phen2.92117993
10MP0002063_abnormal_learning/memory/cond2.91663114
11MP0009745_abnormal_behavioral_response2.90902318
12MP0002064_seizures2.89071878
13MP0009780_abnormal_chondrocyte_physiolo2.80929463
14MP0006072_abnormal_retinal_apoptosis2.79851481
15MP0001968_abnormal_touch/_nociception2.62014472
16MP0002572_abnormal_emotion/affect_behav2.43504655
17MP0008057_abnormal_DNA_replication2.36054956
18MP0003890_abnormal_embryonic-extraembry2.33201102
19MP0005423_abnormal_somatic_nervous2.31661123
20MP0002734_abnormal_mechanical_nocicepti2.31406691
21MP0002163_abnormal_gland_morphology2.31205796
22MP0001501_abnormal_sleep_pattern2.23748299
23MP0001486_abnormal_startle_reflex2.11687256
24MP0002909_abnormal_adrenal_gland2.03222621
25MP0006054_spinal_hemorrhage2.02981106
26MP0003122_maternal_imprinting2.02506633
27MP0006292_abnormal_olfactory_placode2.02288521
28MP0005253_abnormal_eye_physiology2.01590958
29MP0002272_abnormal_nervous_system1.97572767
30MP0002736_abnormal_nociception_after1.97088065
31MP0002735_abnormal_chemical_nociception1.94265966
32MP0002102_abnormal_ear_morphology1.93181902
33MP0010386_abnormal_urinary_bladder1.88340108
34MP0002733_abnormal_thermal_nociception1.85331581
35MP0003011_delayed_dark_adaptation1.82720067
36MP0001440_abnormal_grooming_behavior1.78600215
37MP0002067_abnormal_sensory_capabilities1.78371980
38MP0002938_white_spotting1.77050086
39MP0004133_heterotaxia1.76983118
40MP0004811_abnormal_neuron_physiology1.73888694
41MP0004858_abnormal_nervous_system1.72554138
42MP0001970_abnormal_pain_threshold1.72045518
43MP0003303_peritoneal_inflammation1.71994713
44MP0001944_abnormal_pancreas_morphology1.69613232
45MP0001529_abnormal_vocalization1.67971557
46MP0003690_abnormal_glial_cell1.65265580
47MP0000013_abnormal_adipose_tissue1.64536902
48MP0002184_abnormal_innervation1.64223179
49MP0005551_abnormal_eye_electrophysiolog1.63754922
50MP0000778_abnormal_nervous_system1.63243246
51MP0003123_paternal_imprinting1.62166950
52MP0006276_abnormal_autonomic_nervous1.60898452
53MP0002557_abnormal_social/conspecific_i1.59082282
54MP0003172_abnormal_lysosome_physiology1.58259068
55MP0005386_behavior/neurological_phenoty1.53732868
56MP0004924_abnormal_behavior1.53732868
57MP0005248_abnormal_Harderian_gland1.53651061
58MP0005646_abnormal_pituitary_gland1.52666148
59MP0008569_lethality_at_weaning1.52649410
60MP0003329_amyloid_beta_deposits1.46536897
61MP0005220_abnormal_exocrine_pancreas1.45847821
62MP0002693_abnormal_pancreas_physiology1.42795747
63MP0003787_abnormal_imprinting1.40535792
64MP0002822_catalepsy1.39243107
65MP0003633_abnormal_nervous_system1.38286402
66MP0000955_abnormal_spinal_cord1.36443942
67MP0004510_myositis1.32627786
68MP0002254_reproductive_system_inflammat1.29437078
69MP0000604_amyloidosis1.27618824
70MP0005645_abnormal_hypothalamus_physiol1.25741932
71MP0003183_abnormal_peptide_metabolism1.25173271
72MP0005167_abnormal_blood-brain_barrier1.23620355
73MP0002090_abnormal_vision1.19819327
74MP0001299_abnormal_eye_distance/1.18744304
75MP0002882_abnormal_neuron_morphology1.17042407
76MP0003879_abnormal_hair_cell1.16492539
77MP0005174_abnormal_tail_pigmentation1.16457619
78MP0002066_abnormal_motor_capabilities/c1.16257282
79MP0005623_abnormal_meninges_morphology1.16083370
80MP0008961_abnormal_basal_metabolism1.15380433
81MP0003634_abnormal_glial_cell1.14969807
82MP0003075_altered_response_to1.13365306
83MP0001502_abnormal_circadian_rhythm1.11200301
84MP0001984_abnormal_olfaction1.11001716
85MP0010234_abnormal_vibrissa_follicle1.10375403
86MP0001177_atelectasis1.07841268
87MP0003937_abnormal_limbs/digits/tail_de1.06183677
88MP0005084_abnormal_gallbladder_morpholo1.05955705
89MP0003631_nervous_system_phenotype1.02929628
90MP0002928_abnormal_bile_duct1.02485018
91MP0000427_abnormal_hair_cycle0.99930014
92MP0005391_vision/eye_phenotype0.99441226
93MP0004215_abnormal_myocardial_fiber0.98918254
94MP0003943_abnormal_hepatobiliary_system0.98635628
95MP0001485_abnormal_pinna_reflex0.98277651
96MP0005195_abnormal_posterior_eye0.97647067
97MP0005535_abnormal_body_temperature0.95459386
98MP0000372_irregular_coat_pigmentation0.95227781
99MP0001293_anophthalmia0.94152341
100MP0004130_abnormal_muscle_cell0.93490672
101MP0003567_abnormal_fetal_cardiomyocyte0.93362613
102MP0000647_abnormal_sebaceous_gland0.92794928
103MP0000639_abnormal_adrenal_gland0.92485721
104MP0008789_abnormal_olfactory_epithelium0.92178997
105MP0004885_abnormal_endolymph0.92100129
106MP0009697_abnormal_copulation0.90894951
107MP0008058_abnormal_DNA_repair0.90263066
108MP0000920_abnormal_myelination0.89903084
109MP0001324_abnormal_eye_pigmentation0.88515784
110MP0005187_abnormal_penis_morphology0.88321191
111MP0002152_abnormal_brain_morphology0.86264930
112MP0001188_hyperpigmentation0.85995054
113MP0002233_abnormal_nose_morphology0.85807547
114MP0000516_abnormal_urinary_system0.84385580
115MP0005367_renal/urinary_system_phenotyp0.84385580
116MP0005394_taste/olfaction_phenotype0.83950047
117MP0005499_abnormal_olfactory_system0.83950047
118MP0005058_abnormal_lysosome_morphology0.83849913
119MP0002078_abnormal_glucose_homeostasis0.83799227
120MP0001756_abnormal_urination0.78377754
121MP0003137_abnormal_impulse_conducting0.78273787
122MP0004742_abnormal_vestibular_system0.77635264
123MP0003045_fibrosis0.76997614
124MP0002069_abnormal_eating/drinking_beha0.75063771
125MP0002998_abnormal_bone_remodeling0.74368957
126MP0002229_neurodegeneration0.73388236
127MP0008874_decreased_physiological_sensi0.72794488
128MP0005389_reproductive_system_phenotype0.71641321
129MP0003283_abnormal_digestive_organ0.71092363
130MP0002837_dystrophic_cardiac_calcinosis0.69053724
131MP0005171_absent_coat_pigmentation0.68472369
132MP0005166_decreased_susceptibility_to0.68293576
133MP0004085_abnormal_heartbeat0.67415813
134MP0000751_myopathy0.66144609
135MP0003632_abnormal_nervous_system0.64922626
136MP0001905_abnormal_dopamine_level0.64285281
137MP0005503_abnormal_tendon_morphology0.64044381
138MP0003091_abnormal_cell_migration0.61665912
139MP0000631_abnormal_neuroendocrine_gland0.61017068
140MP0003300_gastrointestinal_ulcer0.60817487
141MP0004142_abnormal_muscle_tone0.59949813
142MP0004484_altered_response_of0.59391851
143MP0002876_abnormal_thyroid_physiology0.58690363
144MP0002638_abnormal_pupillary_reflex0.58292935
145MP0001943_abnormal_respiration0.57833980
146MP0004272_abnormal_basement_membrane0.56923228
147MP0001963_abnormal_hearing_physiology0.56600842
148MP0003121_genomic_imprinting0.54753349
149MP0002896_abnormal_bone_mineralization0.53768071
150MP0000015_abnormal_ear_pigmentation0.53304094
151MP0005409_darkened_coat_color0.51562438

Predicted human phenotypes

RankGene SetZ-score
1Focal motor seizures (HP:0011153)5.46982417
2Myokymia (HP:0002411)4.55305262
3Focal seizures (HP:0007359)4.51347250
4Visual hallucinations (HP:0002367)4.27687016
5Intestinal atresia (HP:0011100)4.21088472
6Atonic seizures (HP:0010819)3.89244423
7Pancreatic fibrosis (HP:0100732)3.85095009
8Action tremor (HP:0002345)3.83665499
9Progressive cerebellar ataxia (HP:0002073)3.56394255
10Absence seizures (HP:0002121)3.55646506
11True hermaphroditism (HP:0010459)3.41719028
12Supranuclear gaze palsy (HP:0000605)3.41694102
13Papilledema (HP:0001085)3.34854087
14Medial flaring of the eyebrow (HP:0010747)3.34345490
15Febrile seizures (HP:0002373)3.30910541
16Dialeptic seizures (HP:0011146)3.21687762
17Pancreatic cysts (HP:0001737)3.20188467
18Generalized tonic-clonic seizures (HP:0002069)3.19347847
19Epileptic encephalopathy (HP:0200134)3.16500293
20Nephronophthisis (HP:0000090)3.08802057
21Macroorchidism (HP:0000053)3.06505012
22Hyperinsulinemic hypoglycemia (HP:0000825)3.04610289
23Hypoglycemic seizures (HP:0002173)3.00004920
24Mutism (HP:0002300)2.99210164
25Molar tooth sign on MRI (HP:0002419)2.87049177
26Abnormality of midbrain morphology (HP:0002418)2.87049177
27Double outlet right ventricle (HP:0001719)2.85741150
28Congenital malformation of the right heart (HP:0011723)2.85741150
29Depression (HP:0000716)2.85145502
30Type II lissencephaly (HP:0007260)2.82050046
31Agitation (HP:0000713)2.80855653
32Hypothermia (HP:0002045)2.80481541
33Congenital primary aphakia (HP:0007707)2.77493970
34Gait imbalance (HP:0002141)2.76035497
35Abnormality of vitamin B metabolism (HP:0004340)2.70209346
36Truncal ataxia (HP:0002078)2.69997492
37Hypoglycemic coma (HP:0001325)2.68786128
38Inappropriate behavior (HP:0000719)2.59993935
39Increased cerebral lipofuscin (HP:0011813)2.56931996
40Ankle clonus (HP:0011448)2.54818948
41Broad-based gait (HP:0002136)2.53464827
42Genital tract atresia (HP:0001827)2.52881728
43Excessive salivation (HP:0003781)2.52151453
44Drooling (HP:0002307)2.52151453
45Poor eye contact (HP:0000817)2.50596740
46Cerebellar dysplasia (HP:0007033)2.50545309
47Abnormality of the renal medulla (HP:0100957)2.49680966
48Abnormal eating behavior (HP:0100738)2.48278340
49Gastrointestinal atresia (HP:0002589)2.46797098
50Amblyopia (HP:0000646)2.42822508
51Volvulus (HP:0002580)2.42184087
52Methylmalonic acidemia (HP:0002912)2.42106700
53Nephrogenic diabetes insipidus (HP:0009806)2.40730751
54Abnormality of aromatic amino acid family metabolism (HP:0004338)2.39991407
55Termporal pattern (HP:0011008)2.39823234
56Insidious onset (HP:0003587)2.39823234
57Impaired social interactions (HP:0000735)2.39289415
58Abnormal social behavior (HP:0012433)2.39289415
59Urinary bladder sphincter dysfunction (HP:0002839)2.38250457
60Hyperglycemia (HP:0003074)2.37724863
61Elevated circulating parathyroid hormone (PTH) level (HP:0003165)2.37454252
62Sclerocornea (HP:0000647)2.37442835
63Oligodactyly (hands) (HP:0001180)2.35726998
64Ketoacidosis (HP:0001993)2.33375016
65Aplasia/Hypoplasia of the tibia (HP:0005772)2.32401301
66Disinhibition (HP:0000734)2.31201145
67Postural instability (HP:0002172)2.31009647
68Neuronal loss in central nervous system (HP:0002529)2.30796220
69Vaginal atresia (HP:0000148)2.30062826
70Impaired vibration sensation in the lower limbs (HP:0002166)2.29805251
71Genetic anticipation (HP:0003743)2.28205559
72Aqueductal stenosis (HP:0002410)2.27659929
73Neurofibrillary tangles (HP:0002185)2.27388789
74Torticollis (HP:0000473)2.25640262
75Anxiety (HP:0000739)2.25394923
76Urinary urgency (HP:0000012)2.25187846
77Progressive macrocephaly (HP:0004481)2.25139866
78Poor coordination (HP:0002370)2.23812202
79Dysmetria (HP:0001310)2.23388415
80Cerebral inclusion bodies (HP:0100314)2.22859921
81Dysdiadochokinesis (HP:0002075)2.22458267
82Large for gestational age (HP:0001520)2.21469273
83Pheochromocytoma (HP:0002666)2.20811076
84Postural tremor (HP:0002174)2.20181135
85Aplasia/Hypoplasia of the tongue (HP:0010295)2.20040749
86Polyphagia (HP:0002591)2.18763536
87Pancreatic islet-cell hyperplasia (HP:0004510)2.18644437
88Limb dystonia (HP:0002451)2.18481487
89Progressive inability to walk (HP:0002505)2.15904088
90Chronic hepatic failure (HP:0100626)2.15308976
91Gaze-evoked nystagmus (HP:0000640)2.13792294
92Acute necrotizing encephalopathy (HP:0006965)2.11132228
93Hyperventilation (HP:0002883)2.10246208
94Anencephaly (HP:0002323)2.09160462
95Menstrual irregularities (HP:0000858)2.08996111
96Hypoventilation (HP:0002791)2.07909617
97Resting tremor (HP:0002322)2.07812302
98Abnormality of the renal cortex (HP:0011035)2.06532762
99Exotropia (HP:0000577)2.05681590
100Cystic liver disease (HP:0006706)2.04322617
101Abnormality of binocular vision (HP:0011514)2.03996843
102Diplopia (HP:0000651)2.03996843
103Abnormality of vitamin metabolism (HP:0100508)2.02136611
104Arterial tortuosity (HP:0005116)2.02106647
105Short tibia (HP:0005736)2.02020435
106Blue irides (HP:0000635)2.01804144
107Stereotypic behavior (HP:0000733)1.99971037
108Abdominal situs inversus (HP:0003363)1.99217338
109Abnormality of abdominal situs (HP:0011620)1.99217338
110Poor suck (HP:0002033)1.98350342
111Epileptiform EEG discharges (HP:0011182)1.95775174
112Intention tremor (HP:0002080)1.95476542
113Abnormality of the metopic suture (HP:0005556)1.93844128
114Failure to thrive in infancy (HP:0001531)1.93784344
115Postaxial foot polydactyly (HP:0001830)1.93451450
116Apathy (HP:0000741)1.93007202
117Abnormality of the pancreatic islet cells (HP:0006476)1.92366005
118Abnormality of endocrine pancreas physiology (HP:0012093)1.92366005
119EEG with generalized epileptiform discharges (HP:0011198)1.92248594
120Neuroendocrine neoplasm (HP:0100634)1.91818031
121Specific learning disability (HP:0001328)1.90869442
122Enlarged penis (HP:0000040)1.90762236
123Hemiparesis (HP:0001269)1.90050151
124Focal dystonia (HP:0004373)1.89834015
125Bifid tongue (HP:0010297)1.89486972
126Disproportionate short-trunk short stature (HP:0003521)1.89112748
127Impaired smooth pursuit (HP:0007772)1.88945739
128Lower limb muscle weakness (HP:0007340)1.88128238
129Absent frontal sinuses (HP:0002688)1.87923686
130Anophthalmia (HP:0000528)1.87815478
131Vascular tortuosity (HP:0004948)1.86633710
132Hypsarrhythmia (HP:0002521)1.86585891
133Lower limb asymmetry (HP:0100559)1.86527744
134Scanning speech (HP:0002168)1.86376482
135Absent speech (HP:0001344)1.86320382
136Increased neuronal autofluorescent lipopigment (HP:0002074)1.86121827
137Abnormality of the fovea (HP:0000493)1.85977931
138Hemiplegia (HP:0002301)1.85396459
139Megalencephaly (HP:0001355)1.85079084
140Dysostosis multiplex (HP:0000943)1.84911147
141Hypoplasia of the fovea (HP:0007750)1.84210788
142Aplasia/Hypoplasia of the fovea (HP:0008060)1.84210788
143Muscular hypotonia of the trunk (HP:0008936)1.83832241
144Postaxial hand polydactyly (HP:0001162)1.83629588
145Symptomatic seizures (HP:0011145)1.83591591
146Prominent metopic ridge (HP:0005487)1.83161503
147Hyperthyroidism (HP:0000836)1.82600861
148Bradykinesia (HP:0002067)1.82317013
149Congenital stationary night blindness (HP:0007642)1.81855702
150Male pseudohermaphroditism (HP:0000037)1.80508992
151Abnormality of chromosome stability (HP:0003220)1.80112513
152Lower limb amyotrophy (HP:0007210)1.79656413
153Abnormality of ocular smooth pursuit (HP:0000617)1.79455767
154Abnormality of salivation (HP:0100755)1.79339410
155Narrow forehead (HP:0000341)1.78917616
156Supernumerary spleens (HP:0009799)1.78547315
157Abnormal pancreas size (HP:0012094)1.78502238
158Labial hypoplasia (HP:0000066)1.77707552
159Furrowed tongue (HP:0000221)1.77583469
160Abolished electroretinogram (ERG) (HP:0000550)1.76100672
161Downturned corners of mouth (HP:0002714)1.75200605
162Rapidly progressive (HP:0003678)1.74736153
163Methylmalonic aciduria (HP:0012120)1.74420529
164Spastic gait (HP:0002064)1.73214898
165Preaxial hand polydactyly (HP:0001177)1.72802674
166Akinesia (HP:0002304)1.72412420
167Status epilepticus (HP:0002133)1.71727253
168Abnormal sex determination (HP:0012244)1.71416028
169Sex reversal (HP:0012245)1.71416028
170Diminished motivation (HP:0000745)1.70418485
171Craniofacial dystonia (HP:0012179)1.70013476
172Septo-optic dysplasia (HP:0100842)1.67351510
173Hypercortisolism (HP:0001578)1.67159339
174Acute encephalopathy (HP:0006846)1.66424507
175Ankyloglossia (HP:0010296)1.65749285
176Buphthalmos (HP:0000557)1.65676186
177J-shaped sella turcica (HP:0002680)1.65312135
178Gait ataxia (HP:0002066)1.65311008
179Spinal canal stenosis (HP:0003416)1.65264592
180Oligodactyly (HP:0012165)1.65230820
181Broad foot (HP:0001769)1.65184332
182Hypoplastic female external genitalia (HP:0012815)1.64604004
183Abnormal biliary tract physiology (HP:0012439)1.64021503
184Bile duct proliferation (HP:0001408)1.64021503

Predicted kinase interactions (KEA)

RankGene SetZ-score
1NTRK34.17869675
2MAP3K93.76196276
3MARK13.13904406
4WNK32.94071509
5RIPK42.77209138
6MAP3K42.75866688
7EPHA42.67571298
8MINK12.52893697
9MAP3K122.25394953
10MKNK22.24976122
11PINK12.20208704
12BMPR1B2.19906688
13DAPK22.18017147
14MAP2K72.09651787
15MAP4K22.04665146
16TRIM282.04237012
17NTRK11.95767076
18KSR21.90568371
19CAMKK11.88217900
20NTRK21.87530034
21STK38L1.85923269
22PAK61.85650144
23MAP2K41.83286061
24CASK1.82159603
25MKNK11.67200159
26STK31.65564034
27ZAK1.65415249
28RIPK11.61900801
29PLK21.61440011
30CSNK1G11.59581198
31KSR11.58207866
32SIK21.58081945
33PNCK1.57209714
34MAP3K21.56374718
35CAMKK21.54382058
36FRK1.48450321
37PRKD31.44912808
38BRSK21.41209037
39PRKCH1.40111561
40CDK51.39352353
41ADRBK21.38716714
42PLK31.36478437
43NLK1.35878018
44GRK51.35781267
45GRK11.33898159
46RET1.33170282
47ERBB31.32713314
48CSNK1G31.30330867
49STK241.29676609
50FES1.20726620
51INSRR1.18868454
52ACVR1B1.18065522
53MST41.15657023
54MAPK131.14152355
55EIF2AK31.11896289
56DAPK11.11733313
57DYRK31.04873813
58IRAK11.01595234
59CSNK1A1L0.95267629
60STK390.94126473
61CAMK1G0.93881996
62UHMK10.92425408
63SGK30.91796810
64PRKCG0.91620300
65SCYL20.88598001
66DDR20.87173719
67ARAF0.87103966
68RPS6KA20.86819784
69MAP3K130.86351666
70EIF2AK10.84764968
71PDGFRA0.84527941
72NUAK10.83716470
73STK380.83621299
74PRPF4B0.83256835
75FGFR20.82501880
76YES10.82241309
77PAK30.82110008
78LIMK10.81417603
79SRPK10.79927955
80PLK40.79825234
81SGK20.79360055
82WNK40.79045235
83TYRO30.78935990
84STK110.78840094
85STK100.77596617
86FGR0.76618742
87LATS10.76157699
88CAMK2A0.75461051
89PDK10.75397234
90BMPR20.74177960
91CSNK1G20.73269940
92PHKG10.72790999
93PHKG20.72790999
94TAF10.72262490
95EPHA30.72187910
96TNIK0.72132552
97MAP3K10.71354017
98FER0.69813806
99DYRK20.69499667
100SGK2230.69398159
101SGK4940.69398159
102PDPK10.67370492
103PRKCE0.66972196
104PASK0.66731664
105IRAK20.66699242
106FYN0.65306925
107SGK10.64584331
108AKT30.63195062
109CDK140.62298589
110PTK2B0.61470303
111ATM0.60893530
112PLK10.60701514
113FGFR10.59922113
114PDGFRB0.58854734
115CDK180.58758557
116WNK10.58359983
117STK160.58040981
118SIK30.56908212
119DMPK0.56133846
120MARK30.56125278
121CSNK1E0.55652659
122CDK150.54824682
123TRIB30.53723201
124CDC42BPA0.53483458
125JAK10.52857484
126CAMK2D0.52374905
127CSNK1A10.51918694
128EPHB20.50963509
129LATS20.50812894
130MAP3K50.50347169
131ADRBK10.50098811
132PRKCZ0.49365297
133MAP2K60.49325691
134MAP2K10.48444864
135CAMK2B0.48047957
136TTK0.47666209
137CAMK1D0.47083545
138FGFR30.46679600
139BMX0.46592059
140RPS6KA30.46171085
141PRKACB0.44606568
142DYRK1A0.44597235
143FLT30.43742457
144CSNK1D0.43371145
145MAPK100.42545222
146CDK11A0.42339503
147GSK3A0.41849510
148RAF10.41187411
149CAMK10.41032945
150MAP3K60.40826399
151TAOK10.40174548
152ROCK10.39071295
153BCR0.37069912
154SRC0.36713068
155LMTK20.36585393
156WEE10.36310108
157OXSR10.35663241
158TSSK60.35114677
159EGFR0.34964535
160BRD40.33804485
161PRKG10.33390350
162BUB10.33278747

Predicted pathways (KEGG)

RankGene SetZ-score
1Protein export_Homo sapiens_hsa030604.11411202
2Maturity onset diabetes of the young_Homo sapiens_hsa049503.60523837
3Synthesis and degradation of ketone bodies_Homo sapiens_hsa000723.19113754
4Synaptic vesicle cycle_Homo sapiens_hsa047212.84962138
5Folate biosynthesis_Homo sapiens_hsa007902.66324370
6Selenocompound metabolism_Homo sapiens_hsa004502.59003069
7Nicotine addiction_Homo sapiens_hsa050332.58770706
8Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005632.37020517
9Vitamin B6 metabolism_Homo sapiens_hsa007502.20982879
10Butanoate metabolism_Homo sapiens_hsa006502.17288272
11GABAergic synapse_Homo sapiens_hsa047272.13872529
12Olfactory transduction_Homo sapiens_hsa047402.11639825
13Circadian entrainment_Homo sapiens_hsa047132.08922815
14Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.02934743
15Morphine addiction_Homo sapiens_hsa050322.01483077
16Long-term potentiation_Homo sapiens_hsa047201.96604590
17Glutamatergic synapse_Homo sapiens_hsa047241.87122192
18Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.86057597
19Sulfur metabolism_Homo sapiens_hsa009201.78593650
20Oxidative phosphorylation_Homo sapiens_hsa001901.77907655
21Dopaminergic synapse_Homo sapiens_hsa047281.77440049
22Insulin secretion_Homo sapiens_hsa049111.77194100
23Homologous recombination_Homo sapiens_hsa034401.77054666
24Amphetamine addiction_Homo sapiens_hsa050311.76960044
25Non-homologous end-joining_Homo sapiens_hsa034501.68880240
26Fanconi anemia pathway_Homo sapiens_hsa034601.67560178
27Collecting duct acid secretion_Homo sapiens_hsa049661.66847272
28Cholinergic synapse_Homo sapiens_hsa047251.64190916
29Salivary secretion_Homo sapiens_hsa049701.60404540
30Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.58480760
31Propanoate metabolism_Homo sapiens_hsa006401.53374743
32Phototransduction_Homo sapiens_hsa047441.53099200
33Aldosterone synthesis and secretion_Homo sapiens_hsa049251.51144588
34Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.51140824
35Cocaine addiction_Homo sapiens_hsa050301.51004636
36Renin secretion_Homo sapiens_hsa049241.50610214
37Basal transcription factors_Homo sapiens_hsa030221.49686139
38Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.49292274
39Circadian rhythm_Homo sapiens_hsa047101.48696227
40Gastric acid secretion_Homo sapiens_hsa049711.48290567
41Type II diabetes mellitus_Homo sapiens_hsa049301.44408949
42Vibrio cholerae infection_Homo sapiens_hsa051101.36730640
43RNA degradation_Homo sapiens_hsa030181.36656150
44Long-term depression_Homo sapiens_hsa047301.35883717
45Serotonergic synapse_Homo sapiens_hsa047261.35298255
46Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.33410049
47Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.32352923
48Oxytocin signaling pathway_Homo sapiens_hsa049211.28932834
49GnRH signaling pathway_Homo sapiens_hsa049121.28805428
50Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.24772070
51Taste transduction_Homo sapiens_hsa047421.21183631
52Sphingolipid metabolism_Homo sapiens_hsa006001.21168126
53Glioma_Homo sapiens_hsa052141.19481524
54Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.19133752
55Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051201.17498600
56Mismatch repair_Homo sapiens_hsa034301.16942537
57Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.16745480
58Estrogen signaling pathway_Homo sapiens_hsa049151.16470348
59Parkinsons disease_Homo sapiens_hsa050121.16206162
60Regulation of lipolysis in adipocytes_Homo sapiens_hsa049231.13069712
61cAMP signaling pathway_Homo sapiens_hsa040241.11641154
62Regulation of autophagy_Homo sapiens_hsa041401.11110719
63Calcium signaling pathway_Homo sapiens_hsa040201.10612269
64Gap junction_Homo sapiens_hsa045401.09850519
65Steroid biosynthesis_Homo sapiens_hsa001001.08641257
66Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.08086211
67Dorso-ventral axis formation_Homo sapiens_hsa043201.03855646
68Peroxisome_Homo sapiens_hsa041461.02956732
69Axon guidance_Homo sapiens_hsa043601.01903899
70Type I diabetes mellitus_Homo sapiens_hsa049401.00767736
71Rheumatoid arthritis_Homo sapiens_hsa053230.97737343
72Phosphatidylinositol signaling system_Homo sapiens_hsa040700.96609092
73One carbon pool by folate_Homo sapiens_hsa006700.96019750
74ErbB signaling pathway_Homo sapiens_hsa040120.95024936
75Neurotrophin signaling pathway_Homo sapiens_hsa047220.94787825
76Phagosome_Homo sapiens_hsa041450.92622054
77Primary bile acid biosynthesis_Homo sapiens_hsa001200.92137366
78cGMP-PKG signaling pathway_Homo sapiens_hsa040220.91745193
79Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.91730799
80Ether lipid metabolism_Homo sapiens_hsa005650.89566333
81Tryptophan metabolism_Homo sapiens_hsa003800.89136760
82Huntingtons disease_Homo sapiens_hsa050160.87710060
83Melanogenesis_Homo sapiens_hsa049160.85451071
84RNA polymerase_Homo sapiens_hsa030200.84632363
85Hedgehog signaling pathway_Homo sapiens_hsa043400.84380283
86Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.82613614
87Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.82226419
88Lysosome_Homo sapiens_hsa041420.81888022
89Phospholipase D signaling pathway_Homo sapiens_hsa040720.81818640
90Thyroid hormone synthesis_Homo sapiens_hsa049180.81218265
91Vascular smooth muscle contraction_Homo sapiens_hsa042700.80662319
92Alzheimers disease_Homo sapiens_hsa050100.78891929
93Fatty acid elongation_Homo sapiens_hsa000620.78309779
94Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.77420834
95Carbohydrate digestion and absorption_Homo sapiens_hsa049730.75378017
96Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.74958000
97Tuberculosis_Homo sapiens_hsa051520.74908100
98Purine metabolism_Homo sapiens_hsa002300.74799308
99Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.74731545
100Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.74049387
101Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.73675687
102MAPK signaling pathway_Homo sapiens_hsa040100.73455998
103Glutathione metabolism_Homo sapiens_hsa004800.73446150
104Nucleotide excision repair_Homo sapiens_hsa034200.72766460
105Osteoclast differentiation_Homo sapiens_hsa043800.72252357
106Dilated cardiomyopathy_Homo sapiens_hsa054140.71149399
107mTOR signaling pathway_Homo sapiens_hsa041500.69457396
108Sphingolipid signaling pathway_Homo sapiens_hsa040710.69183223
109Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.69090902
110Renal cell carcinoma_Homo sapiens_hsa052110.67686780
111Chemokine signaling pathway_Homo sapiens_hsa040620.67479890
112TGF-beta signaling pathway_Homo sapiens_hsa043500.67142577
113Glycosaminoglycan degradation_Homo sapiens_hsa005310.66323086
114Prion diseases_Homo sapiens_hsa050200.65284356
115Endocytosis_Homo sapiens_hsa041440.65092417
116Salmonella infection_Homo sapiens_hsa051320.64520118
117VEGF signaling pathway_Homo sapiens_hsa043700.63478830
118Endometrial cancer_Homo sapiens_hsa052130.63418620
119Glucagon signaling pathway_Homo sapiens_hsa049220.62673366
120Nitrogen metabolism_Homo sapiens_hsa009100.62486025
121beta-Alanine metabolism_Homo sapiens_hsa004100.61538282
122Prolactin signaling pathway_Homo sapiens_hsa049170.60854949
123SNARE interactions in vesicular transport_Homo sapiens_hsa041300.60515422
124Hippo signaling pathway_Homo sapiens_hsa043900.59754705
125Rap1 signaling pathway_Homo sapiens_hsa040150.59710595
126Pancreatic secretion_Homo sapiens_hsa049720.59481983
127AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.59035630
128Amoebiasis_Homo sapiens_hsa051460.58642524
129Choline metabolism in cancer_Homo sapiens_hsa052310.58476043
130Metabolic pathways_Homo sapiens_hsa011000.58255086
131Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.58207286
132Platelet activation_Homo sapiens_hsa046110.57766654
133Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.56785358
134Ras signaling pathway_Homo sapiens_hsa040140.56740279
135RNA transport_Homo sapiens_hsa030130.54899619
136Toll-like receptor signaling pathway_Homo sapiens_hsa046200.54709927
137African trypanosomiasis_Homo sapiens_hsa051430.53686411
138Cysteine and methionine metabolism_Homo sapiens_hsa002700.51988383
139Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.51857574
140Thyroid hormone signaling pathway_Homo sapiens_hsa049190.51682120
141Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.50500829
142Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.50084613
143Non-small cell lung cancer_Homo sapiens_hsa052230.49038988
144Colorectal cancer_Homo sapiens_hsa052100.48680226
145Oocyte meiosis_Homo sapiens_hsa041140.48635720
146Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.48512817
147Focal adhesion_Homo sapiens_hsa045100.48240112
148Ovarian steroidogenesis_Homo sapiens_hsa049130.48173294
149Longevity regulating pathway - mammal_Homo sapiens_hsa042110.47957577
150Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.47383820
151Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.47355414
152Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.46264848
153Insulin signaling pathway_Homo sapiens_hsa049100.45714373
154TNF signaling pathway_Homo sapiens_hsa046680.45366864
155Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.45129972
156Fatty acid metabolism_Homo sapiens_hsa012120.44547199
157Cardiac muscle contraction_Homo sapiens_hsa042600.42389305
158mRNA surveillance pathway_Homo sapiens_hsa030150.40593668
159Wnt signaling pathway_Homo sapiens_hsa043100.39995179
160Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.38338114
161Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.32379486
162Inositol phosphate metabolism_Homo sapiens_hsa005620.32071981
163Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.31251649
164Basal cell carcinoma_Homo sapiens_hsa052170.30450028

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