SLC37A1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene localizes to the endoplasmic reticulum (ER) membrane. This protein translocates glucose-6-phosphate from the cytoplasm into the lumen of the ER for hydrolysis into glucose by another ER membrane protein. This gene is a member of the solute carrier 37 gene family. Alternative splicing results in multiple transcript variants. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1Golgi transport vesicle coating (GO:0048200)6.90358769
2COPI coating of Golgi vesicle (GO:0048205)6.90358769
3antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)5.56905747
4antigen processing and presentation of endogenous peptide antigen (GO:0002483)5.56905747
5UDP-N-acetylglucosamine metabolic process (GO:0006047)4.78222708
6antigen processing and presentation of endogenous antigen (GO:0019883)4.73888801
7glucose 6-phosphate metabolic process (GO:0051156)4.54790953
8retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)4.37831426
9maintenance of protein localization in endoplasmic reticulum (GO:0035437)4.35921071
10cellular response to interferon-beta (GO:0035458)4.35003521
11thrombin receptor signaling pathway (GO:0070493)4.29084716
12axonemal dynein complex assembly (GO:0070286)4.25091090
13intestinal epithelial cell development (GO:0060576)4.22914560
14negative regulation of glycoprotein biosynthetic process (GO:0010561)3.96359130
15GDP-mannose metabolic process (GO:0019673)3.93385477
16antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G3.87268669
17protein retention in ER lumen (GO:0006621)3.81336915
18regulation of gamma-delta T cell differentiation (GO:0045586)3.80969717
19COPII vesicle coating (GO:0048208)3.79033100
20endocrine pancreas development (GO:0031018)3.76816925
21antigen processing and presentation via MHC class Ib (GO:0002475)3.74810610
22glandular epithelial cell differentiation (GO:0002067)3.73894696
23intestinal absorption (GO:0050892)3.71655695
24immunoglobulin mediated immune response (GO:0016064)3.67857196
25phospholipase C-activating dopamine receptor signaling pathway (GO:0060158)3.67211836
26leukotriene biosynthetic process (GO:0019370)3.65705191
27cilium or flagellum-dependent cell motility (GO:0001539)3.63996234
28negative regulation of bone resorption (GO:0045779)3.55646290
29neutrophil activation involved in immune response (GO:0002283)3.52641487
30peptide hormone processing (GO:0016486)3.49925397
31SRP-dependent cotranslational protein targeting to membrane (GO:0006614)3.45775614
32positive regulation of gamma-delta T cell activation (GO:0046645)3.43448649
33negative regulation of erythrocyte differentiation (GO:0045647)3.40363744
34activation of signaling protein activity involved in unfolded protein response (GO:0006987)3.36002296
35protein targeting to ER (GO:0045047)3.35053100
36cotranslational protein targeting to membrane (GO:0006613)3.30682023
37signal peptide processing (GO:0006465)3.29847695
38response to interferon-beta (GO:0035456)3.29602885
39positive regulation of nuclease activity (GO:0032075)3.27422966
40regulation of gamma-delta T cell activation (GO:0046643)3.23662952
41establishment of protein localization to endoplasmic reticulum (GO:0072599)3.19856047
42L-alpha-amino acid transmembrane transport (GO:1902475)3.18269822
43sequestering of metal ion (GO:0051238)3.17660564
44protein localization to endoplasmic reticulum (GO:0070972)3.17380694
45B cell receptor signaling pathway (GO:0050853)3.17179661
46protein maturation by protein folding (GO:0022417)3.16074617
47maintenance of gastrointestinal epithelium (GO:0030277)3.10316715
48lipoxygenase pathway (GO:0019372)3.08180206
49response to peptidoglycan (GO:0032494)3.08035769
50motile cilium assembly (GO:0044458)3.06913350
51definitive hemopoiesis (GO:0060216)3.06809594
52regulation of nuclease activity (GO:0032069)3.06441441
53pyrimidine-containing compound salvage (GO:0008655)3.04931356
54pyrimidine nucleoside salvage (GO:0043097)3.04931356
55ribosomal small subunit assembly (GO:0000028)3.03107036
56endoplasmic reticulum unfolded protein response (GO:0030968)3.03027184
57intestinal cholesterol absorption (GO:0030299)3.01804653
58positive regulation of insulin secretion (GO:0032024)3.01307518
593-phosphoadenosine 5-phosphosulfate metabolic process (GO:0050427)2.97701959
60purine ribonucleoside bisphosphate metabolic process (GO:0034035)2.97701959
61cellular response to unfolded protein (GO:0034620)2.96493461
62nucleotide-sugar biosynthetic process (GO:0009226)2.95834072
63cilium movement (GO:0003341)2.95321664
64peptide catabolic process (GO:0043171)2.94611317
65nucleotide salvage (GO:0043173)2.93324915
66B cell mediated immunity (GO:0019724)2.91163541
67positive regulation of insulin secretion involved in cellular response to glucose stimulus (GO:003572.86516626
68cellular response to topologically incorrect protein (GO:0035967)2.86396956
69negative regulation of glycoprotein metabolic process (GO:1903019)2.84225292
70adaptation of signaling pathway (GO:0023058)2.84115620
71regulation of integrin activation (GO:0033623)2.83301925
72angiotensin maturation (GO:0002003)2.82815833
73growth hormone receptor signaling pathway (GO:0060396)2.82607745
74viral transcription (GO:0019083)2.79835227
75regulation of dendritic cell antigen processing and presentation (GO:0002604)2.79059507
76positive regulation of type 2 immune response (GO:0002830)2.78224033
77vesicle coating (GO:0006901)2.77328996
78detection of bacterium (GO:0016045)2.77124240
79interferon-gamma-mediated signaling pathway (GO:0060333)2.76971120
80germinal center formation (GO:0002467)2.76907450
81regulation of cellular extravasation (GO:0002691)2.75966613
82columnar/cuboidal epithelial cell development (GO:0002066)2.75778113
83regulation of respiratory burst (GO:0060263)2.73732534
84positive regulation of B cell differentiation (GO:0045579)2.73004639
85regulation of RIG-I signaling pathway (GO:0039535)2.71925383
86negative regulation of lipopolysaccharide-mediated signaling pathway (GO:0031665)2.71556100
87regulation of mast cell degranulation (GO:0043304)2.69910977
88negative regulation of cell killing (GO:0031342)2.69555858
89negative regulation of leukocyte mediated cytotoxicity (GO:0001911)2.69555858
90intra-Golgi vesicle-mediated transport (GO:0006891)2.69429629
91positive thymic T cell selection (GO:0045059)2.69314304
92translational termination (GO:0006415)2.68878001
93protein autoprocessing (GO:0016540)2.68826258
94JAK-STAT cascade involved in growth hormone signaling pathway (GO:0060397)2.68274167
95positive regulation by symbiont of host defense response (GO:0052509)2.67739100
96modulation by symbiont of host defense response (GO:0052031)2.67739100
97modulation by organism of immune response of other organism involved in symbiotic interaction (GO:002.67739100
98modulation by organism of defense response of other organism involved in symbiotic interaction (GO:02.67739100
99positive regulation by organism of defense response of other organism involved in symbiotic interact2.67739100
100modulation by symbiont of host immune response (GO:0052553)2.67739100
101regulation of antigen processing and presentation of peptide antigen (GO:0002583)2.67545825
102regulation of interleukin-12 biosynthetic process (GO:0045075)2.67434310
103chaperone mediated protein folding requiring cofactor (GO:0051085)2.66765341
104ER-nucleus signaling pathway (GO:0006984)2.66642864
105response to type I interferon (GO:0034340)2.65994881
106bundle of His cell to Purkinje myocyte communication (GO:0086069)2.65670337
107response to host immune response (GO:0052572)2.65258321
108response to immune response of other organism involved in symbiotic interaction (GO:0052564)2.65258321
109positive regulation of antigen processing and presentation (GO:0002579)2.65065218
110protein N-linked glycosylation via asparagine (GO:0018279)2.64389889
111amyloid precursor protein catabolic process (GO:0042987)2.64296912
112nucleotide-sugar metabolic process (GO:0009225)2.64294430
113negative regulation of granulocyte differentiation (GO:0030853)2.64173893
114peptidyl-asparagine modification (GO:0018196)2.62743817
115hepatocyte apoptotic process (GO:0097284)2.62385659
116type I interferon signaling pathway (GO:0060337)2.62288955
117cellular response to type I interferon (GO:0071357)2.62288955
118negative regulation of bone remodeling (GO:0046851)2.62278070
119positive regulation of Cdc42 GTPase activity (GO:0043089)2.60845579
120regulation of leukocyte degranulation (GO:0043300)2.59931920
121epithelial structure maintenance (GO:0010669)2.59919557
122pyrimidine ribonucleoside monophosphate metabolic process (GO:0009173)2.59141718
123UMP biosynthetic process (GO:0006222)2.59141718
124pyrimidine ribonucleoside monophosphate biosynthetic process (GO:0009174)2.59141718
125UMP metabolic process (GO:0046049)2.59141718
126sperm motility (GO:0030317)2.58628889
127regulation of B cell receptor signaling pathway (GO:0050855)2.58272843
128regulation of antigen processing and presentation (GO:0002577)2.58196235
129detection of other organism (GO:0098543)2.57923228
130Arp2/3 complex-mediated actin nucleation (GO:0034314)2.57896865
131trophectodermal cell differentiation (GO:0001829)2.57190865
132carbohydrate phosphorylation (GO:0046835)2.56847481
133ER-associated ubiquitin-dependent protein catabolic process (GO:0030433)2.56541447
134epithelial cilium movement (GO:0003351)2.54931294
135cellular zinc ion homeostasis (GO:0006882)2.53652683
136regulation of myeloid leukocyte mediated immunity (GO:0002886)2.52787666
137positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)2.52440566
138regulation of cholesterol homeostasis (GO:2000188)2.51252162
139positive regulation of peptide hormone secretion (GO:0090277)2.50799018
140antimicrobial humoral response (GO:0019730)2.50705575
141neutrophil activation (GO:0042119)2.50093915
142regulation of interleukin-13 production (GO:0032656)2.49137279
143phospholipid scrambling (GO:0017121)2.48840890
144sexual reproduction (GO:0019953)2.47404272
145antibacterial humoral response (GO:0019731)2.47225204
146translational elongation (GO:0006414)2.46548854
147N-acetylneuraminate metabolic process (GO:0006054)2.46261025
148regulation of mast cell activation involved in immune response (GO:0033006)2.46085802
149nucleoside salvage (GO:0043174)2.46033158
150sperm capacitation (GO:0048240)2.44787786
151regulation of interferon-beta biosynthetic process (GO:0045357)2.44388288
152regulation of germinal center formation (GO:0002634)2.42594793
153mature B cell differentiation involved in immune response (GO:0002313)2.41927828
154cellular response to exogenous dsRNA (GO:0071360)2.41207610
155GMP metabolic process (GO:0046037)2.40221840
156peptidyl-tyrosine autophosphorylation (GO:0038083)2.39675674
157response to endoplasmic reticulum stress (GO:0034976)2.37514667
158viral life cycle (GO:0019058)2.37277220
159ER to Golgi vesicle-mediated transport (GO:0006888)2.36417098
160protein N-linked glycosylation (GO:0006487)2.34988615
161leukotriene metabolic process (GO:0006691)2.34946198
162receptor recycling (GO:0001881)2.34826749
163cellular response to growth hormone stimulus (GO:0071378)2.34795464
164response to host (GO:0075136)2.34197852
165response to host defenses (GO:0052200)2.34197852
166response to defenses of other organism involved in symbiotic interaction (GO:0052173)2.34197852
167response to muramyl dipeptide (GO:0032495)2.32175003
168defense response to protozoan (GO:0042832)2.31990298
169regulation of systemic arterial blood pressure by renin-angiotensin (GO:0003081)2.31656228
170actin nucleation (GO:0045010)2.30835700
171regulation of interleukin-4 production (GO:0032673)2.30350182
172histone H3-K36 demethylation (GO:0070544)2.29472241
173axoneme assembly (GO:0035082)2.27762427
174B cell homeostasis (GO:0001782)2.27437088
175regulation of regulated secretory pathway (GO:1903305)2.26387286
176response to protozoan (GO:0001562)2.25802386
177regulation of guanylate cyclase activity (GO:0031282)2.25332178
178mucosal-associated lymphoid tissue development (GO:0048537)2.23269839
179Peyers patch development (GO:0048541)2.23269839
180poly(A)+ mRNA export from nucleus (GO:0016973)2.23123830
181macrophage activation involved in immune response (GO:0002281)2.22489124
182actin filament polymerization (GO:0030041)2.22326329
183amyloid precursor protein metabolic process (GO:0042982)2.21945451
184fusion of sperm to egg plasma membrane (GO:0007342)2.20066613
185positive regulation of keratinocyte differentiation (GO:0045618)2.19793713

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1GATA1_22025678_ChIP-Seq_K562_Human4.23370562
2BP1_19119308_ChIP-ChIP_Hs578T_Human2.96316444
3TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.84259431
4MYC_22102868_ChIP-Seq_BL_Human2.54942266
5IRF8_22096565_ChIP-ChIP_GC-B_Human2.51655605
6IRF8_22096565_ChIP-ChIP_GC-B_Mouse2.24643078
7EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.19901012
8VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human2.17086186
9EGR1_19374776_ChIP-ChIP_THP-1_Human2.15040672
10IRF8_21731497_ChIP-ChIP_J774_Mouse2.12098973
11SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse2.07391997
12FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.06487614
13STAT6_20620947_ChIP-Seq_CD4_POS_T_Human2.04710157
14VDR_21846776_ChIP-Seq_THP-1_Human1.96875060
15ESR2_21235772_ChIP-Seq_MCF-7_Human1.94626706
16* KDM2B_26808549_Chip-Seq_SUP-B15_Human1.89023297
17RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.88259492
18NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.86589658
19TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.85477952
20* MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.84377444
21* SOX2_27498859_Chip-Seq_STOMACH_Mouse1.81504719
22TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.77553786
23GATA1_19941827_ChIP-Seq_MEL_Mouse1.73276986
24FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.71478046
25BCL6_27268052_Chip-Seq_Bcells_Human1.70593579
26BCOR_27268052_Chip-Seq_Bcells_Human1.66613592
27NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.65885851
28E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.63137051
29CIITA_25753668_ChIP-Seq_RAJI_Human1.62991189
30GATA1_19941826_ChIP-Seq_K562_Human1.61895948
31IRF8_27001747_Chip-Seq_BMDM_Mouse1.60676544
32SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.59694150
33SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.59531840
34MAF_26560356_Chip-Seq_TH1_Human1.57884873
35ELF1_17652178_ChIP-ChIP_JURKAT_Human1.57773522
36SPI1_23547873_ChIP-Seq_NB4_Human1.57150066
37* KDM2B_26808549_Chip-Seq_DND41_Human1.54101950
38RUNX_20019798_ChIP-Seq_JUKART_Human1.53758893
39SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.53465849
40P68_20966046_ChIP-Seq_HELA_Human1.50451062
41SMC4_20622854_ChIP-Seq_HELA_Human1.50074310
42MYC_18555785_ChIP-Seq_MESCs_Mouse1.49908981
43* STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.47135193
44ESR1_21235772_ChIP-Seq_MCF-7_Human1.46669894
45PPARA_22158963_ChIP-Seq_LIVER_Mouse1.46645537
46TCF7_22412390_ChIP-Seq_EML_Mouse1.46537770
47* UTX_26944678_Chip-Seq_JUKART_Human1.46343699
48GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.45692848
49MYB_26560356_Chip-Seq_TH2_Human1.45575715
50DROSHA_22980978_ChIP-Seq_HELA_Human1.45307903
51DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.44683873
52MYB_21317192_ChIP-Seq_ERMYB_Mouse1.43451065
53TP63_17297297_ChIP-ChIP_HaCaT_Human1.41076249
54ESR1_20079471_ChIP-ChIP_T-47D_Human1.39464000
55RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.39383901
56PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.37927178
57MYB_26560356_Chip-Seq_TH1_Human1.36866461
58GABP_17652178_ChIP-ChIP_JURKAT_Human1.36284423
59FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.36124344
60ERG_20887958_ChIP-Seq_HPC-7_Mouse1.35963056
61CDX2_20551321_ChIP-Seq_CACO-2_Human1.34588698
62TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.34444917
63RUNX1_22412390_ChIP-Seq_EML_Mouse1.33285555
64GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.32544879
65JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.32539905
66GATA1_22383799_ChIP-Seq_G1ME_Mouse1.32317267
67* MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.31932867
68STAT4_19710469_ChIP-ChIP_TH1__Mouse1.31124940
69ETS1_20019798_ChIP-Seq_JURKAT_Human1.30632449
70GATA6_25053715_ChIP-Seq_YYC3_Human1.30230608
71CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.30200012
72* GATA2_19941826_ChIP-Seq_K562_Human1.29233529
73VDR_24763502_ChIP-Seq_THP-1_Human1.28362762
74STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.28033628
75* NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.27510591
76LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.26900332
77TP63_22573176_ChIP-Seq_HFKS_Human1.26700936
78MYC_19079543_ChIP-ChIP_MESCs_Mouse1.26041129
79SCL_19346495_ChIP-Seq_HPC-7_Human1.25373367
80VDR_23849224_ChIP-Seq_CD4+_Human1.24951809
81CREB1_26743006_Chip-Seq_LNCaP_Human1.24813833
82STAT1_20625510_ChIP-Seq_HELA_Human1.24089112
83P300_27268052_Chip-Seq_Bcells_Human1.23487957
84THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.23338947
85HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.23246596
86GABP_19822575_ChIP-Seq_HepG2_Human1.22796897
87LXR_22292898_ChIP-Seq_THP-1_Human1.22408300
88GATA2_22383799_ChIP-Seq_G1ME_Mouse1.21915035
89* KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.20629813
90CTCF_27219007_Chip-Seq_ERYTHROID_Human1.20122203
91ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.19998410
92SRY_22984422_ChIP-ChIP_TESTIS_Rat1.19920800
93SA1_27219007_Chip-Seq_ERYTHROID_Human1.18914582
94ZNF263_19887448_ChIP-Seq_K562_Human1.18326529
95CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.17558000
96TFEB_21752829_ChIP-Seq_HELA_Human1.17240001
97FOXP3_21729870_ChIP-Seq_TREG_Human1.16520060
98RACK7_27058665_Chip-Seq_MCF-7_Human1.16006942
99SPI1_23127762_ChIP-Seq_K562_Human1.15849457
100SMAD2/3_21741376_ChIP-Seq_ESCs_Human1.14541007
101CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.14195818
102XRN2_22483619_ChIP-Seq_HELA_Human1.14058744
103MYC_18358816_ChIP-ChIP_MESCs_Mouse1.13942894
104TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.13471243
105BRD4_27068464_Chip-Seq_AML-cells_Mouse1.13236239
106MAF_26560356_Chip-Seq_TH2_Human1.13065672
107EST1_17652178_ChIP-ChIP_JURKAT_Human1.12929098
108KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.12920555
109PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.12656581
110RXR_22158963_ChIP-Seq_LIVER_Mouse1.11603691
111SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.11569829
112ATF3_27146783_Chip-Seq_COLON_Human1.10883786
113KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.09830330
114ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.09537406
115E2F1_20622854_ChIP-Seq_HELA_Human1.09014197
116E2F7_22180533_ChIP-Seq_HELA_Human1.08877298
117MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.08325111
118GATA3_27048872_Chip-Seq_THYMUS_Human1.07688279
119NCOR1_26117541_ChIP-Seq_K562_Human1.07495793
120* KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.07074409
121LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.07030863
122E2F1_18555785_ChIP-Seq_MESCs_Mouse1.06758494
123STAT6_21828071_ChIP-Seq_BEAS2B_Human1.06253615
124KLF5_25053715_ChIP-Seq_YYC3_Human1.06069701
125P63_26484246_Chip-Seq_KERATINOCYTES_Human1.05545234
126CREB1_15753290_ChIP-ChIP_HEK293T_Human1.04884401
127STAT3_1855785_ChIP-Seq_MESCs_Mouse1.04382353
128ELK3_25401928_ChIP-Seq_HUVEC_Human1.04351896
129GATA4_25053715_ChIP-Seq_YYC3_Human1.04127717
130IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.03828868
131NANOG_18555785_ChIP-Seq_MESCs_Mouse1.03741647
132PHF8_20622854_ChIP-Seq_HELA_Human1.03684021
133CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.02878071
134GATA2_21666600_ChIP-Seq_HMVEC_Human1.02410738
135YY1_22570637_ChIP-Seq_MALME-3M_Human1.02166894
136RUNX1_27514584_Chip-Seq_MCF-7_Human1.01938824
137PU.1_20513432_ChIP-Seq_Bcells_Mouse1.01459988
138PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse1.01344021
139ELF1_20517297_ChIP-Seq_JURKAT_Human1.00994938
140POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.00822183
141* GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.00153817
142CTCF_21964334_ChIP-Seq_BJAB-B_Human0.99868025
143NOTCH1_21737748_ChIP-Seq_TLL_Human0.98801627
144TET1_21451524_ChIP-Seq_MESCs_Mouse0.98789446
145ELK1_22589737_ChIP-Seq_MCF10A_Human0.98587779
146MYC_19030024_ChIP-ChIP_MESCs_Mouse0.98162422
147CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat0.97821091

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005058_abnormal_lysosome_morphology3.70981751
2MP0003183_abnormal_peptide_metabolism3.38160913
3MP0004264_abnormal_extraembryonic_tissu2.95906966
4MP0002877_abnormal_melanocyte_morpholog2.87406869
5MP0003866_abnormal_defecation2.84460278
6MP0003303_peritoneal_inflammation2.74579691
7MP0010234_abnormal_vibrissa_follicle2.64971827
8MP0009840_abnormal_foam_cell2.50449134
9MP0003763_abnormal_thymus_physiology2.46442451
10MP0002909_abnormal_adrenal_gland2.35746680
11MP0001873_stomach_inflammation2.34743779
12MP0002693_abnormal_pancreas_physiology2.28382876
13MP0001666_abnormal_nutrient_absorption2.19770344
14MP0003693_abnormal_embryo_hatching2.19294895
15MP0005410_abnormal_fertilization2.13262523
16MP0010155_abnormal_intestine_physiology2.11576099
17MP0003300_gastrointestinal_ulcer2.04401992
18MP0000685_abnormal_immune_system2.01578031
19MP0009278_abnormal_bone_marrow1.93722874
20MP0005671_abnormal_response_to1.91384994
21MP0001986_abnormal_taste_sensitivity1.84579909
22MP0001944_abnormal_pancreas_morphology1.82631257
23MP0003283_abnormal_digestive_organ1.82455742
24MP0005379_endocrine/exocrine_gland_phen1.78392025
25MP0001545_abnormal_hematopoietic_system1.76798428
26MP0005397_hematopoietic_system_phenotyp1.76798428
27MP0000013_abnormal_adipose_tissue1.71528721
28MP0000678_abnormal_parathyroid_gland1.71186405
29MP0005365_abnormal_bile_salt1.71065986
30MP0000490_abnormal_crypts_of1.68770429
31MP0002132_abnormal_respiratory_system1.65510114
32MP0010352_gastrointestinal_tract_polyps1.64636916
33MP0002822_catalepsy1.58179909
34MP0001881_abnormal_mammary_gland1.57248603
35MP0009643_abnormal_urine_homeostasis1.57200977
36MP0005451_abnormal_body_composition1.56980077
37MP0005220_abnormal_exocrine_pancreas1.53199829
38MP0009333_abnormal_splenocyte_physiolog1.51630437
39MP0004947_skin_inflammation1.50869897
40MP0000462_abnormal_digestive_system1.50329280
41MP0005310_abnormal_salivary_gland1.49704044
42MP0001835_abnormal_antigen_presentation1.48160306
43MP0004043_abnormal_pH_regulation1.43458729
44MP0008961_abnormal_basal_metabolism1.43128950
45MP0005464_abnormal_platelet_physiology1.42791355
46MP0001800_abnormal_humoral_immune1.42177374
47MP0000465_gastrointestinal_hemorrhage1.40494566
48MP0006054_spinal_hemorrhage1.38244652
49MP0002166_altered_tumor_susceptibility1.37105805
50MP0003436_decreased_susceptibility_to1.35195339
51MP0001765_abnormal_ion_homeostasis1.34186724
52MP0002138_abnormal_hepatobiliary_system1.32616313
53MP0000015_abnormal_ear_pigmentation1.31711218
54MP0003172_abnormal_lysosome_physiology1.28404159
55MP0002723_abnormal_immune_serum1.26620676
56MP0001845_abnormal_inflammatory_respons1.26274631
57MP0001790_abnormal_immune_system1.26012935
58MP0005387_immune_system_phenotype1.26012935
59MP0002405_respiratory_system_inflammati1.25580242
60MP0002398_abnormal_bone_marrow1.24490578
61MP0002420_abnormal_adaptive_immunity1.23553330
62MP0005025_abnormal_response_to1.23300043
63MP0001819_abnormal_immune_cell1.23139159
64MP0009379_abnormal_foot_pigmentation1.21305399
65MP0002139_abnormal_hepatobiliary_system1.20957187
66MP0005174_abnormal_tail_pigmentation1.20912086
67MP0000477_abnormal_intestine_morphology1.20763786
68MP0005083_abnormal_biliary_tract1.20452868
69MP0001756_abnormal_urination1.19733233
70MP0001849_ear_inflammation1.19628743
71MP0002452_abnormal_antigen_presenting1.19443013
72MP0004510_myositis1.19272384
73MP0002796_impaired_skin_barrier1.19075261
74MP0005000_abnormal_immune_tolerance1.18495002
75MP0000716_abnormal_immune_system1.17208570
76MP0001663_abnormal_digestive_system1.15325574
77MP0009764_decreased_sensitivity_to1.14804089
78MP0000538_abnormal_urinary_bladder1.12955232
79MP0003806_abnormal_nucleotide_metabolis1.12617093
80MP0005381_digestive/alimentary_phenotyp1.11741782
81MP0003868_abnormal_feces_composition1.10797265
82MP0005166_decreased_susceptibility_to1.10689133
83MP0004782_abnormal_surfactant_physiolog1.10403232
84MP0003787_abnormal_imprinting1.10021440
85MP0005409_darkened_coat_color1.09942007
86MP0005636_abnormal_mineral_homeostasis1.09901745
87MP0002653_abnormal_ependyma_morphology1.09481314
88MP0002722_abnormal_immune_system1.08102782
89MP0002078_abnormal_glucose_homeostasis1.07131167
90MP0001533_abnormal_skeleton_physiology1.07046663
91MP0009785_altered_susceptibility_to1.06964565
92MP0005085_abnormal_gallbladder_physiolo1.06609781
93MP0002148_abnormal_hypersensitivity_rea1.05750889
94MP0005075_abnormal_melanosome_morpholog1.05622266
95MP0004957_abnormal_blastocyst_morpholog1.05068541
96MP0002837_dystrophic_cardiac_calcinosis1.04524158
97MP0000003_abnormal_adipose_tissue1.04500909
98MP0002429_abnormal_blood_cell1.03535174
99MP0000689_abnormal_spleen_morphology1.02839864
100MP0000609_abnormal_liver_physiology0.99875853
101MP0000703_abnormal_thymus_morphology0.96401447
102MP0005535_abnormal_body_temperature0.95342024
103MP0004019_abnormal_vitamin_homeostasis0.94670010
104MP0003879_abnormal_hair_cell0.94017002
105MP0009765_abnormal_xenobiotic_induced0.93106012
106MP0000613_abnormal_salivary_gland0.92463806
107MP0001664_abnormal_digestion0.92127032
108MP0005645_abnormal_hypothalamus_physiol0.89736862
109MP0003191_abnormal_cellular_cholesterol0.89611482
110MP0001727_abnormal_embryo_implantation0.88398087
111MP0005257_abnormal_intraocular_pressure0.88150872
112MP0002396_abnormal_hematopoietic_system0.87694642
113MP0003718_maternal_effect0.85095961
114MP0008469_abnormal_protein_level0.83244113
115MP0002419_abnormal_innate_immunity0.83196015
116MP0003943_abnormal_hepatobiliary_system0.83022591
117MP0008874_decreased_physiological_sensi0.81611536
118MP0000681_abnormal_thyroid_gland0.81077647
119MP0000230_abnormal_systemic_arterial0.79405167
120MP0003724_increased_susceptibility_to0.78258697
121MP0002136_abnormal_kidney_physiology0.77648776
122MP0000470_abnormal_stomach_morphology0.77570590
123MP0010678_abnormal_skin_adnexa0.77415742
124MP0004808_abnormal_hematopoietic_stem0.77232293
125MP0010386_abnormal_urinary_bladder0.76852687
126MP0005360_urolithiasis0.75798011
127MP0000627_abnormal_mammary_gland0.74554280
128MP0003075_altered_response_to0.74133376
129MP0008004_abnormal_stomach_pH0.73374602
130MP0003953_abnormal_hormone_level0.72708462
131MP0002095_abnormal_skin_pigmentation0.70859181

Predicted human phenotypes

RankGene SetZ-score
1Dysostosis multiplex (HP:0000943)5.38778428
2Hyperinsulinemic hypoglycemia (HP:0000825)4.58290422
3Mucopolysacchariduria (HP:0008155)4.36213872
4Urinary glycosaminoglycan excretion (HP:0003541)4.36213872
5Prolonged bleeding time (HP:0003010)4.16245591
6Absent/shortened dynein arms (HP:0200106)4.12087355
7Dynein arm defect of respiratory motile cilia (HP:0012255)4.12087355
8Respiratory insufficiency due to defective ciliary clearance (HP:0200073)4.08993213
9Abnormality of polysaccharide metabolism (HP:0011012)4.00037440
10Abnormality of glycosaminoglycan metabolism (HP:0004371)4.00037440
11Abnormality of mucopolysaccharide metabolism (HP:0011020)4.00037440
12Hypoglycemic coma (HP:0001325)3.99644253
13Hypoglycemic seizures (HP:0002173)3.95410469
14Abnormal respiratory motile cilium physiology (HP:0012261)3.93425881
15Abnormal ciliary motility (HP:0012262)3.92442639
16Late onset (HP:0003584)3.91077585
17Abnormal respiratory epithelium morphology (HP:0012253)3.89698616
18Abnormal respiratory motile cilium morphology (HP:0005938)3.89698616
19Symptomatic seizures (HP:0011145)3.80303830
20Elevated circulating parathyroid hormone (PTH) level (HP:0003165)3.65948408
21Eczematoid dermatitis (HP:0000976)3.35926446
22Bronchiectasis (HP:0002110)3.29679040
23Rhinitis (HP:0012384)3.26825705
24Petechiae (HP:0000967)3.25175609
25Recurrent sinusitis (HP:0011108)3.19892428
26Interstitial pulmonary disease (HP:0006530)3.05535285
27Thrombocytosis (HP:0001894)3.02129516
28Purpura (HP:0000979)3.01027791
29Decreased circulating renin level (HP:0003351)2.98274087
30Vacuolated lymphocytes (HP:0001922)2.94416095
31Epistaxis (HP:0000421)2.92649768
32Hyperactive renin-angiotensin system (HP:0000841)2.90940985
33Abdominal distention (HP:0003270)2.90288720
34Agammaglobulinemia (HP:0004432)2.89292257
35Hyperglycemia (HP:0003074)2.83841588
36Colitis (HP:0002583)2.80045259
37Gingival bleeding (HP:0000225)2.78255561
38Abnormality of B cell number (HP:0010975)2.78132627
39B lymphocytopenia (HP:0010976)2.78132627
40Generalized aminoaciduria (HP:0002909)2.77953206
41Recurrent abscess formation (HP:0002722)2.77369071
42Tubulointerstitial nephritis (HP:0001970)2.76123368
43Recurrent bacterial skin infections (HP:0005406)2.74461831
44IgM deficiency (HP:0002850)2.72163016
45Increased neuronal autofluorescent lipopigment (HP:0002074)2.71515469
46Ketoacidosis (HP:0001993)2.70122553
47Abnormality of endocrine pancreas physiology (HP:0012093)2.68759972
48Abnormality of the pancreatic islet cells (HP:0006476)2.68759972
49Abnormality of small intestinal villus morphology (HP:0011472)2.68291200
50Villous atrophy (HP:0011473)2.68291200
51Asymmetric septal hypertrophy (HP:0001670)2.66417763
52Hypoplasia of the thymus (HP:0000778)2.62387235
53Malnutrition (HP:0004395)2.61630491
54Insulin-resistant diabetes mellitus (HP:0000831)2.60169632
55Abnormal pancreas size (HP:0012094)2.57447400
56Increased cerebral lipofuscin (HP:0011813)2.56896187
57Chronic sinusitis (HP:0011109)2.55497420
58Panhypogammaglobulinemia (HP:0003139)2.50743613
59Severe short stature (HP:0003510)2.47112160
60Obstructive lung disease (HP:0006536)2.46940039
61Chronic obstructive pulmonary disease (HP:0006510)2.46940039
62Cellulitis (HP:0100658)2.46586485
63Aplastic anemia (HP:0001915)2.46318745
64Pustule (HP:0200039)2.45907474
65Hyperparathyroidism (HP:0000843)2.44417312
66Abnormal protein glycosylation (HP:0012346)2.40397361
67Abnormal glycosylation (HP:0012345)2.40397361
68Abnormal isoelectric focusing of serum transferrin (HP:0003160)2.40397361
69Abnormal protein N-linked glycosylation (HP:0012347)2.40397361
70Meningitis (HP:0001287)2.37675425
71Thoracolumbar scoliosis (HP:0002944)2.37419614
72Vasculitis (HP:0002633)2.37044151
73Pancreatic islet-cell hyperplasia (HP:0004510)2.36691525
74Type I transferrin isoform profile (HP:0003642)2.36296576
75Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)2.36295111
76Abnormal platelet volume (HP:0011876)2.33533472
77Infertility (HP:0000789)2.33366969
78Recurrent bronchitis (HP:0002837)2.33295279
79Insulin resistance (HP:0000855)2.33244245
80Abnormality of T cell physiology (HP:0011840)2.33053417
81Menorrhagia (HP:0000132)2.32460897
82Abnormality of macrophages (HP:0004311)2.30566052
83Elevated erythrocyte sedimentation rate (HP:0003565)2.30361022
84Hyperkalemia (HP:0002153)2.28433235
85Increased IgM level (HP:0003496)2.28111689
86Abnormality of calcium-phosphate metabolism (HP:0100530)2.27497225
87Bronchitis (HP:0012387)2.25865682
88Increased IgE level (HP:0003212)2.25748543
89Autoimmune hemolytic anemia (HP:0001890)2.25661037
90Large for gestational age (HP:0001520)2.25538691
91Nasal polyposis (HP:0100582)2.25516206
92Severe combined immunodeficiency (HP:0004430)2.24166037
93Gingivitis (HP:0000230)2.21967193
94Autoimmune thrombocytopenia (HP:0001973)2.21011043
95Abnormality of the nasal mucosa (HP:0000433)2.20405229
96Increased mean platelet volume (HP:0011877)2.19854465
97Stomach cancer (HP:0012126)2.17415623
98Conjugated hyperbilirubinemia (HP:0002908)2.16333832
99Flat acetabular roof (HP:0003180)2.15664638
100Abnormality of T cells (HP:0002843)2.15507922
101Combined immunodeficiency (HP:0005387)2.14902535
102Chronic bronchitis (HP:0004469)2.14721287
103Abnormality of glutamine family amino acid metabolism (HP:0010902)2.13433987
104Chronic otitis media (HP:0000389)2.13336521
105Recurrent otitis media (HP:0000403)2.12418293
106Gout (HP:0001997)2.11816940
107Severe visual impairment (HP:0001141)2.11521698
108Myositis (HP:0100614)2.10932465
109Abnormality of the vasculature of the conjunctiva (HP:0008054)2.10852932
110Abnormality of the intrinsic pathway (HP:0010989)2.10825270
111Abnormal delayed hypersensitivity skin test (HP:0002963)2.10427602
112Gastrointestinal stroma tumor (HP:0100723)2.09912316
113Mediastinal lymphadenopathy (HP:0100721)2.09551757
114Seborrheic dermatitis (HP:0001051)2.09242067
115Recurrent fungal infections (HP:0002841)2.08730993
116Recurrent viral infections (HP:0004429)2.07681975
117Abnormality of renin-angiotensin system (HP:0000847)2.04993986
118Homocystinuria (HP:0002156)2.04527053
119Abnormality of homocysteine metabolism (HP:0010919)2.04527053
120Parkinsonism with favorable response to dopaminergic medication (HP:0002548)2.03414487
121Oligomenorrhea (HP:0000876)2.02302133
122Amelogenesis imperfecta (HP:0000705)2.01069196
123Chest pain (HP:0100749)2.00438466
124Abnormal platelet function (HP:0011869)2.00035019
125Impaired platelet aggregation (HP:0003540)2.00035019
126Chronic diarrhea (HP:0002028)1.99790539
127Alveolar cell carcinoma (HP:0006519)1.99312426
128Global brain atrophy (HP:0002283)1.99272848
129Stomatitis (HP:0010280)1.99261541
130Abnormal biliary tract morphology (HP:0012440)1.98248911
131Abnormality of vitamin B metabolism (HP:0004340)1.98017502
132Dysautonomia (HP:0002459)1.97537118
133Recurrent skin infections (HP:0001581)1.95610106
134Limb hypertonia (HP:0002509)1.93876753
135Micronodular cirrhosis (HP:0001413)1.93852464
136Neoplasm of the tracheobronchial system (HP:0100552)1.92676539
137Chronic mucocutaneous candidiasis (HP:0002728)1.89924680
138Recurrent cutaneous fungal infections (HP:0011370)1.89924680
139T lymphocytopenia (HP:0005403)1.89447399
140Ankle clonus (HP:0011448)1.88978875
141Progressive muscle weakness (HP:0003323)1.88449675
142Male infertility (HP:0003251)1.86835168
143Cone-rod dystrophy (HP:0000548)1.85318231
144Hypergammaglobulinemia (HP:0010702)1.85253359
145Progressive neurologic deterioration (HP:0002344)1.84980278
146Encephalitis (HP:0002383)1.83808829
147Reduced antithrombin III activity (HP:0001976)1.83764693
148Arterial thrombosis (HP:0004420)1.83596660
149Hemorrhage of the eye (HP:0011885)1.81942119
150Osteomyelitis (HP:0002754)1.81933292
151Acute hepatic failure (HP:0006554)1.80656010
152Abnormality of aromatic amino acid family metabolism (HP:0004338)1.80076517
153Ileus (HP:0002595)1.79988864
154Growth hormone excess (HP:0000845)1.79977172
155Inflammation of the large intestine (HP:0002037)1.79164127
156Gastrointestinal inflammation (HP:0004386)1.78349395
157Failure to thrive in infancy (HP:0001531)1.77978695
158Gastrointestinal infarctions (HP:0005244)1.77665411
159Hyperphosphatemia (HP:0002905)1.77103098
160Abnormality of chloride homeostasis (HP:0011422)1.76515076
161Conjunctival telangiectasia (HP:0000524)1.76098394
162Urticaria (HP:0001025)1.75513274
163Right ventricular cardiomyopathy (HP:0011663)1.74075027
164Menstrual irregularities (HP:0000858)1.74055411
165Ovoid vertebral bodies (HP:0003300)1.73871918
166Hypotension (HP:0002615)1.73755081
167Loss of speech (HP:0002371)1.72693935
168Abnormality of cells of the erythroid lineage (HP:0012130)1.72237320
169Granulocytopenia (HP:0001913)1.71872547
170Prominent metopic ridge (HP:0005487)1.71306167
171Abnormality of T cell number (HP:0011839)1.70756812
172Thyroiditis (HP:0100646)1.70595004
173Joint stiffness (HP:0001387)1.70000912
174Cheilitis (HP:0100825)1.68759421

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAPK154.99785221
2PASK3.48530521
3RIPK43.29015543
4TAOK32.96524855
5ERN12.83903208
6MAP4K12.77325124
7INSRR2.50224797
8TGFBR22.12994725
9EPHA22.04116783
10MET2.00691247
11ZAP701.99091774
12TNK21.99063803
13STK101.97206019
14MAP2K21.95703893
15MAP3K21.86405454
16HIPK21.74705286
17TAOK11.70536368
18FLT31.70494778
19TESK21.69359451
20GRK61.67003128
21TRIB31.64205831
22MST41.59593092
23TBK11.54703552
24ITK1.54411635
25JAK31.52810737
26MST1R1.52060875
27PRPF4B1.51125705
28FGFR41.50980973
29BLK1.49700257
30MAP3K101.48752494
31IRAK41.45984598
32PKN21.43195718
33PIK3CG1.40865969
34PRKG21.40680788
35MAPKAPK31.36525436
36NME21.36036193
37TYK21.34539653
38SIK11.33757645
39SMG11.33172986
40PTK61.33098626
41CSF1R1.28643946
42BTK1.27148112
43IRAK31.22760829
44EEF2K1.22753041
45FRK1.21224205
46PDPK11.20062453
47PDK11.18686950
48TEC1.15735745
49FES1.12353812
50NLK1.12008511
51PTK21.10582650
52SCYL21.09945105
53MARK21.08341714
54TGFBR11.06972133
55MAP3K11.06808126
56CSK1.02092573
57RET0.98380096
58DYRK1B0.98228044
59BMPR1B0.97877534
60RPS6KB20.97551131
61RPS6KA20.96783508
62MAP3K140.89255967
63DYRK30.89185855
64LRRK20.88651465
65HCK0.87577996
66CDK120.87421842
67TXK0.87012547
68BCKDK0.86082225
69IKBKE0.85835950
70LMTK20.85512268
71PRKD20.83257288
72RIPK10.82930073
73LYN0.82150309
74TSSK60.81294165
75MATK0.80526528
76JAK20.78997184
77TESK10.78209147
78SIK30.78193159
79KDR0.73925721
80PIK3CA0.72641353
81MAP3K130.72504321
82LCK0.72062169
83CHUK0.70533603
84BMPR20.70411207
85SYK0.65888131
86NUAK10.64109825
87NEK60.63423206
88RPS6KC10.63405087
89RPS6KL10.63405087
90AKT30.63293728
91MAP2K60.61613689
92MAP2K30.60901281
93ICK0.60147526
94MAP3K60.59576014
95GRK70.58953399
96EPHA30.58856754
97PAK40.57938531
98PRKCQ0.55951377
99DAPK20.55296917
100JAK10.55155846
101PDGFRB0.54939660
102EPHB10.54235462
103MYLK0.53142139
104FGFR30.52903966
105MAP3K30.52517463
106RPS6KA60.50964929
107PRKCI0.50393051
108PIM20.49985249
109ACVR1B0.49885005
110RPS6KA40.49306774
111MAP3K80.49213216
112KSR20.48763164
113IKBKB0.48463724
114PRKD30.48455060
115BMX0.47136085
116GRK50.46564030
117CAMKK10.45744363
118DAPK10.44819146
119BRSK20.44038014
120SIK20.44023635
121MAPK110.43574493
122FER0.42578199
123FYN0.42100959
124PTK2B0.42083831
125MAPK120.41855735
126MAP3K50.40973043
127NME10.38751229
128KIT0.38070417
129CAMKK20.37405410
130CDC42BPA0.37153757
131NEK20.37110823
132NTRK10.36791623
133MAP3K110.36646892
134MAPKAPK20.35735184
135WNK30.35289007
136IRAK10.35281462
137EIF2AK30.34304875
138PIM10.32891053
139MAPK30.31778367

Predicted pathways (KEGG)

RankGene SetZ-score
1Butirosin and neomycin biosynthesis_Homo sapiens_hsa005246.21852492
2Maturity onset diabetes of the young_Homo sapiens_hsa049505.83010965
3Selenocompound metabolism_Homo sapiens_hsa004503.21832156
4Sulfur metabolism_Homo sapiens_hsa009203.11071085
5Protein export_Homo sapiens_hsa030603.00673824
6Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005202.82436256
7Allograft rejection_Homo sapiens_hsa053302.74070814
8Asthma_Homo sapiens_hsa053102.71814174
9Autoimmune thyroid disease_Homo sapiens_hsa053202.53657176
10Other glycan degradation_Homo sapiens_hsa005112.39407288
11Graft-versus-host disease_Homo sapiens_hsa053322.38020228
12Galactose metabolism_Homo sapiens_hsa000522.12542581
13Primary immunodeficiency_Homo sapiens_hsa053402.02341032
14Carbohydrate digestion and absorption_Homo sapiens_hsa049731.97825835
15Fructose and mannose metabolism_Homo sapiens_hsa000511.96068287
16Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.95620069
17Glycosaminoglycan degradation_Homo sapiens_hsa005311.91247377
18Fatty acid biosynthesis_Homo sapiens_hsa000611.74991841
19Antigen processing and presentation_Homo sapiens_hsa046121.70319982
20Cyanoamino acid metabolism_Homo sapiens_hsa004601.66532855
21Fat digestion and absorption_Homo sapiens_hsa049751.63195955
22Folate biosynthesis_Homo sapiens_hsa007901.62009316
23N-Glycan biosynthesis_Homo sapiens_hsa005101.61015094
24Lysosome_Homo sapiens_hsa041421.56524938
25Renin-angiotensin system_Homo sapiens_hsa046141.47916765
26Linoleic acid metabolism_Homo sapiens_hsa005911.42812012
27Staphylococcus aureus infection_Homo sapiens_hsa051501.39603666
28Ribosome_Homo sapiens_hsa030101.38729589
29alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.38064698
30Tuberculosis_Homo sapiens_hsa051521.25960862
31Type II diabetes mellitus_Homo sapiens_hsa049301.24246266
32ABC transporters_Homo sapiens_hsa020101.16792954
33Insulin secretion_Homo sapiens_hsa049111.15198375
34Viral myocarditis_Homo sapiens_hsa054161.14102468
35Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.10018354
36Regulation of autophagy_Homo sapiens_hsa041401.07014297
37Thyroid cancer_Homo sapiens_hsa052161.02243528
38NF-kappa B signaling pathway_Homo sapiens_hsa040641.01782720
39Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.00787265
40RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.99506503
41Phosphatidylinositol signaling system_Homo sapiens_hsa040700.98171364
42Drug metabolism - other enzymes_Homo sapiens_hsa009830.97985855
43Starch and sucrose metabolism_Homo sapiens_hsa005000.94269752
44Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.93626381
45Legionellosis_Homo sapiens_hsa051340.88034433
46Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.85974545
47Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.85789655
48Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.85227715
49Non-homologous end-joining_Homo sapiens_hsa034500.84553936
50Prolactin signaling pathway_Homo sapiens_hsa049170.83400922
51Rheumatoid arthritis_Homo sapiens_hsa053230.83342322
52Acute myeloid leukemia_Homo sapiens_hsa052210.82999752
53Intestinal immune network for IgA production_Homo sapiens_hsa046720.81435468
54One carbon pool by folate_Homo sapiens_hsa006700.81301687
55T cell receptor signaling pathway_Homo sapiens_hsa046600.80966741
56Chemokine signaling pathway_Homo sapiens_hsa040620.80639836
57Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.80363658
58Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.80230509
59Arachidonic acid metabolism_Homo sapiens_hsa005900.79176574
60Leukocyte transendothelial migration_Homo sapiens_hsa046700.78663441
61Glycerophospholipid metabolism_Homo sapiens_hsa005640.77433482
62Adipocytokine signaling pathway_Homo sapiens_hsa049200.75951992
63Pancreatic secretion_Homo sapiens_hsa049720.74998430
64Pentose and glucuronate interconversions_Homo sapiens_hsa000400.74819771
65Chemical carcinogenesis_Homo sapiens_hsa052040.74494611
66Mineral absorption_Homo sapiens_hsa049780.74345717
67Vibrio cholerae infection_Homo sapiens_hsa051100.73061683
68Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.72182330
69Inositol phosphate metabolism_Homo sapiens_hsa005620.71063646
70Phenylalanine metabolism_Homo sapiens_hsa003600.70883197
71Type I diabetes mellitus_Homo sapiens_hsa049400.69879990
72Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.69147712
73Glycerolipid metabolism_Homo sapiens_hsa005610.69147184
74Insulin resistance_Homo sapiens_hsa049310.68541172
75Sulfur relay system_Homo sapiens_hsa041220.66903005
76Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.66871254
77Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.65959308
78Non-small cell lung cancer_Homo sapiens_hsa052230.65274517
79Notch signaling pathway_Homo sapiens_hsa043300.64530062
80Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.61248833
81Choline metabolism in cancer_Homo sapiens_hsa052310.60689705
82B cell receptor signaling pathway_Homo sapiens_hsa046620.60627145
83Histidine metabolism_Homo sapiens_hsa003400.60608220
84Endocytosis_Homo sapiens_hsa041440.60022187
85Hepatitis C_Homo sapiens_hsa051600.57553557
86Steroid hormone biosynthesis_Homo sapiens_hsa001400.56684137
87Measles_Homo sapiens_hsa051620.55457659
88Sphingolipid signaling pathway_Homo sapiens_hsa040710.55178219
89Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.54733649
90Apoptosis_Homo sapiens_hsa042100.54223347
91Tryptophan metabolism_Homo sapiens_hsa003800.53376790
92Phagosome_Homo sapiens_hsa041450.53195353
93Pentose phosphate pathway_Homo sapiens_hsa000300.52623713
94Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.52538762
95Leishmaniasis_Homo sapiens_hsa051400.52436582
96Renin secretion_Homo sapiens_hsa049240.52394392
97Pancreatic cancer_Homo sapiens_hsa052120.51960783
98Thyroid hormone synthesis_Homo sapiens_hsa049180.51331454
99Hematopoietic cell lineage_Homo sapiens_hsa046400.50225842
100African trypanosomiasis_Homo sapiens_hsa051430.49516841
101Base excision repair_Homo sapiens_hsa034100.49031030
102Salivary secretion_Homo sapiens_hsa049700.45655132
103Herpes simplex infection_Homo sapiens_hsa051680.45482998
104Pyrimidine metabolism_Homo sapiens_hsa002400.45314625
105mTOR signaling pathway_Homo sapiens_hsa041500.44683962
106NOD-like receptor signaling pathway_Homo sapiens_hsa046210.43325716
107Peroxisome_Homo sapiens_hsa041460.43097279
108SNARE interactions in vesicular transport_Homo sapiens_hsa041300.42245625
109Vitamin digestion and absorption_Homo sapiens_hsa049770.42204423
110Jak-STAT signaling pathway_Homo sapiens_hsa046300.41966366
111Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.41929128
112Influenza A_Homo sapiens_hsa051640.41648829
113Osteoclast differentiation_Homo sapiens_hsa043800.41053276
114Long-term depression_Homo sapiens_hsa047300.40413149
115Toll-like receptor signaling pathway_Homo sapiens_hsa046200.39831936
116Pertussis_Homo sapiens_hsa051330.39052529
117Caffeine metabolism_Homo sapiens_hsa002320.37806417
118Toxoplasmosis_Homo sapiens_hsa051450.37797038
119Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.37468480
120Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.37026047
121Hepatitis B_Homo sapiens_hsa051610.35496292
122Ether lipid metabolism_Homo sapiens_hsa005650.34715392
123VEGF signaling pathway_Homo sapiens_hsa043700.33601447
124TNF signaling pathway_Homo sapiens_hsa046680.32857087
125Insulin signaling pathway_Homo sapiens_hsa049100.32816591
126Transcriptional misregulation in cancer_Homo sapiens_hsa052020.32266609
127Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.31751449
128Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.31378835
129Viral carcinogenesis_Homo sapiens_hsa052030.30676531
130Sphingolipid metabolism_Homo sapiens_hsa006000.28910154
131Platelet activation_Homo sapiens_hsa046110.27135421
132Central carbon metabolism in cancer_Homo sapiens_hsa052300.25892828
133Epstein-Barr virus infection_Homo sapiens_hsa051690.25144973
134Cysteine and methionine metabolism_Homo sapiens_hsa002700.24810763
135p53 signaling pathway_Homo sapiens_hsa041150.23604127
136Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.21200449
137Shigellosis_Homo sapiens_hsa051310.20426226
138Bile secretion_Homo sapiens_hsa049760.18870324
139Chronic myeloid leukemia_Homo sapiens_hsa052200.18384702
140Longevity regulating pathway - mammal_Homo sapiens_hsa042110.17061568
141Protein digestion and absorption_Homo sapiens_hsa049740.16270880

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