

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | modulation by organism of defense response of other organism involved in symbiotic interaction (GO:0 | 7.71737544 |
| 2 | positive regulation by organism of defense response of other organism involved in symbiotic interact | 7.71737544 |
| 3 | modulation by symbiont of host immune response (GO:0052553) | 7.71737544 |
| 4 | positive regulation by symbiont of host defense response (GO:0052509) | 7.71737544 |
| 5 | modulation by symbiont of host defense response (GO:0052031) | 7.71737544 |
| 6 | modulation by organism of immune response of other organism involved in symbiotic interaction (GO:00 | 7.71737544 |
| 7 | regulation of interferon-beta biosynthetic process (GO:0045357) | 7.63515081 |
| 8 | macrophage activation involved in immune response (GO:0002281) | 5.72998760 |
| 9 | antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G | 5.51927905 |
| 10 | positive regulation of interleukin-8 biosynthetic process (GO:0045416) | 5.40666732 |
| 11 | positive regulation of interferon-alpha production (GO:0032727) | 5.07722178 |
| 12 | response to host immune response (GO:0052572) | 5.05208220 |
| 13 | response to immune response of other organism involved in symbiotic interaction (GO:0052564) | 5.05208220 |
| 14 | negative regulation of interleukin-12 production (GO:0032695) | 5.04804355 |
| 15 | microglial cell activation (GO:0001774) | 4.99597946 |
| 16 | regulation of interferon-alpha production (GO:0032647) | 4.80419795 |
| 17 | neutrophil activation involved in immune response (GO:0002283) | 4.66210913 |
| 18 | regulation of antigen processing and presentation of peptide antigen (GO:0002583) | 4.57388321 |
| 19 | response to defenses of other organism involved in symbiotic interaction (GO:0052173) | 4.57145887 |
| 20 | response to host (GO:0075136) | 4.57145887 |
| 21 | response to host defenses (GO:0052200) | 4.57145887 |
| 22 | oligosaccharide catabolic process (GO:0009313) | 4.49015030 |
| 23 | immunoglobulin mediated immune response (GO:0016064) | 4.45126363 |
| 24 | regulation of interleukin-8 biosynthetic process (GO:0045414) | 4.43663055 |
| 25 | regulation of B cell receptor signaling pathway (GO:0050855) | 4.35765131 |
| 26 | glycolipid catabolic process (GO:0019377) | 4.31972175 |
| 27 | amino sugar catabolic process (GO:0046348) | 4.26922420 |
| 28 | positive regulation of T cell differentiation in thymus (GO:0033089) | 4.13078750 |
| 29 | positive regulation of antigen processing and presentation (GO:0002579) | 4.12017201 |
| 30 | detection of other organism (GO:0098543) | 4.06581669 |
| 31 | ceramide catabolic process (GO:0046514) | 4.02720671 |
| 32 | macrophage activation (GO:0042116) | 4.01261268 |
| 33 | pinocytosis (GO:0006907) | 3.88004098 |
| 34 | positive regulation of mast cell degranulation (GO:0043306) | 3.86419715 |
| 35 | positive regulation of mast cell activation involved in immune response (GO:0033008) | 3.86419715 |
| 36 | myeloid cell activation involved in immune response (GO:0002275) | 3.85587962 |
| 37 | positive regulation of interferon-gamma biosynthetic process (GO:0045078) | 3.82400270 |
| 38 | detection of molecule of bacterial origin (GO:0032490) | 3.81329053 |
| 39 | natural killer cell mediated cytotoxicity (GO:0042267) | 3.79584721 |
| 40 | natural killer cell mediated immunity (GO:0002228) | 3.79584721 |
| 41 | positive regulation of myeloid leukocyte mediated immunity (GO:0002888) | 3.71256042 |
| 42 | detection of bacterium (GO:0016045) | 3.71177582 |
| 43 | N-acetylneuraminate metabolic process (GO:0006054) | 3.67985069 |
| 44 | positive regulation of monocyte chemotaxis (GO:0090026) | 3.67099776 |
| 45 | detection of external biotic stimulus (GO:0098581) | 3.66179919 |
| 46 | cellular extravasation (GO:0045123) | 3.59998292 |
| 47 | positive regulation of interferon-beta production (GO:0032728) | 3.59431466 |
| 48 | positive regulation of prostaglandin secretion (GO:0032308) | 3.57798056 |
| 49 | regulation of cholesterol storage (GO:0010885) | 3.57581037 |
| 50 | regulation of mast cell activation involved in immune response (GO:0033006) | 3.54299913 |
| 51 | I-kappaB phosphorylation (GO:0007252) | 3.53769364 |
| 52 | antigen processing and presentation of endogenous peptide antigen (GO:0002483) | 3.52961886 |
| 53 | antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885) | 3.52961886 |
| 54 | response to peptidoglycan (GO:0032494) | 3.48927351 |
| 55 | T-helper 1 type immune response (GO:0042088) | 3.44597292 |
| 56 | regulation of myeloid leukocyte mediated immunity (GO:0002886) | 3.43958207 |
| 57 | positive regulation of macrophage derived foam cell differentiation (GO:0010744) | 3.43926119 |
| 58 | regulation of mononuclear cell migration (GO:0071675) | 3.42686645 |
| 59 | regulation of prostaglandin secretion (GO:0032306) | 3.32561867 |
| 60 | regulation of antigen processing and presentation (GO:0002577) | 3.32372488 |
| 61 | antigen processing and presentation of endogenous antigen (GO:0019883) | 3.29379288 |
| 62 | respiratory burst (GO:0045730) | 3.29082513 |
| 63 | positive regulation of gamma-delta T cell activation (GO:0046645) | 3.28624742 |
| 64 | negative regulation of interleukin-17 production (GO:0032700) | 3.26425801 |
| 65 | regulation of macrophage chemotaxis (GO:0010758) | 3.24060907 |
| 66 | detection of biotic stimulus (GO:0009595) | 3.21019309 |
| 67 | regulation of interleukin-12 biosynthetic process (GO:0045075) | 3.19084075 |
| 68 | membrane lipid catabolic process (GO:0046466) | 3.17613163 |
| 69 | neutrophil activation (GO:0042119) | 3.13207749 |
| 70 | positive regulation of mast cell activation (GO:0033005) | 3.12458813 |
| 71 | regulation of gamma-delta T cell activation (GO:0046643) | 3.08830097 |
| 72 | positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770) | 3.08500100 |
| 73 | B cell mediated immunity (GO:0019724) | 3.06832971 |
| 74 | neutrophil mediated immunity (GO:0002446) | 3.06192782 |
| 75 | granulocyte activation (GO:0036230) | 3.06167368 |
| 76 | sphingolipid catabolic process (GO:0030149) | 3.05625746 |
| 77 | response to thyroid hormone (GO:0097066) | 3.03794802 |
| 78 | positive regulation of membrane protein ectodomain proteolysis (GO:0051044) | 3.03734291 |
| 79 | positive regulation of syncytium formation by plasma membrane fusion (GO:0060143) | 3.02946902 |
| 80 | regulation of early endosome to late endosome transport (GO:2000641) | 3.02576594 |
| 81 | positive regulation of B cell differentiation (GO:0045579) | 3.00894219 |
| 82 | negative regulation of leukocyte mediated cytotoxicity (GO:0001911) | 2.99335473 |
| 83 | negative regulation of cell killing (GO:0031342) | 2.99335473 |
| 84 | regulation of interferon-gamma biosynthetic process (GO:0045072) | 2.95388958 |
| 85 | response to laminar fluid shear stress (GO:0034616) | 2.95255596 |
| 86 | regulation of monocyte chemotaxis (GO:0090025) | 2.92021978 |
| 87 | positive regulation of lipid storage (GO:0010884) | 2.91712514 |
| 88 | hyaluronan catabolic process (GO:0030214) | 2.90692216 |
| 89 | defense response to protozoan (GO:0042832) | 2.89928331 |
| 90 | cellular response to thyroid hormone stimulus (GO:0097067) | 2.89435500 |
| 91 | Arp2/3 complex-mediated actin nucleation (GO:0034314) | 2.88195040 |
| 92 | myeloid dendritic cell differentiation (GO:0043011) | 2.84848939 |
| 93 | response to muramyl dipeptide (GO:0032495) | 2.84463977 |
| 94 | response to lipoprotein particle (GO:0055094) | 2.83708496 |
| 95 | leukocyte mediated cytotoxicity (GO:0001909) | 2.81585739 |
| 96 | lipoprotein transport (GO:0042953) | 2.81104353 |
| 97 | regulation of superoxide anion generation (GO:0032928) | 2.79691306 |
| 98 | myeloid leukocyte activation (GO:0002274) | 2.79653906 |
| 99 | phagosome maturation (GO:0090382) | 2.79276906 |
| 100 | lipopolysaccharide-mediated signaling pathway (GO:0031663) | 2.79046207 |
| 101 | macrophage differentiation (GO:0030225) | 2.77500821 |
| 102 | positive regulation of cholesterol efflux (GO:0010875) | 2.77284337 |
| 103 | regulation of tumor necrosis factor biosynthetic process (GO:0042534) | 2.76183422 |
| 104 | regulation of macrophage derived foam cell differentiation (GO:0010743) | 2.75907234 |
| 105 | mannose metabolic process (GO:0006013) | 2.75230904 |
| 106 | regulation of mast cell activation (GO:0033003) | 2.75168001 |
| 107 | modulation by symbiont of host cellular process (GO:0044068) | 2.75154894 |
| 108 | glycosphingolipid catabolic process (GO:0046479) | 2.75089657 |
| 109 | negative regulation of T cell differentiation in thymus (GO:0033085) | 2.74722685 |
| 110 | regulation of mast cell degranulation (GO:0043304) | 2.74461541 |
| 111 | NIK/NF-kappaB signaling (GO:0038061) | 2.73374560 |
| 112 | regulation of hypersensitivity (GO:0002883) | 2.73214566 |
| 113 | positive regulation of regulated secretory pathway (GO:1903307) | 2.73044497 |
| 114 | positive regulation of toll-like receptor signaling pathway (GO:0034123) | 2.72818620 |
| 115 | regulation of regulated secretory pathway (GO:1903305) | 2.72409411 |
| 116 | B cell receptor signaling pathway (GO:0050853) | 2.72047572 |
| 117 | bone resorption (GO:0045453) | 2.71319228 |
| 118 | negative regulation of interleukin-1 beta production (GO:0032691) | 2.70980263 |
| 119 | negative regulation of granulocyte differentiation (GO:0030853) | 2.70753435 |
| 120 | superoxide anion generation (GO:0042554) | 2.70665228 |
| 121 | myeloid dendritic cell activation (GO:0001773) | 2.70428350 |
| 122 | barbed-end actin filament capping (GO:0051016) | 2.69250925 |
| 123 | hydrogen peroxide biosynthetic process (GO:0050665) | 2.68241112 |
| 124 | regulation of guanylate cyclase activity (GO:0031282) | 2.67501434 |
| 125 | eosinophil chemotaxis (GO:0048245) | 2.66267499 |
| 126 | monocyte chemotaxis (GO:0002548) | 2.66145686 |
| 127 | interferon-gamma-mediated signaling pathway (GO:0060333) | 2.65742841 |
| 128 | negative regulation of alpha-beta T cell differentiation (GO:0046639) | 2.65602174 |
| 129 | regulation of leukocyte degranulation (GO:0043300) | 2.65471312 |
| 130 | negative regulation of interleukin-8 production (GO:0032717) | 2.65470399 |
| 131 | keratan sulfate catabolic process (GO:0042340) | 2.64665309 |
| 132 | germinal center formation (GO:0002467) | 2.64369740 |
| 133 | chondrocyte proliferation (GO:0035988) | 2.63921789 |
| 134 | negative regulation of antigen receptor-mediated signaling pathway (GO:0050858) | 2.63360354 |
| 135 | hepatocyte apoptotic process (GO:0097284) | 2.63245142 |
| 136 | negative regulation of nitric oxide biosynthetic process (GO:0045019) | 2.63126156 |
| 137 | positive regulation of leukocyte degranulation (GO:0043302) | 2.62626897 |
| 138 | lysosome organization (GO:0007040) | 2.61487050 |
| 139 | lytic vacuole organization (GO:0080171) | 2.61487050 |
| 140 | apoptotic cell clearance (GO:0043277) | 2.59599197 |
| 141 | actin filament polymerization (GO:0030041) | 2.59499711 |
| 142 | regulation of interferon-beta production (GO:0032648) | 2.59484718 |
| 143 | negative regulation of lipid storage (GO:0010888) | 2.59297017 |
| 144 | positive regulation of cellular amide metabolic process (GO:0034250) | 2.58327151 |
| 145 | regulation of T cell tolerance induction (GO:0002664) | 2.58180670 |
| 146 | cytidine deamination (GO:0009972) | 2.58078734 |
| 147 | cytidine metabolic process (GO:0046087) | 2.58078734 |
| 148 | cytidine catabolic process (GO:0006216) | 2.58078734 |
| 149 | positive regulation of bone resorption (GO:0045780) | 2.57720251 |
| 150 | positive regulation of bone remodeling (GO:0046852) | 2.57720251 |
| 151 | glycosylceramide metabolic process (GO:0006677) | 2.57369873 |
| 152 | regulation of dendritic cell antigen processing and presentation (GO:0002604) | 2.53590880 |
| 153 | cellular response to interferon-gamma (GO:0071346) | 2.52013588 |
| 154 | neutrophil chemotaxis (GO:0030593) | 2.51716011 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | IRF8_21731497_ChIP-ChIP_J774_Mouse | 6.37573465 |
| 2 | IRF8_22096565_ChIP-ChIP_GC-B_Human | 5.05599949 |
| 3 | * IRF8_27001747_Chip-Seq_BMDM_Mouse | 4.32576527 |
| 4 | BP1_19119308_ChIP-ChIP_Hs578T_Human | 4.11824154 |
| 5 | SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse | 4.08422090 |
| 6 | NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse | 3.71360196 |
| 7 | Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse | 3.69856398 |
| 8 | MECOM_23826213_ChIP-Seq_KASUMI_Mouse | 2.94370580 |
| 9 | IRF1_21803131_ChIP-Seq_MONOCYTES_Human | 2.79018980 |
| 10 | EGR1_19374776_ChIP-ChIP_THP-1_Human | 2.66600933 |
| 11 | NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse | 2.60984431 |
| 12 | MYB_21317192_ChIP-Seq_ERMYB_Mouse | 2.60572085 |
| 13 | NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human | 2.54893687 |
| 14 | BRD4_27068464_Chip-Seq_AML-cells_Mouse | 2.45625794 |
| 15 | * IRF8_22096565_ChIP-ChIP_GC-B_Mouse | 2.45166421 |
| 16 | TP63_17297297_ChIP-ChIP_HaCaT_Human | 2.42280365 |
| 17 | FOXP3_17237761_ChIP-ChIP_TREG_Mouse | 2.31557171 |
| 18 | STAT3_20064451_ChIP-Seq_CD4+T_Mouse | 2.29415358 |
| 19 | CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human | 2.28657663 |
| 20 | PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse | 2.16708095 |
| 21 | * VDR_21846776_ChIP-Seq_THP-1_Human | 2.07178681 |
| 22 | SPI1_23127762_ChIP-Seq_K562_Human | 2.07125346 |
| 23 | RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human | 2.06521573 |
| 24 | * SPI1_22096565_ChIP-ChIP_GC-B_Mouse | 2.06239964 |
| 25 | STAT6_20620947_ChIP-Seq_CD4_POS_T_Human | 2.02346619 |
| 26 | * VDR_24763502_ChIP-Seq_THP-1_Human | 1.98176791 |
| 27 | SPI1_23547873_ChIP-Seq_NB4_Human | 1.95512619 |
| 28 | STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse | 1.80415237 |
| 29 | STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse | 1.79888921 |
| 30 | LYL1_20887958_ChIP-Seq_HPC-7_Mouse | 1.79622022 |
| 31 | RUNX1_22412390_ChIP-Seq_EML_Mouse | 1.77243230 |
| 32 | STAT4_19710469_ChIP-ChIP_TH1__Mouse | 1.73236478 |
| 33 | THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse | 1.72276013 |
| 34 | CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse | 1.71877553 |
| 35 | PU_27001747_Chip-Seq_BMDM_Mouse | 1.69340918 |
| 36 | CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse | 1.60636647 |
| 37 | NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human | 1.59969358 |
| 38 | E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human | 1.59642650 |
| 39 | * ASXL1_24218140_ChIP-Seq_BMDM_Mouse | 1.56842535 |
| 40 | RUNX1_20887958_ChIP-Seq_HPC-7_Mouse | 1.54865358 |
| 41 | GATA1_22025678_ChIP-Seq_K562_Human | 1.54238904 |
| 42 | * VDR_24787735_ChIP-Seq_THP-1_Human | 1.53180866 |
| 43 | PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse | 1.45806701 |
| 44 | GATA2_21666600_ChIP-Seq_HMVEC_Human | 1.44404477 |
| 45 | MAF_26560356_Chip-Seq_TH1_Human | 1.43364028 |
| 46 | * VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human | 1.40835682 |
| 47 | FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse | 1.39452993 |
| 48 | PPARG_19300518_ChIP-PET_3T3-L1_Mouse | 1.38415526 |
| 49 | RUNX_20019798_ChIP-Seq_JUKART_Human | 1.36819753 |
| 50 | GATA2_20887958_ChIP-Seq_HPC-7_Mouse | 1.36420664 |
| 51 | SCL_19346495_ChIP-Seq_HPC-7_Human | 1.34916700 |
| 52 | IKZF1_21737484_ChIP-ChIP_HCT116_Human | 1.34557943 |
| 53 | ELK3_25401928_ChIP-Seq_HUVEC_Human | 1.33406859 |
| 54 | FOXO3_23340844_ChIP-Seq_DLD1_Human | 1.33068007 |
| 55 | CDX2_19796622_ChIP-Seq_MESCs_Mouse | 1.26867018 |
| 56 | CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse | 1.26691467 |
| 57 | CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse | 1.26293229 |
| 58 | CDX2_20551321_ChIP-Seq_CACO-2_Human | 1.26281624 |
| 59 | TCF7_22412390_ChIP-Seq_EML_Mouse | 1.25858856 |
| 60 | * SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse | 1.22303763 |
| 61 | MYB_26560356_Chip-Seq_TH2_Human | 1.21706538 |
| 62 | RARG_19884340_ChIP-ChIP_MEFs_Mouse | 1.19829244 |
| 63 | GATA2_22383799_ChIP-Seq_G1ME_Mouse | 1.19692229 |
| 64 | SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse | 1.18719862 |
| 65 | TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human | 1.18494607 |
| 66 | LXR_22292898_ChIP-Seq_THP-1_Human | 1.18388616 |
| 67 | KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human | 1.16448886 |
| 68 | PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse | 1.15643673 |
| 69 | GATA1_22383799_ChIP-Seq_G1ME_Mouse | 1.14688858 |
| 70 | BCL6_27268052_Chip-Seq_Bcells_Human | 1.14431489 |
| 71 | MEIS1_20887958_ChIP-Seq_HPC-7_Mouse | 1.14165668 |
| 72 | BCOR_27268052_Chip-Seq_Bcells_Human | 1.13534424 |
| 73 | TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse | 1.11897479 |
| 74 | CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human | 1.10107901 |
| 75 | SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse | 1.09764086 |
| 76 | LMO2_20887958_ChIP-Seq_HPC-7_Mouse | 1.09623637 |
| 77 | SOX2_27498859_Chip-Seq_STOMACH_Mouse | 1.08899302 |
| 78 | STAT1_20625510_ChIP-Seq_HELA_Human | 1.08742858 |
| 79 | SOX2_20726797_ChIP-Seq_SW620_Human | 1.08473032 |
| 80 | CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse | 1.07298588 |
| 81 | PPARA_22158963_ChIP-Seq_LIVER_Mouse | 1.06713810 |
| 82 | MYB_26560356_Chip-Seq_TH1_Human | 1.06153248 |
| 83 | GATA3_26560356_Chip-Seq_TH2_Human | 1.05795683 |
| 84 | KDM2B_26808549_Chip-Seq_SUP-B15_Human | 1.05442459 |
| 85 | GATA6_25053715_ChIP-Seq_YYC3_Human | 1.05384172 |
| 86 | P63_26484246_Chip-Seq_KERATINOCYTES_Human | 1.03582074 |
| 87 | UTX_26944678_Chip-Seq_JUKART_Human | 1.03240064 |
| 88 | KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human | 1.02751934 |
| 89 | TFEB_21752829_ChIP-Seq_HELA_Human | 1.00507464 |
| 90 | SMAD_19615063_ChIP-ChIP_OVARY_Human | 1.00146897 |
| 91 | GATA3_27048872_Chip-Seq_THYMUS_Human | 0.99743277 |
| 92 | TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse | 0.99486097 |
| 93 | KDM2B_26808549_Chip-Seq_SIL-ALL_Human | 0.99440498 |
| 94 | * FLI1_20887958_ChIP-Seq_HPC-7_Mouse | 0.99423877 |
| 95 | FOXO1_23066095_ChIP-Seq_LIVER_Mouse | 0.98901230 |
| 96 | SMAD4_19686287_ChIP-ChIP_HaCaT_Human | 0.98683952 |
| 97 | PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse | 0.97839338 |
| 98 | RACK7_27058665_Chip-Seq_MCF-7_Human | 0.97576070 |
| 99 | ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse | 0.96948938 |
| 100 | VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human | 0.96388294 |
| 101 | KDM2B_26808549_Chip-Seq_DND41_Human | 0.95643090 |
| 102 | JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human | 0.94702679 |
| 103 | SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human | 0.94472390 |
| 104 | JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human | 0.92521885 |
| 105 | MAF_26560356_Chip-Seq_TH2_Human | 0.92476696 |
| 106 | GATA1_19941826_ChIP-Seq_K562_Human | 0.92391345 |
| 107 | RXR_22158963_ChIP-Seq_LIVER_Mouse | 0.92354964 |
| 108 | PPARD_23208498_ChIP-Seq_MDA-MB-231_Human | 0.92102424 |
| 109 | CEBPB_23403033_ChIP-Seq_LIVER_Mouse | 0.91824466 |
| 110 | ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human | 0.91742175 |
| 111 | GATA1_19941827_ChIP-Seq_MEL_Mouse | 0.91466544 |
| 112 | GATA4_25053715_ChIP-Seq_YYC3_Human | 0.91065021 |
| 113 | ESR1_17901129_ChIP-ChIP_LIVER_Mouse | 0.90462730 |
| 114 | GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human | 0.88835000 |
| 115 | GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human | 0.88641317 |
| 116 | GATA2_19941826_ChIP-Seq_K562_Human | 0.87850018 |
| 117 | PPAR_26484153_Chip-Seq_NCI-H1993_Human | 0.87295338 |
| 118 | MYC_22102868_ChIP-Seq_BL_Human | 0.86820597 |
| 119 | EGR1_19032775_ChIP-ChIP_M12_Human | 0.86671622 |
| 120 | LXR_22158963_ChIP-Seq_LIVER_Mouse | 0.86253117 |
| 121 | STAT6_21828071_ChIP-Seq_BEAS2B_Human | 0.83225689 |
| 122 | ELF1_20517297_ChIP-Seq_JURKAT_Human | 0.78295004 |
| 123 | ESR2_21235772_ChIP-Seq_MCF-7_Human | 0.78098975 |
| 124 | PU.1_20513432_ChIP-Seq_Bcells_Mouse | 0.77112784 |
| 125 | ESR1_21235772_ChIP-Seq_MCF-7_Human | 0.76586778 |
| 126 | SPI1_20517297_ChIP-Seq_HL60_Human | 0.75672357 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | MP0005058_abnormal_lysosome_morphology | 4.99302843 |
| 2 | MP0003283_abnormal_digestive_organ | 3.78095537 |
| 3 | MP0001835_abnormal_antigen_presentation | 3.53048127 |
| 4 | MP0003303_peritoneal_inflammation | 3.44882365 |
| 5 | MP0006082_CNS_inflammation | 3.33359788 |
| 6 | MP0003191_abnormal_cellular_cholesterol | 3.22731004 |
| 7 | MP0003172_abnormal_lysosome_physiology | 3.17487723 |
| 8 | MP0003436_decreased_susceptibility_to | 3.01492691 |
| 9 | MP0002822_catalepsy | 3.00803313 |
| 10 | MP0005167_abnormal_blood-brain_barrier | 2.90986947 |
| 11 | MP0009840_abnormal_foam_cell | 2.89478594 |
| 12 | MP0002419_abnormal_innate_immunity | 2.63026193 |
| 13 | MP0003300_gastrointestinal_ulcer | 2.61993515 |
| 14 | MP0003878_abnormal_ear_physiology | 2.41236102 |
| 15 | MP0005377_hearing/vestibular/ear_phenot | 2.41236102 |
| 16 | MP0002148_abnormal_hypersensitivity_rea | 2.33548186 |
| 17 | MP0000569_abnormal_digit_pigmentation | 2.30917594 |
| 18 | MP0005000_abnormal_immune_tolerance | 2.29229514 |
| 19 | MP0002139_abnormal_hepatobiliary_system | 2.17759856 |
| 20 | MP0002452_abnormal_antigen_presenting | 2.17646192 |
| 21 | MP0009785_altered_susceptibility_to | 2.15735107 |
| 22 | MP0003690_abnormal_glial_cell | 2.10105352 |
| 23 | MP0001790_abnormal_immune_system | 2.08922190 |
| 24 | MP0005387_immune_system_phenotype | 2.08922190 |
| 25 | MP0005025_abnormal_response_to | 2.08504951 |
| 26 | MP0001800_abnormal_humoral_immune | 1.98191537 |
| 27 | MP0009278_abnormal_bone_marrow | 1.86308996 |
| 28 | MP0002723_abnormal_immune_serum | 1.85327592 |
| 29 | MP0005451_abnormal_body_composition | 1.82958856 |
| 30 | MP0003705_abnormal_hypodermis_morpholog | 1.79524545 |
| 31 | MP0004947_skin_inflammation | 1.74504640 |
| 32 | MP0001533_abnormal_skeleton_physiology | 1.73690970 |
| 33 | MP0001819_abnormal_immune_cell | 1.72442551 |
| 34 | MP0005310_abnormal_salivary_gland | 1.70642909 |
| 35 | MP0002420_abnormal_adaptive_immunity | 1.69881851 |
| 36 | MP0000604_amyloidosis | 1.69867891 |
| 37 | MP0000685_abnormal_immune_system | 1.66826128 |
| 38 | MP0005464_abnormal_platelet_physiology | 1.63662385 |
| 39 | MP0003329_amyloid_beta_deposits | 1.58034434 |
| 40 | MP0005257_abnormal_intraocular_pressure | 1.57279287 |
| 41 | MP0010155_abnormal_intestine_physiology | 1.57132874 |
| 42 | MP0004510_myositis | 1.56833658 |
| 43 | MP0003566_abnormal_cell_adhesion | 1.54437059 |
| 44 | MP0000343_altered_response_to | 1.51827514 |
| 45 | MP0002166_altered_tumor_susceptibility | 1.51561090 |
| 46 | MP0005671_abnormal_response_to | 1.49025390 |
| 47 | MP0001845_abnormal_inflammatory_respons | 1.47260842 |
| 48 | MP0003448_altered_tumor_morphology | 1.43523274 |
| 49 | MP0003075_altered_response_to | 1.36777462 |
| 50 | MP0010307_abnormal_tumor_latency | 1.36411409 |
| 51 | MP0002405_respiratory_system_inflammati | 1.33139884 |
| 52 | MP0003806_abnormal_nucleotide_metabolis | 1.32644690 |
| 53 | MP0008469_abnormal_protein_level | 1.28013822 |
| 54 | MP0003453_abnormal_keratinocyte_physiol | 1.26650073 |
| 55 | MP0002254_reproductive_system_inflammat | 1.23667632 |
| 56 | MP0008875_abnormal_xenobiotic_pharmacok | 1.23097243 |
| 57 | MP0005365_abnormal_bile_salt | 1.22561585 |
| 58 | MP0000490_abnormal_crypts_of | 1.22496053 |
| 59 | MP0008438_abnormal_cutaneous_collagen | 1.22253425 |
| 60 | MP0003724_increased_susceptibility_to | 1.20895895 |
| 61 | MP0000716_abnormal_immune_system | 1.15316117 |
| 62 | MP0002998_abnormal_bone_remodeling | 1.14251031 |
| 63 | MP0002006_tumorigenesis | 1.11596007 |
| 64 | MP0005166_decreased_susceptibility_to | 1.11554440 |
| 65 | MP0008260_abnormal_autophagy | 1.11332422 |
| 66 | MP0000689_abnormal_spleen_morphology | 1.10145937 |
| 67 | MP0003866_abnormal_defecation | 1.07449653 |
| 68 | MP0001873_stomach_inflammation | 1.04650083 |
| 69 | MP0002398_abnormal_bone_marrow | 1.03939570 |
| 70 | MP0005076_abnormal_cell_differentiation | 1.03190705 |
| 71 | MP0000465_gastrointestinal_hemorrhage | 1.03177934 |
| 72 | MP0005397_hematopoietic_system_phenotyp | 1.02844148 |
| 73 | MP0001545_abnormal_hematopoietic_system | 1.02844148 |
| 74 | MP0004883_abnormal_blood_vessel | 1.02139465 |
| 75 | MP0003195_calcinosis | 1.00944985 |
| 76 | MP0000920_abnormal_myelination | 1.00920170 |
| 77 | MP0008004_abnormal_stomach_pH | 0.98384656 |
| 78 | MP0003183_abnormal_peptide_metabolism | 0.97171128 |
| 79 | MP0002429_abnormal_blood_cell | 0.95174100 |
| 80 | MP0010352_gastrointestinal_tract_polyps | 0.93966775 |
| 81 | MP0000858_altered_metastatic_potential | 0.93012627 |
| 82 | MP0005174_abnormal_tail_pigmentation | 0.91059604 |
| 83 | MP0009333_abnormal_splenocyte_physiolog | 0.90182462 |
| 84 | MP0005390_skeleton_phenotype | 0.90153560 |
| 85 | MP0000371_diluted_coat_color | 0.90018216 |
| 86 | MP0001663_abnormal_digestive_system | 0.89410365 |
| 87 | MP0002138_abnormal_hepatobiliary_system | 0.88608074 |
| 88 | MP0010234_abnormal_vibrissa_follicle | 0.87742012 |
| 89 | MP0001851_eye_inflammation | 0.86662655 |
| 90 | MP0001853_heart_inflammation | 0.85738147 |
| 91 | MP0002722_abnormal_immune_system | 0.85457509 |
| 92 | MP0005381_digestive/alimentary_phenotyp | 0.85444565 |
| 93 | MP0000015_abnormal_ear_pigmentation | 0.83603932 |
| 94 | MP0002090_abnormal_vision | 0.83281568 |
| 95 | MP0003828_pulmonary_edema | 0.83243340 |
| 96 | MP0004130_abnormal_muscle_cell | 0.80310888 |
| 97 | MP0005165_increased_susceptibility_to | 0.79737099 |
| 98 | MP0000249_abnormal_blood_vessel | 0.79497255 |
| 99 | MP0000477_abnormal_intestine_morphology | 0.78803700 |
| 100 | MP0004185_abnormal_adipocyte_glucose | 0.77916606 |
| 101 | MP0003795_abnormal_bone_structure | 0.77560854 |
| 102 | MP0002277_abnormal_respiratory_mucosa | 0.76197018 |
| 103 | MP0001849_ear_inflammation | 0.75313553 |
| 104 | MP0006054_spinal_hemorrhage | 0.73683799 |
| 105 | MP0000767_abnormal_smooth_muscle | 0.73403800 |
| 106 | MP0009764_decreased_sensitivity_to | 0.71974557 |
| 107 | MP0002136_abnormal_kidney_physiology | 0.71757879 |
| 108 | MP0000609_abnormal_liver_physiology | 0.71590382 |
| 109 | MP0002933_joint_inflammation | 0.71033560 |
| 110 | MP0008873_increased_physiological_sensi | 0.69866626 |
| 111 | MP0002877_abnormal_melanocyte_morpholog | 0.69627142 |
| 112 | MP0000462_abnormal_digestive_system | 0.69406941 |
| 113 | MP0009643_abnormal_urine_homeostasis | 0.68216197 |
| 114 | MP0004019_abnormal_vitamin_homeostasis | 0.68083708 |
| 115 | MP0003763_abnormal_thymus_physiology | 0.64566321 |
| 116 | MP0003632_abnormal_nervous_system | 0.64070243 |
| 117 | MP0005647_abnormal_sex_gland | 0.63817402 |
| 118 | MP0009763_increased_sensitivity_to | 0.63566105 |
| 119 | MP0003656_abnormal_erythrocyte_physiolo | 0.63385104 |
| 120 | MP0001958_emphysema | 0.63156519 |
| 121 | MP0005164_abnormal_response_to | 0.62504144 |
| 122 | MP0005319_abnormal_enzyme/_coenzyme | 0.62133843 |
| 123 | MP0003091_abnormal_cell_migration | 0.61658107 |
| 124 | MP0001216_abnormal_epidermal_layer | 0.61531383 |
| 125 | MP0003045_fibrosis | 0.61164320 |
| 126 | MP0002332_abnormal_exercise_endurance | 0.58692382 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | Increased cerebral lipofuscin (HP:0011813) | 6.44155813 |
| 2 | Vacuolated lymphocytes (HP:0001922) | 5.93651910 |
| 3 | Recurrent abscess formation (HP:0002722) | 5.29564027 |
| 4 | Increased neuronal autofluorescent lipopigment (HP:0002074) | 5.26626589 |
| 5 | Systemic lupus erythematosus (HP:0002725) | 4.90819087 |
| 6 | Dysostosis multiplex (HP:0000943) | 4.89687493 |
| 7 | Abnormality of liposaccharide metabolism (HP:0010968) | 4.83653037 |
| 8 | Abnormality of glycosphingolipid metabolism (HP:0004343) | 4.83653037 |
| 9 | Abnormality of glycolipid metabolism (HP:0010969) | 4.83653037 |
| 10 | Recurrent bacterial skin infections (HP:0005406) | 4.62457724 |
| 11 | Mucopolysacchariduria (HP:0008155) | 4.31594098 |
| 12 | Urinary glycosaminoglycan excretion (HP:0003541) | 4.31594098 |
| 13 | Eczematoid dermatitis (HP:0000976) | 4.31111900 |
| 14 | Abnormality of macrophages (HP:0004311) | 4.13046665 |
| 15 | Axonal loss (HP:0003447) | 4.12020956 |
| 16 | Abnormality of mucopolysaccharide metabolism (HP:0011020) | 4.09803146 |
| 17 | Abnormality of polysaccharide metabolism (HP:0011012) | 4.09803146 |
| 18 | Abnormality of glycosaminoglycan metabolism (HP:0004371) | 4.09803146 |
| 19 | Disinhibition (HP:0000734) | 4.06210917 |
| 20 | Glomerulonephritis (HP:0000099) | 3.76447924 |
| 21 | Primitive reflexes (palmomental, snout, glabellar) (HP:0002476) | 3.61112748 |
| 22 | Recurrent gram-negative bacterial infections (HP:0005420) | 3.60200506 |
| 23 | Cupped ribs (HP:0000887) | 3.39328154 |
| 24 | Loss of speech (HP:0002371) | 3.21124116 |
| 25 | Neurofibrillary tangles (HP:0002185) | 3.21014588 |
| 26 | Autoimmune thrombocytopenia (HP:0001973) | 3.18559653 |
| 27 | Abnormality of the 1st metacarpal (HP:0010009) | 3.12698672 |
| 28 | Stomatitis (HP:0010280) | 2.99757253 |
| 29 | Pustule (HP:0200039) | 2.96448777 |
| 30 | Agnosia (HP:0010524) | 2.94621016 |
| 31 | Retrobulbar optic neuritis (HP:0100654) | 2.92669183 |
| 32 | Optic neuritis (HP:0100653) | 2.92669183 |
| 33 | Flat acetabular roof (HP:0003180) | 2.90300655 |
| 34 | Myocardial infarction (HP:0001658) | 2.87617527 |
| 35 | Ovoid vertebral bodies (HP:0003300) | 2.85947437 |
| 36 | Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204) | 2.77757561 |
| 37 | Spontaneous hematomas (HP:0007420) | 2.76753476 |
| 38 | Myositis (HP:0100614) | 2.69711198 |
| 39 | Abnormality of the distal phalanx of the thumb (HP:0009617) | 2.69378756 |
| 40 | Hepatosplenomegaly (HP:0001433) | 2.68571314 |
| 41 | Gingivitis (HP:0000230) | 2.66951595 |
| 42 | Recurrent skin infections (HP:0001581) | 2.65960888 |
| 43 | Upper motor neuron abnormality (HP:0002127) | 2.65085957 |
| 44 | Complement deficiency (HP:0004431) | 2.64988756 |
| 45 | Abnormality of complement system (HP:0005339) | 2.64421967 |
| 46 | Global brain atrophy (HP:0002283) | 2.61826803 |
| 47 | Amyloidosis (HP:0011034) | 2.57574893 |
| 48 | Purpura (HP:0000979) | 2.50337589 |
| 49 | Retinal atrophy (HP:0001105) | 2.49737573 |
| 50 | J-shaped sella turcica (HP:0002680) | 2.45285254 |
| 51 | Flared iliac wings (HP:0002869) | 2.41471678 |
| 52 | Elevated erythrocyte sedimentation rate (HP:0003565) | 2.41282852 |
| 53 | Abnormality of the vasculature of the conjunctiva (HP:0008054) | 2.34124241 |
| 54 | Pulmonary infiltrates (HP:0002113) | 2.33851281 |
| 55 | Recurrent cutaneous fungal infections (HP:0011370) | 2.32614692 |
| 56 | Chronic mucocutaneous candidiasis (HP:0002728) | 2.32614692 |
| 57 | Orchitis (HP:0100796) | 2.32384246 |
| 58 | Chronic obstructive pulmonary disease (HP:0006510) | 2.31785495 |
| 59 | Obstructive lung disease (HP:0006536) | 2.31785495 |
| 60 | Symphalangism affecting the phalanges of the hand (HP:0009773) | 2.31024438 |
| 61 | Nephritis (HP:0000123) | 2.29931416 |
| 62 | Asymmetric septal hypertrophy (HP:0001670) | 2.29836962 |
| 63 | Mediastinal lymphadenopathy (HP:0100721) | 2.28563125 |
| 64 | Recurrent fungal infections (HP:0002841) | 2.25765873 |
| 65 | Prostate neoplasm (HP:0100787) | 2.25562825 |
| 66 | Neuronal loss in central nervous system (HP:0002529) | 2.25328283 |
| 67 | Increased serum ferritin (HP:0003281) | 2.24995544 |
| 68 | Abnormality of the periventricular white matter (HP:0002518) | 2.24192169 |
| 69 | Metaphyseal irregularity (HP:0003025) | 2.22587834 |
| 70 | Recurrent viral infections (HP:0004429) | 2.22507478 |
| 71 | Abnormality of the proximal phalanges of the hand (HP:0009834) | 2.22385965 |
| 72 | Hematochezia (HP:0002573) | 2.20960294 |
| 73 | Cerebral inclusion bodies (HP:0100314) | 2.20677501 |
| 74 | Hemoptysis (HP:0002105) | 2.20280756 |
| 75 | Increased CSF protein (HP:0002922) | 2.18783402 |
| 76 | Abnormality of the 2nd finger (HP:0004100) | 2.18274199 |
| 77 | Short phalanx of the thumb (HP:0009660) | 2.17696579 |
| 78 | Aplasia/Hypoplasia involving the femoral head and neck (HP:0009108) | 2.16672285 |
| 79 | Cellulitis (HP:0100658) | 2.16602415 |
| 80 | Petechiae (HP:0000967) | 2.16531676 |
| 81 | Basal ganglia calcification (HP:0002135) | 2.16356144 |
| 82 | Abnormality of carpal bone ossification (HP:0006257) | 2.16327101 |
| 83 | Thoracic kyphosis (HP:0002942) | 2.16183823 |
| 84 | Peripheral demyelination (HP:0011096) | 2.15592986 |
| 85 | Diminished motivation (HP:0000745) | 2.14356472 |
| 86 | Apathy (HP:0000741) | 2.14306610 |
| 87 | Keratoconjunctivitis sicca (HP:0001097) | 2.14086040 |
| 88 | Bone pain (HP:0002653) | 2.12281745 |
| 89 | Colitis (HP:0002583) | 2.11692406 |
| 90 | Relative macrocephaly (HP:0004482) | 2.11515443 |
| 91 | Meningitis (HP:0001287) | 2.10571178 |
| 92 | Periodontitis (HP:0000704) | 2.08353302 |
| 93 | Mutism (HP:0002300) | 2.07515349 |
| 94 | Pathologic fracture (HP:0002756) | 2.07430907 |
| 95 | T lymphocytopenia (HP:0005403) | 2.06180391 |
| 96 | Nuclear cataract (HP:0100018) | 2.04459826 |
| 97 | Abnormality of the lumbar spine (HP:0100712) | 2.02969481 |
| 98 | Keratoconjunctivitis (HP:0001096) | 2.02443250 |
| 99 | Dementia (HP:0000726) | 2.00699151 |
| 100 | Inflammation of the large intestine (HP:0002037) | 2.00396153 |
| 101 | Chronic otitis media (HP:0000389) | 2.00208688 |
| 102 | Conjunctival telangiectasia (HP:0000524) | 1.99638458 |
| 103 | Polyneuropathy (HP:0001271) | 1.98748772 |
| 104 | Urticaria (HP:0001025) | 1.98488814 |
| 105 | Interstitial pulmonary disease (HP:0006530) | 1.98138739 |
| 106 | Abdominal distention (HP:0003270) | 1.97160865 |
| 107 | Xanthomatosis (HP:0000991) | 1.97054203 |
| 108 | Gastrointestinal inflammation (HP:0004386) | 1.95782273 |
| 109 | Increased IgE level (HP:0003212) | 1.94748763 |
| 110 | Progressive visual loss (HP:0000529) | 1.94440517 |
| 111 | Thick nail (HP:0001805) | 1.93705092 |
| 112 | Inappropriate behavior (HP:0000719) | 1.91219713 |
| 113 | Abnormality of iron homeostasis (HP:0011031) | 1.90353532 |
| 114 | Esophageal varix (HP:0002040) | 1.90341848 |
| 115 | Cardiomegaly (HP:0001640) | 1.89322312 |
| 116 | Coxa vara (HP:0002812) | 1.88635157 |
| 117 | Osteomyelitis (HP:0002754) | 1.88433009 |
| 118 | Decreased circulating renin level (HP:0003351) | 1.88285471 |
| 119 | Progressive neurologic deterioration (HP:0002344) | 1.87990104 |
| 120 | Abnormality of T cell number (HP:0011839) | 1.87644753 |
| 121 | Large earlobe (HP:0009748) | 1.87219381 |
| 122 | Personality changes (HP:0000751) | 1.86376407 |
| 123 | Aplasia/Hypoplasia of the phalanges of the toes (HP:0010173) | 1.85670757 |
| 124 | Bone cyst (HP:0012062) | 1.83398611 |
| 125 | Flattened epiphyses (HP:0003071) | 1.83283884 |
| 126 | Abnormal ossification of hand bones (HP:0005921) | 1.82723238 |
| 127 | Absent phalangeal crease (HP:0006109) | 1.80577913 |
| 128 | Vasculitis (HP:0002633) | 1.80066846 |
| 129 | Premature loss of primary teeth (HP:0006323) | 1.79758139 |
| 130 | Malnutrition (HP:0004395) | 1.78236797 |
| 131 | Prolonged neonatal jaundice (HP:0006579) | 1.77545888 |
| 132 | Encephalitis (HP:0002383) | 1.69047881 |
| 133 | Gangrene (HP:0100758) | 1.68533409 |
| 134 | Cheilitis (HP:0100825) | 1.66219820 |
| 135 | Restrictive lung disease (HP:0002091) | 1.64742140 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | MST1R | 5.09563469 |
| 2 | ERN1 | 3.27468071 |
| 3 | RIPK4 | 3.15894244 |
| 4 | BLK | 3.05108164 |
| 5 | TYK2 | 2.96581941 |
| 6 | KIT | 2.92893664 |
| 7 | ACVR1B | 2.86338315 |
| 8 | PIK3CA | 2.68632577 |
| 9 | TBK1 | 2.52065133 |
| 10 | TGFBR2 | 2.48727141 |
| 11 | MAP4K1 | 2.13192042 |
| 12 | TAOK3 | 2.01506967 |
| 13 | CAMK1D | 2.00892686 |
| 14 | CSF1R | 1.95971131 |
| 15 | NME2 | 1.90068674 |
| 16 | CSK | 1.81777701 |
| 17 | MAP2K2 | 1.76382033 |
| 18 | MATK | 1.66967017 |
| 19 | MAP3K14 | 1.66563254 |
| 20 | PRPF4B | 1.63654831 |
| 21 | TRIB3 | 1.58726375 |
| 22 | JAK1 | 1.57617416 |
| 23 | ADRBK2 | 1.55231517 |
| 24 | NEK9 | 1.51341560 |
| 25 | IRAK4 | 1.46757830 |
| 26 | PKN2 | 1.45602719 |
| 27 | PAK4 | 1.45429270 |
| 28 | MET | 1.41104647 |
| 29 | CAMKK2 | 1.39912221 |
| 30 | EPHB1 | 1.38389257 |
| 31 | TTN | 1.38202658 |
| 32 | HCK | 1.35202140 |
| 33 | CAMK1G | 1.32284356 |
| 34 | PTK6 | 1.31859949 |
| 35 | SCYL2 | 1.31057751 |
| 36 | SYK | 1.30643342 |
| 37 | TAOK1 | 1.29546618 |
| 38 | IRAK3 | 1.29087009 |
| 39 | FGR | 1.27095464 |
| 40 | FES | 1.25527339 |
| 41 | CDC42BPA | 1.22602516 |
| 42 | TAOK2 | 1.21988197 |
| 43 | PIM2 | 1.18893030 |
| 44 | MAP3K11 | 1.14020759 |
| 45 | ZAP70 | 1.13411811 |
| 46 | IKBKB | 1.13030602 |
| 47 | LYN | 1.11342788 |
| 48 | MAP3K13 | 1.10172459 |
| 49 | MAP2K3 | 1.09382059 |
| 50 | STK10 | 1.09092615 |
| 51 | IKBKE | 1.08581502 |
| 52 | RIPK1 | 1.05777896 |
| 53 | LCK | 0.99835018 |
| 54 | JAK2 | 0.97721109 |
| 55 | GRK6 | 0.97263470 |
| 56 | ITK | 0.96189901 |
| 57 | MAP3K3 | 0.95104245 |
| 58 | TEC | 0.92465525 |
| 59 | TGFBR1 | 0.90564004 |
| 60 | JAK3 | 0.89483045 |
| 61 | MARK3 | 0.89129482 |
| 62 | MAP3K12 | 0.87864927 |
| 63 | PDK2 | 0.87108216 |
| 64 | TESK1 | 0.87039932 |
| 65 | CDK9 | 0.85933498 |
| 66 | TNK2 | 0.85253195 |
| 67 | MAP2K6 | 0.84973924 |
| 68 | TESK2 | 0.84142398 |
| 69 | CAMKK1 | 0.83154834 |
| 70 | BTK | 0.80936056 |
| 71 | EGFR | 0.77798849 |
| 72 | DAPK2 | 0.77659288 |
| 73 | CDK6 | 0.74101170 |
| 74 | MAP3K8 | 0.73994404 |
| 75 | BRAF | 0.70510265 |
| 76 | PDPK1 | 0.70224510 |
| 77 | NEK2 | 0.69526537 |
| 78 | PDK1 | 0.69415727 |
| 79 | SIK3 | 0.67677974 |
| 80 | MOS | 0.67013737 |
| 81 | LRRK2 | 0.66993342 |
| 82 | GRK7 | 0.66628014 |
| 83 | KSR2 | 0.65559557 |
| 84 | STK24 | 0.65524252 |
| 85 | IRAK2 | 0.65045409 |
| 86 | RPS6KA2 | 0.64058927 |
| 87 | BMPR2 | 0.63519399 |
| 88 | MAP3K9 | 0.62499891 |
| 89 | PRKCD | 0.62318135 |
| 90 | FYN | 0.60188001 |
| 91 | MAP3K1 | 0.59019560 |
| 92 | IRAK1 | 0.58894712 |
| 93 | MAPK7 | 0.58394271 |
| 94 | CLK1 | 0.56942465 |
| 95 | DMPK | 0.56909764 |
| 96 | DDR2 | 0.56413515 |
| 97 | CDK12 | 0.56310061 |
| 98 | DAPK3 | 0.54910567 |
| 99 | MAPK12 | 0.54527858 |
| 100 | FGFR3 | 0.51128928 |
| 101 | ARAF | 0.50949547 |
| 102 | PDGFRB | 0.50882725 |
| 103 | FGFR4 | 0.50249066 |
| 104 | RPS6KA6 | 0.49511148 |
| 105 | RPS6KL1 | 0.48733577 |
| 106 | RPS6KC1 | 0.48733577 |
| 107 | ABL1 | 0.48427324 |
| 108 | SIK2 | 0.48237340 |
| 109 | TXK | 0.45829425 |
| 110 | CHUK | 0.45442712 |
| 111 | EPHB2 | 0.44078434 |
| 112 | ABL2 | 0.43237674 |
| 113 | RPS6KA4 | 0.42501086 |
| 114 | PRKD2 | 0.41524519 |
| 115 | TRPM7 | 0.41009446 |
| 116 | MAP2K1 | 0.40739353 |
| 117 | LIMK1 | 0.40278167 |
| 118 | MAPKAPK3 | 0.40033514 |
| 119 | SRC | 0.39574174 |
| 120 | MARK2 | 0.39310692 |
| 121 | FRK | 0.38553549 |
| 122 | MAPKAPK2 | 0.38383271 |
| 123 | PIM1 | 0.37547510 |
| 124 | MAP3K6 | 0.37230161 |
| 125 | IGF1R | 0.37120891 |
| 126 | MAP3K2 | 0.36914414 |
| 127 | PRKCH | 0.36430542 |
| 128 | PRKCQ | 0.35911560 |
| 129 | ICK | 0.35853545 |
| 130 | PRKG2 | 0.34876229 |
| 131 | MAP3K5 | 0.33885365 |
| 132 | DYRK1B | 0.33385827 |
| 133 | KSR1 | 0.30560878 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | Glycosaminoglycan degradation_Homo sapiens_hsa00531 | 4.28748903 |
| 2 | Sulfur metabolism_Homo sapiens_hsa00920 | 4.28588901 |
| 3 | Lysosome_Homo sapiens_hsa04142 | 3.63199415 |
| 4 | Staphylococcus aureus infection_Homo sapiens_hsa05150 | 3.33927374 |
| 5 | Sulfur relay system_Homo sapiens_hsa04122 | 3.08094033 |
| 6 | Other glycan degradation_Homo sapiens_hsa00511 | 2.98794104 |
| 7 | Osteoclast differentiation_Homo sapiens_hsa04380 | 2.39950664 |
| 8 | Leishmaniasis_Homo sapiens_hsa05140 | 2.39434927 |
| 9 | Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603 | 2.36231894 |
| 10 | Toll-like receptor signaling pathway_Homo sapiens_hsa04620 | 2.29044379 |
| 11 | Autoimmune thyroid disease_Homo sapiens_hsa05320 | 2.19134879 |
| 12 | Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604 | 1.97511734 |
| 13 | Tuberculosis_Homo sapiens_hsa05152 | 1.96135930 |
| 14 | B cell receptor signaling pathway_Homo sapiens_hsa04662 | 1.95251674 |
| 15 | Pertussis_Homo sapiens_hsa05133 | 1.94135197 |
| 16 | Type I diabetes mellitus_Homo sapiens_hsa04940 | 1.87735417 |
| 17 | Butirosin and neomycin biosynthesis_Homo sapiens_hsa00524 | 1.79676705 |
| 18 | Phagosome_Homo sapiens_hsa04145 | 1.78943417 |
| 19 | Antigen processing and presentation_Homo sapiens_hsa04612 | 1.70975382 |
| 20 | Mineral absorption_Homo sapiens_hsa04978 | 1.66652277 |
| 21 | Fc gamma R-mediated phagocytosis_Homo sapiens_hsa04666 | 1.57295137 |
| 22 | NF-kappa B signaling pathway_Homo sapiens_hsa04064 | 1.43493498 |
| 23 | Malaria_Homo sapiens_hsa05144 | 1.42155827 |
| 24 | Legionellosis_Homo sapiens_hsa05134 | 1.38796922 |
| 25 | Rheumatoid arthritis_Homo sapiens_hsa05323 | 1.34096372 |
| 26 | Chagas disease (American trypanosomiasis)_Homo sapiens_hsa05142 | 1.30639654 |
| 27 | Salmonella infection_Homo sapiens_hsa05132 | 1.26349810 |
| 28 | Pentose and glucuronate interconversions_Homo sapiens_hsa00040 | 1.25637918 |
| 29 | Apoptosis_Homo sapiens_hsa04210 | 1.22259356 |
| 30 | Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa00520 | 1.20315235 |
| 31 | Caffeine metabolism_Homo sapiens_hsa00232 | 1.18457302 |
| 32 | Intestinal immune network for IgA production_Homo sapiens_hsa04672 | 1.17392056 |
| 33 | Toxoplasmosis_Homo sapiens_hsa05145 | 1.16020604 |
| 34 | Influenza A_Homo sapiens_hsa05164 | 1.14577759 |
| 35 | Natural killer cell mediated cytotoxicity_Homo sapiens_hsa04650 | 1.14555142 |
| 36 | Fc epsilon RI signaling pathway_Homo sapiens_hsa04664 | 1.14134368 |
| 37 | Measles_Homo sapiens_hsa05162 | 1.13920070 |
| 38 | Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072 | 1.10686286 |
| 39 | Leukocyte transendothelial migration_Homo sapiens_hsa04670 | 1.06546712 |
| 40 | Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321 | 1.02076226 |
| 41 | Bacterial invasion of epithelial cells_Homo sapiens_hsa05100 | 1.01736792 |
| 42 | NOD-like receptor signaling pathway_Homo sapiens_hsa04621 | 0.95342513 |
| 43 | Sphingolipid metabolism_Homo sapiens_hsa00600 | 0.95275136 |
| 44 | Shigellosis_Homo sapiens_hsa05131 | 0.95035927 |
| 45 | Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa00532 | 0.94652781 |
| 46 | Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa05120 | 0.93511543 |
| 47 | RIG-I-like receptor signaling pathway_Homo sapiens_hsa04622 | 0.92234389 |
| 48 | Prion diseases_Homo sapiens_hsa05020 | 0.86371570 |
| 49 | Chemokine signaling pathway_Homo sapiens_hsa04062 | 0.85145315 |
| 50 | Complement and coagulation cascades_Homo sapiens_hsa04610 | 0.83079691 |
| 51 | Collecting duct acid secretion_Homo sapiens_hsa04966 | 0.82103353 |
| 52 | TNF signaling pathway_Homo sapiens_hsa04668 | 0.81304415 |
| 53 | Chronic myeloid leukemia_Homo sapiens_hsa05220 | 0.77691752 |
| 54 | Hematopoietic cell lineage_Homo sapiens_hsa04640 | 0.77550846 |
| 55 | Hepatitis B_Homo sapiens_hsa05161 | 0.76610958 |
| 56 | Hepatitis C_Homo sapiens_hsa05160 | 0.74215308 |
| 57 | Primary bile acid biosynthesis_Homo sapiens_hsa00120 | 0.72593985 |
| 58 | Pathogenic Escherichia coli infection_Homo sapiens_hsa05130 | 0.68508954 |
| 59 | Vibrio cholerae infection_Homo sapiens_hsa05110 | 0.65621902 |
| 60 | Endocytosis_Homo sapiens_hsa04144 | 0.65123216 |
| 61 | Fat digestion and absorption_Homo sapiens_hsa04975 | 0.65016596 |
| 62 | Fructose and mannose metabolism_Homo sapiens_hsa00051 | 0.64855321 |
| 63 | T cell receptor signaling pathway_Homo sapiens_hsa04660 | 0.62683023 |
| 64 | Primary immunodeficiency_Homo sapiens_hsa05340 | 0.62623787 |
| 65 | Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512 | 0.60697070 |
| 66 | alpha-Linolenic acid metabolism_Homo sapiens_hsa00592 | 0.60594229 |
| 67 | Galactose metabolism_Homo sapiens_hsa00052 | 0.59405727 |
| 68 | Cell adhesion molecules (CAMs)_Homo sapiens_hsa04514 | 0.59002889 |
| 69 | Sphingolipid signaling pathway_Homo sapiens_hsa04071 | 0.57788802 |
| 70 | Ascorbate and aldarate metabolism_Homo sapiens_hsa00053 | 0.57600623 |
| 71 | Viral myocarditis_Homo sapiens_hsa05416 | 0.56741935 |
| 72 | Pancreatic cancer_Homo sapiens_hsa05212 | 0.56090149 |
| 73 | Platelet activation_Homo sapiens_hsa04611 | 0.55874965 |
| 74 | Renin-angiotensin system_Homo sapiens_hsa04614 | 0.53879324 |
| 75 | Acute myeloid leukemia_Homo sapiens_hsa05221 | 0.53748530 |
| 76 | Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623 | 0.53435484 |
| 77 | Amoebiasis_Homo sapiens_hsa05146 | 0.51144555 |
| 78 | Jak-STAT signaling pathway_Homo sapiens_hsa04630 | 0.50885723 |
| 79 | African trypanosomiasis_Homo sapiens_hsa05143 | 0.49451461 |
| 80 | Allograft rejection_Homo sapiens_hsa05330 | 0.49395620 |
| 81 | Bladder cancer_Homo sapiens_hsa05219 | 0.48591935 |
| 82 | AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa04933 | 0.48005396 |
| 83 | Graft-versus-host disease_Homo sapiens_hsa05332 | 0.47877253 |
| 84 | Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060 | 0.47656488 |
| 85 | PPAR signaling pathway_Homo sapiens_hsa03320 | 0.47364977 |
| 86 | SNARE interactions in vesicular transport_Homo sapiens_hsa04130 | 0.46992560 |
| 87 | Carbohydrate digestion and absorption_Homo sapiens_hsa04973 | 0.46173481 |
| 88 | Regulation of actin cytoskeleton_Homo sapiens_hsa04810 | 0.44860104 |
| 89 | VEGF signaling pathway_Homo sapiens_hsa04370 | 0.42510505 |
| 90 | Adipocytokine signaling pathway_Homo sapiens_hsa04920 | 0.42225965 |
| 91 | Herpes simplex infection_Homo sapiens_hsa05168 | 0.41475680 |
| 92 | Asthma_Homo sapiens_hsa05310 | 0.39678079 |
| 93 | Ether lipid metabolism_Homo sapiens_hsa00565 | 0.39005583 |
| 94 | Proteoglycans in cancer_Homo sapiens_hsa05205 | 0.38675369 |
| 95 | HIF-1 signaling pathway_Homo sapiens_hsa04066 | 0.37642302 |
| 96 | Linoleic acid metabolism_Homo sapiens_hsa00591 | 0.34447282 |
| 97 | Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa04960 | 0.33891561 |
| 98 | ABC transporters_Homo sapiens_hsa02010 | 0.33413236 |
| 99 | Neurotrophin signaling pathway_Homo sapiens_hsa04722 | 0.33241529 |
| 100 | Tryptophan metabolism_Homo sapiens_hsa00380 | 0.33002132 |
| 101 | GnRH signaling pathway_Homo sapiens_hsa04912 | 0.31593388 |
| 102 | Prolactin signaling pathway_Homo sapiens_hsa04917 | 0.30723364 |
| 103 | Glycerolipid metabolism_Homo sapiens_hsa00561 | 0.30164583 |
| 104 | Steroid biosynthesis_Homo sapiens_hsa00100 | 0.29894177 |
| 105 | Epstein-Barr virus infection_Homo sapiens_hsa05169 | 0.28353126 |
| 106 | Arachidonic acid metabolism_Homo sapiens_hsa00590 | 0.27975314 |
| 107 | Ovarian steroidogenesis_Homo sapiens_hsa04913 | 0.27912587 |
| 108 | Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932 | 0.27007653 |
| 109 | Renal cell carcinoma_Homo sapiens_hsa05211 | 0.25813436 |
| 110 | Glycerophospholipid metabolism_Homo sapiens_hsa00564 | 0.24637054 |
| 111 | Histidine metabolism_Homo sapiens_hsa00340 | 0.23275648 |
| 112 | Starch and sucrose metabolism_Homo sapiens_hsa00500 | 0.22447088 |
| 113 | Dorso-ventral axis formation_Homo sapiens_hsa04320 | 0.21826917 |
| 114 | Phospholipase D signaling pathway_Homo sapiens_hsa04072 | 0.21704006 |
| 115 | Type II diabetes mellitus_Homo sapiens_hsa04930 | 0.20688644 |
| 116 | Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa05014 | 0.20143259 |
| 117 | Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601 | 0.19167014 |
| 118 | Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa04750 | 0.18032718 |
| 119 | Systemic lupus erythematosus_Homo sapiens_hsa05322 | 0.17493041 |
| 120 | Insulin resistance_Homo sapiens_hsa04931 | 0.15519892 |
| 121 | Synaptic vesicle cycle_Homo sapiens_hsa04721 | 0.15295050 |

