SLC37A3

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1COPI coating of Golgi vesicle (GO:0048205)5.29716848
2Golgi transport vesicle coating (GO:0048200)5.29716848
3behavioral response to nicotine (GO:0035095)4.73699599
4kynurenine metabolic process (GO:0070189)4.23448569
5nonmotile primary cilium assembly (GO:0035058)3.85814698
6pyrimidine nucleobase catabolic process (GO:0006208)3.71054646
7epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)3.68133759
8regulation of hippo signaling (GO:0035330)3.67689768
9indole-containing compound catabolic process (GO:0042436)3.64341338
10indolalkylamine catabolic process (GO:0046218)3.64341338
11tryptophan catabolic process (GO:0006569)3.64341338
12retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)3.56464196
13maintenance of protein localization in endoplasmic reticulum (GO:0035437)3.52666674
14kidney morphogenesis (GO:0060993)3.50841666
15fucose catabolic process (GO:0019317)3.46712722
16L-fucose metabolic process (GO:0042354)3.46712722
17L-fucose catabolic process (GO:0042355)3.46712722
18inner ear receptor cell development (GO:0060119)3.33396261
19protein retention in ER lumen (GO:0006621)3.32310726
20cerebellar Purkinje cell layer development (GO:0021680)3.30720029
21vesicle coating (GO:0006901)3.24622067
22positive regulation of calcium ion-dependent exocytosis (GO:0045956)3.23795480
23maturation of 5.8S rRNA (GO:0000460)3.22628747
24indolalkylamine metabolic process (GO:0006586)3.17655663
25glutamate secretion (GO:0014047)3.16339109
26nucleobase catabolic process (GO:0046113)3.11905398
27regulation of gene silencing by RNA (GO:0060966)3.09112907
28regulation of posttranscriptional gene silencing (GO:0060147)3.09112907
29regulation of gene silencing by miRNA (GO:0060964)3.09112907
30response to pheromone (GO:0019236)3.08995985
31respiratory chain complex IV assembly (GO:0008535)3.07807303
32regulation of cilium movement (GO:0003352)3.05786189
33DNA deamination (GO:0045006)3.03743416
34proline transport (GO:0015824)3.03433004
35activation of signaling protein activity involved in unfolded protein response (GO:0006987)3.00545983
36tryptophan metabolic process (GO:0006568)3.00379950
37COPII vesicle coating (GO:0048208)2.98722092
38layer formation in cerebral cortex (GO:0021819)2.96317451
39regulation of short-term neuronal synaptic plasticity (GO:0048172)2.95395109
40gamma-aminobutyric acid transport (GO:0015812)2.94577002
41piRNA metabolic process (GO:0034587)2.91256074
42cornea development in camera-type eye (GO:0061303)2.89404323
43photoreceptor cell maintenance (GO:0045494)2.87076139
44presynaptic membrane assembly (GO:0097105)2.85960302
45synaptic vesicle maturation (GO:0016188)2.85569294
46synaptic vesicle docking involved in exocytosis (GO:0016081)2.83620849
47epithelial cilium movement (GO:0003351)2.83563070
48axonal fasciculation (GO:0007413)2.81837367
49synaptic vesicle exocytosis (GO:0016079)2.81467408
50axon extension involved in axon guidance (GO:0048846)2.81007172
51neuron projection extension involved in neuron projection guidance (GO:1902284)2.81007172
52cilium morphogenesis (GO:0060271)2.80490388
53dendrite morphogenesis (GO:0048813)2.80396792
54insulin-like growth factor receptor signaling pathway (GO:0048009)2.80369472
55detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)2.80153640
56vocalization behavior (GO:0071625)2.78830219
57cilium organization (GO:0044782)2.76650636
58positive regulation of nuclease activity (GO:0032075)2.76293271
59regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)2.72256078
60regulation of mitotic spindle checkpoint (GO:1903504)2.72256078
61preassembly of GPI anchor in ER membrane (GO:0016254)2.70713310
62cytochrome complex assembly (GO:0017004)2.70216719
63locomotory exploration behavior (GO:0035641)2.68868167
64negative regulation of cytosolic calcium ion concentration (GO:0051481)2.66929979
65cilium assembly (GO:0042384)2.65674856
66innervation (GO:0060384)2.64369107
67retinal ganglion cell axon guidance (GO:0031290)2.63672413
68cell migration in hindbrain (GO:0021535)2.63410250
69regulation of synaptic vesicle exocytosis (GO:2000300)2.62685759
70alanine transport (GO:0032328)2.61386826
71mannosylation (GO:0097502)2.59774856
72establishment of nucleus localization (GO:0040023)2.59485758
73peptidyl-histidine modification (GO:0018202)2.58689922
74neuron recognition (GO:0008038)2.56702266
75axoneme assembly (GO:0035082)2.56022473
76pseudouridine synthesis (GO:0001522)2.55600377
77negative regulation of translation involved in gene silencing by miRNA (GO:0035278)2.55110839
78negative regulation of translation, ncRNA-mediated (GO:0040033)2.55110839
79regulation of translation, ncRNA-mediated (GO:0045974)2.55110839
80amine catabolic process (GO:0009310)2.54492709
81cellular biogenic amine catabolic process (GO:0042402)2.54492709
82axon extension (GO:0048675)2.53528287
83regulation of synapse structural plasticity (GO:0051823)2.53027401
84protein polyglutamylation (GO:0018095)2.52674051
85apical protein localization (GO:0045176)2.51063457
86neural tube formation (GO:0001841)2.49158669
87behavioral response to ethanol (GO:0048149)2.49038273
88reciprocal DNA recombination (GO:0035825)2.48873270
89reciprocal meiotic recombination (GO:0007131)2.48873270
90water-soluble vitamin biosynthetic process (GO:0042364)2.48250715
91endocrine pancreas development (GO:0031018)2.47921881
92detection of light stimulus involved in visual perception (GO:0050908)2.46551073
93detection of light stimulus involved in sensory perception (GO:0050962)2.46551073
94positive regulation of synapse maturation (GO:0090129)2.46524364
95retinal cone cell development (GO:0046549)2.46464794
96presynaptic membrane organization (GO:0097090)2.45512489
97cilium movement (GO:0003341)2.43933764
98regulation of nuclease activity (GO:0032069)2.43384446
99calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules (GO:0016339)2.43283510
100ER-nucleus signaling pathway (GO:0006984)2.42830861
101endoplasmic reticulum unfolded protein response (GO:0030968)2.42342628
102dendritic spine morphogenesis (GO:0060997)2.41935644
103regulation of mesoderm development (GO:2000380)2.41787918
104somite development (GO:0061053)2.41024720
105intestinal epithelial cell development (GO:0060576)2.40445368
106olfactory bulb development (GO:0021772)2.40431902
107platelet dense granule organization (GO:0060155)2.39052526
108macroautophagy (GO:0016236)2.38646566
1094-hydroxyproline metabolic process (GO:0019471)2.38105948
110DNA methylation involved in gamete generation (GO:0043046)2.37901293
111rRNA catabolic process (GO:0016075)2.36727265
112indole-containing compound metabolic process (GO:0042430)2.36021009
113cell junction maintenance (GO:0034331)2.35347972
114negative regulation of telomere maintenance (GO:0032205)2.34597848
115reflex (GO:0060004)2.33785182
116cellular response to unfolded protein (GO:0034620)2.32344668
117neuron projection extension (GO:1990138)2.32251721
118regulation of meiosis I (GO:0060631)2.32127208
119regulation of Wnt signaling pathway, planar cell polarity pathway (GO:2000095)2.31705201
120regulation of glucokinase activity (GO:0033131)2.31332425
121regulation of hexokinase activity (GO:1903299)2.31332425
122regulation of microtubule-based movement (GO:0060632)2.30874391
123positive regulation of mitochondrial fission (GO:0090141)2.30766090
124synapsis (GO:0007129)2.30452509
125positive regulation of guanylate cyclase activity (GO:0031284)2.29594131
126RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)2.29115455
127central nervous system projection neuron axonogenesis (GO:0021952)2.28180572
128phasic smooth muscle contraction (GO:0014821)2.28164534
129dorsal/ventral axis specification (GO:0009950)2.28140452
130regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act2.27828591
131ubiquinone metabolic process (GO:0006743)2.27403055
132limb development (GO:0060173)2.26057493
133appendage development (GO:0048736)2.26057493
134positive regulation of glycogen biosynthetic process (GO:0045725)2.25000572
135intraciliary transport (GO:0042073)2.24950661
136neurotransmitter secretion (GO:0007269)2.24453191
137positive regulation of sodium ion transmembrane transport (GO:1902307)2.24185096
138inner ear receptor stereocilium organization (GO:0060122)2.24171574
139regulation of female receptivity (GO:0045924)2.23329365
140cellular response to topologically incorrect protein (GO:0035967)2.22157597
141regulation of glutamate receptor signaling pathway (GO:1900449)2.21950205
142UDP-N-acetylglucosamine metabolic process (GO:0006047)2.21949511
143isoprenoid biosynthetic process (GO:0008299)2.21639443
144oxidative demethylation (GO:0070989)2.21342056
145regulation of rhodopsin mediated signaling pathway (GO:0022400)2.21047193
146arginine catabolic process (GO:0006527)2.19342273
147establishment of planar polarity (GO:0001736)2.18774946
148establishment of tissue polarity (GO:0007164)2.18774946
149smoothened signaling pathway (GO:0007224)2.18662939
150exocrine pancreas development (GO:0031017)2.18102174
151rhodopsin mediated signaling pathway (GO:0016056)2.16591578
152female mating behavior (GO:0060180)2.16412307
153type B pancreatic cell development (GO:0003323)2.16131274
154photoreceptor cell development (GO:0042461)2.16110552
155regulation of synaptic vesicle transport (GO:1902803)2.15565402
156positive regulation of vesicle fusion (GO:0031340)2.15243023
157protein localization to synapse (GO:0035418)2.14766492
158magnesium ion transport (GO:0015693)2.14708423
159homophilic cell adhesion via plasma membrane adhesion molecules (GO:0007156)2.14120182
160dendritic spine organization (GO:0097061)2.13149829
161L-phenylalanine catabolic process (GO:0006559)2.11942702
162erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)2.11942702
163neuron cell-cell adhesion (GO:0007158)2.11261431
164activation of protein kinase A activity (GO:0034199)2.08685834
165polarized epithelial cell differentiation (GO:0030859)2.08303057
166chondrocyte development (GO:0002063)2.08227595
167negative regulation of axon extension involved in axon guidance (GO:0048843)2.07968758
168anterior/posterior axis specification, embryo (GO:0008595)2.07700960
169peptide hormone processing (GO:0016486)2.06628553
170regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)2.05852879
171regulation of vascular endothelial growth factor signaling pathway (GO:1900746)2.05777508
172regulation of neuron migration (GO:2001222)2.05086921
173neurotransmitter-gated ion channel clustering (GO:0072578)2.04513032
174regulation of cholesterol homeostasis (GO:2000188)2.04442843
175insulin secretion (GO:0030073)2.04197894
176response to endoplasmic reticulum stress (GO:0034976)2.03544504
177erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)2.03115581
178L-phenylalanine metabolic process (GO:0006558)2.03115581
179regulation of axon extension involved in axon guidance (GO:0048841)2.03112468
180collagen fibril organization (GO:0030199)2.02410406
181cell communication by electrical coupling (GO:0010644)2.01951507
182cellular ketone body metabolic process (GO:0046950)2.01725666
183keratan sulfate catabolic process (GO:0042340)2.00843823
184regulation of neuronal synaptic plasticity (GO:0048168)2.00420667
185columnar/cuboidal epithelial cell development (GO:0002066)2.00133022
186ER overload response (GO:0006983)2.00069844
187cell-cell junction maintenance (GO:0045217)1.99722472
188protein maturation by protein folding (GO:0022417)1.99320511
189ephrin receptor signaling pathway (GO:0048013)1.98421885
190glandular epithelial cell development (GO:0002068)1.98299691
191membrane repolarization during cardiac muscle cell action potential (GO:0086013)1.97561485
192glial cell proliferation (GO:0014009)1.97328160
193regulation of long-term neuronal synaptic plasticity (GO:0048169)1.97178754
194negative regulation of catenin import into nucleus (GO:0035414)1.97167729
195intestinal cholesterol absorption (GO:0030299)1.96548318
196protein carboxylation (GO:0018214)1.96342890
197peptidyl-glutamic acid carboxylation (GO:0017187)1.96342890

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human3.49518891
2SALL1_21062744_ChIP-ChIP_HESCs_Human3.03067185
3ZFP57_27257070_Chip-Seq_ESCs_Mouse2.75623065
4TRIM28_21343339_ChIP-Seq_HEK293_Human2.64242408
5POU3F2_20337985_ChIP-ChIP_501MEL_Human2.35066348
6VDR_22108803_ChIP-Seq_LS180_Human2.31261922
7FUS_26573619_Chip-Seq_HEK293_Human2.30899936
8EWS_26573619_Chip-Seq_HEK293_Human2.21233280
9IGF1R_20145208_ChIP-Seq_DFB_Human2.20288860
10SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.13220164
11P300_19829295_ChIP-Seq_ESCs_Human2.10032094
12TAF15_26573619_Chip-Seq_HEK293_Human2.09794998
13GBX2_23144817_ChIP-Seq_PC3_Human2.08287853
14RBPJ_22232070_ChIP-Seq_NCS_Mouse2.08118548
15SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.02011427
16EZH2_18974828_ChIP-Seq_MESCs_Mouse1.99910813
17RNF2_18974828_ChIP-Seq_MESCs_Mouse1.99910813
18SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.93170512
19HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.91370317
20ZNF217_24962896_ChIP-Seq_MCF-7_Human1.89021697
21TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.82148994
22CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.81804072
23EED_16625203_ChIP-ChIP_MESCs_Mouse1.80962544
24SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.80149596
25CLOCK_20551151_ChIP-Seq_293T_Human1.79772155
26NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.78720428
27GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.78286135
28SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.72786609
29JARID2_20075857_ChIP-Seq_MESCs_Mouse1.72562105
30JARID2_20064375_ChIP-Seq_MESCs_Mouse1.72005379
31SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.71161136
32ERG_21242973_ChIP-ChIP_JURKAT_Human1.69829478
33ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.68004370
34FLI1_27457419_Chip-Seq_LIVER_Mouse1.67666335
35MTF2_20144788_ChIP-Seq_MESCs_Mouse1.66710652
36RNF2_27304074_Chip-Seq_NSC_Mouse1.64471597
37EZH2_27304074_Chip-Seq_ESCs_Mouse1.63663458
38ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.61391683
39NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.61193030
40BMI1_23680149_ChIP-Seq_NPCS_Mouse1.58508385
41RARB_27405468_Chip-Seq_BRAIN_Mouse1.58497635
42SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.55369171
43WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.55192215
44ER_23166858_ChIP-Seq_MCF-7_Human1.55118975
45ZFP281_18757296_ChIP-ChIP_E14_Mouse1.53667305
46GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.53439993
47DROSHA_22980978_ChIP-Seq_HELA_Human1.53179063
48NR3C1_21868756_ChIP-Seq_MCF10A_Human1.52882902
49RNF2_27304074_Chip-Seq_ESCs_Mouse1.52214211
50MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.52094352
51EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.51493438
52TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.51080323
53CBX2_27304074_Chip-Seq_ESCs_Mouse1.50113543
54MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.49833143
55UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.48187558
56ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.48040604
57PCGF2_27294783_Chip-Seq_ESCs_Mouse1.47062391
58TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.45660930
59TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.44996870
60BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.44692160
61IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.44457258
62CBP_20019798_ChIP-Seq_JUKART_Human1.44457258
63EZH2_27294783_Chip-Seq_ESCs_Mouse1.43772760
64* TCF4_23295773_ChIP-Seq_U87_Human1.42762664
65KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.42154786
66POU5F1_16153702_ChIP-ChIP_HESCs_Human1.41912154
67AR_25329375_ChIP-Seq_VCAP_Human1.41888655
68* REST_21632747_ChIP-Seq_MESCs_Mouse1.40820157
69PIAS1_25552417_ChIP-Seq_VCAP_Human1.38333008
70GABP_17652178_ChIP-ChIP_JURKAT_Human1.37865900
71CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.37677858
72MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.37340453
73* LXR_22158963_ChIP-Seq_LIVER_Mouse1.36906629
74AR_21572438_ChIP-Seq_LNCaP_Human1.36793551
75ESR1_21235772_ChIP-Seq_MCF-7_Human1.36620352
76EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.36543889
77SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.36323478
78* TCF4_22108803_ChIP-Seq_LS180_Human1.35895099
79SUZ12_27294783_Chip-Seq_ESCs_Mouse1.34435588
80TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.34392385
81POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.34392385
82AHR_22903824_ChIP-Seq_MCF-7_Human1.31946940
83* ESR2_21235772_ChIP-Seq_MCF-7_Human1.31010425
84CTBP2_25329375_ChIP-Seq_LNCAP_Human1.30910390
85* REST_18959480_ChIP-ChIP_MESCs_Mouse1.28808514
86RXR_22158963_ChIP-Seq_LIVER_Mouse1.28488018
87TP53_22573176_ChIP-Seq_HFKS_Human1.27366059
88KLF5_20875108_ChIP-Seq_MESCs_Mouse1.26401353
89RING1B_27294783_Chip-Seq_NPCs_Mouse1.24714836
90WT1_19549856_ChIP-ChIP_CCG9911_Human1.24664638
91ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.24218995
92RUNX2_22187159_ChIP-Seq_PCA_Human1.23998556
93KDM2B_26808549_Chip-Seq_K562_Human1.23685054
94* ARNT_22903824_ChIP-Seq_MCF-7_Human1.22716541
95EP300_21415370_ChIP-Seq_HL-1_Mouse1.21012062
96WT1_25993318_ChIP-Seq_PODOCYTE_Human1.20336402
97MYC_18940864_ChIP-ChIP_HL60_Human1.19811797
98KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.19258004
99AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.18707324
100* SOX2_21211035_ChIP-Seq_LN229_Gbm1.18678747
101NR3C1_23031785_ChIP-Seq_PC12_Mouse1.17218182
102ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.17025145
103SMAD4_21741376_ChIP-Seq_EPCs_Human1.15385137
104SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.15126389
105SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.15121522
106* DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.13249401
107RARG_19884340_ChIP-ChIP_MEFs_Mouse1.12139480
108NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.11699235
109NRF2_20460467_ChIP-Seq_MEFs_Mouse1.11699235
110JUN_21703547_ChIP-Seq_K562_Human1.11392641
111MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.10676525
112STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse1.10381452
113PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.09844049
114* GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.09637301
115IRF1_19129219_ChIP-ChIP_H3396_Human1.08919061
116ESR1_20079471_ChIP-ChIP_T-47D_Human1.08541864
117RING1B_27294783_Chip-Seq_ESCs_Mouse1.08136042
118ELK1_19687146_ChIP-ChIP_HELA_Human1.07948606
119AR_19668381_ChIP-Seq_PC3_Human1.07782145
120FOXA1_27270436_Chip-Seq_PROSTATE_Human1.07515194
121FOXA1_25329375_ChIP-Seq_VCAP_Human1.07515194
122SMAD4_21799915_ChIP-Seq_A2780_Human1.07340961
123ZFP281_27345836_Chip-Seq_ESCs_Mouse1.06995807
124NANOG_19829295_ChIP-Seq_ESCs_Human1.06688554
125SOX2_19829295_ChIP-Seq_ESCs_Human1.06688554
126NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.06434535
127SOX2_18358816_ChIP-ChIP_MESCs_Mouse1.05405050
128TOP2B_26459242_ChIP-Seq_MCF-7_Human1.04938748
129PPARA_22158963_ChIP-Seq_LIVER_Mouse1.04896528
130FOXA2_19822575_ChIP-Seq_HepG2_Human1.04836777
131DNAJC2_21179169_ChIP-ChIP_NT2_Human1.03828222
132CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.03551669
133PCGF2_27294783_Chip-Seq_NPCs_Mouse1.03507697
134* FOXA1_21572438_ChIP-Seq_LNCaP_Human1.03344665
135FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.03333383
136HOXB7_26014856_ChIP-Seq_BT474_Human1.02797381
137YAP1_20516196_ChIP-Seq_MESCs_Mouse1.02226262
138CDX2_22108803_ChIP-Seq_LS180_Human1.01051704
139FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse1.00524492
140ISL1_27105846_Chip-Seq_CPCs_Mouse0.99759481
141OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.99681848
142CDX2_19796622_ChIP-Seq_MESCs_Mouse0.99548086
143SUZ12_27294783_Chip-Seq_NPCs_Mouse0.98710364
144* SMAD4_21741376_ChIP-Seq_HESCs_Human0.98497696
145SMAD3_21741376_ChIP-Seq_EPCs_Human0.98248500
146EZH2_27294783_Chip-Seq_NPCs_Mouse0.98060012
147TP53_18474530_ChIP-ChIP_U2OS_Human0.97896609
148ZNF274_21170338_ChIP-Seq_K562_Hela0.97474432
149CTBP1_25329375_ChIP-Seq_LNCAP_Human0.97322036
150* OLIG2_26023283_ChIP-Seq_AINV15_Mouse0.96603253
151TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.96407876
152TP53_20018659_ChIP-ChIP_R1E_Mouse0.96358526
153SMARCD1_25818293_ChIP-Seq_ESCs_Mouse0.96241386
154* ETV2_25802403_ChIP-Seq_MESCs_Mouse0.95982922
155STAT3_23295773_ChIP-Seq_U87_Human0.95927777
156TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse0.95341947
157NOTCH1_21737748_ChIP-Seq_TLL_Human0.95318442
158* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human0.94811018
159RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse0.94021188
160PHC1_16625203_ChIP-ChIP_MESCs_Mouse0.93994992
161BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.93678560
162SOX2_27498859_Chip-Seq_STOMACH_Mouse0.93446874
163AUTS2_25519132_ChIP-Seq_293T-REX_Human0.93269777
164BCAT_22108803_ChIP-Seq_LS180_Human0.92565482
165SMAD3_21741376_ChIP-Seq_ESCs_Human0.92470984
166PRDM14_20953172_ChIP-Seq_ESCs_Human0.92434893
167STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse0.92045026
168RNF2_16625203_ChIP-ChIP_MESCs_Mouse0.92026884
169ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.91702575
170TAL1_26923725_Chip-Seq_HPCs_Mouse0.91450736
171TRIM28_17542650_ChIP-ChIP_NTERA2_Human0.91182171
172AR_20517297_ChIP-Seq_VCAP_Human0.90948919
173NANOG_18555785_Chip-Seq_ESCs_Mouse0.90910527

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0009780_abnormal_chondrocyte_physiolo3.83407044
2MP0003283_abnormal_digestive_organ3.03667593
3MP0004859_abnormal_synaptic_plasticity2.99875210
4MP0003136_yellow_coat_color2.91983581
5MP0000569_abnormal_digit_pigmentation2.49813277
6MP0003705_abnormal_hypodermis_morpholog2.43548445
7MP0008438_abnormal_cutaneous_collagen2.39784807
8MP0008877_abnormal_DNA_methylation2.34924379
9MP0002138_abnormal_hepatobiliary_system2.28254456
10MP0002909_abnormal_adrenal_gland2.25123923
11MP0008875_abnormal_xenobiotic_pharmacok2.22567386
12MP0006276_abnormal_autonomic_nervous2.14556142
13MP0002102_abnormal_ear_morphology2.12139415
14MP0004270_analgesia2.10804009
15MP0002139_abnormal_hepatobiliary_system2.03142929
16MP0002938_white_spotting1.98690814
17MP0005503_abnormal_tendon_morphology1.95966335
18MP0004043_abnormal_pH_regulation1.90965142
19MP0004858_abnormal_nervous_system1.88989341
20MP0001299_abnormal_eye_distance/1.86740607
21MP0003937_abnormal_limbs/digits/tail_de1.83190282
22MP0002896_abnormal_bone_mineralization1.82484607
23MP0000678_abnormal_parathyroid_gland1.76794317
24MP0003635_abnormal_synaptic_transmissio1.75421454
25MP0005551_abnormal_eye_electrophysiolog1.73254942
26MP0003119_abnormal_digestive_system1.73208962
27MP0005365_abnormal_bile_salt1.72663568
28MP0003880_abnormal_central_pattern1.68447714
29MP0003195_calcinosis1.68374646
30MP0008058_abnormal_DNA_repair1.68123953
31MP0002063_abnormal_learning/memory/cond1.65357700
32MP0002638_abnormal_pupillary_reflex1.63509937
33MP0000778_abnormal_nervous_system1.61398484
34MP0001529_abnormal_vocalization1.60921708
35MP0009046_muscle_twitch1.59305538
36MP0001968_abnormal_touch/_nociception1.58213597
37MP0005645_abnormal_hypothalamus_physiol1.54672835
38MP0004147_increased_porphyrin_level1.51374655
39MP0005360_urolithiasis1.51251316
40MP0003122_maternal_imprinting1.50187417
41MP0000427_abnormal_hair_cycle1.49243277
42MP0000013_abnormal_adipose_tissue1.48934200
43MP0002160_abnormal_reproductive_system1.48890221
44MP0005275_abnormal_skin_tensile1.48858950
45MP0005257_abnormal_intraocular_pressure1.45819578
46MP0003329_amyloid_beta_deposits1.45518276
47MP0005085_abnormal_gallbladder_physiolo1.45499554
48MP0000566_synostosis1.43100787
49MP0000631_abnormal_neuroendocrine_gland1.42686930
50MP0006072_abnormal_retinal_apoptosis1.41559780
51MP0000383_abnormal_hair_follicle1.40332910
52MP0000534_abnormal_ureter_morphology1.39206917
53MP0004142_abnormal_muscle_tone1.37311345
54MP0003646_muscle_fatigue1.37195065
55MP0003718_maternal_effect1.35175071
56MP0004272_abnormal_basement_membrane1.34350007
57MP0004885_abnormal_endolymph1.33490582
58MP0005084_abnormal_gallbladder_morpholo1.31799348
59MP0003121_genomic_imprinting1.31313911
60MP0002837_dystrophic_cardiac_calcinosis1.31078490
61MP0002751_abnormal_autonomic_nervous1.30333626
62MP0005253_abnormal_eye_physiology1.30313300
63MP0008961_abnormal_basal_metabolism1.30222893
64MP0002272_abnormal_nervous_system1.28921826
65MP0001293_anophthalmia1.28524895
66MP0000647_abnormal_sebaceous_gland1.28262338
67MP0002254_reproductive_system_inflammat1.26917687
68MP0003252_abnormal_bile_duct1.26392488
69MP0005646_abnormal_pituitary_gland1.25659099
70MP0001944_abnormal_pancreas_morphology1.24061436
71MP0001188_hyperpigmentation1.21696021
72MP0002734_abnormal_mechanical_nocicepti1.21678188
73MP0008872_abnormal_physiological_respon1.21567751
74MP0003868_abnormal_feces_composition1.21558301
75MP0005220_abnormal_exocrine_pancreas1.21282689
76MP0005187_abnormal_penis_morphology1.20439016
77MP0000537_abnormal_urethra_morphology1.20381070
78MP0002928_abnormal_bile_duct1.18595772
79MP0002572_abnormal_emotion/affect_behav1.17631847
80MP0003942_abnormal_urinary_system1.16175144
81MP0006292_abnormal_olfactory_placode1.15450745
82MP0002736_abnormal_nociception_after1.15295457
83MP0001666_abnormal_nutrient_absorption1.14989693
84MP0001984_abnormal_olfaction1.14626671
85MP0003787_abnormal_imprinting1.14244416
86MP0002735_abnormal_chemical_nociception1.13598088
87MP0002653_abnormal_ependyma_morphology1.13090442
88MP0005386_behavior/neurological_phenoty1.12377759
89MP0004924_abnormal_behavior1.12377759
90MP0005171_absent_coat_pigmentation1.11882960
91MP0002184_abnormal_innervation1.09499805
92MP0005623_abnormal_meninges_morphology1.08874788
93MP0000955_abnormal_spinal_cord1.07671017
94MP0009053_abnormal_anal_canal1.07301264
95MP0002295_abnormal_pulmonary_circulatio1.06680112
96MP0001849_ear_inflammation1.05779139
97MP0002089_abnormal_postnatal_growth/wei1.05645684
98MP0010678_abnormal_skin_adnexa1.05426788
99MP0010386_abnormal_urinary_bladder1.05117153
100MP0003890_abnormal_embryonic-extraembry1.05008278
101MP0002877_abnormal_melanocyte_morpholog1.04975661
102MP0001970_abnormal_pain_threshold1.04907313
103MP0008775_abnormal_heart_ventricle1.04618992
104MP0002233_abnormal_nose_morphology1.04539296
105MP0002752_abnormal_somatic_nervous1.02122270
106MP0005389_reproductive_system_phenotype1.02105985
107MP0003755_abnormal_palate_morphology1.00946895
108MP0000163_abnormal_cartilage_morphology1.00687070
109MP0004134_abnormal_chest_morphology1.00290003
110MP0002064_seizures1.00186931
111MP0009745_abnormal_behavioral_response1.00173815
112MP0005508_abnormal_skeleton_morphology1.00023589
113MP0004133_heterotaxia0.99634232
114MP0004264_abnormal_extraembryonic_tissu0.99181219
115MP0005394_taste/olfaction_phenotype0.99071940
116MP0005499_abnormal_olfactory_system0.99071940
117MP0002282_abnormal_trachea_morphology0.96116039
118MP0005195_abnormal_posterior_eye0.96063917
119MP0004811_abnormal_neuron_physiology0.95655027
120MP0009250_abnormal_appendicular_skeleto0.95178332
121MP0005423_abnormal_somatic_nervous0.95030986
122MP0010368_abnormal_lymphatic_system0.92977530
123MP0003693_abnormal_embryo_hatching0.92901241
124MP0010234_abnormal_vibrissa_follicle0.92593525
125MP0009384_cardiac_valve_regurgitation0.92397152
126MP0003879_abnormal_hair_cell0.91768383
127MP0003115_abnormal_respiratory_system0.91279198
128MP0002116_abnormal_craniofacial_bone0.90929716
129MP0003123_paternal_imprinting0.90209186
130MP0003567_abnormal_fetal_cardiomyocyte0.90207398
131MP0004233_abnormal_muscle_weight0.89978423
132MP0005248_abnormal_Harderian_gland0.89368485
133MP0001286_abnormal_eye_development0.89352649
134MP0003861_abnormal_nervous_system0.88164385
135MP0010329_abnormal_lipoprotein_level0.87637967
136MP0001486_abnormal_startle_reflex0.87167100
137MP0002234_abnormal_pharynx_morphology0.87017451
138MP0001501_abnormal_sleep_pattern0.85997387
139MP0000538_abnormal_urinary_bladder0.85227523
140MP0002876_abnormal_thyroid_physiology0.85033026
141MP0008789_abnormal_olfactory_epithelium0.84789259
142MP0005391_vision/eye_phenotype0.84535147
143MP0003183_abnormal_peptide_metabolism0.83631506
144MP0001324_abnormal_eye_pigmentation0.83426373
145MP0001177_atelectasis0.82671759
146MP0001440_abnormal_grooming_behavior0.80453695
147MP0003935_abnormal_craniofacial_develop0.80346106
148MP0004185_abnormal_adipocyte_glucose0.79975753
149MP0000003_abnormal_adipose_tissue0.79798869
150MP0002078_abnormal_glucose_homeostasis0.79642013
151MP0002557_abnormal_social/conspecific_i0.79217932
152MP0001756_abnormal_urination0.78204421
153MP0003385_abnormal_body_wall0.78199049
154MP0000516_abnormal_urinary_system0.78121695
155MP0005367_renal/urinary_system_phenotyp0.78121695
156MP0002822_catalepsy0.77479954
157MP0001270_distended_abdomen0.77458745
158MP0002152_abnormal_brain_morphology0.75853647
159MP0002115_abnormal_skeleton_extremities0.75477172
160MP0002108_abnormal_muscle_morphology0.75295233
161MP0000049_abnormal_middle_ear0.75087765
162MP0000604_amyloidosis0.75029988
163MP0002733_abnormal_thermal_nociception0.74859916

Predicted human phenotypes

RankGene SetZ-score
1Pancreatic cysts (HP:0001737)4.61896817
2Pancreatic fibrosis (HP:0100732)4.27929206
3Molar tooth sign on MRI (HP:0002419)3.88716530
4Abnormality of midbrain morphology (HP:0002418)3.88716530
5Nephronophthisis (HP:0000090)3.65463045
6True hermaphroditism (HP:0010459)3.63478461
7Type II lissencephaly (HP:0007260)3.55991631
8Abnormality of the renal medulla (HP:0100957)3.32317042
9Cervical subluxation (HP:0003308)3.05610561
10Abnormality of alanine metabolism (HP:0010916)3.00794795
11Hyperalaninemia (HP:0003348)3.00794795
12Abnormality of pyruvate family amino acid metabolism (HP:0010915)3.00794795
13Congenital stationary night blindness (HP:0007642)3.00415404
14Hepatoblastoma (HP:0002884)2.87375707
15Medial flaring of the eyebrow (HP:0010747)2.83542100
16Gait imbalance (HP:0002141)2.79512722
17Tubular atrophy (HP:0000092)2.76520733
18Abnormality of the renal cortex (HP:0011035)2.73679560
19Abnormal biliary tract physiology (HP:0012439)2.73463186
20Bile duct proliferation (HP:0001408)2.73463186
21Cerebellar dysplasia (HP:0007033)2.68475505
22Congenital primary aphakia (HP:0007707)2.68213839
23Turricephaly (HP:0000262)2.62454731
24Cystic liver disease (HP:0006706)2.60409911
25Lissencephaly (HP:0001339)2.50632923
26Epiphyseal dysplasia (HP:0002656)2.48203714
27Visual hallucinations (HP:0002367)2.46623985
28Pendular nystagmus (HP:0012043)2.46331934
29Sclerocornea (HP:0000647)2.44428204
30Occipital encephalocele (HP:0002085)2.43789101
31Protrusio acetabuli (HP:0003179)2.43306117
32Hyperglycemia (HP:0003074)2.41975572
33Genital tract atresia (HP:0001827)2.41961032
34Hyperinsulinemic hypoglycemia (HP:0000825)2.41889551
35Birth length less than 3rd percentile (HP:0003561)2.40008081
36Nephrogenic diabetes insipidus (HP:0009806)2.39400676
37Cerebral inclusion bodies (HP:0100314)2.37030687
38Fibular aplasia (HP:0002990)2.35226860
39Vaginal atresia (HP:0000148)2.34646709
40Gout (HP:0001997)2.33003820
41Atonic seizures (HP:0010819)2.31571147
42Shallow orbits (HP:0000586)2.31471212
43Aplasia/Hypoplasia of the tongue (HP:0010295)2.31050349
44Elevated circulating parathyroid hormone (PTH) level (HP:0003165)2.30386937
45Inability to walk (HP:0002540)2.29939737
46Postaxial foot polydactyly (HP:0001830)2.24613583
47Epileptiform EEG discharges (HP:0011182)2.24212857
48Abnormal drinking behavior (HP:0030082)2.22471271
49Polydipsia (HP:0001959)2.22471271
50Hypsarrhythmia (HP:0002521)2.21815797
51Absence seizures (HP:0002121)2.21251860
52EEG with generalized epileptiform discharges (HP:0011198)2.20453258
53Wrist flexion contracture (HP:0001239)2.18585150
54Anencephaly (HP:0002323)2.17493862
55Aplasia/Hypoplasia of the tibia (HP:0005772)2.16644986
56Skin nodule (HP:0200036)2.15098766
57Increased corneal curvature (HP:0100692)2.14004589
58Keratoconus (HP:0000563)2.14004589
59Ketoacidosis (HP:0001993)2.13755702
60Hypoplasia of the uterus (HP:0000013)2.13690885
61Aplasia/hypoplasia of the uterus (HP:0008684)2.13133145
62Dandy-Walker malformation (HP:0001305)2.12096671
63Abnormality of the labia minora (HP:0012880)2.10719624
64Hypoglycemic seizures (HP:0002173)2.10521221
65Bronchomalacia (HP:0002780)2.09333912
66Hyperventilation (HP:0002883)2.08971047
67Conjugated hyperbilirubinemia (HP:0002908)2.06797988
68Focal motor seizures (HP:0011153)2.06797319
69Anterior segment dysgenesis (HP:0007700)2.06222661
70Postaxial hand polydactyly (HP:0001162)2.05750094
71Patellar aplasia (HP:0006443)2.05481896
72Focal seizures (HP:0007359)2.03464672
73Chorioretinal atrophy (HP:0000533)2.03329658
74Abnormality of the lower motor neuron (HP:0002366)2.02585526
75Chronic hepatic failure (HP:0100626)2.01386489
76Aplasia/Hypoplasia of the pubic bone (HP:0009104)2.00778997
77Long toe (HP:0010511)1.99442960
78Poor coordination (HP:0002370)1.99310618
79Scrotal hypoplasia (HP:0000046)1.99041074
80Severe muscular hypotonia (HP:0006829)1.98871121
81Fair hair (HP:0002286)1.98668273
82Tubulointerstitial fibrosis (HP:0005576)1.97628290
83Deep venous thrombosis (HP:0002625)1.97030362
84Pachygyria (HP:0001302)1.97026011
85Preaxial hand polydactyly (HP:0001177)1.96615706
86Abnormal tarsal ossification (HP:0008369)1.96455868
87Aplasia/Hypoplasia of the sternum (HP:0006714)1.96445100
88Premature rupture of membranes (HP:0001788)1.96261632
89Resting tremor (HP:0002322)1.95101447
90Arterial tortuosity (HP:0005116)1.95091512
91Protuberant abdomen (HP:0001538)1.94120352
92Lymphangioma (HP:0100764)1.93459896
93Aplasia/Hypoplasia of the patella (HP:0006498)1.92775831
94Concave nail (HP:0001598)1.91828015
95Retinal dysplasia (HP:0007973)1.90777772
96Supernumerary spleens (HP:0009799)1.90346716
97Oligodactyly (hands) (HP:0001180)1.89919011
98Epileptic encephalopathy (HP:0200134)1.89808863
99Hypoplastic ischia (HP:0003175)1.89393016
100Vascular tortuosity (HP:0004948)1.88651889
101Tubulointerstitial abnormality (HP:0001969)1.87889052
102Congenital hepatic fibrosis (HP:0002612)1.87131530
103Agitation (HP:0000713)1.86598893
104Furrowed tongue (HP:0000221)1.86054016
105Bifid tongue (HP:0010297)1.85991202
106Metaphyseal cupping (HP:0003021)1.85550441
107Dialeptic seizures (HP:0011146)1.85484713
108Osteoarthritis (HP:0002758)1.85310752
109Neonatal short-limb short stature (HP:0008921)1.84399209
110Neurofibrillary tangles (HP:0002185)1.81362562
111Excessive salivation (HP:0003781)1.80766704
112Drooling (HP:0002307)1.80766704
113Short tibia (HP:0005736)1.80743390
114Abolished electroretinogram (ERG) (HP:0000550)1.80736997
115Abnormality of the pons (HP:0007361)1.79766701
116Mitral stenosis (HP:0001718)1.78320760
117Subacute progressive viral hepatitis (HP:0006572)1.78082743
118Large for gestational age (HP:0001520)1.78072789
119Polyuria (HP:0000103)1.77944068
120Abnormality of the ischium (HP:0003174)1.75638255
121Congenital, generalized hypertrichosis (HP:0004540)1.74845651
122Abnormality of aromatic amino acid family metabolism (HP:0004338)1.74050705
123Gaze-evoked nystagmus (HP:0000640)1.73894889
124Back pain (HP:0003418)1.73029257
125Methylmalonic aciduria (HP:0012120)1.72338075
126Hemiparesis (HP:0001269)1.72233022
127Hypoplasia of the odontoid process (HP:0003311)1.72006725
128Attenuation of retinal blood vessels (HP:0007843)1.71945827
129Partial agenesis of the corpus callosum (HP:0001338)1.71527653
130Broad foot (HP:0001769)1.71223391
131Symptomatic seizures (HP:0011145)1.71048165
132Exostoses (HP:0100777)1.71031103
133Thyroid-stimulating hormone excess (HP:0002925)1.70288151
134Pheochromocytoma (HP:0002666)1.68662283
135Renal hypoplasia (HP:0000089)1.68203865
136Torticollis (HP:0000473)1.67748507
137Specific learning disability (HP:0001328)1.67517034
138Broad-based gait (HP:0002136)1.66887257
139Abnormal respiratory motile cilium morphology (HP:0005938)1.66781471
140Abnormal respiratory epithelium morphology (HP:0012253)1.66781471
141Abnormal pancreas size (HP:0012094)1.66689564
142Broad metatarsal (HP:0001783)1.65718079
143Hypoplasia of the pons (HP:0012110)1.65220371
144Protruding tongue (HP:0010808)1.64716784
145Chorioretinal coloboma (HP:0000567)1.64615079
146Vitreoretinal degeneration (HP:0000655)1.63952558
147Progressive inability to walk (HP:0002505)1.63608751
148Adactyly (HP:0009776)1.63425821
149Depressed nasal tip (HP:0000437)1.63185693
150Bell-shaped thorax (HP:0001591)1.62151589
151Mucopolysacchariduria (HP:0008155)1.61866337
152Urinary glycosaminoglycan excretion (HP:0003541)1.61866337
153Congenital glaucoma (HP:0001087)1.61864893
154Astrocytoma (HP:0009592)1.61551840
155Abnormality of the astrocytes (HP:0100707)1.61551840
156Polymicrogyria (HP:0002126)1.61550475
157Atrophic scars (HP:0001075)1.60552198
158Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.60455964
159Labial hypoplasia (HP:0000066)1.60062650
160Narrow forehead (HP:0000341)1.59716648
161Microretrognathia (HP:0000308)1.59532493
162Anophthalmia (HP:0000528)1.58981380
163Neoplasm of the heart (HP:0100544)1.58772641
164Bladder diverticulum (HP:0000015)1.58703621
165Cerebral aneurysm (HP:0004944)1.58511422
166Overgrowth (HP:0001548)1.57816045
167Disproportionate short-trunk short stature (HP:0003521)1.57678708
168Abnormal rod and cone electroretinograms (HP:0008323)1.57421003
169Ketosis (HP:0001946)1.57342324
170Multicystic kidney dysplasia (HP:0000003)1.56639213
171Micropenis (HP:0000054)1.56036403
172Relative macrocephaly (HP:0004482)1.55865879
173Myokymia (HP:0002411)1.54157238
174Coronal craniosynostosis (HP:0004440)1.51933711
175Enlarged kidneys (HP:0000105)1.51219406
176Aneurysm (HP:0002617)1.50590076
177Mild short stature (HP:0003502)1.50062312
178Mitral valve prolapse (HP:0001634)1.48681625
179Hyperextensible skin (HP:0000974)1.48597919
180Hyperglycinemia (HP:0002154)1.48262344
181Hypoglycemic coma (HP:0001325)1.48255339
182Megalencephaly (HP:0001355)1.47840504
183Abnormality of the odontoid process (HP:0003310)1.47500149
184Abnormality of polysaccharide metabolism (HP:0011012)1.47444750
185Abnormality of glycosaminoglycan metabolism (HP:0004371)1.47444750
186Abnormality of mucopolysaccharide metabolism (HP:0011020)1.47444750
187Flat acetabular roof (HP:0003180)1.45319888
188Intrahepatic cholestasis (HP:0001406)1.45182675
189Buphthalmos (HP:0000557)1.43887327
190Insidious onset (HP:0003587)1.43556248
191Termporal pattern (HP:0011008)1.43556248
192Genu recurvatum (HP:0002816)1.43437293
193Exotropia (HP:0000577)1.43061674
194Ankle contracture (HP:0006466)1.43041940
195Osteopenia (HP:0000938)1.42883937
196Mixed hearing impairment (HP:0000410)1.42638331
197Insulin-resistant diabetes mellitus (HP:0000831)1.39961035

Predicted kinase interactions (KEA)

RankGene SetZ-score
1STK164.11341944
2MARK13.26009123
3PINK13.07036760
4BMPR1B2.81923237
5NTRK32.69526482
6INSRR2.60824604
7DDR22.50599348
8ZAK2.49057039
9PRKD32.46670907
10TRIB32.39752704
11EPHA42.33589960
12MAP4K22.25566168
13DAPK22.23775783
14ADRBK22.15325448
15ACVR1B2.13516122
16MAP3K92.02614500
17PDGFRA1.99281847
18NUAK11.95987533
19LATS21.94309249
20MAP3K21.93736672
21STK391.93410252
22NTRK11.86195948
23FER1.80609936
24PAK31.75554323
25CASK1.71205874
26LATS11.69702918
27MAP3K41.66788447
28PNCK1.66635115
29EPHA31.64345290
30KSR11.61472282
31PAK61.61137788
32GRK11.57822674
33FRK1.55812110
34TIE11.55112824
35TLK11.51875512
36AKT31.49443373
37OXSR11.42120990
38EPHA21.40371248
39PTK21.37707912
40ERBB31.34570177
41MINK11.32942202
42STK38L1.32043370
43DYRK21.31550851
44KSR21.28024673
45PKN21.24711206
46FGFR21.24584919
47SRPK11.24539967
48MKNK21.23783376
49FGFR41.22011114
50MET1.21346680
51RET1.20696870
52TYRO31.15639215
53MAP2K41.15388346
54EPHB21.13049807
55PLK21.12615624
56TNIK1.10679819
57PDK21.10385527
58ADRBK11.06615185
59NTRK21.06192850
60TGFBR11.04618449
61ERBB40.99951880
62SIK10.99771180
63WNK30.97763906
64FGFR10.97517076
65BCR0.97459967
66CSNK1G20.95182382
67SCYL20.91063831
68PIK3CA0.90687350
69CDK50.89466189
70CAMKK10.88488314
71SGK2230.88296910
72SGK4940.88296910
73TRIM280.87712450
74PTK60.86082005
75STK380.85599830
76WNK40.85050209
77TSSK60.84565298
78PRKCH0.83389367
79PLK30.83310267
80RIPK10.83037617
81PRKCG0.81984661
82PASK0.81979912
83CDC42BPA0.81582469
84NEK10.81314194
85BRSK20.80220671
86PRPF4B0.80052100
87MAPKAPK30.79586708
88MAP2K10.79408014
89CAMKK20.79177041
90DYRK1A0.78745241
91MKNK10.76508851
92PRKCI0.75799468
93ERN10.75429273
94PRKCE0.73935703
95UHMK10.73823405
96RPS6KA40.71147006
97PDGFRB0.70840874
98STK240.70617230
99SGK30.69541963
100WEE10.69516643
101TAOK30.68974001
102BCKDK0.68204063
103BUB10.68024192
104MAP2K70.67509966
105LMTK20.67395361
106EIF2AK10.67358748
107ALK0.67188093
108SGK20.66526884
109MTOR0.65490920
110STK30.65028983
111DAPK10.63367182
112MAPK150.62586662
113ERBB20.62161051
114FGFR30.62042887
115PRKCZ0.61844138
116TAOK10.60955261
117MAPK130.60732280
118CAMK2B0.60573288
119CSNK1A1L0.60301503
120MST1R0.59749342
121PHKG20.57824682
122PHKG10.57824682
123GSK3A0.57190787
124EPHB10.54766653
125RPS6KA50.53504461
126RAF10.53069440
127CAMK2A0.53026957
128RPS6KA20.52767207
129EIF2AK30.51843102
130DYRK1B0.50670394
131CHEK20.50298715
132CDK190.50053421
133PTK2B0.49649553
134MARK20.48184855
135PLK10.45957720
136CSNK1G10.45624909
137CSNK1A10.45616603
138CAMK10.44560228
139BMX0.44512956
140CDK180.43185614
141MAPK100.42707668
142CAMK1G0.42526914
143NEK20.42449843
144CSNK1G30.42312670
145SIK20.42286961
146NME10.41879686
147FLT30.41385031
148CDK140.40613241
149ILK0.40376396
150CDK150.39951163
151TTK0.39307897
152PRKCQ0.39023342
153LIMK10.38540524
154CSNK1D0.36843066
155ATM0.34136568

Predicted pathways (KEGG)

RankGene SetZ-score
1Caffeine metabolism_Homo sapiens_hsa002325.22221980
2Maturity onset diabetes of the young_Homo sapiens_hsa049503.11546278
3Phototransduction_Homo sapiens_hsa047442.65869968
4Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001302.46174597
5Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005632.33626617
6alpha-Linolenic acid metabolism_Homo sapiens_hsa005922.21986324
7Nitrogen metabolism_Homo sapiens_hsa009102.17290251
8Linoleic acid metabolism_Homo sapiens_hsa005912.00939854
9Synaptic vesicle cycle_Homo sapiens_hsa047211.92448730
10Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.92413036
11Insulin secretion_Homo sapiens_hsa049111.88400227
12Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.82520006
13Steroid biosynthesis_Homo sapiens_hsa001001.76164187
14Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.75572381
15Basal transcription factors_Homo sapiens_hsa030221.71867595
16Sulfur metabolism_Homo sapiens_hsa009201.70061192
17Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.68150802
18Vibrio cholerae infection_Homo sapiens_hsa051101.66416334
19Propanoate metabolism_Homo sapiens_hsa006401.59202589
20Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.58454935
21Butanoate metabolism_Homo sapiens_hsa006501.55327054
22Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.55002067
23RNA polymerase_Homo sapiens_hsa030201.52610674
24Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.48052430
25Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.47930067
26Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.47061280
27Cocaine addiction_Homo sapiens_hsa050301.44368062
28Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.42814291
29Amphetamine addiction_Homo sapiens_hsa050311.42308808
30Ether lipid metabolism_Homo sapiens_hsa005651.41849787
31Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.34570090
32Type II diabetes mellitus_Homo sapiens_hsa049301.30529787
33GABAergic synapse_Homo sapiens_hsa047271.30282733
34Vitamin digestion and absorption_Homo sapiens_hsa049771.26243817
35Nicotine addiction_Homo sapiens_hsa050331.24506046
36Fanconi anemia pathway_Homo sapiens_hsa034601.23805968
37Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.23673945
38Dopaminergic synapse_Homo sapiens_hsa047281.23557995
39RNA degradation_Homo sapiens_hsa030181.23063046
40Long-term potentiation_Homo sapiens_hsa047201.21734010
41Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.21062711
42Axon guidance_Homo sapiens_hsa043601.20535177
43Non-homologous end-joining_Homo sapiens_hsa034501.20140242
44Arginine biosynthesis_Homo sapiens_hsa002201.19287259
45Collecting duct acid secretion_Homo sapiens_hsa049661.17664026
46Circadian entrainment_Homo sapiens_hsa047131.16645190
47Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.14931530
48Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.10894775
49Bile secretion_Homo sapiens_hsa049761.09334938
50Aldosterone synthesis and secretion_Homo sapiens_hsa049251.08907757
51ABC transporters_Homo sapiens_hsa020101.06585821
52Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.05138874
53Glutamatergic synapse_Homo sapiens_hsa047241.04296519
54Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.03247689
55Homologous recombination_Homo sapiens_hsa034401.02300984
56Olfactory transduction_Homo sapiens_hsa047401.01663987
57Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.98846328
58Fatty acid biosynthesis_Homo sapiens_hsa000610.98526454
59Primary bile acid biosynthesis_Homo sapiens_hsa001200.98474795
60Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.97795094
61Protein digestion and absorption_Homo sapiens_hsa049740.97434778
62Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.95629597
63Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.94595716
64Thyroid hormone synthesis_Homo sapiens_hsa049180.94558388
65Tryptophan metabolism_Homo sapiens_hsa003800.90934085
66Cholinergic synapse_Homo sapiens_hsa047250.90897558
67Estrogen signaling pathway_Homo sapiens_hsa049150.90650195
68One carbon pool by folate_Homo sapiens_hsa006700.88946588
69Gap junction_Homo sapiens_hsa045400.88583345
70Hippo signaling pathway_Homo sapiens_hsa043900.87713475
71RNA transport_Homo sapiens_hsa030130.86501888
72mTOR signaling pathway_Homo sapiens_hsa041500.86396479
73Morphine addiction_Homo sapiens_hsa050320.85221422
742-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.85141729
75Peroxisome_Homo sapiens_hsa041460.84981212
76ECM-receptor interaction_Homo sapiens_hsa045120.84256589
77Endometrial cancer_Homo sapiens_hsa052130.81832980
78Protein export_Homo sapiens_hsa030600.81027066
79Chemical carcinogenesis_Homo sapiens_hsa052040.79670624
80Selenocompound metabolism_Homo sapiens_hsa004500.79571675
81Glioma_Homo sapiens_hsa052140.79286993
82Prion diseases_Homo sapiens_hsa050200.79094141
83Gastric acid secretion_Homo sapiens_hsa049710.78931514
84GnRH signaling pathway_Homo sapiens_hsa049120.78907607
85Renin secretion_Homo sapiens_hsa049240.78617646
86Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.78315509
87Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.78043733
88Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.77162085
89Glucagon signaling pathway_Homo sapiens_hsa049220.76828963
90Lysosome_Homo sapiens_hsa041420.76700282
91Melanogenesis_Homo sapiens_hsa049160.76600521
92Adherens junction_Homo sapiens_hsa045200.76542440
93Oxidative phosphorylation_Homo sapiens_hsa001900.76232258
94Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.75079818
95Cyanoamino acid metabolism_Homo sapiens_hsa004600.73797008
96Fat digestion and absorption_Homo sapiens_hsa049750.73788787
97Purine metabolism_Homo sapiens_hsa002300.73132749
98Focal adhesion_Homo sapiens_hsa045100.72272080
99Long-term depression_Homo sapiens_hsa047300.72153385
100Pancreatic secretion_Homo sapiens_hsa049720.71787987
101Carbohydrate digestion and absorption_Homo sapiens_hsa049730.70577885
102Nucleotide excision repair_Homo sapiens_hsa034200.70562257
103beta-Alanine metabolism_Homo sapiens_hsa004100.70169353
104TGF-beta signaling pathway_Homo sapiens_hsa043500.67457281
105Salivary secretion_Homo sapiens_hsa049700.67265409
106Metabolic pathways_Homo sapiens_hsa011000.67240014
107Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.67117927
108Bladder cancer_Homo sapiens_hsa052190.66987734
109Regulation of autophagy_Homo sapiens_hsa041400.65974039
110Fatty acid metabolism_Homo sapiens_hsa012120.65441785
111ErbB signaling pathway_Homo sapiens_hsa040120.65087919
112Sphingolipid metabolism_Homo sapiens_hsa006000.65000911
113Insulin resistance_Homo sapiens_hsa049310.64966283
114Fatty acid degradation_Homo sapiens_hsa000710.64938717
115Proteoglycans in cancer_Homo sapiens_hsa052050.64739897
116Taste transduction_Homo sapiens_hsa047420.64540797
117Hedgehog signaling pathway_Homo sapiens_hsa043400.64514418
118Dorso-ventral axis formation_Homo sapiens_hsa043200.64499292
119Glycerolipid metabolism_Homo sapiens_hsa005610.64102275
120Arachidonic acid metabolism_Homo sapiens_hsa005900.64042658
121Tight junction_Homo sapiens_hsa045300.63998318
122Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.62646677
123Insulin signaling pathway_Homo sapiens_hsa049100.62443535
124Cysteine and methionine metabolism_Homo sapiens_hsa002700.62102364
125Retinol metabolism_Homo sapiens_hsa008300.62001865
126Pyrimidine metabolism_Homo sapiens_hsa002400.61253393
127Oxytocin signaling pathway_Homo sapiens_hsa049210.60406365
128Proteasome_Homo sapiens_hsa030500.60404040
129Longevity regulating pathway - mammal_Homo sapiens_hsa042110.59450892
130Starch and sucrose metabolism_Homo sapiens_hsa005000.58775032
131N-Glycan biosynthesis_Homo sapiens_hsa005100.58357724
132cGMP-PKG signaling pathway_Homo sapiens_hsa040220.58066550
133Parkinsons disease_Homo sapiens_hsa050120.57803138
134Steroid hormone biosynthesis_Homo sapiens_hsa001400.57003114
135Phenylalanine metabolism_Homo sapiens_hsa003600.56413652
136Lysine degradation_Homo sapiens_hsa003100.56117619
137Phosphatidylinositol signaling system_Homo sapiens_hsa040700.55535898
138Circadian rhythm_Homo sapiens_hsa047100.55042875
139Arginine and proline metabolism_Homo sapiens_hsa003300.54894592
140Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.52766638
141Basal cell carcinoma_Homo sapiens_hsa052170.52440912
142Drug metabolism - other enzymes_Homo sapiens_hsa009830.52332725
143Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.52324512
144Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.51946387
145Wnt signaling pathway_Homo sapiens_hsa043100.51859913
146Dilated cardiomyopathy_Homo sapiens_hsa054140.51393774
147Renal cell carcinoma_Homo sapiens_hsa052110.51158846
148Huntingtons disease_Homo sapiens_hsa050160.50847802
149Serotonergic synapse_Homo sapiens_hsa047260.50719106
150AMPK signaling pathway_Homo sapiens_hsa041520.49085865
151Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.48840331
152PPAR signaling pathway_Homo sapiens_hsa033200.48237591
153Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.48114978
154Colorectal cancer_Homo sapiens_hsa052100.47617670
155Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.46634137
156Fatty acid elongation_Homo sapiens_hsa000620.46067194
157Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.44486387
158Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.43902341
159Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.43793115
160Ovarian steroidogenesis_Homo sapiens_hsa049130.43657652

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