SLC37A4

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene regulates glucose-6-phosphate transport from the cytoplasm to the lumen of the endoplasmic reticulum, in order to maintain glucose homeostasis. It also plays a role in ATP-mediated calcium sequestration in the lumen of the endoplasmic reticulum. Mutations in this gene have been associated with various forms of glycogen storage disease. Alternative splicing in this gene results in multiple transcript variants. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1L-phenylalanine catabolic process (GO:0006559)7.52741365
2erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)7.52741365
3L-phenylalanine metabolic process (GO:0006558)7.24000142
4erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)7.24000142
5aromatic amino acid family catabolic process (GO:0009074)6.71671821
6tryptophan catabolic process (GO:0006569)5.98639746
7indole-containing compound catabolic process (GO:0042436)5.98639746
8indolalkylamine catabolic process (GO:0046218)5.98639746
9glyoxylate metabolic process (GO:0046487)5.97239459
10triglyceride-rich lipoprotein particle remodeling (GO:0034370)5.77596975
11kynurenine metabolic process (GO:0070189)5.77476839
12tryptophan metabolic process (GO:0006568)5.68470602
13bile acid biosynthetic process (GO:0006699)5.56916881
14epoxygenase P450 pathway (GO:0019373)5.50539680
15cysteine metabolic process (GO:0006534)5.43789126
16lysine metabolic process (GO:0006553)5.27212498
17lysine catabolic process (GO:0006554)5.27212498
18urea cycle (GO:0000050)5.26495244
19urea metabolic process (GO:0019627)5.26495244
20sulfur amino acid catabolic process (GO:0000098)5.18691974
21alpha-linolenic acid metabolic process (GO:0036109)5.17262825
22serine family amino acid catabolic process (GO:0009071)5.06123857
23high-density lipoprotein particle remodeling (GO:0034375)5.05231436
24negative regulation of fibrinolysis (GO:0051918)5.00646871
25fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)4.96042360
26peptidyl-glutamic acid carboxylation (GO:0017187)4.93461303
27protein carboxylation (GO:0018214)4.93461303
28aromatic amino acid family metabolic process (GO:0009072)4.90769098
29nitrogen cycle metabolic process (GO:0071941)4.84931219
30homocysteine metabolic process (GO:0050667)4.82461067
31regulation of fibrinolysis (GO:0051917)4.80332436
32complement activation, alternative pathway (GO:0006957)4.76508390
33bile acid metabolic process (GO:0008206)4.75528256
34regulation of protein activation cascade (GO:2000257)4.72625010
35tyrosine metabolic process (GO:0006570)4.64716050
36amino-acid betaine metabolic process (GO:0006577)4.61965624
37alpha-amino acid catabolic process (GO:1901606)4.61961858
38cellular ketone body metabolic process (GO:0046950)4.56488645
39regulation of triglyceride catabolic process (GO:0010896)4.53980586
40NADH metabolic process (GO:0006734)4.47994236
41reverse cholesterol transport (GO:0043691)4.45860440
42regulation of cholesterol esterification (GO:0010872)4.42286374
43regulation of complement activation (GO:0030449)4.40412316
44acylglycerol homeostasis (GO:0055090)4.39197577
45triglyceride homeostasis (GO:0070328)4.39197577
46plasma lipoprotein particle remodeling (GO:0034369)4.34538472
47protein-lipid complex remodeling (GO:0034368)4.34538472
48macromolecular complex remodeling (GO:0034367)4.34538472
49drug catabolic process (GO:0042737)4.33523021
50cellular amino acid catabolic process (GO:0009063)4.31375067
51fructose metabolic process (GO:0006000)4.30995298
52indolalkylamine metabolic process (GO:0006586)4.30133470
53coenzyme catabolic process (GO:0009109)4.27437930
54drug transmembrane transport (GO:0006855)4.26735824
55negative regulation of cholesterol transport (GO:0032375)4.25653613
56negative regulation of sterol transport (GO:0032372)4.25653613
57omega-hydroxylase P450 pathway (GO:0097267)4.25114556
58cellular modified amino acid catabolic process (GO:0042219)4.24406051
59glutamate metabolic process (GO:0006536)4.23355594
60serine family amino acid metabolic process (GO:0009069)4.20453983
61phospholipid efflux (GO:0033700)4.18574699
62urate metabolic process (GO:0046415)4.16007991
63glycine metabolic process (GO:0006544)4.12521179
64amine catabolic process (GO:0009310)4.08358890
65cellular biogenic amine catabolic process (GO:0042402)4.08358890
66cellular glucuronidation (GO:0052695)4.04619601
67bile acid and bile salt transport (GO:0015721)4.02654178
68benzene-containing compound metabolic process (GO:0042537)4.02652344
69plasma lipoprotein particle clearance (GO:0034381)3.99233261
70proline metabolic process (GO:0006560)3.98947203
71very-low-density lipoprotein particle assembly (GO:0034379)3.98606392
72ketone body metabolic process (GO:1902224)3.95728162
73short-chain fatty acid metabolic process (GO:0046459)3.95274003
74aldehyde catabolic process (GO:0046185)3.92345597
75serine family amino acid biosynthetic process (GO:0009070)3.92287616
76aspartate family amino acid catabolic process (GO:0009068)3.90969771
77exogenous drug catabolic process (GO:0042738)3.88190087
78imidazole-containing compound metabolic process (GO:0052803)3.86363733
79dicarboxylic acid biosynthetic process (GO:0043650)3.86199607
80proline biosynthetic process (GO:0006561)3.85864720
81L-serine metabolic process (GO:0006563)3.84275342
82carboxylic acid catabolic process (GO:0046395)3.81769163
83organic acid catabolic process (GO:0016054)3.81769163
84acetyl-CoA metabolic process (GO:0006084)3.81394394
85cholesterol efflux (GO:0033344)3.79500639
86ethanol oxidation (GO:0006069)3.78170821
872-oxoglutarate metabolic process (GO:0006103)3.77949902
88arginine metabolic process (GO:0006525)3.76895899
89fat-soluble vitamin biosynthetic process (GO:0042362)3.73770071
90regulation of cholesterol homeostasis (GO:2000188)3.70963822
91uronic acid metabolic process (GO:0006063)3.66950100
92glucuronate metabolic process (GO:0019585)3.66950100
93plasma lipoprotein particle assembly (GO:0034377)3.65996223
94fatty acid beta-oxidation (GO:0006635)3.63386870
95fatty acid oxidation (GO:0019395)3.60830789
96regulation of bile acid biosynthetic process (GO:0070857)3.60361005
97cofactor catabolic process (GO:0051187)3.59617676
98positive regulation of triglyceride lipase activity (GO:0061365)3.59495246
99positive regulation of lipoprotein lipase activity (GO:0051006)3.59495246
100flavonoid metabolic process (GO:0009812)3.58141366
101monocarboxylic acid catabolic process (GO:0072329)3.57916538
102drug transport (GO:0015893)3.55753965
103phospholipid homeostasis (GO:0055091)3.55341136
104lipid oxidation (GO:0034440)3.53720283
105fibrinolysis (GO:0042730)3.53347222
106drug metabolic process (GO:0017144)3.52494348
107low-density lipoprotein particle remodeling (GO:0034374)3.49432170
108carnitine metabolic process (GO:0009437)3.49248859
109positive regulation of lipid catabolic process (GO:0050996)3.49090943
110oxaloacetate metabolic process (GO:0006107)3.39597991
111intestinal absorption (GO:0050892)3.36690424
112gluconeogenesis (GO:0006094)3.35310958
113L-alpha-amino acid transmembrane transport (GO:1902475)3.24051956
114hexose biosynthetic process (GO:0019319)3.23459300
115glutamine family amino acid biosynthetic process (GO:0009084)3.20490703
116protein-lipid complex assembly (GO:0065005)3.20322188
117monosaccharide biosynthetic process (GO:0046364)3.12323766
118phenylpropanoid metabolic process (GO:0009698)3.05637031
119intestinal cholesterol absorption (GO:0030299)3.00448252
1204-hydroxyproline metabolic process (GO:0019471)2.99041571
121ethanol metabolic process (GO:0006067)2.95383610
122vitamin biosynthetic process (GO:0009110)2.91037495
123regulation of systemic arterial blood pressure by renin-angiotensin (GO:0003081)2.90529969
124heme transport (GO:0015886)2.86848943
125angiotensin maturation (GO:0002003)2.86556228
126glucose 6-phosphate metabolic process (GO:0051156)2.85913274
127creatine metabolic process (GO:0006600)2.81105548
128ribosomal small subunit biogenesis (GO:0042274)2.76151450
129L-ascorbic acid metabolic process (GO:0019852)2.75992869
130DNA unwinding involved in DNA replication (GO:0006268)2.75835833
131plasma lipoprotein particle organization (GO:0071827)2.73545974
132blood coagulation, intrinsic pathway (GO:0007597)2.70015746
133regulation of cholesterol metabolic process (GO:0090181)2.66546748
134fatty acid catabolic process (GO:0009062)2.64898176
135glutamine family amino acid catabolic process (GO:0009065)2.63332452
136tetrahydrofolate metabolic process (GO:0046653)2.62430092
137DNA strand elongation involved in DNA replication (GO:0006271)2.61885617
138diacylglycerol metabolic process (GO:0046339)2.58557742
139protein-lipid complex subunit organization (GO:0071825)2.58049437
140glutamine family amino acid metabolic process (GO:0009064)2.57609345
141oxidative demethylation (GO:0070989)2.57026076
142telomere maintenance via semi-conservative replication (GO:0032201)2.55919872

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1* RXR_22158963_ChIP-Seq_LIVER_Mouse8.19371330
2PPARA_22158963_ChIP-Seq_LIVER_Mouse7.05759742
3EGR1_23403033_ChIP-Seq_LIVER_Mouse6.43914574
4LXR_22158963_ChIP-Seq_LIVER_Mouse6.30244742
5FOXO1_23066095_ChIP-Seq_LIVER_Mouse5.15494642
6PPARG_19300518_ChIP-PET_3T3-L1_Mouse5.02753496
7CEBPA_23403033_ChIP-Seq_LIVER_Mouse4.92322902
8E2F7_22180533_ChIP-Seq_HELA_Human4.13970599
9CEBPB_23403033_ChIP-Seq_LIVER_Mouse3.91683405
10NR1I2_20693526_ChIP-Seq_LIVER_Mouse3.90452629
11MYC_18555785_ChIP-Seq_MESCs_Mouse3.04463654
12EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.99661979
13HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.86070193
14KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.56275022
15FOXM1_23109430_ChIP-Seq_U2OS_Human2.51668435
16MYC_18358816_ChIP-ChIP_MESCs_Mouse2.41260901
17TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse2.30233935
18JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.29482931
19XRN2_22483619_ChIP-Seq_HELA_Human2.20448647
20HNF4A_19761587_ChIP-ChIP_CACO-2_Human2.20149489
21FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.19940964
22TCF7L2_21901280_ChIP-Seq_H4IIE_Rat2.10921202
23AR_21909140_ChIP-Seq_LNCAP_Human2.05742263
24MYC_19030024_ChIP-ChIP_MESCs_Mouse2.03066540
25MYC_19079543_ChIP-ChIP_MESCs_Mouse2.02796914
26ESR1_17901129_ChIP-ChIP_LIVER_Mouse11.5942345
27THAP11_20581084_ChIP-Seq_MESCs_Mouse1.90757149
28E2F1_18555785_ChIP-Seq_MESCs_Mouse1.80768350
29ETS1_20019798_ChIP-Seq_JURKAT_Human1.78887025
30MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.76266705
31DCP1A_22483619_ChIP-Seq_HELA_Human1.73870929
32CREB1_15753290_ChIP-ChIP_HEK293T_Human1.72581490
33NELFA_20434984_ChIP-Seq_ESCs_Mouse1.72240190
34GATA1_22025678_ChIP-Seq_K562_Human1.71163210
35ZFX_18555785_ChIP-Seq_MESCs_Mouse1.70931075
36CLOCK_20551151_ChIP-Seq_293T_Human1.68642257
37NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.68262675
38POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.62797966
39FOXA2_19822575_ChIP-Seq_HepG2_Human1.60364577
40CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.56691566
41TTF2_22483619_ChIP-Seq_HELA_Human1.55872457
42ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.54458690
43* GABP_19822575_ChIP-Seq_HepG2_Human1.52332201
44HNF4A_19822575_ChIP-Seq_HepG2_Human1.43839711
45NANOG_18555785_ChIP-Seq_MESCs_Mouse1.43457232
46SRF_21415370_ChIP-Seq_HL-1_Mouse1.42628491
47E2F4_17652178_ChIP-ChIP_JURKAT_Human1.38851973
48POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.37518672
49EST1_17652178_ChIP-ChIP_JURKAT_Human1.36300440
50KDM5A_27292631_Chip-Seq_BREAST_Human1.35499310
51MYCN_18555785_ChIP-Seq_MESCs_Mouse1.34825921
52HTT_18923047_ChIP-ChIP_STHdh_Human1.34595535
53CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.32412104
54SRY_22984422_ChIP-ChIP_TESTIS_Rat1.30087148
55GABP_17652178_ChIP-ChIP_JURKAT_Human1.28294308
56DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.28036662
57ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.26977967
58STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.26946149
59KLF4_18555785_ChIP-Seq_MESCs_Mouse1.25078097
60PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.24315753
61E2F1_21310950_ChIP-Seq_MCF-7_Human1.24118800
62FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.22132362
63THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.20968186
64ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.15187815
65KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.14021346
66YY1_21170310_ChIP-Seq_MESCs_Mouse1.13592825
67* TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.13549273
68TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.13447058
69OCT4_18692474_ChIP-Seq_MEFs_Mouse1.12827854
70RXRA_24833708_ChIP-Seq_LIVER_Mouse1.12670160
71PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.11598260
72* SOX2_27498859_Chip-Seq_STOMACH_Mouse1.10138108
73NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.09954536
74BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.09230368
75* FOXP1_21924763_ChIP-Seq_HESCs_Human1.08363444
76CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.07991562
77MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.07498048
78P68_20966046_ChIP-Seq_HELA_Human1.05989540
79* CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.05822178
80ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.05552732
81POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.05238611
82CTCF_18555785_ChIP-Seq_MESCs_Mouse1.05154459
83STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.02889172
84FOXP3_21729870_ChIP-Seq_TREG_Human0.99114040
85TBX5_21415370_ChIP-Seq_HL-1_Mouse0.98333407
86CNOT3_19339689_ChIP-ChIP_MESCs_Mouse0.98216390
87* SOX2_18692474_ChIP-Seq_MEFs_Mouse0.97579682
88KLF4_19030024_ChIP-ChIP_MESCs_Mouse0.97426618
89E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human0.97375423
90DMRT1_21621532_ChIP-ChIP_FETAL_Ovary0.95868342
91HIF1A_21447827_ChIP-Seq_MCF-7_Human0.95467067
92IRF1_21803131_ChIP-Seq_MONOCYTES_Human0.94031605
93CHD1_26751641_Chip-Seq_LNCaP_Human0.93980287
94* CTCF_27219007_Chip-Seq_Bcells_Human0.93923288
95SOX9_22984422_ChIP-ChIP_TESTIS_Rat0.93452309
96PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse0.92989215
97CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human0.92685754
98RARG_19884340_ChIP-ChIP_MEFs_Mouse0.92096529
99GATA4_25053715_ChIP-Seq_YYC3_Human0.91132979
100IRF8_22096565_ChIP-ChIP_GC-B_Human0.90227811
101ZNF652_21678463_ChIP-ChIP_ZR75-1_Human0.89287008
102SREBP1_19666523_ChIP-Seq_LIVER_Mouse0.87433267
103BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.83953169
104SREBP2_21459322_ChIP-Seq_LIVER_Mouse0.81399475
105AR_21915096_ChIP-Seq_LNCaP-1F5_Human0.79044320
106RARA_24833708_ChIP-Seq_LIVER_Mouse0.77147044
107* LXR_22292898_ChIP-Seq_THP-1_Human0.76575415
108* AUTS2_25519132_ChIP-Seq_293T-REX_Human0.72368779
109ESR1_21235772_ChIP-Seq_MCF-7_Human0.72090852
110NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human0.71673149
111NR0B1_18358816_ChIP-ChIP_MESCs_Mouse0.69802564
112* PDX1_19855005_ChIP-ChIP_MIN6_Mouse0.68711847
113ESR2_21235772_ChIP-Seq_MCF-7_Human0.68619092
114ESR1_15608294_ChIP-ChIP_MCF-7_Human0.66827583
115RARB_24833708_ChIP-Seq_LIVER_Mouse0.65777592
116BMI1_19503595_ChIP-Seq_MEFsC_Mouse0.65130794
117RAD21_21589869_ChIP-Seq_MESCs_Mouse0.64383529
118AR_20517297_ChIP-Seq_VCAP_Human0.64006712
119KAP1_22055183_ChIP-Seq_ESCs_Mouse0.63475030
120PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse0.62451017
121ZNF263_19887448_ChIP-Seq_K562_Human0.62113973
122TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse0.61791778
123FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human0.61017081
124CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.60232951
125RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human0.59736324
126Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse0.59663283
127NFE2L2_20460467_ChIP-Seq_MEFs_Mouse0.58834111
128NRF2_20460467_ChIP-Seq_MEFs_Mouse0.58834111
129E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse0.57737379
130FOXA1_25552417_ChIP-Seq_VCAP_Human0.57371341
131PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.57262788
132GATA1_19941826_ChIP-Seq_K562_Human0.57231566
133SALL4_18804426_ChIP-ChIP_XEN_Mouse0.56600538
134SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.56553200
135CEBPB_22108803_ChIP-Seq_LS180_Human0.56540761
136SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.56419377
137MYC_19915707_ChIP-ChIP_AK7_Human0.56359636
138EGR1_19032775_ChIP-ChIP_M12_Human0.56038659
139GATA1_19941827_ChIP-Seq_MEL_Mouse0.54892785
140FOXA1_26743006_Chip-Seq_LNCaP-abl_Human0.52875469
141STAT3_1855785_ChIP-Seq_MESCs_Mouse0.52781080
142TAF2_19829295_ChIP-Seq_ESCs_Human0.52542195
143PBX1_22567123_ChIP-ChIP_OVCAR3_Human0.51485333
144CBP_21632823_ChIP-Seq_H3396_Human0.51223883
145GATA6_25053715_ChIP-Seq_YYC3_Human0.50831881
146P53_21459846_ChIP-Seq_SAOS-2_Human0.49556642
147GATA2_19941826_ChIP-Seq_K562_Human0.48657465
148ESET_19884257_ChIP-Seq_ESCs_Mouse0.47155638
149PPARD_23208498_ChIP-Seq_MDA-MB-231_Human0.46611626
150CDX2_20551321_ChIP-Seq_CACO-2_Human0.46415969
151GATA2_20887958_ChIP-Seq_HPC-7_Mouse0.46352601
152ERG_20517297_ChIP-Seq_VCAP_Human0.46072651
153OCT4_20526341_ChIP-Seq_ESCs_Human0.44547345
154STAT1_17558387_ChIP-Seq_HELA_Human0.43943249
155EBNA1_20929547_Chip-Seq_RAJI-cells_Human0.43919517
156TET1_21451524_ChIP-Seq_MESCs_Mouse0.43812522
157EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human0.43196584
158GATA3_20176728_ChIP-ChIP_TSCs_Mouse0.42477595
159BCOR_27268052_Chip-Seq_Bcells_Human0.42466113
160SMAD2/3_21741376_ChIP-Seq_ESCs_Human0.41831021
161FOXO3_23340844_ChIP-Seq_DLD1_Human0.41817269
162PPARG_20887899_ChIP-Seq_3T3-L1_Mouse0.41741057
163ERG_21242973_ChIP-ChIP_JURKAT_Human0.41241742
164FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human0.40843535
165P63_20808887_ChIP-Seq_KERATINOCYTES_Human0.40576893
166RACK7_27058665_Chip-Seq_MCF-7_Human0.40097692
167GATA3_24758297_ChIP-Seq_MCF-7_Human0.39981539
168ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.39751002
169RAC3_21632823_ChIP-Seq_H3396_Human0.39377703

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002139_abnormal_hepatobiliary_system8.09122674
2MP0005360_urolithiasis7.68859332
3MP0005085_abnormal_gallbladder_physiolo5.98380089
4MP0005365_abnormal_bile_salt5.85492914
5MP0008875_abnormal_xenobiotic_pharmacok4.94310875
6MP0003806_abnormal_nucleotide_metabolis4.01207853
7MP0003252_abnormal_bile_duct3.80676927
8MP0010329_abnormal_lipoprotein_level3.38410600
9MP0003195_calcinosis3.34511428
10MP0005332_abnormal_amino_acid3.14021415
11MP0009840_abnormal_foam_cell3.09152084
12MP0003693_abnormal_embryo_hatching2.79293212
13MP0005083_abnormal_biliary_tract2.73825401
14MP0000566_synostosis2.70021183
15MP0001666_abnormal_nutrient_absorption2.59990445
16MP0004019_abnormal_vitamin_homeostasis2.51750199
17MP0002138_abnormal_hepatobiliary_system2.30130605
18MP0003191_abnormal_cellular_cholesterol2.27239793
19MP0010234_abnormal_vibrissa_follicle2.16389031
20* MP0002118_abnormal_lipid_homeostasis2.07591244
21MP0000609_abnormal_liver_physiology2.07356776
22MP0004957_abnormal_blastocyst_morpholog1.90590363
23MP0005319_abnormal_enzyme/_coenzyme1.86793842
24MP0003868_abnormal_feces_composition1.86314745
25MP0003123_paternal_imprinting1.84307449
26MP0003111_abnormal_nucleus_morphology1.81764924
27MP0009643_abnormal_urine_homeostasis1.75438716
28MP0010030_abnormal_orbit_morphology1.70086214
29MP0009379_abnormal_foot_pigmentation1.69887618
30MP0005584_abnormal_enzyme/coenzyme_acti1.66397600
31* MP0001764_abnormal_homeostasis1.56114935
32MP0003283_abnormal_digestive_organ1.51757865
33MP0005451_abnormal_body_composition1.45916431
34MP0010094_abnormal_chromosome_stability1.41074822
35MP0005636_abnormal_mineral_homeostasis1.37503946
36MP0004043_abnormal_pH_regulation1.36221030
37MP0003718_maternal_effect1.32870110
38MP0005377_hearing/vestibular/ear_phenot1.30467131
39MP0003878_abnormal_ear_physiology1.30467131
40MP0003186_abnormal_redox_activity1.30291570
41MP0009697_abnormal_copulation1.29334450
42MP0000678_abnormal_parathyroid_gland1.24281512
43MP0008932_abnormal_embryonic_tissue1.20714520
44MP0003656_abnormal_erythrocyte_physiolo1.20158549
45MP0006292_abnormal_olfactory_placode1.17060817
46MP0006036_abnormal_mitochondrial_physio1.15561545
47MP0001730_embryonic_growth_arrest1.12798961
48* MP0000598_abnormal_liver_morphology1.12561278
49MP0002938_white_spotting1.09831468
50MP0002249_abnormal_larynx_morphology1.08597102
51MP0003011_delayed_dark_adaptation1.06828977
52MP0003077_abnormal_cell_cycle1.05144879
53MP0003315_abnormal_perineum_morphology1.03817532
54* MP0002078_abnormal_glucose_homeostasis1.02783511
55MP0001756_abnormal_urination1.02050641
56MP0000537_abnormal_urethra_morphology1.01942312
57MP0000604_amyloidosis1.00396106
58MP0005670_abnormal_white_adipose0.99497166
59MP0005220_abnormal_exocrine_pancreas0.96514440
60* MP0009642_abnormal_blood_homeostasis0.95167185
61MP0003879_abnormal_hair_cell0.94957441
62MP0002909_abnormal_adrenal_gland0.93039494
63MP0005379_endocrine/exocrine_gland_phen0.92412709
64MP0009764_decreased_sensitivity_to0.91850163
65MP0002876_abnormal_thyroid_physiology0.90396487
66MP0005084_abnormal_gallbladder_morpholo0.89727706
67MP0005647_abnormal_sex_gland0.89664618
68MP0002697_abnormal_eye_size0.89548763
69MP0009763_increased_sensitivity_to0.89211849
70MP0003705_abnormal_hypodermis_morpholog0.88232153
71MP0008469_abnormal_protein_level0.88203040
72MP0005535_abnormal_body_temperature0.86941165
73MP0002837_dystrophic_cardiac_calcinosis0.86287058
74MP0000462_abnormal_digestive_system0.85351253
75MP0001293_anophthalmia0.84962172
76MP0005408_hypopigmentation0.84242125
77MP0004130_abnormal_muscle_cell0.84194084
78MP0002971_abnormal_brown_adipose0.81548276
79MP0003122_maternal_imprinting0.80507054
80MP0002089_abnormal_postnatal_growth/wei0.80391424
81MP0001765_abnormal_ion_homeostasis0.79018760
82MP0004858_abnormal_nervous_system0.78227926
83MP0000477_abnormal_intestine_morphology0.77896099
84MP0002163_abnormal_gland_morphology0.77668886
85MP0000490_abnormal_crypts_of0.77199810
86MP0008058_abnormal_DNA_repair0.76836842
87MP0002136_abnormal_kidney_physiology0.76780151
88MP0001661_extended_life_span0.75361634
89MP0005334_abnormal_fat_pad0.74845645
90MP0001346_abnormal_lacrimal_gland0.73780190
91* MP0005376_homeostasis/metabolism_phenot0.72332730
92MP0003938_abnormal_ear_development0.70750271
93MP0004233_abnormal_muscle_weight0.70683838
94MP0010368_abnormal_lymphatic_system0.70305547
95MP0005058_abnormal_lysosome_morphology0.69685400
96MP0001529_abnormal_vocalization0.69586721
97MP0009765_abnormal_xenobiotic_induced0.69485912
98MP0005330_cardiomyopathy0.68955497
99MP0003329_amyloid_beta_deposits0.67213281
100MP0005380_embryogenesis_phenotype0.66360748
101MP0001672_abnormal_embryogenesis/_devel0.66360748
102MP0005266_abnormal_metabolism0.65714193
103MP0000003_abnormal_adipose_tissue0.65423898
104MP0001697_abnormal_embryo_size0.64918246
105MP0002254_reproductive_system_inflammat0.63743827
106MP0002928_abnormal_bile_duct0.63064747
107MP0006035_abnormal_mitochondrial_morpho0.61706571
108MP0003119_abnormal_digestive_system0.60567035
109MP0010352_gastrointestinal_tract_polyps0.60125106
110MP0005501_abnormal_skin_physiology0.59794142
111MP0004133_heterotaxia0.59633005
112MP0003984_embryonic_growth_retardation0.59371126
113MP0005448_abnormal_energy_balance0.58825488
114MP0002080_prenatal_lethality0.58590885
115MP0005666_abnormal_adipose_tissue0.57957671
116MP0002085_abnormal_embryonic_tissue0.57796662
117MP0002796_impaired_skin_barrier0.57631125
118MP0003953_abnormal_hormone_level0.57469678
119MP0000230_abnormal_systemic_arterial0.56958100
120MP0003183_abnormal_peptide_metabolism0.56366170
121MP0000639_abnormal_adrenal_gland0.55543282
122MP0001944_abnormal_pancreas_morphology0.54491250
123MP0003638_abnormal_response/metabolism_0.50465550
124MP0003690_abnormal_glial_cell0.49242204
125MP0003300_gastrointestinal_ulcer0.45381776
126MP0004264_abnormal_extraembryonic_tissu0.44519879
127MP0000538_abnormal_urinary_bladder0.43986914
128MP0005464_abnormal_platelet_physiology0.43822932
129MP0005395_other_phenotype0.43177847
130MP0009672_abnormal_birth_weight0.42955898
131MP0002168_other_aberrant_phenotype0.41247782
132MP0002822_catalepsy0.41157776
133MP0008874_decreased_physiological_sensi0.38528370
134MP0009053_abnormal_anal_canal0.38410081
135MP0002269_muscular_atrophy0.38091632
136MP0008873_increased_physiological_sensi0.37378925
137MP0008961_abnormal_basal_metabolism0.37185875
138MP0002693_abnormal_pancreas_physiology0.36894727
139MP0003959_abnormal_lean_body0.36794316
140MP0004782_abnormal_surfactant_physiolog0.35784580
141MP0002970_abnormal_white_adipose0.35166470
142MP0003075_altered_response_to0.34993427
143MP0005166_decreased_susceptibility_to0.33991569
144MP0003724_increased_susceptibility_to0.32650260
145MP0003436_decreased_susceptibility_to0.30973445
146* MP0002135_abnormal_kidney_morphology0.30865410
147MP0009115_abnormal_fat_cell0.30236420
148MP0008872_abnormal_physiological_respon0.29149290
149* MP0001845_abnormal_inflammatory_respons0.28952968
150MP0009780_abnormal_chondrocyte_physiolo0.28703345
151MP0004147_increased_porphyrin_level0.28617446
152MP0000249_abnormal_blood_vessel0.26127353
153MP0005375_adipose_tissue_phenotype0.26111422

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of aromatic amino acid family metabolism (HP:0004338)7.19716523
2Intrahepatic cholestasis (HP:0001406)6.50822617
3Deep venous thrombosis (HP:0002625)6.35850058
4Abnormality of monocarboxylic acid metabolism (HP:0010996)6.08690544
5Hypobetalipoproteinemia (HP:0003563)5.65540976
6Prolonged partial thromboplastin time (HP:0003645)5.63319570
7* Xanthomatosis (HP:0000991)5.53178397
8Hyperlipoproteinemia (HP:0010980)4.91304182
9Complement deficiency (HP:0004431)4.57577010
10Hyperammonemia (HP:0001987)4.57210591
11* Ketosis (HP:0001946)4.56720381
12Abnormality of glutamine family amino acid metabolism (HP:0010902)4.51501906
13Hypoglycemic coma (HP:0001325)4.45927189
14Hyperglycinemia (HP:0002154)4.31672842
15Hyperglycinuria (HP:0003108)4.31622906
16Hypolipoproteinemia (HP:0010981)4.27361638
17Joint hemorrhage (HP:0005261)4.25465589
18Abnormality of serine family amino acid metabolism (HP:0010894)4.13493698
19Abnormality of glycine metabolism (HP:0010895)4.13493698
20Abnormality of aspartate family amino acid metabolism (HP:0010899)4.10230161
21Abnormality of sulfur amino acid metabolism (HP:0004339)4.06933727
22Abnormality of the common coagulation pathway (HP:0010990)4.06808535
23Epidermoid cyst (HP:0200040)3.93751809
24Ketoacidosis (HP:0001993)3.92088620
25Abnormality of the level of lipoprotein cholesterol (HP:0010979)3.88716213
26Abnormality of methionine metabolism (HP:0010901)3.81141650
27Hypoalphalipoproteinemia (HP:0003233)3.76017748
28Fat malabsorption (HP:0002630)3.73895253
29Abnormality of fatty-acid metabolism (HP:0004359)3.66167367
30Abnormality of the intrinsic pathway (HP:0010989)3.59419695
31Conjugated hyperbilirubinemia (HP:0002908)3.47570452
32Abnormality of pyrimidine metabolism (HP:0004353)3.45155203
33Abnormality of long-chain fatty-acid metabolism (HP:0010964)3.44346510
34Abnormality of complement system (HP:0005339)3.25901052
35Hyperbilirubinemia (HP:0002904)3.23869205
36* Abnormality of nucleobase metabolism (HP:0010932)3.22584028
37* Abnormality of purine metabolism (HP:0004352)3.10761031
38Generalized aminoaciduria (HP:0002909)3.09849735
39Hypoglycemic seizures (HP:0002173)3.08369257
40Hypercholesterolemia (HP:0003124)3.05667376
41Delayed CNS myelination (HP:0002188)3.05656529
42Abnormality of serum amino acid levels (HP:0003112)2.98917433
43Reticulocytopenia (HP:0001896)2.98384080
44* Metabolic acidosis (HP:0001942)2.92489834
45Abnormality of dicarboxylic acid metabolism (HP:0010995)2.89314438
46Dicarboxylic aciduria (HP:0003215)2.89314438
47Late onset (HP:0003584)2.81044281
48Lethargy (HP:0001254)2.79533454
49Hyperinsulinemic hypoglycemia (HP:0000825)2.76265994
50Megaloblastic anemia (HP:0001889)2.73880423
51* Gout (HP:0001997)2.72482327
52Steatorrhea (HP:0002570)2.71669450
53Abnormality of vitamin metabolism (HP:0100508)2.61069125
54Hyperphosphaturia (HP:0003109)2.60858153
55Cerebral edema (HP:0002181)2.60223997
56Irritability (HP:0000737)2.58868503
57Vascular calcification (HP:0004934)2.56423482
58Proximal tubulopathy (HP:0000114)2.56201479
59Alkalosis (HP:0001948)2.56061018
60Abnormality of glycolysis (HP:0004366)2.54791672
61Skin nodule (HP:0200036)2.54306879
62Aplasia/Hypoplasia of the sacrum (HP:0008517)2.50247613
63Myopathic facies (HP:0002058)2.49380502
64Abnormality of the pancreatic islet cells (HP:0006476)2.48617968
65Reduced antithrombin III activity (HP:0001976)2.48454566
66Macrocytic anemia (HP:0001972)2.46398568
67Spontaneous abortion (HP:0005268)2.45937603
68Systemic lupus erythematosus (HP:0002725)2.44367903
69Neonatal onset (HP:0003623)2.44062475
70Abnormal gallbladder morphology (HP:0012437)2.41050398
71* Hepatocellular carcinoma (HP:0001402)2.40671154
72Malnutrition (HP:0004395)2.37972619
73Vomiting (HP:0002013)2.37595985
74Myocardial infarction (HP:0001658)2.36938654
75Abnormality of urine glucose concentration (HP:0011016)2.36161486
76Glycosuria (HP:0003076)2.36161486
77Abnormal urine phosphate concentration (HP:0012599)2.35571284
78Spastic diplegia (HP:0001264)2.35155644
79Symptomatic seizures (HP:0011145)2.33079875
80Cholelithiasis (HP:0001081)2.32105481
81Cholecystitis (HP:0001082)2.31814704
82Abnormal gallbladder physiology (HP:0012438)2.31814704
83Hypochromic microcytic anemia (HP:0004840)2.30565252
84Increased serum pyruvate (HP:0003542)2.30552161
85Rhabdomyolysis (HP:0003201)2.28526905
86Acute encephalopathy (HP:0006846)2.25240695
87Cardiovascular calcification (HP:0011915)2.23927171
88Vaginal fistula (HP:0004320)2.22856060
89Pancreatic islet-cell hyperplasia (HP:0004510)2.22385401
90Sensorimotor neuropathy (HP:0007141)2.22212891
91Hydroxyprolinuria (HP:0003080)2.20526482
92Abnormality of proline metabolism (HP:0010907)2.20526482
93Abnormality of vitamin B metabolism (HP:0004340)2.19975248
94Acanthocytosis (HP:0001927)2.17376291
95Chromosomal breakage induced by crosslinking agents (HP:0003221)2.16965420
96Mitral stenosis (HP:0001718)2.14690844
97Rickets (HP:0002748)2.11526944
98Abnormal enzyme/coenzyme activity (HP:0012379)2.11039599
99Abnormality of reticulocytes (HP:0004312)2.10624712
100Brushfield spots (HP:0001088)2.09721848
101Hyperglycemia (HP:0003074)2.09720953
102Glomerulonephritis (HP:0000099)2.07594288
103Chromsome breakage (HP:0040012)2.06156310
104* Increased purine levels (HP:0004368)2.04367008
105* Hyperuricemia (HP:0002149)2.04367008
106* Pancreatitis (HP:0001733)2.01870367
107Osteomalacia (HP:0002749)2.01278542
108Abnormality of the vitamin B12 metabolism (HP:0004341)2.01210126
109Opisthotonus (HP:0002179)1.99027569
110Abnormality of the gallbladder (HP:0005264)1.98838103
111Hepatic necrosis (HP:0002605)1.97935150
112Recurrent gram-negative bacterial infections (HP:0005420)1.94685057
113Myoglobinuria (HP:0002913)1.93704688
114Ileus (HP:0002595)1.93404487
115Bifid scrotum (HP:0000048)1.93269384
116Exercise-induced myalgia (HP:0003738)1.92594204
117Menorrhagia (HP:0000132)1.92126928
118Amyloidosis (HP:0011034)1.91622271
119Abnormality of alkaline phosphatase activity (HP:0004379)1.89877490
120Elevated alkaline phosphatase (HP:0003155)1.88753064
121Esophageal varix (HP:0002040)1.88195176
122Abnormal mitochondria in muscle tissue (HP:0008316)1.87815992
123Nausea (HP:0002018)1.85977058
124Renal cortical cysts (HP:0000803)1.85364409
125Thrombophlebitis (HP:0004418)1.84755255
126Acute hepatic failure (HP:0006554)1.84036656
127Cerebral palsy (HP:0100021)1.80902008
128Hypophosphatemic rickets (HP:0004912)1.79781742
129Hemorrhage of the eye (HP:0011885)1.79761567
130Abnormality of endocrine pancreas physiology (HP:0012093)1.79577256
131Acute necrotizing encephalopathy (HP:0006965)1.78984273
132Abnormality of the Achilles tendon (HP:0005109)1.78338449
133Exercise-induced muscle cramps (HP:0003710)1.77949857
134Microvesicular hepatic steatosis (HP:0001414)1.72344378

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BCKDK7.17805486
2ERN14.23948109
3FGFR44.10030772
4INSRR4.06627219
5SIK13.71992120
6BUB13.52939377
7VRK22.94187009
8TAOK32.80131063
9NME22.77205888
10EPHA22.69761311
11TTK2.51352571
12ACVR1B2.48288040
13TRIB32.46001455
14NME12.43211200
15CDC72.41476584
16PKN22.25257264
17WNK42.25170603
18ERBB42.17624082
19FLT32.14448016
20SMG12.13650529
21PBK2.04573279
22WNK32.00395449
23MAP2K41.93761445
24MST1R1.90827265
25PIK3CG1.82508097
26EIF2AK11.82029423
27ICK1.78015850
28MAPK111.77964739
29STK161.71825065
30EEF2K1.67956591
31SRPK11.62357129
32TESK21.61839568
33MAPK151.59915890
34PTK61.44405330
35BRSK11.44227702
36WEE11.37938587
37OXSR11.35733363
38PINK11.34796858
39FRK1.34257828
40PLK11.28880149
41TYK21.23714171
42MAP2K31.21717850
43ARAF1.21291998
44NEK91.20990972
45BRAF1.18932108
46MAP3K71.18853613
47JAK21.18236833
48BRSK21.16513783
49AURKB1.12433691
50DAPK21.12067358
51CDK71.09817378
52VRK11.09166612
53PRKAA21.08686779
54GRK61.08653371
55ABL21.08367188
56EPHA31.06283719
57KDR1.05535847
58EPHB11.04326185
59SCYL20.96978215
60MAP3K80.96769999
61PAK40.96616173
62MAP3K30.95976923
63NEK20.95927529
64PDK30.95379777
65PDK40.95379777
66STK38L0.93552077
67PLK30.92190306
68AKT20.91440860
69MAP3K100.90198395
70CHEK20.87738069
71STK40.87252746
72LATS10.87180030
73AURKA0.86605070
74DYRK1B0.86204250
75RIPK10.85668771
76IRAK30.85494359
77JAK10.84620471
78PRKG20.84618707
79MET0.82354384
80PTK20.82215273
81ATR0.81993003
82OBSCN0.80668290
83TBK10.80368502
84CDK40.80015045
85CDK80.79476842
86CHEK10.79115137
87PRKAA10.78871585
88MAP2K60.77067489
89TAOK10.75949641
90MAP3K20.75892786
91PRKCI0.74756548
92MAPK40.74559765
93PLK40.74126507
94RPS6KB20.74077765
95PRKCZ0.73691554
96PRKACG0.73277433
97SGK30.71383926
98GSK3A0.71210271
99TESK10.70107541
100TIE10.70001361
101SGK4940.69911082
102SGK2230.69911082
103LMTK20.67857399
104CSNK2A10.67676038
105BMX0.67296059
106NEK10.66908050
107MAPK120.66884512
108CSNK2A20.66654601
109ERBB20.64463038
110PDPK10.64408020
111ZAK0.64025001
112IRAK10.62622707
113MAP3K110.61980108
114PIM20.61352491
115FGFR20.60915537
116SGK20.57887385
117CAMK2G0.56175319
118CSK0.55699763
119CDK20.51860562
120CDK10.51544088
121RET0.50472971
122TGFBR20.49494073
123KSR20.48936276
124MAP3K140.48661999
125MAP3K10.48058646
126MST40.48030326
127ATM0.46633610
128LRRK20.46381281
129PDK10.44688559
130FGFR10.44477104
131CAMK2D0.44393253
132CCNB10.41465369
133PRKCQ0.40628387
134MAP2K10.40530251
135EPHA40.38825151
136CSNK1A10.38779298
137CSNK1E0.38775934
138FGFR30.37158566
139MAP3K50.37147582
140TLK10.36956575
141PAK10.36800385
142HIPK20.35843262
143MAP2K20.34543181
144IGF1R0.34182144
145PAK30.33659491
146IRAK20.32841040
147CAMK1D0.32708926
148PRKCG0.32604255
149DYRK20.31259776
150PDK20.30673968
151MAPK70.29741852
152CSNK1G10.27693410
153PRKCA0.26579589
154ITK0.26168417
155MTOR0.26015775
156CDK60.25746108
157PRKCH0.25416606
158CSF1R0.23526326
159ZAP700.23320014
160PASK0.23008800
161IKBKE0.22696607
162MAP3K60.22550552
163PHKG20.21945330
164PHKG10.21945330
165STK390.21101234
166PRKACA0.20642969

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary bile acid biosynthesis_Homo sapiens_hsa001204.12209357
2Nitrogen metabolism_Homo sapiens_hsa009103.33413273
3Ascorbate and aldarate metabolism_Homo sapiens_hsa000533.32581742
4Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004003.32034277
5Arginine biosynthesis_Homo sapiens_hsa002202.90665631
6Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006302.75664517
7Tryptophan metabolism_Homo sapiens_hsa003802.73899455
8Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.58779820
9Fatty acid degradation_Homo sapiens_hsa000712.57401155
10Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010402.52808532
11Glycine, serine and threonine metabolism_Homo sapiens_hsa002602.49080979
12Complement and coagulation cascades_Homo sapiens_hsa046102.39382884
13Butanoate metabolism_Homo sapiens_hsa006502.38636739
14Pentose and glucuronate interconversions_Homo sapiens_hsa000402.29173435
15Peroxisome_Homo sapiens_hsa041462.16225745
16Propanoate metabolism_Homo sapiens_hsa006402.11294794
17Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.95604338
18Fatty acid metabolism_Homo sapiens_hsa012121.84974825
192-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.81245022
20Histidine metabolism_Homo sapiens_hsa003401.80868219
21PPAR signaling pathway_Homo sapiens_hsa033201.79626848
22Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.78953729
23Steroid hormone biosynthesis_Homo sapiens_hsa001401.72370254
24beta-Alanine metabolism_Homo sapiens_hsa004101.71708880
25Chemical carcinogenesis_Homo sapiens_hsa052041.71327051
26Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.68522298
27Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.68271949
28DNA replication_Homo sapiens_hsa030301.66692072
29Maturity onset diabetes of the young_Homo sapiens_hsa049501.66334351
30Selenocompound metabolism_Homo sapiens_hsa004501.66244537
31Sulfur metabolism_Homo sapiens_hsa009201.65949295
32Drug metabolism - other enzymes_Homo sapiens_hsa009831.64449246
33Pyruvate metabolism_Homo sapiens_hsa006201.57397118
34Phenylalanine metabolism_Homo sapiens_hsa003601.55198323
35Caffeine metabolism_Homo sapiens_hsa002321.54593535
36Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.52765250
37Bile secretion_Homo sapiens_hsa049761.50109757
38Retinol metabolism_Homo sapiens_hsa008301.47734939
39Starch and sucrose metabolism_Homo sapiens_hsa005001.43948736
40Staphylococcus aureus infection_Homo sapiens_hsa051501.43467588
41Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.40825596
42Mismatch repair_Homo sapiens_hsa034301.35330054
43Tyrosine metabolism_Homo sapiens_hsa003501.32233717
44Fatty acid elongation_Homo sapiens_hsa000621.32011252
45Ribosome_Homo sapiens_hsa030101.31319733
46Carbon metabolism_Homo sapiens_hsa012001.29441175
47Folate biosynthesis_Homo sapiens_hsa007901.28493788
48Biosynthesis of amino acids_Homo sapiens_hsa012301.27003851
49Cysteine and methionine metabolism_Homo sapiens_hsa002701.25754793
50Cyanoamino acid metabolism_Homo sapiens_hsa004601.20064744
51ABC transporters_Homo sapiens_hsa020101.16779343
52Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.14088159
53Fat digestion and absorption_Homo sapiens_hsa049751.11491344
54Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.06530402
55Arginine and proline metabolism_Homo sapiens_hsa003301.05272229
56Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.04838393
57Steroid biosynthesis_Homo sapiens_hsa001001.02427001
58Vitamin digestion and absorption_Homo sapiens_hsa049770.99690305
59Sulfur relay system_Homo sapiens_hsa041220.93180525
60Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.92168784
61Base excision repair_Homo sapiens_hsa034100.88696493
62Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.87786368
63Lysine degradation_Homo sapiens_hsa003100.86734750
64Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.78146501
65Homologous recombination_Homo sapiens_hsa034400.72452604
66Glycerolipid metabolism_Homo sapiens_hsa005610.71479181
67Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.71166381
68Vitamin B6 metabolism_Homo sapiens_hsa007500.70863724
69Glutathione metabolism_Homo sapiens_hsa004800.69017140
70Pyrimidine metabolism_Homo sapiens_hsa002400.68487956
71Pentose phosphate pathway_Homo sapiens_hsa000300.64113110
72One carbon pool by folate_Homo sapiens_hsa006700.62583439
73Parkinsons disease_Homo sapiens_hsa050120.61676952
74Nucleotide excision repair_Homo sapiens_hsa034200.55949183
75Metabolic pathways_Homo sapiens_hsa011000.51115888
76Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.49229459
77N-Glycan biosynthesis_Homo sapiens_hsa005100.48856390
78Fructose and mannose metabolism_Homo sapiens_hsa000510.47661453
79Fanconi anemia pathway_Homo sapiens_hsa034600.47273696
80Spliceosome_Homo sapiens_hsa030400.46009999
81Galactose metabolism_Homo sapiens_hsa000520.44998588
82Huntingtons disease_Homo sapiens_hsa050160.41165470
83Proteasome_Homo sapiens_hsa030500.36235358
84Insulin resistance_Homo sapiens_hsa049310.35048719
85Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.33826984
86Alzheimers disease_Homo sapiens_hsa050100.31689721
87RNA polymerase_Homo sapiens_hsa030200.30818670
88Fatty acid biosynthesis_Homo sapiens_hsa000610.30791614
89Prion diseases_Homo sapiens_hsa050200.27947623
90Non-homologous end-joining_Homo sapiens_hsa034500.27820316
91Purine metabolism_Homo sapiens_hsa002300.26345545
92RNA transport_Homo sapiens_hsa030130.26312396
93Adipocytokine signaling pathway_Homo sapiens_hsa049200.25924340
94Glucagon signaling pathway_Homo sapiens_hsa049220.22707339
95alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.22651081
96Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.17522497
97Linoleic acid metabolism_Homo sapiens_hsa005910.15931062
98Glycerophospholipid metabolism_Homo sapiens_hsa005640.12466168
99Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.10847774
100AMPK signaling pathway_Homo sapiens_hsa041520.08778555
101Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.04285826
102Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.03158391
103Glycosaminoglycan degradation_Homo sapiens_hsa005310.01088484
104Regulation of autophagy_Homo sapiens_hsa041400.00157660
105Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa00534-0.1552464
106Mineral absorption_Homo sapiens_hsa04978-0.1525349
107Oxidative phosphorylation_Homo sapiens_hsa00190-0.1477682
108Protein digestion and absorption_Homo sapiens_hsa04974-0.1392474
109Type II diabetes mellitus_Homo sapiens_hsa04930-0.1355824
110Arachidonic acid metabolism_Homo sapiens_hsa00590-0.1306841
111Ovarian steroidogenesis_Homo sapiens_hsa04913-0.1298094
112Central carbon metabolism in cancer_Homo sapiens_hsa05230-0.1237822
113Other glycan degradation_Homo sapiens_hsa00511-0.0920426
114Lysosome_Homo sapiens_hsa04142-0.0820765
115Thyroid hormone synthesis_Homo sapiens_hsa04918-0.0695364
116* Carbohydrate digestion and absorption_Homo sapiens_hsa04973-0.0692909
117Protein export_Homo sapiens_hsa03060-0.0680035
118Renin-angiotensin system_Homo sapiens_hsa04614-0.0487218
119Insulin signaling pathway_Homo sapiens_hsa04910-0.0253352
120Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604-0.0213968

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