SLC38A1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: Amino acid transporters play essential roles in the uptake of nutrients, production of energy, chemical metabolism, detoxification, and neurotransmitter cycling. SLC38A1 is an important transporter of glutamine, an intermediate in the detoxification of ammonia and the production of urea. Glutamine serves as a precursor for the synaptic transmitter, glutamate (Gu et al., 2001 [PubMed 11325958]). NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1pore complex assembly (GO:0046931)5.15207743
2mitotic sister chromatid cohesion (GO:0007064)5.09927452
3synaptic vesicle maturation (GO:0016188)4.91737524
4pre-miRNA processing (GO:0031054)4.47780994
5regulation of centriole replication (GO:0046599)4.08146185
6regulation of short-term neuronal synaptic plasticity (GO:0048172)3.99543309
7locomotory exploration behavior (GO:0035641)3.90214781
8establishment of integrated proviral latency (GO:0075713)3.80294996
9protein localization to kinetochore (GO:0034501)3.80216383
10sodium ion export (GO:0071436)3.79023459
11negative regulation of DNA repair (GO:0045738)3.78346810
12DNA topological change (GO:0006265)3.73386154
13regulation of histone H3-K27 methylation (GO:0061085)3.72044323
14histone H4-K5 acetylation (GO:0043981)3.67039321
15histone H4-K8 acetylation (GO:0043982)3.67039321
16mitotic nuclear envelope disassembly (GO:0007077)3.65653629
17regulation of RNA export from nucleus (GO:0046831)3.62952955
18mitotic chromosome condensation (GO:0007076)3.60904988
19ribosome assembly (GO:0042255)3.60790767
20positive regulation of synapse maturation (GO:0090129)3.60747709
21proline transport (GO:0015824)3.58584081
22positive regulation of calcium ion-dependent exocytosis (GO:0045956)3.54220317
23nuclear envelope disassembly (GO:0051081)3.49802905
24membrane disassembly (GO:0030397)3.49802905
25protein complex localization (GO:0031503)3.49362506
26cellular potassium ion homeostasis (GO:0030007)3.47998206
27regulation of translational fidelity (GO:0006450)3.47827919
28non-recombinational repair (GO:0000726)3.47123300
29double-strand break repair via nonhomologous end joining (GO:0006303)3.47123300
30glutamate secretion (GO:0014047)3.44247310
31V(D)J recombination (GO:0033151)3.43408427
32regulation of attachment of spindle microtubules to kinetochore (GO:0051988)3.42090285
33cellular protein complex localization (GO:0034629)3.39048389
34layer formation in cerebral cortex (GO:0021819)3.38998463
35histone H4-K12 acetylation (GO:0043983)3.38041145
36DNA strand elongation involved in DNA replication (GO:0006271)3.30521529
37histone H4-K16 acetylation (GO:0043984)3.29965052
38synaptic vesicle exocytosis (GO:0016079)3.28793923
39cerebellar Purkinje cell differentiation (GO:0021702)3.24301910
40positive regulation of excitatory postsynaptic membrane potential (GO:2000463)3.24150786
41DNA unwinding involved in DNA replication (GO:0006268)3.21577761
42DNA strand elongation (GO:0022616)3.20723288
43sister chromatid segregation (GO:0000819)3.18847896
44mitotic sister chromatid segregation (GO:0000070)3.17679007
45neurotransmitter secretion (GO:0007269)3.16248941
46spliceosomal tri-snRNP complex assembly (GO:0000244)3.09407469
47synaptic vesicle docking involved in exocytosis (GO:0016081)3.08572502
48vocalization behavior (GO:0071625)3.07883646
49mitotic metaphase plate congression (GO:0007080)3.07802675
50regulation of centrosome duplication (GO:0010824)3.07021176
51nuclear-transcribed mRNA poly(A) tail shortening (GO:0000289)3.05993254
52regulation of nucleobase-containing compound transport (GO:0032239)3.04566960
53DNA conformation change (GO:0071103)3.03192965
54negative regulation of telomerase activity (GO:0051974)3.02188549
55peptidyl-arginine omega-N-methylation (GO:0035247)2.98224100
56regulation of helicase activity (GO:0051095)2.98065816
57regulation of synaptic vesicle exocytosis (GO:2000300)2.97931566
58nuclear pore complex assembly (GO:0051292)2.97540876
59response to pheromone (GO:0019236)2.96955711
60bundle of His cell to Purkinje myocyte communication (GO:0086069)2.95509131
61regulation of NFAT protein import into nucleus (GO:0051532)2.93794456
62regulation of centrosome cycle (GO:0046605)2.92749044
63establishment of nucleus localization (GO:0040023)2.92256346
64regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act2.91748815
65nuclear envelope organization (GO:0006998)2.91612548
66cerebellar granule cell differentiation (GO:0021707)2.90343859
67DNA double-strand break processing (GO:0000729)2.88138258
68positive regulation of cell cycle checkpoint (GO:1901978)2.87748655
69DNA replication initiation (GO:0006270)2.85643428
70protein export from nucleus (GO:0006611)2.84762322
71cytoplasmic mRNA processing body assembly (GO:0033962)2.83686978
72protein localization to chromosome, centromeric region (GO:0071459)2.83184270
73regulation of sister chromatid cohesion (GO:0007063)2.83180299
74negative regulation of chromosome segregation (GO:0051985)2.82860086
75regulation of telomere maintenance via telomerase (GO:0032210)2.82716900
76peptidyl-arginine methylation (GO:0018216)2.82453548
77peptidyl-arginine N-methylation (GO:0035246)2.82453548
78somatic diversification of immune receptors via germline recombination within a single locus (GO:0002.81891198
79somatic cell DNA recombination (GO:0016444)2.81891198
80metaphase plate congression (GO:0051310)2.81234721
81polyketide metabolic process (GO:0030638)2.79866224
82doxorubicin metabolic process (GO:0044598)2.79866224
83daunorubicin metabolic process (GO:0044597)2.79866224
84RNA-dependent DNA replication (GO:0006278)2.79654789
85regulation of inhibitory postsynaptic membrane potential (GO:0060080)2.79649426
86DNA replication checkpoint (GO:0000076)2.79127971
87spindle checkpoint (GO:0031577)2.78378013
88mitotic spindle checkpoint (GO:0071174)2.77945418
89establishment of viral latency (GO:0019043)2.77409769
90maintenance of protein location in nucleus (GO:0051457)2.76799683
91negative regulation of mitotic metaphase/anaphase transition (GO:0045841)2.75672844
92negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)2.75672844
93negative regulation of mitotic sister chromatid segregation (GO:0033048)2.75672844
94negative regulation of mitotic sister chromatid separation (GO:2000816)2.75672844
95negative regulation of sister chromatid segregation (GO:0033046)2.75672844
96regulation of chromosome segregation (GO:0051983)2.75023005
97intestinal epithelial cell development (GO:0060576)2.74897739
98regulation of glutamate receptor signaling pathway (GO:1900449)2.74824223
99response to X-ray (GO:0010165)2.74621202
100mRNA transport (GO:0051028)2.73392724
101positive regulation of keratinocyte differentiation (GO:0045618)2.71894279
102NLS-bearing protein import into nucleus (GO:0006607)2.71364038
103regulation of DNA endoreduplication (GO:0032875)2.71056407
104protein localization to synapse (GO:0035418)2.71037282
105regulation of metaphase/anaphase transition of cell cycle (GO:1902099)2.70474688
106regulation of mitotic metaphase/anaphase transition (GO:0030071)2.70474688
107positive regulation of chromosome segregation (GO:0051984)2.70277675
108regulation of intracellular estrogen receptor signaling pathway (GO:0033146)2.69228862
109negative regulation of G2/M transition of mitotic cell cycle (GO:0010972)2.68864811
110negative regulation of mRNA splicing, via spliceosome (GO:0048025)2.68824180
111positive regulation of synaptic transmission, dopaminergic (GO:0032226)2.68459104
112ATP-dependent chromatin remodeling (GO:0043044)2.68115005
113telomere maintenance via semi-conservative replication (GO:0032201)2.67943751
114exploration behavior (GO:0035640)2.67644745
115negative regulation of mRNA metabolic process (GO:1903312)2.67517755
116nuclear pore organization (GO:0006999)2.67252159
117negative regulation of cell cycle G2/M phase transition (GO:1902750)2.66021292
118regulation of mitotic spindle organization (GO:0060236)2.65767976
119hemidesmosome assembly (GO:0031581)2.64832239
120regulation of mitotic sister chromatid separation (GO:0010965)2.64601603
121regulation of mitotic sister chromatid segregation (GO:0033047)2.64601603
122regulation of sister chromatid segregation (GO:0033045)2.64601603
123mitotic recombination (GO:0006312)2.64278053
124heterochromatin organization (GO:0070828)2.64143833
125histone arginine methylation (GO:0034969)2.63876495
126DNA ligation (GO:0006266)2.63438966
127positive regulation of gene expression, epigenetic (GO:0045815)2.63437722
128stress granule assembly (GO:0034063)2.62858248
129mitotic spindle assembly checkpoint (GO:0007094)2.62361385
130negative regulation of histone methylation (GO:0031061)2.62106165
131regulation of histone H3-K9 methylation (GO:0051570)2.62102381
132L-serine metabolic process (GO:0006563)2.61455321
133positive regulation of intracellular steroid hormone receptor signaling pathway (GO:0033145)2.60662259
134folic acid-containing compound biosynthetic process (GO:0009396)2.60652911
135protein localization to microtubule (GO:0035372)2.59446159
136DNA duplex unwinding (GO:0032508)2.59067564
137regulation of synaptic vesicle transport (GO:1902803)2.58567939
138negative regulation of DNA recombination (GO:0045910)2.58554034
139spindle assembly checkpoint (GO:0071173)2.58295634
140ER overload response (GO:0006983)2.57348142
141nucleosome disassembly (GO:0006337)2.56757997
142protein-DNA complex disassembly (GO:0032986)2.56757997
143gamma-aminobutyric acid transport (GO:0015812)2.56390556
144regulation of DNA damage checkpoint (GO:2000001)2.56120051
145somatic recombination of immunoglobulin gene segments (GO:0016447)2.56055717
146telomere maintenance via recombination (GO:0000722)2.56022428
147tRNA aminoacylation for protein translation (GO:0006418)2.55942864
148negative regulation of mRNA processing (GO:0050686)2.55585256
149DNA geometric change (GO:0032392)2.55031167
150regulation of spindle organization (GO:0090224)2.54588730
151negative regulation of microtubule polymerization (GO:0031115)2.54104614
152glucocorticoid receptor signaling pathway (GO:0042921)2.53508417
153histone H3-K4 methylation (GO:0051568)2.52788209
154RNA stabilization (GO:0043489)2.52466164
155mRNA stabilization (GO:0048255)2.52466164
156G-protein coupled glutamate receptor signaling pathway (GO:0007216)2.52265987
157ionotropic glutamate receptor signaling pathway (GO:0035235)2.51002114
158long-term memory (GO:0007616)2.50348815
159synaptic transmission, glutamatergic (GO:0035249)2.49882057
160synaptic vesicle endocytosis (GO:0048488)2.47071499
161cell differentiation in hindbrain (GO:0021533)2.46018116
162histone H4 acetylation (GO:0043967)2.45229182
163regulation of nuclear cell cycle DNA replication (GO:0033262)2.43058386
164cell communication by electrical coupling involved in cardiac conduction (GO:0086064)2.42247951
165cell communication by electrical coupling (GO:0010644)2.41627121
166peptidyl-lysine dimethylation (GO:0018027)2.39910372
167regulation of telomere maintenance (GO:0032204)2.39687808
168auditory behavior (GO:0031223)2.37359282
169regulation of synapse maturation (GO:0090128)2.37189314
170regulation of synapse structural plasticity (GO:0051823)2.36586554
171* neurotransmitter transport (GO:0006836)2.35748730
172somite rostral/caudal axis specification (GO:0032525)2.34532984
173neuron-neuron synaptic transmission (GO:0007270)2.34100782
174glutamate receptor signaling pathway (GO:0007215)2.34083234
175regulation of mammary gland epithelial cell proliferation (GO:0033599)2.33687117
176regulation of long-term neuronal synaptic plasticity (GO:0048169)2.32753417
177histone H3-K4 trimethylation (GO:0080182)2.32131592
178response to auditory stimulus (GO:0010996)2.31548875
179cell migration in hindbrain (GO:0021535)2.31272844
180neuromuscular process controlling balance (GO:0050885)2.30930128
181potassium ion homeostasis (GO:0055075)2.30879183
182chromatin assembly (GO:0031497)2.28057220
183intracellular estrogen receptor signaling pathway (GO:0030520)2.27522572
184DNA replication-dependent nucleosome assembly (GO:0006335)2.27011102
185DNA replication-dependent nucleosome organization (GO:0034723)2.27011102

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human6.18575807
2MYC_22102868_ChIP-Seq_BL_Human3.30839798
3SALL1_21062744_ChIP-ChIP_HESCs_Human3.16621824
4AR_21909140_ChIP-Seq_LNCAP_Human3.05981546
5FOXM1_23109430_ChIP-Seq_U2OS_Human3.01101676
6RBPJ_22232070_ChIP-Seq_NCS_Mouse3.00329809
7EGR1_19374776_ChIP-ChIP_THP-1_Human2.90279030
8EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse2.86838128
9ZFP281_18358816_ChIP-ChIP_MESCs_Mouse2.57869366
10* E2F4_17652178_ChIP-ChIP_JURKAT_Human2.42537768
11ZFP322A_24550733_ChIP-Seq_MESCs_Mouse2.41488605
12ZFP281_18757296_ChIP-ChIP_E14_Mouse2.41322047
13TP63_17297297_ChIP-ChIP_HaCaT_Human2.40548560
14TP63_19390658_ChIP-ChIP_HaCaT_Human2.35149126
15ZFP281_27345836_Chip-Seq_ESCs_Mouse2.24423155
16SMAD3_22036565_ChIP-Seq_ESCs_Mouse2.23846673
17EZH2_22144423_ChIP-Seq_EOC_Human2.11719883
18IKZF1_21737484_ChIP-ChIP_HCT116_Human2.10921209
19MYC_19030024_ChIP-ChIP_MESCs_Mouse2.10448947
20RARB_27405468_Chip-Seq_BRAIN_Mouse2.09859077
21SMAD4_19686287_ChIP-ChIP_HaCaT_Human2.07977492
22PADI4_21655091_ChIP-ChIP_MCF-7_Human2.07282145
23NELFA_20434984_ChIP-Seq_ESCs_Mouse2.02680316
24SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.95125355
25* KDM2B_26808549_Chip-Seq_SUP-B15_Human1.92757774
26KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.91553831
27KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.91553831
28KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.91553831
29MYCN_18555785_ChIP-Seq_MESCs_Mouse1.91259603
30PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.88188661
31CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.86422721
32HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.85072269
33NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.82316033
34* TCF7_22412390_ChIP-Seq_EML_Mouse1.77050706
35PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.76087290
36KDM2B_26808549_Chip-Seq_DND41_Human1.75794396
37* ELK1_19687146_ChIP-ChIP_HELA_Human1.75743594
38KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.75338876
39ZFX_18555785_ChIP-Seq_MESCs_Mouse1.74126035
40MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.68603586
41REST_21632747_ChIP-Seq_MESCs_Mouse1.66007428
42SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.64749497
43WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.64253593
44ESR1_20079471_ChIP-ChIP_T-47D_Human1.63823550
45CIITA_25753668_ChIP-Seq_RAJI_Human1.61839800
46DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.61428594
47REST_18959480_ChIP-ChIP_MESCs_Mouse1.60633900
48CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.58622733
49CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.57327607
50FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.57140212
51SOX2_18358816_ChIP-ChIP_MESCs_Mouse1.56808787
52KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.56470807
53* KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.55921772
54CREB1_15753290_ChIP-ChIP_HEK293T_Human1.55907210
55CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.55197483
56TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.54709977
57RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.53613894
58MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.53492438
59* KDM2B_26808549_Chip-Seq_K562_Human1.51695093
60KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.51678060
61NACC1_18358816_ChIP-ChIP_MESCs_Mouse1.51518948
62POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.49682156
63BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.47138199
64ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.46657169
65* STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.46079658
66* CHD1_26751641_Chip-Seq_LNCaP_Human1.42291495
67MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.41967959
68DCP1A_22483619_ChIP-Seq_HELA_Human1.40788954
69* NANOG_18347094_ChIP-ChIP_MESCs_Mouse1.39955318
70MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.39720429
71* KDM2B_26808549_Chip-Seq_JURKAT_Human1.37615912
72VDR_21846776_ChIP-Seq_THP-1_Human1.37416862
73EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.35573641
74BP1_19119308_ChIP-ChIP_Hs578T_Human1.35239283
75FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.33476414
76MYC_18358816_ChIP-ChIP_MESCs_Mouse1.32311954
77MYC_19079543_ChIP-ChIP_MESCs_Mouse1.31492116
78KDM5A_27292631_Chip-Seq_BREAST_Human1.30793822
79DROSHA_22980978_ChIP-Seq_HELA_Human1.29980376
80ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.29277473
81* TFAP2A_17053090_ChIP-ChIP_MCF-7_Human1.26737958
82* ZNF217_24962896_ChIP-Seq_MCF-7_Human1.26400120
83FOXP3_21729870_ChIP-Seq_TREG_Human1.26357575
84* RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.24877353
85SOX2_19030024_ChIP-ChIP_MESCs_Mouse1.24875711
86PKCTHETA_26484144_Chip-Seq_BREAST_Human1.24183832
87ZNF263_19887448_ChIP-Seq_K562_Human1.22793436
88SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.22003692
89SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.22003692
90XRN2_22483619_ChIP-Seq_HELA_Human1.21403435
91RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.18337923
92* E2F1_17053090_ChIP-ChIP_MCF-7_Human1.18067751
93POU5F1_16518401_ChIP-PET_MESCs_Mouse1.17989568
94NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.17144159
95KLF4_18555785_ChIP-Seq_MESCs_Mouse1.16513995
96FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human1.16091247
97* EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.16025568
98EST1_17652178_ChIP-ChIP_JURKAT_Human1.15283291
99TCF3_18692474_ChIP-Seq_MESCs_Mouse1.14903603
100* KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.12922183
101GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.12529951
102NOTCH1_21737748_ChIP-Seq_TLL_Human1.12472865
103TCF3_18347094_ChIP-ChIP_MESCs_Mouse1.10237184
104DNAJC2_21179169_ChIP-ChIP_NT2_Human1.09990721
105* E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.09498438
106ESR1_15608294_ChIP-ChIP_MCF-7_Human1.07565360
107NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.06409049
108GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.06261474
109* RING1B_27294783_Chip-Seq_NPCs_Mouse1.05962058
110SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.05612009
111EWS_26573619_Chip-Seq_HEK293_Human1.05539712
112HOXB4_20404135_ChIP-ChIP_EML_Mouse1.03768565
113POU5F1_18347094_ChIP-ChIP_MESCs_Mouse1.03464898
114CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse1.03297661
115TTF2_22483619_ChIP-Seq_HELA_Human1.01214087
116EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.00942056
117UTX_26944678_Chip-Seq_JUKART_Human1.00794413
118SPI1_23127762_ChIP-Seq_K562_Human1.00769604
119RNF2_18974828_ChIP-Seq_MESCs_Mouse1.00767718
120EZH2_18974828_ChIP-Seq_MESCs_Mouse1.00767718
121* EOMES_20176728_ChIP-ChIP_TSCs_Mouse1.00469500
122VDR_23849224_ChIP-Seq_CD4+_Human1.00421449
123NANOG_18555785_ChIP-Seq_MESCs_Mouse1.00111514
124FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human0.99184025
125SCL_19346495_ChIP-Seq_HPC-7_Human0.98826717
126TBX3_20139965_ChIP-Seq_ESCs_Mouse0.97789500
127THAP11_20581084_ChIP-Seq_MESCs_Mouse0.97423969
128GABP_17652178_ChIP-ChIP_JURKAT_Human0.97163640
129ERG_21242973_ChIP-ChIP_JURKAT_Human0.96897833
130RNF2_27304074_Chip-Seq_ESCs_Mouse0.96563055
131JARID2_20064375_ChIP-Seq_MESCs_Mouse0.95977454
132NANOG_21062744_ChIP-ChIP_HESCs_Human0.95664446
133TBX3_20139965_ChIP-Seq_MESCs_Mouse0.95084007
134DACH1_20351289_ChIP-Seq_MDA-MB-231_Human0.94975298
135NANOG_16153702_ChIP-ChIP_HESCs_Human0.94931844
136ELF5_23300383_ChIP-Seq_T47D_Human0.94766881
137E2F1_18555785_ChIP-Seq_MESCs_Mouse0.94073904
138MYC_18555785_ChIP-Seq_MESCs_Mouse0.92961481
139* E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human0.92716620
140CNOT3_19339689_ChIP-ChIP_MESCs_Mouse0.92644834
141HIF1A_21447827_ChIP-Seq_MCF-7_Human0.92104586
142* FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human0.90184909
143CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse0.89404170
144* FOXM1_26456572_ChIP-Seq_MCF-7_Human0.89188964
145* YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse0.88852102
146ERG_20887958_ChIP-Seq_HPC-7_Mouse0.88396732
147TCF3_18692474_ChIP-Seq_MEFs_Mouse0.88016653
148PRDM14_21183938_ChIP-Seq_MESCs_Mouse0.87688129
149FUS_26573619_Chip-Seq_HEK293_Human0.87068647
150* SOX17_20123909_ChIP-Seq_XEN_Mouse0.86816907
151LXR_22292898_ChIP-Seq_THP-1_Human0.86612585
152STAT6_21828071_ChIP-Seq_BEAS2B_Human0.86456726
153* SIN3A_21632747_ChIP-Seq_MESCs_Mouse0.86241577
154AR_19668381_ChIP-Seq_PC3_Human0.86218878
155AHR_22903824_ChIP-Seq_MCF-7_Human0.85852704
156E2F1_21310950_ChIP-Seq_MCF-7_Human0.85817291
157DPY_21335234_ChIP-Seq_ESCs_Mouse0.85350339
158SUZ12_18692474_ChIP-Seq_MESCs_Mouse0.84570038
159* SMC4_20622854_ChIP-Seq_HELA_Human0.83679640
160SOX2_18555785_ChIP-Seq_MESCs_Mouse0.83373079
161ETS1_20019798_ChIP-Seq_JURKAT_Human0.83203087
162CLOCK_20551151_ChIP-Seq_293T_Human0.82612001
163ASH2L_23239880_ChIP-Seq_MESCs_Mouse0.82373678
164POU5F1_18555785_ChIP-Seq_MESCs_Mouse0.82229785
165NR4A2_19515692_ChIP-ChIP_MN9D_Mouse0.80940226
166SOX2_16153702_ChIP-ChIP_HESCs_Human0.80857991

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity3.96786430
2MP0003693_abnormal_embryo_hatching3.38097026
3MP0003941_abnormal_skin_development3.24241914
4MP0002009_preneoplasia3.16916487
5MP0003122_maternal_imprinting3.01060347
6MP0003121_genomic_imprinting2.55505265
7MP0003635_abnormal_synaptic_transmissio2.51031055
8MP0009046_muscle_twitch2.49113444
9MP0000579_abnormal_nail_morphology2.36506693
10MP0003787_abnormal_imprinting2.35833564
11MP0010234_abnormal_vibrissa_follicle2.31259466
12MP0004858_abnormal_nervous_system2.29965850
13MP0005423_abnormal_somatic_nervous2.23235063
14MP0005394_taste/olfaction_phenotype2.21254459
15MP0005499_abnormal_olfactory_system2.21254459
16MP0002653_abnormal_ependyma_morphology2.20542606
17MP0000569_abnormal_digit_pigmentation2.12754277
18MP0003123_paternal_imprinting2.11240512
19MP0009672_abnormal_birth_weight2.06871207
20MP0008058_abnormal_DNA_repair2.05090504
21MP0008932_abnormal_embryonic_tissue2.00535102
22MP0002796_impaired_skin_barrier1.97719813
23MP0008961_abnormal_basal_metabolism1.97095742
24MP0002063_abnormal_learning/memory/cond1.94135872
25MP0006292_abnormal_olfactory_placode1.93971803
26MP0003890_abnormal_embryonic-extraembry1.93528550
27MP0002064_seizures1.91770213
28MP0000537_abnormal_urethra_morphology1.87105914
29MP0003880_abnormal_central_pattern1.80706155
30MP0009745_abnormal_behavioral_response1.77706685
31MP0003763_abnormal_thymus_physiology1.76143666
32MP0010678_abnormal_skin_adnexa1.75941119
33MP0002572_abnormal_emotion/affect_behav1.68595636
34MP0003705_abnormal_hypodermis_morpholog1.57567231
35MP0004264_abnormal_extraembryonic_tissu1.56721822
36MP0002166_altered_tumor_susceptibility1.56590271
37MP0008569_lethality_at_weaning1.54392085
38MP0008057_abnormal_DNA_replication1.54243274
39MP0000383_abnormal_hair_follicle1.54043865
40MP0002184_abnormal_innervation1.47467983
41MP0003221_abnormal_cardiomyocyte_apopto1.46963407
42MP0004811_abnormal_neuron_physiology1.43971737
43MP0001486_abnormal_startle_reflex1.43846525
44MP0010352_gastrointestinal_tract_polyps1.43018253
45MP0005501_abnormal_skin_physiology1.42303107
46MP0004185_abnormal_adipocyte_glucose1.42181970
47MP0004957_abnormal_blastocyst_morpholog1.39931631
48MP0003566_abnormal_cell_adhesion1.38624162
49MP0004270_analgesia1.38472078
50MP0002877_abnormal_melanocyte_morpholog1.35801080
51MP0002006_tumorigenesis1.32629014
52MP0009697_abnormal_copulation1.31668372
53MP0002272_abnormal_nervous_system1.30948566
54MP0001873_stomach_inflammation1.30603059
55MP0000778_abnormal_nervous_system1.29718554
56MP0010094_abnormal_chromosome_stability1.28955614
57MP0000955_abnormal_spinal_cord1.28684167
58MP0002098_abnormal_vibrissa_morphology1.27549791
59MP0003111_abnormal_nucleus_morphology1.26087865
60MP0000350_abnormal_cell_proliferation1.25221299
61MP0003937_abnormal_limbs/digits/tail_de1.23462440
62MP0000427_abnormal_hair_cycle1.23134547
63MP0002697_abnormal_eye_size1.22757037
64MP0002067_abnormal_sensory_capabilities1.22268361
65MP0003077_abnormal_cell_cycle1.21364358
66MP0001968_abnormal_touch/_nociception1.20846043
67MP0006072_abnormal_retinal_apoptosis1.20840091
68MP0000377_abnormal_hair_follicle1.20832634
69MP0005076_abnormal_cell_differentiation1.19844389
70MP0005551_abnormal_eye_electrophysiolog1.19759843
71MP0002734_abnormal_mechanical_nocicepti1.19560167
72MP0002396_abnormal_hematopoietic_system1.19282174
73MP0003861_abnormal_nervous_system1.15264555
74MP0000627_abnormal_mammary_gland1.15207020
75MP0002909_abnormal_adrenal_gland1.14684392
76MP0001177_atelectasis1.13862327
77MP0001216_abnormal_epidermal_layer1.13338123
78MP0001501_abnormal_sleep_pattern1.13227297
79MP0000490_abnormal_crypts_of1.12305515
80MP0003283_abnormal_digestive_organ1.12018611
81MP0003567_abnormal_fetal_cardiomyocyte1.10874637
82MP0003183_abnormal_peptide_metabolism1.09812435
83MP0002557_abnormal_social/conspecific_i1.09748032
84MP0001188_hyperpigmentation1.08900183
85MP0002152_abnormal_brain_morphology1.08799473
86MP0002882_abnormal_neuron_morphology1.08770531
87MP0005380_embryogenesis_phenotype1.07102654
88MP0001672_abnormal_embryogenesis/_devel1.07102654
89MP0005253_abnormal_eye_physiology1.06934093
90MP0004233_abnormal_muscle_weight1.06396159
91MP0003172_abnormal_lysosome_physiology1.04533204
92MP0001346_abnormal_lacrimal_gland1.04494006
93MP0003786_premature_aging1.03873668
94MP0003984_embryonic_growth_retardation1.03475023
95MP0002084_abnormal_developmental_patter1.03462152
96MP0005621_abnormal_cell_physiology1.03330750
97MP0002088_abnormal_embryonic_growth/wei1.03069803
98MP0001286_abnormal_eye_development1.01897359
99MP0000762_abnormal_tongue_morphology1.00132396
100MP0005623_abnormal_meninges_morphology0.99908505
101MP0000313_abnormal_cell_death0.99140401
102MP0008789_abnormal_olfactory_epithelium0.97674557
103MP0004197_abnormal_fetal_growth/weight/0.96878481
104MP0004885_abnormal_endolymph0.95778921
105MP0008877_abnormal_DNA_methylation0.95722470
106MP0002733_abnormal_thermal_nociception0.94651262
107MP0004924_abnormal_behavior0.94230097
108MP0005386_behavior/neurological_phenoty0.94230097
109MP0004381_abnormal_hair_follicle0.94085337
110MP0008770_decreased_survivor_rate0.93392788
111MP0002085_abnormal_embryonic_tissue0.92747760
112MP0004782_abnormal_surfactant_physiolog0.91666980
113MP0004808_abnormal_hematopoietic_stem0.91194439
114MP0001293_anophthalmia0.89157277
115MP0002019_abnormal_tumor_incidence0.88846358
116MP0001970_abnormal_pain_threshold0.88319652
117MP0001440_abnormal_grooming_behavior0.88227114
118MP0003011_delayed_dark_adaptation0.87924451
119MP0001348_abnormal_lacrimal_gland0.87483042
120MP0003943_abnormal_hepatobiliary_system0.87443987
121MP0003115_abnormal_respiratory_system0.87421959
122MP0001730_embryonic_growth_arrest0.86699743
123MP0001340_abnormal_eyelid_morphology0.86517535
124MP0003938_abnormal_ear_development0.86487007
125MP0000703_abnormal_thymus_morphology0.86276033
126MP0002060_abnormal_skin_morphology0.86240828
127MP0005384_cellular_phenotype0.85754414
128MP0003315_abnormal_perineum_morphology0.84341301
129MP0000428_abnormal_craniofacial_morphol0.84168330
130MP0000631_abnormal_neuroendocrine_gland0.83085886
131MP0002086_abnormal_extraembryonic_tissu0.82926852
132MP0003935_abnormal_craniofacial_develop0.82839830
133MP0001697_abnormal_embryo_size0.82308533
134MP0005391_vision/eye_phenotype0.80792045
135MP0002066_abnormal_motor_capabilities/c0.80014095
136MP0004084_abnormal_cardiac_muscle0.79850204
137MP0002332_abnormal_exercise_endurance0.79406768
138MP0002752_abnormal_somatic_nervous0.79052929
139MP0002081_perinatal_lethality0.78408360
140MP0001849_ear_inflammation0.78341221
141MP0000647_abnormal_sebaceous_gland0.76487238
142MP0004142_abnormal_muscle_tone0.76288118
143MP0002751_abnormal_autonomic_nervous0.75780809
144MP0002089_abnormal_postnatal_growth/wei0.75769027
145MP0008007_abnormal_cellular_replicative0.75266512
146MP0002735_abnormal_chemical_nociception0.74947127
147MP0003119_abnormal_digestive_system0.74916331
148MP0005075_abnormal_melanosome_morpholog0.74659017
149MP0000432_abnormal_head_morphology0.73910464
150MP0002080_prenatal_lethality0.73131420
151MP0002111_abnormal_tail_morphology0.71887997
152MP0003453_abnormal_keratinocyte_physiol0.70974738
153MP0002092_abnormal_eye_morphology0.70085528
154MP0003137_abnormal_impulse_conducting0.69990923
155MP0010630_abnormal_cardiac_muscle0.69877025
156MP0010771_integument_phenotype0.69510651
157MP0010307_abnormal_tumor_latency0.69094071
158MP0001727_abnormal_embryo_implantation0.68953641
159MP0001984_abnormal_olfaction0.68930680
160MP0009703_decreased_birth_body0.68744573
161MP0001191_abnormal_skin_condition0.64378265
162MP0000467_abnormal_esophagus_morphology0.63331813
163MP0005409_darkened_coat_color0.62152512

Predicted human phenotypes

RankGene SetZ-score
1Chromosomal breakage induced by crosslinking agents (HP:0003221)4.08780726
2Chromsome breakage (HP:0040012)4.00430905
3Abnormality of the lower motor neuron (HP:0002366)3.74778033
4Bilateral microphthalmos (HP:0007633)3.55925070
5Ependymoma (HP:0002888)3.29967377
6Abnormality of chromosome stability (HP:0003220)3.04392019
7Abnormality of the astrocytes (HP:0100707)3.04383766
8Astrocytoma (HP:0009592)3.04383766
9Asymmetry of the thorax (HP:0001555)3.04146973
10Deep philtrum (HP:0002002)3.01483630
11Amyotrophic lateral sclerosis (HP:0007354)3.00193100
12Right ventricular cardiomyopathy (HP:0011663)2.96143258
13Febrile seizures (HP:0002373)2.95562826
14Selective tooth agenesis (HP:0001592)2.95127148
15Curly hair (HP:0002212)2.92503193
16Epileptic encephalopathy (HP:0200134)2.85165578
17Renal duplication (HP:0000075)2.79811986
18Termporal pattern (HP:0011008)2.76629737
19Insidious onset (HP:0003587)2.76629737
20Hyperacusis (HP:0010780)2.76246833
21Visual hallucinations (HP:0002367)2.70975737
22Focal seizures (HP:0007359)2.69968620
23Abnormality of the preputium (HP:0100587)2.60287972
24Hepatoblastoma (HP:0002884)2.56892028
25Increased nuchal translucency (HP:0010880)2.54189686
26Neoplasm of the heart (HP:0100544)2.53878298
27Progressive cerebellar ataxia (HP:0002073)2.51006995
28Focal motor seizures (HP:0011153)2.47613777
29Subacute progressive viral hepatitis (HP:0006572)2.44218161
30Neoplasm of striated muscle (HP:0009728)2.43258318
31Pointed chin (HP:0000307)2.42686515
32Papillary thyroid carcinoma (HP:0002895)2.41115190
33Volvulus (HP:0002580)2.40740422
34Horizontal nystagmus (HP:0000666)2.39989715
35Macroorchidism (HP:0000053)2.36304869
36Abnormality of ocular smooth pursuit (HP:0000617)2.32656436
37Glioma (HP:0009733)2.32493116
38Milia (HP:0001056)2.31772011
39Congenital stationary night blindness (HP:0007642)2.31487087
40Deviation of the thumb (HP:0009603)2.29762878
41Absence seizures (HP:0002121)2.29359453
42Gastrointestinal carcinoma (HP:0002672)2.28623350
43Malignant gastrointestinal tract tumors (HP:0006749)2.28623350
44Atonic seizures (HP:0010819)2.28028153
45Cortical dysplasia (HP:0002539)2.27578618
46Colon cancer (HP:0003003)2.25567426
47Micronodular cirrhosis (HP:0001413)2.25049312
48Impaired smooth pursuit (HP:0007772)2.24595058
49Breast carcinoma (HP:0003002)2.23515989
50Meckel diverticulum (HP:0002245)2.23348127
51Cafe-au-lait spot (HP:0000957)2.22587468
52Sparse lateral eyebrow (HP:0005338)2.21935323
53Aplasia/Hypoplasia of the uvula (HP:0010293)2.21570675
54Absent eyelashes (HP:0000561)2.21359406
55Missing ribs (HP:0000921)2.20577307
56Generalized hypotonia (HP:0001290)2.20406311
57High anterior hairline (HP:0009890)2.20082051
58Abnormal lung lobation (HP:0002101)2.17232003
59Genetic anticipation (HP:0003743)2.16778579
60Dialeptic seizures (HP:0011146)2.15198913
61Birth length less than 3rd percentile (HP:0003561)2.14189512
62Biliary tract neoplasm (HP:0100574)2.13630701
63Proximal placement of thumb (HP:0009623)2.13107029
64Small intestinal stenosis (HP:0012848)2.12713161
65Duodenal stenosis (HP:0100867)2.12713161
66Annular pancreas (HP:0001734)2.12698890
67Abnormality of chromosome segregation (HP:0002916)2.11607716
68Spinal cord lesions (HP:0100561)2.11100351
69Syringomyelia (HP:0003396)2.11100351
70Abnormality of the ileum (HP:0001549)2.10700749
71Medulloblastoma (HP:0002885)2.10677830
72Hereditary nonpolyposis colorectal carcinoma (HP:0006716)2.09466248
73Tented upper lip vermilion (HP:0010804)2.09307924
74Rhabdomyosarcoma (HP:0002859)2.09169002
75Septate vagina (HP:0001153)2.08491109
76Cystic hygroma (HP:0000476)2.07839882
77Dysmetric saccades (HP:0000641)2.07589376
78Hemiparesis (HP:0001269)2.07173915
79Microglossia (HP:0000171)2.06596794
80Myokymia (HP:0002411)2.06176276
81Rib fusion (HP:0000902)2.03796766
82Absent eyebrow (HP:0002223)2.03607788
83Atrophy/Degeneration involving motor neurons (HP:0007373)2.02495077
84Diplopia (HP:0000651)2.02178596
85Abnormality of binocular vision (HP:0011514)2.02178596
86Insomnia (HP:0100785)1.99996846
87Sandal gap (HP:0001852)1.98236194
88Overlapping toe (HP:0001845)1.97095854
89Myelodysplasia (HP:0002863)1.96958011
90Transitional cell carcinoma of the bladder (HP:0006740)1.96886119
91Elfin facies (HP:0004428)1.95769983
92Pendular nystagmus (HP:0012043)1.95491306
93Action tremor (HP:0002345)1.95359628
94Papilledema (HP:0001085)1.94481357
95Basal cell carcinoma (HP:0002671)1.94324479
96Truncal ataxia (HP:0002078)1.93728187
97Apathy (HP:0000741)1.92854434
98Abnormal number of incisors (HP:0011064)1.92725306
99Hemiplegia (HP:0002301)1.92719230
100Absent frontal sinuses (HP:0002688)1.92004666
101Skin tags (HP:0010609)1.91900058
102Dyschromatopsia (HP:0007641)1.91116689
103Malignant neoplasm of the central nervous system (HP:0100836)1.90382230
104Dysdiadochokinesis (HP:0002075)1.89347822
105Skull defect (HP:0001362)1.88892999
106Tetraplegia (HP:0002445)1.87611900
107Ankyloglossia (HP:0010296)1.87571080
108Inappropriate behavior (HP:0000719)1.87275318
109Preauricular skin tag (HP:0000384)1.86628034
110Uterine neoplasm (HP:0010784)1.86001105
111Thyroid carcinoma (HP:0002890)1.85987000
112Acute myeloid leukemia (HP:0004808)1.85858257
113Abnormality of the fingertips (HP:0001211)1.85733516
114Depression (HP:0000716)1.85165756
115Abnormality of the carotid arteries (HP:0005344)1.83939068
116Aplasia cutis congenita (HP:0001057)1.82595435
117Amblyopia (HP:0000646)1.80960942
118Open mouth (HP:0000194)1.80890399
119Abnormality of nail color (HP:0100643)1.80587173
120Abnormality of the labia minora (HP:0012880)1.80508768
121Decreased number of large peripheral myelinated nerve fibers (HP:0003387)1.80079089
122Trigonocephaly (HP:0000243)1.79434628
123Partial agenesis of the corpus callosum (HP:0001338)1.77696824
124Overriding aorta (HP:0002623)1.77345879
125Diminished motivation (HP:0000745)1.77259024
126Neuroectodermal neoplasm (HP:0030061)1.77084909
127Neuroepithelial neoplasm (HP:0030063)1.77084909
128Nervous tissue neoplasm (HP:0030060)1.77084909
129Acute lymphatic leukemia (HP:0006721)1.77053596
130Embryonal neoplasm (HP:0002898)1.76726375
131Nephroblastoma (Wilms tumor) (HP:0002667)1.76446872
132Aplasia/Hypoplasia of the sternum (HP:0006714)1.76178138
133Resting tremor (HP:0002322)1.75691687
134Bladder carcinoma (HP:0002862)1.75660254
135Bladder neoplasm (HP:0009725)1.75660254
136IgA deficiency (HP:0002720)1.75349147
137Progressive external ophthalmoplegia (HP:0000590)1.74982834
138Sacral dimple (HP:0000960)1.74763209
139Hand muscle atrophy (HP:0009130)1.73466982
140Failure to thrive in infancy (HP:0001531)1.73365465
141Onycholysis (HP:0001806)1.73056472
142Myelomeningocele (HP:0002475)1.72608252
143Ridged nail (HP:0001807)1.72494287
144Obsessive-compulsive behavior (HP:0000722)1.72335913
145Drooling (HP:0002307)1.71568924
146Excessive salivation (HP:0003781)1.71568924
147Prominent nose (HP:0000448)1.70946211
148Lip pit (HP:0100267)1.69006011
149Intellectual disability, profound (HP:0002187)1.68662859
150Leiomyosarcoma (HP:0100243)1.68417508
151Uterine leiomyosarcoma (HP:0002891)1.68417508
152Attention deficit hyperactivity disorder (HP:0007018)1.67435509
153Viral hepatitis (HP:0006562)1.66963993
154Abnormality of the gastric mucosa (HP:0004295)1.66727628
155Abnormality of the duodenum (HP:0002246)1.66638383
156IgM deficiency (HP:0002850)1.66309481
157Gaze-evoked nystagmus (HP:0000640)1.65991911
158Heterotopia (HP:0002282)1.65795380
159Absent radius (HP:0003974)1.65363044
160Abnormality of the salivary glands (HP:0010286)1.64427225
161Pterygium (HP:0001059)1.64345296
162Short 4th metacarpal (HP:0010044)1.64196521
163Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)1.64196521
164Aplasia/Hypoplasia involving the carpal bones (HP:0006502)1.63790931
165Broad palm (HP:0001169)1.63756553
166Neoplasm of the adrenal cortex (HP:0100641)1.63638484
167Hypopigmentation of the fundus (HP:0007894)1.63420601
168Embryonal renal neoplasm (HP:0011794)1.63203614
169Aqueductal stenosis (HP:0002410)1.62622729
170T lymphocytopenia (HP:0005403)1.62565369
171Large earlobe (HP:0009748)1.61910120
172Abnormal foot bone ossification (HP:0010675)1.61528190
173Choanal atresia (HP:0000453)1.60893634
174Abnormality of oral frenula (HP:0000190)1.60721343
175Multiple enchondromatosis (HP:0005701)1.60570757
176Neoplasm of the oral cavity (HP:0100649)1.59430892
177Neuroblastoma (HP:0003006)1.59204263
178Primitive neuroectodermal tumor (HP:0030065)1.59204263
179Neuroblastic tumors (HP:0004376)1.59204263
180Peripheral primitive neuroectodermal neoplasm (HP:0030067)1.59204263

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CDK125.43082105
2SRPK13.24013528
3MAP3K92.81830631
4EIF2AK32.57526499
5GRK62.51923572
6TRIM282.39158051
7MST1R2.38850375
8GRK52.34920366
9TYRO32.25798361
10MARK12.22510727
11NTRK22.21801941
12EEF2K2.21306905
13BCR2.18170783
14BUB12.17577604
15ALK2.17243938
16SMG12.09521733
17NTRK32.09371094
18MAP3K102.07070494
19LATS12.01249010
20CDC72.00575730
21TAF11.98654844
22SIK21.89903655
23MST41.87799291
24MINK11.84682873
25PBK1.81995964
26SCYL21.81424392
27NEK11.79334028
28MAP3K41.78576436
29EIF2AK11.78376185
30MKNK21.76867767
31MKNK11.67911536
32PAK61.64297163
33EPHA21.54075900
34CSF1R1.48869744
35CAMKK11.46615559
36MAP2K41.35439967
37PASK1.32514211
38STK101.32420053
39BRSK21.29257778
40KSR11.29238584
41WNK11.28418254
42STK38L1.28120974
43PKN21.27184742
44MET1.23266565
45RIPK11.20749004
46NEK61.19705015
47RPS6KA41.19348923
48CDK61.14672177
49PLK41.14008175
50ERN11.13348014
51MARK21.11574337
52FGFR41.10241208
53EIF2AK21.09928466
54PIK3CA1.09626288
55ERBB31.09332922
56WEE11.08784733
57CAMK41.08201749
58PLK31.07589172
59TTK1.04673130
60MATK1.03669414
61NEK20.98936864
62TSSK60.97966689
63AKT30.97315798
64HIPK20.95587848
65MELK0.95112144
66PAK40.94365366
67SIK10.94120222
68DAPK10.92790912
69CDK180.92748787
70MAPK70.92075949
71CDK150.91142128
72CHEK10.90783477
73UHMK10.90320161
74AURKB0.90249044
75NTRK10.89871623
76MAP3K70.89309938
77SIK30.89307293
78TAOK10.88901201
79STK380.88125590
80BRD40.87968361
81STK390.87813036
82FGFR30.86120743
83TNIK0.85718685
84MAP4K10.85683676
85GRK10.85249658
86CDK190.83827240
87CDK11A0.81316700
88FES0.81046599
89TNK20.80636937
90YES10.80553723
91ATM0.79945276
92CDK40.77827933
93CDK50.76323606
94PRPF4B0.75128899
95CDK140.74434909
96AKT20.73977144
97RPS6KB10.73550687
98TRIB30.73550274
99CDK20.72653489
100STK30.72387190
101PNCK0.71172737
102MAPK100.70182160
103CAMK1G0.68678838
104ICK0.68378586
105CHEK20.67879604
106PRKCH0.66635116
107ITK0.65252420
108MAP2K70.64421491
109CDK70.64182663
110NLK0.64070359
111ADRBK20.63963632
112RPS6KB20.63205756
113CASK0.61920895
114ATR0.60456435
115DYRK1A0.59633575
116MTOR0.59577989
117BRSK10.59117464
118TAOK20.57745702
119STK240.57458410
120CLK10.55366221
121PRKCG0.55112933
122ERBB40.54902888
123CDK10.54274683
124PLK10.54262746
125STK110.54002983
126CAMK10.53677187
127BMX0.52933847
128FGFR10.50631235
129DAPK20.49264947
130PLK20.48953312
131GSK3B0.48165888
132MAP3K120.48090961
133ROCK20.47711152
134RPS6KA30.47394900
135MAPK140.46680468
136MAP3K80.46625582
137CDK80.46497997
138PRKG20.46025316
139CSNK1E0.45628425
140MAPK90.45477318
141NUAK10.44720530
142LATS20.44302012
143ADRBK10.43804517
144PDGFRA0.43466082
145MAPK80.42890140
146SGK30.42614669
147BRAF0.42493582
148RET0.42355007
149CDC42BPA0.42198152
150STK40.39043937
151CDK90.38735467
152TTN0.35746273
153FLT30.35039166
154DYRK30.33662143
155PRKDC0.33295982
156TGFBR10.32823134
157FGFR20.32056769
158SGK20.30720384
159MAPK110.29548925
160PDGFRB0.25969103
161CSNK1D0.24461301

Predicted pathways (KEGG)

RankGene SetZ-score
1Non-homologous end-joining_Homo sapiens_hsa034503.57748318
2Nicotine addiction_Homo sapiens_hsa050332.38112217
3Synaptic vesicle cycle_Homo sapiens_hsa047212.09762688
4Long-term potentiation_Homo sapiens_hsa047201.78062809
5Fanconi anemia pathway_Homo sapiens_hsa034601.77849492
6Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.73689498
7* GABAergic synapse_Homo sapiens_hsa047271.71520241
8Adherens junction_Homo sapiens_hsa045201.70070795
9Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.58480514
10Nucleotide excision repair_Homo sapiens_hsa034201.57682211
11Circadian entrainment_Homo sapiens_hsa047131.55374892
12* Glutamatergic synapse_Homo sapiens_hsa047241.52409940
13Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.51911804
14Olfactory transduction_Homo sapiens_hsa047401.50914461
15One carbon pool by folate_Homo sapiens_hsa006701.50773853
16Morphine addiction_Homo sapiens_hsa050321.50554493
17Prostate cancer_Homo sapiens_hsa052151.47592252
18RNA degradation_Homo sapiens_hsa030181.46073051
19mTOR signaling pathway_Homo sapiens_hsa041501.42526212
20Homologous recombination_Homo sapiens_hsa034401.40759148
21Dopaminergic synapse_Homo sapiens_hsa047281.40354155
22Small cell lung cancer_Homo sapiens_hsa052221.38832950
23Base excision repair_Homo sapiens_hsa034101.36847936
24Long-term depression_Homo sapiens_hsa047301.30575585
25mRNA surveillance pathway_Homo sapiens_hsa030151.30463917
26Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.28553288
27Salivary secretion_Homo sapiens_hsa049701.25066116
28p53 signaling pathway_Homo sapiens_hsa041151.24461659
29Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.20474891
30Basal transcription factors_Homo sapiens_hsa030221.19737227
31Colorectal cancer_Homo sapiens_hsa052101.19195749
32Neurotrophin signaling pathway_Homo sapiens_hsa047221.18688179
33Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.17724905
34Phototransduction_Homo sapiens_hsa047441.15922245
35Phosphatidylinositol signaling system_Homo sapiens_hsa040701.15753436
36Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.15659888
37Thyroid hormone signaling pathway_Homo sapiens_hsa049191.14814789
38Oocyte meiosis_Homo sapiens_hsa041141.14325908
39Viral carcinogenesis_Homo sapiens_hsa052031.14140770
40Oxytocin signaling pathway_Homo sapiens_hsa049211.12337349
41Amphetamine addiction_Homo sapiens_hsa050311.12156575
42Cholinergic synapse_Homo sapiens_hsa047251.12143519
43Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.11519854
44Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.09826613
45Biosynthesis of amino acids_Homo sapiens_hsa012301.09632036
46Gastric acid secretion_Homo sapiens_hsa049711.05984465
47Glioma_Homo sapiens_hsa052141.05569105
48Longevity regulating pathway - multiple species_Homo sapiens_hsa042131.03896465
49Non-small cell lung cancer_Homo sapiens_hsa052231.03042955
50Lysine degradation_Homo sapiens_hsa003101.02274546
51Aldosterone synthesis and secretion_Homo sapiens_hsa049251.01891456
52Selenocompound metabolism_Homo sapiens_hsa004500.99875479
53Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.98027984
54GnRH signaling pathway_Homo sapiens_hsa049120.97487326
55Gap junction_Homo sapiens_hsa045400.97364511
56Taste transduction_Homo sapiens_hsa047420.96838771
57T cell receptor signaling pathway_Homo sapiens_hsa046600.95788361
58Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.95247054
59RNA transport_Homo sapiens_hsa030130.95052332
60Central carbon metabolism in cancer_Homo sapiens_hsa052300.94282130
61ErbB signaling pathway_Homo sapiens_hsa040120.94169672
62Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.92550225
63Phospholipase D signaling pathway_Homo sapiens_hsa040720.91916485
64Chronic myeloid leukemia_Homo sapiens_hsa052200.91578465
65Estrogen signaling pathway_Homo sapiens_hsa049150.91430330
66Spliceosome_Homo sapiens_hsa030400.91164234
67Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.91096227
68Insulin secretion_Homo sapiens_hsa049110.88867000
69Endometrial cancer_Homo sapiens_hsa052130.88408386
702-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.87632986
71Hepatitis B_Homo sapiens_hsa051610.86830714
72Cell cycle_Homo sapiens_hsa041100.86490314
73Longevity regulating pathway - mammal_Homo sapiens_hsa042110.85797310
74Serotonergic synapse_Homo sapiens_hsa047260.85647117
75DNA replication_Homo sapiens_hsa030300.85446891
76Renin secretion_Homo sapiens_hsa049240.85376290
77TGF-beta signaling pathway_Homo sapiens_hsa043500.85258390
78Inositol phosphate metabolism_Homo sapiens_hsa005620.85167894
79B cell receptor signaling pathway_Homo sapiens_hsa046620.84933403
80Calcium signaling pathway_Homo sapiens_hsa040200.84575276
81Epstein-Barr virus infection_Homo sapiens_hsa051690.83934267
82MAPK signaling pathway_Homo sapiens_hsa040100.83722750
83cAMP signaling pathway_Homo sapiens_hsa040240.83675458
84Proteasome_Homo sapiens_hsa030500.83131817
85Bladder cancer_Homo sapiens_hsa052190.82525469
86VEGF signaling pathway_Homo sapiens_hsa043700.81878359
87Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.80927337
88Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.80239647
89Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.79539433
90Cysteine and methionine metabolism_Homo sapiens_hsa002700.78859889
91Tight junction_Homo sapiens_hsa045300.78639516
92Vitamin B6 metabolism_Homo sapiens_hsa007500.78534215
93Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.75227529
94Cocaine addiction_Homo sapiens_hsa050300.75065910
95Primary immunodeficiency_Homo sapiens_hsa053400.74445525
96Wnt signaling pathway_Homo sapiens_hsa043100.74397953
97Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.74303376
98Melanogenesis_Homo sapiens_hsa049160.73838373
99Melanoma_Homo sapiens_hsa052180.73810609
100cGMP-PKG signaling pathway_Homo sapiens_hsa040220.72816745
101MicroRNAs in cancer_Homo sapiens_hsa052060.72708307
102Choline metabolism in cancer_Homo sapiens_hsa052310.72168535
103Pancreatic cancer_Homo sapiens_hsa052120.70705771
104Notch signaling pathway_Homo sapiens_hsa043300.70309609
105Type II diabetes mellitus_Homo sapiens_hsa049300.70191720
106Acute myeloid leukemia_Homo sapiens_hsa052210.69469886
107Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.69085799
108Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.68879072
109Rap1 signaling pathway_Homo sapiens_hsa040150.68430077
110Alcoholism_Homo sapiens_hsa050340.67871285
111HTLV-I infection_Homo sapiens_hsa051660.67759694
112Proteoglycans in cancer_Homo sapiens_hsa052050.67489961
113Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.67469159
114N-Glycan biosynthesis_Homo sapiens_hsa005100.66605786
115Mismatch repair_Homo sapiens_hsa034300.65892369
116Pathways in cancer_Homo sapiens_hsa052000.65681565
117Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.65658986
118Hippo signaling pathway_Homo sapiens_hsa043900.65495467
119Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.65489987
120Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.64883128
121Measles_Homo sapiens_hsa051620.64173756
122Renal cell carcinoma_Homo sapiens_hsa052110.63964477
123Axon guidance_Homo sapiens_hsa043600.62907325
124Prolactin signaling pathway_Homo sapiens_hsa049170.62794592
125Basal cell carcinoma_Homo sapiens_hsa052170.61397011
126Thyroid cancer_Homo sapiens_hsa052160.60794925
127RNA polymerase_Homo sapiens_hsa030200.60354500
128Steroid biosynthesis_Homo sapiens_hsa001000.60051106
129FoxO signaling pathway_Homo sapiens_hsa040680.59942291
130Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.59665796
131Fructose and mannose metabolism_Homo sapiens_hsa000510.58735111
132Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.58682650
133Chemokine signaling pathway_Homo sapiens_hsa040620.58438589
134Type I diabetes mellitus_Homo sapiens_hsa049400.57871885
135Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.57711427
136Hedgehog signaling pathway_Homo sapiens_hsa043400.57409362
137Dilated cardiomyopathy_Homo sapiens_hsa054140.57323122
138Transcriptional misregulation in cancer_Homo sapiens_hsa052020.55905850
139Apoptosis_Homo sapiens_hsa042100.55728672
140Insulin signaling pathway_Homo sapiens_hsa049100.55514263
141Endocytosis_Homo sapiens_hsa041440.55379181
142Pyrimidine metabolism_Homo sapiens_hsa002400.55019221
143HIF-1 signaling pathway_Homo sapiens_hsa040660.54434478
144Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.53216849
145Focal adhesion_Homo sapiens_hsa045100.52119881
146Herpes simplex infection_Homo sapiens_hsa051680.51741355
147Hepatitis C_Homo sapiens_hsa051600.49274222
148AMPK signaling pathway_Homo sapiens_hsa041520.48649616
149Regulation of actin cytoskeleton_Homo sapiens_hsa048100.44713564
150Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.42914476
151Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.42063506
152Sphingolipid signaling pathway_Homo sapiens_hsa040710.38499077
153PI3K-Akt signaling pathway_Homo sapiens_hsa041510.36941964

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