SLC38A11

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1positive regulation of phosphoprotein phosphatase activity (GO:0032516)5.14033536
2superoxide anion generation (GO:0042554)4.71990705
3endocardial cushion development (GO:0003197)4.64534419
4negative regulation of Rho protein signal transduction (GO:0035024)3.96290621
5regulation of posttranscriptional gene silencing (GO:0060147)3.91190635
6regulation of gene silencing by miRNA (GO:0060964)3.91190635
7regulation of gene silencing by RNA (GO:0060966)3.91190635
8negative regulation of axon extension involved in axon guidance (GO:0048843)3.90022250
9interkinetic nuclear migration (GO:0022027)3.84413868
10negative regulation of smooth muscle cell migration (GO:0014912)3.83085008
11cell-substrate adherens junction assembly (GO:0007045)3.74305079
12focal adhesion assembly (GO:0048041)3.74305079
13chondrocyte proliferation (GO:0035988)3.70068411
14regulation of hippo signaling (GO:0035330)3.66081192
15tonic smooth muscle contraction (GO:0014820)3.65952882
16positive regulation of uterine smooth muscle contraction (GO:0070474)3.59143277
17cell morphogenesis involved in neuron differentiation (GO:0048667)3.55796106
18negative regulation of fatty acid transport (GO:2000192)3.50222594
19regulation of activation of Janus kinase activity (GO:0010533)3.48490726
20glomerular basement membrane development (GO:0032836)3.46413312
21negative regulation of mast cell activation (GO:0033004)3.46309612
22phagocytosis, recognition (GO:0006910)3.44473011
23positive regulation of endothelial cell apoptotic process (GO:2000353)3.41790837
24daunorubicin metabolic process (GO:0044597)3.36559477
25polyketide metabolic process (GO:0030638)3.36559477
26doxorubicin metabolic process (GO:0044598)3.36559477
27negative regulation of axon guidance (GO:1902668)3.25199446
28developmental pigmentation (GO:0048066)3.24572050
29positive regulation of protein homodimerization activity (GO:0090073)3.21249665
30relaxation of smooth muscle (GO:0044557)3.18839783
31cellular extravasation (GO:0045123)3.18836749
32positive regulation of monocyte chemotaxis (GO:0090026)3.13170655
33G-protein coupled purinergic nucleotide receptor signaling pathway (GO:0035589)3.12467076
34positive regulation of phosphatase activity (GO:0010922)3.11971151
35gamma-aminobutyric acid transport (GO:0015812)3.07807071
36smooth muscle tissue development (GO:0048745)3.05916986
37acrosome assembly (GO:0001675)2.96059480
38lipid translocation (GO:0034204)2.91131739
39phospholipid translocation (GO:0045332)2.91131739
40regulation of axon extension involved in axon guidance (GO:0048841)2.90871685
41positive regulation of T cell migration (GO:2000406)2.90446710
42adenosine metabolic process (GO:0046085)2.87461915
43preassembly of GPI anchor in ER membrane (GO:0016254)2.86629497
44positive regulation of smooth muscle cell migration (GO:0014911)2.86403601
45dendritic cell chemotaxis (GO:0002407)2.85765906
46pericardium development (GO:0060039)2.84577852
47negative regulation of glucose import (GO:0046325)2.84170942
48cGMP-mediated signaling (GO:0019934)2.81358414
49platelet dense granule organization (GO:0060155)2.79915480
50cellular response to interferon-beta (GO:0035458)2.79612346
51mesenchymal cell differentiation involved in renal system development (GO:2001012)2.79524999
52mesenchymal cell differentiation involved in kidney development (GO:0072161)2.79524999
53cytochrome complex assembly (GO:0017004)2.79411647
54cell communication by electrical coupling involved in cardiac conduction (GO:0086064)2.78440953
55regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion (GO2.77634993
56adherens junction assembly (GO:0034333)2.77439862
57regulation of peroxisome proliferator activated receptor signaling pathway (GO:0035358)2.77426717
58nucleotide transmembrane transport (GO:1901679)2.76241530
59smooth muscle contraction (GO:0006939)2.75582052
60GPI anchor biosynthetic process (GO:0006506)2.74887406
61cell migration involved in heart development (GO:0060973)2.73464713
62detection of other organism (GO:0098543)2.73420284
63corticosteroid receptor signaling pathway (GO:0031958)2.72664130
64positive regulation of lymphocyte migration (GO:2000403)2.72324472
65regulation of T cell migration (GO:2000404)2.72190986
66natural killer cell activation involved in immune response (GO:0002323)2.70906521
67branching involved in prostate gland morphogenesis (GO:0060442)2.70567418
68wound healing, spreading of epidermal cells (GO:0035313)2.69977308
69auditory receptor cell differentiation (GO:0042491)2.69704475
70neural crest cell development (GO:0014032)2.68802275
71positive regulation of cGMP metabolic process (GO:0030825)2.67915369
72long-chain fatty acid biosynthetic process (GO:0042759)2.67782683
73regulation of timing of cell differentiation (GO:0048505)2.66676970
74mesenchymal cell development (GO:0014031)2.65483780
75regulation of cardiac muscle contraction by calcium ion signaling (GO:0010882)2.65253214
76urinary tract smooth muscle contraction (GO:0014848)2.64963442
77detection of bacterium (GO:0016045)2.63469697
78positive regulation of CREB transcription factor activity (GO:0032793)2.62349871
79energy homeostasis (GO:0097009)2.61672117
80cell-substrate junction assembly (GO:0007044)2.60673965
81regulation of axon guidance (GO:1902667)2.60592290
82protein targeting to lysosome (GO:0006622)2.60399175
83establishment of protein localization to vacuole (GO:0072666)2.60399175
84protein targeting to vacuole (GO:0006623)2.60399175
85regulation of uterine smooth muscle contraction (GO:0070472)2.60386462
86dendritic cell migration (GO:0036336)2.60182412
87oligosaccharide catabolic process (GO:0009313)2.60086470
88positive regulation of inositol phosphate biosynthetic process (GO:0060732)2.59845897
89glomerular filtration (GO:0003094)2.59211673
90eosinophil chemotaxis (GO:0048245)2.58943906
91respiratory chain complex IV assembly (GO:0008535)2.58603889
92startle response (GO:0001964)2.57807788
93detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)2.57541297
94centriole assembly (GO:0098534)2.56495301
95regulation of cellular extravasation (GO:0002691)2.55692936
96positive regulation of catenin import into nucleus (GO:0035413)2.55132745
97presynaptic membrane assembly (GO:0097105)2.54241111
98renal tubule morphogenesis (GO:0061333)2.54126461
99positive regulation of cardiac muscle cell differentiation (GO:2000727)2.54098304
100histamine secretion (GO:0001821)2.53715421
101DNA synthesis involved in DNA repair (GO:0000731)2.53520730
102superoxide metabolic process (GO:0006801)2.52897619
103collagen fibril organization (GO:0030199)2.52481083
104regulation of granulocyte macrophage colony-stimulating factor production (GO:0032645)2.52456635
105negative regulation of digestive system process (GO:0060457)2.51919986
106GPI anchor metabolic process (GO:0006505)2.51770319
107negative regulation of transcription by competitive promoter binding (GO:0010944)2.51512553
108cellular response to gamma radiation (GO:0071480)2.51311383
109neutrophil activation involved in immune response (GO:0002283)2.51247363
110monocyte chemotaxis (GO:0002548)2.49116208
111neutrophil activation (GO:0042119)2.49098009
112cyclic nucleotide catabolic process (GO:0009214)2.48720028
113positive regulation of fatty acid oxidation (GO:0046321)2.47840404
114sequestering of extracellular ligand from receptor (GO:0035581)2.47757087
115purinergic nucleotide receptor signaling pathway (GO:0035590)2.47051133
116negative regulation of myoblast differentiation (GO:0045662)2.46425106
117positive regulation of dephosphorylation (GO:0035306)2.46205498
118regulation of nuclear cell cycle DNA replication (GO:0033262)2.46199540
119uterus development (GO:0060065)2.45569005
120negative regulation of stress fiber assembly (GO:0051497)2.45298607
121interferon-gamma production (GO:0032609)2.42588805
122negative regulation of cardiac muscle cell apoptotic process (GO:0010667)2.41738709
123positive regulation of muscle hypertrophy (GO:0014742)2.41301871
124positive regulation of cardiac muscle hypertrophy (GO:0010613)2.41301871
125basement membrane organization (GO:0071711)2.40945086
126positive regulation of cAMP-mediated signaling (GO:0043950)2.40597119
127glycosphingolipid catabolic process (GO:0046479)2.40286915
128regulation of mast cell activation (GO:0033003)2.39306897
129positive regulation of defense response to virus by host (GO:0002230)2.38726240
130cartilage development involved in endochondral bone morphogenesis (GO:0060351)2.38609482
131positive regulation of fibroblast migration (GO:0010763)2.37351254
132regulation of cGMP metabolic process (GO:0030823)2.37326430
133dermatan sulfate biosynthetic process (GO:0030208)2.37032987
134neurological system process involved in regulation of systemic arterial blood pressure (GO:0001976)2.35691580
135negative regulation of cytosolic calcium ion concentration (GO:0051481)2.35539915
136metanephric mesenchyme development (GO:0072075)2.34789265
137termination of RNA polymerase III transcription (GO:0006386)2.34137628
138transcription elongation from RNA polymerase III promoter (GO:0006385)2.34137628
139negative regulation of smooth muscle cell differentiation (GO:0051151)2.33998841
140positive regulation of calcium ion import (GO:0090280)2.33235145
141positive regulation of fatty acid beta-oxidation (GO:0032000)2.32767722
142stem cell development (GO:0048864)2.32647363
143nodal signaling pathway (GO:0038092)2.32477149
144replicative senescence (GO:0090399)2.32399526
145relaxation of cardiac muscle (GO:0055119)2.32153104
146positive regulation of cGMP biosynthetic process (GO:0030828)2.31761072
147relaxation of muscle (GO:0090075)2.31756381
148phosphorelay signal transduction system (GO:0000160)2.31652981
149mannosylation (GO:0097502)2.31600689
150regulation of fatty acid beta-oxidation (GO:0031998)2.30995945
151regulation of calcineurin-NFAT signaling cascade (GO:0070884)2.30889759
152kidney mesenchyme development (GO:0072074)2.30716418
153regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum (GO:0010880)2.30275684
154retinal cone cell development (GO:0046549)2.30097553
155ceramide catabolic process (GO:0046514)2.30085833
156regulation of dendritic cell antigen processing and presentation (GO:0002604)2.29947629
157anterior/posterior axis specification, embryo (GO:0008595)2.29240759
158positive regulation of release of sequestered calcium ion into cytosol (GO:0051281)2.28900393
159response to peptidoglycan (GO:0032494)2.28880023
160regulation of interleukin-8 secretion (GO:2000482)2.28597445
161negative regulation of actin filament bundle assembly (GO:0032232)2.27909299
162regulation of antigen processing and presentation (GO:0002577)2.27365323
163positive regulation of T cell chemotaxis (GO:0010820)2.27264007
164regulation of T cell chemotaxis (GO:0010819)2.27264007
165anterograde synaptic vesicle transport (GO:0048490)2.26863255
166eosinophil migration (GO:0072677)2.26672413
167presynaptic membrane organization (GO:0097090)2.26624501
168regulation of lymphocyte migration (GO:2000401)2.26558648
169response to immune response of other organism involved in symbiotic interaction (GO:0052564)2.25996417
170response to host immune response (GO:0052572)2.25996417
171response to interferon-beta (GO:0035456)2.25851833
172negative regulation of systemic arterial blood pressure (GO:0003085)2.25721178
173extracellular negative regulation of signal transduction (GO:1900116)2.24826049
174extracellular regulation of signal transduction (GO:1900115)2.24826049
175regulation of antigen processing and presentation of peptide antigen (GO:0002583)2.23750094
176granulocyte activation (GO:0036230)2.23640070
177chemokine-mediated signaling pathway (GO:0070098)2.22861932
178dentate gyrus development (GO:0021542)2.22732405
179androgen biosynthetic process (GO:0006702)2.22294498
180regulation of lymphocyte chemotaxis (GO:1901623)2.21937406
181regulation of development, heterochronic (GO:0040034)2.21294609
182detection of molecule of bacterial origin (GO:0032490)2.20481632
183regulation of inositol phosphate biosynthetic process (GO:0010919)2.20460830
184DNA integration (GO:0015074)2.20048688
185cAMP catabolic process (GO:0006198)2.19587390
186dopamine transport (GO:0015872)2.16550239
187histamine transport (GO:0051608)2.15833187
188proteasome assembly (GO:0043248)2.15135271
189nucleoside diphosphate catabolic process (GO:0009134)2.15052698
190negative regulation of DNA-dependent DNA replication (GO:2000104)2.14786705
191axon ensheathment in central nervous system (GO:0032291)2.14144781
192central nervous system myelination (GO:0022010)2.14144781

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1GBX2_23144817_ChIP-Seq_PC3_Human3.80204158
2TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse3.54639828
3GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse3.14577825
4ZFP57_27257070_Chip-Seq_ESCs_Mouse2.87824033
5FLI1_27457419_Chip-Seq_LIVER_Mouse2.80313072
6PCGF2_27294783_Chip-Seq_ESCs_Mouse2.70923670
7POU3F2_20337985_ChIP-ChIP_501MEL_Human2.33969533
8BP1_19119308_ChIP-ChIP_Hs578T_Human2.30267282
9HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.28565794
10SUZ12_27294783_Chip-Seq_NPCs_Mouse2.19261897
11BMI1_23680149_ChIP-Seq_NPCS_Mouse2.19236894
12TAF15_26573619_Chip-Seq_HEK293_Human2.15523838
13NFE2_27457419_Chip-Seq_LIVER_Mouse2.10726164
14AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human2.01056320
15TP53_16413492_ChIP-PET_HCT116_Human1.98582397
16FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.96878199
17PCGF2_27294783_Chip-Seq_NPCs_Mouse1.95894343
18ZNF217_24962896_ChIP-Seq_MCF-7_Human1.92426613
19SUZ12_18555785_Chip-Seq_ESCs_Mouse1.91913792
20* CBX2_27304074_Chip-Seq_ESCs_Mouse1.90828878
21* STAT3_18555785_Chip-Seq_ESCs_Mouse1.89705546
22ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.89627527
23EZH2_27294783_Chip-Seq_NPCs_Mouse1.87026781
24* EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.86804282
25P300_19829295_ChIP-Seq_ESCs_Human1.83085071
26* E2F1_18555785_Chip-Seq_ESCs_Mouse1.82812439
27VDR_22108803_ChIP-Seq_LS180_Human1.82639057
28* NANOG_18555785_Chip-Seq_ESCs_Mouse1.82454696
29IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.81529929
30* P53_22387025_ChIP-Seq_ESCs_Mouse1.81347085
31* TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.79456180
32* EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse1.78179906
33* NMYC_18555785_Chip-Seq_ESCs_Mouse1.77433888
34IRF1_19129219_ChIP-ChIP_H3396_Human1.74418999
35EZH2_22144423_ChIP-Seq_EOC_Human1.74414914
36GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.70523841
37* CMYC_18555785_Chip-Seq_ESCs_Mouse1.69167282
38EZH2_18974828_ChIP-Seq_MESCs_Mouse1.68713133
39RNF2_18974828_ChIP-Seq_MESCs_Mouse1.68713133
40* RUNX1_27457419_Chip-Seq_LIVER_Mouse1.68393343
41RNF2_27304074_Chip-Seq_NSC_Mouse1.68358720
42FUS_26573619_Chip-Seq_HEK293_Human1.67691272
43EED_16625203_ChIP-ChIP_MESCs_Mouse1.65517713
44SMAD_19615063_ChIP-ChIP_OVARY_Human1.65085936
45P300_18555785_Chip-Seq_ESCs_Mouse1.64907694
46BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.64467908
47ARNT_22903824_ChIP-Seq_MCF-7_Human1.64070532
48AHR_22903824_ChIP-Seq_MCF-7_Human1.63345611
49IGF1R_20145208_ChIP-Seq_DFB_Human1.61703982
50EP300_21415370_ChIP-Seq_HL-1_Mouse1.60625340
51* SOX2_18555785_Chip-Seq_ESCs_Mouse1.60126041
52* EWS_26573619_Chip-Seq_HEK293_Human1.58124300
53OCT4_18555785_Chip-Seq_ESCs_Mouse1.57367057
54ZFX_18555785_Chip-Seq_ESCs_Mouse1.57277805
55IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.55862934
56* PU1_27457419_Chip-Seq_LIVER_Mouse1.55828831
57IRF8_21731497_ChIP-ChIP_J774_Mouse1.55588404
58ER_23166858_ChIP-Seq_MCF-7_Human1.55226207
59CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.54880013
60DROSHA_22980978_ChIP-Seq_HELA_Human1.53062827
61KLF4_18555785_Chip-Seq_ESCs_Mouse1.51303878
62BCAT_22108803_ChIP-Seq_LS180_Human1.50940244
63IRF8_22096565_ChIP-ChIP_GC-B_Human1.49949468
64SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.49465237
65TAL1_26923725_Chip-Seq_HPCs_Mouse1.49294857
66SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.49032731
67* PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.48274448
68SMAD1_18555785_Chip-Seq_ESCs_Mouse1.47894695
69JARID2_20075857_ChIP-Seq_MESCs_Mouse1.47013801
70* ESRRB_18555785_Chip-Seq_ESCs_Mouse1.46891523
71NRF2_20460467_ChIP-Seq_MEFs_Mouse1.46300773
72NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.46300773
73MTF2_20144788_ChIP-Seq_MESCs_Mouse1.41366342
74JARID2_20064375_ChIP-Seq_MESCs_Mouse1.40512280
75SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.39063730
76PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.38112443
77CRX_20693478_ChIP-Seq_RETINA_Mouse1.36643138
78CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.35323230
79BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.34578470
80CTCF_18555785_Chip-Seq_ESCs_Mouse1.33616324
81CTNNB1_20460455_ChIP-Seq_HCT116_Human1.33499524
82* SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.31890078
83CTBP2_25329375_ChIP-Seq_LNCAP_Human1.31068652
84POU5F1_16153702_ChIP-ChIP_HESCs_Human1.31060727
85PIAS1_25552417_ChIP-Seq_VCAP_Human1.30817478
86* CJUN_26792858_Chip-Seq_BT549_Human1.30566026
87TCF4_23295773_ChIP-Seq_U87_Human1.29717325
88SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.28873572
89TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.28232737
90MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.28043119
91RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.27805777
92AR_25329375_ChIP-Seq_VCAP_Human1.25331321
93CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.25051434
94NR3C1_21868756_ChIP-Seq_MCF10A_Human1.24867419
95SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.24685047
96RNF2_27304074_Chip-Seq_ESCs_Mouse1.24210906
97OCT4_21477851_ChIP-Seq_ESCs_Mouse1.23178196
98EZH2_27304074_Chip-Seq_ESCs_Mouse1.23147699
99PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.23086649
100SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse1.22254783
101SMAD4_21799915_ChIP-Seq_A2780_Human1.21678870
102SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.20672939
103UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.20627921
104RXR_22108803_ChIP-Seq_LS180_Human1.20514400
105CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.19145300
106SMAD3_21741376_ChIP-Seq_HESCs_Human1.18138116
107OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.18057497
108SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.18052063
109CTBP1_25329375_ChIP-Seq_LNCAP_Human1.17500773
110LMO2_26923725_Chip-Seq_MACROPHAGESS_Mouse1.15676284
111ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.15643014
112FOXA2_19822575_ChIP-Seq_HepG2_Human1.15280337
113TP63_19390658_ChIP-ChIP_HaCaT_Human1.15172281
114TOP2B_26459242_ChIP-Seq_MCF-7_Human1.14934614
115ESR1_20079471_ChIP-ChIP_T-47D_Human1.14910784
116RBPJ_22232070_ChIP-Seq_NCS_Mouse1.14600741
117TP53_18474530_ChIP-ChIP_U2OS_Human1.14041878
118NR3C1_23031785_ChIP-Seq_PC12_Mouse1.13578381
119NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.13039102
120WT1_25993318_ChIP-Seq_PODOCYTE_Human1.12297744
121ELF1_17652178_ChIP-ChIP_JURKAT_Human1.11933531
122YAP1_20516196_ChIP-Seq_MESCs_Mouse1.11276368
123BRD4_25478319_ChIP-Seq_HGPS_Human1.11158736
124EZH2_27294783_Chip-Seq_ESCs_Mouse1.10877727
125SMAD3_21741376_ChIP-Seq_EPCs_Human1.10786175
126CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.10620584
127ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.10177458
128NOTCH1_21737748_ChIP-Seq_TLL_Human1.09676533
129CDX2_19796622_ChIP-Seq_MESCs_Mouse1.09636528
130KAP1_22055183_ChIP-Seq_ESCs_Mouse1.09088099
131AR_21572438_ChIP-Seq_LNCaP_Human1.08943210
132GATA2_21666600_ChIP-Seq_HMVEC_Human1.07436053
133SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.07319126
134SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.07142901
135FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.06754398
136MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.06535373
137WT1_19549856_ChIP-ChIP_CCG9911_Human1.06534001
138LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.06008250
139RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.06002625
140JUN_21703547_ChIP-Seq_K562_Human1.05210772
141SOX2_21211035_ChIP-Seq_LN229_Gbm1.04541489
142RUNX2_22187159_ChIP-Seq_PCA_Human1.04488941
143TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.03744160
144ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.03730223
145POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.03082447
146TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.03082447
147* KDM2B_26808549_Chip-Seq_REH_Human1.02588885
148STAT3_23295773_ChIP-Seq_U87_Human1.00610053
149EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human0.99959352

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005503_abnormal_tendon_morphology5.15539943
2MP0004272_abnormal_basement_membrane4.19576151
3MP0001188_hyperpigmentation3.76994040
4MP0009384_cardiac_valve_regurgitation3.46191758
5MP0006292_abnormal_olfactory_placode3.37422437
6MP0008438_abnormal_cutaneous_collagen3.29455439
7MP0003252_abnormal_bile_duct3.11890565
8MP0005171_absent_coat_pigmentation2.92125346
9MP0000015_abnormal_ear_pigmentation2.80353278
10MP0000569_abnormal_digit_pigmentation2.54822885
11MP0005646_abnormal_pituitary_gland2.52208565
12MP0003283_abnormal_digestive_organ2.48302573
13MP0000566_synostosis2.44180176
14MP0009697_abnormal_copulation2.43683223
15MP0003724_increased_susceptibility_to2.39174883
16MP0001661_extended_life_span2.36773877
17MP0002148_abnormal_hypersensitivity_rea2.30618774
18MP0003136_yellow_coat_color2.28605418
19MP0002102_abnormal_ear_morphology2.24935616
20MP0001348_abnormal_lacrimal_gland2.24086723
21MP0006054_spinal_hemorrhage2.24083711
22MP0010386_abnormal_urinary_bladder2.20924272
23MP0001958_emphysema2.19913998
24MP0002108_abnormal_muscle_morphology2.19281397
25MP0003646_muscle_fatigue2.19088915
26MP0004381_abnormal_hair_follicle2.13759778
27MP0003941_abnormal_skin_development2.13699191
28MP0005075_abnormal_melanosome_morpholog2.12405086
29MP0002277_abnormal_respiratory_mucosa2.10548660
30MP0005645_abnormal_hypothalamus_physiol2.10166414
31MP0005085_abnormal_gallbladder_physiolo2.03530534
32MP0005174_abnormal_tail_pigmentation2.01911971
33MP0002876_abnormal_thyroid_physiology1.99008717
34MP0001835_abnormal_antigen_presentation1.98089152
35MP0009785_altered_susceptibility_to1.95800486
36MP0005275_abnormal_skin_tensile1.91543985
37MP0005409_darkened_coat_color1.90057479
38MP0000538_abnormal_urinary_bladder1.89253539
39MP0005671_abnormal_response_to1.81426976
40MP0009379_abnormal_foot_pigmentation1.79156933
41MP0001986_abnormal_taste_sensitivity1.78865287
42MP0000372_irregular_coat_pigmentation1.75571403
43MP0002163_abnormal_gland_morphology1.75019703
44MP0002132_abnormal_respiratory_system1.75006209
45MP0004782_abnormal_surfactant_physiolog1.71959663
46MP0000534_abnormal_ureter_morphology1.71115214
47MP0005257_abnormal_intraocular_pressure1.71087773
48MP0003942_abnormal_urinary_system1.69788590
49MP0000767_abnormal_smooth_muscle1.66862568
50MP0001664_abnormal_digestion1.66528786
51MP0002928_abnormal_bile_duct1.58157730
52MP0003045_fibrosis1.57546640
53MP0009780_abnormal_chondrocyte_physiolo1.57151008
54MP0003868_abnormal_feces_composition1.55237263
55MP0000462_abnormal_digestive_system1.54331337
56MP0003195_calcinosis1.53384221
57MP0001346_abnormal_lacrimal_gland1.50683796
58MP0001501_abnormal_sleep_pattern1.50068003
59MP0000230_abnormal_systemic_arterial1.47585393
60MP0003880_abnormal_central_pattern1.45904720
61MP0002095_abnormal_skin_pigmentation1.45737354
62MP0002638_abnormal_pupillary_reflex1.44962867
63MP0005620_abnormal_muscle_contractility1.41820014
64MP0005379_endocrine/exocrine_gland_phen1.40134627
65MP0004145_abnormal_muscle_electrophysio1.40056087
66MP0009046_muscle_twitch1.39027619
67MP0004036_abnormal_muscle_relaxation1.38176467
68MP0004043_abnormal_pH_regulation1.37615638
69MP0006276_abnormal_autonomic_nervous1.35887834
70MP0008058_abnormal_DNA_repair1.34805455
71MP0002735_abnormal_chemical_nociception1.34542830
72MP0005187_abnormal_penis_morphology1.33823914
73MP0002009_preneoplasia1.33203142
74MP0005000_abnormal_immune_tolerance1.32987390
75MP0002419_abnormal_innate_immunity1.32479525
76MP0005595_abnormal_vascular_smooth1.32282357
77MP0005387_immune_system_phenotype1.30825913
78MP0001790_abnormal_immune_system1.30825913
79MP0001270_distended_abdomen1.29649715
80MP0003787_abnormal_imprinting1.29543793
81MP0010368_abnormal_lymphatic_system1.28908194
82MP0004742_abnormal_vestibular_system1.28142115
83MP0009053_abnormal_anal_canal1.27213440
84MP0009250_abnormal_appendicular_skeleto1.27189242
85MP0005360_urolithiasis1.26378708
86MP0003566_abnormal_cell_adhesion1.25304698
87MP0006082_CNS_inflammation1.24800651
88MP0005508_abnormal_skeleton_morphology1.22757277
89MP0001963_abnormal_hearing_physiology1.21427497
90MP0000681_abnormal_thyroid_gland1.20415155
91MP0001905_abnormal_dopamine_level1.20082613
92MP0002938_white_spotting1.19797913
93MP0003950_abnormal_plasma_membrane1.18250627
94MP0002138_abnormal_hepatobiliary_system1.16779748
95MP0000026_abnormal_inner_ear1.15318785
96MP0002168_other_aberrant_phenotype1.13862927
97MP0001486_abnormal_startle_reflex1.13116870
98MP0001756_abnormal_urination1.11510248
99MP0009764_decreased_sensitivity_to1.11327195
100MP0004147_increased_porphyrin_level1.11169639
101MP0005025_abnormal_response_to1.11167939
102MP0000751_myopathy1.10903402
103MP0001984_abnormal_olfaction1.09892623
104MP0005023_abnormal_wound_healing1.09604778
105MP0001502_abnormal_circadian_rhythm1.09449375
106MP0008789_abnormal_olfactory_epithelium1.07386170
107MP0008057_abnormal_DNA_replication1.07090977
108MP0001186_pigmentation_phenotype1.06696399
109MP0002452_abnormal_antigen_presenting1.04221513
110MP0008260_abnormal_autophagy1.03479318
111MP0001542_abnormal_bone_strength1.03051812
112MP0002115_abnormal_skeleton_extremities1.02055574
113MP0002723_abnormal_immune_serum1.01233749
114MP0001666_abnormal_nutrient_absorption1.00424546
115MP0005551_abnormal_eye_electrophysiolog0.98781973
116MP0008995_early_reproductive_senescence0.98543536
117MP0002177_abnormal_outer_ear0.97802204
118MP0001879_abnormal_lymphatic_vessel0.97446175
119MP0001819_abnormal_immune_cell0.96004754
120MP0001968_abnormal_touch/_nociception0.95315299
121MP0002420_abnormal_adaptive_immunity0.95030676
122MP0000678_abnormal_parathyroid_gland0.93426176
123MP0004134_abnormal_chest_morphology0.92982114
124MP0003705_abnormal_hypodermis_morpholog0.92302389
125MP0005253_abnormal_eye_physiology0.91168277
126MP0002736_abnormal_nociception_after0.90538479
127MP0009745_abnormal_behavioral_response0.90443821
128MP0005220_abnormal_exocrine_pancreas0.89847178
129MP0002295_abnormal_pulmonary_circulatio0.89417739
130MP0001529_abnormal_vocalization0.87705408
131MP0001299_abnormal_eye_distance/0.87626728
132MP0003011_delayed_dark_adaptation0.86728518
133MP0000470_abnormal_stomach_morphology0.86370515
134MP0000013_abnormal_adipose_tissue0.86211932
135MP0003763_abnormal_thymus_physiology0.85749079
136MP0002896_abnormal_bone_mineralization0.85427377
137MP0004133_heterotaxia0.85320421
138MP0004215_abnormal_myocardial_fiber0.84460493
139MP0005310_abnormal_salivary_gland0.84324650
140MP0000049_abnormal_middle_ear0.83392338
141MP0000163_abnormal_cartilage_morphology0.83104416
142MP0006072_abnormal_retinal_apoptosis0.82857808
143MP0003186_abnormal_redox_activity0.82737033
144MP0002272_abnormal_nervous_system0.81775326
145MP0008877_abnormal_DNA_methylation0.81756522
146MP0000613_abnormal_salivary_gland0.80613954
147MP0004142_abnormal_muscle_tone0.80235655
148MP0010329_abnormal_lipoprotein_level0.78349411
149MP0002933_joint_inflammation0.77953511
150MP0003279_aneurysm0.77594155
151MP0002075_abnormal_coat/hair_pigmentati0.77439281
152MP0005084_abnormal_gallbladder_morpholo0.77111361
153MP0000631_abnormal_neuroendocrine_gland0.76462674
154MP0008004_abnormal_stomach_pH0.75651303
155MP0000920_abnormal_myelination0.75247338
156MP0001919_abnormal_reproductive_system0.75129550
157MP0001119_abnormal_female_reproductive0.74867132
158MP0001800_abnormal_humoral_immune0.74860851
159MP0005394_taste/olfaction_phenotype0.74187363
160MP0005499_abnormal_olfactory_system0.74187363
161MP0008775_abnormal_heart_ventricle0.72911673
162MP0000428_abnormal_craniofacial_morphol0.72070376
163MP0000516_abnormal_urinary_system0.71808407
164MP0005367_renal/urinary_system_phenotyp0.71808407
165MP0002109_abnormal_limb_morphology0.71727140
166MP0005408_hypopigmentation0.70622703
167MP0002089_abnormal_postnatal_growth/wei0.70131036
168MP0005389_reproductive_system_phenotype0.70041172
169MP0004130_abnormal_muscle_cell0.69906455
170MP0005197_abnormal_uvea_morphology0.69005498
171MP0002006_tumorigenesis0.68361903
172MP0000749_muscle_degeneration0.68307604
173MP0005164_abnormal_response_to0.67897526
174MP0003718_maternal_effect0.67385671
175MP0004085_abnormal_heartbeat0.67145708
176MP0003635_abnormal_synaptic_transmissio0.66022704
177MP0001764_abnormal_homeostasis0.65900068
178MP0002160_abnormal_reproductive_system0.65469376
179MP0002135_abnormal_kidney_morphology0.64537764
180MP0004270_analgesia0.64338200
181MP0004233_abnormal_muscle_weight0.62629831
182MP0003091_abnormal_cell_migration0.62596506
183MP0002925_abnormal_cardiovascular_devel0.62197734
184MP0005423_abnormal_somatic_nervous0.62142632
185MP0004924_abnormal_behavior0.61562008

Predicted human phenotypes

RankGene SetZ-score
1Aortic aneurysm (HP:0004942)6.37856433
2Aortic dissection (HP:0002647)5.04354772
3Genetic anticipation (HP:0003743)3.83500711
4Chromosomal breakage induced by crosslinking agents (HP:0003221)3.72337349
5Broad metatarsal (HP:0001783)3.67521855
6Protrusio acetabuli (HP:0003179)3.62468237
7Abnormality of the renal collecting system (HP:0004742)3.54265345
8Hyperventilation (HP:0002883)3.46405164
9Optic neuritis (HP:0100653)3.38312086
10Retrobulbar optic neuritis (HP:0100654)3.38312086
11Increased IgM level (HP:0003496)3.33587895
12Chromsome breakage (HP:0040012)3.32900633
13Premature rupture of membranes (HP:0001788)3.32541709
14Vertebral arch anomaly (HP:0008438)3.31427878
15Duplicated collecting system (HP:0000081)3.25391815
16Gaze-evoked nystagmus (HP:0000640)3.11907667
17Congenital stationary night blindness (HP:0007642)2.97720373
18Patchy hypopigmentation of hair (HP:0011365)2.95064125
19Chorioretinal atrophy (HP:0000533)2.94830621
20White forelock (HP:0002211)2.93445376
21Mild short stature (HP:0003502)2.90882307
22Hypothermia (HP:0002045)2.84293701
233-Methylglutaconic aciduria (HP:0003535)2.84145150
24Type I transferrin isoform profile (HP:0003642)2.83749180
25Septo-optic dysplasia (HP:0100842)2.75938684
26Short hallux (HP:0010109)2.74494041
27Progressive cerebellar ataxia (HP:0002073)2.72710610
28Soft skin (HP:0000977)2.71685584
29Abnormal hair whorl (HP:0010721)2.69613401
30Neonatal short-limb short stature (HP:0008921)2.69590996
31Action tremor (HP:0002345)2.65050742
32Preaxial foot polydactyly (HP:0001841)2.65048146
33Pancreatic fibrosis (HP:0100732)2.64120012
34Vascular tortuosity (HP:0004948)2.63492752
35Renal cortical cysts (HP:0000803)2.58082771
36Hypoplastic ischia (HP:0003175)2.56497730
37Decreased central vision (HP:0007663)2.55291663
38Bifid tongue (HP:0010297)2.54389008
39True hermaphroditism (HP:0010459)2.54082100
40Intestinal atresia (HP:0011100)2.53626114
41Medial flaring of the eyebrow (HP:0010747)2.50192435
42Orchitis (HP:0100796)2.47465022
43Hemiplegia (HP:0002301)2.45487751
44Chronic hepatic failure (HP:0100626)2.44733928
45Prostate neoplasm (HP:0100787)2.43308135
46Abnormality of the ischium (HP:0003174)2.43244059
47Abnormal ciliary motility (HP:0012262)2.42638903
48Parakeratosis (HP:0001036)2.38026298
49Aplasia/Hypoplasia of the hallux (HP:0008362)2.35878703
50Aneurysm (HP:0002617)2.35792902
51Recurrent pneumonia (HP:0006532)2.35049849
52Abnormality of incisor morphology (HP:0011063)2.33305903
53Aplasia/Hypoplasia of the pubic bone (HP:0009104)2.33250929
54Recurrent abscess formation (HP:0002722)2.30753381
55Keratoconjunctivitis sicca (HP:0001097)2.30357043
56Increased number of teeth (HP:0011069)2.28885529
57Persistence of primary teeth (HP:0006335)2.27875159
58Prolonged partial thromboplastin time (HP:0003645)2.27329956
59Reduced antithrombin III activity (HP:0001976)2.27327934
60Wide anterior fontanel (HP:0000260)2.27045674
61Hypoplasia of the fovea (HP:0007750)2.26987322
62Aplasia/Hypoplasia of the fovea (HP:0008060)2.26987322
63Aortic regurgitation (HP:0001659)2.25772127
64Hemiparesis (HP:0001269)2.24464590
65Pulmonary artery stenosis (HP:0004415)2.21859249
66Arterial tortuosity (HP:0005116)2.21762564
67Congenital sensorineural hearing impairment (HP:0008527)2.19563209
68Optic nerve hypoplasia (HP:0000609)2.19203608
69Coronal craniosynostosis (HP:0004440)2.19058280
70Dynein arm defect of respiratory motile cilia (HP:0012255)2.16918050
71Absent/shortened dynein arms (HP:0200106)2.16918050
72Peritonitis (HP:0002586)2.16145648
73Prolonged neonatal jaundice (HP:0006579)2.16061867
74Keratoconjunctivitis (HP:0001096)2.14634461
75Abnormal respiratory motile cilium morphology (HP:0005938)2.14632667
76Abnormal respiratory epithelium morphology (HP:0012253)2.14632667
77Osteomalacia (HP:0002749)2.14154854
78Pancreatic cysts (HP:0001737)2.12394963
79Myositis (HP:0100614)2.12000563
80Abnormality of the renal cortex (HP:0011035)2.11632056
81Mitral stenosis (HP:0001718)2.10446912
82Tubulointerstitial nephritis (HP:0001970)2.09823120
83Hypergonadotropic hypogonadism (HP:0000815)2.09290401
84Blue irides (HP:0000635)2.09166210
85Overgrowth (HP:0001548)2.08432646
86Narrow palate (HP:0000189)2.08159329
87Respiratory insufficiency due to defective ciliary clearance (HP:0200073)2.07687536
88Febrile seizures (HP:0002373)2.07336233
89Abnormality of the columella (HP:0009929)2.07304282
90Eczematoid dermatitis (HP:0000976)2.06273255
91Abnormal protein glycosylation (HP:0012346)2.06139821
92Abnormal glycosylation (HP:0012345)2.06139821
93Abnormal isoelectric focusing of serum transferrin (HP:0003160)2.06139821
94Abnormal protein N-linked glycosylation (HP:0012347)2.06139821
95Obstructive lung disease (HP:0006536)2.06083687
96Chronic obstructive pulmonary disease (HP:0006510)2.06083687
97Facial shape deformation (HP:0011334)2.06068145
98Potter facies (HP:0002009)2.06068145
99Metaphyseal dysplasia (HP:0100255)2.05408278
100Flared iliac wings (HP:0002869)2.04289282
101Ankle contracture (HP:0006466)2.03284210
102Abnormality of the renal medulla (HP:0100957)2.03232617
103Nephrogenic diabetes insipidus (HP:0009806)2.03126753
104Fair hair (HP:0002286)2.02057961
105Nephronophthisis (HP:0000090)2.01569002
106Muscle abnormality related to mitochondrial dysfunction (HP:0003800)2.00563181
107Preauricular pit (HP:0004467)1.97594880
108Periauricular skin pits (HP:0100277)1.97594880
109Abnormal respiratory motile cilium physiology (HP:0012261)1.97465879
110Dysmetric saccades (HP:0000641)1.96516081
111Abnormality of carpal bone ossification (HP:0006257)1.95948862
112Broad-based gait (HP:0002136)1.95914220
113Clumsiness (HP:0002312)1.95879865
114Mesomelia (HP:0003027)1.95839695
115Tarsal synostosis (HP:0008368)1.94859281
116Sparse lateral eyebrow (HP:0005338)1.93702152
117Dyschromatopsia (HP:0007641)1.91830530
118Abnormality of the nasal septum (HP:0000419)1.91578874
119Widely spaced teeth (HP:0000687)1.91149171
120Clubbing of toes (HP:0100760)1.90681842
121Renal Fanconi syndrome (HP:0001994)1.90591202
122Stomach cancer (HP:0012126)1.89669284
123Abnormality of the pubic bones (HP:0003172)1.88799754
124Nasolacrimal duct obstruction (HP:0000579)1.88363628
125Congenital hepatic fibrosis (HP:0002612)1.88213550
126Rectal prolapse (HP:0002035)1.88116965
127Absent rod-and cone-mediated responses on ERG (HP:0007688)1.88066748
128Abnormal ossification of hand bones (HP:0005921)1.87546006
129Shallow orbits (HP:0000586)1.87442079
130Aplasia of the musculature (HP:0100854)1.87364213
131Abnormal biliary tract morphology (HP:0012440)1.87246376
132Absent speech (HP:0001344)1.87032331
133Congenital primary aphakia (HP:0007707)1.86818974
134Alveolar cell carcinoma (HP:0006519)1.85242427
135Protruding tongue (HP:0010808)1.84969966
136Atonic seizures (HP:0010819)1.83606562
137Abnormality of ocular smooth pursuit (HP:0000617)1.83479770
138Follicular hyperkeratosis (HP:0007502)1.83403934
139Attenuation of retinal blood vessels (HP:0007843)1.82885269
140Absent septum pellucidum (HP:0001331)1.82478901
141Aplasia/Hypoplasia of the sacrum (HP:0008517)1.81910912
142Abnormality of the axillary hair (HP:0100134)1.81121853
143Abnormality of secondary sexual hair (HP:0009888)1.81121853
144Short chin (HP:0000331)1.80625321
145Gait imbalance (HP:0002141)1.80287778
146Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.80126983
147Aplasia/Hypoplasia of the lens (HP:0008063)1.79946423
148Broad palm (HP:0001169)1.79900746
149Abnormal hand bone ossification (HP:0010660)1.79213006
150Abnormality of dentin (HP:0010299)1.79144759
151Postaxial foot polydactyly (HP:0001830)1.79111466
152Aplasia/Hypoplasia of the tibia (HP:0005772)1.78690257
153Type 1 muscle fiber predominance (HP:0003803)1.77890370
154Keratoconus (HP:0000563)1.77420281
155Increased corneal curvature (HP:0100692)1.77420281
156Synostosis involving bones of the lower limbs (HP:0009138)1.77393949
157Synostosis involving bones of the feet (HP:0009140)1.77393949
158Generalized hypopigmentation of hair (HP:0011358)1.77303516
159Neoplasm of the heart (HP:0100544)1.77054891
160Thyroid-stimulating hormone excess (HP:0002925)1.76171102
161Keratitis (HP:0000491)1.74988512
162Skin pits (HP:0100276)1.74934839
163Abnormality of the acetabulum (HP:0003170)1.72990257
164Aplasia cutis congenita (HP:0001057)1.72328780
165Stomatitis (HP:0010280)1.71989991
166Abnormality of proline metabolism (HP:0010907)1.71944010
167Hydroxyprolinuria (HP:0003080)1.71944010
168Gingivitis (HP:0000230)1.71403219
169Abnormality of renal resorption (HP:0011038)1.71186466
170Abnormality of the phalanges of the hallux (HP:0010057)1.70828694
171Focal seizures (HP:0007359)1.70761456
172Morphological abnormality of the middle ear (HP:0008609)1.70222549
173Absence seizures (HP:0002121)1.69970931
174Recurrent lower respiratory tract infections (HP:0002783)1.69924449
175Basal ganglia calcification (HP:0002135)1.69783132
176Recurrent bacterial skin infections (HP:0005406)1.69753344
177Torticollis (HP:0000473)1.69070852
178Preaxial hand polydactyly (HP:0001177)1.68580225
179Prolonged QT interval (HP:0001657)1.68537155
180Abnormality of the septum pellucidum (HP:0007375)1.68106165
181Synostosis of carpal bones (HP:0005048)1.67798545
182Abnormality of the fovea (HP:0000493)1.66970993
183Spinal rigidity (HP:0003306)1.66614480
184Prominent supraorbital ridges (HP:0000336)1.64615715
185Lip pit (HP:0100267)1.64244670
186Hypoplasia of the iris (HP:0007676)1.63994115
187Encephalitis (HP:0002383)1.63784497
188Ectopic kidney (HP:0000086)1.63289395
189Short 1st metacarpal (HP:0010034)1.62864731
190Aplasia/Hypoplasia of the 1st metacarpal (HP:0010026)1.62864731

Predicted kinase interactions (KEA)

RankGene SetZ-score
1FRK5.41195111
2ZAK3.45970100
3CASK3.45780031
4TAF13.41605246
5NTRK13.34019642
6IRAK32.88553774
7TESK22.82721526
8NTRK22.77226799
9TXK2.73094306
10IRAK42.72409749
11MAP3K142.65324538
12STK162.33277920
13DDR22.27628997
14BMPR22.14621980
15DMPK2.05861912
16SIK32.03545696
17NUAK11.85768601
18MUSK1.78736465
19TNIK1.75947331
20BMPR1B1.74256083
21ACVR1B1.72685891
22PLK41.71846665
23PAK21.70965705
24RIPK11.69656839
25NTRK31.66637191
26PBK1.63237846
27MST41.62951204
28EIF2AK21.60407666
29PDGFRA1.60390695
30ADRBK21.59587878
31AKT31.58109992
32TIE11.54361367
33CLK11.52920075
34YES11.52270575
35MAP2K71.52187870
36BCR1.51613340
37MYLK1.50137109
38VRK11.49130645
39NEK61.47129487
40SRPK11.46745169
41INSRR1.45376097
42FGFR21.42061845
43ERBB31.39209496
44MKNK21.38150780
45PRKD21.36201571
46EIF2AK11.35738335
47PRPF4B1.35381739
48BLK1.33590405
49PIK3CA1.29354348
50GRK11.29021316
51KIT1.28043757
52IRAK21.26617411
53CDC42BPA1.26607604
54IRAK11.25173139
55STK381.23894330
56MAP3K121.23891667
57TLK11.22406621
58MAP3K71.16135362
59CAMK1D1.14814786
60TRPM71.14553476
61MKNK11.13626214
62CAMK1G1.13273260
63STK38L1.12152499
64PKN11.09870869
65MARK21.03709415
66PAK31.03461389
67STK111.03148314
68CDK31.02637747
69MAPKAPK30.99784659
70TEC0.98730769
71GRK70.98555581
72MAPK130.96451629
73FGFR30.95727012
74IKBKB0.94260136
75SIK20.94057574
76ICK0.89465503
77IKBKE0.88862552
78PINK10.88836602
79PLK20.85680075
80MAPKAPK50.85247476
81MAP2K60.84038383
82NLK0.83015468
83PRKCE0.82859993
84SGK20.82349502
85ROCK10.82242528
86MAP3K20.82005285
87STK390.81170492
88PRKD10.81032209
89CDK80.80067179
90STK240.79994047
91ZAP700.79795706
92CDK120.79702648
93TTN0.79080732
94RIPK40.78840659
95PTK20.77589753
96MAP2K10.75552258
97CAMK10.74281220
98SIK10.73865911
99PTK2B0.73262459
100MAPK150.72214588
101TYK20.70879849
102TNK20.68632203
103WNK40.66642944
104PDGFRB0.66580975
105MELK0.66548906
106PRKCH0.66235276
107OXSR10.65752282
108WNK10.65426109
109MAPK120.65038209
110SGK4940.61001959
111SGK2230.61001959
112LATS10.60577285
113LYN0.60549290
114NEK90.60516007
115MAP3K130.59377607
116MTOR0.58998103
117CHUK0.58526519
118PLK30.55497808
119PRKAA10.53571041
120SGK10.52055999
121LMTK20.50033119
122JAK30.49771352
123PIM20.49395378
124GSK3A0.49250981
125DYRK20.48547663
126MAPK70.45675405
127PRKCQ0.45204325
128WNK30.44487410
129TAOK30.43716702
130MARK10.43702287
131EIF2AK30.39783926
132EPHA40.39196539
133CAMK2B0.38636832
134STK30.38071040
135PIK3CG0.37992503
136CAMK2A0.37607532
137PRKCD0.37027241
138PRKAA20.36121714
139PRKCZ0.35625484
140RPS6KA30.35496725
141CSNK1A1L0.35108692
142JAK10.34306501
143BTK0.33198619
144TSSK60.33157048
145RPS6KA50.33004953
146NME20.31479896
147LCK0.31143472
148BRAF0.30539489
149ADRBK10.30221087
150PRKG10.29857862
151CAMK40.29116700
152RAF10.28374470
153SRC0.28302669
154CAMK2D0.27895194
155TTK0.27419060
156TGFBR20.27317447
157TAOK20.27143408
158SYK0.27125662
159MET0.26959464
160OBSCN0.26423980
161ATR0.26337372
162PRKACA0.26264331
163CAMK2G0.25916580
164RET0.25434281
165ABL10.25359053
166MAPK10.25300819
167CDK190.25084865
168KSR20.24611671

Predicted pathways (KEGG)

RankGene SetZ-score
1Graft-versus-host disease_Homo sapiens_hsa053323.08888055
2Cytosolic DNA-sensing pathway_Homo sapiens_hsa046232.78064092
3Allograft rejection_Homo sapiens_hsa053302.76847231
4Autoimmune thyroid disease_Homo sapiens_hsa053202.65158466
5ECM-receptor interaction_Homo sapiens_hsa045122.50986667
6Vascular smooth muscle contraction_Homo sapiens_hsa042702.30118987
7Intestinal immune network for IgA production_Homo sapiens_hsa046722.16520491
8Protein export_Homo sapiens_hsa030602.11137590
9Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005632.06926147
10RNA polymerase_Homo sapiens_hsa030202.04032940
11Fanconi anemia pathway_Homo sapiens_hsa034602.03933006
12Rheumatoid arthritis_Homo sapiens_hsa053231.94789395
13Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.93912024
14Focal adhesion_Homo sapiens_hsa045101.77813552
15Renin secretion_Homo sapiens_hsa049241.77397265
16NF-kappa B signaling pathway_Homo sapiens_hsa040641.77266730
17Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.76916541
18SNARE interactions in vesicular transport_Homo sapiens_hsa041301.76667190
19Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.73118731
20cGMP-PKG signaling pathway_Homo sapiens_hsa040221.72931978
21Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.72510077
22Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.71582047
23Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054101.70218286
24Dilated cardiomyopathy_Homo sapiens_hsa054141.64955079
25Protein digestion and absorption_Homo sapiens_hsa049741.63187979
26Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.62391026
27Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.59159558
28Salivary secretion_Homo sapiens_hsa049701.59119183
29Arachidonic acid metabolism_Homo sapiens_hsa005901.55631616
30Gastric acid secretion_Homo sapiens_hsa049711.54168022
31Oxytocin signaling pathway_Homo sapiens_hsa049211.53357042
32Dorso-ventral axis formation_Homo sapiens_hsa043201.51256225
33Insulin secretion_Homo sapiens_hsa049111.50234033
34Asthma_Homo sapiens_hsa053101.47532532
35Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.44051265
36Homologous recombination_Homo sapiens_hsa034401.42929181
37Type I diabetes mellitus_Homo sapiens_hsa049401.39135614
38Basal transcription factors_Homo sapiens_hsa030221.38380764
39Sphingolipid metabolism_Homo sapiens_hsa006001.36843685
40Primary immunodeficiency_Homo sapiens_hsa053401.36510717
41Primary bile acid biosynthesis_Homo sapiens_hsa001201.35501511
42Oxidative phosphorylation_Homo sapiens_hsa001901.29310868
43Complement and coagulation cascades_Homo sapiens_hsa046101.27885236
44Ether lipid metabolism_Homo sapiens_hsa005651.27057686
45Circadian entrainment_Homo sapiens_hsa047131.26711012
46Hematopoietic cell lineage_Homo sapiens_hsa046401.26619071
47Measles_Homo sapiens_hsa051621.24593291
48Aldosterone synthesis and secretion_Homo sapiens_hsa049251.22990577
49Taste transduction_Homo sapiens_hsa047421.21275479
50Nicotine addiction_Homo sapiens_hsa050331.19953899
51RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.18944298
52cAMP signaling pathway_Homo sapiens_hsa040241.17258789
53GABAergic synapse_Homo sapiens_hsa047271.15011173
54Proteasome_Homo sapiens_hsa030501.14321341
55Phototransduction_Homo sapiens_hsa047441.13442915
56Phosphatidylinositol signaling system_Homo sapiens_hsa040701.12689350
57Purine metabolism_Homo sapiens_hsa002301.12572150
58Toll-like receptor signaling pathway_Homo sapiens_hsa046201.12064333
59Cholinergic synapse_Homo sapiens_hsa047251.09957695
60Lysine degradation_Homo sapiens_hsa003101.07357367
61Long-term depression_Homo sapiens_hsa047301.06064866
62Estrogen signaling pathway_Homo sapiens_hsa049151.05948814
63Malaria_Homo sapiens_hsa051441.04194693
64Leishmaniasis_Homo sapiens_hsa051401.03543006
65Pyrimidine metabolism_Homo sapiens_hsa002401.03288521
66NOD-like receptor signaling pathway_Homo sapiens_hsa046211.02580271
67African trypanosomiasis_Homo sapiens_hsa051431.02301541
68Other glycan degradation_Homo sapiens_hsa005111.01630594
69Thyroid hormone synthesis_Homo sapiens_hsa049181.00291479
70Cell adhesion molecules (CAMs)_Homo sapiens_hsa045141.00176521
71Base excision repair_Homo sapiens_hsa034100.99999533
72Serotonergic synapse_Homo sapiens_hsa047260.98122491
73Phospholipase D signaling pathway_Homo sapiens_hsa040720.96818066
74Fatty acid biosynthesis_Homo sapiens_hsa000610.96338529
75Vitamin digestion and absorption_Homo sapiens_hsa049770.94650756
76Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.94314400
77Bile secretion_Homo sapiens_hsa049760.93447654
78Type II diabetes mellitus_Homo sapiens_hsa049300.92894699
79Herpes simplex infection_Homo sapiens_hsa051680.92561649
80DNA replication_Homo sapiens_hsa030300.90956267
81Amphetamine addiction_Homo sapiens_hsa050310.90651737
82Pancreatic secretion_Homo sapiens_hsa049720.90269699
83Morphine addiction_Homo sapiens_hsa050320.89892273
84Axon guidance_Homo sapiens_hsa043600.89404855
85Glioma_Homo sapiens_hsa052140.89070553
86Platelet activation_Homo sapiens_hsa046110.88996085
87Inositol phosphate metabolism_Homo sapiens_hsa005620.88928786
88Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.85450459
89Long-term potentiation_Homo sapiens_hsa047200.83947907
90Huntingtons disease_Homo sapiens_hsa050160.83753079
91Steroid biosynthesis_Homo sapiens_hsa001000.83511444
92Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.82126242
93Phagosome_Homo sapiens_hsa041450.81091083
94Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.80163538
95Hedgehog signaling pathway_Homo sapiens_hsa043400.79470170
96Cocaine addiction_Homo sapiens_hsa050300.78736229
97RNA degradation_Homo sapiens_hsa030180.76359808
98Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.76103529
99Parkinsons disease_Homo sapiens_hsa050120.75946016
100Linoleic acid metabolism_Homo sapiens_hsa005910.75864787
101Pertussis_Homo sapiens_hsa051330.75192687
102Regulation of actin cytoskeleton_Homo sapiens_hsa048100.75125038
103Chemical carcinogenesis_Homo sapiens_hsa052040.75004698
104alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.74664685
105Proteoglycans in cancer_Homo sapiens_hsa052050.74471360
106Steroid hormone biosynthesis_Homo sapiens_hsa001400.74144129
107Alzheimers disease_Homo sapiens_hsa050100.74004927
108Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.73816800
109Influenza A_Homo sapiens_hsa051640.73458049
110Glucagon signaling pathway_Homo sapiens_hsa049220.73277833
111GnRH signaling pathway_Homo sapiens_hsa049120.72917709
112TGF-beta signaling pathway_Homo sapiens_hsa043500.72307865
113Mineral absorption_Homo sapiens_hsa049780.71148117
114Choline metabolism in cancer_Homo sapiens_hsa052310.70965807
115Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.70781737
116Amoebiasis_Homo sapiens_hsa051460.70267554
117Dopaminergic synapse_Homo sapiens_hsa047280.69865696
118Collecting duct acid secretion_Homo sapiens_hsa049660.69277295
119Regulation of autophagy_Homo sapiens_hsa041400.69245132
120Tryptophan metabolism_Homo sapiens_hsa003800.68878950
121PI3K-Akt signaling pathway_Homo sapiens_hsa041510.68556102
122Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.67706911
123Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.67036279
124Retinol metabolism_Homo sapiens_hsa008300.66933015
125Nucleotide excision repair_Homo sapiens_hsa034200.65319595
126Non-homologous end-joining_Homo sapiens_hsa034500.65082049
127Gap junction_Homo sapiens_hsa045400.63622746
128Melanoma_Homo sapiens_hsa052180.62634180
129Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.62553329
130Fatty acid elongation_Homo sapiens_hsa000620.62107101
131Melanogenesis_Homo sapiens_hsa049160.59772392
132Jak-STAT signaling pathway_Homo sapiens_hsa046300.58761159
133Ras signaling pathway_Homo sapiens_hsa040140.58556841
134TNF signaling pathway_Homo sapiens_hsa046680.57593420
135Pentose and glucuronate interconversions_Homo sapiens_hsa000400.55815635
136Ribosome_Homo sapiens_hsa030100.55456838
137Ovarian steroidogenesis_Homo sapiens_hsa049130.54680458
138Chemokine signaling pathway_Homo sapiens_hsa040620.54196416
139Renin-angiotensin system_Homo sapiens_hsa046140.53537531
140Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.52693971
141Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.52251471
142ErbB signaling pathway_Homo sapiens_hsa040120.52060692
143AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.51570086
144Circadian rhythm_Homo sapiens_hsa047100.51329970
145Small cell lung cancer_Homo sapiens_hsa052220.51237996
146Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.50970030
147Insulin resistance_Homo sapiens_hsa049310.50305399
148Glutamatergic synapse_Homo sapiens_hsa047240.50093080
149Adherens junction_Homo sapiens_hsa045200.49865573
150Maturity onset diabetes of the young_Homo sapiens_hsa049500.49326469
151Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.49275414
152Calcium signaling pathway_Homo sapiens_hsa040200.48854032
153Tuberculosis_Homo sapiens_hsa051520.48841431
154Olfactory transduction_Homo sapiens_hsa047400.48430171
155Legionellosis_Homo sapiens_hsa051340.48335077
156Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.48304432
157Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.48283675
158MicroRNAs in cancer_Homo sapiens_hsa052060.47908024
159Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.47701242
160Glycerolipid metabolism_Homo sapiens_hsa005610.47458138
161Vitamin B6 metabolism_Homo sapiens_hsa007500.45700095
162Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.44878197
163Transcriptional misregulation in cancer_Homo sapiens_hsa052020.44318306
164Staphylococcus aureus infection_Homo sapiens_hsa051500.42260835
165Glycosaminoglycan degradation_Homo sapiens_hsa005310.41218066
166Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.40833153
167Mismatch repair_Homo sapiens_hsa034300.38929334
168Salmonella infection_Homo sapiens_hsa051320.37715843
169Hepatitis C_Homo sapiens_hsa051600.37471458
170Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.37010336
171Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.37000919
172ABC transporters_Homo sapiens_hsa020100.36423693
173Histidine metabolism_Homo sapiens_hsa003400.36276864
174Vibrio cholerae infection_Homo sapiens_hsa051100.34383313
175Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.33122305
176Spliceosome_Homo sapiens_hsa030400.31850702

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