SLC38A4

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: SLC38A4 is found predominantly in liver and transports both cationic and neutral amino acids. The transport of cationic amino acids by SLC38A4 is Na(+) and pH independent, while the transport of neutral amino acids is Na(+) and pH dependent (Hatanaka et al., 2001 [PubMed 11342143]). NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1omega-hydroxylase P450 pathway (GO:0097267)7.91867888
2exogenous drug catabolic process (GO:0042738)7.83133948
3L-phenylalanine catabolic process (GO:0006559)7.65122254
4erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)7.65122254
5L-phenylalanine metabolic process (GO:0006558)7.33162210
6erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)7.33162210
7aromatic amino acid family catabolic process (GO:0009074)6.78864292
8triglyceride-rich lipoprotein particle remodeling (GO:0034370)6.19974671
9indole-containing compound catabolic process (GO:0042436)6.01536821
10indolalkylamine catabolic process (GO:0046218)6.01536821
11tryptophan catabolic process (GO:0006569)6.01536821
12kynurenine metabolic process (GO:0070189)5.95552149
13bile acid biosynthetic process (GO:0006699)5.83378048
14glyoxylate metabolic process (GO:0046487)5.72167451
15tryptophan metabolic process (GO:0006568)5.72056133
16negative regulation of fibrinolysis (GO:0051918)5.61912502
17urea cycle (GO:0000050)5.61026144
18urea metabolic process (GO:0019627)5.61026144
19alpha-linolenic acid metabolic process (GO:0036109)5.54418525
20sulfur amino acid catabolic process (GO:0000098)5.49709570
21high-density lipoprotein particle remodeling (GO:0034375)5.47840660
22ethanol metabolic process (GO:0006067)5.44359072
23regulation of fibrinolysis (GO:0051917)5.38241810
24peptidyl-glutamic acid carboxylation (GO:0017187)5.38175222
25protein carboxylation (GO:0018214)5.38175222
26cysteine metabolic process (GO:0006534)5.30167495
27regulation of protein activation cascade (GO:2000257)5.28240180
28complement activation, alternative pathway (GO:0006957)5.24255798
29oxidative demethylation (GO:0070989)5.21515222
30phenylpropanoid metabolic process (GO:0009698)5.20997827
31serine family amino acid catabolic process (GO:0009071)5.20102744
32nitrogen cycle metabolic process (GO:0071941)5.13602960
33bile acid metabolic process (GO:0008206)5.04910531
34negative regulation of protein activation cascade (GO:2000258)4.96353721
35aromatic amino acid family metabolic process (GO:0009072)4.94558743
36regulation of complement activation (GO:0030449)4.93214794
37homocysteine metabolic process (GO:0050667)4.87350423
38tyrosine metabolic process (GO:0006570)4.84211111
39reverse cholesterol transport (GO:0043691)4.78619005
40S-adenosylmethionine metabolic process (GO:0046500)4.75204626
41fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)4.69705372
42regulation of cholesterol esterification (GO:0010872)4.69488689
43macromolecular complex remodeling (GO:0034367)4.66470745
44plasma lipoprotein particle remodeling (GO:0034369)4.66470745
45protein-lipid complex remodeling (GO:0034368)4.66470745
46alpha-amino acid catabolic process (GO:1901606)4.65744235
47glycine metabolic process (GO:0006544)4.63758815
48triglyceride homeostasis (GO:0070328)4.62641474
49acylglycerol homeostasis (GO:0055090)4.62641474
50lysine metabolic process (GO:0006553)4.62636489
51lysine catabolic process (GO:0006554)4.62636489
52regulation of triglyceride catabolic process (GO:0010896)4.61626732
53coenzyme catabolic process (GO:0009109)4.58357942
54amino-acid betaine metabolic process (GO:0006577)4.54526559
55negative regulation of sterol transport (GO:0032372)4.49297424
56negative regulation of cholesterol transport (GO:0032375)4.49297424
57imidazole-containing compound metabolic process (GO:0052803)4.47681426
58phospholipid efflux (GO:0033700)4.43421187
59bile acid and bile salt transport (GO:0015721)4.40577535
60negative regulation of complement activation (GO:0045916)4.39868063
61plasma lipoprotein particle clearance (GO:0034381)4.31885009
62cellular amino acid catabolic process (GO:0009063)4.31214277
63indolalkylamine metabolic process (GO:0006586)4.31119277
64cellular modified amino acid catabolic process (GO:0042219)4.29489115
65serine family amino acid metabolic process (GO:0009069)4.25850546
66regulation of plasminogen activation (GO:0010755)4.25283206
67cellular ketone body metabolic process (GO:0046950)4.17778256
68cellular glucuronidation (GO:0052695)4.17214458
69glutamate metabolic process (GO:0006536)4.14833859
70cholesterol efflux (GO:0033344)4.09963089
71amine catabolic process (GO:0009310)4.09394569
72cellular biogenic amine catabolic process (GO:0042402)4.09394569
73serine family amino acid biosynthetic process (GO:0009070)4.09026090
74benzene-containing compound metabolic process (GO:0042537)3.99302916
75opsonization (GO:0008228)3.94461998
76dicarboxylic acid biosynthetic process (GO:0043650)3.92195447
77fibrinolysis (GO:0042730)3.90682445
78regulation of humoral immune response (GO:0002920)3.89933540
79plasma lipoprotein particle assembly (GO:0034377)3.89114890
80arginine metabolic process (GO:0006525)3.88143536
81ethanol oxidation (GO:0006069)3.86347534
82aldehyde catabolic process (GO:0046185)3.84730378
83drug catabolic process (GO:0042737)3.82870691
84low-density lipoprotein particle remodeling (GO:0034374)3.82562531
85acute-phase response (GO:0006953)3.81999434
86negative regulation of blood coagulation (GO:0030195)3.81973957
87negative regulation of hemostasis (GO:1900047)3.81973957
88regulation of cholesterol homeostasis (GO:2000188)3.80051830
89cofactor catabolic process (GO:0051187)3.79162593
90blood coagulation, intrinsic pathway (GO:0007597)3.77523235
91heme transport (GO:0015886)3.75078880
92phospholipid homeostasis (GO:0055091)3.74822132
93regulation of bile acid biosynthetic process (GO:0070857)3.74002074
94cholesterol homeostasis (GO:0042632)3.72587906
95carboxylic acid catabolic process (GO:0046395)3.72158880
96organic acid catabolic process (GO:0016054)3.72158880
97xenobiotic catabolic process (GO:0042178)3.71995335
98sterol homeostasis (GO:0055092)3.66736023
99complement activation, classical pathway (GO:0006958)3.65732984
100glucuronate metabolic process (GO:0019585)3.65242583
101uronic acid metabolic process (GO:0006063)3.65242583
102positive regulation of lipoprotein lipase activity (GO:0051006)3.62934171
103positive regulation of triglyceride lipase activity (GO:0061365)3.62934171
104positive regulation of lipid catabolic process (GO:0050996)3.61477760
105cytolysis (GO:0019835)3.61254455
106very-low-density lipoprotein particle assembly (GO:0034379)3.60838215
107complement activation (GO:0006956)3.60073799
108protein activation cascade (GO:0072376)3.59955471
109ketone body metabolic process (GO:1902224)3.59548808
110intestinal cholesterol absorption (GO:0030299)3.59299077
111drug metabolic process (GO:0017144)3.57191294
112acetyl-CoA metabolic process (GO:0006084)3.57101487
113negative regulation of lipase activity (GO:0060192)3.56369967
114epoxygenase P450 pathway (GO:0019373)3.56099857
115lipoprotein metabolic process (GO:0042157)3.52898601
116negative regulation of coagulation (GO:0050819)3.52183726
117negative regulation of wound healing (GO:0061045)3.50751221
118plasma lipoprotein particle organization (GO:0071827)3.50687868
119positive regulation of heterotypic cell-cell adhesion (GO:0034116)3.47467394
120flavonoid metabolic process (GO:0009812)3.43398387
121killing of cells in other organism involved in symbiotic interaction (GO:0051883)3.39111887
122disruption of cells of other organism involved in symbiotic interaction (GO:0051818)3.39111887
123alkaloid metabolic process (GO:0009820)3.36931031
124negative regulation of humoral immune response (GO:0002921)3.32898239
125primary alcohol metabolic process (GO:0034308)3.30490763
126L-alpha-amino acid transmembrane transport (GO:1902475)3.28761580
127xenobiotic metabolic process (GO:0006805)3.26535136
128positive regulation of blood coagulation (GO:0030194)3.13904144
129positive regulation of hemostasis (GO:1900048)3.13904144
130polyketide metabolic process (GO:0030638)3.05242525
131doxorubicin metabolic process (GO:0044598)3.05242525
132daunorubicin metabolic process (GO:0044597)3.05242525

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1* RXR_22158963_ChIP-Seq_LIVER_Mouse8.31086985
2PPARA_22158963_ChIP-Seq_LIVER_Mouse7.19688632
3EGR1_23403033_ChIP-Seq_LIVER_Mouse6.76256351
4* LXR_22158963_ChIP-Seq_LIVER_Mouse6.45110971
5FOXO1_23066095_ChIP-Seq_LIVER_Mouse5.22288551
6CEBPA_23403033_ChIP-Seq_LIVER_Mouse5.10009078
7PPARG_19300518_ChIP-PET_3T3-L1_Mouse4.59933863
8NR1I2_20693526_ChIP-Seq_LIVER_Mouse4.08805351
9CEBPB_23403033_ChIP-Seq_LIVER_Mouse4.03827689
10POU3F2_20337985_ChIP-ChIP_501MEL_Human2.29187899
11GBX2_23144817_ChIP-Seq_PC3_Human2.06813417
12HNF4A_19761587_ChIP-ChIP_CACO-2_Human2.06188123
13TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse2.03011237
14E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.01848251
15ESR1_17901129_ChIP-ChIP_LIVER_Mouse11.7948468
16TCF7L2_21901280_ChIP-Seq_H4IIE_Rat1.97554991
17GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.95124750
18CLOCK_20551151_ChIP-Seq_293T_Human1.76896449
19PIAS1_25552417_ChIP-Seq_VCAP_Human1.75050996
20GATA1_22025678_ChIP-Seq_K562_Human1.71243142
21GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.67719886
22ZFP57_27257070_Chip-Seq_ESCs_Mouse1.62803381
23STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.57978512
24BCAT_22108803_ChIP-Seq_LS180_Human1.57902120
25EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.56104373
26* FOXA2_19822575_ChIP-Seq_HepG2_Human1.55885129
27IGF1R_20145208_ChIP-Seq_DFB_Human1.53043921
28NFE2_27457419_Chip-Seq_LIVER_Mouse1.50321889
29* HNF4A_19822575_ChIP-Seq_HepG2_Human1.43937473
30SUZ12_27294783_Chip-Seq_NPCs_Mouse1.42506062
31EZH2_27294783_Chip-Seq_NPCs_Mouse1.40958728
32ESR1_15608294_ChIP-ChIP_MCF-7_Human1.39234004
33* AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.36967537
34FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.36059273
35HTT_18923047_ChIP-ChIP_STHdh_Human1.35878505
36FLI1_27457419_Chip-Seq_LIVER_Mouse1.33819907
37ER_23166858_ChIP-Seq_MCF-7_Human1.30934816
38RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.29194467
39CDX2_19796622_ChIP-Seq_MESCs_Mouse1.25711598
40EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.23084106
41RXRA_24833708_ChIP-Seq_LIVER_Mouse1.21680569
42EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse1.19021700
43CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.18559995
44CDX2_22108803_ChIP-Seq_LS180_Human1.18016314
45PCGF2_27294783_Chip-Seq_NPCs_Mouse1.16745858
46* SMAD4_21799915_ChIP-Seq_A2780_Human1.15170065
47NANOG_18555785_Chip-Seq_ESCs_Mouse1.14647460
48MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.13511010
49PHF8_20622853_ChIP-Seq_HELA_Human1.13379217
50TAF15_26573619_Chip-Seq_HEK293_Human1.13356804
51SOX2_18555785_Chip-Seq_ESCs_Mouse1.13079438
52PCGF2_27294783_Chip-Seq_ESCs_Mouse1.12969992
53SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.12933376
54P53_22387025_ChIP-Seq_ESCs_Mouse1.12112320
55CRX_20693478_ChIP-Seq_RETINA_Mouse1.11327145
56STAT3_18555785_Chip-Seq_ESCs_Mouse1.11027829
57STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.10913701
58SOX2_27498859_Chip-Seq_STOMACH_Mouse1.10299029
59OCT4_18555785_Chip-Seq_ESCs_Mouse1.10152036
60P300_19829295_ChIP-Seq_ESCs_Human1.09570866
61STAT3_1855785_ChIP-Seq_MESCs_Mouse1.07136526
62FUS_26573619_Chip-Seq_HEK293_Human1.06845947
63HNFA_21074721_ChIP-Seq_CACO-2_Human1.06655609
64POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.06587783
65FOXA1_25329375_ChIP-Seq_VCAP_Human1.06492479
66FOXA1_27270436_Chip-Seq_PROSTATE_Human1.06492479
67E2F1_18555785_Chip-Seq_ESCs_Mouse1.05320545
68AR_25329375_ChIP-Seq_VCAP_Human1.05198840
69SUZ12_18555785_Chip-Seq_ESCs_Mouse1.04466431
70ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.03881846
71NANOG_19829295_ChIP-Seq_ESCs_Human1.03833442
72SOX2_19829295_ChIP-Seq_ESCs_Human1.03833442
73* CBP_21632823_ChIP-Seq_H3396_Human1.03596780
74* STAT3_23295773_ChIP-Seq_U87_Human1.03457275
75NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.02608689
76SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse1.02580128
77NMYC_18555785_Chip-Seq_ESCs_Mouse1.02358176
78CMYC_18555785_Chip-Seq_ESCs_Mouse1.00612337
79OCT4_21477851_ChIP-Seq_ESCs_Mouse1.00042996
80TCF4_23295773_ChIP-Seq_U87_Human0.99856963
81CTCF_18555785_Chip-Seq_ESCs_Mouse0.99714311
82P300_18555785_Chip-Seq_ESCs_Mouse0.99512937
83SMAD1_18555785_Chip-Seq_ESCs_Mouse0.99434610
84TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse0.98527743
85CDX2_21074721_ChIP-Seq_CACO-2_Mouse0.98360086
86FOXA1_21572438_ChIP-Seq_LNCaP_Human0.98291863
87* NFYA_21822215_ChIP-Seq_K562_Human0.98285748
88ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.97718429
89FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.97712223
90* CTBP2_25329375_ChIP-Seq_LNCAP_Human0.97618991
91TCF4_22108803_ChIP-Seq_LS180_Human0.97198389
92RUNX1_27457419_Chip-Seq_LIVER_Mouse0.97119220
93GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse0.97057995
94SMAD3_21741376_ChIP-Seq_EPCs_Human0.96724086
95IRF4_20064451_ChIP-Seq_CD4+T_Mouse0.96347389
96CBP_20019798_ChIP-Seq_JUKART_Human0.96347389
97CEBPD_23245923_ChIP-Seq_MEFs_Mouse0.96042600
98TP53_18474530_ChIP-ChIP_U2OS_Human0.94521216
99PU1_27457419_Chip-Seq_LIVER_Mouse0.93964552
100SALL4_18804426_ChIP-ChIP_XEN_Mouse0.93919465
101GATA4_25053715_ChIP-Seq_YYC3_Human0.93151746
102* CTBP1_25329375_ChIP-Seq_LNCAP_Human0.92751363
103SMAD2/3_21741376_ChIP-Seq_EPCs_Human0.92493248
104KLF4_18555785_Chip-Seq_ESCs_Mouse0.91861223
105KLF5_18264089_ChIP-ChIP_MESCs_Mouse0.91511039
106KLF4_18264089_ChIP-ChIP_MESCs_Mouse0.91511039
107KLF2_18264089_ChIP-ChIP_MESCs_Mouse0.91511039
108KLF5_20875108_ChIP-Seq_MESCs_Mouse0.91366007
109ZFX_18555785_Chip-Seq_ESCs_Mouse0.91210909
110PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse0.85852318
111THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse0.85021059
112RARA_24833708_ChIP-Seq_LIVER_Mouse0.83488992
113ZNF263_19887448_ChIP-Seq_K562_Human0.81979586
114SREBP1_19666523_ChIP-Seq_LIVER_Mouse0.80972528
115ESRRB_18555785_ChIP-Seq_MESCs_Mouse0.78225626
116ZNF652_21678463_ChIP-ChIP_ZR75-1_Human0.77103954
117NACC1_18358816_ChIP-ChIP_MESCs_Mouse0.76964339
118SREBP2_21459322_ChIP-Seq_LIVER_Mouse0.76591681
119RARB_24833708_ChIP-Seq_LIVER_Mouse0.74753618
120RARG_19884340_ChIP-ChIP_MEFs_Mouse0.72852351
121KAP1_22055183_ChIP-Seq_ESCs_Mouse0.72737336
122AUTS2_25519132_ChIP-Seq_293T-REX_Human0.72225873
123FOXA1_26743006_Chip-Seq_LNCaP-abl_Human0.70806468
124AR_21915096_ChIP-Seq_LNCaP-1F5_Human0.69578168
125* TCF3_18692474_ChIP-Seq_MEFs_Mouse0.69445464
126TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse0.69134503
127ESR2_21235772_ChIP-Seq_MCF-7_Human0.65586432
128PDX1_19855005_ChIP-ChIP_MIN6_Mouse0.64909915
129CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.64565209
130ESR1_21235772_ChIP-Seq_MCF-7_Human0.62290845
131* GATA6_25053715_ChIP-Seq_YYC3_Human0.61723404
132FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human0.61146234
133BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.60851842
134PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse0.60018723
135NANOG_16518401_ChIP-PET_MESCs_Mouse0.59655679
136SOX2_18358816_ChIP-ChIP_MESCs_Mouse0.58994242
137POU5F1_16518401_ChIP-PET_MESCs_Mouse0.57409330
138* TCF3_18692474_ChIP-Seq_MESCs_Mouse0.56104912
139FOXO3_23340844_ChIP-Seq_DLD1_Human0.56007795
140IRF1_19129219_ChIP-ChIP_H3396_Human0.55098481
141ESET_19884257_ChIP-Seq_ESCs_Mouse0.54693561
142BMI1_19503595_ChIP-Seq_MEFsC_Mouse0.53200573
143FOXA1_25552417_ChIP-Seq_VCAP_Human0.53043449
144OCT4_18692474_ChIP-Seq_MEFs_Mouse0.52372844
145* SOX2_18692474_ChIP-Seq_MEFs_Mouse0.51390099
146* GATA3_20176728_ChIP-ChIP_TSCs_Mouse0.51311539
147NANOG_18700969_ChIP-ChIP_MESCs_Mouse0.50561809
148GATA3_24758297_ChIP-Seq_MCF-7_Human0.50394650
149CDX2_20551321_ChIP-Seq_CACO-2_Human0.48475645
150AR_20517297_ChIP-Seq_VCAP_Human0.48284228
151FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human0.47851505
152NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human0.47745926
153CEBPB_22108803_ChIP-Seq_LS180_Human0.47503691
154AR_21909140_ChIP-Seq_LNCAP_Human0.46279055
155IRF1_21803131_ChIP-Seq_MONOCYTES_Human0.45604662
156RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human0.44968907
157* LXR_22292898_ChIP-Seq_THP-1_Human0.44804977
158SPI1_26923725_Chip-Seq_HPCs_Mouse0.42089726
159* PPARG_20887899_ChIP-Seq_3T3-L1_Mouse0.41206057
160NRF2_20460467_ChIP-Seq_MEFs_Mouse0.40660632
161NFE2L2_20460467_ChIP-Seq_MEFs_Mouse0.40660632
162RAD21_21589869_ChIP-Seq_MESCs_Mouse0.39702794
163PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.38994595
164RACK7_27058665_Chip-Seq_MCF-7_Human0.38770352
165STAT3_19079543_ChIP-ChIP_MESCs_Mouse0.38394510
166NR4A2_19515692_ChIP-ChIP_MN9D_Mouse0.38360861
167* PPARD_23208498_ChIP-Seq_MDA-MB-231_Human0.37787904
168GATA1_19941826_ChIP-Seq_K562_Human0.37601250
169* TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.37514726
170MYC_19915707_ChIP-ChIP_AK7_Human0.36948803
171ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human0.36850974
172* SOX2_18692474_ChIP-Seq_MESCs_Mouse0.36489366
173Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse0.36479888
174SMAD1_18555785_ChIP-Seq_MESCs_Mouse0.35732249
175ERG_20517297_ChIP-Seq_VCAP_Human0.35189730
176PRDM5_23873026_ChIP-Seq_MEFs_Mouse0.35131017

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002139_abnormal_hepatobiliary_system8.17649251
2MP0005360_urolithiasis7.25710287
3MP0005085_abnormal_gallbladder_physiolo6.41693763
4MP0005365_abnormal_bile_salt6.17505176
5MP0008875_abnormal_xenobiotic_pharmacok4.96392961
6MP0003806_abnormal_nucleotide_metabolis4.54168343
7MP0003252_abnormal_bile_duct4.00963924
8MP0010329_abnormal_lipoprotein_level3.45725138
9MP0009840_abnormal_foam_cell3.16193327
10MP0003195_calcinosis3.08206009
11MP0005083_abnormal_biliary_tract3.05182076
12MP0005332_abnormal_amino_acid2.66059526
13MP0001666_abnormal_nutrient_absorption2.53588051
14MP0009780_abnormal_chondrocyte_physiolo2.41691136
15MP0005379_endocrine/exocrine_gland_phen2.20959762
16MP0000609_abnormal_liver_physiology2.17203569
17MP0004019_abnormal_vitamin_homeostasis2.04066122
18MP0002118_abnormal_lipid_homeostasis2.01129916
19MP0003868_abnormal_feces_composition1.97638968
20MP0003191_abnormal_cellular_cholesterol1.96916380
21MP0002138_abnormal_hepatobiliary_system1.89407177
22MP0002909_abnormal_adrenal_gland1.86266657
23MP0005319_abnormal_enzyme/_coenzyme1.82381062
24MP0000013_abnormal_adipose_tissue1.67334823
25MP0003705_abnormal_hypodermis_morpholog1.66800892
26MP0009697_abnormal_copulation1.59597324
27MP0001764_abnormal_homeostasis1.53712999
28MP0003011_delayed_dark_adaptation1.47592783
29MP0005645_abnormal_hypothalamus_physiol1.39026905
30MP0005584_abnormal_enzyme/coenzyme_acti1.37184368
31MP0009643_abnormal_urine_homeostasis1.26593281
32MP0002254_reproductive_system_inflammat1.25988618
33MP0000598_abnormal_liver_morphology1.25072575
34MP0003186_abnormal_redox_activity1.23760008
35MP0005451_abnormal_body_composition1.21171046
36MP0005646_abnormal_pituitary_gland1.07767093
37MP0002163_abnormal_gland_morphology1.05182407
38MP0004264_abnormal_extraembryonic_tissu1.04795755
39MP0010368_abnormal_lymphatic_system1.02906417
40MP0003879_abnormal_hair_cell0.98999694
41MP0005647_abnormal_sex_gland0.95029082
42MP0003656_abnormal_erythrocyte_physiolo0.94967761
43MP0002078_abnormal_glucose_homeostasis0.93956297
44MP0005220_abnormal_exocrine_pancreas0.93084951
45MP0009763_increased_sensitivity_to0.92226256
46MP0005670_abnormal_white_adipose0.90076788
47MP0010386_abnormal_urinary_bladder0.89511265
48MP0008872_abnormal_physiological_respon0.86732799
49MP0009053_abnormal_anal_canal0.86521299
50MP0006036_abnormal_mitochondrial_physio0.86338349
51MP0005408_hypopigmentation0.85978875
52MP0005636_abnormal_mineral_homeostasis0.83785673
53MP0009642_abnormal_blood_homeostasis0.82131144
54MP0005266_abnormal_metabolism0.81475553
55MP0005376_homeostasis/metabolism_phenot0.80713418
56MP0003122_maternal_imprinting0.80314478
57MP0000003_abnormal_adipose_tissue0.79423261
58MP0006072_abnormal_retinal_apoptosis0.72998915
59MP0000604_amyloidosis0.72460459
60MP0009764_decreased_sensitivity_to0.72144325
61MP0005551_abnormal_eye_electrophysiolog0.71930015
62MP0001661_extended_life_span0.71662376
63MP0008469_abnormal_protein_level0.70152838
64MP0000639_abnormal_adrenal_gland0.69870945
65MP0009765_abnormal_xenobiotic_induced0.68031844
66MP0006035_abnormal_mitochondrial_morpho0.66971509
67MP0009672_abnormal_birth_weight0.65097169
68MP0002971_abnormal_brown_adipose0.64700284
69MP0005334_abnormal_fat_pad0.64597904
70MP0005248_abnormal_Harderian_gland0.64476351
71MP0001756_abnormal_urination0.64071978
72MP0002295_abnormal_pulmonary_circulatio0.63950461
73MP0003283_abnormal_digestive_organ0.63242827
74MP0002837_dystrophic_cardiac_calcinosis0.62612095
75MP0005084_abnormal_gallbladder_morpholo0.62225175
76MP0002876_abnormal_thyroid_physiology0.56633605
77MP0003787_abnormal_imprinting0.55210084
78MP0005448_abnormal_energy_balance0.54567058
79MP0003633_abnormal_nervous_system0.54201196
80MP0004130_abnormal_muscle_cell0.54076953
81MP0002928_abnormal_bile_duct0.52772711
82MP0005535_abnormal_body_temperature0.52435645
83MP0002938_white_spotting0.52335137
84MP0002090_abnormal_vision0.51116493
85MP0005395_other_phenotype0.50742064
86MP0001944_abnormal_pancreas_morphology0.50220875
87MP0003890_abnormal_embryonic-extraembry0.48424127
88MP0004043_abnormal_pH_regulation0.47863789
89MP0003718_maternal_effect0.47471198
90MP0002132_abnormal_respiratory_system0.47061043
91MP0001984_abnormal_olfaction0.45681260
92MP0005058_abnormal_lysosome_morphology0.45398416
93MP0003172_abnormal_lysosome_physiology0.44932897
94MP0003953_abnormal_hormone_level0.44631952
95MP0000372_irregular_coat_pigmentation0.44089769
96MP0005452_abnormal_adipose_tissue0.42261157
97MP0005666_abnormal_adipose_tissue0.41699181
98MP0002269_muscular_atrophy0.41074293
99MP0002970_abnormal_white_adipose0.40846805
100MP0004782_abnormal_surfactant_physiolog0.40794197
101MP0001765_abnormal_ion_homeostasis0.40016334
102MP0004142_abnormal_muscle_tone0.39656143
103MP0001243_abnormal_dermal_layer0.39573284
104MP0004270_analgesia0.39327755
105MP0008877_abnormal_DNA_methylation0.38381372
106MP0008873_increased_physiological_sensi0.37959975
107MP0002136_abnormal_kidney_physiology0.37521923
108MP0003638_abnormal_response/metabolism_0.35932740
109MP0001986_abnormal_taste_sensitivity0.35611452
110MP0009046_muscle_twitch0.35054099
111MP0002069_abnormal_eating/drinking_beha0.34469960
112MP0005187_abnormal_penis_morphology0.33966490
113MP0002168_other_aberrant_phenotype0.33811773
114MP0010234_abnormal_vibrissa_follicle0.33376850
115MP0002796_impaired_skin_barrier0.33321534
116MP0005023_abnormal_wound_healing0.32802098
117MP0003690_abnormal_glial_cell0.32505200
118MP0002693_abnormal_pancreas_physiology0.29093307
119MP0009115_abnormal_fat_cell0.28201228
120MP0000579_abnormal_nail_morphology0.27758209
121MP0000230_abnormal_systemic_arterial0.27707282
122MP0009384_cardiac_valve_regurgitation0.27590788
123MP0003329_amyloid_beta_deposits0.27108237
124MP0002060_abnormal_skin_morphology0.25527164
125MP0000249_abnormal_blood_vessel0.24786644
126MP0001915_intracranial_hemorrhage0.22739735
127MP0004883_abnormal_blood_vessel0.22679851
128MP0000427_abnormal_hair_cycle0.22406475
129MP0002135_abnormal_kidney_morphology0.21690467
130MP0001881_abnormal_mammary_gland0.21430505
131MP0008874_decreased_physiological_sensi0.21235051
132MP0003119_abnormal_digestive_system0.21095216
133MP0009703_decreased_birth_body0.19553271

Predicted human phenotypes

RankGene SetZ-score
1Intrahepatic cholestasis (HP:0001406)7.49984986
2Abnormality of aromatic amino acid family metabolism (HP:0004338)7.48790042
3Deep venous thrombosis (HP:0002625)7.22222116
4Abnormality of monocarboxylic acid metabolism (HP:0010996)6.82774609
5Hypobetalipoproteinemia (HP:0003563)6.42153482
6Prolonged partial thromboplastin time (HP:0003645)6.34977314
7Xanthomatosis (HP:0000991)6.23360589
8Hyperlipoproteinemia (HP:0010980)5.24231181
9Complement deficiency (HP:0004431)5.10744516
10Hypolipoproteinemia (HP:0010981)4.83425716
11Hypoglycemic coma (HP:0001325)4.55987843
12Epidermoid cyst (HP:0200040)4.52332452
13Hyperammonemia (HP:0001987)4.52001127
14Joint hemorrhage (HP:0005261)4.49802919
15Abnormality of the common coagulation pathway (HP:0010990)4.49723918
16Hyperglycinemia (HP:0002154)4.39022366
17Ketosis (HP:0001946)4.35741184
18Abnormality of the level of lipoprotein cholesterol (HP:0010979)4.35451208
19Abnormality of methionine metabolism (HP:0010901)4.28954223
20Abnormality of the intrinsic pathway (HP:0010989)4.28938406
21Abnormality of sulfur amino acid metabolism (HP:0004339)4.26278905
22Hypoalphalipoproteinemia (HP:0003233)4.22786311
23Fat malabsorption (HP:0002630)4.11042527
24Abnormality of aspartate family amino acid metabolism (HP:0010899)4.03554942
25Hyperglycinuria (HP:0003108)3.97156013
26Abnormality of glutamine family amino acid metabolism (HP:0010902)3.97096969
27Abnormality of pyrimidine metabolism (HP:0004353)3.87344030
28Abnormality of serine family amino acid metabolism (HP:0010894)3.86968577
29Abnormality of glycine metabolism (HP:0010895)3.86968577
30Conjugated hyperbilirubinemia (HP:0002908)3.82912104
31Abnormality of complement system (HP:0005339)3.73227099
32Hypochromic microcytic anemia (HP:0004840)3.58366294
33Hypercholesterolemia (HP:0003124)3.55069411
34Ketoacidosis (HP:0001993)3.36706710
35Hyperinsulinemic hypoglycemia (HP:0000825)3.32784759
36Hyperbilirubinemia (HP:0002904)3.31568494
37Hypoglycemic seizures (HP:0002173)3.29771008
38Abnormality of long-chain fatty-acid metabolism (HP:0010964)3.22996938
39Abnormality of vitamin metabolism (HP:0100508)3.20247262
40Skin nodule (HP:0200036)3.15999346
41Abnormality of fatty-acid metabolism (HP:0004359)3.10782206
42Abnormality of nucleobase metabolism (HP:0010932)3.08154097
43Hepatocellular carcinoma (HP:0001402)3.07985801
44Delayed CNS myelination (HP:0002188)2.99767603
45Nephritis (HP:0000123)2.98861188
46Steatorrhea (HP:0002570)2.96114625
47Abnormality of serum amino acid levels (HP:0003112)2.95531665
48Hypothermia (HP:0002045)2.86685180
49Glycosuria (HP:0003076)2.81094618
50Abnormality of urine glucose concentration (HP:0011016)2.81094618
51Myocardial infarction (HP:0001658)2.71544055
52Abnormality of purine metabolism (HP:0004352)2.68559131
53Metabolic acidosis (HP:0001942)2.67132355
54Spontaneous abortion (HP:0005268)2.66466670
55Gout (HP:0001997)2.60310563
56Spastic diplegia (HP:0001264)2.55392043
57Fair hair (HP:0002286)2.52960595
58Dicarboxylic aciduria (HP:0003215)2.51604497
59Abnormality of dicarboxylic acid metabolism (HP:0010995)2.51604497
60Lethargy (HP:0001254)2.50270857
61Irritability (HP:0000737)2.50202086
62Proximal tubulopathy (HP:0000114)2.48804316
63Abnormal gallbladder morphology (HP:0012437)2.47193459
64Hyperglycemia (HP:0003074)2.46668553
65Late onset (HP:0003584)2.44618395
66Enlarged kidneys (HP:0000105)2.38514393
67Malnutrition (HP:0004395)2.38423998
68Acanthocytosis (HP:0001927)2.36214876
69Cholelithiasis (HP:0001081)2.32390395
70Systemic lupus erythematosus (HP:0002725)2.31517304
71Osteomalacia (HP:0002749)2.31253333
72Symptomatic seizures (HP:0011145)2.30931537
73Vascular calcification (HP:0004934)2.30791722
74Arthropathy (HP:0003040)2.28401313
75Abnormal cartilage morphology (HP:0002763)2.27227745
76Esophageal varix (HP:0002040)2.26207474
77Hyperphosphaturia (HP:0003109)2.24770698
78Cerebral edema (HP:0002181)2.21180047
79Abnormality of the pancreatic islet cells (HP:0006476)2.19574302
80Abnormality of endocrine pancreas physiology (HP:0012093)2.19574302
81Mitral stenosis (HP:0001718)2.19463259
82Neonatal onset (HP:0003623)2.18201495
83Neonatal hypoglycemia (HP:0001998)2.17076885
84Cholecystitis (HP:0001082)2.16290426
85Abnormal gallbladder physiology (HP:0012438)2.16290426
86Generalized aminoaciduria (HP:0002909)2.15850405
87Glomerulonephritis (HP:0000099)2.15296531
88Abnormality of vitamin B metabolism (HP:0004340)2.14196584
89Pancreatic islet-cell hyperplasia (HP:0004510)2.13889933
90Pancreatitis (HP:0001733)2.04715943
91Increased CSF protein (HP:0002922)2.04165276
92Cardiovascular calcification (HP:0011915)2.03678209
93Brushfield spots (HP:0001088)2.03614621
94Abnormal enzyme/coenzyme activity (HP:0012379)2.00341696
95Rickets (HP:0002748)1.98475259
96Abnormality of the gallbladder (HP:0005264)1.96024914
97Large for gestational age (HP:0001520)1.95235913
98Hepatoblastoma (HP:0002884)1.95040708
99Menorrhagia (HP:0000132)1.94927502
100Vomiting (HP:0002013)1.94161425
101Amyloidosis (HP:0011034)1.91090079
102Sensorimotor neuropathy (HP:0007141)1.90295680
103Abnormality of transition element cation homeostasis (HP:0011030)1.88684648
104Gingival bleeding (HP:0000225)1.88472515
105Recurrent gram-negative bacterial infections (HP:0005420)1.86014618
106Thrombophlebitis (HP:0004418)1.85871002
107Methylmalonic acidemia (HP:0002912)1.85822294
108Generalized hypopigmentation of hair (HP:0011358)1.84643473
109Abnormality of iron homeostasis (HP:0011031)1.82887073
110Hypophosphatemic rickets (HP:0004912)1.82559525
111Blue irides (HP:0000635)1.82169341
112Intestinal atresia (HP:0011100)1.81622362
113Opisthotonus (HP:0002179)1.81124232
114Abnormality of proline metabolism (HP:0010907)1.79975823
115Hydroxyprolinuria (HP:0003080)1.79975823
116Elevated alkaline phosphatase (HP:0003155)1.79005238
117Poikilocytosis (HP:0004447)1.78082435
118Hemorrhage of the eye (HP:0011885)1.77866193
119Abnormality of alkaline phosphatase activity (HP:0004379)1.77354677
120Reticulocytosis (HP:0001923)1.75259407
121Renal cortical cysts (HP:0000803)1.74668155
122Abnormal urine phosphate concentration (HP:0012599)1.69857448
123Insulin-resistant diabetes mellitus (HP:0000831)1.67803158
124Bile duct proliferation (HP:0001408)1.65090588
125Abnormal biliary tract physiology (HP:0012439)1.65090588
126Double outlet right ventricle (HP:0001719)1.63619209
127Congenital malformation of the right heart (HP:0011723)1.63619209
128Urinary glycosaminoglycan excretion (HP:0003541)1.63102345
129Mucopolysacchariduria (HP:0008155)1.63102345
130Abnormality of mucopolysaccharide metabolism (HP:0011020)1.62826741
131Abnormality of polysaccharide metabolism (HP:0011012)1.62826741
132Abnormality of glycosaminoglycan metabolism (HP:0004371)1.62826741
133Joint swelling (HP:0001386)1.56017950

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BCKDK6.29885976
2ERN14.73933680
3SIK14.02580646
4FGFR43.86348102
5INSRR3.72762262
6TAOK33.07739160
7PHKG22.81469957
8PHKG12.81469957
9FLT32.69696062
10ERBB42.62433879
11PKN22.58693539
12LATS12.32125805
13NTRK32.14624631
14MST42.14289715
15CDK122.03617349
16MAP2K41.98368755
17MAP4K21.91327183
18TRPM71.88428176
19NLK1.84624935
20TRIB31.84324467
21PIK3CG1.69792318
22ADRBK21.64119835
23STK161.61911742
24PTK61.59208182
25MAP3K101.55138003
26FRK1.55126373
27MAPK111.54098880
28STK38L1.52448345
29MST1R1.49372545
30MET1.48548163
31PRKCE1.48163896
32EPHA21.36969701
33MAP3K41.35372805
34TNK21.30810316
35MAPK151.27655855
36CAMK2D1.26539308
37GRK61.21351125
38UHMK11.21058156
39MAP3K121.18131864
40KDR1.16030077
41MAP3K31.13693578
42AKT31.12458245
43WNK41.09099589
44NEK91.06725272
45ABL21.05339101
46PTK21.04316738
47ERBB21.02200250
48MYLK1.01569980
49TYK20.96922339
50JAK20.96885067
51MAP3K70.95685065
52MAP3K90.94172432
53FGFR20.93523879
54PRKAA20.93261379
55MAP2K30.93093676
56YES10.92135401
57BMPR1B0.90542314
58PDGFRA0.88362201
59MTOR0.86355782
60MAPK70.85908336
61PASK0.84438416
62EIF2AK30.83744018
63CAMKK20.82062973
64ERBB30.81424675
65EPHA30.80174313
66NEK10.79263100
67CDK60.79204068
68MUSK0.79056163
69PRKG10.76127884
70PIK3CA0.75581672
71STK40.75469992
72HIPK20.74217294
73GSK3A0.72938743
74PRKAA10.72872224
75TGFBR20.71135506
76FGFR30.71012258
77CSNK1G30.70744039
78DYRK1B0.69866135
79LATS20.68443729
80RIPK10.68318407
81PRKACG0.67843554
82GRK10.67122016
83PRKD30.67108173
84PRKACA0.65868739
85TTK0.64217465
86DAPK20.63163168
87CSF1R0.62333895
88PTK2B0.60385568
89CSNK1G20.57966293
90CSK0.57843378
91CDK40.57413354
92CASK0.56995242
93PLK20.55303596
94CSNK1D0.55209154
95PRKCZ0.54874044
96CAMK1D0.54711132
97STK390.54313283
98PINK10.53826245
99MAP2K70.53172255
100PRKACB0.52939954
101MAPK40.52447542
102MKNK20.52377652
103CSNK1A10.51439660
104TIE10.51092504
105IGF1R0.50644243
106IRAK10.49959444
107OXSR10.49864455
108MAP2K60.49779364
109STK30.49754159
110JAK10.49116614
111MAP3K20.48443939
112STK110.47806358
113TNIK0.47773337
114PRKCA0.47716394
115PRKCI0.47499311
116PAK30.45841646
117CAMK1G0.45792481
118LIMK10.43946847
119MAPK120.40967998
120CAMK40.40101540
121PRKD20.40056267
122ICK0.38907233
123RET0.38773701
124STK380.38001997
125SGK20.37995696
126ACVR1B0.37276415
127STK240.37251726
128MAP3K110.37201596
129FGFR10.36854494
130SGK10.36205269
131ADRBK10.36060124
132MAP2K20.35647615
133PRKCB0.35433782
134ZAK0.35324501
135CAMK2G0.35189182
136MAPK130.35076678
137MAP3K50.34931377
138MAP2K10.34928885
139FER0.34576187
140GRK50.34304823
141IRAK30.33761183
142EPHB10.33619268
143MAP3K10.33277303
144OBSCN0.31665614
145PRKG20.30384813
146TAOK20.30330058
147SGK30.29913963
148CSNK1E0.29093065
149EGFR0.29038129
150NTRK10.29009226
151AKT20.27052505
152TBK10.26783185
153CSNK1G10.24782558
154WNK30.21604370
155MAP3K80.21155164
156PRKCG0.18917474
157MAPK10.18345049
158BRSK20.18253805

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary bile acid biosynthesis_Homo sapiens_hsa001204.41218956
2Nitrogen metabolism_Homo sapiens_hsa009103.64125258
3Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004003.41229521
4Ascorbate and aldarate metabolism_Homo sapiens_hsa000533.33347730
5Arginine biosynthesis_Homo sapiens_hsa002203.02250114
6Tryptophan metabolism_Homo sapiens_hsa003802.77156672
7Complement and coagulation cascades_Homo sapiens_hsa046102.70675487
8Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006302.61112728
9Glycine, serine and threonine metabolism_Homo sapiens_hsa002602.57175024
10Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010402.53374731
11Fatty acid degradation_Homo sapiens_hsa000712.43221546
12Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.41182643
13Pentose and glucuronate interconversions_Homo sapiens_hsa000402.26858295
14Butanoate metabolism_Homo sapiens_hsa006502.09327385
15Drug metabolism - cytochrome P450_Homo sapiens_hsa009822.04666141
16Peroxisome_Homo sapiens_hsa041461.98321693
17Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.91497532
18Chemical carcinogenesis_Homo sapiens_hsa052041.89352457
19Selenocompound metabolism_Homo sapiens_hsa004501.85735460
20Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.85653405
21Steroid hormone biosynthesis_Homo sapiens_hsa001401.84929628
22Histidine metabolism_Homo sapiens_hsa003401.84625317
23Drug metabolism - other enzymes_Homo sapiens_hsa009831.83166392
24Propanoate metabolism_Homo sapiens_hsa006401.83047649
25PPAR signaling pathway_Homo sapiens_hsa033201.77832338
26Fatty acid metabolism_Homo sapiens_hsa012121.72684655
27Maturity onset diabetes of the young_Homo sapiens_hsa049501.70763796
28Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.66693589
29Caffeine metabolism_Homo sapiens_hsa002321.65506374
30Retinol metabolism_Homo sapiens_hsa008301.64411432
31beta-Alanine metabolism_Homo sapiens_hsa004101.62159766
32Phenylalanine metabolism_Homo sapiens_hsa003601.59725490
33Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.56165297
34Staphylococcus aureus infection_Homo sapiens_hsa051501.55804258
352-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.54316829
36Bile secretion_Homo sapiens_hsa049761.45877385
37Sulfur metabolism_Homo sapiens_hsa009201.45186187
38Tyrosine metabolism_Homo sapiens_hsa003501.44803903
39Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.35543075
40Starch and sucrose metabolism_Homo sapiens_hsa005001.34042427
41Cysteine and methionine metabolism_Homo sapiens_hsa002701.33988873
42Folate biosynthesis_Homo sapiens_hsa007901.33882103
43Pyruvate metabolism_Homo sapiens_hsa006201.31885053
44Biosynthesis of amino acids_Homo sapiens_hsa012301.29108964
45Fat digestion and absorption_Homo sapiens_hsa049751.23067312
46Fatty acid elongation_Homo sapiens_hsa000621.21258879
47ABC transporters_Homo sapiens_hsa020101.21101240
48Carbon metabolism_Homo sapiens_hsa012001.18388616
49Steroid biosynthesis_Homo sapiens_hsa001001.09630066
50One carbon pool by folate_Homo sapiens_hsa006701.07719843
51Vitamin B6 metabolism_Homo sapiens_hsa007501.04363228
52Arginine and proline metabolism_Homo sapiens_hsa003300.97263443
53Lysine degradation_Homo sapiens_hsa003100.91924616
54Cyanoamino acid metabolism_Homo sapiens_hsa004600.89277312
55Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.89259934
56Sulfur relay system_Homo sapiens_hsa041220.84808555
57Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.81306174
58Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.79588720
59Vitamin digestion and absorption_Homo sapiens_hsa049770.79050313
60Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.72304465
61Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.69801692
62Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.64646732
63Glycerolipid metabolism_Homo sapiens_hsa005610.64112678
64Glutathione metabolism_Homo sapiens_hsa004800.60625400
65Pentose phosphate pathway_Homo sapiens_hsa000300.59042200
66Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.50117246
67Galactose metabolism_Homo sapiens_hsa000520.48832818
68Insulin secretion_Homo sapiens_hsa049110.48761018
69Metabolic pathways_Homo sapiens_hsa011000.46503993
70Fructose and mannose metabolism_Homo sapiens_hsa000510.42773722
71Prion diseases_Homo sapiens_hsa050200.39522176
72Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.38390429
73Fatty acid biosynthesis_Homo sapiens_hsa000610.37257465
74alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.35710253
75Linoleic acid metabolism_Homo sapiens_hsa005910.34827847
76Insulin resistance_Homo sapiens_hsa049310.33503283
77Circadian rhythm_Homo sapiens_hsa047100.28694094
78Other glycan degradation_Homo sapiens_hsa005110.26482428
79Sphingolipid metabolism_Homo sapiens_hsa006000.25762530
80Serotonergic synapse_Homo sapiens_hsa047260.21361473
81Glucagon signaling pathway_Homo sapiens_hsa049220.20698218
82Mineral absorption_Homo sapiens_hsa049780.20566514
83Adipocytokine signaling pathway_Homo sapiens_hsa049200.20065097
84Oxidative phosphorylation_Homo sapiens_hsa001900.17743554
85Ether lipid metabolism_Homo sapiens_hsa005650.17646537
86Pertussis_Homo sapiens_hsa051330.16753124
87Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.16720193
88Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.15936949
89Glycerophospholipid metabolism_Homo sapiens_hsa005640.14311327
90Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.13078479
91Collecting duct acid secretion_Homo sapiens_hsa049660.10592829
92AMPK signaling pathway_Homo sapiens_hsa041520.09708626
93Renin secretion_Homo sapiens_hsa049240.00519660
94Longevity regulating pathway - mammal_Homo sapiens_hsa04211-0.1838874
95Type II diabetes mellitus_Homo sapiens_hsa04930-0.1810434
96Carbohydrate digestion and absorption_Homo sapiens_hsa04973-0.1810160
97Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604-0.1707256
98Thyroid hormone synthesis_Homo sapiens_hsa04918-0.1641219
99Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa04550-0.1612742
100Renin-angiotensin system_Homo sapiens_hsa04614-0.1612001
101Bladder cancer_Homo sapiens_hsa05219-0.1495213
102Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932-0.1367031
103Protein export_Homo sapiens_hsa03060-0.0953231
104Systemic lupus erythematosus_Homo sapiens_hsa05322-0.0888167
105Arachidonic acid metabolism_Homo sapiens_hsa00590-0.0849608
106Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa00534-0.0802275
107Regulation of autophagy_Homo sapiens_hsa04140-0.0637070
108Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970-0.0598870
109Insulin signaling pathway_Homo sapiens_hsa04910-0.0547301
110Glycosaminoglycan degradation_Homo sapiens_hsa00531-0.0545138
111Central carbon metabolism in cancer_Homo sapiens_hsa05230-0.0501260
112Ovarian steroidogenesis_Homo sapiens_hsa04913-0.0491173
113Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603-0.0361873
114Vascular smooth muscle contraction_Homo sapiens_hsa04270-0.0190544

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