SLC38A5

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene is a system N sodium-coupled amino acid transporter. The encoded protein transports glutamine, asparagine, histidine, serine, alanine, and glycine across the cell membrane, but does not transport charged amino acids, imino acids, or N-alkylated amino acids. Alternative splicing results in multiple transcript variants, but the full-length nature of some of these variants has not been determined. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1positive regulation of insulin secretion involved in cellular response to glucose stimulus (GO:003579.61901334
2COPI coating of Golgi vesicle (GO:0048205)8.50300958
3Golgi transport vesicle coating (GO:0048200)8.50300958
4negative regulation of execution phase of apoptosis (GO:1900118)7.37058456
5DNA strand renaturation (GO:0000733)7.30002941
6positive regulation of insulin secretion (GO:0032024)6.27032518
7positive regulation of vesicle fusion (GO:0031340)6.18529163
8artery smooth muscle contraction (GO:0014824)5.98016634
9negative regulation of JUN kinase activity (GO:0043508)5.97929510
10positive regulation of peptidyl-threonine phosphorylation (GO:0010800)5.84152732
11maintenance of protein localization in endoplasmic reticulum (GO:0035437)5.76569707
12L-alpha-amino acid transmembrane transport (GO:1902475)5.74298406
13positive regulation of amino acid transport (GO:0051957)5.74188016
14positive regulation of histone H3-K4 methylation (GO:0051571)5.53689268
15regulation of cardioblast proliferation (GO:0003264)5.47206810
16regulation of secondary heart field cardioblast proliferation (GO:0003266)5.47206810
17protein retention in ER lumen (GO:0006621)5.45636274
18tonic smooth muscle contraction (GO:0014820)5.27559937
19COPII vesicle coating (GO:0048208)5.10244381
20endocrine pancreas development (GO:0031018)5.10000694
21exocrine pancreas development (GO:0031017)5.04324152
22retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)4.99276574
23regulation of respiratory burst (GO:0060263)4.97083375
24positive regulation of peptide hormone secretion (GO:0090277)4.94057121
25positive regulation of gluconeogenesis (GO:0045722)4.89101052
26regulation of insulin secretion involved in cellular response to glucose stimulus (GO:0061178)4.82333134
27regulation of mitochondrial translation (GO:0070129)4.81329332
28positive regulation of peptide secretion (GO:0002793)4.75599461
29beta-amyloid metabolic process (GO:0050435)4.45478257
30positive regulation of vasculogenesis (GO:2001214)4.42944980
31protoporphyrinogen IX biosynthetic process (GO:0006782)4.40551545
32peptide hormone processing (GO:0016486)4.39486302
33positive regulation of calcium ion-dependent exocytosis (GO:0045956)4.35915131
34oxygen transport (GO:0015671)4.27440735
35protein autoprocessing (GO:0016540)4.25145074
36digestion (GO:0007586)4.20449404
37negative regulation of digestive system process (GO:0060457)4.18826280
38neuron fate specification (GO:0048665)4.11912383
39genitalia morphogenesis (GO:0035112)4.11491641
40DNA unwinding involved in DNA replication (GO:0006268)4.08896296
41glandular epithelial cell differentiation (GO:0002067)4.04498641
42astrocyte differentiation (GO:0048708)3.98238039
43GDP-mannose metabolic process (GO:0019673)3.95348109
44pharyngeal system development (GO:0060037)3.90600352
45negative regulation of intracellular estrogen receptor signaling pathway (GO:0033147)3.88754992
46signal peptide processing (GO:0006465)3.85966410
47endocardial cushion morphogenesis (GO:0003203)3.80413219
48nuclear pore complex assembly (GO:0051292)3.80129444
49positive regulation of hormone secretion (GO:0046887)3.77123509
50gas transport (GO:0015669)3.76569451
51sequestering of metal ion (GO:0051238)3.75711761
52response to dietary excess (GO:0002021)3.75654694
53positive regulation of calcium ion import (GO:0090280)3.74799681
54regulation of insulin secretion (GO:0050796)3.69910202
55embryonic retina morphogenesis in camera-type eye (GO:0060059)3.69806627
56erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)3.68490267
57L-phenylalanine catabolic process (GO:0006559)3.68490267
58vesicle coating (GO:0006901)3.65560063
59positive regulation of granulocyte macrophage colony-stimulating factor production (GO:0032725)3.64767148
60negative regulation of erythrocyte differentiation (GO:0045647)3.62762383
61macroautophagy (GO:0016236)3.62378834
62GMP metabolic process (GO:0046037)3.61851662
63positive regulation of gamma-delta T cell activation (GO:0046645)3.57313250
64epithelial cell fate commitment (GO:0072148)3.57174576
65regulation of calcium ion-dependent exocytosis (GO:0017158)3.54991899
66erythrocyte maturation (GO:0043249)3.53448872
67response to misfolded protein (GO:0051788)3.53428765
68proline biosynthetic process (GO:0006561)3.50134934
69positive regulation of B cell differentiation (GO:0045579)3.45888287
70regulation of cell-cell adhesion mediated by cadherin (GO:2000047)3.45238072
71vascular smooth muscle contraction (GO:0014829)3.40594522
72regulation of translational fidelity (GO:0006450)3.40175786
73ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway (GO:0043163.36932821
74regulation of peptide hormone secretion (GO:0090276)3.33947766
75DNA replication initiation (GO:0006270)3.33763332
76pteridine-containing compound biosynthetic process (GO:0042559)3.31969625
77secondary heart field specification (GO:0003139)3.27706038
78heart field specification (GO:0003128)3.27706038
79DNA strand elongation involved in DNA replication (GO:0006271)3.27177458
80regulation of peptide secretion (GO:0002791)3.26633776
81cellular response to glucagon stimulus (GO:0071377)3.23177988
82antigen processing and presentation of endogenous peptide antigen (GO:0002483)3.23173837
83heme biosynthetic process (GO:0006783)3.22729765
84intestinal cholesterol absorption (GO:0030299)3.21964917
85positive regulation of receptor biosynthetic process (GO:0010870)3.21511917
86positive regulation of interleukin-2 biosynthetic process (GO:0045086)3.21385291
87porphyrin-containing compound biosynthetic process (GO:0006779)3.20371859
88antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)3.19188384
89pancreas development (GO:0031016)3.18150011
90cardiac right ventricle morphogenesis (GO:0003215)3.17462963
91DNA strand elongation (GO:0022616)3.15398393
92mucosal-associated lymphoid tissue development (GO:0048537)3.14293128
93Peyers patch development (GO:0048541)3.14293128
94nuclear pore organization (GO:0006999)3.11101360
95regulation of extracellular matrix disassembly (GO:0010715)3.10957680
96amyloid precursor protein catabolic process (GO:0042987)3.07971883
973-UTR-mediated mRNA stabilization (GO:0070935)3.07712470
98peptidyl-arginine omega-N-methylation (GO:0035247)3.05826443
99hemoglobin metabolic process (GO:0020027)3.05511699
100modulation by virus of host process (GO:0019054)3.05163475
101insulin secretion (GO:0030073)3.05077428
102folic acid-containing compound biosynthetic process (GO:0009396)3.04717409
103cellular hyperosmotic response (GO:0071474)3.03673114
104regulation of granulocyte macrophage colony-stimulating factor production (GO:0032645)3.03640403
105signal transduction involved in regulation of gene expression (GO:0023019)3.01458492
106erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)3.00419864
107L-phenylalanine metabolic process (GO:0006558)3.00419864
108protoporphyrinogen IX metabolic process (GO:0046501)2.99993877
109deoxyribonucleoside monophosphate metabolic process (GO:0009162)2.98238264
110regulation of peptidyl-threonine phosphorylation (GO:0010799)2.97784510
111toxin metabolic process (GO:0009404)2.97306207
112regulation of type I interferon-mediated signaling pathway (GO:0060338)2.97064237
113DNA topological change (GO:0006265)2.96884583
114tooth mineralization (GO:0034505)2.96739729
115auditory receptor cell differentiation (GO:0042491)2.96416985
116peptide hormone secretion (GO:0030072)2.96069192
117glandular epithelial cell development (GO:0002068)2.95521294
118regulation of protein homodimerization activity (GO:0043496)2.93747254
119phasic smooth muscle contraction (GO:0014821)2.93401855
120pore complex assembly (GO:0046931)2.93244344
121mitotic chromosome condensation (GO:0007076)2.92844323
122modulation by symbiont of host cellular process (GO:0044068)2.92712690
123antigen processing and presentation of endogenous antigen (GO:0019883)2.92500281
124cellular response to type I interferon (GO:0071357)2.91824152
125type I interferon signaling pathway (GO:0060337)2.91824152
126regulation of histone H3-K4 methylation (GO:0051569)2.91426420
127segment specification (GO:0007379)2.90247406
128regulation of hormone secretion (GO:0046883)2.89579080
129deoxyribose phosphate biosynthetic process (GO:0046385)2.89519484
1302-deoxyribonucleotide biosynthetic process (GO:0009265)2.89519484
131response to type I interferon (GO:0034340)2.87655234
132peptide secretion (GO:0002790)2.87205378
133nucleoside diphosphate catabolic process (GO:0009134)2.86283814
134pentose-phosphate shunt (GO:0006098)2.81569793
135regulation of vesicle fusion (GO:0031338)2.80100588
136regulation of vasculogenesis (GO:2001212)2.79338466
137mitochondrial calcium ion transport (GO:0006851)2.77095176
138cellular response to interleukin-4 (GO:0071353)2.76597496
139T cell migration (GO:0072678)2.74268314
140mitotic nuclear envelope disassembly (GO:0007077)2.72455541
141formation of translation preinitiation complex (GO:0001731)2.72213415
142positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)2.71642552
143telomere maintenance via semi-conservative replication (GO:0032201)2.70568540
144erythrocyte development (GO:0048821)2.70254409
145protein export from nucleus (GO:0006611)2.67491371
146positive regulation of granulocyte differentiation (GO:0030854)2.65075251
147regulation of translational termination (GO:0006449)2.64637156
148IMP biosynthetic process (GO:0006188)2.61445320
149heme metabolic process (GO:0042168)2.61276442
150nuclear envelope disassembly (GO:0051081)2.60906640
151membrane disassembly (GO:0030397)2.60906640
152regulation of response to osmotic stress (GO:0047484)2.60526564
153porphyrin-containing compound metabolic process (GO:0006778)2.59912578
154tetrapyrrole biosynthetic process (GO:0033014)2.59578345
155megakaryocyte development (GO:0035855)2.58483728
156positive regulation of type I interferon-mediated signaling pathway (GO:0060340)2.56695942
157cellular response to virus (GO:0098586)2.56448216
158pinocytosis (GO:0006907)2.55170557
159regulation of B cell differentiation (GO:0045577)2.54049236
160spliceosomal tri-snRNP complex assembly (GO:0000244)2.51879374
161thymic T cell selection (GO:0045061)2.51653794
162response to interleukin-4 (GO:0070670)2.50557827
163negative regulation of mRNA splicing, via spliceosome (GO:0048025)2.49939220
164regulation of histone H3-K27 methylation (GO:0061085)2.45047286
165response to interleukin-15 (GO:0070672)2.43678908
166response to peptidoglycan (GO:0032494)2.42802285
167negative thymic T cell selection (GO:0045060)2.42024669
168regulation of interleukin-2 biosynthetic process (GO:0045076)2.41920638
169deoxyribonucleotide biosynthetic process (GO:0009263)2.41613570
170chaperone mediated protein folding requiring cofactor (GO:0051085)2.41398558
171NADPH regeneration (GO:0006740)2.40287243
172NIK/NF-kappaB signaling (GO:0038061)2.38380112
173positive regulation by symbiont of host defense response (GO:0052509)2.38257301
174modulation by symbiont of host defense response (GO:0052031)2.38257301
175modulation by organism of immune response of other organism involved in symbiotic interaction (GO:002.38257301
176modulation by organism of defense response of other organism involved in symbiotic interaction (GO:02.38257301
177positive regulation by organism of defense response of other organism involved in symbiotic interact2.38257301
178modulation by symbiont of host immune response (GO:0052553)2.38257301
179peptidyl-arginine methylation (GO:0018216)2.37568059
180peptidyl-arginine N-methylation (GO:0035246)2.37568059
181negative T cell selection (GO:0043383)2.36621519
182negative regulation of phagocytosis (GO:0050765)2.35976004
183CD4-positive or CD8-positive, alpha-beta T cell lineage commitment (GO:0043369)2.35942053
184B cell receptor signaling pathway (GO:0050853)2.35846504
185nucleobase-containing small molecule interconversion (GO:0015949)2.34007568
186IMP metabolic process (GO:0046040)2.32139494
187ribosome biogenesis (GO:0042254)2.30253919
188regulation of gamma-delta T cell differentiation (GO:0045586)2.29809041
189histone arginine methylation (GO:0034969)2.27408256
190DNA duplex unwinding (GO:0032508)2.27246627
191folic acid metabolic process (GO:0046655)2.26619434
192regulation of RNA export from nucleus (GO:0046831)2.26228404

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse7.16971548
2E2F7_22180533_ChIP-Seq_HELA_Human6.36225715
3PDX1_19855005_ChIP-ChIP_MIN6_Mouse4.66750122
4HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse3.92052030
5GATA1_22025678_ChIP-Seq_K562_Human3.47937387
6MYC_22102868_ChIP-Seq_BL_Human3.22810269
7GABP_17652178_ChIP-ChIP_JURKAT_Human3.13543918
8DMRT1_21621532_ChIP-ChIP_FETAL_Ovary3.10526896
9ZNF652_21678463_ChIP-ChIP_ZR75-1_Human2.82994421
10TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.74663961
11IKZF1_21737484_ChIP-ChIP_HCT116_Human2.55592947
12VDR_21846776_ChIP-Seq_THP-1_Human2.55510424
13EGR1_19374776_ChIP-ChIP_THP-1_Human2.49291186
14PRDM5_23873026_ChIP-Seq_MEFs_Mouse2.37659113
15RBPJ_22232070_ChIP-Seq_NCS_Mouse2.34999384
16CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human2.33557322
17HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.29124541
18KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.28691553
19TP63_17297297_ChIP-ChIP_HaCaT_Human2.25699047
20JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.24568220
21EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.24170818
22POU5F1_18700969_ChIP-ChIP_MESCs_Mouse2.22995428
23FOXM1_23109430_ChIP-Seq_U2OS_Human2.16908732
24VDR_22108803_ChIP-Seq_LS180_Human2.10565290
25ESR1_17901129_ChIP-ChIP_LIVER_Mouse2.09163416
26NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.96938530
27CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.96016820
28OLIG2_26023283_ChIP-Seq_AINV15_Mouse1.93862827
29MYC_19079543_ChIP-ChIP_MESCs_Mouse1.89207408
30MAF_26560356_Chip-Seq_TH1_Human1.88775212
31NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.88061525
32CREB1_15753290_ChIP-ChIP_HEK293T_Human1.87127677
33ELK1_19687146_ChIP-ChIP_HELA_Human1.80473126
34PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.79526040
35MYC_19030024_ChIP-ChIP_MESCs_Mouse1.79010755
36ZFX_18555785_ChIP-Seq_MESCs_Mouse1.76257700
37PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.75890467
38SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.74409508
39KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.73443087
40CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.71519932
41ELK3_25401928_ChIP-Seq_HUVEC_Human1.70445681
42MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.70218558
43E2F4_17652178_ChIP-ChIP_JURKAT_Human1.69467098
44MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.66742484
45SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.65770867
46STAT4_19710469_ChIP-ChIP_TH1__Mouse1.63739521
47IRF8_22096565_ChIP-ChIP_GC-B_Human1.63505975
48ETS1_20019798_ChIP-Seq_JURKAT_Human1.63434026
49LXR_22292898_ChIP-Seq_THP-1_Human1.63115868
50THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.61213388
51EST1_17652178_ChIP-ChIP_JURKAT_Human1.59636362
52UTX_26944678_Chip-Seq_JUKART_Human1.58826963
53CLOCK_20551151_ChIP-Seq_293T_Human1.58192510
54CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.57655405
55FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.57558653
56GABP_19822575_ChIP-Seq_HepG2_Human1.57388386
57* NCOR1_26117541_ChIP-Seq_K562_Human1.55649265
58* TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.54604265
59E2F1_18555785_ChIP-Seq_MESCs_Mouse1.54202100
60CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse1.53943238
61BP1_19119308_ChIP-ChIP_Hs578T_Human1.53634483
62TCF7_22412390_ChIP-Seq_EML_Mouse1.52104903
63* E2F1_17053090_ChIP-ChIP_MCF-7_Human1.51990880
64LXR_22158963_ChIP-Seq_LIVER_Mouse1.49689439
65PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.49537113
66TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.47945601
67* MAF_26560356_Chip-Seq_TH2_Human1.47254385
68SCL_19346495_ChIP-Seq_HPC-7_Human1.47003441
69VDR_24763502_ChIP-Seq_THP-1_Human1.46650508
70FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human1.45804050
71RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.45687192
72ZNF263_19887448_ChIP-Seq_K562_Human1.44863514
73SOX2_27498859_Chip-Seq_STOMACH_Mouse1.42433500
74CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.40654817
75NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.40586616
76FOXP2_23625967_ChIP-Seq_PFSK-1_AND_SK-N-MC_Human1.40259743
77SOX17_20123909_ChIP-Seq_XEN_Mouse1.39898307
78ERG_20887958_ChIP-Seq_HPC-7_Mouse1.39718339
79DNAJC2_21179169_ChIP-ChIP_NT2_Human1.38287119
80ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.37728306
81* GATA1_22383799_ChIP-Seq_G1ME_Mouse1.37664306
82MYB_21317192_ChIP-Seq_ERMYB_Mouse1.37599470
83BRD4_27068464_Chip-Seq_AML-cells_Mouse1.36648206
84MYB_26560356_Chip-Seq_TH1_Human1.36027182
85RUNX1_22412390_ChIP-Seq_EML_Mouse1.35752506
86SRF_21415370_ChIP-Seq_HL-1_Mouse1.34883664
87SPI1_23547873_ChIP-Seq_NB4_Human1.32071934
88MYB_26560356_Chip-Seq_TH2_Human1.32021661
89E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.30985092
90XRN2_22483619_ChIP-Seq_HELA_Human1.30881623
91PPARD_23208498_ChIP-Seq_MDA-MB-231_Human1.30616158
92GATA4_25053715_ChIP-Seq_YYC3_Human1.29588275
93FOXA1_25552417_ChIP-Seq_VCAP_Human1.28884657
94CHD1_26751641_Chip-Seq_LNCaP_Human1.28673723
95CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.28567123
96DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.28084698
97CIITA_25753668_ChIP-Seq_RAJI_Human1.27882496
98GATA1_19941826_ChIP-Seq_K562_Human1.26991257
99SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.26934259
100HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.25662098
101KDM2B_26808549_Chip-Seq_DND41_Human1.25103072
102STAT3_1855785_ChIP-Seq_MESCs_Mouse1.24446367
103NELFA_20434984_ChIP-Seq_ESCs_Mouse1.24197575
104KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.23799586
105DCP1A_22483619_ChIP-Seq_HELA_Human1.22644972
106NR3C1_23031785_ChIP-Seq_PC12_Mouse1.21529384
107GATA3_20176728_ChIP-ChIP_TSCs_Mouse1.21121241
108IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.19872629
109HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.19390605
110KDM2B_26808549_Chip-Seq_SUP-B15_Human1.19377305
111POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.19362421
112KLF4_18555785_ChIP-Seq_MESCs_Mouse1.18963895
113* SOX2_20726797_ChIP-Seq_SW620_Human1.18732970
114RXR_22158963_ChIP-Seq_LIVER_Mouse1.18633509
115FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.17852906
116CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.17607135
117MYC_18555785_ChIP-Seq_MESCs_Mouse1.17534972
118GFI1B_20887958_ChIP-Seq_HPC-7_Mouse1.17532672
119E2F1_21310950_ChIP-Seq_MCF-7_Human1.16134787
120NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.14682914
121HOXB4_20404135_ChIP-ChIP_EML_Mouse1.13386969
122REST_19997604_ChIP-ChIP_NEURONS_Mouse1.11390736
123GATA2_22383799_ChIP-Seq_G1ME_Mouse1.11118972
124KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.11081156
125CTCF_27219007_Chip-Seq_ERYTHROID_Human1.10156552
126TBX5_21415370_ChIP-Seq_HL-1_Mouse1.08875631
127YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.08801593
128PPARA_22158963_ChIP-Seq_LIVER_Mouse1.07298747
129MYC_18358816_ChIP-ChIP_MESCs_Mouse1.07145822
130SIN3A_21632747_ChIP-Seq_MESCs_Mouse1.06733706
131NANOG_18555785_ChIP-Seq_MESCs_Mouse1.06389765
132THAP11_20581084_ChIP-Seq_MESCs_Mouse1.05380652
133* ELF1_20517297_ChIP-Seq_JURKAT_Human1.05301924
134BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.04685722
135RACK7_27058665_Chip-Seq_MCF-7_Human1.03921346
136ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.03160893
137CNOT3_19339689_ChIP-ChIP_MESCs_Mouse1.03016308
138* TFAP2A_17053090_ChIP-ChIP_MCF-7_Human1.02567988
139GATA1_19941827_ChIP-Seq_MEL_Mouse1.02463603
140SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.00840173
141LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.00773072
142P68_20966046_ChIP-Seq_HELA_Human1.00330194
143SA1_27219007_Chip-Seq_ERYTHROID_Human0.99770594
144CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.99348327
145MEF2A_21415370_ChIP-Seq_HL-1_Mouse0.99091721
146KDM5A_27292631_Chip-Seq_BREAST_Human0.98558934
147FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse0.98403752
148SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse0.98099424
149SPI1_23127762_ChIP-Seq_K562_Human0.98093946
150PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse0.97808888
151SRY_22984422_ChIP-ChIP_TESTIS_Rat0.97008360
152CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat0.96460437
153MEIS1_20887958_ChIP-Seq_HPC-7_Mouse0.96200791
154BCL6_25482012_ChIP-Seq_CML-JURL-MK1_Human0.95278233
155TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse0.95186220
156* HNF4A_19761587_ChIP-ChIP_CACO-2_Human0.94484792
157SIN3B_21632747_ChIP-Seq_MESCs_Mouse0.93979514
158FOXP3_21729870_ChIP-Seq_TREG_Human0.91937656
159ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.91733759
160EBNA1_20929547_Chip-Seq_RAJI-cells_Human0.87513634
161ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.86931570
162MYCN_18555785_ChIP-Seq_MESCs_Mouse0.86477838
163FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse0.83944984
164REST_18959480_ChIP-ChIP_MESCs_Mouse0.83838300
165TTF2_22483619_ChIP-Seq_HELA_Human0.83269987
166RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse0.82391578
167TRIM28_19339689_ChIP-ChIP_MESCs_Mouse0.82331667
168CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human0.81695220
169TFEB_21752829_ChIP-Seq_HELA_Human0.80725281
170ELF1_17652178_ChIP-ChIP_JURKAT_Human0.77947526

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0000013_abnormal_adipose_tissue6.94509574
2MP0003183_abnormal_peptide_metabolism5.27176579
3MP0005645_abnormal_hypothalamus_physiol4.27668724
4MP0005084_abnormal_gallbladder_morpholo4.05377236
5MP0005220_abnormal_exocrine_pancreas3.98458614
6MP0003122_maternal_imprinting3.98193461
7MP0003195_calcinosis3.95164538
8MP0000003_abnormal_adipose_tissue3.92219184
9MP0002938_white_spotting3.55763187
10MP0002396_abnormal_hematopoietic_system3.34735009
11MP0005365_abnormal_bile_salt3.22335599
12MP0003123_paternal_imprinting3.06122863
13MP0001944_abnormal_pancreas_morphology2.95566223
14MP0003111_abnormal_nucleus_morphology2.71450410
15MP0003763_abnormal_thymus_physiology2.64446302
16MP0003303_peritoneal_inflammation2.62363558
17MP0005451_abnormal_body_composition2.59348033
18MP0009333_abnormal_splenocyte_physiolog2.58134787
19MP0002693_abnormal_pancreas_physiology2.55474982
20MP0003959_abnormal_lean_body2.43322872
21MP0003693_abnormal_embryo_hatching2.43142973
22MP0001835_abnormal_antigen_presentation2.41170302
23MP0003436_decreased_susceptibility_to2.36352438
24MP0010094_abnormal_chromosome_stability2.36242235
25MP0001756_abnormal_urination2.23364501
26MP0002909_abnormal_adrenal_gland2.21522092
27MP0004957_abnormal_blastocyst_morpholog2.17294705
28MP0005408_hypopigmentation2.16477874
29MP0008260_abnormal_autophagy2.15935112
30MP0000685_abnormal_immune_system2.14414391
31MP0003121_genomic_imprinting2.14071811
32MP0002398_abnormal_bone_marrow2.12502024
33MP0001666_abnormal_nutrient_absorption2.10788423
34MP0003705_abnormal_hypodermis_morpholog2.08171450
35MP0006072_abnormal_retinal_apoptosis2.06951795
36MP0004264_abnormal_extraembryonic_tissu1.97938965
37MP0004233_abnormal_muscle_weight1.93522172
38MP0005025_abnormal_response_to1.92296473
39MP0005397_hematopoietic_system_phenotyp1.90682454
40MP0001545_abnormal_hematopoietic_system1.90682454
41MP0005379_endocrine/exocrine_gland_phen1.88605272
42MP0001790_abnormal_immune_system1.88577144
43MP0005387_immune_system_phenotype1.88577144
44MP0005000_abnormal_immune_tolerance1.88080840
45MP0005075_abnormal_melanosome_morpholog1.87774591
46MP0002638_abnormal_pupillary_reflex1.86357559
47MP0004043_abnormal_pH_regulation1.85653476
48MP0005083_abnormal_biliary_tract1.85478894
49MP0005464_abnormal_platelet_physiology1.83713571
50MP0002837_dystrophic_cardiac_calcinosis1.79378063
51MP0002722_abnormal_immune_system1.78609068
52MP0001800_abnormal_humoral_immune1.78153145
53MP0002877_abnormal_melanocyte_morpholog1.77631455
54MP0002751_abnormal_autonomic_nervous1.77475737
55MP0004947_skin_inflammation1.75672858
56MP0009278_abnormal_bone_marrow1.75192864
57MP0004147_increased_porphyrin_level1.75126908
58MP0002420_abnormal_adaptive_immunity1.74115930
59MP0002078_abnormal_glucose_homeostasis1.73180757
60MP0004808_abnormal_hematopoietic_stem1.72876588
61MP0000703_abnormal_thymus_morphology1.72406734
62MP0001819_abnormal_immune_cell1.71670730
63MP0002429_abnormal_blood_cell1.66992267
64MP0002138_abnormal_hepatobiliary_system1.66857990
65MP0005257_abnormal_intraocular_pressure1.66470379
66MP0009785_altered_susceptibility_to1.63236093
67MP0005375_adipose_tissue_phenotype1.62650599
68MP0002723_abnormal_immune_serum1.62547303
69MP0000490_abnormal_crypts_of1.62389600
70MP0005671_abnormal_response_to1.61019403
71MP0003077_abnormal_cell_cycle1.60614266
72MP0000689_abnormal_spleen_morphology1.60403932
73MP0000716_abnormal_immune_system1.58323823
74MP0002132_abnormal_respiratory_system1.56656045
75MP0000569_abnormal_digit_pigmentation1.56305843
76MP0005636_abnormal_mineral_homeostasis1.55239277
77MP0002419_abnormal_innate_immunity1.55032990
78MP0002452_abnormal_antigen_presenting1.53419342
79MP0001730_embryonic_growth_arrest1.49894678
80MP0002405_respiratory_system_inflammati1.49115288
81MP0006054_spinal_hemorrhage1.45365199
82MP0008961_abnormal_basal_metabolism1.44306457
83MP0008057_abnormal_DNA_replication1.42102095
84MP0008438_abnormal_cutaneous_collagen1.40743209
85MP0008058_abnormal_DNA_repair1.39957016
86MP0003453_abnormal_keratinocyte_physiol1.36784353
87MP0003787_abnormal_imprinting1.36277556
88MP0003566_abnormal_cell_adhesion1.35793729
89MP0010386_abnormal_urinary_bladder1.33978558
90MP0000678_abnormal_parathyroid_gland1.33237334
91MP0002019_abnormal_tumor_incidence1.32663871
92MP0000350_abnormal_cell_proliferation1.31135869
93MP0010155_abnormal_intestine_physiology1.31010626
94MP0002166_altered_tumor_susceptibility1.29320819
95MP0002148_abnormal_hypersensitivity_rea1.29316112
96MP0005058_abnormal_lysosome_morphology1.28574944
97MP0000858_altered_metastatic_potential1.28316418
98MP0000313_abnormal_cell_death1.27560373
99MP0005076_abnormal_cell_differentiation1.26432446
100MP0001853_heart_inflammation1.23267028
101MP0003172_abnormal_lysosome_physiology1.23196851
102MP0001873_stomach_inflammation1.22816807
103MP0006292_abnormal_olfactory_placode1.22690826
104MP0009931_abnormal_skin_appearance1.20850144
105MP0003786_premature_aging1.19852331
106MP0004019_abnormal_vitamin_homeostasis1.19229419
107MP0008932_abnormal_embryonic_tissue1.18066404
108MP0001764_abnormal_homeostasis1.13388866
109MP0002060_abnormal_skin_morphology1.12939589
110MP0001765_abnormal_ion_homeostasis1.12864125
111MP0010234_abnormal_vibrissa_follicle1.12759255
112MP0001849_ear_inflammation1.12748065
113MP0004185_abnormal_adipocyte_glucose1.12195873
114MP0002080_prenatal_lethality1.08023775
115MP0005501_abnormal_skin_physiology1.07550257
116MP0005332_abnormal_amino_acid1.06891776
117MP0003868_abnormal_feces_composition1.06508416
118MP0003656_abnormal_erythrocyte_physiolo1.05213415
119MP0001845_abnormal_inflammatory_respons1.04665360
120MP0001661_extended_life_span1.04109487
121MP0002006_tumorigenesis1.01657615
122MP0003879_abnormal_hair_cell1.01179501
123MP0010307_abnormal_tumor_latency1.00798190
124MP0005621_abnormal_cell_physiology0.99135217
125MP0005085_abnormal_gallbladder_physiolo0.97314478
126MP0000613_abnormal_salivary_gland0.96611400
127MP0009643_abnormal_urine_homeostasis0.95795723
128MP0001216_abnormal_epidermal_layer0.95394175
129MP0006082_CNS_inflammation0.95005997
130MP0002086_abnormal_extraembryonic_tissu0.94893369
131MP0003953_abnormal_hormone_level0.93557711
132MP0003866_abnormal_defecation0.93231896
133MP0008469_abnormal_protein_level0.93144989
134MP0008877_abnormal_DNA_methylation0.90916101
135MP0002796_impaired_skin_barrier0.90691737
136MP0010352_gastrointestinal_tract_polyps0.89745723
137MP0004381_abnormal_hair_follicle0.89587725
138MP0004270_analgesia0.89284616
139MP0005448_abnormal_energy_balance0.88037366
140MP0000631_abnormal_neuroendocrine_gland0.80875209
141MP0005384_cellular_phenotype0.80574351
142MP0001915_intracranial_hemorrhage0.80299529
143MP0006035_abnormal_mitochondrial_morpho0.79948838
144MP0002139_abnormal_hepatobiliary_system0.79774759
145MP0003890_abnormal_embryonic-extraembry0.78956908
146MP0001672_abnormal_embryogenesis/_devel0.78920263
147MP0005380_embryogenesis_phenotype0.78920263
148MP0005310_abnormal_salivary_gland0.78776718
149MP0003984_embryonic_growth_retardation0.77749639
150MP0001533_abnormal_skeleton_physiology0.77443411
151MP0003221_abnormal_cardiomyocyte_apopto0.76499723
152MP0005452_abnormal_adipose_tissue0.75939597
153MP0001664_abnormal_digestion0.69863103
154MP0001986_abnormal_taste_sensitivity0.69175790
155MP0005253_abnormal_eye_physiology0.67038960
156MP0002184_abnormal_innervation0.64279594
157MP0003119_abnormal_digestive_system0.63866541
158MP0001348_abnormal_lacrimal_gland0.61220115
159MP0003300_gastrointestinal_ulcer0.61167105
160MP0008789_abnormal_olfactory_epithelium0.60550173
161MP0001502_abnormal_circadian_rhythm0.60392443
162MP0003252_abnormal_bile_duct0.58669669
163MP0001485_abnormal_pinna_reflex0.58188869
164MP0002118_abnormal_lipid_homeostasis0.57857064
165MP0002177_abnormal_outer_ear0.55293134
166MP0002970_abnormal_white_adipose0.53019894
167MP0001186_pigmentation_phenotype0.52919520
168MP0002090_abnormal_vision0.52014427
169MP0002928_abnormal_bile_duct0.51704451
170MP0002971_abnormal_brown_adipose0.50916779
171MP0001270_distended_abdomen0.50864809
172MP0002098_abnormal_vibrissa_morphology0.50616125
173MP0004272_abnormal_basement_membrane0.47517547
174MP0008007_abnormal_cellular_replicative0.47408230
175MP0006036_abnormal_mitochondrial_physio0.47301441
176MP0002069_abnormal_eating/drinking_beha0.46493959
177MP0002896_abnormal_bone_mineralization0.46146631
178MP0009780_abnormal_chondrocyte_physiolo0.45937455
179MP0003806_abnormal_nucleotide_metabolis0.45777392
180MP0003638_abnormal_response/metabolism_0.43851830
181MP0005535_abnormal_body_temperature0.42604030
182MP0003329_amyloid_beta_deposits0.42329277
183MP0002876_abnormal_thyroid_physiology0.41836395
184MP0009642_abnormal_blood_homeostasis0.41076130
185MP0000230_abnormal_systemic_arterial0.40892209
186MP0002557_abnormal_social/conspecific_i0.40369695
187MP0005499_abnormal_olfactory_system0.40187157
188MP0005394_taste/olfaction_phenotype0.40187157
189MP0002009_preneoplasia0.39162015
190MP0009703_decreased_birth_body0.39116323

Predicted human phenotypes

RankGene SetZ-score
1Retinal atrophy (HP:0001105)6.52004732
2Elevated circulating parathyroid hormone (PTH) level (HP:0003165)6.01840225
3Hyperinsulinemic hypoglycemia (HP:0000825)5.76120366
4Hypoglycemic seizures (HP:0002173)5.40090207
5Hypoglycemic coma (HP:0001325)5.33995421
6Abnormality of calcium-phosphate metabolism (HP:0100530)5.25898240
7Hyperglycemia (HP:0003074)5.22165535
8Abnormality of the pancreatic islet cells (HP:0006476)5.10538998
9Abnormality of endocrine pancreas physiology (HP:0012093)5.10538998
10Ketoacidosis (HP:0001993)4.70732768
11Pancreatic islet-cell hyperplasia (HP:0004510)4.64127209
12Abnormal gallbladder physiology (HP:0012438)4.44899228
13Cholecystitis (HP:0001082)4.44899228
14Late onset (HP:0003584)4.41426952
15Abnormality of aromatic amino acid family metabolism (HP:0004338)4.37632678
16Reticulocytosis (HP:0001923)4.37398128
17Symptomatic seizures (HP:0011145)4.30552889
18Lipid accumulation in hepatocytes (HP:0006561)3.78109090
19Agitation (HP:0000713)3.63358251
20Polycythemia (HP:0001901)3.49716212
21Orthostatic hypotension (HP:0001278)3.39031573
22Hypochromic microcytic anemia (HP:0004840)3.34339168
23Ketosis (HP:0001946)3.34277831
24Menstrual irregularities (HP:0000858)3.34273711
25Large for gestational age (HP:0001520)3.33911869
26Dysautonomia (HP:0002459)3.22798201
27Abnormality of reticulocytes (HP:0004312)3.20609354
28Pheochromocytoma (HP:0002666)3.19055569
29Hyperparathyroidism (HP:0000843)3.16006795
30Cholelithiasis (HP:0001081)3.09470207
31Neuroendocrine neoplasm (HP:0100634)3.09306188
32Nonimmune hydrops fetalis (HP:0001790)3.03586140
33Onycholysis (HP:0001806)3.03206441
34White forelock (HP:0002211)3.00739743
35Osteomalacia (HP:0002749)3.00186891
36Enlarged kidneys (HP:0000105)2.99327445
37Abnormality of the fovea (HP:0000493)2.95195875
38Recurrent viral infections (HP:0004429)2.90787334
39Hypoplasia of the fovea (HP:0007750)2.87349740
40Aplasia/Hypoplasia of the fovea (HP:0008060)2.87349740
41Cellulitis (HP:0100658)2.86564916
42Abnormality of long-chain fatty-acid metabolism (HP:0010964)2.85960479
43Hypochromic anemia (HP:0001931)2.85032530
44Ankyloglossia (HP:0010296)2.84672745
45Growth hormone excess (HP:0000845)2.80798695
46Poikilocytosis (HP:0004447)2.74628122
47Increased IgE level (HP:0003212)2.74217612
48Hypertensive crisis (HP:0100735)2.71119173
49Mask-like facies (HP:0000298)2.68619232
50Patchy hypopigmentation of hair (HP:0011365)2.65793130
51Hypoplastic labia majora (HP:0000059)2.63572857
52Obstructive lung disease (HP:0006536)2.63565587
53Chronic obstructive pulmonary disease (HP:0006510)2.63565587
54Hepatoblastoma (HP:0002884)2.63086759
55Abnormal gallbladder morphology (HP:0012437)2.61354640
56Hypercortisolism (HP:0001578)2.61146163
57Blue irides (HP:0000635)2.60349195
58Abnormality of nail color (HP:0100643)2.59627744
59Gout (HP:0001997)2.58937701
60Abnormal hemoglobin (HP:0011902)2.58033522
61Missing ribs (HP:0000921)2.56277361
62Gastrointestinal inflammation (HP:0004386)2.55228491
63Papilledema (HP:0001085)2.55009520
64Prolonged bleeding time (HP:0003010)2.51667678
65Eczematoid dermatitis (HP:0000976)2.48212516
66Microcytic anemia (HP:0001935)2.44310665
67Congenital sensorineural hearing impairment (HP:0008527)2.43692542
68Colitis (HP:0002583)2.43110453
69Cortical visual impairment (HP:0100704)2.43004826
70Long toe (HP:0010511)2.42301062
71Insomnia (HP:0100785)2.41028353
7211 pairs of ribs (HP:0000878)2.40655269
73Inflammation of the large intestine (HP:0002037)2.38717317
74Autoimmune hemolytic anemia (HP:0001890)2.37933797
75Generalized hyperpigmentation (HP:0007440)2.37778839
76Abnormality of vitamin B metabolism (HP:0004340)2.36044803
77Slender long bone (HP:0003100)2.35923848
78IgM deficiency (HP:0002850)2.35847813
79Abnormality of T cell physiology (HP:0011840)2.34630457
80Abnormality of vitamin metabolism (HP:0100508)2.34152757
81Meningitis (HP:0001287)2.34047616
82Abnormality of the labia majora (HP:0012881)2.32685788
83Abnormal delayed hypersensitivity skin test (HP:0002963)2.32510747
84Urticaria (HP:0001025)2.29673731
85Hypsarrhythmia (HP:0002521)2.28652983
86EEG with generalized epileptiform discharges (HP:0011198)2.28076885
87Aplasia/Hypoplasia of the thymus (HP:0010515)2.26436507
88Dysostosis multiplex (HP:0000943)2.26379976
89Neoplasm of the thyroid gland (HP:0100031)2.25668341
90Agammaglobulinemia (HP:0004432)2.24161410
91Abnormal blistering of the skin (HP:0008066)2.23609761
92Abnormality of the heme biosynthetic pathway (HP:0010472)2.23258769
93Hyperphosphatemia (HP:0002905)2.22589503
94Increased serum ferritin (HP:0003281)2.21945848
95Testicular neoplasm (HP:0010788)2.20839752
96Ridged nail (HP:0001807)2.19821761
97Epileptiform EEG discharges (HP:0011182)2.19170778
98Acanthocytosis (HP:0001927)2.18953951
99Increased hepatocellular lipid droplets (HP:0006565)2.18683947
100Ileus (HP:0002595)2.17976940
101Paralysis (HP:0003470)2.17848589
102Panhypogammaglobulinemia (HP:0003139)2.17600213
103Petechiae (HP:0000967)2.14629791
104Recurrent bacterial skin infections (HP:0005406)2.14521065
105Parkinsonism with favorable response to dopaminergic medication (HP:0002548)2.11833938
106Atelectasis (HP:0100750)2.10476085
107Recurrent abscess formation (HP:0002722)2.09556917
108Insulin resistance (HP:0000855)2.09515904
109Restlessness (HP:0000711)2.09274502
110Pustule (HP:0200039)2.08240841
111Granulocytopenia (HP:0001913)2.07317751
112Prominent metopic ridge (HP:0005487)2.06928189
113Recurrent fungal infections (HP:0002841)2.06597880
114Mediastinal lymphadenopathy (HP:0100721)2.06430106
115Abnormality of the gallbladder (HP:0005264)2.06416772
116Cardiomegaly (HP:0001640)2.06369194
117Hemiparesis (HP:0001269)2.04788310
118Urinary glycosaminoglycan excretion (HP:0003541)2.04692644
119Mucopolysacchariduria (HP:0008155)2.04692644
120Microvesicular hepatic steatosis (HP:0001414)2.04018965
121Progressive neurologic deterioration (HP:0002344)2.03918246
122Acute hepatic failure (HP:0006554)2.02613384
123Skin ulcer (HP:0200042)2.02363059
124Abnormality of iron homeostasis (HP:0011031)2.01946846
125Abnormality of macrophages (HP:0004311)2.01621936
126Cutaneous photosensitivity (HP:0000992)2.00251107
127Hypoventilation (HP:0002791)1.99700366
128Type II lissencephaly (HP:0007260)1.99623851
129Seborrheic dermatitis (HP:0001051)1.98988628
130Pallor (HP:0000980)1.98828622
131Upper limb muscle weakness (HP:0003484)1.98750982
132Osteomyelitis (HP:0002754)1.98260092
133Abnormality of cells of the lymphoid lineage (HP:0012140)1.97852737
134Hand muscle atrophy (HP:0009130)1.97289509
135Cavernous hemangioma (HP:0001048)1.96692909
136Skin rash (HP:0000988)1.96683872
137Congenital glaucoma (HP:0001087)1.95973671
138Abnormality of oral frenula (HP:0000190)1.95532672
139Intestinal polyposis (HP:0200008)1.94526184
140Neuroblastic tumors (HP:0004376)1.94438739
141Peripheral primitive neuroectodermal neoplasm (HP:0030067)1.94438739
142Neuroblastoma (HP:0003006)1.94438739
143Primitive neuroectodermal tumor (HP:0030065)1.94438739
144Gastrointestinal dysmotility (HP:0002579)1.94165338
145Neoplasm of the adrenal gland (HP:0100631)1.94030704
146Hypotension (HP:0002615)1.93619219
147Proximal tubulopathy (HP:0000114)1.93050592
148Abnormality of T cells (HP:0002843)1.92995847
149Lymphopenia (HP:0001888)1.92821103
150Labial hypoplasia (HP:0000066)1.90809568
151Insulin-resistant diabetes mellitus (HP:0000831)1.89810246
152Increased IgM level (HP:0003496)1.89381742
153Epistaxis (HP:0000421)1.88921548
154Fatigue (HP:0012378)1.88864487
155Impaired platelet aggregation (HP:0003540)1.88584462
156Abnormal platelet function (HP:0011869)1.88584462
157Ragged-red muscle fibers (HP:0003200)1.87799008
158Oral leukoplakia (HP:0002745)1.87379712
159Encephalitis (HP:0002383)1.87103474
160Hyperbilirubinemia (HP:0002904)1.86690384
161Lymphoma (HP:0002665)1.85657244
162Hepatosplenomegaly (HP:0001433)1.85356438
163Abnormality of renal resorption (HP:0011038)1.85144112
164Myositis (HP:0100614)1.85016686
165Gastrointestinal infarctions (HP:0005244)1.84736268
166Truncus arteriosus (HP:0001660)1.84333971
167Squamous cell carcinoma (HP:0002860)1.83690364
168Increased CSF protein (HP:0002922)1.83329016
169Papillary thyroid carcinoma (HP:0002895)1.82606864
170Viral hepatitis (HP:0006562)1.81724459
171Exocrine pancreatic insufficiency (HP:0001738)1.80992712
172Abnormality of dental color (HP:0011073)1.80560952
173Type I transferrin isoform profile (HP:0003642)1.80234650
174Rough bone trabeculation (HP:0100670)1.80114217
175Gastrointestinal stroma tumor (HP:0100723)1.78396853
176Milia (HP:0001056)1.78034227
177Tachypnea (HP:0002789)1.77994183
178IgA deficiency (HP:0002720)1.77964618
179Abnormal number of erythroid precursors (HP:0012131)1.76369610
180Abnormality of cells of the erythroid lineage (HP:0012130)1.76344539
181Selective tooth agenesis (HP:0001592)1.76085741
182Progressive muscle weakness (HP:0003323)1.76037707
183Dry hair (HP:0011359)1.75304449
184Abnormality of the peritoneum (HP:0002585)1.73332352
185Adrenal overactivity (HP:0002717)1.73034994
186Abnormal pancreas size (HP:0012094)1.72934907
187Hypoplastic female external genitalia (HP:0012815)1.72516839
188Abnormality of mucopolysaccharide metabolism (HP:0011020)1.72454247
189Abnormality of glycosaminoglycan metabolism (HP:0004371)1.72454247
190Thick nail (HP:0001805)1.72053811
191Thrombocytosis (HP:0001894)1.71535381
192Slow saccadic eye movements (HP:0000514)1.71332097
193Elevated erythrocyte sedimentation rate (HP:0003565)1.70458258
194Polygenic inheritance (HP:0010982)1.70050477
195Vasculitis (HP:0002633)1.67960260

Predicted kinase interactions (KEA)

RankGene SetZ-score
1WNK39.89037149
2MAPK158.53173501
3PRPF4B3.80714287
4PIK3CG3.59731019
5WNK43.58528049
6STK163.02401077
7SMG12.93281991
8RIPK42.59574615
9MAP4K12.57347903
10NME22.44904533
11IRAK32.20685043
12EEF2K2.10569476
13UHMK11.98904485
14MAP3K101.98378785
15TAOK21.96375201
16MAP3K21.86292032
17CDK121.85098315
18ICK1.84289527
19EPHA31.82125109
20MAP2K31.81359411
21PIM21.71533115
22CLK11.70658961
23DYRK1B1.66912406
24JAK31.59570201
25BUB11.59104365
26MAP3K81.58950602
27CDC71.58082955
28BCKDK1.56746047
29IRAK41.55653681
30HIPK21.52532768
31INSRR1.48664718
32EIF2AK11.45424211
33MAP3K111.42153639
34TESK21.37244554
35TYK21.34243127
36ERN11.34142810
37MAP3K131.27361024
38BMPR1B1.24475606
39CDC42BPA1.23664477
40CDK41.22325257
41SCYL21.21397487
42BRSK11.18782359
43BTK1.18388716
44TBK11.15594074
45MAP2K21.13998385
46PIM11.10378219
47PTK61.09392991
48TTK1.07973194
49EIF2AK31.07917874
50FGFR41.07871765
51STK101.07178609
52NUAK11.06175842
53GRK61.06049423
54MAP3K141.05895241
55BRSK21.02797574
56SRPK10.99435513
57NEK10.97009249
58BMX0.95098649
59FES0.94856806
60FER0.93146851
61EPHB10.93035528
62WNK10.92443376
63VRK20.91106101
64CAMKK20.89014219
65NME10.88818845
66RPS6KB20.88420958
67SYK0.87525293
68ARAF0.87197590
69MAP3K10.83132669
70PAK30.80940874
71ALK0.77302521
72PTK20.77034936
73STK38L0.76436942
74RPS6KA50.75564744
75CDK70.75052883
76TAOK10.70788884
77STK40.69734332
78PASK0.68780366
79DAPK10.67048075
80MTOR0.66641604
81EPHA20.65674290
82FGFR30.64920805
83IKBKE0.64049226
84PBK0.63505582
85DYRK30.63476743
86TRIB30.62854503
87CDK80.62336112
88KSR20.61228515
89TNK20.60968157
90ATR0.60886774
91MAPKAPK30.60543541
92HCK0.60508973
93GRK70.60337957
94BCR0.60119295
95TTN0.59909033
96LYN0.58624419
97ZAP700.58617381
98MATK0.58455039
99ITK0.57910113
100LCK0.54314566
101ADRBK20.53964664
102CSK0.53725574
103PAK40.53531367
104TAOK30.52601099
105NLK0.52393782
106CHEK10.51916204
107BRD40.51403145
108NTRK30.50641122
109SIK30.50559560
110MAP2K10.50061295
111TEC0.49929599
112IKBKB0.48746512
113DAPK20.48019080
114JAK10.47836012
115KIT0.47011789
116FGR0.46906773
117DYRK20.46855104
118MAPKAPK20.46462759
119SIK10.45821160
120MAPKAPK50.45216907
121IRAK10.43844660
122DYRK1A0.43249446
123IRAK20.42325898
124PKN20.42055460
125BRAF0.41793967
126VRK10.41547257
127TXK0.39352938
128AURKB0.39010455
129MAPK110.38958399
130LRRK20.38208632
131PAK10.37215801
132CDK60.36333623
133RPS6KA40.35874663
134CDK20.35615888
135MAPK120.35594338
136PDPK10.35420620
137FRK0.34788992
138ERBB40.33146606
139KSR10.32588911
140ILK0.32303392
141PRKG20.32086147
142CAMK2D0.30944710
143RPS6KB10.30263873
144RAF10.28507362
145RET0.26818291
146CSNK1G30.22100597
147TSSK60.21147150
148TESK10.19623181
149SGK10.19364054
150NTRK10.19244669
151KDR0.19176766
152CAMK2B0.19132637
153PRKDC0.18959974
154MAP3K30.18645981
155NEK60.18644755
156CSNK1A10.17797471
157GRK10.16675714
158CCNB10.16652670
159CSNK1G10.16370883
160AKT30.16094124
161FLT30.15125386
162MAPK30.14569630
163PRKCI0.14340051
164RPS6KA10.13857204
165CHEK20.12771366
166JAK20.12336766
167NEK20.11929608
168CSNK1E0.11187610
169MAPK140.09451047
170RIPK10.09160166
171AURKA0.09064982
172MARK30.08107444
173MAPK80.08051613
174CSNK1G20.07798809
175RPS6KA30.07095342

Predicted pathways (KEGG)

RankGene SetZ-score
1Maturity onset diabetes of the young_Homo sapiens_hsa049509.04306698
2Protein export_Homo sapiens_hsa030605.57425273
3DNA replication_Homo sapiens_hsa030303.52191874
4Insulin secretion_Homo sapiens_hsa049112.91858408
5Pancreatic secretion_Homo sapiens_hsa049722.81831234
6Protein processing in endoplasmic reticulum_Homo sapiens_hsa041412.81348555
7Folate biosynthesis_Homo sapiens_hsa007902.80583732
8Type I diabetes mellitus_Homo sapiens_hsa049402.42668491
9Primary immunodeficiency_Homo sapiens_hsa053402.02442298
10Glycosaminoglycan degradation_Homo sapiens_hsa005312.00320854
11Fat digestion and absorption_Homo sapiens_hsa049751.94986428
12Sulfur metabolism_Homo sapiens_hsa009201.86272288
13Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.86067868
14Vibrio cholerae infection_Homo sapiens_hsa051101.83380453
15Measles_Homo sapiens_hsa051621.78022078
16Base excision repair_Homo sapiens_hsa034101.76260037
17Chronic myeloid leukemia_Homo sapiens_hsa052201.75815159
18B cell receptor signaling pathway_Homo sapiens_hsa046621.71659030
19Pentose phosphate pathway_Homo sapiens_hsa000301.69951622
20Biosynthesis of amino acids_Homo sapiens_hsa012301.66820602
21Cell cycle_Homo sapiens_hsa041101.64833608
22Herpes simplex infection_Homo sapiens_hsa051681.63520517
23Protein digestion and absorption_Homo sapiens_hsa049741.60584531
24Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.60071136
25N-Glycan biosynthesis_Homo sapiens_hsa005101.58317943
26Viral carcinogenesis_Homo sapiens_hsa052031.53974031
27One carbon pool by folate_Homo sapiens_hsa006701.53673737
28Influenza A_Homo sapiens_hsa051641.50948280
29SNARE interactions in vesicular transport_Homo sapiens_hsa041301.43816652
30Non-small cell lung cancer_Homo sapiens_hsa052231.38575038
31RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.37682644
32Malaria_Homo sapiens_hsa051441.37258021
33Selenocompound metabolism_Homo sapiens_hsa004501.37019199
34Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.36396581
35NF-kappa B signaling pathway_Homo sapiens_hsa040641.35725872
36Parkinsons disease_Homo sapiens_hsa050121.34926364
37Central carbon metabolism in cancer_Homo sapiens_hsa052301.34454916
38Leishmaniasis_Homo sapiens_hsa051401.33781585
39Systemic lupus erythematosus_Homo sapiens_hsa053221.33029529
40Hepatitis B_Homo sapiens_hsa051611.31879679
41Oxidative phosphorylation_Homo sapiens_hsa001901.31619665
42Pancreatic cancer_Homo sapiens_hsa052121.31039321
43Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.31019824
44Circadian rhythm_Homo sapiens_hsa047101.30323041
45Toll-like receptor signaling pathway_Homo sapiens_hsa046201.29784017
46Cocaine addiction_Homo sapiens_hsa050301.28539402
47Lysosome_Homo sapiens_hsa041421.27688881
48Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.27095133
49Glucagon signaling pathway_Homo sapiens_hsa049221.26371977
50Apoptosis_Homo sapiens_hsa042101.26364539
51Fructose and mannose metabolism_Homo sapiens_hsa000511.24789423
52Nitrogen metabolism_Homo sapiens_hsa009101.24428278
53Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.21228723
54Linoleic acid metabolism_Homo sapiens_hsa005911.20977203
55Other glycan degradation_Homo sapiens_hsa005111.20605767
56Epstein-Barr virus infection_Homo sapiens_hsa051691.18952508
57Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.15294435
58African trypanosomiasis_Homo sapiens_hsa051431.15086341
59Shigellosis_Homo sapiens_hsa051311.12634704
60alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.11408703
61Osteoclast differentiation_Homo sapiens_hsa043801.09117465
62Nucleotide excision repair_Homo sapiens_hsa034201.08510913
63Allograft rejection_Homo sapiens_hsa053301.08126649
64Carbon metabolism_Homo sapiens_hsa012001.07694275
65Autoimmune thyroid disease_Homo sapiens_hsa053201.04210245
66HTLV-I infection_Homo sapiens_hsa051661.03593727
67Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.02123643
68T cell receptor signaling pathway_Homo sapiens_hsa046601.02068226
69Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.01892139
70VEGF signaling pathway_Homo sapiens_hsa043701.01669589
71Fatty acid degradation_Homo sapiens_hsa000711.01634120
722-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.00078496
73Alzheimers disease_Homo sapiens_hsa050100.99902936
74Proteasome_Homo sapiens_hsa030500.99004205
75Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.98478300
76Jak-STAT signaling pathway_Homo sapiens_hsa046300.97251423
77Hematopoietic cell lineage_Homo sapiens_hsa046400.96240454
78Prion diseases_Homo sapiens_hsa050200.95558928
79Non-homologous end-joining_Homo sapiens_hsa034500.94999300
80Hepatitis C_Homo sapiens_hsa051600.94172846
81Toxoplasmosis_Homo sapiens_hsa051450.94120000
82Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.90172973
83ABC transporters_Homo sapiens_hsa020100.88855593
84Amphetamine addiction_Homo sapiens_hsa050310.88365411
85Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.83542708
86Huntingtons disease_Homo sapiens_hsa050160.81300933
87Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.80327622
88Graft-versus-host disease_Homo sapiens_hsa053320.79686621
89Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.79584847
90Regulation of autophagy_Homo sapiens_hsa041400.79221552
91Small cell lung cancer_Homo sapiens_hsa052220.78784354
92Intestinal immune network for IgA production_Homo sapiens_hsa046720.78060093
93Alcoholism_Homo sapiens_hsa050340.76853237
94Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.76188059
95TNF signaling pathway_Homo sapiens_hsa046680.76114543
96Thyroid hormone synthesis_Homo sapiens_hsa049180.75685331
97Viral myocarditis_Homo sapiens_hsa054160.75684265
98Ether lipid metabolism_Homo sapiens_hsa005650.74581753
99Galactose metabolism_Homo sapiens_hsa000520.73885038
100HIF-1 signaling pathway_Homo sapiens_hsa040660.73796609
101AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.73219085
102Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.71875722
103Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.71468535
104Drug metabolism - other enzymes_Homo sapiens_hsa009830.68804806
105Arachidonic acid metabolism_Homo sapiens_hsa005900.66994148
106Circadian entrainment_Homo sapiens_hsa047130.66809820
107Type II diabetes mellitus_Homo sapiens_hsa049300.66338126
108RNA degradation_Homo sapiens_hsa030180.66089758
109Tuberculosis_Homo sapiens_hsa051520.65118239
110Legionellosis_Homo sapiens_hsa051340.64113170
111Homologous recombination_Homo sapiens_hsa034400.62850957
112Vascular smooth muscle contraction_Homo sapiens_hsa042700.57473200
113Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.57361565
114Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.57361087
115Renin secretion_Homo sapiens_hsa049240.56742590
116Renin-angiotensin system_Homo sapiens_hsa046140.56468636
117Asthma_Homo sapiens_hsa053100.56326894
118Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.56170377
119Dopaminergic synapse_Homo sapiens_hsa047280.55654092
120Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.55388428
121RNA transport_Homo sapiens_hsa030130.54821120
122Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.54331403
123RNA polymerase_Homo sapiens_hsa030200.53236516
124Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.52676191
125Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.51612772
126MicroRNAs in cancer_Homo sapiens_hsa052060.51045329
127Renal cell carcinoma_Homo sapiens_hsa052110.50731362
128NOD-like receptor signaling pathway_Homo sapiens_hsa046210.50148847
129Endometrial cancer_Homo sapiens_hsa052130.49332196
130Glioma_Homo sapiens_hsa052140.48712247
131Colorectal cancer_Homo sapiens_hsa052100.48476363
132Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.47670428
133Prolactin signaling pathway_Homo sapiens_hsa049170.47188595
134cAMP signaling pathway_Homo sapiens_hsa040240.45443443
135Salmonella infection_Homo sapiens_hsa051320.45086561
136Aldosterone synthesis and secretion_Homo sapiens_hsa049250.44883613
137Sulfur relay system_Homo sapiens_hsa041220.43711394
138Spliceosome_Homo sapiens_hsa030400.43667202
139mTOR signaling pathway_Homo sapiens_hsa041500.43610019
140Chemokine signaling pathway_Homo sapiens_hsa040620.43388122
141Starch and sucrose metabolism_Homo sapiens_hsa005000.40224219
142Tryptophan metabolism_Homo sapiens_hsa003800.40219934
143Ribosome_Homo sapiens_hsa030100.40034763
144Estrogen signaling pathway_Homo sapiens_hsa049150.38346459
145Carbohydrate digestion and absorption_Homo sapiens_hsa049730.36805078
146Pyruvate metabolism_Homo sapiens_hsa006200.36631995
147Metabolic pathways_Homo sapiens_hsa011000.35186033
148Thyroid cancer_Homo sapiens_hsa052160.33326333
149Purine metabolism_Homo sapiens_hsa002300.33254868
150Arginine and proline metabolism_Homo sapiens_hsa003300.32932157
151Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.32767400
152Pyrimidine metabolism_Homo sapiens_hsa002400.32431749
153Fatty acid metabolism_Homo sapiens_hsa012120.32199921
154Synaptic vesicle cycle_Homo sapiens_hsa047210.31612472
155Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.31122672
156Primary bile acid biosynthesis_Homo sapiens_hsa001200.30087518
157Peroxisome_Homo sapiens_hsa041460.29703134
158Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.29337365
159Serotonergic synapse_Homo sapiens_hsa047260.28496687
160Glutathione metabolism_Homo sapiens_hsa004800.27290568
161Antigen processing and presentation_Homo sapiens_hsa046120.26476038
162Notch signaling pathway_Homo sapiens_hsa043300.25284680
163Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.24093556
164Transcriptional misregulation in cancer_Homo sapiens_hsa052020.22873254
165Bladder cancer_Homo sapiens_hsa052190.20826955
166Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.20687928
167* GABAergic synapse_Homo sapiens_hsa047270.20538721
168Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.19371678
169Long-term depression_Homo sapiens_hsa047300.19026659
170mRNA surveillance pathway_Homo sapiens_hsa030150.19007778
171Insulin signaling pathway_Homo sapiens_hsa049100.18595574
172Caffeine metabolism_Homo sapiens_hsa002320.17384429
173Lysine degradation_Homo sapiens_hsa003100.17032413
174Acute myeloid leukemia_Homo sapiens_hsa052210.16339973
175Long-term potentiation_Homo sapiens_hsa047200.16212933
176Mismatch repair_Homo sapiens_hsa034300.16032492

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