SLC38A6

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1secondary metabolite biosynthetic process (GO:0044550)9.57136256
2regulation of short-term neuronal synaptic plasticity (GO:0048172)6.54634790
3microtubule depolymerization (GO:0007019)5.24990232
4pre-miRNA processing (GO:0031054)5.09407545
5leukotriene biosynthetic process (GO:0019370)4.64974121
6labyrinthine layer development (GO:0060711)4.60022418
7regulation of RNA export from nucleus (GO:0046831)4.58637063
8tryptophan catabolic process (GO:0006569)4.32798671
9indole-containing compound catabolic process (GO:0042436)4.32798671
10indolalkylamine catabolic process (GO:0046218)4.32798671
11kynurenine metabolic process (GO:0070189)4.32238052
12protein prenylation (GO:0018342)4.29266605
13prenylation (GO:0097354)4.29266605
14developmental pigmentation (GO:0048066)4.25501007
15tryptophan metabolic process (GO:0006568)4.10725223
16hypothalamus development (GO:0021854)4.09079201
17regulation of translation, ncRNA-mediated (GO:0045974)4.08292510
18negative regulation of translation involved in gene silencing by miRNA (GO:0035278)4.08292510
19negative regulation of translation, ncRNA-mediated (GO:0040033)4.08292510
20nuclear pore complex assembly (GO:0051292)4.07299182
21indolalkylamine metabolic process (GO:0006586)4.00870115
22histone H3-K36 demethylation (GO:0070544)3.96513472
23nuclear pore organization (GO:0006999)3.93975451
24negative regulation of histone methylation (GO:0031061)3.92654578
25prostate gland growth (GO:0060736)3.92401701
26response to pheromone (GO:0019236)3.87362281
27lipid particle organization (GO:0034389)3.86050099
28regulation of nucleobase-containing compound transport (GO:0032239)3.85504843
29phenol-containing compound biosynthetic process (GO:0046189)3.79331691
30regulation of attachment of spindle microtubules to kinetochore (GO:0051988)3.71854490
31negative regulation of mast cell activation (GO:0033004)3.67482414
32sulfation (GO:0051923)3.53104917
33histone H3-K9 demethylation (GO:0033169)3.53009892
34negative regulation of systemic arterial blood pressure (GO:0003085)3.45815403
35regulation of mRNA 3-end processing (GO:0031440)3.43894572
36protein localization to cilium (GO:0061512)3.42124694
37detection of light stimulus involved in sensory perception (GO:0050962)3.38686281
38detection of light stimulus involved in visual perception (GO:0050908)3.38686281
39tyrosine metabolic process (GO:0006570)3.38196288
40positive regulation of macroautophagy (GO:0016239)3.37174037
41positive regulation of mRNA 3-end processing (GO:0031442)3.36076432
42tachykinin receptor signaling pathway (GO:0007217)3.29005939
43cytoplasmic mRNA processing body assembly (GO:0033962)3.28658838
44positive regulation of nuclear-transcribed mRNA poly(A) tail shortening (GO:0060213)3.28407751
45regulation of nuclear-transcribed mRNA poly(A) tail shortening (GO:0060211)3.28407751
46positive regulation of chromosome segregation (GO:0051984)3.28349241
47epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)3.26468628
48epithelial cilium movement (GO:0003351)3.25971281
49leukotriene metabolic process (GO:0006691)3.22740878
50regulation of sequestering of triglyceride (GO:0010889)3.22169080
51regulation of spindle organization (GO:0090224)3.19602368
52regulation of mitotic spindle organization (GO:0060236)3.18743523
53interferon-gamma production (GO:0032609)3.16312809
54mitotic sister chromatid cohesion (GO:0007064)3.15610637
55pore complex assembly (GO:0046931)3.15580460
56detection of molecule of bacterial origin (GO:0032490)3.15331371
57secondary metabolic process (GO:0019748)3.14388768
58microtubule polymerization or depolymerization (GO:0031109)3.14198647
59peptidyl-lysine dimethylation (GO:0018027)3.13636705
60nerve growth factor signaling pathway (GO:0038180)3.12832683
61regulation of histone H3-K9 methylation (GO:0051570)3.10625702
62establishment of protein localization to Golgi (GO:0072600)3.08560909
63histone H2A monoubiquitination (GO:0035518)3.06789088
64melanocyte differentiation (GO:0030318)3.04916688
65protein K11-linked deubiquitination (GO:0035871)3.04441692
66phosphatidylinositol-3-phosphate biosynthetic process (GO:0036092)3.01187883
67coronary vasculature morphogenesis (GO:0060977)3.00566755
68neuronal action potential (GO:0019228)2.94556403
69regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay (GO:1900151)2.93419956
70positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay (GO2.93419956
71indole-containing compound metabolic process (GO:0042430)2.91709551
72peristalsis (GO:0030432)2.90014604
73histone demethylation (GO:0016577)2.87820052
74cell migration in hindbrain (GO:0021535)2.85744568
75pigmentation (GO:0043473)2.83959392
76histone H3-K4 trimethylation (GO:0080182)2.83105108
77protein localization to kinetochore (GO:0034501)2.82207107
78protein localization to endosome (GO:0036010)2.81668262
79positive regulation of autophagy (GO:0010508)2.81430820
80histone lysine demethylation (GO:0070076)2.81007558
81cilium or flagellum-dependent cell motility (GO:0001539)2.80947294
82amine catabolic process (GO:0009310)2.80810077
83cellular biogenic amine catabolic process (GO:0042402)2.80810077
84oligosaccharide catabolic process (GO:0009313)2.80019733
85stress granule assembly (GO:0034063)2.76628226
86monoubiquitinated protein deubiquitination (GO:0035520)2.76441328
87regulation of histone methylation (GO:0031060)2.75891100
88L-amino acid import (GO:0043092)2.74368234
89establishment of mitotic spindle orientation (GO:0000132)2.73620558
90negative regulation of cytosolic calcium ion concentration (GO:0051481)2.73604038
91peptidyl-lysine trimethylation (GO:0018023)2.73095641
92regulation of histone H3-K27 methylation (GO:0061085)2.71300927
93microglial cell activation (GO:0001774)2.71105947
94membrane depolarization during cardiac muscle cell action potential (GO:0086012)2.70793047
95positive regulation of mRNA processing (GO:0050685)2.70422889
96regulation of meiosis I (GO:0060631)2.70085180
97regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion (GO2.69973935
98regulation of calcineurin-NFAT signaling cascade (GO:0070884)2.69881294
99cilium movement (GO:0003341)2.69339590
100regulation of skeletal muscle contraction (GO:0014819)2.68600663
101behavioral response to nicotine (GO:0035095)2.68052501
102signal peptide processing (GO:0006465)2.67607759
103dopamine transport (GO:0015872)2.66189670
104protein demethylation (GO:0006482)2.65483695
105protein dealkylation (GO:0008214)2.65483695
106regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450912.63008936
107pigment cell differentiation (GO:0050931)2.62545472
108establishment of mitotic spindle localization (GO:0040001)2.60156361
109regulation of cardiac muscle contraction by calcium ion signaling (GO:0010882)2.59237052
110histone phosphorylation (GO:0016572)2.58183487
111protein targeting to Golgi (GO:0000042)2.58032478
112positive regulation of digestive system process (GO:0060456)2.55892793
113negative regulation of nitric oxide biosynthetic process (GO:0045019)2.55156127
114face morphogenesis (GO:0060325)2.55096723
115protein targeting to vacuole (GO:0006623)2.55017896
116protein targeting to lysosome (GO:0006622)2.55017896
117establishment of protein localization to vacuole (GO:0072666)2.55017896
118regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)2.53878826
119peptidyl-lysine methylation (GO:0018022)2.53145462
120gene silencing by RNA (GO:0031047)2.52715363
121NAD biosynthetic process (GO:0009435)2.51523476
122regulation of centriole replication (GO:0046599)2.50433491
123protein K63-linked deubiquitination (GO:0070536)2.48578957
124regulation of DNA endoreduplication (GO:0032875)2.48563871
125positive regulation of interleukin-8 biosynthetic process (GO:0045416)2.48525154
126neural tube formation (GO:0001841)2.48452799
127multicellular organism reproduction (GO:0032504)2.48421128
128membrane depolarization during action potential (GO:0086010)2.48120083
129lysosome organization (GO:0007040)2.47671393
130lytic vacuole organization (GO:0080171)2.47671393
131intracellular pH reduction (GO:0051452)2.47339147
132negative regulation of nitric-oxide synthase activity (GO:0051001)2.47237638
133response to parathyroid hormone (GO:0071107)2.47037336
134axonemal dynein complex assembly (GO:0070286)2.46271435
135positive regulation of cAMP-mediated signaling (GO:0043950)2.45024020
136cAMP catabolic process (GO:0006198)2.44822117
137establishment of spindle localization (GO:0051293)2.44751518
138primary amino compound metabolic process (GO:1901160)2.44726118
139alternative mRNA splicing, via spliceosome (GO:0000380)2.43940661
140G1 DNA damage checkpoint (GO:0044783)2.42827221
141iron ion import (GO:0097286)2.41869118
142establishment of spindle orientation (GO:0051294)2.41793743
143regulation of mRNA catabolic process (GO:0061013)2.41360974
144negative regulation of interleukin-12 production (GO:0032695)2.40624862
145alanine transport (GO:0032328)2.40105450
146serotonin metabolic process (GO:0042428)2.40085658
147positive regulation of mRNA catabolic process (GO:0061014)2.39138988
148regulation of sarcomere organization (GO:0060297)2.37754561
149adrenergic receptor signaling pathway (GO:0071875)2.37304993
150histone H3-K4 methylation (GO:0051568)2.37107794
151histone monoubiquitination (GO:0010390)2.36962222
152negative regulation of macroautophagy (GO:0016242)2.36727619
153nucleus organization (GO:0006997)2.36119961
154reflex (GO:0060004)2.35673357
155negative regulation of leukocyte mediated cytotoxicity (GO:0001911)2.35282515
156negative regulation of cell killing (GO:0031342)2.35282515
157positive regulation of cell size (GO:0045793)2.34881559
158flavonoid metabolic process (GO:0009812)2.34880559
159proline transport (GO:0015824)2.34340537
160aromatic amino acid family catabolic process (GO:0009074)2.33485416
161protein depolymerization (GO:0051261)2.33428695
162negative regulation of monooxygenase activity (GO:0032769)2.33117223
163retrograde transport, vesicle recycling within Golgi (GO:0000301)2.32918969
164response to epinephrine (GO:0071871)2.32676559
165central nervous system myelination (GO:0022010)2.31617131
166axon ensheathment in central nervous system (GO:0032291)2.31617131
167benzene-containing compound metabolic process (GO:0042537)2.31391325
168neurological system process involved in regulation of systemic arterial blood pressure (GO:0001976)2.31220049
169cilium organization (GO:0044782)2.29569343
170auditory receptor cell stereocilium organization (GO:0060088)2.29454980
171centrosome duplication (GO:0051298)2.29305172
172lung-associated mesenchyme development (GO:0060484)2.28948969
173regulation of somitogenesis (GO:0014807)2.28399057
174positive regulation of mRNA metabolic process (GO:1903313)2.27842427
175behavioral response to ethanol (GO:0048149)2.27585609
176adaptation of signaling pathway (GO:0023058)2.27416389
177cilium assembly (GO:0042384)2.26792072
178centrosome localization (GO:0051642)2.26175263
179fatty acid derivative biosynthetic process (GO:1901570)2.25338615
180icosanoid biosynthetic process (GO:0046456)2.25338615
181chromatin assembly (GO:0031497)2.24789582
182NLS-bearing protein import into nucleus (GO:0006607)2.24485977
183motile cilium assembly (GO:0044458)2.24392991
184sister chromatid segregation (GO:0000819)2.24237812
185mitotic G1 DNA damage checkpoint (GO:0031571)2.24199460
186negative regulation of neurotransmitter transport (GO:0051589)2.24186959
187negative regulation of protein localization to cell surface (GO:2000009)2.24166317
188regulation of mesenchymal to epithelial transition involved in metanephros morphogenesis (GO:00033392.24026789
189histone H3-K9 methylation (GO:0051567)2.23825790
190heart contraction (GO:0060047)2.23402963
191heart process (GO:0003015)2.23402963
192regulation of mononuclear cell migration (GO:0071675)2.23164001
193cilium morphogenesis (GO:0060271)2.22916520
194regulation of establishment of cell polarity (GO:2000114)2.22849728
195dendritic spine morphogenesis (GO:0060997)2.22428283
196righting reflex (GO:0060013)2.21991737
197negative regulation of intracellular estrogen receptor signaling pathway (GO:0033147)2.21098383
198melanin biosynthetic process (GO:0042438)11.9213788
199melanin metabolic process (GO:0006582)10.9033391

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1FOXM1_23109430_ChIP-Seq_U2OS_Human5.09456630
2FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse5.06920264
3E2F7_22180533_ChIP-Seq_HELA_Human4.87359868
4BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse4.78959147
5SALL1_21062744_ChIP-ChIP_HESCs_Human3.97952387
6EGR1_19374776_ChIP-ChIP_THP-1_Human3.51110301
7ZFP322A_24550733_ChIP-Seq_MESCs_Mouse3.46362243
8E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse3.26487084
9KDM5B_21448134_ChIP-Seq_MESCs_Mouse3.10369486
10NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.93240034
11* GBX2_23144817_ChIP-Seq_PC3_Human2.77237624
12EZH2_22144423_ChIP-Seq_EOC_Human2.70954904
13VDR_22108803_ChIP-Seq_LS180_Human2.69898722
14GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.61996210
15ZFP57_27257070_Chip-Seq_ESCs_Mouse2.55543682
16* POU3F2_20337985_ChIP-ChIP_501MEL_Human2.46718495
17FLI1_27457419_Chip-Seq_LIVER_Mouse2.40461692
18TAF15_26573619_Chip-Seq_HEK293_Human2.12621068
19E2F4_17652178_ChIP-ChIP_JURKAT_Human2.10373412
20P300_19829295_ChIP-Seq_ESCs_Human2.03803401
21FOXP3_17237761_ChIP-ChIP_TREG_Mouse2.01732449
22ZNF274_21170338_ChIP-Seq_K562_Hela2.00735276
23IGF1R_20145208_ChIP-Seq_DFB_Human2.00730505
24CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.97639082
25* CTBP2_25329375_ChIP-Seq_LNCAP_Human1.94555648
26MYC_22102868_ChIP-Seq_BL_Human1.91729736
27AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.91240900
28KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.89373497
29STAT6_21828071_ChIP-Seq_BEAS2B_Human1.88952359
30AR_21909140_ChIP-Seq_LNCAP_Human1.86436212
31GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.84619410
32TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.83437974
33* EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.79571626
34KDM2B_26808549_Chip-Seq_DND41_Human1.78358842
35ER_23166858_ChIP-Seq_MCF-7_Human1.77443706
36CTBP1_25329375_ChIP-Seq_LNCAP_Human1.77282550
37RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.76657201
38TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.76134229
39BCAT_22108803_ChIP-Seq_LS180_Human1.71959722
40UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.71073288
41SMAD3_21741376_ChIP-Seq_EPCs_Human1.70233816
42PKCTHETA_26484144_Chip-Seq_BREAST_Human1.68659031
43SMAD4_21799915_ChIP-Seq_A2780_Human1.68552047
44FUS_26573619_Chip-Seq_HEK293_Human1.66243627
45SUZ12_27294783_Chip-Seq_NPCs_Mouse1.65119181
46FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.64816449
47FOXO3_23340844_ChIP-Seq_DLD1_Human1.63791591
48VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.63613667
49* CBP_20019798_ChIP-Seq_JUKART_Human1.61752648
50* IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.61752648
51DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.60379509
52SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.59278648
53CDX2_19796622_ChIP-Seq_MESCs_Mouse1.58476886
54EZH2_27294783_Chip-Seq_NPCs_Mouse1.58316674
55PIAS1_25552417_ChIP-Seq_VCAP_Human1.58110553
56PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.57090837
57KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.54841940
58* SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.50216571
59P300_27058665_Chip-Seq_ZR-75-30cells_Human1.49632522
60NR3C1_21868756_ChIP-Seq_MCF10A_Human1.48856968
61AR_25329375_ChIP-Seq_VCAP_Human1.48152506
62NFE2_27457419_Chip-Seq_LIVER_Mouse1.46851579
63FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human1.46393525
64OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.45455815
65CIITA_25753668_ChIP-Seq_RAJI_Human1.45060953
66SMAD_19615063_ChIP-ChIP_OVARY_Human1.44199315
67SOX2_19829295_ChIP-Seq_ESCs_Human1.43418549
68NANOG_19829295_ChIP-Seq_ESCs_Human1.43418549
69EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.42459608
70TCF7_22412390_ChIP-Seq_EML_Mouse1.41851249
71CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.39679856
72CRX_20693478_ChIP-Seq_RETINA_Mouse1.39638446
73SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.38849186
74KDM5A_27292631_Chip-Seq_BREAST_Human1.38646238
75SMAD4_21741376_ChIP-Seq_EPCs_Human1.38569496
76GATA1_22025678_ChIP-Seq_K562_Human1.36320865
77TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.35034215
78TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.34114114
79POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.34114114
80NANOG_18555785_Chip-Seq_ESCs_Mouse1.32166706
81* FLI1_21867929_ChIP-Seq_TH2_Mouse1.31945504
82TOP2B_26459242_ChIP-Seq_MCF-7_Human1.31101801
83CJUN_26792858_Chip-Seq_BT549_Human1.30926489
84ZFP281_27345836_Chip-Seq_ESCs_Mouse1.30894822
85CDX2_22108803_ChIP-Seq_LS180_Human1.30413286
86TCF4_23295773_ChIP-Seq_U87_Human1.30311688
87KDM2B_26808549_Chip-Seq_JURKAT_Human1.30209023
88CTNNB1_20460455_ChIP-Seq_HCT116_Human1.29942667
89RUNX2_22187159_ChIP-Seq_PCA_Human1.29757157
90KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.28835765
91IRF8_22096565_ChIP-ChIP_GC-B_Human1.28708771
92CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.28526084
93PCGF2_27294783_Chip-Seq_NPCs_Mouse1.27634616
94CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.27115108
95KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.26498068
96TCF4_22108803_ChIP-Seq_LS180_Human1.26480732
97MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.26356976
98EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.25718129
99EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.24105052
100YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.23405270
101TP53_16413492_ChIP-PET_HCT116_Human1.22448840
102MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.21359009
103OCT4_21477851_ChIP-Seq_ESCs_Mouse1.21320743
104NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.20777596
105NRF2_20460467_ChIP-Seq_MEFs_Mouse1.20777596
106E2F1_18555785_Chip-Seq_ESCs_Mouse1.18960820
107SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse1.18438369
108IRF8_21731497_ChIP-ChIP_J774_Mouse1.18244789
109SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.17261305
110RUNX1_17652178_ChIP-ChIP_JURKAT_Human1.16821875
111TFEB_21752829_ChIP-Seq_HELA_Human1.16415251
112* CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.15019809
113KDM2B_26808549_Chip-Seq_K562_Human1.14396022
114* TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse1.14169661
115KLF5_20875108_ChIP-Seq_MESCs_Mouse1.13400383
116ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.13121719
117MYB_26560356_Chip-Seq_TH1_Human1.13023091
118PRDM14_20953172_ChIP-Seq_ESCs_Human1.12717758
119P53_22387025_ChIP-Seq_ESCs_Mouse1.12626478
120* VDR_24787735_ChIP-Seq_THP-1_Human1.11179305
121AR_21572438_ChIP-Seq_LNCaP_Human1.10459478
122FOXM1_26456572_ChIP-Seq_MCF-7_Human1.10233717
123CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.09321634
124KDM2B_26808549_Chip-Seq_REH_Human1.09287528
125STAT3_18555785_Chip-Seq_ESCs_Mouse1.08150237
126TAL1_26923725_Chip-Seq_HPCs_Mouse1.07986777
127UTX_26944678_Chip-Seq_JUKART_Human1.07466148
128KDM2B_26808549_Chip-Seq_SUP-B15_Human1.05878864
129CBX2_27304074_Chip-Seq_ESCs_Mouse1.05666907
130SUZ12_18555785_Chip-Seq_ESCs_Mouse1.05147946
131TBX3_20139965_ChIP-Seq_MESCs_Mouse1.04880384
132P300_18555785_Chip-Seq_ESCs_Mouse1.04588243
133TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.04527017
134UBF1/2_26484160_Chip-Seq_HMECs_Human1.04293201
135BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.04168256
136RARB_27405468_Chip-Seq_BRAIN_Mouse1.04011862
137SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.03422035
138* TP53_18474530_ChIP-ChIP_U2OS_Human1.03266945
139TBX3_20139965_ChIP-Seq_ESCs_Mouse1.03040320
140Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.03019286
141FOXA1_21572438_ChIP-Seq_LNCaP_Human1.02906390
142IRF1_19129219_ChIP-ChIP_H3396_Human1.02805889
143CMYC_18555785_Chip-Seq_ESCs_Mouse1.02739257
144EP300_21415370_ChIP-Seq_HL-1_Mouse1.02285027
145SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.02237504
146* PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.02095309
147RXR_22108803_ChIP-Seq_LS180_Human1.01103428
148CHD1_26751641_Chip-Seq_LNCaP_Human1.00957391
149ESR2_21235772_ChIP-Seq_MCF-7_Human1.00785090
150RUNX1_27514584_Chip-Seq_MCF-7_Human1.00782011
151SOX2_21211035_ChIP-Seq_LN229_Gbm1.00618148
152E2F1_21310950_ChIP-Seq_MCF-7_Human1.00039754
153DROSHA_22980978_ChIP-Seq_HELA_Human0.98567206
154PCGF2_27294783_Chip-Seq_ESCs_Mouse0.97976647
155PPAR_26484153_Chip-Seq_NCI-H1993_Human0.97426046
156TBL1_22424771_ChIP-Seq_293T_Human0.96866055
157CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons0.95099492
158MITF_21258399_ChIP-Seq_MELANOMA_Human0.94350083
159NCOR1_26117541_ChIP-Seq_K562_Human0.93831362
160MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse0.93499245
161STAT6_20620947_ChIP-Seq_CD4_POS_T_Human0.92421530
162EOMES_20176728_ChIP-ChIP_TSCs_Mouse0.91037103
163GATA1_26923725_Chip-Seq_HPCs_Mouse0.90626111
164FOXP2_23625967_ChIP-Seq_PFSK-1_AND_SK-N-MC_Human0.89963994
165SMAD1_18555785_ChIP-Seq_MESCs_Mouse0.89836689
166STAT3_20064451_ChIP-Seq_CD4+T_Mouse0.89672422
167MAF_26560356_Chip-Seq_TH1_Human0.88645608
168* VDR_21846776_ChIP-Seq_THP-1_Human0.87391711
169PADI4_21655091_ChIP-ChIP_MCF-7_Human0.86739116
170PRDM5_23873026_ChIP-Seq_MEFs_Mouse0.85788987
171WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse0.84921600
172* ISL1_27105846_Chip-Seq_CPCs_Mouse0.84669622
173FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human0.84246339
174* STAT3_23295773_ChIP-Seq_U87_Human0.81918399
175TFAP2C_20629094_ChIP-Seq_MCF-7_Human0.81572365
176FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human0.81284552
177FOXA1_26743006_Chip-Seq_LNCaP-abl_Human0.80796718
178AHR_22903824_ChIP-Seq_MCF-7_Human0.79224207
179ARNT_22903824_ChIP-Seq_MCF-7_Human0.78551957
180TP63_19390658_ChIP-ChIP_HaCaT_Human0.77674219
181SMAD2_18955504_ChIP-ChIP_HaCaT_Human0.77513611
182SMAD3_18955504_ChIP-ChIP_HaCaT_Human0.77513611
183* GATA6_25053715_ChIP-Seq_YYC3_Human0.77184840
184EWS_26573619_Chip-Seq_HEK293_Human0.76499501
185MYC_19079543_ChIP-ChIP_MESCs_Mouse0.76429278
186POU3F1_26484290_ChIP-Seq_ESCss_Mouse0.75772984
187SREBP2_21459322_ChIP-Seq_LIVER_Mouse0.75535502
188MYCN_18555785_ChIP-Seq_MESCs_Mouse0.74976201
189FOXA1_25552417_ChIP-Seq_VCAP_Human0.74774155
190TCF4_18268006_ChIP-ChIP_LS174T_Human0.74763557

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0000372_irregular_coat_pigmentation5.97993862
2MP0005171_absent_coat_pigmentation5.33186146
3MP0000569_abnormal_digit_pigmentation4.52847233
4MP0003195_calcinosis3.95417741
5MP0003183_abnormal_peptide_metabolism3.71302936
6MP0002163_abnormal_gland_morphology3.64471754
7MP0002877_abnormal_melanocyte_morpholog3.40658566
8MP0003646_muscle_fatigue3.38838144
9MP0005408_hypopigmentation3.30892346
10MP0000015_abnormal_ear_pigmentation3.14955394
11MP0004381_abnormal_hair_follicle3.04150426
12MP0000371_diluted_coat_color2.94228906
13MP0002837_dystrophic_cardiac_calcinosis2.84006512
14MP0005379_endocrine/exocrine_gland_phen2.66098171
15MP0002095_abnormal_skin_pigmentation2.44020906
16MP0003136_yellow_coat_color2.38054576
17MP0006054_spinal_hemorrhage2.33998051
18MP0010307_abnormal_tumor_latency2.25767050
19MP0005167_abnormal_blood-brain_barrier2.22864637
20MP0004215_abnormal_myocardial_fiber2.11419933
21MP0003878_abnormal_ear_physiology2.07546537
22MP0005377_hearing/vestibular/ear_phenot2.07546537
23MP0004885_abnormal_endolymph2.06069236
24MP0005551_abnormal_eye_electrophysiolog2.02393882
25MP0008260_abnormal_autophagy1.98352982
26MP0003111_abnormal_nucleus_morphology1.93178909
27MP0003724_increased_susceptibility_to1.92681101
28MP0010678_abnormal_skin_adnexa1.92556861
29MP0000383_abnormal_hair_follicle1.91915058
30MP0010094_abnormal_chromosome_stability1.90559679
31MP0003123_paternal_imprinting1.88668380
32MP0005174_abnormal_tail_pigmentation1.80075581
33MP0004084_abnormal_cardiac_muscle1.78557929
34MP0010386_abnormal_urinary_bladder1.75512394
35MP0002102_abnormal_ear_morphology1.75324139
36MP0002075_abnormal_coat/hair_pigmentati1.73912143
37MP0006082_CNS_inflammation1.69345585
38MP0001324_abnormal_eye_pigmentation1.67889724
39MP0004510_myositis1.62190973
40MP0009764_decreased_sensitivity_to1.59702047
41MP0003567_abnormal_fetal_cardiomyocyte1.58153783
42MP0004484_altered_response_of1.53148318
43MP0008875_abnormal_xenobiotic_pharmacok1.48122164
44MP0001186_pigmentation_phenotype1.44429807
45MP0005257_abnormal_intraocular_pressure1.42693411
46MP0000733_abnormal_muscle_development1.41379184
47MP0001661_extended_life_span1.40905118
48MP0005253_abnormal_eye_physiology1.37174165
49MP0005410_abnormal_fertilization1.35996516
50MP0000343_altered_response_to1.35962729
51MP0002009_preneoplasia1.35627949
52MP0001984_abnormal_olfaction1.34954952
53MP0002139_abnormal_hepatobiliary_system1.33989841
54MP0003045_fibrosis1.31689238
55MP0001986_abnormal_taste_sensitivity1.30787232
56MP0002277_abnormal_respiratory_mucosa1.30375245
57MP0000749_muscle_degeneration1.29563934
58MP0001968_abnormal_touch/_nociception1.29076721
59MP0001299_abnormal_eye_distance/1.28462299
60MP0000747_muscle_weakness1.28001981
61MP0004043_abnormal_pH_regulation1.27102921
62MP0005058_abnormal_lysosome_morphology1.24363497
63MP0001501_abnormal_sleep_pattern1.23905740
64MP0005409_darkened_coat_color1.21233326
65MP0002736_abnormal_nociception_after1.21171438
66MP0003077_abnormal_cell_cycle1.17998757
67MP0003121_genomic_imprinting1.17744521
68MP0005671_abnormal_response_to1.17439355
69MP0005310_abnormal_salivary_gland1.17026257
70MP0002148_abnormal_hypersensitivity_rea1.16517094
71MP0009046_muscle_twitch1.15308001
72MP0002138_abnormal_hepatobiliary_system1.12466831
73MP0001730_embryonic_growth_arrest1.12445952
74MP0003787_abnormal_imprinting1.12338319
75MP0005647_abnormal_sex_gland1.11852097
76MP0010234_abnormal_vibrissa_follicle1.11316715
77MP0009703_decreased_birth_body1.11213277
78MP0003705_abnormal_hypodermis_morpholog1.10613433
79MP0008877_abnormal_DNA_methylation1.10191268
80MP0002332_abnormal_exercise_endurance1.10081858
81MP0006276_abnormal_autonomic_nervous1.09885634
82MP0000647_abnormal_sebaceous_gland1.09567912
83MP0003950_abnormal_plasma_membrane1.09130633
84MP0001293_anophthalmia1.07812362
85MP0004197_abnormal_fetal_growth/weight/1.07479310
86MP0005248_abnormal_Harderian_gland1.06487528
87MP0005075_abnormal_melanosome_morpholog1.06119026
88MP0004036_abnormal_muscle_relaxation1.05508304
89MP0002972_abnormal_cardiac_muscle1.04903536
90MP0003300_gastrointestinal_ulcer1.04830652
91MP0001486_abnormal_startle_reflex1.03943010
92MP0005620_abnormal_muscle_contractility1.03339429
93MP0003137_abnormal_impulse_conducting1.03325893
94MP0008775_abnormal_heart_ventricle1.03004080
95MP0003633_abnormal_nervous_system1.02686617
96MP0009697_abnormal_copulation1.02556742
97MP0002166_altered_tumor_susceptibility1.02293537
98MP0000920_abnormal_myelination1.02014179
99MP0002229_neurodegeneration0.98951984
100MP0005670_abnormal_white_adipose0.98599383
101MP0001440_abnormal_grooming_behavior0.98487436
102MP0004142_abnormal_muscle_tone0.98252753
103MP0000537_abnormal_urethra_morphology0.97897461
104MP0002396_abnormal_hematopoietic_system0.97851495
105MP0008057_abnormal_DNA_replication0.96846465
106MP0004185_abnormal_adipocyte_glucose0.96429380
107MP0002272_abnormal_nervous_system0.96373460
108MP0009745_abnormal_behavioral_response0.96248380
109MP0003656_abnormal_erythrocyte_physiolo0.95534495
110MP0005076_abnormal_cell_differentiation0.94823720
111MP0004742_abnormal_vestibular_system0.94648265
112MP0002638_abnormal_pupillary_reflex0.94459041
113MP0005646_abnormal_pituitary_gland0.94121289
114MP0009672_abnormal_birth_weight0.93568410
115MP0001849_ear_inflammation0.93410014
116MP0004883_abnormal_blood_vessel0.92837681
117MP0005380_embryogenesis_phenotype0.92818729
118MP0001672_abnormal_embryogenesis/_devel0.92818729
119MP0002092_abnormal_eye_morphology0.92773308
120MP0003011_delayed_dark_adaptation0.92292069
121MP0001756_abnormal_urination0.91115814
122MP0004808_abnormal_hematopoietic_stem0.90104038
123MP0003632_abnormal_nervous_system0.89885682
124MP0003828_pulmonary_edema0.89527100
125MP0002938_white_spotting0.88824689
126MP0003937_abnormal_limbs/digits/tail_de0.88623557
127MP0000230_abnormal_systemic_arterial0.87879212
128MP0005595_abnormal_vascular_smooth0.87304668
129MP0004147_increased_porphyrin_level0.86868153
130MP0003984_embryonic_growth_retardation0.85663508
131MP0008872_abnormal_physiological_respon0.85371278
132MP0008770_decreased_survivor_rate0.84188519
133MP0005623_abnormal_meninges_morphology0.83841189
134MP0002084_abnormal_developmental_patter0.83317883
135MP0000428_abnormal_craniofacial_morphol0.83037125
136MP0000377_abnormal_hair_follicle0.82810086
137MP0002088_abnormal_embryonic_growth/wei0.82738405
138MP0003693_abnormal_embryo_hatching0.82318718
139MP0005197_abnormal_uvea_morphology0.82156051
140MP0000350_abnormal_cell_proliferation0.81802837
141MP0009785_altered_susceptibility_to0.81432147
142MP0003453_abnormal_keratinocyte_physiol0.81026954
143MP0008961_abnormal_basal_metabolism0.79518244
144MP0001970_abnormal_pain_threshold0.78269356
145MP0002067_abnormal_sensory_capabilities0.78238894
146MP0002086_abnormal_extraembryonic_tissu0.77775694
147MP0003172_abnormal_lysosome_physiology0.77161267
148MP0000751_myopathy0.76978609
149MP0001879_abnormal_lymphatic_vessel0.76411993
150MP0004085_abnormal_heartbeat0.76216109
151MP0005423_abnormal_somatic_nervous0.76213618
152MP0004233_abnormal_muscle_weight0.75496041
153MP0006072_abnormal_retinal_apoptosis0.75393350
154MP0000427_abnormal_hair_cycle0.75158760
155MP0005503_abnormal_tendon_morphology0.74542873
156MP0003690_abnormal_glial_cell0.72928348
157MP0000003_abnormal_adipose_tissue0.72884591
158MP0003279_aneurysm0.72426139
159MP0005266_abnormal_metabolism0.72387024
160MP0000026_abnormal_inner_ear0.71872360
161MP0001963_abnormal_hearing_physiology0.70176020
162MP0004947_skin_inflammation0.69044885
163MP0002653_abnormal_ependyma_morphology0.69012507
164MP0002127_abnormal_cardiovascular_syste0.68847305
165MP0001485_abnormal_pinna_reflex0.68709140
166MP0002080_prenatal_lethality0.68204981
167MP0008569_lethality_at_weaning0.67515876
168MP0005164_abnormal_response_to0.67286075
169MP0003631_nervous_system_phenotype0.67272797
170MP0005195_abnormal_posterior_eye0.66874480
171MP0005391_vision/eye_phenotype0.66239563
172MP0004264_abnormal_extraembryonic_tissu0.66161603
173MP0001697_abnormal_embryo_size0.65669019
174MP0000367_abnormal_coat/_hair0.65482561
175MP0002090_abnormal_vision0.65370601
176MP0001188_hyperpigmentation0.65212722
177MP0005187_abnormal_penis_morphology0.64517010
178MP0002177_abnormal_outer_ear0.64334139
179MP0002085_abnormal_embryonic_tissue0.63621926

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of glycolipid metabolism (HP:0010969)6.74486182
2Abnormality of liposaccharide metabolism (HP:0010968)6.74486182
3Abnormality of glycosphingolipid metabolism (HP:0004343)6.74486182
4Overlapping toe (HP:0001845)6.74445477
5Spastic diplegia (HP:0001264)4.76897615
6Aplasia/Hypoplasia of the macula (HP:0008059)4.33390347
7Aplasia/Hypoplasia affecting the retina (HP:0008061)4.28557198
8Blue irides (HP:0000635)4.10099253
9Pancreatic cysts (HP:0001737)3.84900723
10Ocular albinism (HP:0001107)3.84519476
11Absent/shortened dynein arms (HP:0200106)3.63967313
12Dynein arm defect of respiratory motile cilia (HP:0012255)3.63967313
13Hyperacusis (HP:0010780)3.63112232
14True hermaphroditism (HP:0010459)3.62515814
15Pancreatic fibrosis (HP:0100732)3.57705736
16Hypopigmentation of the fundus (HP:0007894)3.50316956
17Overriding aorta (HP:0002623)3.48425353
18Tongue fasciculations (HP:0001308)3.47543256
19Increased cerebral lipofuscin (HP:0011813)3.33397147
20Hyperventilation (HP:0002883)3.30044584
21Aplasia/Hypoplasia of the fovea (HP:0008060)3.29801253
22Hypoplasia of the fovea (HP:0007750)3.29801253
23Increased neuronal autofluorescent lipopigment (HP:0002074)3.26431912
24Vacuolated lymphocytes (HP:0001922)3.25078049
25J-shaped sella turcica (HP:0002680)3.21697300
26Decreased circulating renin level (HP:0003351)3.16152614
27Elfin facies (HP:0004428)3.15298074
28Iris hypopigmentation (HP:0007730)3.12761007
29Nephronophthisis (HP:0000090)3.11691671
30Muscle fibrillation (HP:0010546)3.01941528
31Fair hair (HP:0002286)3.00221782
32Abnormality of vision evoked potentials (HP:0000649)2.89347859
33Abnormality of the antihelix (HP:0009738)2.85198837
34Subacute progressive viral hepatitis (HP:0006572)2.83011539
35Abnormal drinking behavior (HP:0030082)2.82412269
36Polydipsia (HP:0001959)2.82412269
37Carpal bone hypoplasia (HP:0001498)2.81129634
38Renovascular hypertension (HP:0100817)2.80966767
39Clumsiness (HP:0002312)2.80209895
40Insomnia (HP:0100785)2.79278642
41Decreased central vision (HP:0007663)2.78992180
42Macroorchidism (HP:0000053)2.78786166
43Broad ribs (HP:0000885)2.77022959
44Disinhibition (HP:0000734)2.68731916
45Abnormal ciliary motility (HP:0012262)2.66369039
46Inappropriate behavior (HP:0000719)2.64729047
47Abolished electroretinogram (ERG) (HP:0000550)2.64593516
48Ulnar deviation of finger (HP:0009465)2.64138700
49Attenuation of retinal blood vessels (HP:0007843)2.61129020
50Abnormality of the renal medulla (HP:0100957)2.60620752
51Increased nuchal translucency (HP:0010880)2.60491549
52Dysostosis multiplex (HP:0000943)2.60405979
53Abnormal respiratory epithelium morphology (HP:0012253)2.59637985
54Abnormal respiratory motile cilium morphology (HP:0005938)2.59637985
55Abnormality of polysaccharide metabolism (HP:0011012)2.58581599
56Abnormality of glycosaminoglycan metabolism (HP:0004371)2.58581599
57Abnormality of mucopolysaccharide metabolism (HP:0011020)2.58581599
58Cutaneous melanoma (HP:0012056)2.55482775
59Generalized hypopigmentation (HP:0007513)2.54771391
60Molar tooth sign on MRI (HP:0002419)2.53574013
61Abnormality of midbrain morphology (HP:0002418)2.53574013
62Abnormality of the fovea (HP:0000493)2.53330865
63Abnormality of macular pigmentation (HP:0008002)2.51700664
64Mucopolysacchariduria (HP:0008155)2.51317938
65Urinary glycosaminoglycan excretion (HP:0003541)2.51317938
66Sensory axonal neuropathy (HP:0003390)2.50247280
67Aplasia/Hypoplasia of the tongue (HP:0010295)2.48353538
68Heterotopia (HP:0002282)2.46949737
69Congenital hepatic fibrosis (HP:0002612)2.46732889
70Flat cornea (HP:0007720)2.43281740
71Anomalous pulmonary venous return (HP:0010772)2.42516515
72Impulsivity (HP:0100710)2.40261424
73Gaze-evoked nystagmus (HP:0000640)2.33771020
74Abnormality of the renal cortex (HP:0011035)2.33672512
75Abnormal rod and cone electroretinograms (HP:0008323)2.33222173
76Ureteral duplication (HP:0000073)2.33218985
77Medial flaring of the eyebrow (HP:0010747)2.32812020
78Absent rod-and cone-mediated responses on ERG (HP:0007688)2.32265577
79Entropion (HP:0000621)2.31758071
80Syncope (HP:0001279)2.31179625
81Abnormality of the lumbar spine (HP:0100712)2.30072486
82Submucous cleft hard palate (HP:0000176)2.27922645
83Cystic liver disease (HP:0006706)2.27095049
84Oligodactyly (hands) (HP:0001180)2.24606620
85Beaking of vertebral bodies (HP:0004568)2.24571436
86Progressive cerebellar ataxia (HP:0002073)2.24311268
87Adactyly (HP:0009776)2.22181245
88Bowel diverticulosis (HP:0005222)2.18952175
89Abnormality of the fingertips (HP:0001211)2.18260125
90Onion bulb formation (HP:0003383)2.18149773
91Abnormal respiratory motile cilium physiology (HP:0012261)2.18071391
92Hypoplasia of the iris (HP:0007676)2.16358790
93Volvulus (HP:0002580)2.16025798
94Aplasia/Hypoplasia of the tibia (HP:0005772)2.14744208
95Upper limb muscle weakness (HP:0003484)2.13248126
96Congenital stationary night blindness (HP:0007642)2.12658513
97Enlarged penis (HP:0000040)2.12305936
98Abnormality of the pulmonary veins (HP:0011718)2.11193162
99Abnormality of the corticospinal tract (HP:0002492)2.10073223
100Prominent nose (HP:0000448)2.08861577
101Widely spaced teeth (HP:0000687)2.08521924
102Degeneration of the lateral corticospinal tracts (HP:0002314)2.07944885
103Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)2.07944885
104Increased corneal curvature (HP:0100692)2.07446015
105Keratoconus (HP:0000563)2.07446015
106Bony spicule pigmentary retinopathy (HP:0007737)2.06541353
107Broad alveolar ridges (HP:0000187)2.03930450
108Renal duplication (HP:0000075)2.01915488
109Absent speech (HP:0001344)2.01217134
110Polyuria (HP:0000103)2.01089788
111Protuberant abdomen (HP:0001538)2.00183698
112Tubular atrophy (HP:0000092)1.98251028
113Thoracolumbar scoliosis (HP:0002944)1.98241610
114Freckling (HP:0001480)1.97527644
115Abnormal auditory evoked potentials (HP:0006958)1.96984745
116Ulnar deviation of the hand or of fingers of the hand (HP:0001193)1.96511484
117Cheekbone underdevelopment (HP:0010669)1.96510156
118Flared iliac wings (HP:0002869)1.96490777
119Abnormality of the odontoid process (HP:0003310)1.96433870
120Diastasis recti (HP:0001540)1.96051374
121Protruding tongue (HP:0010808)1.95900714
122Hyporeflexia of lower limbs (HP:0002600)1.95789276
123Abnormality of the diencephalon (HP:0010662)1.95407094
124Thoracic kyphosis (HP:0002942)1.95216191
125Agnosia (HP:0010524)1.94953675
126Constricted visual fields (HP:0001133)1.92337386
127Obsessive-compulsive behavior (HP:0000722)1.89131113
128Renal cortical cysts (HP:0000803)1.87331094
129Autoimmune thrombocytopenia (HP:0001973)1.84807965
130Macroglossia (HP:0000158)1.83474222
131Albinism (HP:0001022)1.83398051
132Congenital primary aphakia (HP:0007707)1.83085593
133Macular degeneration (HP:0000608)1.83022977
134Aortic regurgitation (HP:0001659)1.82396700
135Generalized hypopigmentation of hair (HP:0011358)1.82260466
136Impaired smooth pursuit (HP:0007772)1.81599951
137Chronic hepatic failure (HP:0100626)1.81096359
138Deformed sella turcica (HP:0002681)1.80721894
139Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)1.80708711
140Hemiplegia (HP:0002301)1.79744906
141Facial hemangioma (HP:0000329)1.78980339
142T lymphocytopenia (HP:0005403)1.77935104
143Anencephaly (HP:0002323)1.76212842
144Spastic paraplegia (HP:0001258)1.76083994
145Vertebral arch anomaly (HP:0008438)1.75954359
146Decreased electroretinogram (ERG) amplitude (HP:0000654)1.75910071
147Aplasia/Hypoplasia involving the carpal bones (HP:0006502)1.75883286
148Portal hypertension (HP:0001409)1.73874878
149Macrotia (HP:0000400)1.73848016
150Spastic gait (HP:0002064)1.73748361
151Gait imbalance (HP:0002141)1.73607599
152Astrocytoma (HP:0009592)1.71894368
153Abnormality of the astrocytes (HP:0100707)1.71894368
154Pointed chin (HP:0000307)1.70938869
155Distal lower limb amyotrophy (HP:0008944)1.69392129
156Decreased number of peripheral myelinated nerve fibers (HP:0003380)1.69243398
157Hypotelorism (HP:0000601)1.68824506
158Abnormality of the carotid arteries (HP:0005344)1.68436367
159Distal upper limb amyotrophy (HP:0007149)1.67996094
160Upper limb amyotrophy (HP:0009129)1.67996094
161Cafe-au-lait spot (HP:0000957)1.67089219
162Urinary urgency (HP:0000012)1.66729070
163Ectopic kidney (HP:0000086)1.66288669
164Genetic anticipation (HP:0003743)1.64215505
165Cerebral aneurysm (HP:0004944)1.63777676
166Open mouth (HP:0000194)1.63606798
167Proximal placement of thumb (HP:0009623)1.62027059
168Congenital sensorineural hearing impairment (HP:0008527)1.59801175
169Truncal ataxia (HP:0002078)1.59438923
170Basal cell carcinoma (HP:0002671)1.58904409
171Abnormality of the umbilical cord (HP:0010881)1.58239097
172Urinary bladder sphincter dysfunction (HP:0002839)1.57520523
173Insidious onset (HP:0003587)1.56338811
174Termporal pattern (HP:0011008)1.56338811
175Lower limb amyotrophy (HP:0007210)1.56337366
176Viral hepatitis (HP:0006562)1.54753593
177Bladder diverticulum (HP:0000015)1.54704228
178Everted lower lip vermilion (HP:0000232)1.54516702
179Distal sensory impairment (HP:0002936)1.53650879
180Curly hair (HP:0002212)1.53342946
181Low posterior hairline (HP:0002162)1.52399494
182Narrow palate (HP:0000189)1.51697847
183Decreased motor nerve conduction velocity (HP:0003431)1.50163094
184Furrowed tongue (HP:0000221)1.49810496
185Prostate neoplasm (HP:0100787)1.49723957
186Megalocornea (HP:0000485)1.48972076
187Abnormality of T cell number (HP:0011839)1.47877940
188Slow saccadic eye movements (HP:0000514)1.47179486
189Glioma (HP:0009733)1.47133044
190Elevated circulating parathyroid hormone (PTH) level (HP:0003165)1.46475416
191Abnormality of the labia minora (HP:0012880)1.46455042
192Hand muscle atrophy (HP:0009130)1.46184063

Predicted kinase interactions (KEA)

RankGene SetZ-score
1FRK6.74087347
2BLK5.37422687
3MST1R4.32504845
4PNCK4.20682320
5INSRR3.29088414
6ACVR1B2.89740158
7WEE12.87957871
8MET2.74814361
9ADRBK22.52844305
10ALK2.32900556
11TSSK62.29721496
12CDK122.25185896
13GRK72.24334389
14EEF2K2.23926240
15MARK32.18668235
16BRD42.13428845
17WNK32.12352832
18TGFBR22.10955601
19BMPR1B2.05090124
20PKN21.99238997
21TNIK1.95154048
22CAMK1G1.92698513
23TAOK31.87933299
24FGFR21.80242688
25TRIB31.80121351
26GRK11.73169000
27NEK21.68028152
28PINK11.66494023
29MAP4K21.64967998
30CAMKK21.63238351
31MAP3K91.62346687
32PDGFRB1.60087811
33STK38L1.59729026
34LATS11.59395319
35CAMK1D1.55112413
36MAP3K41.49744110
37WNK11.49393709
38OBSCN1.47978050
39MKNK21.46573116
40BMX1.43429342
41CSNK1A1L1.37847863
42PAK31.33358123
43MUSK1.32950688
44TXK1.31477107
45EPHB11.25815181
46TIE11.23904813
47STK391.23801854
48MTOR1.22268331
49MYLK1.20563554
50MKNK11.20486738
51CDK61.16285105
52ICK1.13978259
53TTN1.13303241
54STK31.05166650
55PTK61.02489813
56CAMK41.01027926
57TYRO30.98484537
58SGK30.98088858
59TLK10.96954566
60ADRBK10.95859855
61PDGFRA0.95780831
62CDC70.95224092
63MATK0.95063910
64PTK2B0.94492580
65FGFR40.94473941
66AKT30.92424220
67PLK30.91972114
68PTK20.89958607
69RET0.87749303
70MAP2K70.87621249
71ITK0.86645041
72NTRK10.85213580
73PLK20.84856653
74CHEK10.81380549
75IRAK10.81105261
76ZAK0.80411256
77DYRK30.80177535
78CSNK1G10.80046102
79SYK0.79133388
80SGK4940.77859921
81SGK2230.77859921
82FGFR10.77843096
83PDK20.77793685
84GRK50.77525482
85JAK10.75448553
86TGFBR10.75435620
87SRPK10.75172788
88OXSR10.75094842
89STK40.75018258
90IKBKB0.73634807
91ERBB30.73344010
92CSNK1G30.73079875
93PRKCE0.72211903
94PASK0.72050717
95MARK20.71770601
96MELK0.71561108
97SGK20.70942999
98CHEK20.70592695
99PAK60.69270151
100PIK3CG0.69026251
101MAPK130.69021649
102TTK0.68914749
103DDR20.68806228
104CSNK1E0.67833909
105MAPK100.66395909
106CSNK1G20.64619840
107SIK10.64222377
108STK110.63863036
109IRAK40.63454518
110CSNK1D0.62801951
111CAMK2A0.62754417
112GSK3A0.61643008
113MAP4K10.61083224
114BCR0.60890825
115NUAK10.60421317
116TEC0.59794126
117ATM0.59434260
118EPHA30.59312549
119TRPM70.59041072
120RIPK10.58602910
121CDK20.58398630
122FER0.58238676
123MAP3K130.58112290
124FGFR30.56926417
125PRKAA20.56819199
126SGK10.56716111
127HCK0.56530206
128PDK30.56355273
129PDK40.56355273
130NTRK30.56115325
131CDK10.55979980
132ABL20.55611844
133NEK90.55562443
134MAP3K50.53794043
135MAPK80.53759100
136ZAP700.53680838
137STK240.53678321
138PDK10.53667822
139TNK20.53504038
140RPS6KA60.52902922
141SIK20.52738132
142ATR0.52213796
143STK100.51373369
144MAP3K30.51359514
145MAPK150.51036086
146DAPK20.50417133
147CDK70.50377017
148IKBKE0.50300111
149PRKG10.47558380
150CAMK10.47331767
151PLK10.47047457
152PRKDC0.46910382
153CAMK2D0.46420305
154LYN0.46401214
155CDK40.46321765
156WNK40.45704515
157AURKB0.44926851
158INSR0.44908873
159TYK20.44859513
160NEK10.44580371
161PRKAA10.44520893
162PLK40.44500778
163PHKG20.44419543
164PHKG10.44419543
165PDPK10.44308229
166MAP3K80.43474336
167GSK3B0.43117160
168ABL10.42720461
169PKN10.41944606
170TRIM280.41629217
171MAPK70.40304130
172IRAK20.40213909
173PRKACA0.39993285
174CHUK0.38656116
175MAP2K60.38032782
176BRSK20.37202678
177ERBB20.37091591
178FGR0.36475586
179PRKCG0.36264949
180EGFR0.36048148
181MAP2K40.35686542
182CSK0.33937825
183CASK0.33915831
184IGF1R0.32899740

Predicted pathways (KEGG)

RankGene SetZ-score
1Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006033.63076732
2Vitamin B6 metabolism_Homo sapiens_hsa007502.99412378
3Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006042.67532999
4Dorso-ventral axis formation_Homo sapiens_hsa043202.40075638
5Taurine and hypotaurine metabolism_Homo sapiens_hsa004302.31309475
6Primary bile acid biosynthesis_Homo sapiens_hsa001202.11638119
7Staphylococcus aureus infection_Homo sapiens_hsa051502.10150798
8Renal cell carcinoma_Homo sapiens_hsa052112.03459004
9mTOR signaling pathway_Homo sapiens_hsa041502.03293487
10Collecting duct acid secretion_Homo sapiens_hsa049661.93068123
11Linoleic acid metabolism_Homo sapiens_hsa005911.91358887
12alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.90211703
13Nicotine addiction_Homo sapiens_hsa050331.89902276
14Rheumatoid arthritis_Homo sapiens_hsa053231.88088080
15Glycosaminoglycan degradation_Homo sapiens_hsa005311.77426539
16Progesterone-mediated oocyte maturation_Homo sapiens_hsa049141.76659453
17Phosphatidylinositol signaling system_Homo sapiens_hsa040701.73138707
18Tryptophan metabolism_Homo sapiens_hsa003801.71174195
19Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.71044011
20Chronic myeloid leukemia_Homo sapiens_hsa052201.66542593
21Phototransduction_Homo sapiens_hsa047441.65166121
22Ovarian steroidogenesis_Homo sapiens_hsa049131.58743566
23Taste transduction_Homo sapiens_hsa047421.57006954
24Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.56668030
25Selenocompound metabolism_Homo sapiens_hsa004501.56387110
26Morphine addiction_Homo sapiens_hsa050321.55048465
27Inositol phosphate metabolism_Homo sapiens_hsa005621.54092543
28ABC transporters_Homo sapiens_hsa020101.52671057
29Olfactory transduction_Homo sapiens_hsa047401.52464135
30Arachidonic acid metabolism_Homo sapiens_hsa005901.48963844
31Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.45663907
32Lysine degradation_Homo sapiens_hsa003101.45173233
33T cell receptor signaling pathway_Homo sapiens_hsa046601.43566170
34MicroRNAs in cancer_Homo sapiens_hsa052061.41833661
35Prostate cancer_Homo sapiens_hsa052151.37119950
36Intestinal immune network for IgA production_Homo sapiens_hsa046721.36814213
37RNA transport_Homo sapiens_hsa030131.34894381
38Steroid hormone biosynthesis_Homo sapiens_hsa001401.33485938
39mRNA surveillance pathway_Homo sapiens_hsa030151.29833297
40Type II diabetes mellitus_Homo sapiens_hsa049301.29597301
41Non-small cell lung cancer_Homo sapiens_hsa052231.26724368
42Renin secretion_Homo sapiens_hsa049241.24501303
43Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.24293843
44Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.23299495
45Central carbon metabolism in cancer_Homo sapiens_hsa052301.22721263
46Asthma_Homo sapiens_hsa053101.22361348
47Estrogen signaling pathway_Homo sapiens_hsa049151.22232862
48GABAergic synapse_Homo sapiens_hsa047271.19917636
49Oxidative phosphorylation_Homo sapiens_hsa001901.19298088
50ErbB signaling pathway_Homo sapiens_hsa040121.15740876
51Glycerophospholipid metabolism_Homo sapiens_hsa005641.14976730
52Regulation of autophagy_Homo sapiens_hsa041401.14711458
53Endometrial cancer_Homo sapiens_hsa052131.13476491
54Chemical carcinogenesis_Homo sapiens_hsa052041.09864314
55Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.09592616
56Glioma_Homo sapiens_hsa052141.06885652
57Tuberculosis_Homo sapiens_hsa051521.06618398
58Regulation of lipolysis in adipocytes_Homo sapiens_hsa049231.06550449
59Phospholipase D signaling pathway_Homo sapiens_hsa040721.05486774
60Calcium signaling pathway_Homo sapiens_hsa040201.05275297
61Oocyte meiosis_Homo sapiens_hsa041141.04933190
62Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.03973015
63Fatty acid biosynthesis_Homo sapiens_hsa000611.03830922
64Small cell lung cancer_Homo sapiens_hsa052221.03766461
65Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.03735265
66Butanoate metabolism_Homo sapiens_hsa006501.03120015
67Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054101.03013052
68Viral carcinogenesis_Homo sapiens_hsa052031.02802259
69Phagosome_Homo sapiens_hsa041451.02775191
70Dilated cardiomyopathy_Homo sapiens_hsa054141.01512684
71Choline metabolism in cancer_Homo sapiens_hsa052311.01443315
72FoxO signaling pathway_Homo sapiens_hsa040681.01432125
73Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.01419877
74Cell cycle_Homo sapiens_hsa041101.01320581
75Melanogenesis_Homo sapiens_hsa049161.01232683
76Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.00790662
77Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.00724691
78Longevity regulating pathway - mammal_Homo sapiens_hsa042111.00628960
79Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.00127152
80Circadian entrainment_Homo sapiens_hsa047131.00059257
81Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.00018311
82Carbohydrate digestion and absorption_Homo sapiens_hsa049730.99911167
83Malaria_Homo sapiens_hsa051440.99537910
84Steroid biosynthesis_Homo sapiens_hsa001000.97577540
85Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.96161145
86Serotonergic synapse_Homo sapiens_hsa047260.95433120
87Thyroid hormone signaling pathway_Homo sapiens_hsa049190.95381441
88Tyrosine metabolism_Homo sapiens_hsa003500.94988141
89Mineral absorption_Homo sapiens_hsa049780.89998184
90Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.88564827
91Leishmaniasis_Homo sapiens_hsa051400.87396829
92AMPK signaling pathway_Homo sapiens_hsa041520.87219806
93Proteoglycans in cancer_Homo sapiens_hsa052050.87018866
94Glutathione metabolism_Homo sapiens_hsa004800.85385216
95Cardiac muscle contraction_Homo sapiens_hsa042600.84558201
96Pancreatic cancer_Homo sapiens_hsa052120.84529810
97Fatty acid elongation_Homo sapiens_hsa000620.83161636
98Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.82342896
99Long-term depression_Homo sapiens_hsa047300.81819514
100Systemic lupus erythematosus_Homo sapiens_hsa053220.81206000
101Cyanoamino acid metabolism_Homo sapiens_hsa004600.80352803
102Neurotrophin signaling pathway_Homo sapiens_hsa047220.80163212
103Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.79284425
104Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.78293561
105Endocytosis_Homo sapiens_hsa041440.78144555
106Other glycan degradation_Homo sapiens_hsa005110.78022654
107Alcoholism_Homo sapiens_hsa050340.77379747
108Prolactin signaling pathway_Homo sapiens_hsa049170.77260623
109Retinol metabolism_Homo sapiens_hsa008300.77102258
110B cell receptor signaling pathway_Homo sapiens_hsa046620.76231312
111Caffeine metabolism_Homo sapiens_hsa002320.75776001
112Vascular smooth muscle contraction_Homo sapiens_hsa042700.75621436
113Graft-versus-host disease_Homo sapiens_hsa053320.74568845
114Complement and coagulation cascades_Homo sapiens_hsa046100.74496925
115MAPK signaling pathway_Homo sapiens_hsa040100.73941916
116Colorectal cancer_Homo sapiens_hsa052100.72101127
117Axon guidance_Homo sapiens_hsa043600.71645170
118NF-kappa B signaling pathway_Homo sapiens_hsa040640.71267427
119Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.70787550
120Insulin signaling pathway_Homo sapiens_hsa049100.70027899
121Sphingolipid metabolism_Homo sapiens_hsa006000.69746387
122Primary immunodeficiency_Homo sapiens_hsa053400.69187744
123PPAR signaling pathway_Homo sapiens_hsa033200.68576933
124Non-homologous end-joining_Homo sapiens_hsa034500.67238656
125Ether lipid metabolism_Homo sapiens_hsa005650.67220249
126VEGF signaling pathway_Homo sapiens_hsa043700.67123846
127Insulin secretion_Homo sapiens_hsa049110.66367495
128Allograft rejection_Homo sapiens_hsa053300.66162085
129p53 signaling pathway_Homo sapiens_hsa041150.65493490
130Long-term potentiation_Homo sapiens_hsa047200.64735122
131Glycerolipid metabolism_Homo sapiens_hsa005610.64252503
132Acute myeloid leukemia_Homo sapiens_hsa052210.63539468
133cAMP signaling pathway_Homo sapiens_hsa040240.62506756
134HIF-1 signaling pathway_Homo sapiens_hsa040660.62292616
135Sphingolipid signaling pathway_Homo sapiens_hsa040710.62261261
136Parkinsons disease_Homo sapiens_hsa050120.62113062
137Melanoma_Homo sapiens_hsa052180.60995197
138Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.60596726
139Insulin resistance_Homo sapiens_hsa049310.59367989
140Alzheimers disease_Homo sapiens_hsa050100.59042666
141Pathways in cancer_Homo sapiens_hsa052000.58961142
142NOD-like receptor signaling pathway_Homo sapiens_hsa046210.58950211
143Nitrogen metabolism_Homo sapiens_hsa009100.58881423
144Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.57358232
145Pentose phosphate pathway_Homo sapiens_hsa000300.57266730
146Fanconi anemia pathway_Homo sapiens_hsa034600.57086301
147Antigen processing and presentation_Homo sapiens_hsa046120.56839187
148GnRH signaling pathway_Homo sapiens_hsa049120.56216467
149Chemokine signaling pathway_Homo sapiens_hsa040620.55837309
150Rap1 signaling pathway_Homo sapiens_hsa040150.54870782
151Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.54598942
152Peroxisome_Homo sapiens_hsa041460.54550297
153HTLV-I infection_Homo sapiens_hsa051660.54509939
154Gastric acid secretion_Homo sapiens_hsa049710.54284329
155Circadian rhythm_Homo sapiens_hsa047100.54251426
156Adherens junction_Homo sapiens_hsa045200.54066166
157Osteoclast differentiation_Homo sapiens_hsa043800.53810057
158Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.53306627
159Tight junction_Homo sapiens_hsa045300.53160396
160Ras signaling pathway_Homo sapiens_hsa040140.52956215
161Lysosome_Homo sapiens_hsa041420.52763787
162Glutamatergic synapse_Homo sapiens_hsa047240.52463677
163Focal adhesion_Homo sapiens_hsa045100.52420495
164Salivary secretion_Homo sapiens_hsa049700.52420235
165Propanoate metabolism_Homo sapiens_hsa006400.51167481
166Platelet activation_Homo sapiens_hsa046110.50621255
167Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.50456457
168Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.50358564
169Hepatitis B_Homo sapiens_hsa051610.50346691
170Maturity onset diabetes of the young_Homo sapiens_hsa049500.50184749
171Cholinergic synapse_Homo sapiens_hsa047250.50047371
172Regulation of actin cytoskeleton_Homo sapiens_hsa048100.49506368
173Epstein-Barr virus infection_Homo sapiens_hsa051690.49458958
174Autoimmune thyroid disease_Homo sapiens_hsa053200.49272042
175Toll-like receptor signaling pathway_Homo sapiens_hsa046200.48437681
176Oxytocin signaling pathway_Homo sapiens_hsa049210.48388862
177Cocaine addiction_Homo sapiens_hsa050300.47688434
178Hematopoietic cell lineage_Homo sapiens_hsa046400.47635403
179Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.47355084
180Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.46518601
181Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.43669217
182Huntingtons disease_Homo sapiens_hsa050160.43138904
183TNF signaling pathway_Homo sapiens_hsa046680.42755686
184Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.40931017
185Starch and sucrose metabolism_Homo sapiens_hsa005000.40410095
186cGMP-PKG signaling pathway_Homo sapiens_hsa040220.39652849
187Pentose and glucuronate interconversions_Homo sapiens_hsa000400.39633240

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