SLC38A7

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1acrosome reaction (GO:0007340)5.85898371
2response to pheromone (GO:0019236)5.78166290
3sperm motility (GO:0030317)5.48683932
4fusion of sperm to egg plasma membrane (GO:0007342)5.19209692
5protein polyglutamylation (GO:0018095)4.54458977
6triglyceride-rich lipoprotein particle remodeling (GO:0034370)4.48068438
7low-density lipoprotein particle clearance (GO:0034383)4.46765343
8plasma membrane fusion (GO:0045026)4.23654715
9single strand break repair (GO:0000012)4.22139905
10plasma lipoprotein particle clearance (GO:0034381)4.20572315
11alpha-linolenic acid metabolic process (GO:0036109)4.17464067
12protein carboxylation (GO:0018214)4.09344664
13peptidyl-glutamic acid carboxylation (GO:0017187)4.09344664
14rRNA methylation (GO:0031167)4.06213782
15regulation of cholesterol homeostasis (GO:2000188)4.05189090
16multicellular organism reproduction (GO:0032504)3.97488409
17negative regulation of fibrinolysis (GO:0051918)3.95922886
18spermatid development (GO:0007286)3.95888543
19erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)3.93465417
20L-phenylalanine metabolic process (GO:0006558)3.93465417
21regulation of cholesterol storage (GO:0010885)3.91840762
22urea cycle (GO:0000050)3.89943895
23urea metabolic process (GO:0019627)3.89943895
24negative regulation of telomere maintenance (GO:0032205)3.87680298
25high-density lipoprotein particle remodeling (GO:0034375)3.78859967
26response to acidic pH (GO:0010447)3.77651576
27regulation of protein activation cascade (GO:2000257)3.72771630
28erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)3.71213653
29L-phenylalanine catabolic process (GO:0006559)3.71213653
30negative regulation of cholesterol transport (GO:0032375)3.61246475
31negative regulation of sterol transport (GO:0032372)3.61246475
32calcium ion-dependent exocytosis (GO:0017156)3.61151104
33dicarboxylic acid biosynthetic process (GO:0043650)3.60199580
34rRNA modification (GO:0000154)3.58729374
35phospholipid homeostasis (GO:0055091)3.58393054
36kynurenine metabolic process (GO:0070189)3.58111893
37regulation of complement activation (GO:0030449)3.57889651
38glycine metabolic process (GO:0006544)3.57250230
39cellular ketone body metabolic process (GO:0046950)3.55802599
40platelet dense granule organization (GO:0060155)3.54760652
41sperm-egg recognition (GO:0035036)3.54735349
42sulfur amino acid catabolic process (GO:0000098)3.51753463
43macroautophagy (GO:0016236)3.49398576
44regulation of vascular endothelial growth factor signaling pathway (GO:1900746)3.49335232
45apoptotic cell clearance (GO:0043277)3.49325158
46complement activation, alternative pathway (GO:0006957)3.48447406
47reverse cholesterol transport (GO:0043691)3.47056674
48nitrogen cycle metabolic process (GO:0071941)3.43347773
49serine family amino acid catabolic process (GO:0009071)3.40118610
50lysine metabolic process (GO:0006553)3.38538058
51lysine catabolic process (GO:0006554)3.38538058
52cellular modified amino acid catabolic process (GO:0042219)3.37543250
53microtubule severing (GO:0051013)3.36251003
54fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)3.34683496
55* L-alpha-amino acid transmembrane transport (GO:1902475)3.34542512
56cysteine metabolic process (GO:0006534)3.32795523
57behavioral response to nicotine (GO:0035095)3.32316798
58cholesterol efflux (GO:0033344)3.32296120
59glyoxylate metabolic process (GO:0046487)3.31241797
60aromatic amino acid family catabolic process (GO:0009074)3.29679007
61phosphatidylethanolamine biosynthetic process (GO:0006646)3.28214900
62cellular response to pH (GO:0071467)3.25075330
63regulation of fibrinolysis (GO:0051917)3.24594164
64homocysteine metabolic process (GO:0050667)3.23358215
65mannose metabolic process (GO:0006013)3.23174275
66reproduction (GO:0000003)3.23138686
67regulation of cilium movement (GO:0003352)3.21217448
68phosphatidylethanolamine metabolic process (GO:0046337)3.20787223
69bile acid biosynthetic process (GO:0006699)3.20656089
70positive regulation by symbiont of host defense response (GO:0052509)3.19481178
71modulation by symbiont of host defense response (GO:0052031)3.19481178
72modulation by organism of immune response of other organism involved in symbiotic interaction (GO:003.19481178
73modulation by organism of defense response of other organism involved in symbiotic interaction (GO:03.19481178
74positive regulation by organism of defense response of other organism involved in symbiotic interact3.19481178
75modulation by symbiont of host immune response (GO:0052553)3.19481178
76ketone body metabolic process (GO:1902224)3.18479795
77protein-lipid complex assembly (GO:0065005)3.17957826
78mannosylation (GO:0097502)3.16568374
79phospholipid efflux (GO:0033700)3.15635082
80plasma lipoprotein particle assembly (GO:0034377)3.11025189
81plasma lipoprotein particle remodeling (GO:0034369)3.08517958
82protein-lipid complex remodeling (GO:0034368)3.08517958
83macromolecular complex remodeling (GO:0034367)3.08517958
844-hydroxyproline metabolic process (GO:0019471)3.07011582
85regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)3.06264613
86negative regulation of Rho protein signal transduction (GO:0035024)3.05670811
87cellular biogenic amine catabolic process (GO:0042402)3.02648836
88amine catabolic process (GO:0009310)3.02648836
89response to pH (GO:0009268)3.00957203
90coenzyme catabolic process (GO:0009109)3.00025565
91regulation of fatty acid beta-oxidation (GO:0031998)2.98546126
92glycerophospholipid catabolic process (GO:0046475)2.97340816
93amino-acid betaine metabolic process (GO:0006577)2.96635526
94regulation of microtubule-based movement (GO:0060632)2.96444336
95positive regulation of lipid catabolic process (GO:0050996)2.95721427
96regulation of cholesterol esterification (GO:0010872)2.94370277
97N-acetylneuraminate metabolic process (GO:0006054)2.93722123
98tryptophan catabolic process (GO:0006569)2.93605369
99indole-containing compound catabolic process (GO:0042436)2.93605369
100indolalkylamine catabolic process (GO:0046218)2.93605369
101pyrimidine nucleobase catabolic process (GO:0006208)2.93206979
102positive regulation of lipid storage (GO:0010884)2.91439844
103acylglycerol homeostasis (GO:0055090)2.91250505
104triglyceride homeostasis (GO:0070328)2.91250505
105serine family amino acid metabolic process (GO:0009069)2.90383284
106tryptophan metabolic process (GO:0006568)2.90025921
107lipoprotein metabolic process (GO:0042157)2.89115566
108positive regulation of SMAD protein import into nucleus (GO:0060391)2.88844532
109folic acid metabolic process (GO:0046655)2.88273515
110lytic vacuole organization (GO:0080171)2.87505631
111lysosome organization (GO:0007040)2.87505631
112bile acid metabolic process (GO:0008206)2.86657604
113positive regulation of membrane protein ectodomain proteolysis (GO:0051044)2.85697098
114negative regulation of fatty acid biosynthetic process (GO:0045717)2.85225266
115serine family amino acid biosynthetic process (GO:0009070)2.85212285
116regulation of translational fidelity (GO:0006450)2.81793771
117amino sugar catabolic process (GO:0046348)2.81714420
118regulation of triglyceride catabolic process (GO:0010896)2.78820214
119negative regulation of lipid transport (GO:0032369)2.78055376
120glutamate metabolic process (GO:0006536)2.76996399
121binding of sperm to zona pellucida (GO:0007339)2.76598715
122ATP hydrolysis coupled proton transport (GO:0015991)2.76316770
123energy coupled proton transmembrane transport, against electrochemical gradient (GO:0015988)2.76316770
124cofactor catabolic process (GO:0051187)2.75952616
125positive regulation of fatty acid oxidation (GO:0046321)2.75824960
126basement membrane organization (GO:0071711)2.74468225
1272-oxoglutarate metabolic process (GO:0006103)2.74399789
128sperm capacitation (GO:0048240)2.73929640
129positive regulation of fatty acid beta-oxidation (GO:0032000)2.73006993
130protein-cofactor linkage (GO:0018065)2.72601828
131regulation of NFAT protein import into nucleus (GO:0051532)2.72346082
132macrophage activation involved in immune response (GO:0002281)2.71958727
133fibrinolysis (GO:0042730)2.71856244
134negative regulation of cell size (GO:0045792)2.70851874
135cholesterol homeostasis (GO:0042632)2.70835121
136sterol homeostasis (GO:0055092)2.70724533
137protein localization to cilium (GO:0061512)2.70077262
138NAD biosynthetic process (GO:0009435)2.68679246
139cell-cell recognition (GO:0009988)2.67796298
140alpha-amino acid catabolic process (GO:1901606)2.67749231
141seminiferous tubule development (GO:0072520)2.67659113
142protein-lipid complex subunit organization (GO:0071825)2.67614440
143cell junction maintenance (GO:0034331)2.67172338
144gamma-aminobutyric acid transport (GO:0015812)2.65829044
145regulation of early endosome to late endosome transport (GO:2000641)2.65696013
146positive regulation of triglyceride metabolic process (GO:0090208)2.64433050
147positive regulation of triglyceride biosynthetic process (GO:0010867)2.64262452
148one-carbon metabolic process (GO:0006730)2.63904173
149positive regulation of action potential (GO:0045760)2.63208159
150positive regulation of prostaglandin secretion (GO:0032308)2.62449738
151spermatogenesis (GO:0007283)2.61100195
152male gamete generation (GO:0048232)2.60545480
153plasma lipoprotein particle organization (GO:0071827)2.60317579
154organic cation transport (GO:0015695)2.60222256
155nucleoside transmembrane transport (GO:1901642)2.57439964
156water-soluble vitamin biosynthetic process (GO:0042364)2.57437919
157positive regulation of mitochondrial fission (GO:0090141)2.56715653
158G-protein coupled glutamate receptor signaling pathway (GO:0007216)2.56315373
159cellular response to ATP (GO:0071318)2.54714920
160single fertilization (GO:0007338)2.52815626
161* alanine transport (GO:0032328)2.51795472
162L-serine metabolic process (GO:0006563)2.49011637
163epithelial cilium movement (GO:0003351)2.48347837
164regulation of telomere maintenance (GO:0032204)2.47544741
165peptidyl-glutamic acid modification (GO:0018200)2.44284689
166positive regulation of Rab GTPase activity (GO:0032851)2.44170904
167regulation of Rab GTPase activity (GO:0032313)2.44170904
168C-terminal protein lipidation (GO:0006501)2.44078530
169lymphangiogenesis (GO:0001946)2.43562562
170short-term memory (GO:0007614)2.43125925
171ubiquinone metabolic process (GO:0006743)2.43116008
172nephron tubule morphogenesis (GO:0072078)2.42360696
173nephron epithelium morphogenesis (GO:0072088)2.42360696
174tooth mineralization (GO:0034505)2.41888147
175axoneme assembly (GO:0035082)2.41639352
176protein localization to Golgi apparatus (GO:0034067)2.41495386
177negative regulation of synaptic transmission, GABAergic (GO:0032229)2.40750619
178intracellular pH reduction (GO:0051452)2.40391801
179cartilage development involved in endochondral bone morphogenesis (GO:0060351)2.39718680
180gamete generation (GO:0007276)2.39266983
181establishment of protein localization to Golgi (GO:0072600)2.38603070
182arginine catabolic process (GO:0006527)2.38326795
183negative regulation of mast cell activation (GO:0033004)2.36653897
184polyamine biosynthetic process (GO:0006596)2.33616164
185proline transport (GO:0015824)2.31613737
186protein targeting to Golgi (GO:0000042)2.29573833
187* basic amino acid transport (GO:0015802)2.29248115
188aspartate family amino acid catabolic process (GO:0009068)2.29207355
189ubiquinone biosynthetic process (GO:0006744)2.28829232
190multicellular organismal movement (GO:0050879)2.28416940
191musculoskeletal movement (GO:0050881)2.28416940
192indolalkylamine metabolic process (GO:0006586)2.26790389

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1ESR1_17901129_ChIP-ChIP_LIVER_Mouse5.58505507
2* RXR_22158963_ChIP-Seq_LIVER_Mouse3.97857486
3ZNF274_21170338_ChIP-Seq_K562_Hela3.86427966
4PPARA_22158963_ChIP-Seq_LIVER_Mouse3.70556015
5NR4A2_19515692_ChIP-ChIP_MN9D_Mouse3.44354165
6TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse3.11639346
7PPARG_19300518_ChIP-PET_3T3-L1_Mouse3.10016444
8NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse3.03184375
9* LXR_22158963_ChIP-Seq_LIVER_Mouse3.00641639
10EGR1_19374776_ChIP-ChIP_THP-1_Human2.72042186
11POU5F1_18700969_ChIP-ChIP_MESCs_Mouse2.47420493
12FOXO1_23066095_ChIP-Seq_LIVER_Mouse2.34728952
13STAT6_21828071_ChIP-Seq_BEAS2B_Human2.28955552
14RARG_19884340_ChIP-ChIP_MEFs_Mouse2.26324307
15GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.16298976
16NR1I2_20693526_ChIP-Seq_LIVER_Mouse2.15170301
17NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human2.08766832
18STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse2.08608370
19NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.05738494
20LXR_22292898_ChIP-Seq_THP-1_Human2.05225240
21GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.98044503
22CLOCK_20551151_ChIP-Seq_293T_Human1.96826876
23MYC_22102868_ChIP-Seq_BL_Human1.96548308
24ELK3_25401928_ChIP-Seq_HUVEC_Human1.90525639
25STAT3_1855785_ChIP-Seq_MESCs_Mouse1.87630185
26NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.85111588
27ERA_21632823_ChIP-Seq_H3396_Human1.82439064
28ZNF263_19887448_ChIP-Seq_K562_Human1.81449207
29GBX2_23144817_ChIP-Seq_PC3_Human1.79145814
30SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.78763235
31CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.78570471
32THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.78270592
33EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.73838656
34IRF8_21731497_ChIP-ChIP_J774_Mouse1.73584228
35CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.72764426
36VDR_22108803_ChIP-Seq_LS180_Human1.72160581
37CTBP1_25329375_ChIP-Seq_LNCAP_Human1.70841182
38RAC3_21632823_ChIP-Seq_H3396_Human1.68947978
39EBNA2_21746931_ChIP-Seq_IB4-LCL_Human1.68507226
40ESR1_15608294_ChIP-ChIP_MCF-7_Human1.67212951
41ZFP281_18757296_ChIP-ChIP_E14_Mouse1.67043578
42PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.66074481
43MYC_19829295_ChIP-Seq_ESCs_Human1.65047408
44KDM2B_26808549_Chip-Seq_SUP-B15_Human1.63130025
45ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.62837193
46TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.59583987
47RACK7_27058665_Chip-Seq_MCF-7_Human1.59562745
48OCT4_20526341_ChIP-Seq_ESCs_Human1.58900334
49ATF3_27146783_Chip-Seq_COLON_Human1.58610837
50ESR2_21235772_ChIP-Seq_MCF-7_Human1.58575659
51NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.55881427
52KDM2B_26808549_Chip-Seq_DND41_Human1.55831716
53RBPJ_21746931_ChIP-Seq_IB4-LCL_Human1.55671339
54VDR_21846776_ChIP-Seq_THP-1_Human1.55618574
55CTBP2_25329375_ChIP-Seq_LNCAP_Human1.55008023
56EBNA1_20929547_Chip-Seq_RAJI-cells_Human1.53785957
57EZH2_22144423_ChIP-Seq_EOC_Human1.53618325
58TAF2_19829295_ChIP-Seq_ESCs_Human1.53410337
59EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.53081162
60KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.52777252
61* HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.51835293
62* EGR1_23403033_ChIP-Seq_LIVER_Mouse1.49288088
63POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.49168737
64TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.49168737
65CTCF_20526341_ChIP-Seq_ESCs_Human1.47599560
66REST_21632747_ChIP-Seq_MESCs_Mouse1.46310635
67E2F1_20622854_ChIP-Seq_HELA_Human1.44452457
68YY1_22570637_ChIP-Seq_MALME-3M_Human1.42723567
69KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.42676412
70TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.42108860
71SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.42045881
72TP63_17297297_ChIP-ChIP_HaCaT_Human1.41415478
73EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.41066811
74ETV2_25802403_ChIP-Seq_MESCs_Mouse1.40000946
75REST_18959480_ChIP-ChIP_MESCs_Mouse1.39078023
76ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.39005019
77BCL6_27268052_Chip-Seq_Bcells_Human1.36988986
78P300_27058665_Chip-Seq_ZR-75-30cells_Human1.36587055
79KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.36345759
80* TFEB_21752829_ChIP-Seq_HELA_Human1.33424050
81CTCF_27219007_Chip-Seq_Bcells_Human1.32874384
82NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.32489595
83TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.32342899
84GATA3_21878914_ChIP-Seq_MCF-7_Human1.30602444
85SUZ12_27294783_Chip-Seq_ESCs_Mouse1.30406770
86* JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.30353039
87NANOG_20526341_ChIP-Seq_ESCs_Human1.28572983
88CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.28221470
89SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.28049612
90ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.27662986
91* IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.27480276
92* CBP_20019798_ChIP-Seq_JUKART_Human1.27480276
93* BRD4_27068464_Chip-Seq_AML-cells_Mouse1.26993872
94* RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.25908189
95TCF7L2_21901280_ChIP-Seq_H4IIE_Rat1.24908047
96DROSHA_22980978_ChIP-Seq_HELA_Human1.24470118
97SRY_22984422_ChIP-ChIP_TESTIS_Rat1.23638168
98Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.23511948
99TCF7_22412390_ChIP-Seq_EML_Mouse1.21883427
100SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.21731279
101KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.21483000
102P300_19829295_ChIP-Seq_ESCs_Human1.21218189
103HIF1A_21447827_ChIP-Seq_MCF-7_Human1.20947534
104ESR1_21235772_ChIP-Seq_MCF-7_Human1.20556283
105EZH2_27294783_Chip-Seq_ESCs_Mouse1.20347640
106RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.19152384
107TCF3_18692474_ChIP-Seq_MEFs_Mouse1.19038573
108E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.18990949
109FOXH1_21741376_ChIP-Seq_ESCs_Human1.18831915
110SMAD2/3_21741376_ChIP-Seq_ESCs_Human1.18730305
111EED_16625203_ChIP-ChIP_MESCs_Mouse1.18729689
112AR_25329375_ChIP-Seq_VCAP_Human1.18317907
113LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.18295252
114E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.17428872
115SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.17370318
116KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.17204944
117KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.17204944
118KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.17204944
119TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.17134640
120P53_21459846_ChIP-Seq_SAOS-2_Human1.15265028
121IRF8_27001747_Chip-Seq_BMDM_Mouse1.14427447
122IRF8_22096565_ChIP-ChIP_GC-B_Human1.13842471
123UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.12184884
124UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.11812857
125P63_20808887_ChIP-Seq_KERATINOCYTES_Human1.11061121
126PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.10777034
127SMAD4_21741376_ChIP-Seq_EPCs_Human1.10604594
128NACC1_18358816_ChIP-ChIP_MESCs_Mouse1.10537658
129FOXM1_23109430_ChIP-Seq_U2OS_Human1.10141082
130KDM2B_26808549_Chip-Seq_K562_Human1.09232110
131JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.08531079
132SMAD3_21741376_ChIP-Seq_ESCs_Human1.07812917
133EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.07687083
134PBX1_22567123_ChIP-ChIP_OVCAR3_Human1.07257330
135KLF4_18555785_ChIP-Seq_MESCs_Mouse1.06979396
136* SA1_27219007_Chip-Seq_Bcells_Human1.06637269
137OCT4_18692474_ChIP-Seq_MEFs_Mouse1.06522352
138* RAD21_21589869_ChIP-Seq_MESCs_Mouse1.06437030
139KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.06383294
140CREB1_26743006_Chip-Seq_LNCaP_Human1.04567197
141MYB_21317192_ChIP-Seq_ERMYB_Mouse1.04390856
142ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.03856956
143BCOR_27268052_Chip-Seq_Bcells_Human1.02048767
144SOX2_18358816_ChIP-ChIP_MESCs_Mouse1.01424598
145ZFP57_27257070_Chip-Seq_ESCs_Mouse0.99877624
146NANOG_18555785_ChIP-Seq_MESCs_Mouse0.99837767
147ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.99767426
148WDR5_24793694_ChIP-Seq_LNCAP_Human0.99576941
149PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.99425807
150ERG_21242973_ChIP-ChIP_JURKAT_Human0.99026344
151NANOG_19829295_ChIP-Seq_ESCs_Human0.98593149
152SOX2_19829295_ChIP-Seq_ESCs_Human0.98593149
153ER_23166858_ChIP-Seq_MCF-7_Human0.97954106
154OCT4_19829295_ChIP-Seq_ESCs_Human0.97870594
155ZFP281_27345836_Chip-Seq_ESCs_Mouse0.97480993
156SALL4_18804426_ChIP-ChIP_MESCs_Mouse0.96941314
157CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.96593572
158GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse0.96322432
159CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons0.96259421
160* TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat0.95605598
161P68_20966046_ChIP-Seq_HELA_Human0.95308858
162NEUROD2_26341353_ChIP-Seq_CORTEX_Mouse0.94950334
163TP63_22573176_ChIP-Seq_HFKS_Human0.94934622
164GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.94091517
165SPI1_23127762_ChIP-Seq_K562_Human0.93869143
166RARA_24833708_ChIP-Seq_LIVER_Mouse0.93540716
167SMAD4_21741376_ChIP-Seq_HESCs_Human0.93214634
168DACH1_20351289_ChIP-Seq_MDA-MB-231_Human0.93175062
169SUZ12_20075857_ChIP-Seq_MESCs_Mouse0.92947401
170TFAP2C_20629094_ChIP-Seq_MCF-7_Human0.92751877
171ELF1_20517297_ChIP-Seq_JURKAT_Human0.92248871
172MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human0.91471054
173FOXH1_21741376_ChIP-Seq_EPCs_Human0.91041579
174SOX2_22085726_ChIP-Seq_NPCs_Mouse0.90857176
175SMC4_20622854_ChIP-Seq_HELA_Human0.90460161
176MAF_26560356_Chip-Seq_TH1_Human0.89755675
177FOXA1_27270436_Chip-Seq_PROSTATE_Human0.89728294
178FOXA1_25329375_ChIP-Seq_VCAP_Human0.89728294
179MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.89508334
180TP53_22127205_ChIP-Seq_IMR90_Human0.89426596
181SOX2_21211035_ChIP-Seq_LN229_Human0.89213049
182TP53_22573176_ChIP-Seq_HFKS_Human0.89047438
183FOXP1_21924763_ChIP-Seq_HESCs_Human0.88514919
184PHF8_20622854_ChIP-Seq_HELA_Human0.88472329
185PPARD_21283829_ChIP-Seq_MYOFIBROBLAST_Human0.87916238
186SUZ12_18692474_ChIP-Seq_MESCs_Mouse0.87640818
187RARB_24833708_ChIP-Seq_LIVER_Mouse0.87388828
188CTCF_18555785_ChIP-Seq_MESCs_Mouse0.86755376
189* NCOR_22424771_ChIP-Seq_293T_Human0.86514005
190TET1_21490601_ChIP-Seq_MESCs_Mouse0.86449505
191IKZF1_21737484_ChIP-ChIP_HCT116_Human0.84839067
192GATA3_21867929_ChIP-Seq_CD8_Mouse0.84811486

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005410_abnormal_fertilization5.33864682
2MP0009840_abnormal_foam_cell4.79406985
3MP0002139_abnormal_hepatobiliary_system4.66171982
4MP0005360_urolithiasis3.97960204
5MP0003705_abnormal_hypodermis_morpholog3.85291047
6MP0005058_abnormal_lysosome_morphology3.51832351
7MP0005365_abnormal_bile_salt3.29599455
8MP0005085_abnormal_gallbladder_physiolo3.21404687
9MP0003172_abnormal_lysosome_physiology3.17224030
10MP0003806_abnormal_nucleotide_metabolis2.97354576
11MP0008438_abnormal_cutaneous_collagen2.70693742
12MP0003191_abnormal_cellular_cholesterol2.68631700
13MP0005083_abnormal_biliary_tract2.49664112
14MP0003878_abnormal_ear_physiology2.28465059
15MP0005377_hearing/vestibular/ear_phenot2.28465059
16MP0003646_muscle_fatigue2.27389087
17MP0010329_abnormal_lipoprotein_level2.25898482
18MP0003303_peritoneal_inflammation2.22018601
19MP0003011_delayed_dark_adaptation2.21195788
20MP0005167_abnormal_blood-brain_barrier2.19985263
21MP0008875_abnormal_xenobiotic_pharmacok2.17845998
22MP0000604_amyloidosis2.16956351
23MP0004858_abnormal_nervous_system2.16365402
24MP0004133_heterotaxia2.14473916
25MP0010386_abnormal_urinary_bladder2.09896571
26MP0010352_gastrointestinal_tract_polyps2.02728363
27MP0003252_abnormal_bile_duct2.00885454
28MP0002837_dystrophic_cardiac_calcinosis1.91864874
29MP0005076_abnormal_cell_differentiation1.84201029
30MP0000609_abnormal_liver_physiology1.77350410
31MP0003566_abnormal_cell_adhesion1.75132504
32MP0006082_CNS_inflammation1.71001455
33MP0002102_abnormal_ear_morphology1.63426483
34MP0005332_abnormal_amino_acid1.63170956
35MP0010307_abnormal_tumor_latency1.62622137
36MP0005595_abnormal_vascular_smooth1.61802449
37MP0000569_abnormal_digit_pigmentation1.61607675
38MP0003718_maternal_effect1.60758545
39MP0005670_abnormal_white_adipose1.60673744
40MP0006054_spinal_hemorrhage1.58092547
41MP0003698_abnormal_male_reproductive1.57789950
42MP0003436_decreased_susceptibility_to1.53966805
43MP0005023_abnormal_wound_healing1.52652680
44MP0000538_abnormal_urinary_bladder1.49969679
45MP0005551_abnormal_eye_electrophysiolog1.47052929
46MP0010368_abnormal_lymphatic_system1.46871456
47MP0009046_muscle_twitch1.46618192
48MP0005319_abnormal_enzyme/_coenzyme1.44544847
49MP0002138_abnormal_hepatobiliary_system1.42660015
50MP0003136_yellow_coat_color1.40288582
51MP0001968_abnormal_touch/_nociception1.40226033
52MP0003195_calcinosis1.40030728
53MP0003075_altered_response_to1.38177428
54MP0004510_myositis1.36664495
55MP0002118_abnormal_lipid_homeostasis1.31879452
56MP0002653_abnormal_ependyma_morphology1.27862849
57MP0003329_amyloid_beta_deposits1.27564773
58MP0001542_abnormal_bone_strength1.27444578
59MP0003300_gastrointestinal_ulcer1.26395872
60MP0000598_abnormal_liver_morphology1.26159844
61MP0005084_abnormal_gallbladder_morpholo1.26136835
62MP0005257_abnormal_intraocular_pressure1.25559795
63MP0005464_abnormal_platelet_physiology1.20912610
64MP0000049_abnormal_middle_ear1.20291204
65MP0004019_abnormal_vitamin_homeostasis1.19809447
66MP0004185_abnormal_adipocyte_glucose1.19414580
67MP0002234_abnormal_pharynx_morphology1.19313771
68MP0004233_abnormal_muscle_weight1.15338604
69MP0003186_abnormal_redox_activity1.12910894
70MP0004147_increased_porphyrin_level1.12501538
71MP0009764_decreased_sensitivity_to1.12432152
72MP0002282_abnormal_trachea_morphology1.11796601
73MP0002229_neurodegeneration1.11774053
74MP0000371_diluted_coat_color1.11574184
75MP0001915_intracranial_hemorrhage1.10959339
76MP0001929_abnormal_gametogenesis1.10563899
77MP0009745_abnormal_behavioral_response1.09103838
78MP0002736_abnormal_nociception_after1.08505217
79MP0001849_ear_inflammation1.07874958
80MP0001666_abnormal_nutrient_absorption1.04655559
81MP0003137_abnormal_impulse_conducting1.03908143
82MP0009278_abnormal_bone_marrow1.03882046
83MP0001905_abnormal_dopamine_level1.03597041
84MP0005379_endocrine/exocrine_gland_phen1.03050586
85MP0004130_abnormal_muscle_cell1.02913067
86MP0002269_muscular_atrophy1.02570181
87MP0002557_abnormal_social/conspecific_i1.02519785
88MP0005253_abnormal_eye_physiology1.02027912
89MP0001984_abnormal_olfaction1.01520513
90MP0002938_white_spotting1.01194763
91MP0002064_seizures1.00247827
92MP0006276_abnormal_autonomic_nervous0.99402622
93MP0002572_abnormal_emotion/affect_behav0.95739889
94MP0003279_aneurysm0.95678160
95MP0001324_abnormal_eye_pigmentation0.95584391
96MP0002272_abnormal_nervous_system0.94617238
97MP0003448_altered_tumor_morphology0.94295512
98MP0008961_abnormal_basal_metabolism0.94147030
99MP0009384_cardiac_valve_regurgitation0.92520345
100MP0002733_abnormal_thermal_nociception0.92194463
101MP0002161_abnormal_fertility/fecundity0.91595437
102MP0003122_maternal_imprinting0.90272705
103MP0001970_abnormal_pain_threshold0.90267650
104MP0001529_abnormal_vocalization0.89718785
105MP0000858_altered_metastatic_potential0.89427429
106MP0009643_abnormal_urine_homeostasis0.88574464
107MP0001756_abnormal_urination0.88467631
108MP0003880_abnormal_central_pattern0.87211628
109MP0005666_abnormal_adipose_tissue0.86722395
110MP0000026_abnormal_inner_ear0.86149990
111MP0001533_abnormal_skeleton_physiology0.85748875
112MP0004272_abnormal_basement_membrane0.83968231
113MP0009763_increased_sensitivity_to0.83089254
114MP0005275_abnormal_skin_tensile0.82720620
115MP0001485_abnormal_pinna_reflex0.81720236
116MP0005166_decreased_susceptibility_to0.81681905
117MP0006072_abnormal_retinal_apoptosis0.81505114
118MP0003091_abnormal_cell_migration0.81230215
119MP0001963_abnormal_hearing_physiology0.81196247
120MP0002877_abnormal_melanocyte_morpholog0.80610541
121MP0002419_abnormal_innate_immunity0.80502350
122MP0004947_skin_inflammation0.80151608
123MP0001958_emphysema0.79733101
124MP0005584_abnormal_enzyme/coenzyme_acti0.79483183
125MP0004859_abnormal_synaptic_plasticity0.79422103
126MP0001486_abnormal_startle_reflex0.79420323
127MP0008469_abnormal_protein_level0.79399648
128MP0005195_abnormal_posterior_eye0.79259627
129MP0002089_abnormal_postnatal_growth/wei0.78869939
130MP0003656_abnormal_erythrocyte_physiolo0.78175406
131MP0000733_abnormal_muscle_development0.77473271
132MP0008877_abnormal_DNA_methylation0.76240983
133MP0003690_abnormal_glial_cell0.75738199
134MP0003635_abnormal_synaptic_transmissio0.75210048
135MP0002090_abnormal_vision0.73558111
136MP0004883_abnormal_blood_vessel0.73141006
137MP0002876_abnormal_thyroid_physiology0.72693751
138MP0000343_altered_response_to0.72390591
139MP0003221_abnormal_cardiomyocyte_apopto0.71783163
140MP0000015_abnormal_ear_pigmentation0.70174587
141MP0000230_abnormal_systemic_arterial0.69745134
142MP0000358_abnormal_cell_content/0.69452952
143MP0003633_abnormal_nervous_system0.68721858
144MP0005508_abnormal_skeleton_morphology0.68569200
145MP0002168_other_aberrant_phenotype0.67756367
146MP0002135_abnormal_kidney_morphology0.66725369
147MP0002254_reproductive_system_inflammat0.66709239
148MP0008775_abnormal_heart_ventricle0.66400628
149MP0003283_abnormal_digestive_organ0.65694905
150MP0005197_abnormal_uvea_morphology0.65577148
151MP0005174_abnormal_tail_pigmentation0.65247317
152MP0002067_abnormal_sensory_capabilities0.65235200
153MP0002086_abnormal_extraembryonic_tissu0.65225037
154MP0000955_abnormal_spinal_cord0.65186656
155MP0005375_adipose_tissue_phenotype0.64994244
156MP0003632_abnormal_nervous_system0.63809069
157MP0001730_embryonic_growth_arrest0.62624762
158MP0002136_abnormal_kidney_physiology0.60936739
159MP0000747_muscle_weakness0.60144589
160MP0004197_abnormal_fetal_growth/weight/0.59633319
161MP0005334_abnormal_fat_pad0.58646929
162MP0009642_abnormal_blood_homeostasis0.57674998
163MP0002295_abnormal_pulmonary_circulatio0.57332150
164MP0002088_abnormal_embryonic_growth/wei0.56049549
165MP0009672_abnormal_birth_weight0.55638937
166MP0002078_abnormal_glucose_homeostasis0.55549308
167MP0000249_abnormal_blood_vessel0.55343713
168MP0001672_abnormal_embryogenesis/_devel0.53997133
169MP0005380_embryogenesis_phenotype0.53997133
170MP0002998_abnormal_bone_remodeling0.53725259
171MP0005164_abnormal_response_to0.53588419
172MP0003984_embryonic_growth_retardation0.52281790
173MP0010234_abnormal_vibrissa_follicle0.52278600
174MP0001845_abnormal_inflammatory_respons0.50986465

Predicted human phenotypes

RankGene SetZ-score
1Systemic lupus erythematosus (HP:0002725)4.43805067
2Deep venous thrombosis (HP:0002625)4.29392082
3Xanthomatosis (HP:0000991)4.03586929
4Complement deficiency (HP:0004431)3.90383006
5Increased cerebral lipofuscin (HP:0011813)3.81520442
6Abnormality of monocarboxylic acid metabolism (HP:0010996)3.74140521
7Severe visual impairment (HP:0001141)3.33819235
8Myocardial infarction (HP:0001658)3.26927175
9Abnormality of complement system (HP:0005339)3.20957240
10Hand muscle atrophy (HP:0009130)3.18177959
11Cerebral aneurysm (HP:0004944)3.12723289
12Intrahepatic cholestasis (HP:0001406)3.11303639
13Mucopolysacchariduria (HP:0008155)3.06745919
14Urinary glycosaminoglycan excretion (HP:0003541)3.06745919
15Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)3.06662857
16Congenital stationary night blindness (HP:0007642)3.06595315
17Type II lissencephaly (HP:0007260)3.02758783
18Dysostosis multiplex (HP:0000943)3.02363641
19Abnormality of polysaccharide metabolism (HP:0011012)3.01837729
20Abnormality of glycosaminoglycan metabolism (HP:0004371)3.01837729
21Abnormality of mucopolysaccharide metabolism (HP:0011020)3.01837729
22Glomerulonephritis (HP:0000099)2.99950608
23Hypobetalipoproteinemia (HP:0003563)2.98705762
24Abnormality of aromatic amino acid family metabolism (HP:0004338)2.98364558
25Protrusio acetabuli (HP:0003179)2.98273571
26Abnormality of glycolipid metabolism (HP:0010969)2.97514902
27Abnormality of liposaccharide metabolism (HP:0010968)2.97514902
28Abnormality of glycosphingolipid metabolism (HP:0004343)2.97514902
29Nephronophthisis (HP:0000090)2.97154065
30Distal upper limb amyotrophy (HP:0007149)2.96075037
31Upper limb amyotrophy (HP:0009129)2.96075037
32Chronic hepatic failure (HP:0100626)2.95325610
33Increased neuronal autofluorescent lipopigment (HP:0002074)2.93124225
34Vacuolated lymphocytes (HP:0001922)2.86060432
35Upper motor neuron abnormality (HP:0002127)2.86056896
36Skin nodule (HP:0200036)2.85468316
37Hypoalphalipoproteinemia (HP:0003233)2.80093484
38Attenuation of retinal blood vessels (HP:0007843)2.77496130
39Cervical subluxation (HP:0003308)2.73600479
40Hyperlipoproteinemia (HP:0010980)2.72931102
41Hypolipoproteinemia (HP:0010981)2.70865054
42Abnormality of glutamine family amino acid metabolism (HP:0010902)2.69502259
43Mutism (HP:0002300)2.64343639
44Global brain atrophy (HP:0002283)2.62852522
45Abnormality of the Achilles tendon (HP:0005109)2.60750121
46Abnormality of midbrain morphology (HP:0002418)2.58946564
47Molar tooth sign on MRI (HP:0002419)2.58946564
48Pendular nystagmus (HP:0012043)2.58821941
49Pancreatic cysts (HP:0001737)2.54244000
50Spastic diplegia (HP:0001264)2.53981343
51Abnormality of pyrimidine metabolism (HP:0004353)2.53864245
52Hyperammonemia (HP:0001987)2.52921869
53Abnormality of the lower motor neuron (HP:0002366)2.47521943
54Decreased electroretinogram (ERG) amplitude (HP:0000654)2.45929142
55Axonal loss (HP:0003447)2.45070608
56Polydipsia (HP:0001959)2.42923350
57Abnormal drinking behavior (HP:0030082)2.42923350
58Loss of speech (HP:0002371)2.38117382
59Abnormality of sulfur amino acid metabolism (HP:0004339)2.37504466
60Generalized aminoaciduria (HP:0002909)2.36864607
61Pancreatic fibrosis (HP:0100732)2.36833128
62Abnormality of the common coagulation pathway (HP:0010990)2.35743565
63Mesangial abnormality (HP:0001966)2.35409848
64Achilles tendon contracture (HP:0001771)2.35105758
65Inability to walk (HP:0002540)2.35083490
66Vertebral compression fractures (HP:0002953)2.34599793
67Keratoconus (HP:0000563)2.34329540
68Increased corneal curvature (HP:0100692)2.34329540
69Hypercholesterolemia (HP:0003124)2.34056489
70Abnormal gallbladder physiology (HP:0012438)2.32919892
71Cholecystitis (HP:0001082)2.32919892
72Abnormality of the level of lipoprotein cholesterol (HP:0010979)2.32790941
73Epidermoid cyst (HP:0200040)2.32276914
74Abnormality of dental color (HP:0011073)2.30469533
75Joint hemorrhage (HP:0005261)2.30444358
76Abolished electroretinogram (ERG) (HP:0000550)2.30184186
77Recurrent gram-negative bacterial infections (HP:0005420)2.28764133
78Amelogenesis imperfecta (HP:0000705)2.27033241
79Abnormality of the renal medulla (HP:0100957)2.26654398
80Abnormal biliary tract physiology (HP:0012439)2.24414486
81Bile duct proliferation (HP:0001408)2.24414486
82Opisthotonus (HP:0002179)2.22665069
83Shallow orbits (HP:0000586)2.21555867
84Adactyly (HP:0009776)2.21159177
85Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)2.21120725
86Hyperventilation (HP:0002883)2.20252754
87Nephritis (HP:0000123)2.18078367
88Albinism (HP:0001022)2.17247834
89Polyuria (HP:0000103)2.16862413
90Cerebellar dysplasia (HP:0007033)2.16410132
91Prolonged partial thromboplastin time (HP:0003645)2.14569972
92Decreased central vision (HP:0007663)2.14081772
93Prolonged neonatal jaundice (HP:0006579)2.13995045
94Turricephaly (HP:0000262)2.12057490
95Cortical dysplasia (HP:0002539)2.11087948
96Polyphagia (HP:0002591)2.10757598
97Absent speech (HP:0001344)2.09990681
98Reticulocytosis (HP:0001923)2.07608773
99Esophageal varix (HP:0002040)2.07365869
100Abnormality of proline metabolism (HP:0010907)2.07220026
101Hydroxyprolinuria (HP:0003080)2.07220026
102Abnormal urine output (HP:0012590)2.06891408
103Esotropia (HP:0000565)2.06704546
104Abnormality of macular pigmentation (HP:0008002)2.04457656
105Asymmetric septal hypertrophy (HP:0001670)2.01220438
106Aneurysm (HP:0002617)2.00653328
107Ketosis (HP:0001946)2.00435528
108Abnormality of the motor neurons (HP:0002450)1.99613166
109Abnormal neuron morphology (HP:0012757)1.99613166
110Spastic tetraplegia (HP:0002510)1.95175056
111Abnormal isoelectric focusing of serum transferrin (HP:0003160)1.94893658
112Abnormal protein N-linked glycosylation (HP:0012347)1.94893658
113Abnormal protein glycosylation (HP:0012346)1.94893658
114Abnormal glycosylation (HP:0012345)1.94893658
115Premature rupture of membranes (HP:0001788)1.94670869
116Anterior segment dysgenesis (HP:0007700)1.93875127
117Recurrent corneal erosions (HP:0000495)1.93126532
118Hyperglycinemia (HP:0002154)1.89855012
119Abnormality of the intrinsic pathway (HP:0010989)1.89618825
120Mitral stenosis (HP:0001718)1.88762746
121Progressive inability to walk (HP:0002505)1.87251009
122Bony spicule pigmentary retinopathy (HP:0007737)1.86472470
123Hyperglycinuria (HP:0003108)1.85842786
124Increased CSF protein (HP:0002922)1.85498329
125Hypoglycemic coma (HP:0001325)1.85178159
126Stage 5 chronic kidney disease (HP:0003774)1.84813007
127Disproportionate short-trunk short stature (HP:0003521)1.84438115
128Retinal atrophy (HP:0001105)1.84093352
129Pathologic fracture (HP:0002756)1.83471117
130Progressive cerebellar ataxia (HP:0002073)1.83173153
131True hermaphroditism (HP:0010459)1.82920913
132Amyloidosis (HP:0011034)1.82680874
133Clumsiness (HP:0002312)1.81771212
134Ankle contracture (HP:0006466)1.81517244
135Abnormal rod and cone electroretinograms (HP:0008323)1.81346931
136Abnormality of nucleobase metabolism (HP:0010932)1.80928717
137Retinal dysplasia (HP:0007973)1.80818890
138Bulbous nose (HP:0000414)1.80588235
139Protuberant abdomen (HP:0001538)1.79494968
140Sensorimotor neuropathy (HP:0007141)1.79203951
141Severe muscular hypotonia (HP:0006829)1.79139241
142Abnormality of pyruvate family amino acid metabolism (HP:0010915)1.78837479
143Abnormality of alanine metabolism (HP:0010916)1.78837479
144Hyperalaninemia (HP:0003348)1.78837479
145Occipital encephalocele (HP:0002085)1.78472148
146Congenital sensorineural hearing impairment (HP:0008527)1.77023270
147Personality changes (HP:0000751)1.76788558
148Pseudobulbar signs (HP:0002200)1.76321166
149Congenital hepatic fibrosis (HP:0002612)1.75147680
150Peripheral demyelination (HP:0011096)1.74629227
151Abnormality of the aortic arch (HP:0012303)1.74491514
152Mitral valve prolapse (HP:0001634)1.73321339
153Peritonitis (HP:0002586)1.73017490
154Tetraparesis (HP:0002273)1.72553135
155Disinhibition (HP:0000734)1.71081221
156Tubulointerstitial nephritis (HP:0001970)1.70667310
157Frequent falls (HP:0002359)1.70560253
158Cholelithiasis (HP:0001081)1.70317854
159Neurofibrillary tangles (HP:0002185)1.70316239
160Diminished motivation (HP:0000745)1.69633334
161Neuronal loss in central nervous system (HP:0002529)1.67805379
162Stroke (HP:0001297)1.67630440
163Apathy (HP:0000741)1.67443850
164Atrophic scars (HP:0001075)1.67384388
165Macular degeneration (HP:0000608)1.67148196
166Spastic paraparesis (HP:0002313)1.66862404
167Abnormal cartilage morphology (HP:0002763)1.65600978
168Lissencephaly (HP:0001339)1.65544488
169Cone-rod dystrophy (HP:0000548)1.65048712
170Abnormality of serine family amino acid metabolism (HP:0010894)1.65038859
171Abnormality of glycine metabolism (HP:0010895)1.65038859
172Long toe (HP:0010511)1.64252166
173Hypophosphatemic rickets (HP:0004912)1.64231753
174Abnormality of macrophages (HP:0004311)1.63981127
175Abnormality of the vertebral endplates (HP:0005106)1.63594213
176Agitation (HP:0000713)1.62411219
177Inappropriate behavior (HP:0000719)1.60601217
178Decreased subcutaneous fat (HP:0001002)1.60451649
179Humeroradial synostosis (HP:0003041)1.59932008

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TRIB34.12420651
2ERN14.11927003
3PKN23.95234772
4MAP4K23.71451418
5TESK13.31072332
6ADRBK23.19509903
7INSRR2.63136384
8FRK2.52432956
9RIPK12.45517087
10NEK12.25137743
11MAP3K92.22355095
12WNK32.21792442
13CDK122.20998117
14EPHA22.16474022
15BCKDK2.14723399
16LATS22.08669614
17LIMK12.08349369
18PLK42.07496283
19CAMK1D2.00183009
20SCYL21.95992396
21PLK21.95718618
22FGFR41.91080785
23PTK61.85956969
24WNK41.85000247
25TIE11.84503835
26KSR21.83936504
27GRK11.83821353
28TTN1.77969560
29MAP2K61.77028900
30GRK71.76576595
31PDGFRA1.68323671
32SIK11.64657923
33BMPR1B1.64240857
34EEF2K1.58330647
35MAP3K101.53637450
36BMX1.52151159
37ACVR1B1.51346275
38TLK11.41118448
39DYRK21.39564330
40MAP2K71.35093413
41CSNK1G31.33016409
42MAP3K41.30934362
43CSNK1G21.30544516
44PIM21.29936568
45FLT31.28000388
46PRKCG1.27256432
47MTOR1.26531921
48EPHB21.24570811
49NUAK11.24037237
50DDR21.23543115
51ICK1.22751059
52MAPK131.22031416
53CAMKK11.21522272
54TBK11.21258421
55TRIM281.19633331
56CSNK1G11.19411060
57PAK61.17929421
58ALK1.17044031
59PAK41.15612340
60CAMK1G1.15557466
61PTK21.13817340
62DAPK21.11224561
63TGFBR11.11021773
64STK381.10893783
65TGFBR21.09480404
66DYRK31.09397370
67PNCK1.08611539
68PINK11.08485547
69CSNK1A1L1.07419947
70MUSK1.06445475
71PRKCE0.99126101
72PDK20.98760173
73TYK20.98697685
74TAOK10.97156855
75MAP3K110.94764142
76PRKD20.94289295
77NTRK10.92306349
78CASK0.91851027
79MAPKAPK30.88825032
80TESK20.88610884
81RET0.86542535
82TAOK20.83571852
83MAP3K80.82397653
84CDK60.82130276
85ABL20.81794779
86MAP2K10.80296670
87LRRK20.79666883
88ADRBK10.79235155
89TNIK0.78894870
90MAP3K130.78535649
91BLK0.77297546
92MAP3K30.77259792
93MATK0.76396829
94MAP2K30.74785052
95DAPK30.73815298
96JAK10.73481704
97RIPK40.72953386
98JAK20.70221195
99PTK2B0.69693068
100NEK20.67163551
101PRKCZ0.67007194
102PHKG20.66752309
103PHKG10.66752309
104PAK30.65210461
105CSF1R0.63170283
106STK100.62550654
107FER0.61280801
108PKN10.61082347
109CSK0.59589622
110NTRK30.58937320
111HCK0.57443737
112ERBB40.56731538
113PAK20.56222731
114MAPKAPK50.52051088
115STK38L0.52031418
116MAP3K10.52010630
117ZAP700.51955564
118MAP3K20.51041016
119ARAF0.50936063
120EGFR0.49331592
121CDK40.48925059
122CSNK1A10.48623702
123MAP3K70.48613902
124TYRO30.48540642
125CAMKK20.48474790
126VRK20.48101966
127MAP2K20.48035553
128NEK90.47913735
129MAPK150.47599416
130KIT0.47264580
131PDPK10.47255638
132RPS6KA40.46826478
133MOS0.46731353
134TAOK30.46658384
135EPHA30.46528240
136RPS6KA20.46428187
137CAMK10.46371353
138MAP3K50.46273634
139EPHB10.45716426
140MAPK110.45432247
141IKBKB0.44641913
142MET0.43293738
143PRKD30.42014415
144KDR0.41371728
145PRKAA20.40719791
146DAPK10.40315766
147PRKG20.39868721
148LATS10.39485176
149CAMK2A0.39131654
150CAMK40.39041922
151PRKG10.39041447
152RPS6KA60.39023382
153PIK3CG0.37566537
154IRAK30.37516272
155RPS6KB20.36741358
156MYLK0.35622362
157SIK20.35364420
158DYRK1B0.35265916
159MARK10.34411658
160AKT20.34363958
161ROCK10.34156715
162MST1R0.33702592
163FGFR10.33350778
164LMTK20.33053688
165CHUK0.32880521
166NME10.32685752
167PDK10.32282103
168GRK60.31978918
169PRKACA0.31467115
170PRKCI0.31200152
171MAP2K40.29950958
172PRKCA0.29406854
173STK160.29376335
174CDK30.28766571

Predicted pathways (KEGG)

RankGene SetZ-score
1Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004004.16551731
2Nitrogen metabolism_Homo sapiens_hsa009103.52751820
3Primary bile acid biosynthesis_Homo sapiens_hsa001203.23167888
4Arginine biosynthesis_Homo sapiens_hsa002203.08033470
5Synthesis and degradation of ketone bodies_Homo sapiens_hsa000723.00724873
6Staphylococcus aureus infection_Homo sapiens_hsa051502.69654672
7Collecting duct acid secretion_Homo sapiens_hsa049662.62737596
8Ascorbate and aldarate metabolism_Homo sapiens_hsa000532.58117095
9Complement and coagulation cascades_Homo sapiens_hsa046102.50704541
10Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001302.48933367
11Taurine and hypotaurine metabolism_Homo sapiens_hsa004302.48579520
122-Oxocarboxylic acid metabolism_Homo sapiens_hsa012102.37871967
13Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005632.27721393
14Glycosaminoglycan degradation_Homo sapiens_hsa005312.18229668
15Lysosome_Homo sapiens_hsa041422.00165951
16Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.96016514
17Fatty acid degradation_Homo sapiens_hsa000711.74184254
18Tryptophan metabolism_Homo sapiens_hsa003801.67668182
19Biosynthesis of amino acids_Homo sapiens_hsa012301.67208314
20Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.66309311
21Caffeine metabolism_Homo sapiens_hsa002321.61657584
22Pentose and glucuronate interconversions_Homo sapiens_hsa000401.59605966
23Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.59145523
24Steroid biosynthesis_Homo sapiens_hsa001001.58905800
25Phototransduction_Homo sapiens_hsa047441.54085266
26PPAR signaling pathway_Homo sapiens_hsa033201.52639385
27Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.48883081
28Drug metabolism - other enzymes_Homo sapiens_hsa009831.44665604
29Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.42612688
30Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.40597176
31Rheumatoid arthritis_Homo sapiens_hsa053231.40208273
32Cyanoamino acid metabolism_Homo sapiens_hsa004601.35768038
33Oxidative phosphorylation_Homo sapiens_hsa001901.34482080
34Bile secretion_Homo sapiens_hsa049761.32068798
35One carbon pool by folate_Homo sapiens_hsa006701.31459070
36Carbon metabolism_Homo sapiens_hsa012001.28179406
37Selenocompound metabolism_Homo sapiens_hsa004501.26771152
38Fatty acid elongation_Homo sapiens_hsa000621.26498288
39Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.24370676
40Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.24169132
41Fatty acid metabolism_Homo sapiens_hsa012121.21154777
42Other glycan degradation_Homo sapiens_hsa005111.20807541
43Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.20270074
44Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.19792167
45alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.18076652
46Vitamin B6 metabolism_Homo sapiens_hsa007501.18002740
47Ether lipid metabolism_Homo sapiens_hsa005651.13174964
48Prion diseases_Homo sapiens_hsa050201.11189665
49Starch and sucrose metabolism_Homo sapiens_hsa005001.10677139
50Fat digestion and absorption_Homo sapiens_hsa049751.09619050
51Fatty acid biosynthesis_Homo sapiens_hsa000611.07824888
52Lysine degradation_Homo sapiens_hsa003101.07503437
53Galactose metabolism_Homo sapiens_hsa000521.06369462
54Sulfur metabolism_Homo sapiens_hsa009201.04693318
55Fructose and mannose metabolism_Homo sapiens_hsa000511.04612418
56Vibrio cholerae infection_Homo sapiens_hsa051101.04288180
57mTOR signaling pathway_Homo sapiens_hsa041501.02037400
58Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.01294492
59Nicotine addiction_Homo sapiens_hsa050330.99721740
60Butanoate metabolism_Homo sapiens_hsa006500.99398752
61Central carbon metabolism in cancer_Homo sapiens_hsa052300.99123679
62Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.97521261
63Sphingolipid metabolism_Homo sapiens_hsa006000.96704871
64Basal transcription factors_Homo sapiens_hsa030220.96236354
65RNA polymerase_Homo sapiens_hsa030200.92909595
66Linoleic acid metabolism_Homo sapiens_hsa005910.88314797
67Peroxisome_Homo sapiens_hsa041460.87953106
68Phenylalanine metabolism_Homo sapiens_hsa003600.87904862
69Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.85876402
70Insulin resistance_Homo sapiens_hsa049310.82870237
71beta-Alanine metabolism_Homo sapiens_hsa004100.79231268
72Glutathione metabolism_Homo sapiens_hsa004800.78698543
73Metabolic pathways_Homo sapiens_hsa011000.78410628
74Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.77872709
75Taste transduction_Homo sapiens_hsa047420.76201545
76Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.76101475
77Maturity onset diabetes of the young_Homo sapiens_hsa049500.72264633
78Bladder cancer_Homo sapiens_hsa052190.71827354
79Cysteine and methionine metabolism_Homo sapiens_hsa002700.71537331
80Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.71464374
81Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.70931774
82Pentose phosphate pathway_Homo sapiens_hsa000300.70654316
83Type II diabetes mellitus_Homo sapiens_hsa049300.70504474
84Adipocytokine signaling pathway_Homo sapiens_hsa049200.69554920
85Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.68694971
86Chronic myeloid leukemia_Homo sapiens_hsa052200.68388209
87Tuberculosis_Homo sapiens_hsa051520.68109437
88Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.68078446
89Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.67447728
90Arginine and proline metabolism_Homo sapiens_hsa003300.66773699
91Legionellosis_Homo sapiens_hsa051340.65693850
92Chemical carcinogenesis_Homo sapiens_hsa052040.65445467
93ABC transporters_Homo sapiens_hsa020100.65405743
94Mineral absorption_Homo sapiens_hsa049780.64982371
95Amoebiasis_Homo sapiens_hsa051460.64877917
96Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.64221409
97Olfactory transduction_Homo sapiens_hsa047400.63820205
98Glycerolipid metabolism_Homo sapiens_hsa005610.60410070
99Regulation of autophagy_Homo sapiens_hsa041400.59622695
100Sulfur relay system_Homo sapiens_hsa041220.59349665
101Proteasome_Homo sapiens_hsa030500.58950855
102Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.57120440
103Insulin signaling pathway_Homo sapiens_hsa049100.56528769
104N-Glycan biosynthesis_Homo sapiens_hsa005100.55403802
105Phagosome_Homo sapiens_hsa041450.54939447
106GABAergic synapse_Homo sapiens_hsa047270.54759892
107ECM-receptor interaction_Homo sapiens_hsa045120.54641008
108Morphine addiction_Homo sapiens_hsa050320.54126536
109Folate biosynthesis_Homo sapiens_hsa007900.53988242
110Protein export_Homo sapiens_hsa030600.53578414
111Cardiac muscle contraction_Homo sapiens_hsa042600.53567910
112Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.52764193
113Histidine metabolism_Homo sapiens_hsa003400.52490842
114Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.52159226
115Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.52119948
116Toll-like receptor signaling pathway_Homo sapiens_hsa046200.50464060
117Ovarian steroidogenesis_Homo sapiens_hsa049130.50183309
118Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.49915073
119Osteoclast differentiation_Homo sapiens_hsa043800.49890369
120Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.49597932
121HIF-1 signaling pathway_Homo sapiens_hsa040660.49276926
122Apoptosis_Homo sapiens_hsa042100.49250945
123Carbohydrate digestion and absorption_Homo sapiens_hsa049730.48385150
124Leishmaniasis_Homo sapiens_hsa051400.48233532
125Parkinsons disease_Homo sapiens_hsa050120.47644704
126Proteoglycans in cancer_Homo sapiens_hsa052050.45777155
127Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.45383630
128Huntingtons disease_Homo sapiens_hsa050160.44696395
129Arachidonic acid metabolism_Homo sapiens_hsa005900.44462169
130Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.43795882
131Synaptic vesicle cycle_Homo sapiens_hsa047210.43274648
132Longevity regulating pathway - mammal_Homo sapiens_hsa042110.42718016
133Propanoate metabolism_Homo sapiens_hsa006400.42616606
134Glioma_Homo sapiens_hsa052140.42325939
135Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.41680661
136AMPK signaling pathway_Homo sapiens_hsa041520.40024331
137Tyrosine metabolism_Homo sapiens_hsa003500.39537716
138Neurotrophin signaling pathway_Homo sapiens_hsa047220.39518178
139Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.37184104
140Glutamatergic synapse_Homo sapiens_hsa047240.36869463
141Glycerophospholipid metabolism_Homo sapiens_hsa005640.36303074
142Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.35530498
143Protein digestion and absorption_Homo sapiens_hsa049740.35368891
144Pertussis_Homo sapiens_hsa051330.35323649
145Vitamin digestion and absorption_Homo sapiens_hsa049770.34703086
146Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.34591574
147Pyruvate metabolism_Homo sapiens_hsa006200.32392705
148Notch signaling pathway_Homo sapiens_hsa043300.32052996
149Steroid hormone biosynthesis_Homo sapiens_hsa001400.31634841
150Non-small cell lung cancer_Homo sapiens_hsa052230.31386995
151Retinol metabolism_Homo sapiens_hsa008300.31315470
152Acute myeloid leukemia_Homo sapiens_hsa052210.29945843
153Endocytosis_Homo sapiens_hsa041440.28782027

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