SLC38A8

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a putative sodium-dependent amino-acid/proton antiporter. The protein has eleven transmembrane domains, an extracellular N-terminus and an intracellular C-terminal tail. The protein is a member of the SLC38 sodium-coupled neutral amino acid transporter family of proteins. Mutations in this gene result in foveal hypoplasia with or without optic nerve misrouting and/or anterior segment dysgenesis. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1oocyte development (GO:0048599)9.02409113
2regulation of DNA methylation (GO:0044030)8.78654406
3protein kinase C signaling (GO:0070528)8.68850324
4reproduction (GO:0000003)8.51994084
5positive regulation of calcium ion-dependent exocytosis (GO:0045956)7.88697729
6positive regulation of humoral immune response (GO:0002922)7.76292762
7negative regulation of reproductive process (GO:2000242)7.32576556
8mitotic metaphase plate congression (GO:0007080)6.76232507
9binding of sperm to zona pellucida (GO:0007339)6.58301314
10citrulline biosynthetic process (GO:0019240)6.16511094
11retinal cone cell development (GO:0046549)6.03128828
12piRNA metabolic process (GO:0034587)5.72405356
13regulation of histone H3-K9 methylation (GO:0051570)5.67823996
14metaphase plate congression (GO:0051310)5.44195968
15protein K6-linked ubiquitination (GO:0085020)5.41572768
16regulation of attachment of spindle microtubules to kinetochore (GO:0051988)5.36199579
17positive regulation of histone H3-K4 methylation (GO:0051571)5.29806936
18sperm-egg recognition (GO:0035036)5.29218219
19regulation of steroid hormone secretion (GO:2000831)5.25000784
20regulation of hypersensitivity (GO:0002883)5.23643098
21fertilization (GO:0009566)5.19467819
22single fertilization (GO:0007338)5.18952445
23regulation of phospholipid biosynthetic process (GO:0071071)5.06849233
24female gamete generation (GO:0007292)5.06669919
25regulation of calcium ion-dependent exocytosis (GO:0017158)5.00973982
26regulation of spindle organization (GO:0090224)4.96779801
27meiotic chromosome segregation (GO:0045132)4.92001822
28regulation of exit from mitosis (GO:0007096)4.91994004
29establishment of chromosome localization (GO:0051303)4.90752982
30mitotic chromosome condensation (GO:0007076)4.90035073
31negative regulation of histone methylation (GO:0031061)4.84814931
32positive regulation of reproductive process (GO:2000243)4.76468862
33mitotic sister chromatid segregation (GO:0000070)4.70654631
34oocyte maturation (GO:0001556)4.65443480
35glycine transport (GO:0015816)4.53961551
36DNA replication checkpoint (GO:0000076)4.45280526
37regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway (GO:19022354.42856299
38histone H2A monoubiquitination (GO:0035518)4.42810865
39maturation of 5.8S rRNA (GO:0000460)4.41439717
40regulation of cell maturation (GO:1903429)4.36102888
41histone H2A ubiquitination (GO:0033522)4.34598383
42attachment of spindle microtubules to kinetochore (GO:0008608)4.30116063
43cell-cell recognition (GO:0009988)4.24293179
44regulation of meiosis (GO:0040020)4.20492829
45response to dietary excess (GO:0002021)4.20181850
46snRNA transcription (GO:0009301)4.17934235
47regulation of female gonad development (GO:2000194)4.15537525
48negative regulation of meiosis (GO:0045835)4.14673871
49monoubiquitinated protein deubiquitination (GO:0035520)4.12413595
50negative regulation of DNA-templated transcription, elongation (GO:0032785)4.08814737
51negative regulation of transcription elongation from RNA polymerase II promoter (GO:0034244)4.08814737
52regulation of steroid hormone biosynthetic process (GO:0090030)4.08075965
53positive regulation of chromosome segregation (GO:0051984)4.05079379
54positive regulation of inflammatory response to antigenic stimulus (GO:0002863)4.04957774
55rRNA methylation (GO:0031167)4.04505889
56rRNA modification (GO:0000154)4.04079496
57oogenesis (GO:0048477)4.03261294
58interkinetic nuclear migration (GO:0022027)4.01993419
59regulation of reproductive process (GO:2000241)4.01251331
60regulation of meiosis I (GO:0060631)3.99104986
61negative regulation of retinoic acid receptor signaling pathway (GO:0048387)3.93957473
62protein localization to kinetochore (GO:0034501)3.92294135
63DNA methylation (GO:0006306)3.86907518
64DNA alkylation (GO:0006305)3.86907518
65regulation of double-strand break repair via homologous recombination (GO:0010569)3.86815296
66protein localization to chromosome, centromeric region (GO:0071459)3.85985354
67chromosome segregation (GO:0007059)3.81945431
68positive regulation of gastrulation (GO:2000543)3.78520243
69spindle checkpoint (GO:0031577)3.77646922
70regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)3.76759277
71DNA damage induced protein phosphorylation (GO:0006975)3.76749000
72regulation of chromosome segregation (GO:0051983)3.76389153
73regulation of histone H3-K27 methylation (GO:0061085)3.71820503
74positive regulation of mitotic metaphase/anaphase transition (GO:0045842)3.71245249
75positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)3.71245249
76positive regulation of mitotic sister chromatid separation (GO:1901970)3.71245249
77sister chromatid segregation (GO:0000819)3.69658468
78regulation of mitotic spindle organization (GO:0060236)3.67607755
79DNA methylation involved in gamete generation (GO:0043046)3.67356855
80CENP-A containing nucleosome assembly (GO:0034080)3.67015796
81primitive streak formation (GO:0090009)3.64143157
82protein localization to chromosome (GO:0034502)3.63419588
83sexual reproduction (GO:0019953)3.59109895
84regulation of acute inflammatory response to antigenic stimulus (GO:0002864)3.57102686
85citrulline metabolic process (GO:0000052)3.55236843
86chromatin remodeling at centromere (GO:0031055)3.55179761
87regulation of sister chromatid cohesion (GO:0007063)3.53164072
88DNA damage response, signal transduction resulting in transcription (GO:0042772)3.52769817
89positive regulation of calcium ion import (GO:0090280)3.48573107
90male meiosis (GO:0007140)3.48088864
91purine nucleobase biosynthetic process (GO:0009113)3.45421858
92negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)3.45285539
93regulation of protein polyubiquitination (GO:1902914)3.41415162
94phosphatidylinositol dephosphorylation (GO:0046856)3.41338982
95mitotic nuclear envelope disassembly (GO:0007077)3.40002500
96DNA replication-independent nucleosome organization (GO:0034724)3.38825285
97DNA replication-independent nucleosome assembly (GO:0006336)3.38825285
98negative regulation of chromosome segregation (GO:0051985)3.38560703
99kinetochore assembly (GO:0051382)3.37760333
100regulation of meiotic cell cycle (GO:0051445)3.36927183
101regulation of metaphase/anaphase transition of cell cycle (GO:1902099)3.35365437
102negative regulation of mitotic sister chromatid segregation (GO:0033048)3.35085696
103negative regulation of mitotic metaphase/anaphase transition (GO:0045841)3.35085696
104negative regulation of sister chromatid segregation (GO:0033046)3.35085696
105negative regulation of mitotic sister chromatid separation (GO:2000816)3.35085696
106centriole replication (GO:0007099)3.34480207
107DNA replication-dependent nucleosome assembly (GO:0006335)3.30082138
108DNA replication-dependent nucleosome organization (GO:0034723)3.30082138
109positive regulation of histone methylation (GO:0031062)3.29620127
110meiosis I (GO:0007127)3.29278989
111mitotic spindle checkpoint (GO:0071174)3.28785058
112histone exchange (GO:0043486)3.27743339
113regulation of mitotic metaphase/anaphase transition (GO:0030071)3.27306950
114notochord development (GO:0030903)3.26452319
115stress granule assembly (GO:0034063)3.26337324
116DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 cla3.25717256
117positive regulation of hormone biosynthetic process (GO:0046886)3.23995273
118synaptonemal complex assembly (GO:0007130)3.23107073
119kinetochore organization (GO:0051383)3.22303421
120regulation of transcription from RNA polymerase II promoter in response to oxidative stress (GO:00433.22214550
121protein K11-linked ubiquitination (GO:0070979)3.22191957
122phosphorelay signal transduction system (GO:0000160)3.22034037
123inner cell mass cell proliferation (GO:0001833)3.21923787
124sphingosine metabolic process (GO:0006670)3.21507089
125male meiosis I (GO:0007141)3.21191764
126phospholipid dephosphorylation (GO:0046839)3.20263872
127regulation of chromatin silencing (GO:0031935)3.20254227
128ribosome assembly (GO:0042255)3.19281040
129negative regulation of hormone biosynthetic process (GO:0032353)3.19090180
130pyrimidine deoxyribonucleotide catabolic process (GO:0009223)3.19041296
131regulation of histone H3-K4 methylation (GO:0051569)3.18969212
132reciprocal meiotic recombination (GO:0007131)3.18820991
133reciprocal DNA recombination (GO:0035825)3.18820991
134nuclear envelope disassembly (GO:0051081)3.18815083
135membrane disassembly (GO:0030397)3.18815083
136mitotic spindle assembly checkpoint (GO:0007094)3.18246868
137meiotic cell cycle process (GO:1903046)3.14717495
138intestinal epithelial cell development (GO:0060576)3.14432937
1397-methylguanosine mRNA capping (GO:0006370)3.14420230
140meiotic cell cycle (GO:0051321)3.13960682
141phospholipase C-activating dopamine receptor signaling pathway (GO:0060158)3.12947795
142spindle assembly checkpoint (GO:0071173)3.11393577
143positive regulation of mitochondrial membrane permeability involved in apoptotic process (GO:19021103.10815672
144mitochondrial outer membrane permeabilization involved in programmed cell death (GO:1902686)3.10815672
145regulation of mitotic sister chromatid separation (GO:0010965)3.10815285
146regulation of mitotic sister chromatid segregation (GO:0033047)3.10815285
147regulation of sister chromatid segregation (GO:0033045)3.10815285
148mismatch repair (GO:0006298)3.09589153
149regulation of transforming growth factor beta2 production (GO:0032909)3.09246731
150microtubule nucleation (GO:0007020)3.08962640
151gene silencing (GO:0016458)3.08022654
152negative regulation of smooth muscle cell differentiation (GO:0051151)3.06978766
153vitamin transmembrane transport (GO:0035461)3.06574011
154RNA capping (GO:0036260)3.06166709
1557-methylguanosine RNA capping (GO:0009452)3.06166709
156transcription elongation from RNA polymerase II promoter (GO:0006368)3.05504530
157protein complex localization (GO:0031503)3.02562049
158positive regulation of DNA-dependent DNA replication (GO:2000105)3.01618866
159gene silencing by RNA (GO:0031047)3.00072990
160regulation of retinoic acid receptor signaling pathway (GO:0048385)2.98436161
161synapsis (GO:0007129)2.97541960
162negative regulation of hormone metabolic process (GO:0032351)2.92322682
163synaptonemal complex organization (GO:0070193)2.90512114
164positive regulation of uterine smooth muscle contraction (GO:0070474)2.90455437
165regulation of histone methylation (GO:0031060)2.89999309
166startle response (GO:0001964)2.87156964
167peptidyl-arginine modification (GO:0018195)2.85764086
168dopamine biosynthetic process (GO:0042416)2.85305923
169regulation of corticosteroid hormone secretion (GO:2000846)2.84948045
170negative regulation of histone modification (GO:0031057)2.83399951
171N-terminal protein amino acid acetylation (GO:0006474)2.77947456
172germ cell development (GO:0007281)2.77298647
173chromosome organization involved in meiosis (GO:0070192)2.76631933
174L-amino acid import (GO:0043092)2.76621315
175DNA methylation or demethylation (GO:0044728)2.75845006
176regulation of hormone biosynthetic process (GO:0046885)2.75785890
177cellular response to pH (GO:0071467)2.72848617
178positive regulation of endothelial cell differentiation (GO:0045603)2.70997506
179regulation of acrosome reaction (GO:0060046)13.4576774
180multicellular organism reproduction (GO:0032504)10.8173146

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human6.83054217
2FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse6.39551323
3FOXM1_23109430_ChIP-Seq_U2OS_Human5.49791013
4E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse4.42468809
5MYCN_21190229_ChIP-Seq_SHEP-21N_Human3.98370696
6FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human3.87667869
7KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.44786701
8SALL1_21062744_ChIP-ChIP_HESCs_Human3.24260900
9PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse2.88520730
10E2F4_17652178_ChIP-ChIP_JURKAT_Human2.87160428
11KAP1_22055183_ChIP-Seq_ESCs_Mouse2.86192164
12AR_21909140_ChIP-Seq_LNCAP_Human2.80437937
13RBPJ_22232070_ChIP-Seq_NCS_Mouse2.57591778
14KLF5_18264089_ChIP-ChIP_MESCs_Mouse2.52997454
15KLF4_18264089_ChIP-ChIP_MESCs_Mouse2.52997454
16KLF2_18264089_ChIP-ChIP_MESCs_Mouse2.52997454
17JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.44627005
18SMAD_19615063_ChIP-ChIP_OVARY_Human2.39940176
19MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.35758916
20TP63_19390658_ChIP-ChIP_HaCaT_Human2.27496741
21CREB1_15753290_ChIP-ChIP_HEK293T_Human2.24721237
22GABP_17652178_ChIP-ChIP_JURKAT_Human2.22841396
23FLI1_27457419_Chip-Seq_LIVER_Mouse2.16587162
24KDM5B_21448134_ChIP-Seq_MESCs_Mouse2.09871107
25CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.02357948
26EZH2_22144423_ChIP-Seq_EOC_Human16.9313298
27NANOG_18555785_ChIP-Seq_MESCs_Mouse1.94317003
28MYC_18555785_ChIP-Seq_MESCs_Mouse1.93011185
29MYCN_18555785_ChIP-Seq_MESCs_Mouse1.86931317
30ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.84725468
31ETS1_20019798_ChIP-Seq_JURKAT_Human1.82241916
32GATA1_26923725_Chip-Seq_HPCs_Mouse1.79457076
33E2F1_21310950_ChIP-Seq_MCF-7_Human1.69621338
34EST1_17652178_ChIP-ChIP_JURKAT_Human1.69505555
35NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.68455838
36PCGF2_27294783_Chip-Seq_ESCs_Mouse1.65670057
37PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.60927649
38MYC_19030024_ChIP-ChIP_MESCs_Mouse1.57388970
39HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.55544877
40VDR_23849224_ChIP-Seq_CD4+_Human1.54546910
41GABP_19822575_ChIP-Seq_HepG2_Human1.53984312
42BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.49997074
43MYC_18358816_ChIP-ChIP_MESCs_Mouse1.49397580
44NELFA_20434984_ChIP-Seq_ESCs_Mouse1.48023369
45CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.47999840
46TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.44173131
47CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.41900470
48GBX2_23144817_ChIP-Seq_PC3_Human1.40622028
49MYC_18940864_ChIP-ChIP_HL60_Human1.40167484
50KDM5A_27292631_Chip-Seq_BREAST_Human1.39650070
51DCP1A_22483619_ChIP-Seq_HELA_Human1.37391121
52HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.35761436
53* SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.33751813
54KLF4_18555785_ChIP-Seq_MESCs_Mouse1.32482204
55MYC_19079543_ChIP-ChIP_MESCs_Mouse1.31332789
56NFE2_27457419_Chip-Seq_LIVER_Mouse1.29631846
57LMO2_26923725_Chip-Seq_MACROPHAGESS_Mouse1.28378166
58SUZ12_27294783_Chip-Seq_NPCs_Mouse1.25170093
59FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.23473800
60NANOG_21062744_ChIP-ChIP_HESCs_Human1.18589223
61E2F1_18555785_ChIP-Seq_MESCs_Mouse1.17584630
62PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.16940084
63E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.16634300
64POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.15524525
65TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.15524525
66GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.14897506
67HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.14108579
68YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.11119966
69SMAD4_21741376_ChIP-Seq_EPCs_Human1.09790526
70TCF4_23295773_ChIP-Seq_U87_Human1.08615025
71MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.06922741
72RUNX1_26923725_Chip-Seq_HPCs_Mouse1.06396107
73NOTCH1_21737748_ChIP-Seq_TLL_Human1.05746379
74EP300_21415370_ChIP-Seq_HL-1_Mouse1.05315677
75KAP1_27257070_Chip-Seq_ESCs_Mouse1.04889986
76POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.04261642
77TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.03415331
78DROSHA_22980978_ChIP-Seq_HELA_Human1.03347695
79AR_25329375_ChIP-Seq_VCAP_Human1.03308799
80CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.02103178
81CBP_20019798_ChIP-Seq_JUKART_Human1.01518418
82IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.01518418
83GATA1_19941827_ChIP-Seq_MEL86_Mouse1.01359827
84SOX2_19030024_ChIP-ChIP_MESCs_Mouse1.00224893
85SMAD4_21799915_ChIP-Seq_A2780_Human1.00022807
86REST_21632747_ChIP-Seq_MESCs_Mouse0.99029014
87CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat0.98347776
88CIITA_25753668_ChIP-Seq_RAJI_Human0.97541228
89ESR1_20079471_ChIP-ChIP_T-47D_Human0.97467208
90UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human0.97128922
91XRN2_22483619_ChIP-Seq_HELA_Human0.96861855
92NANOG_20526341_ChIP-Seq_ESCs_Human0.96588874
93SALL4_18804426_ChIP-ChIP_MESCs_Mouse0.96243118
94CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse0.95941309
95HOXB4_20404135_ChIP-ChIP_EML_Mouse0.95736697
96EZH2_27294783_Chip-Seq_NPCs_Mouse0.94500041
97RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.94489448
98TOP2B_26459242_ChIP-Seq_MCF-7_Human0.94052087
99STAT3_23295773_ChIP-Seq_U87_Human0.93088699
100CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.92098844
101SRF_21415370_ChIP-Seq_HL-1_Mouse0.92060315
102TRIM28_17542650_ChIP-ChIP_NTERA2_Human0.90887945
103NANOG_18555785_Chip-Seq_ESCs_Mouse0.89840230
104* PRDM14_20953172_ChIP-Seq_ESCs_Human0.89420360
105NMYC_18555785_Chip-Seq_ESCs_Mouse0.89150113
106DACH1_20351289_ChIP-Seq_MDA-MB-231_Human0.88851333
107PADI4_21655091_ChIP-ChIP_MCF-7_Human0.88664482
108YY1_21170310_ChIP-Seq_MESCs_Mouse0.86755369
109STAT3_18555785_Chip-Seq_ESCs_Mouse0.85596171
110SPI1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.85374700
111GF1_26923725_Chip-Seq_HPCs_Mouse0.85239885
112SMAD3_21741376_ChIP-Seq_EPCs_Human0.84926669
113NOTCH1_17114293_ChIP-ChIP_T-ALL_Human0.84623322
114GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse0.84249074
115NANOG_18358816_ChIP-ChIP_MESCs_Mouse0.84052228
116FOXH1_21741376_ChIP-Seq_EPCs_Human0.83767578
117ZNF274_21170338_ChIP-Seq_K562_Hela0.83408288
118SMAD2/3_21741376_ChIP-Seq_EPCs_Human0.83139763
119DMRT1_21621532_ChIP-ChIP_FETAL_Ovary0.82171195
120* RUNX2_22187159_ChIP-Seq_PCA_Human0.82104289
121FOXP3_21729870_ChIP-Seq_TREG_Human0.81979196
122* STAT1_17558387_ChIP-Seq_HELA_Human0.79344539
123NFYA_21822215_ChIP-Seq_K562_Human0.79001401
124ASH2L_23239880_ChIP-Seq_MESCs_Mouse0.78987864
125TBX5_21415370_ChIP-Seq_HL-1_Mouse0.78586043
126KLF4_18555785_Chip-Seq_ESCs_Mouse0.78561614
127CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse0.78483970
128TTF2_22483619_ChIP-Seq_HELA_Human0.78316880
129HCFC1_20581084_ChIP-Seq_MESCs_Mouse0.78131216
130OCT4_21477851_ChIP-Seq_ESCs_Mouse0.77553864
131* KLF4_19829295_ChIP-Seq_ESCs_Human0.77414799
132SMRT_27268052_Chip-Seq_Bcells_Human0.77187467
133NANOG_18347094_ChIP-ChIP_MESCs_Mouse0.77114930
134CRX_20693478_ChIP-Seq_RETINA_Mouse0.76914654
135ZFX_18555785_Chip-Seq_ESCs_Mouse0.76804699
136* OCT4_19829295_ChIP-Seq_ESCs_Human0.76291456
137TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse0.75671410
138SMAD3_21741376_ChIP-Seq_ESCs_Human0.75479054
139AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.75341028
140AHR_22903824_ChIP-Seq_MCF-7_Human0.74589061
141NCOR_22424771_ChIP-Seq_293T_Human0.74554539
142ETV1_20927104_ChIP-Seq_GIST48_Human0.74496790
143NR4A2_19515692_ChIP-ChIP_MN9D_Mouse0.74472763
144ZFX_18555785_ChIP-Seq_MESCs_Mouse0.74444910
145TCFCP2L1_18555785_ChIP-Seq_MESCs_Mouse0.74133492
146THAP11_20581084_ChIP-Seq_MESCs_Mouse0.73748515
147SMAD2/3_21741376_ChIP-Seq_ESCs_Human0.73560554
148LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.72869184
149AUTS2_25519132_ChIP-Seq_293T-REX_Human0.72853544
150TBL1_22424771_ChIP-Seq_293T_Human0.72578570
151EZH2_27304074_Chip-Seq_ESCs_Mouse0.72578342
152SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.72418944
153SOX2_21211035_ChIP-Seq_LN229_Gbm0.71549651
154FOXO1_23066095_ChIP-Seq_LIVER_Mouse0.70999242
155SOX2_18555785_Chip-Seq_ESCs_Mouse0.70546101
156CDX2_22108803_ChIP-Seq_LS180_Human0.70471975
157ZNF217_24962896_ChIP-Seq_MCF-7_Human0.70224958
158TFAP2C_20629094_ChIP-Seq_MCF-7_Human0.70206250
159ELK4_26923725_Chip-Seq_MESODERM_Mouse0.68983489
160* P63_20808887_ChIP-Seq_KERATINOCYTES_Human0.68796650
161BMI1_23680149_ChIP-Seq_NPCS_Mouse0.68233789
162CTBP1_25329375_ChIP-Seq_LNCAP_Human0.68160249
163AR_19668381_ChIP-Seq_PC3_Human0.67746386
164BCL6_25482012_ChIP-Seq_CML-JURL-MK1_Human0.67572186
165PKCTHETA_26484144_Chip-Seq_BREAST_Human0.67086835
166P300_19829295_ChIP-Seq_ESCs_Human0.66720509
167FOXM1_26456572_ChIP-Seq_MCF-7_Human0.66553597
168NR3C1_21868756_ChIP-Seq_MCF10A_Human0.64741120
169SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.63871243
170EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human0.63483642
171GATA3_21878914_ChIP-Seq_MCF-7_Human0.63110374
172BCAT_22108803_ChIP-Seq_LS180_Human0.62882219
173ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.62510229
174CTNNB1_20460455_ChIP-Seq_HCT116_Human0.62213285
175* NR3C1_23031785_ChIP-Seq_PC12_Mouse0.61453461
176* MITF_21258399_ChIP-Seq_MELANOMA_Human0.60873419
177TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.60777132
178JUN_21703547_ChIP-Seq_K562_Human0.60472099
179KLF1_20508144_ChIP-Seq_FETAL-LIVER-ERYTHROID_Mouse0.59939840
180TP53_22573176_ChIP-Seq_HFKS_Human0.58179458
181CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse0.57894428

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003693_abnormal_embryo_hatching6.17898311
2MP0003718_maternal_effect5.45918395
3MP0002653_abnormal_ependyma_morphology4.66660181
4MP0003646_muscle_fatigue4.07496206
5MP0003111_abnormal_nucleus_morphology3.91043323
6MP0010094_abnormal_chromosome_stability3.62707248
7MP0005451_abnormal_body_composition3.54460785
8MP0003077_abnormal_cell_cycle3.44411442
9MP0004957_abnormal_blastocyst_morpholog3.40448010
10MP0008877_abnormal_DNA_methylation3.16017431
11MP0008057_abnormal_DNA_replication3.01829263
12MP0002102_abnormal_ear_morphology2.91082058
13MP0008789_abnormal_olfactory_epithelium2.86733743
14MP0008058_abnormal_DNA_repair2.54062126
15MP0005394_taste/olfaction_phenotype2.51104303
16MP0005499_abnormal_olfactory_system2.51104303
17MP0002139_abnormal_hepatobiliary_system2.50044325
18MP0008260_abnormal_autophagy2.47172551
19MP0002163_abnormal_gland_morphology2.38587328
20MP0005410_abnormal_fertilization2.38241074
21MP0001119_abnormal_female_reproductive2.30716608
22MP0005395_other_phenotype2.30667409
23MP0003123_paternal_imprinting2.22905395
24MP0008961_abnormal_basal_metabolism2.17420413
25MP0002138_abnormal_hepatobiliary_system2.08857514
26MP0001502_abnormal_circadian_rhythm2.08608133
27MP0001929_abnormal_gametogenesis2.06400576
28MP0002210_abnormal_sex_determination2.02635403
29MP0003699_abnormal_female_reproductive2.00717391
30MP0006292_abnormal_olfactory_placode1.95351925
31MP0008007_abnormal_cellular_replicative1.87120992
32MP0008932_abnormal_embryonic_tissue1.85099529
33MP0001346_abnormal_lacrimal_gland1.84519075
34MP0005075_abnormal_melanosome_morpholog1.83961463
35MP0000653_abnormal_sex_gland1.83213399
36MP0001730_embryonic_growth_arrest1.82776718
37MP0003959_abnormal_lean_body1.72325056
38MP0000350_abnormal_cell_proliferation1.66821427
39MP0000566_synostosis1.64947308
40MP0005360_urolithiasis1.61721513
41MP0003195_calcinosis1.60643965
42MP0005310_abnormal_salivary_gland1.54841540
43MP0002272_abnormal_nervous_system1.52827244
44MP0001145_abnormal_male_reproductive1.51493154
45MP0005379_endocrine/exocrine_gland_phen1.49042252
46MP0010368_abnormal_lymphatic_system1.46067296
47MP0003890_abnormal_embryonic-extraembry1.44881771
48MP0001529_abnormal_vocalization1.37040186
49MP0005171_absent_coat_pigmentation1.36294104
50MP0003950_abnormal_plasma_membrane1.32924095
51MP0003937_abnormal_limbs/digits/tail_de1.31564331
52MP0004381_abnormal_hair_follicle1.30210651
53MP0002085_abnormal_embryonic_tissue1.29805160
54MP0009333_abnormal_splenocyte_physiolog1.29481350
55MP0005389_reproductive_system_phenotype1.28417889
56MP0005380_embryogenesis_phenotype1.27344214
57MP0001672_abnormal_embryogenesis/_devel1.27344214
58MP0001984_abnormal_olfaction1.25540875
59MP0001697_abnormal_embryo_size1.25405032
60MP0001664_abnormal_digestion1.25101690
61MP0005646_abnormal_pituitary_gland1.24514128
62MP0001324_abnormal_eye_pigmentation1.24410151
63MP0002234_abnormal_pharynx_morphology1.22376758
64MP0002160_abnormal_reproductive_system1.21942925
65MP0005551_abnormal_eye_electrophysiolog1.20512073
66MP0005409_darkened_coat_color1.20109961
67MP0003121_genomic_imprinting1.19385463
68MP0005408_hypopigmentation1.18692847
69MP0000003_abnormal_adipose_tissue1.17947204
70MP0002161_abnormal_fertility/fecundity1.15598354
71MP0009697_abnormal_copulation1.15586503
72MP0003136_yellow_coat_color1.14151080
73MP0003315_abnormal_perineum_morphology1.11826919
74MP0010234_abnormal_vibrissa_follicle1.09714459
75MP0002019_abnormal_tumor_incidence1.06276216
76MP0000631_abnormal_neuroendocrine_gland1.04583947
77MP0002089_abnormal_postnatal_growth/wei1.02971998
78MP0003786_premature_aging1.02664556
79MP0005423_abnormal_somatic_nervous1.01303360
80MP0000490_abnormal_crypts_of1.01277533
81MP0010307_abnormal_tumor_latency1.00826953
82MP0003938_abnormal_ear_development0.99868951
83MP0003183_abnormal_peptide_metabolism0.98084761
84MP0000579_abnormal_nail_morphology0.97348457
85MP0003984_embryonic_growth_retardation0.97103249
86MP0000462_abnormal_digestive_system0.96443549
87MP0002095_abnormal_skin_pigmentation0.96439756
88MP0005174_abnormal_tail_pigmentation0.93586053
89MP0004264_abnormal_extraembryonic_tissu0.93404724
90MP0002084_abnormal_developmental_patter0.92273349
91MP0002088_abnormal_embryonic_growth/wei0.92236816
92MP0005621_abnormal_cell_physiology0.89931540
93MP0001919_abnormal_reproductive_system0.89470237
94MP0005257_abnormal_intraocular_pressure0.89177940
95MP0002080_prenatal_lethality0.87401002
96MP0005085_abnormal_gallbladder_physiolo0.86536810
97MP0008004_abnormal_stomach_pH0.85781793
98MP0001666_abnormal_nutrient_absorption0.85489384
99MP0004885_abnormal_endolymph0.85135884
100MP0001963_abnormal_hearing_physiology0.83064113
101MP0008995_early_reproductive_senescence0.82788036
102MP0001661_extended_life_span0.81701252
103MP0000013_abnormal_adipose_tissue0.80550551
104MP0000678_abnormal_parathyroid_gland0.79804477
105MP0000015_abnormal_ear_pigmentation0.79215222
106MP0002229_neurodegeneration0.78934096
107MP0001944_abnormal_pancreas_morphology0.78589833
108MP0000313_abnormal_cell_death0.78231831
109MP0003698_abnormal_male_reproductive0.77382564
110MP0010030_abnormal_orbit_morphology0.76257670
111MP0001881_abnormal_mammary_gland0.76126203
112MP0000372_irregular_coat_pigmentation0.75785854
113MP0003252_abnormal_bile_duct0.74324494
114MP0002249_abnormal_larynx_morphology0.73818104
115MP0002638_abnormal_pupillary_reflex0.73749927
116MP0000427_abnormal_hair_cycle0.73670493
117MP0000470_abnormal_stomach_morphology0.73140975
118MP0004185_abnormal_adipocyte_glucose0.72290641
119MP0001293_anophthalmia0.71729343
120MP0001486_abnormal_startle_reflex0.70872466
121MP0003879_abnormal_hair_cell0.69769159
122MP0002086_abnormal_extraembryonic_tissu0.69502749
123MP0003221_abnormal_cardiomyocyte_apopto0.69000163
124MP0004233_abnormal_muscle_weight0.68532345
125MP0005384_cellular_phenotype0.68271369
126MP0003763_abnormal_thymus_physiology0.66462285
127MP0002177_abnormal_outer_ear0.64829916
128MP0002876_abnormal_thyroid_physiology0.63130946
129MP0009840_abnormal_foam_cell0.62319116
130MP0006072_abnormal_retinal_apoptosis0.62092204
131MP0003635_abnormal_synaptic_transmissio0.61524067
132MP0002127_abnormal_cardiovascular_syste0.61495635
133MP0003567_abnormal_fetal_cardiomyocyte0.60052090
134MP0000613_abnormal_salivary_gland0.59438468
135MP0003119_abnormal_digestive_system0.59406235
136MP0005647_abnormal_sex_gland0.59358743
137MP0002734_abnormal_mechanical_nocicepti0.58441602
138MP0004270_analgesia0.58215776
139MP0009745_abnormal_behavioral_response0.58195233
140MP0000627_abnormal_mammary_gland0.57634914
141MP0002090_abnormal_vision0.57591165
142MP0003953_abnormal_hormone_level0.57332206
143MP0005248_abnormal_Harderian_gland0.55644903
144MP0004142_abnormal_muscle_tone0.55519028
145MP0002233_abnormal_nose_morphology0.52356175
146MP0003787_abnormal_imprinting0.51882426
147MP0001986_abnormal_taste_sensitivity0.51839926
148MP0002396_abnormal_hematopoietic_system0.51546298
149MP0001905_abnormal_dopamine_level0.51207135
150MP0005187_abnormal_penis_morphology0.50901066
151MP0003755_abnormal_palate_morphology0.48425140
152MP0003936_abnormal_reproductive_system0.48127513
153MP0005076_abnormal_cell_differentiation0.46882243
154MP0001915_intracranial_hemorrhage0.45606159
155MP0001545_abnormal_hematopoietic_system0.45597492
156MP0005397_hematopoietic_system_phenotyp0.45597492

Predicted human phenotypes

RankGene SetZ-score
1Birth length less than 3rd percentile (HP:0003561)6.87088880
2Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)5.30579166
3Breast hypoplasia (HP:0003187)5.23196644
4Abnormal gallbladder physiology (HP:0012438)5.15605233
5Cholecystitis (HP:0001082)5.15605233
6Hypophosphatemic rickets (HP:0004912)4.47272008
7Male infertility (HP:0003251)4.44927299
8Patellar aplasia (HP:0006443)4.39739099
9Osteomalacia (HP:0002749)4.37832092
10Abnormality of the labia minora (HP:0012880)4.30358787
11Abnormality of abdominal situs (HP:0011620)4.27307398
12Abdominal situs inversus (HP:0003363)4.27307398
13Hypokinesia (HP:0002375)4.23793603
14Wrist flexion contracture (HP:0001239)4.19892082
15Chromsome breakage (HP:0040012)4.17160670
16Hypoplasia of the capital femoral epiphysis (HP:0003090)4.16157298
17Elevated circulating parathyroid hormone (PTH) level (HP:0003165)4.15168156
18Adrenal hypoplasia (HP:0000835)4.14314166
19Aplasia/Hypoplasia of the patella (HP:0006498)4.04571877
20Abnormality of aromatic amino acid family metabolism (HP:0004338)3.77656604
21Chromosomal breakage induced by crosslinking agents (HP:0003221)3.74579072
22Apathy (HP:0000741)3.62097886
23Premature ovarian failure (HP:0008209)3.57020603
24Carpal bone hypoplasia (HP:0001498)3.56179053
25Ocular albinism (HP:0001107)3.50424157
26Oligodactyly (hands) (HP:0001180)3.47976183
27Flat capital femoral epiphysis (HP:0003370)3.43323293
28Azoospermia (HP:0000027)3.42172893
29Diminished motivation (HP:0000745)3.35744197
30Aplasia/Hypoplasia involving the carpal bones (HP:0006502)3.33058516
31Congenital sensorineural hearing impairment (HP:0008527)3.30013557
32Breast aplasia (HP:0100783)3.27344396
33Capillary hemangiomas (HP:0005306)3.25450884
34Impulsivity (HP:0100710)3.24829196
35Absent epiphyses (HP:0010577)3.22600718
36Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)3.22600718
37Gonadotropin excess (HP:0000837)3.19286401
38Oligodactyly (HP:0012165)3.13365601
39Papillary thyroid carcinoma (HP:0002895)3.12947349
40Aplasia/Hypoplasia of the breasts (HP:0010311)3.10809690
41Cortical dysplasia (HP:0002539)3.10037827
42Enlarged penis (HP:0000040)3.08054494
43Secondary amenorrhea (HP:0000869)3.07795117
44Facial hemangioma (HP:0000329)3.06146806
45Shawl scrotum (HP:0000049)3.05659653
46Increased circulating renin level (HP:0000848)3.05293067
47Metaphyseal irregularity (HP:0003025)3.03528413
48Dysmetric saccades (HP:0000641)3.03270911
49Septo-optic dysplasia (HP:0100842)2.97516664
50Iris hypopigmentation (HP:0007730)2.94363513
51Abnormality of calcium-phosphate metabolism (HP:0100530)2.92109669
52Pancreatic fibrosis (HP:0100732)2.89103979
53Malnutrition (HP:0004395)2.79318997
54Abnormality of the femoral head (HP:0003368)2.75756854
55Generalized hypopigmentation of hair (HP:0011358)2.75675377
56Loss of speech (HP:0002371)2.72993086
57Aplasia/Hypoplasia of the uvula (HP:0010293)2.72215530
58Dysdiadochokinesis (HP:0002075)2.68645821
59Truncal obesity (HP:0001956)2.65340491
60Abnormality of alanine metabolism (HP:0010916)2.62923188
61Hyperalaninemia (HP:0003348)2.62923188
62Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.62923188
63Irregular epiphyses (HP:0010582)2.58574737
64Abnormality of the epiphysis of the femoral head (HP:0010574)2.56054844
65Abnormality of chromosome stability (HP:0003220)2.52917803
66Type 2 muscle fiber atrophy (HP:0003554)2.50962540
67Absent radius (HP:0003974)2.48327729
68Insulin-resistant diabetes mellitus (HP:0000831)2.47912012
69Postural instability (HP:0002172)2.47414357
70Abnormality of the preputium (HP:0100587)2.46797483
71Absent septum pellucidum (HP:0001331)2.46172445
72Rhabdomyosarcoma (HP:0002859)2.45447755
73Median cleft lip (HP:0000161)2.44483967
74Conjunctival telangiectasia (HP:0000524)2.43297459
75* Hypoplasia of the fovea (HP:0007750)2.42653752
76* Aplasia/Hypoplasia of the fovea (HP:0008060)2.42653752
77Pancreatic cysts (HP:0001737)2.42067448
78Meckel diverticulum (HP:0002245)2.40930538
79Aplasia involving forearm bones (HP:0009822)2.39925582
80Absent forearm bone (HP:0003953)2.39925582
81Myokymia (HP:0002411)2.38437962
82Hyperglycemia (HP:0003074)2.38130872
83White forelock (HP:0002211)2.36607120
84Postural tremor (HP:0002174)2.32308511
85Hypoplastic iliac wings (HP:0002866)2.31126943
86Spinal cord compression (HP:0002176)2.27956949
87Parkinsonism with favorable response to dopaminergic medication (HP:0002548)2.27387029
88Absent hand (HP:0004050)2.27244761
89Abnormality of femoral epiphyses (HP:0006499)2.26820962
90Abnormality involving the epiphyses of the lower limbs (HP:0006500)2.26820962
91Gaze-evoked nystagmus (HP:0000640)2.26705653
92Muscle fiber atrophy (HP:0100295)2.25228181
93Limb hypertonia (HP:0002509)2.24348695
94Aplasia of the musculature (HP:0100854)2.22420258
95Pendular nystagmus (HP:0012043)2.22014414
96Neoplasm of the oral cavity (HP:0100649)2.19865481
97Supernumerary spleens (HP:0009799)2.18463051
98Cone-rod dystrophy (HP:0000548)2.18181108
99Lower limb hyperreflexia (HP:0002395)2.17584201
100Infertility (HP:0000789)2.17583967
101Disproportionate short-trunk short stature (HP:0003521)2.17490095
102Urethral obstruction (HP:0000796)2.12581963
103Sloping forehead (HP:0000340)2.11810293
104Abnormality of sulfur amino acid metabolism (HP:0004339)2.11443427
105Overlapping toe (HP:0001845)2.10707959
106Abnormality of the ileum (HP:0001549)2.10533494
107Fair hair (HP:0002286)2.09946892
108Hypercortisolism (HP:0001578)2.08545718
109Small intestinal stenosis (HP:0012848)2.08359386
110Duodenal stenosis (HP:0100867)2.08359386
111Germ cell neoplasia (HP:0100728)2.06105217
112* Aplasia/Hypoplasia of the macula (HP:0008059)2.05424101
113Abnormality of lateral ventricle (HP:0030047)2.03143125
114Intrahepatic cholestasis (HP:0001406)2.01666605
115Generalized hypopigmentation (HP:0007513)2.01661835
116Patchy hypopigmentation of hair (HP:0011365)2.01457821
117Cerebral hypomyelination (HP:0006808)2.01189617
118Pulmonary fibrosis (HP:0002206)2.00343882
119Rib fusion (HP:0000902)1.99836605
120Cystic hygroma (HP:0000476)1.99550140
121Abnormal ciliary motility (HP:0012262)1.98236719
122Bundle branch block (HP:0011710)1.96392532
123Autoimmune thrombocytopenia (HP:0001973)1.95754063
124Striae distensae (HP:0001065)1.95504948
125Maternal diabetes (HP:0009800)1.95449509
126Rough bone trabeculation (HP:0100670)1.95205125
127Horseshoe kidney (HP:0000085)1.95175697
128Supranuclear gaze palsy (HP:0000605)1.94040531
129Prostate neoplasm (HP:0100787)1.93979149
130Diminished movement (HP:0002374)1.93934815
131Colon cancer (HP:0003003)1.93238006
132Hypergonadotropic hypogonadism (HP:0000815)1.93124329
133Aplasia/Hypoplasia involving the musculature (HP:0001460)1.92972813
134Generalized aminoaciduria (HP:0002909)1.92228345
135Short tibia (HP:0005736)1.92193648
136Albinism (HP:0001022)1.92078052
137Bicornuate uterus (HP:0000813)1.90661417
138Abnormality of the septum pellucidum (HP:0007375)1.89899292
139Anomalous pulmonary venous return (HP:0010772)1.88795983
140Abnormality of the labia (HP:0000058)1.88653295
141* Aplasia/Hypoplasia affecting the retina (HP:0008061)1.88185864
142Bradykinesia (HP:0002067)1.87932056
143Aplasia/Hypoplasia of the tongue (HP:0010295)1.87285205
144* Aplasia/Hypoplasia affecting the fundus (HP:0008057)1.87007150
145Ectopic kidney (HP:0000086)1.86478441
146* Abnormality of the fovea (HP:0000493)1.85528458
147Entropion (HP:0000621)1.84570055
148Rickets (HP:0002748)1.83606956
149Hand muscle atrophy (HP:0009130)1.83598590
150Hip contracture (HP:0003273)1.83392948
151Abnormal auditory evoked potentials (HP:0006958)1.82688670
152Blue irides (HP:0000635)1.82175203
153Hypoglycemic coma (HP:0001325)1.81492284
154Progressive cerebellar ataxia (HP:0002073)1.81363407
155Primary amenorrhea (HP:0000786)1.81270480
156Proximal tubulopathy (HP:0000114)1.80839636
157Oral leukoplakia (HP:0002745)1.80694350
158Optic nerve hypoplasia (HP:0000609)1.80618223
159Thyroid carcinoma (HP:0002890)1.80222260
160Abnormal spermatogenesis (HP:0008669)1.79790267
161CNS hypomyelination (HP:0003429)1.78926938
162Abnormality of placental membranes (HP:0011409)1.78295900
163Amniotic constriction ring (HP:0009775)1.78295900
164Delayed puberty (HP:0000823)1.78249040
165Abnormality of the fingertips (HP:0001211)1.77672272
166Curly hair (HP:0002212)1.75469777
167Respiratory insufficiency due to defective ciliary clearance (HP:0200073)1.75020614
168Poor coordination (HP:0002370)1.74994964
169Hypogonadotrophic hypogonadism (HP:0000044)1.74799092
170Fibular aplasia (HP:0002990)1.74777442
171Aortic valve stenosis (HP:0001650)1.72126803
172Abnormality of the proximal phalanges of the hand (HP:0009834)1.70949148
173Abnormality of chromosome segregation (HP:0002916)1.70422480
174Retrobulbar optic neuritis (HP:0100654)1.69847636
175Optic neuritis (HP:0100653)1.69847636
176Lip pit (HP:0100267)1.69165508
177Death in infancy (HP:0001522)1.67712987
178Slender long bone (HP:0003100)1.67308267
179Myelodysplasia (HP:0002863)1.65928292
180Acute myeloid leukemia (HP:0004808)1.65713576

Predicted kinase interactions (KEA)

RankGene SetZ-score
1PINK16.32233887
2STK38L4.70176068
3LATS14.32817085
4LATS23.75647755
5MAP3K63.39939622
6PLK43.29234297
7TTK3.21820845
8NEK63.21037611
9ERBB42.81620596
10BRAF2.74907751
11NEK22.64974985
12BUB12.64512584
13KSR22.41524054
14CDC72.35752325
15ACVR1B2.33856386
16STK32.31698662
17DYRK32.22381374
18MAP3K92.14996833
19MET2.11116756
20MELK2.06075771
21TLK11.96588066
22TESK21.94545100
23CHEK21.77121079
24CDK81.72720967
25MST41.71588192
26TAOK11.65113588
27PLK11.63054002
28RAF11.60617616
29WEE11.59472364
30TAOK31.57656183
31NTRK21.52354448
32RPS6KA41.49268067
33MAP3K131.48889682
34KSR11.47409979
35ARAF1.39523980
36MUSK1.37622983
37CASK1.37431871
38TRIM281.36248084
39BRSK11.35862724
40SRPK11.30920183
41PLK31.25767701
42PTK21.23828433
43STK241.17669282
44DYRK21.17358173
45LRRK21.16750262
46AKT31.08121767
47NLK1.07716864
48AURKB1.06446117
49VRK11.05351207
50ABL21.04018369
51BCR1.03995121
52AURKA1.03615703
53EEF2K1.02479340
54PAK60.98010083
55STK380.96579893
56MOS0.94794021
57EIF2AK10.93847850
58MAP3K80.88817194
59CDK30.87997178
60INSRR0.87246933
61CDK70.87211445
62NTRK30.86283568
63BMPR20.84293167
64CSNK1G10.82660189
65EIF2AK30.82115449
66MAP2K70.80210163
67MAPK130.79817731
68BRSK20.78266447
69MAP3K40.78041052
70TNIK0.74944472
71CCNB10.72950774
72NEK10.72410302
73MAP3K50.70874591
74NUAK10.67655166
75PASK0.67376671
76CDK90.66890545
77CAMK1G0.66823239
78MARK30.65480644
79STK100.65125497
80BRD40.64350338
81CHEK10.63885613
82CDC42BPA0.63759805
83MTOR0.62976390
84MKNK20.62678876
85SGK20.62511363
86PKN10.61611128
87WNK10.59006575
88MAPK110.56178673
89CDK40.56078134
90PIK3CA0.55705486
91CSNK1D0.54269453
92PDK10.53561644
93PTK2B0.52990386
94ATM0.52106356
95PDPK10.52073403
96DMPK0.51904139
97CSNK1G30.51707071
98MAPKAPK30.50952891
99ZAK0.50256383
100CDK50.50046021
101ATR0.49011492
102CDK120.48525117
103EPHA30.46959706
104RPS6KB20.46184631
105NME10.45768668
106PRKCZ0.45591800
107AKT20.45316965
108NEK90.43628576
109PRKAA10.41281522
110EIF2AK20.39231400
111PRKG10.38690127
112TIE10.36934958
113CDK20.36323375
114GSK3B0.35897733
115CHUK0.34851755
116CSNK1E0.34764638
117BMPR1B0.33810492
118TNK20.33417236
119CSNK1G20.33380919
120CDK10.32318679
121PIM10.32187676
122STK390.32141192
123CAMK1D0.30355591
124FLT30.30115989
125MAPK10.30105082
126CSNK1A1L0.29194246
127ABL10.28107633
128ROCK10.27845138
129PRKAA20.26556764
130MAPK140.26030395
131PRKCI0.25807269
132LMTK20.25536819
133MAPKAPK50.25448886
134PRKACA0.24719681
135PAK10.24055696
136TESK10.23352542
137SGK4940.23282453
138SGK2230.23282453
139STK40.19829191
140MAPK100.19797912
141CSNK1A10.17210615
142PRKD30.16806690
143MAP2K40.16097267

Predicted pathways (KEGG)

RankGene SetZ-score
1Vitamin B6 metabolism_Homo sapiens_hsa007504.36679348
2RNA polymerase_Homo sapiens_hsa030204.00271619
3Cell cycle_Homo sapiens_hsa041103.94279973
4Basal transcription factors_Homo sapiens_hsa030223.63843638
5Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006013.33887436
6Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030083.08257821
7Homologous recombination_Homo sapiens_hsa034402.81876859
8RNA transport_Homo sapiens_hsa030132.81795399
9Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005332.75799129
10RNA degradation_Homo sapiens_hsa030182.75689237
11Fanconi anemia pathway_Homo sapiens_hsa034602.32964328
12DNA replication_Homo sapiens_hsa030302.28578280
13Mismatch repair_Homo sapiens_hsa034302.24837868
14p53 signaling pathway_Homo sapiens_hsa041152.16674978
15Base excision repair_Homo sapiens_hsa034102.15914456
16Nucleotide excision repair_Homo sapiens_hsa034201.98163598
17Pyrimidine metabolism_Homo sapiens_hsa002401.87073314
18Caffeine metabolism_Homo sapiens_hsa002321.87017643
19Proteasome_Homo sapiens_hsa030501.80190049
20Progesterone-mediated oocyte maturation_Homo sapiens_hsa049141.79930525
21Olfactory transduction_Homo sapiens_hsa047401.76505103
22Oocyte meiosis_Homo sapiens_hsa041141.75431476
23Gap junction_Homo sapiens_hsa045401.72521077
24Circadian rhythm_Homo sapiens_hsa047101.69998413
25Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.62137225
26Non-homologous end-joining_Homo sapiens_hsa034501.61106058
27mRNA surveillance pathway_Homo sapiens_hsa030151.56077710
28ABC transporters_Homo sapiens_hsa020101.53625011
29Phototransduction_Homo sapiens_hsa047441.51135026
30Regulation of autophagy_Homo sapiens_hsa041401.49778688
31Purine metabolism_Homo sapiens_hsa002301.47559500
32Lysine degradation_Homo sapiens_hsa003101.47502470
33Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.47098483
34Ether lipid metabolism_Homo sapiens_hsa005651.42769872
35Glycerophospholipid metabolism_Homo sapiens_hsa005641.35459288
36Folate biosynthesis_Homo sapiens_hsa007901.34290292
37Ovarian steroidogenesis_Homo sapiens_hsa049131.30469007
38Bile secretion_Homo sapiens_hsa049761.29896440
39Synaptic vesicle cycle_Homo sapiens_hsa047211.24543818
40Pancreatic cancer_Homo sapiens_hsa052121.24127791
41TGF-beta signaling pathway_Homo sapiens_hsa043501.21114111
42GABAergic synapse_Homo sapiens_hsa047271.14643567
43Epstein-Barr virus infection_Homo sapiens_hsa051691.10878652
44Linoleic acid metabolism_Homo sapiens_hsa005911.07340695
45Taste transduction_Homo sapiens_hsa047421.04200047
46Spliceosome_Homo sapiens_hsa030401.03884783
47Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.03288508
48Morphine addiction_Homo sapiens_hsa050321.03248063
49Aldosterone synthesis and secretion_Homo sapiens_hsa049250.99932528
50Colorectal cancer_Homo sapiens_hsa052100.99385216
51alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.97723090
52Pentose phosphate pathway_Homo sapiens_hsa000300.96711414
53Nicotine addiction_Homo sapiens_hsa050330.96692480
54Insulin secretion_Homo sapiens_hsa049110.95232787
55FoxO signaling pathway_Homo sapiens_hsa040680.94362710
56Renal cell carcinoma_Homo sapiens_hsa052110.94296478
57Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.93705521
58mTOR signaling pathway_Homo sapiens_hsa041500.93356243
59Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.90267041
60Prolactin signaling pathway_Homo sapiens_hsa049170.89898648
61MicroRNAs in cancer_Homo sapiens_hsa052060.88645738
62Herpes simplex infection_Homo sapiens_hsa051680.87928444
63Gastric acid secretion_Homo sapiens_hsa049710.87505803
64Dorso-ventral axis formation_Homo sapiens_hsa043200.86200041
65Other glycan degradation_Homo sapiens_hsa005110.84541750
66Arginine and proline metabolism_Homo sapiens_hsa003300.84132785
67Thyroid cancer_Homo sapiens_hsa052160.83331113
68Glycosaminoglycan degradation_Homo sapiens_hsa005310.82009399
69Hippo signaling pathway_Homo sapiens_hsa043900.80204786
70GnRH signaling pathway_Homo sapiens_hsa049120.80028471
71Choline metabolism in cancer_Homo sapiens_hsa052310.79501201
72SNARE interactions in vesicular transport_Homo sapiens_hsa041300.77732037
73Longevity regulating pathway - mammal_Homo sapiens_hsa042110.77058993
74Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.76536087
75Sphingolipid metabolism_Homo sapiens_hsa006000.75577711
76Small cell lung cancer_Homo sapiens_hsa052220.70530990
77Inositol phosphate metabolism_Homo sapiens_hsa005620.69922253
78NOD-like receptor signaling pathway_Homo sapiens_hsa046210.67643623
79Hepatitis B_Homo sapiens_hsa051610.63668665
80Cysteine and methionine metabolism_Homo sapiens_hsa002700.63066056
81Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.62901745
82Prostate cancer_Homo sapiens_hsa052150.59453828
83Melanoma_Homo sapiens_hsa052180.58301118
84Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.58197803
85Bladder cancer_Homo sapiens_hsa052190.57982956
86Fatty acid elongation_Homo sapiens_hsa000620.56861157
87HTLV-I infection_Homo sapiens_hsa051660.56231021
88Endometrial cancer_Homo sapiens_hsa052130.54615380
89Serotonergic synapse_Homo sapiens_hsa047260.53449838
90Thyroid hormone signaling pathway_Homo sapiens_hsa049190.52375603
91Vitamin digestion and absorption_Homo sapiens_hsa049770.52340837
92Circadian entrainment_Homo sapiens_hsa047130.50719624
93Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.47668431
94Apoptosis_Homo sapiens_hsa042100.45550754
95Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.44051132
96Melanogenesis_Homo sapiens_hsa049160.43601665
97Chronic myeloid leukemia_Homo sapiens_hsa052200.43387639
98MAPK signaling pathway_Homo sapiens_hsa040100.42824287
99Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.42565556
100Huntingtons disease_Homo sapiens_hsa050160.41832847
101Calcium signaling pathway_Homo sapiens_hsa040200.41528313
102ErbB signaling pathway_Homo sapiens_hsa040120.41307877
103Steroid biosynthesis_Homo sapiens_hsa001000.41259985
104Type I diabetes mellitus_Homo sapiens_hsa049400.40908157
105Vibrio cholerae infection_Homo sapiens_hsa051100.40885073
106Glycerolipid metabolism_Homo sapiens_hsa005610.38913818
107Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.37961356
108Intestinal immune network for IgA production_Homo sapiens_hsa046720.37462319
109NF-kappa B signaling pathway_Homo sapiens_hsa040640.36482905
110Non-small cell lung cancer_Homo sapiens_hsa052230.35716919
111One carbon pool by folate_Homo sapiens_hsa006700.35180325
112Notch signaling pathway_Homo sapiens_hsa043300.33865939
113Long-term depression_Homo sapiens_hsa047300.33753549
114Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.33505976
115cAMP signaling pathway_Homo sapiens_hsa040240.33199077
116Ras signaling pathway_Homo sapiens_hsa040140.33105634
117Arachidonic acid metabolism_Homo sapiens_hsa005900.31953766
118TNF signaling pathway_Homo sapiens_hsa046680.31935487
119Phosphatidylinositol signaling system_Homo sapiens_hsa040700.31809678
120Maturity onset diabetes of the young_Homo sapiens_hsa049500.31330792
121Protein digestion and absorption_Homo sapiens_hsa049740.29688360
122Shigellosis_Homo sapiens_hsa051310.28876188
123Viral carcinogenesis_Homo sapiens_hsa052030.28315552
124Cholinergic synapse_Homo sapiens_hsa047250.28036496
125Graft-versus-host disease_Homo sapiens_hsa053320.27519420
126Jak-STAT signaling pathway_Homo sapiens_hsa046300.27476948
127Salivary secretion_Homo sapiens_hsa049700.25978399
128Pathways in cancer_Homo sapiens_hsa052000.24371203
129Glutamatergic synapse_Homo sapiens_hsa047240.24359289
130Influenza A_Homo sapiens_hsa051640.24065344
131Thyroid hormone synthesis_Homo sapiens_hsa049180.23786053
132Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.23748039
133Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.23661041
134Histidine metabolism_Homo sapiens_hsa003400.22977882
135Arginine biosynthesis_Homo sapiens_hsa002200.22918363
136Amphetamine addiction_Homo sapiens_hsa050310.22807408
137Fatty acid biosynthesis_Homo sapiens_hsa000610.22609874
138Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.22386172
139cGMP-PKG signaling pathway_Homo sapiens_hsa040220.22181270
140Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.21586816
141VEGF signaling pathway_Homo sapiens_hsa043700.21229990
142Pancreatic secretion_Homo sapiens_hsa049720.20446681
143Rheumatoid arthritis_Homo sapiens_hsa053230.20357632
144Oxytocin signaling pathway_Homo sapiens_hsa049210.19540393
145Collecting duct acid secretion_Homo sapiens_hsa049660.19143834
146Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.18566614
147Estrogen signaling pathway_Homo sapiens_hsa049150.17808980
148Insulin signaling pathway_Homo sapiens_hsa049100.16999032
149Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.16818818
150Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.16807989
151Phospholipase D signaling pathway_Homo sapiens_hsa040720.16503260
152Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.16171416
153Glioma_Homo sapiens_hsa052140.16063976
154Phagosome_Homo sapiens_hsa041450.15864052
155Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.15851313
156Mineral absorption_Homo sapiens_hsa049780.15803967
157Adherens junction_Homo sapiens_hsa045200.15189040

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