SLC38A9

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1regulation of posttranscriptional gene silencing (GO:0060147)6.26654171
2regulation of gene silencing by miRNA (GO:0060964)6.26654171
3regulation of gene silencing by RNA (GO:0060966)6.26654171
4regulation of rhodopsin mediated signaling pathway (GO:0022400)5.90803648
5retinal cone cell development (GO:0046549)5.85135110
6rhodopsin mediated signaling pathway (GO:0016056)5.69852610
7regulation of nuclear cell cycle DNA replication (GO:0033262)5.16862820
8detection of light stimulus involved in sensory perception (GO:0050962)4.97487762
9detection of light stimulus involved in visual perception (GO:0050908)4.97487762
10chromatin remodeling at centromere (GO:0031055)4.54958536
11negative regulation of translation involved in gene silencing by miRNA (GO:0035278)4.48254491
12negative regulation of translation, ncRNA-mediated (GO:0040033)4.48254491
13regulation of translation, ncRNA-mediated (GO:0045974)4.48254491
14CENP-A containing nucleosome assembly (GO:0034080)4.46122978
15histone H3-K4 trimethylation (GO:0080182)4.33294699
16intestinal cholesterol absorption (GO:0030299)4.30082973
17regulation of hippo signaling (GO:0035330)4.29733461
18negative regulation of DNA-dependent DNA replication (GO:2000104)4.19121590
19eye photoreceptor cell development (GO:0042462)4.12719115
20photoreceptor cell development (GO:0042461)4.04635324
21photoreceptor cell maintenance (GO:0045494)4.02238212
22anterior/posterior axis specification, embryo (GO:0008595)3.91821126
23antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G3.84512047
24mast cell activation (GO:0045576)3.81922048
25somatic diversification of immune receptors via somatic mutation (GO:0002566)3.79153868
26somatic hypermutation of immunoglobulin genes (GO:0016446)3.79153868
27positive regulation of gamma-delta T cell activation (GO:0046645)3.69138100
28regulation of helicase activity (GO:0051095)3.66475573
29positive regulation of B cell differentiation (GO:0045579)3.62713502
30regulation of mesoderm development (GO:2000380)3.60758676
31eye photoreceptor cell differentiation (GO:0001754)3.58123337
32photoreceptor cell differentiation (GO:0046530)3.58123337
33DNA double-strand break processing (GO:0000729)3.57762913
34dorsal/ventral axis specification (GO:0009950)3.54654835
35snRNA transcription (GO:0009301)3.50788156
36DNA replication-independent nucleosome assembly (GO:0006336)3.50112912
37DNA replication-independent nucleosome organization (GO:0034724)3.50112912
38nonmotile primary cilium assembly (GO:0035058)3.50030855
39replicative senescence (GO:0090399)3.48528236
40positive regulation of granulocyte differentiation (GO:0030854)3.47730957
41histone exchange (GO:0043486)3.46872853
42pantothenate metabolic process (GO:0015939)3.46514332
43imidazole-containing compound metabolic process (GO:0052803)3.43437709
44tryptophan catabolic process (GO:0006569)3.41689123
45indole-containing compound catabolic process (GO:0042436)3.41689123
46indolalkylamine catabolic process (GO:0046218)3.41689123
47telomere maintenance via telomerase (GO:0007004)3.41267137
48negative regulation of mast cell activation (GO:0033004)3.41116054
49inner cell mass cell proliferation (GO:0001833)3.40765774
50axon ensheathment in central nervous system (GO:0032291)3.37643724
51central nervous system myelination (GO:0022010)3.37643724
52B cell receptor signaling pathway (GO:0050853)3.31849813
53DNA replication checkpoint (GO:0000076)3.30614248
54L-alpha-amino acid transmembrane transport (GO:1902475)3.30276872
55negative regulation of synaptic transmission, GABAergic (GO:0032229)3.19873031
56pre-miRNA processing (GO:0031054)3.19869030
57regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)3.19061243
58regulation of mitotic spindle checkpoint (GO:1903504)3.19061243
59histone-serine phosphorylation (GO:0035404)3.17616585
60transcription elongation from RNA polymerase I promoter (GO:0006362)3.16639970
61mast cell degranulation (GO:0043303)3.15758838
62mast cell activation involved in immune response (GO:0002279)3.15758838
63transcytosis (GO:0045056)3.15643028
64regulation of B cell receptor signaling pathway (GO:0050855)3.15564984
65kynurenine metabolic process (GO:0070189)3.15068511
66RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)3.14910715
67regulation of establishment of cell polarity (GO:2000114)3.11790963
68regulation of establishment or maintenance of cell polarity (GO:0032878)3.07284204
69regulation of platelet aggregation (GO:0090330)3.06623798
70activated T cell proliferation (GO:0050798)3.05734889
71retinal rod cell development (GO:0046548)3.03763673
72embryonic hemopoiesis (GO:0035162)3.02023441
73positive regulation of SMAD protein import into nucleus (GO:0060391)3.01714892
74basic amino acid transport (GO:0015802)3.00121174
75positive regulation of guanylate cyclase activity (GO:0031284)2.99926620
76detection of light stimulus (GO:0009583)2.99039979
77regulation of MHC class II biosynthetic process (GO:0045346)2.97046435
78chromatin silencing (GO:0006342)2.96359499
79presynaptic membrane assembly (GO:0097105)2.96246044
80positive regulation of cellular amide metabolic process (GO:0034250)2.95174079
81mitotic sister chromatid cohesion (GO:0007064)2.94605872
82mRNA cleavage (GO:0006379)2.93142977
83regulation of gene silencing (GO:0060968)2.93137766
84regulation of DNA endoreduplication (GO:0032875)2.91971097
85tryptophan metabolic process (GO:0006568)2.91680634
86double-strand break repair via homologous recombination (GO:0000724)2.91107009
87regulation of centrosome duplication (GO:0010824)2.90449980
88recombinational repair (GO:0000725)2.89588006
89transcription from mitochondrial promoter (GO:0006390)2.89076870
90L-fucose catabolic process (GO:0042355)2.88466490
91fucose catabolic process (GO:0019317)2.88466490
92L-fucose metabolic process (GO:0042354)2.88466490
93regulation of interferon-beta biosynthetic process (GO:0045357)2.87409773
94cellular response to thyroid hormone stimulus (GO:0097067)2.84856854
95phototransduction (GO:0007602)2.84630473
96acrosome reaction (GO:0007340)2.83615383
97nuclear pore complex assembly (GO:0051292)2.82196111
98definitive hemopoiesis (GO:0060216)2.81926743
99regulation of B cell differentiation (GO:0045577)2.80956498
100regulation of centrosome cycle (GO:0046605)2.80424660
101histone H3-K9 methylation (GO:0051567)2.79166046
102reciprocal meiotic recombination (GO:0007131)2.79156483
103reciprocal DNA recombination (GO:0035825)2.79156483
104GMP metabolic process (GO:0046037)2.78692978
105T-helper 1 type immune response (GO:0042088)2.77314768
106RNA-dependent DNA replication (GO:0006278)2.76776136
107termination of RNA polymerase I transcription (GO:0006363)2.74405163
108replication fork processing (GO:0031297)2.74064838
109import into cell (GO:0098657)2.74008682
110DNA replication-dependent nucleosome organization (GO:0034723)2.73998754
111DNA replication-dependent nucleosome assembly (GO:0006335)2.73998754
112positive regulation of action potential (GO:0045760)2.72872222
113cell morphogenesis involved in neuron differentiation (GO:0048667)2.72592383
114response to X-ray (GO:0010165)2.72395431
115negative regulation of gene expression, epigenetic (GO:0045814)2.71774752
116positive regulation of developmental pigmentation (GO:0048087)2.71664007
117oxidative demethylation (GO:0070989)2.71025409
118maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)2.70921228
119lymphoid progenitor cell differentiation (GO:0002320)2.70165621
120neutrophil activation involved in immune response (GO:0002283)2.69967117
121regulation of telomere maintenance via telomerase (GO:0032210)2.68745780
122detection of visible light (GO:0009584)2.68483712
123indolalkylamine metabolic process (GO:0006586)2.68405000
124NAD biosynthetic process (GO:0009435)2.68155362
125B cell homeostasis (GO:0001782)2.67961471
126nuclear pore organization (GO:0006999)2.66567446
127DNA catabolic process, exonucleolytic (GO:0000738)2.65531030
128T cell homeostasis (GO:0043029)2.65007356
129regulation of DNA methylation (GO:0044030)2.63810235
130megakaryocyte development (GO:0035855)2.63760192
131gonadal mesoderm development (GO:0007506)2.62917787
132mitochondrial RNA metabolic process (GO:0000959)2.62843193
133synaptic transmission, dopaminergic (GO:0001963)2.62464743
134nodal signaling pathway (GO:0038092)2.62217596
135regulation of inhibitory postsynaptic membrane potential (GO:0060080)2.61800668
136histone mRNA catabolic process (GO:0071044)2.61368022
137lymphangiogenesis (GO:0001946)2.60649789
138regulation of ruffle assembly (GO:1900027)2.60240084
139mature B cell differentiation (GO:0002335)2.59644778
140regulation of centriole replication (GO:0046599)2.59125167
141response to histamine (GO:0034776)2.58538065
142presynaptic membrane organization (GO:0097090)2.57824041
143regulation of voltage-gated calcium channel activity (GO:1901385)2.57498157
144sister chromatid cohesion (GO:0007062)2.57443946
145DNA replication initiation (GO:0006270)2.57274753
146positive regulation of excitatory postsynaptic membrane potential (GO:2000463)2.56690518
147embryonic foregut morphogenesis (GO:0048617)2.56419354
148negative regulation of dendrite development (GO:2000171)2.56355382
149peptidyl-lysine methylation (GO:0018022)2.55946625
150negative regulation of vascular endothelial growth factor receptor signaling pathway (GO:0030948)2.55432172
151visual perception (GO:0007601)2.55327701
152motile cilium assembly (GO:0044458)2.53285783
153embryonic axis specification (GO:0000578)2.52859307
154sensory perception of light stimulus (GO:0050953)2.52483431
155fatty acid elongation (GO:0030497)2.51946057
156regulation of double-strand break repair via homologous recombination (GO:0010569)2.51872748
157regulation of Wnt signaling pathway, planar cell polarity pathway (GO:2000095)2.51777985
158regulation of DNA-dependent DNA replication (GO:0090329)2.51245939
159telomere maintenance (GO:0000723)2.50876581
160regulation of histone H3-K9 methylation (GO:0051570)2.50855162
161regulation of penile erection (GO:0060405)2.50490076
162negative regulation of mitotic sister chromatid segregation (GO:0033048)2.50427845
163negative regulation of dendrite morphogenesis (GO:0050774)2.49732414
164phototransduction, visible light (GO:0007603)2.49323064
165peripheral nervous system neuron development (GO:0048935)2.47751421
166regulation of catecholamine uptake involved in synaptic transmission (GO:0051940)2.46398474
167regulation of dopamine uptake involved in synaptic transmission (GO:0051584)2.46398474
168regulation of action potential (GO:0098900)2.45014456
169neuron cell-cell adhesion (GO:0007158)2.44798189
170positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)2.43424224
171peptidyl-lysine trimethylation (GO:0018023)2.41702836
172microglial cell activation (GO:0001774)2.40195888
173regulation of guanylate cyclase activity (GO:0031282)2.40005015
174regulation of germinal center formation (GO:0002634)2.37188177
175protein localization to cilium (GO:0061512)2.37147574
176protein K48-linked deubiquitination (GO:0071108)2.36878081
177regulation of mast cell activation (GO:0033003)2.36585139
178lymphocyte homeostasis (GO:0002260)2.36346568
179protein K63-linked deubiquitination (GO:0070536)2.35867758
180regulation of regulatory T cell differentiation (GO:0045589)2.35385835
181negative regulation of B cell proliferation (GO:0030889)2.34377584
182positive regulation of respiratory burst (GO:0060267)2.33598720
183leukocyte homeostasis (GO:0001776)2.32526764
184positive regulation of neurotransmitter transport (GO:0051590)2.32018264
185myeloid cell activation involved in immune response (GO:0002275)2.31998205
186neurotransmitter-gated ion channel clustering (GO:0072578)2.31714899
187positive regulation of mitochondrial membrane permeability involved in apoptotic process (GO:19021102.31418102
188mitochondrial outer membrane permeabilization involved in programmed cell death (GO:1902686)2.31418102
189negative regulation of interleukin-17 production (GO:0032700)2.30990384
190B cell proliferation (GO:0042100)2.30110462
191Golgi to endosome transport (GO:0006895)2.29062174
192detection of external stimulus (GO:0009581)2.28476941
193striatum development (GO:0021756)2.28434828
194detection of abiotic stimulus (GO:0009582)2.27925933
195neutrophil activation (GO:0042119)2.26480474
196myeloid cell development (GO:0061515)2.25803923
197regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)2.25326293
198mannosylation (GO:0097502)2.24822442
199protein localization to synapse (GO:0035418)2.22255061

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human5.81600402
2FOXP3_17237761_ChIP-ChIP_TREG_Mouse4.01397560
3E2F4_17652178_ChIP-ChIP_JURKAT_Human3.98859278
4ZNF274_21170338_ChIP-Seq_K562_Hela3.53716473
5SALL1_21062744_ChIP-ChIP_HESCs_Human3.47207942
6GBX2_23144817_ChIP-Seq_PC3_Human3.25230465
7TAF15_26573619_Chip-Seq_HEK293_Human2.97516392
8BP1_19119308_ChIP-ChIP_Hs578T_Human2.80055016
9FOXM1_23109430_ChIP-Seq_U2OS_Human2.76328778
10KLF5_18264089_ChIP-ChIP_MESCs_Mouse2.69165828
11KLF4_18264089_ChIP-ChIP_MESCs_Mouse2.69165828
12KLF2_18264089_ChIP-ChIP_MESCs_Mouse2.69165828
13POU5F1_16153702_ChIP-ChIP_HESCs_Human2.68286996
14GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.61210943
15SCL_19346495_ChIP-Seq_HPC-7_Human2.57869220
16IRF8_21731497_ChIP-ChIP_J774_Mouse2.53962148
17MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.53917253
18IRF1_19129219_ChIP-ChIP_H3396_Human2.47914820
19BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse2.39038780
20FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.36491721
21IRF8_22096565_ChIP-ChIP_GC-B_Mouse2.31622527
22EZH2_22144423_ChIP-Seq_EOC_Human2.29028135
23MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.24745225
24POU3F2_20337985_ChIP-ChIP_501MEL_Human2.24637992
25IRF8_22096565_ChIP-ChIP_GC-B_Human2.24460115
26RUNX_20019798_ChIP-Seq_JUKART_Human2.20465412
27KDM5B_21448134_ChIP-Seq_MESCs_Mouse2.15001455
28ZFP57_27257070_Chip-Seq_ESCs_Mouse2.12327070
29TP63_19390658_ChIP-ChIP_HaCaT_Human2.07483152
30TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.00887048
31* VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.94648802
32NOTCH1_21737748_ChIP-Seq_TLL_Human1.94145556
33* IRF8_27001747_Chip-Seq_BMDM_Mouse1.92945723
34CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.86869028
35E2F1_21310950_ChIP-Seq_MCF-7_Human1.86799621
36KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.82507305
37* HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.81201397
38LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.78674313
39FLI1_27457419_Chip-Seq_LIVER_Mouse1.76577929
40CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.74502285
41P300_19829295_ChIP-Seq_ESCs_Human1.70928017
42CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.66070534
43PCGF2_27294783_Chip-Seq_ESCs_Mouse1.65041566
44SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.64218602
45VDR_22108803_ChIP-Seq_LS180_Human1.64159819
46SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.63022715
47SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.57478929
48ER_23166858_ChIP-Seq_MCF-7_Human1.55581178
49TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.51706800
50GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.49861776
51NANOG_18555785_Chip-Seq_ESCs_Mouse1.44028017
52STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.42005866
53BCAT_22108803_ChIP-Seq_LS180_Human1.41805197
54CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.40227859
55SUZ12_18555785_Chip-Seq_ESCs_Mouse1.39903998
56CTBP1_25329375_ChIP-Seq_LNCAP_Human1.39474006
57* SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.39197379
58CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.34684609
59ELK1_19687146_ChIP-ChIP_HELA_Human1.34231729
60EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.33602204
61PADI4_21655091_ChIP-ChIP_MCF-7_Human1.32539920
62EST1_17652178_ChIP-ChIP_JURKAT_Human1.32349654
63GABP_17652178_ChIP-ChIP_JURKAT_Human1.31967248
64P53_22387025_ChIP-Seq_ESCs_Mouse1.31898164
65* PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.30976177
66NANOG_16153702_ChIP-ChIP_HESCs_Human1.30815196
67IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.30731787
68CBP_20019798_ChIP-Seq_JUKART_Human1.30731787
69STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.29631751
70CMYC_18555785_Chip-Seq_ESCs_Mouse1.29114910
71SMAD4_21799915_ChIP-Seq_A2780_Human1.28976964
72E2F1_18555785_Chip-Seq_ESCs_Mouse1.28815058
73SUZ12_27294783_Chip-Seq_NPCs_Mouse1.26943507
74MYC_18940864_ChIP-ChIP_HL60_Human1.26542502
75AR_21572438_ChIP-Seq_LNCaP_Human1.26389370
76RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.26209288
77EWS_26573619_Chip-Seq_HEK293_Human1.25985129
78EZH2_27294783_Chip-Seq_NPCs_Mouse1.25532998
79FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.24088102
80FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.24062660
81LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.23738147
82IGF1R_20145208_ChIP-Seq_DFB_Human1.23490493
83GATA1_22025678_ChIP-Seq_K562_Human1.23303985
84PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.22647867
85FOXP3_21729870_ChIP-Seq_TREG_Human1.22554607
86NFE2_27457419_Chip-Seq_LIVER_Mouse1.21639941
87P300_18555785_Chip-Seq_ESCs_Mouse1.20233598
88REST_21632747_ChIP-Seq_MESCs_Mouse1.19439484
89SMAD_19615063_ChIP-ChIP_OVARY_Human1.19301430
90EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse1.18284432
91KLF1_20508144_ChIP-Seq_FETAL-LIVER-ERYTHROID_Mouse1.18012260
92RNF2_27304074_Chip-Seq_NSC_Mouse1.17364906
93EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.17270184
94TAL1_26923725_Chip-Seq_HPCs_Mouse1.16926045
95JARID2_20064375_ChIP-Seq_MESCs_Mouse1.16483190
96SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.16185188
97HOXB7_26014856_ChIP-Seq_BT474_Human1.16105076
98STAT3_18555785_Chip-Seq_ESCs_Mouse1.15538788
99RUNX1_27457419_Chip-Seq_LIVER_Mouse1.15492569
100CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.15288208
101VDR_23849224_ChIP-Seq_CD4+_Human1.15249184
102EGR1_23403033_ChIP-Seq_LIVER_Mouse1.14149633
103BMI1_23680149_ChIP-Seq_NPCS_Mouse1.13724575
104MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.12794599
105NMYC_18555785_Chip-Seq_ESCs_Mouse1.12486750
106SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.12197971
107* OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.11614186
108CTBP2_25329375_ChIP-Seq_LNCAP_Human1.11362224
109ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.10780104
110PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.10477848
111MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.09815701
112PRDM14_20953172_ChIP-Seq_ESCs_Human1.09385212
113STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.09003319
114E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.07817291
115PU1_27457419_Chip-Seq_LIVER_Mouse1.07503554
116FUS_26573619_Chip-Seq_HEK293_Human1.07049813
117VDR_24787735_ChIP-Seq_THP-1_Human1.06811794
118EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.05366809
119OCT4_18555785_Chip-Seq_ESCs_Mouse1.04966223
120ESR1_21235772_ChIP-Seq_MCF-7_Human1.04643615
121POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.04539272
122TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.04539272
123STAT4_19710469_ChIP-ChIP_TH1__Mouse1.04355059
124* AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.04129592
125NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.03908792
126GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.03722021
127SOX2_18555785_Chip-Seq_ESCs_Mouse1.03485539
128TBX3_20139965_ChIP-Seq_ESCs_Mouse1.03456204
129STAT3_23295773_ChIP-Seq_U87_Human1.03314328
130TBX3_20139965_ChIP-Seq_MESCs_Mouse1.02760253
131HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.02751714
132AR_25329375_ChIP-Seq_VCAP_Human1.02422599
133* TCF4_23295773_ChIP-Seq_U87_Human1.02370334
134CTCF_18555785_Chip-Seq_ESCs_Mouse1.02300425
135CRX_20693478_ChIP-Seq_RETINA_Mouse1.01581779
136UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.01568400
137Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.01523358
138NELFA_20434984_ChIP-Seq_ESCs_Mouse1.01467836
139GATA1_19941827_ChIP-Seq_MEL_Mouse1.01057748
140SOX2_16153702_ChIP-ChIP_HESCs_Human1.00807756
141FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.00548058
142POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.00263813
143KLF5_20875108_ChIP-Seq_MESCs_Mouse0.99600840
144CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse0.99096017
145KLF4_18555785_Chip-Seq_ESCs_Mouse0.96593048
146PCGF2_27294783_Chip-Seq_NPCs_Mouse0.95988693
147MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse0.95561226
148SMAD1_18555785_Chip-Seq_ESCs_Mouse0.95373785
149SPI1_23547873_ChIP-Seq_NB4_Human0.95342778
150AHR_22903824_ChIP-Seq_MCF-7_Human0.95228209
151AR_21909140_ChIP-Seq_LNCAP_Human0.94639874
152ZFX_18555785_Chip-Seq_ESCs_Mouse0.94606895
153STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse0.94158023
154SPI1_23127762_ChIP-Seq_K562_Human0.93685382
155TCF4_22108803_ChIP-Seq_LS180_Human0.93494336
156SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse0.93153150
157NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human0.92449034
158TCF3_18692474_ChIP-Seq_MESCs_Mouse0.88238369
159FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human0.87946480
160PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse0.87490171
161FOXO1_23066095_ChIP-Seq_LIVER_Mouse0.86867890
162ARNT_22903824_ChIP-Seq_MCF-7_Human0.86146511
163SMAD4_21741376_ChIP-Seq_EPCs_Human0.84692689
164JARID1A_20064375_ChIP-Seq_MESCs_Mouse0.82485924
165MYC_19030024_ChIP-ChIP_MESCs_Mouse0.81773486
166SMAD3_21741376_ChIP-Seq_EPCs_Human0.81693731
167SMAD2/3_21741376_ChIP-Seq_EPCs_Human0.81511409
168GATA4_25053715_ChIP-Seq_YYC3_Human0.80517667
169PIAS1_25552417_ChIP-Seq_VCAP_Human0.80377558
170MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human0.80254629
171YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse0.78922507

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008057_abnormal_DNA_replication5.00229130
2MP0002254_reproductive_system_inflammat4.26349782
3MP0001986_abnormal_taste_sensitivity3.94012002
4MP0005551_abnormal_eye_electrophysiolog3.70436824
5MP0010094_abnormal_chromosome_stability3.31348277
6MP0003693_abnormal_embryo_hatching3.04938741
7MP0003941_abnormal_skin_development2.98927308
8MP0003880_abnormal_central_pattern2.93546708
9MP0001835_abnormal_antigen_presentation2.86443995
10MP0003011_delayed_dark_adaptation2.83923212
11MP0004147_increased_porphyrin_level2.69448315
12MP0003718_maternal_effect2.63442606
13MP0002653_abnormal_ependyma_morphology2.52309463
14MP0001666_abnormal_nutrient_absorption2.49901757
15MP0002638_abnormal_pupillary_reflex2.45214869
16MP0004957_abnormal_blastocyst_morpholog2.44871939
17MP0005076_abnormal_cell_differentiation2.39241819
18MP0000383_abnormal_hair_follicle2.34976941
19MP0003890_abnormal_embryonic-extraembry2.34316314
20MP0005174_abnormal_tail_pigmentation2.31003348
21MP0003195_calcinosis2.26324841
22MP0005423_abnormal_somatic_nervous2.24643075
23MP0005253_abnormal_eye_physiology2.23192666
24MP0005671_abnormal_response_to2.20883990
25MP0003656_abnormal_erythrocyte_physiolo2.19502395
26MP0001968_abnormal_touch/_nociception2.19184336
27MP0006054_spinal_hemorrhage2.11444612
28MP0000569_abnormal_digit_pigmentation2.11007199
29MP0005409_darkened_coat_color2.09952251
30MP0003111_abnormal_nucleus_morphology2.07965559
31MP0008058_abnormal_DNA_repair2.06026316
32MP0003077_abnormal_cell_cycle2.05096568
33MP0001800_abnormal_humoral_immune1.91316952
34MP0003787_abnormal_imprinting1.90645202
35MP0001529_abnormal_vocalization1.87115215
36MP0002736_abnormal_nociception_after1.86807859
37MP0003937_abnormal_limbs/digits/tail_de1.84565620
38MP0000920_abnormal_myelination1.81837420
39MP0009046_muscle_twitch1.80464574
40MP0001984_abnormal_olfaction1.79916662
41MP0001293_anophthalmia1.71291230
42MP0003119_abnormal_digestive_system1.71165474
43MP0005377_hearing/vestibular/ear_phenot1.69376505
44MP0003878_abnormal_ear_physiology1.69376505
45MP0000427_abnormal_hair_cycle1.69055293
46MP0005410_abnormal_fertilization1.65855310
47MP0002272_abnormal_nervous_system1.62959437
48MP0002735_abnormal_chemical_nociception1.60728687
49MP0002452_abnormal_antigen_presenting1.60707816
50MP0009384_cardiac_valve_regurgitation1.59719163
51MP0001790_abnormal_immune_system1.58781430
52MP0005387_immune_system_phenotype1.58781430
53MP0005365_abnormal_bile_salt1.58369627
54MP0000015_abnormal_ear_pigmentation1.57865147
55MP0002229_neurodegeneration1.55528606
56MP0006072_abnormal_retinal_apoptosis1.53760534
57MP0002095_abnormal_skin_pigmentation1.53487777
58MP0002098_abnormal_vibrissa_morphology1.51877480
59MP0003724_increased_susceptibility_to1.50497643
60MP0002723_abnormal_immune_serum1.49832736
61MP0005000_abnormal_immune_tolerance1.49247636
62MP0006276_abnormal_autonomic_nervous1.48655114
63MP0002420_abnormal_adaptive_immunity1.47724070
64MP0001730_embryonic_growth_arrest1.46280579
65MP0004270_analgesia1.45738897
66MP0001905_abnormal_dopamine_level1.45600601
67MP0002067_abnormal_sensory_capabilities1.45076686
68MP0000465_gastrointestinal_hemorrhage1.45066709
69MP0001819_abnormal_immune_cell1.44077616
70MP0005670_abnormal_white_adipose1.43179035
71MP0003183_abnormal_peptide_metabolism1.42843593
72MP0002064_seizures1.41725524
73MP0002419_abnormal_innate_immunity1.40437638
74MP0009672_abnormal_birth_weight1.40169961
75MP0002166_altered_tumor_susceptibility1.39591096
76MP0005464_abnormal_platelet_physiology1.38029232
77MP0008877_abnormal_DNA_methylation1.37475340
78MP0001672_abnormal_embryogenesis/_devel1.37218115
79MP0005380_embryogenesis_phenotype1.37218115
80MP0009745_abnormal_behavioral_response1.35089003
81MP0002398_abnormal_bone_marrow1.34396222
82MP0002734_abnormal_mechanical_nocicepti1.34035958
83MP0001486_abnormal_startle_reflex1.33788896
84MP0004142_abnormal_muscle_tone1.31965591
85MP0008961_abnormal_basal_metabolism1.31584230
86MP0005195_abnormal_posterior_eye1.30209752
87MP0002148_abnormal_hypersensitivity_rea1.29875629
88MP0003950_abnormal_plasma_membrane1.28604114
89MP0005075_abnormal_melanosome_morpholog1.27033376
90MP0002084_abnormal_developmental_patter1.25111246
91MP0010678_abnormal_skin_adnexa1.24298055
92MP0001188_hyperpigmentation1.23219056
93MP0004859_abnormal_synaptic_plasticity1.22464238
94MP0009697_abnormal_copulation1.21591634
95MP0003984_embryonic_growth_retardation1.21581401
96MP0005025_abnormal_response_to1.21165124
97MP0000716_abnormal_immune_system1.21140697
98MP0002088_abnormal_embryonic_growth/wei1.19285594
99MP0002396_abnormal_hematopoietic_system1.19206264
100MP0002697_abnormal_eye_size1.18805411
101MP0000689_abnormal_spleen_morphology1.18291738
102MP0003136_yellow_coat_color1.18262666
103MP0002572_abnormal_emotion/affect_behav1.17386105
104MP0008569_lethality_at_weaning1.17152345
105MP0001324_abnormal_eye_pigmentation1.17055689
106MP0004264_abnormal_extraembryonic_tissu1.15607773
107MP0008932_abnormal_embryonic_tissue1.14472492
108MP0004197_abnormal_fetal_growth/weight/1.13947570
109MP0003635_abnormal_synaptic_transmissio1.13634638
110MP0005083_abnormal_biliary_tract1.12676966
111MP0006035_abnormal_mitochondrial_morpho1.11004619
112MP0002086_abnormal_extraembryonic_tissu1.10648061
113MP0002085_abnormal_embryonic_tissue1.07828286
114MP0003646_muscle_fatigue1.07213546
115MP0004133_heterotaxia1.06484831
116MP0009703_decreased_birth_body1.06393413
117MP0000647_abnormal_sebaceous_gland1.06347706
118MP0003690_abnormal_glial_cell1.05593084
119MP0003763_abnormal_thymus_physiology1.04551069
120MP0001502_abnormal_circadian_rhythm1.02932325
121MP0002111_abnormal_tail_morphology1.02293447
122MP0002009_preneoplasia1.01683930
123MP0000685_abnormal_immune_system1.00922264
124MP0005395_other_phenotype1.00636695
125MP0005645_abnormal_hypothalamus_physiol0.99546135
126MP0001697_abnormal_embryo_size0.99379476
127MP0001970_abnormal_pain_threshold0.97484505
128MP0002429_abnormal_blood_cell0.97203548
129MP0004381_abnormal_hair_follicle0.95392007
130MP0002722_abnormal_immune_system0.94682462
131MP0001286_abnormal_eye_development0.94366857
132MP0002752_abnormal_somatic_nervous0.94073777
133MP0003567_abnormal_fetal_cardiomyocyte0.93981558
134MP0008260_abnormal_autophagy0.93807976
135MP0005220_abnormal_exocrine_pancreas0.93331763
136MP0005386_behavior/neurological_phenoty0.91306125
137MP0004924_abnormal_behavior0.91306125
138MP0002090_abnormal_vision0.90901030
139MP0002882_abnormal_neuron_morphology0.89532028
140MP0001853_heart_inflammation0.89355086
141MP0004742_abnormal_vestibular_system0.88214466
142MP0006292_abnormal_olfactory_placode0.85611892
143MP0002210_abnormal_sex_determination0.85492105
144MP0002080_prenatal_lethality0.85356110
145MP0005397_hematopoietic_system_phenotyp0.85323524
146MP0001545_abnormal_hematopoietic_system0.85323524
147MP0002796_impaired_skin_barrier0.85209499
148MP0002063_abnormal_learning/memory/cond0.84494159
149MP0002132_abnormal_respiratory_system0.83219026
150MP0002822_catalepsy0.82903513
151MP0004808_abnormal_hematopoietic_stem0.82352652
152MP0001119_abnormal_female_reproductive0.82160907
153MP0002006_tumorigenesis0.81676886
154MP0005646_abnormal_pituitary_gland0.81143934
155MP0003698_abnormal_male_reproductive0.81077799
156MP0002405_respiratory_system_inflammati0.80352755
157MP0005310_abnormal_salivary_gland0.80141783
158MP0009785_altered_susceptibility_to0.79981091
159MP0009840_abnormal_foam_cell0.79311268
160MP0009115_abnormal_fat_cell0.79151512
161MP0002733_abnormal_thermal_nociception0.79072325
162MP0000428_abnormal_craniofacial_morphol0.78903541
163MP0003172_abnormal_lysosome_physiology0.78003284
164MP0003868_abnormal_feces_composition0.76031523
165MP0002925_abnormal_cardiovascular_devel0.75031321
166MP0001929_abnormal_gametogenesis0.74596848
167MP0002751_abnormal_autonomic_nervous0.74415468
168MP0001191_abnormal_skin_condition0.74094213
169MP0001849_ear_inflammation0.72931445
170MP0009278_abnormal_bone_marrow0.72848375
171MP0000432_abnormal_head_morphology0.71883355
172MP0008770_decreased_survivor_rate0.70390354
173MP0000358_abnormal_cell_content/0.70074116
174MP0000653_abnormal_sex_gland0.69678234
175MP0005167_abnormal_blood-brain_barrier0.69665494
176MP0003699_abnormal_female_reproductive0.68619739
177MP0001145_abnormal_male_reproductive0.68281110
178MP0010307_abnormal_tumor_latency0.68031723
179MP0001485_abnormal_pinna_reflex0.67998993
180MP0002933_joint_inflammation0.67549275
181MP0000631_abnormal_neuroendocrine_gland0.67461796
182MP0000350_abnormal_cell_proliferation0.67227549
183MP0000313_abnormal_cell_death0.66514412
184MP0000470_abnormal_stomach_morphology0.65250350
185MP0003943_abnormal_hepatobiliary_system0.64939737
186MP0002092_abnormal_eye_morphology0.64734990
187MP0001873_stomach_inflammation0.64151142
188MP0010352_gastrointestinal_tract_polyps0.63461275
189MP0005391_vision/eye_phenotype0.63270236

Predicted human phenotypes

RankGene SetZ-score
1Congenital stationary night blindness (HP:0007642)8.32877352
2Abnormal rod and cone electroretinograms (HP:0008323)4.46723243
3Absent rod-and cone-mediated responses on ERG (HP:0007688)4.34174854
4Bony spicule pigmentary retinopathy (HP:0007737)4.24031353
5Birth length less than 3rd percentile (HP:0003561)3.66340463
6Attenuation of retinal blood vessels (HP:0007843)3.66096160
7Decreased central vision (HP:0007663)3.39453253
8Chromosomal breakage induced by crosslinking agents (HP:0003221)3.28910594
9Pigmentary retinal degeneration (HP:0001146)3.23863598
10Colon cancer (HP:0003003)3.20337361
11Protruding tongue (HP:0010808)3.19731340
12Abnormality of the heme biosynthetic pathway (HP:0010472)3.17339843
13Abnormality of the renal collecting system (HP:0004742)3.13010253
14Abnormal hair whorl (HP:0010721)3.11044994
15Panhypogammaglobulinemia (HP:0003139)3.10946875
16Abnormality of macular pigmentation (HP:0008002)3.10892858
17Absent radius (HP:0003974)3.10787257
18Gastrointestinal stroma tumor (HP:0100723)3.10017774
19Thyroiditis (HP:0100646)3.06013717
20Chromsome breakage (HP:0040012)3.04657540
21Agammaglobulinemia (HP:0004432)3.02817593
22Retrobulbar optic neuritis (HP:0100654)3.00171294
23Optic neuritis (HP:0100653)3.00171294
24Abolished electroretinogram (ERG) (HP:0000550)2.99389112
25Dyschromatopsia (HP:0007641)2.98227028
26Hypothermia (HP:0002045)2.97989573
27Meckel diverticulum (HP:0002245)2.97112213
28Aplasia/Hypoplasia of the uvula (HP:0010293)2.94154043
29Abnormality of chromosome stability (HP:0003220)2.94101012
30Myositis (HP:0100614)2.92982677
31Febrile seizures (HP:0002373)2.91438548
32Medial flaring of the eyebrow (HP:0010747)2.91398357
33Abnormality of the ileum (HP:0001549)2.90851441
34Hypoplasia of the pons (HP:0012110)2.90530875
35Bilateral microphthalmos (HP:0007633)2.90180481
36Clumsiness (HP:0002312)2.88838786
37Duplicated collecting system (HP:0000081)2.85326335
38Absent/shortened dynein arms (HP:0200106)2.84412760
39Dynein arm defect of respiratory motile cilia (HP:0012255)2.84412760
40Recurrent sinusitis (HP:0011108)2.83317697
41Elevated erythrocyte sedimentation rate (HP:0003565)2.81870473
42Severe visual impairment (HP:0001141)2.77643393
43Recurrent abscess formation (HP:0002722)2.75529571
44Aplasia involving forearm bones (HP:0009822)2.75351200
45Absent forearm bone (HP:0003953)2.75351200
46Abnormality of the pons (HP:0007361)2.74427407
47Epileptic encephalopathy (HP:0200134)2.70508406
48Central scotoma (HP:0000603)2.69880097
49Recurrent bacterial skin infections (HP:0005406)2.67483262
50Gait imbalance (HP:0002141)2.66398877
51Congenital primary aphakia (HP:0007707)2.62239235
52Clubbing of toes (HP:0100760)2.61981897
53Respiratory insufficiency due to defective ciliary clearance (HP:0200073)2.60063022
54Breast hypoplasia (HP:0003187)2.59988991
55Nephrogenic diabetes insipidus (HP:0009806)2.57967367
56Photophobia (HP:0000613)2.57479614
57Pancreatic cysts (HP:0001737)2.56991135
58Genetic anticipation (HP:0003743)2.55368106
59Ectopic kidney (HP:0000086)2.53929323
60Abnormality of the preputium (HP:0100587)2.47471606
61Increased cerebral lipofuscin (HP:0011813)2.45070056
62Stenosis of the external auditory canal (HP:0000402)2.43013281
63Sloping forehead (HP:0000340)2.39672119
64Meningitis (HP:0001287)2.38444046
65Retinitis pigmentosa (HP:0000510)2.37943463
66Small intestinal stenosis (HP:0012848)2.36969745
67Duodenal stenosis (HP:0100867)2.36969745
68True hermaphroditism (HP:0010459)2.33077882
69Recurrent viral infections (HP:0004429)2.29679651
70Ependymoma (HP:0002888)2.29519196
71Parakeratosis (HP:0001036)2.29288740
72Chronic mucocutaneous candidiasis (HP:0002728)2.27563594
73Recurrent cutaneous fungal infections (HP:0011370)2.27563594
74Hyperventilation (HP:0002883)2.27402123
75Increased corneal curvature (HP:0100692)2.26414269
76Keratoconus (HP:0000563)2.26414269
77Anal stenosis (HP:0002025)2.23926977
78Retinal dysplasia (HP:0007973)2.21294685
79Abnormality of the axillary hair (HP:0100134)2.20484258
80Abnormality of secondary sexual hair (HP:0009888)2.20484258
81Vasculitis (HP:0002633)2.20099630
82Colitis (HP:0002583)2.17874034
83Macular degeneration (HP:0000608)2.17473043
84Homocystinuria (HP:0002156)2.15529982
85Abnormality of homocysteine metabolism (HP:0010919)2.15529982
86B lymphocytopenia (HP:0010976)2.15199498
87Abnormality of B cell number (HP:0010975)2.15199498
88Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)2.14753625
89Recurrent skin infections (HP:0001581)2.14370331
90Breast aplasia (HP:0100783)2.13864184
91Recurrent bronchitis (HP:0002837)2.13236018
92Ureteral duplication (HP:0000073)2.12735503
93Inability to walk (HP:0002540)2.12680025
94Abnormality of alanine metabolism (HP:0010916)2.11132721
95Hyperalaninemia (HP:0003348)2.11132721
96Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.11132721
97Decreased electroretinogram (ERG) amplitude (HP:0000654)2.09999865
98Arthropathy (HP:0003040)2.09622438
99Encephalitis (HP:0002383)2.08785634
100Orchitis (HP:0100796)2.07782540
101Chronic hepatic failure (HP:0100626)2.07543786
102Widely spaced teeth (HP:0000687)2.07335207
103Pendular nystagmus (HP:0012043)2.06929030
104Prolonged bleeding time (HP:0003010)2.06633535
105Impulsivity (HP:0100710)2.06399581
106Patellar aplasia (HP:0006443)2.04720337
107Abnormality of the duodenum (HP:0002246)2.03058654
108Glioma (HP:0009733)2.01948854
109Optic disc pallor (HP:0000543)2.01906829
110Decreased circulating renin level (HP:0003351)2.01216009
111Abnormality of serum amino acid levels (HP:0003112)2.00365409
112Cupped ear (HP:0000378)1.97778348
113Pancreatic fibrosis (HP:0100732)1.96762346
114Parkinsonism with favorable response to dopaminergic medication (HP:0002548)1.96454565
115Chronic otitis media (HP:0000389)1.96023666
116Aplasia/Hypoplasia involving the musculature (HP:0001460)1.95808078
117Septo-optic dysplasia (HP:0100842)1.95732374
118Poor coordination (HP:0002370)1.95706600
119Type II lissencephaly (HP:0007260)1.95660563
120Scotoma (HP:0000575)1.94988959
121Stomach cancer (HP:0012126)1.94969494
122Absent eyebrow (HP:0002223)1.94878623
123Cellular immunodeficiency (HP:0005374)1.93391913
124Recurrent fungal infections (HP:0002841)1.93278121
125Type II diabetes mellitus (HP:0005978)1.93257893
126Capillary hemangiomas (HP:0005306)1.92175075
127Cystic liver disease (HP:0006706)1.91988413
128Lymphopenia (HP:0001888)1.91794126
129Inflammation of the large intestine (HP:0002037)1.90575912
130Intestinal fistula (HP:0100819)1.90046392
131Focal motor seizures (HP:0011153)1.89370464
132Increased neuronal autofluorescent lipopigment (HP:0002074)1.87733781
133Rectovaginal fistula (HP:0000143)1.86881940
134Rectal fistula (HP:0100590)1.86881940
135White forelock (HP:0002211)1.86835844
136Progressive inability to walk (HP:0002505)1.85827859
137Abnormal delayed hypersensitivity skin test (HP:0002963)1.85585828
138Absent thumb (HP:0009777)1.84905475
139Fair hair (HP:0002286)1.82874034
140Genital tract atresia (HP:0001827)1.82178952
141Fatigue (HP:0012378)1.81494208
142Triphalangeal thumb (HP:0001199)1.81099262
143Multiple enchondromatosis (HP:0005701)1.80984220
144Severe combined immunodeficiency (HP:0004430)1.80190472
145Petechiae (HP:0000967)1.79959853
146Abnormality of macrophages (HP:0004311)1.79378767
147Carpal bone hypoplasia (HP:0001498)1.79227270
148Skull defect (HP:0001362)1.78758438
149Morphological abnormality of the middle ear (HP:0008609)1.78178734
150Recurrent pneumonia (HP:0006532)1.77281745
151Gaze-evoked nystagmus (HP:0000640)1.76824295
152Aplasia/Hypoplasia of the patella (HP:0006498)1.76466957
153Aplasia/Hypoplasia of the breasts (HP:0010311)1.76263389
154Abnormal respiratory epithelium morphology (HP:0012253)1.73388132
155Abnormal respiratory motile cilium morphology (HP:0005938)1.73388132
156Abnormality of midbrain morphology (HP:0002418)1.73280080
157Molar tooth sign on MRI (HP:0002419)1.73280080
158Small hand (HP:0200055)1.73212481
159Vaginal atresia (HP:0000148)1.72598976
160Aplasia/Hypoplasia of the lens (HP:0008063)1.71037945
161Slow saccadic eye movements (HP:0000514)1.70216852
162Abnormality of pyrimidine metabolism (HP:0004353)1.69626742
163Chronic obstructive pulmonary disease (HP:0006510)1.68942942
164Obstructive lung disease (HP:0006536)1.68942942
165Abnormal respiratory motile cilium physiology (HP:0012261)1.68043649
166Chronic sinusitis (HP:0011109)1.67882673
167Absent hand (HP:0004050)1.67618500
168Aplasia/Hypoplasia of the tibia (HP:0005772)1.67454773
169Mediastinal lymphadenopathy (HP:0100721)1.65562739
170Abnormality of cells of the lymphoid lineage (HP:0012140)1.65280462
171Vaginal fistula (HP:0004320)1.63931662
172Abnormality of the carotid arteries (HP:0005344)1.62842913
173Abnormal biliary tract physiology (HP:0012439)1.61084612
174Bile duct proliferation (HP:0001408)1.61084612
175Horseshoe kidney (HP:0000085)1.60389692
176Astigmatism (HP:0000483)1.59870950
177Clitoromegaly (HP:0000057)1.59164972
178Myelomeningocele (HP:0002475)1.57660351
179Pancreatic islet-cell hyperplasia (HP:0004510)1.57654331
180Bifid tongue (HP:0010297)1.57181600
181Anencephaly (HP:0002323)1.56537871

Predicted kinase interactions (KEA)

RankGene SetZ-score
1AKT35.94715963
2FRK4.12690567
3ACVR1B3.88030711
4ZAK3.74742268
5TNIK3.44612302
6MUSK2.99325813
7RIPK42.50229928
8BLK2.45225566
9SRPK12.39877767
10MAP4K12.37368034
11CASK2.34104278
12GRK12.29627220
13TSSK62.25825616
14CCNB12.16830073
15KIT2.16178006
16YES12.02964463
17CDK192.02718273
18GRK71.97818632
19MAPK151.97756617
20TXK1.97591564
21SIK31.87522777
22CDC71.87265769
23MAP3K121.84639297
24EIF2AK31.81284055
25MAP3K141.79997158
26SIK21.77590136
27IRAK41.77444778
28TEC1.73829762
29FES1.59534477
30WNK31.55314975
31DYRK31.54505261
32MAP3K131.54439996
33TTK1.54319467
34SYK1.54059507
35BRSK21.53211417
36NLK1.51485855
37MAPKAPK51.48966805
38CAMK1G1.42130955
39BTK1.41232859
40TIE11.39981283
41IRAK31.37876084
42TGFBR11.34801476
43TAF11.32872426
44MAPK71.31424693
45CSF1R1.30244588
46NEK61.27196755
47PLK31.25667254
48STK391.24422782
49MAPK131.24006295
50OXSR11.23887986
51PLK41.23673077
52TRIM281.22533570
53NEK21.20276687
54STK38L1.19823273
55PBK1.18700583
56MARK31.16594961
57LATS11.16354922
58BMPR21.13755282
59SGK21.13161271
60PKN11.13015478
61CHEK21.12644518
62MELK1.12428669
63MATK1.12313085
64SIK11.12236116
65PRPF4B1.10830928
66LYN1.10603960
67MKNK21.08870859
68SGK2231.07643125
69SGK4941.07643125
70LCK1.07327814
71CLK11.06686888
72TNK21.00239188
73NME10.99989380
74MAP2K70.99978473
75RPS6KA40.97910960
76ZAP700.97250228
77CDK30.97016000
78ATR0.94943500
79PLK10.92579766
80CDK120.91489752
81LMTK20.88449328
82CAMK10.88290391
83CAMK1D0.87750978
84EPHA20.87685805
85BMX0.87567961
86PDK20.86032521
87BMPR1B0.85952825
88IRAK20.84972644
89MAPK120.83993509
90KDR0.83719744
91STK380.83007865
92WNK10.82641753
93MAP4K20.79547818
94PNCK0.78031576
95IKBKE0.77512686
96ADRBK20.76816166
97TYK20.75476130
98STK30.74417329
99CHUK0.73699608
100BRD40.72884084
101EIF2AK20.72408000
102MKNK10.71893796
103HCK0.70491119
104TAOK30.70462665
105EIF2AK10.69746868
106RPS6KA60.68013078
107CSNK1G30.65493912
108STK160.63978702
109MAP3K60.63004032
110PRKCQ0.62923214
111MAP2K60.62404767
112TLK10.62023309
113IKBKB0.60227973
114TGFBR20.59062038
115MAP3K40.58797532
116JAK30.57767912
117NTRK30.57524970
118CDK60.56811466
119PDK10.55090393
120CSK0.53157192
121CSNK1G20.52775157
122VRK10.51798361
123ATM0.51174399
124ITK0.48448522
125IRAK10.48420223
126BUB10.48302446
127NUAK10.46987204
128RPS6KC10.46616217
129RPS6KL10.46616217
130FYN0.45282783
131BRAF0.45253316
132CSNK1A1L0.44968732
133ADRBK10.44259916
134SGK30.44055118
135GRK60.42898122
136CDK90.42864253
137TBK10.42128145
138PRKG10.41974508
139PDGFRB0.40912552
140DYRK1A0.40866408
141CDK50.39844305
142CHEK10.39683666
143MET0.37501425
144JAK10.36313436
145ERBB20.36231554
146RPS6KA50.35877648
147MAPK80.35673297
148ICK0.35405562
149TRPM70.35048213
150PDPK10.34939850
151CAMK2A0.34628780
152MTOR0.33462382
153INSRR0.32859125
154CDK20.32135952
155RPS6KB20.31997279
156MAP3K70.31605166
157CAMKK20.30455762
158MST40.29616313
159PRKAA20.28815459
160CSNK1G10.28195535
161CDK10.28112340
162HIPK20.28100378
163AURKB0.27436371
164STK40.26971242
165TRIB30.26575224
166EGFR0.25605282
167MAPK10.25457924
168MAP3K100.24484379
169CDK40.22750336
170WNK40.21759660
171PAK40.21611237
172PRKAA10.21336965

Predicted pathways (KEGG)

RankGene SetZ-score
1Phototransduction_Homo sapiens_hsa047447.63364711
2Homologous recombination_Homo sapiens_hsa034403.27129965
3Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.96264261
4Mismatch repair_Homo sapiens_hsa034302.93957118
5Primary immunodeficiency_Homo sapiens_hsa053402.74765387
6Steroid biosynthesis_Homo sapiens_hsa001002.64947800
7Fanconi anemia pathway_Homo sapiens_hsa034602.62713842
8Vitamin digestion and absorption_Homo sapiens_hsa049772.35781975
9Fat digestion and absorption_Homo sapiens_hsa049752.32444773
10Olfactory transduction_Homo sapiens_hsa047402.29141609
11DNA replication_Homo sapiens_hsa030302.26488819
12B cell receptor signaling pathway_Homo sapiens_hsa046622.06801134
13SNARE interactions in vesicular transport_Homo sapiens_hsa041301.97789334
14Base excision repair_Homo sapiens_hsa034101.95062853
15Morphine addiction_Homo sapiens_hsa050321.92023354
16Nicotine addiction_Homo sapiens_hsa050331.88104554
17Sphingolipid metabolism_Homo sapiens_hsa006001.85106814
18Glycerolipid metabolism_Homo sapiens_hsa005611.84737613
19Synaptic vesicle cycle_Homo sapiens_hsa047211.80663300
20Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.79519396
21Histidine metabolism_Homo sapiens_hsa003401.74785714
22RNA polymerase_Homo sapiens_hsa030201.66269233
23alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.64862818
24Cell cycle_Homo sapiens_hsa041101.64073258
25Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.62811489
26Non-homologous end-joining_Homo sapiens_hsa034501.62604374
27Protein digestion and absorption_Homo sapiens_hsa049741.61592709
28Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.58827919
29Hematopoietic cell lineage_Homo sapiens_hsa046401.55398501
30Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.55007543
31GABAergic synapse_Homo sapiens_hsa047271.48163352
32Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.47986387
33RNA transport_Homo sapiens_hsa030131.47585685
34Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.46134811
35Glutamatergic synapse_Homo sapiens_hsa047241.43761880
36One carbon pool by folate_Homo sapiens_hsa006701.39765184
37Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.38495873
38Circadian entrainment_Homo sapiens_hsa047131.37654498
39Lysine degradation_Homo sapiens_hsa003101.37071514
40Serotonergic synapse_Homo sapiens_hsa047261.33830895
41Selenocompound metabolism_Homo sapiens_hsa004501.30863163
42Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.30701754
43Phosphatidylinositol signaling system_Homo sapiens_hsa040701.25846500
44Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.25812886
45Linoleic acid metabolism_Homo sapiens_hsa005911.24482717
46Steroid hormone biosynthesis_Homo sapiens_hsa001401.23856402
47Primary bile acid biosynthesis_Homo sapiens_hsa001201.23347684
48Cysteine and methionine metabolism_Homo sapiens_hsa002701.21835704
49Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.20214207
50Measles_Homo sapiens_hsa051621.19838170
51mRNA surveillance pathway_Homo sapiens_hsa030151.17303095
52Collecting duct acid secretion_Homo sapiens_hsa049661.16988095
53Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.14162243
54Salivary secretion_Homo sapiens_hsa049701.13996462
55Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.13771432
56Taste transduction_Homo sapiens_hsa047421.13705482
57Fatty acid elongation_Homo sapiens_hsa000621.13661968
58Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.11810413
59Tryptophan metabolism_Homo sapiens_hsa003801.10215539
60Rheumatoid arthritis_Homo sapiens_hsa053231.08982193
61Tuberculosis_Homo sapiens_hsa051521.08809101
62Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.06149642
63Calcium signaling pathway_Homo sapiens_hsa040201.05849925
64Osteoclast differentiation_Homo sapiens_hsa043801.05374602
65Cholinergic synapse_Homo sapiens_hsa047251.05091280
66Systemic lupus erythematosus_Homo sapiens_hsa053221.03458478
67Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045501.02765664
68Intestinal immune network for IgA production_Homo sapiens_hsa046721.00556767
69Nucleotide excision repair_Homo sapiens_hsa034201.00145864
70Pentose and glucuronate interconversions_Homo sapiens_hsa000400.96880710
71T cell receptor signaling pathway_Homo sapiens_hsa046600.95132572
72Ether lipid metabolism_Homo sapiens_hsa005650.95038033
73Oxidative phosphorylation_Homo sapiens_hsa001900.94853229
74Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.94525567
75Retinol metabolism_Homo sapiens_hsa008300.93760349
76Caffeine metabolism_Homo sapiens_hsa002320.93275775
77NOD-like receptor signaling pathway_Homo sapiens_hsa046210.92899724
78p53 signaling pathway_Homo sapiens_hsa041150.92634525
79Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.91533829
80Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.88635666
81Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.88182729
82Dopaminergic synapse_Homo sapiens_hsa047280.87677522
83Chemokine signaling pathway_Homo sapiens_hsa040620.87447971
84NF-kappa B signaling pathway_Homo sapiens_hsa040640.84215610
85TGF-beta signaling pathway_Homo sapiens_hsa043500.83982858
86Basal cell carcinoma_Homo sapiens_hsa052170.83874807
87Inositol phosphate metabolism_Homo sapiens_hsa005620.83441410
88Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.82506951
89Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.81665200
90Starch and sucrose metabolism_Homo sapiens_hsa005000.81186761
91Leishmaniasis_Homo sapiens_hsa051400.80853522
92Spliceosome_Homo sapiens_hsa030400.80230062
93Aldosterone synthesis and secretion_Homo sapiens_hsa049250.79361241
94Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.79062827
95Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.78667655
96Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.78432902
97Toll-like receptor signaling pathway_Homo sapiens_hsa046200.78345481
98Hippo signaling pathway_Homo sapiens_hsa043900.76328953
99Antigen processing and presentation_Homo sapiens_hsa046120.76176424
100Cyanoamino acid metabolism_Homo sapiens_hsa004600.75781524
101Phagosome_Homo sapiens_hsa041450.74379583
102Renin secretion_Homo sapiens_hsa049240.74061572
103Ovarian steroidogenesis_Homo sapiens_hsa049130.73503401
104Influenza A_Homo sapiens_hsa051640.70926610
105Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.70031075
106Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.69724848
107Lysosome_Homo sapiens_hsa041420.68518117
108Platelet activation_Homo sapiens_hsa046110.68110292
109Alzheimers disease_Homo sapiens_hsa050100.67948647
110Propanoate metabolism_Homo sapiens_hsa006400.64964639
111ABC transporters_Homo sapiens_hsa020100.64211916
112Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.64130061
113Chemical carcinogenesis_Homo sapiens_hsa052040.63602804
114Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.62771357
115cAMP signaling pathway_Homo sapiens_hsa040240.62728447
116Sphingolipid signaling pathway_Homo sapiens_hsa040710.61983151
117Staphylococcus aureus infection_Homo sapiens_hsa051500.61800876
118Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.61085100
119Long-term depression_Homo sapiens_hsa047300.60862264
120Other glycan degradation_Homo sapiens_hsa005110.60598175
121MicroRNAs in cancer_Homo sapiens_hsa052060.59793277
122Renin-angiotensin system_Homo sapiens_hsa046140.59459415
123Jak-STAT signaling pathway_Homo sapiens_hsa046300.59215488
124Oxytocin signaling pathway_Homo sapiens_hsa049210.58342503
125Parkinsons disease_Homo sapiens_hsa050120.57556555
126Arachidonic acid metabolism_Homo sapiens_hsa005900.57502820
127Drug metabolism - other enzymes_Homo sapiens_hsa009830.57456073
128Alcoholism_Homo sapiens_hsa050340.57014291
129Gastric acid secretion_Homo sapiens_hsa049710.56678094
130Pancreatic secretion_Homo sapiens_hsa049720.56044019
131Malaria_Homo sapiens_hsa051440.55935915
132Phospholipase D signaling pathway_Homo sapiens_hsa040720.55727666
133Hedgehog signaling pathway_Homo sapiens_hsa043400.54657978
134Long-term potentiation_Homo sapiens_hsa047200.54232584
135Cardiac muscle contraction_Homo sapiens_hsa042600.54193833
136RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.52762985
137Notch signaling pathway_Homo sapiens_hsa043300.51626227
138Glycerophospholipid metabolism_Homo sapiens_hsa005640.51493470
139Autoimmune thyroid disease_Homo sapiens_hsa053200.51300826
140Dorso-ventral axis formation_Homo sapiens_hsa043200.51080256
141Transcriptional misregulation in cancer_Homo sapiens_hsa052020.50665973
142Amphetamine addiction_Homo sapiens_hsa050310.50070349
143Vitamin B6 metabolism_Homo sapiens_hsa007500.48533171
144Pyrimidine metabolism_Homo sapiens_hsa002400.46538368
145Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.45843600
146African trypanosomiasis_Homo sapiens_hsa051430.45701274
147Viral carcinogenesis_Homo sapiens_hsa052030.45664800
148Adherens junction_Homo sapiens_hsa045200.45098665
149Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.44579183
150Herpes simplex infection_Homo sapiens_hsa051680.44063299
151cGMP-PKG signaling pathway_Homo sapiens_hsa040220.44004045
152Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.43750923
153Colorectal cancer_Homo sapiens_hsa052100.42984211
154Purine metabolism_Homo sapiens_hsa002300.42884698
155Glycosaminoglycan degradation_Homo sapiens_hsa005310.42373678
156Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.42188240
157RNA degradation_Homo sapiens_hsa030180.41900637
158Pertussis_Homo sapiens_hsa051330.41542250
159Insulin secretion_Homo sapiens_hsa049110.41044994
160Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.40942640
161MAPK signaling pathway_Homo sapiens_hsa040100.39977219
162Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.39328365
163Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.38014521
164Basal transcription factors_Homo sapiens_hsa030220.37760936
165Huntingtons disease_Homo sapiens_hsa050160.36797918
166Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.36754164
167Sulfur relay system_Homo sapiens_hsa041220.35581235
168Wnt signaling pathway_Homo sapiens_hsa043100.34040135
169Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.33324617
170Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.31546240
171beta-Alanine metabolism_Homo sapiens_hsa004100.30707874
172Hepatitis C_Homo sapiens_hsa051600.30210440
173Proteasome_Homo sapiens_hsa030500.29942947
174Pyruvate metabolism_Homo sapiens_hsa006200.28743589
175Metabolic pathways_Homo sapiens_hsa011000.28032916
176Melanoma_Homo sapiens_hsa052180.26871559

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