SLC39A1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the zinc-iron permease family. The encoded protein is localized to the cell membrane and acts as a zinc uptake transporter. This gene has been linked to prostate cancer, breast cancer, and Alzheimer's disease. Alternative splicing results in multiple transcript variants. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1COPI coating of Golgi vesicle (GO:0048205)5.30010893
2Golgi transport vesicle coating (GO:0048200)5.30010893
3positive regulation of protein kinase C signaling (GO:0090037)5.07092730
4protein retention in ER lumen (GO:0006621)4.84638486
5maintenance of protein localization in endoplasmic reticulum (GO:0035437)4.81359688
6DNA unwinding involved in DNA replication (GO:0006268)4.22765726
7protein maturation by protein folding (GO:0022417)4.21662295
8short-term memory (GO:0007614)4.15984171
9endothelium development (GO:0003158)4.13221976
10pentose-phosphate shunt (GO:0006098)4.06513869
11proline biosynthetic process (GO:0006561)3.97121223
12establishment of integrated proviral latency (GO:0075713)3.90993562
13negative regulation of execution phase of apoptosis (GO:1900118)3.88134636
14NADPH regeneration (GO:0006740)3.83757409
15negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)3.74381941
16negative regulation of fibroblast growth factor receptor signaling pathway (GO:0040037)3.68496210
17fibrinolysis (GO:0042730)3.66605755
18L-serine metabolic process (GO:0006563)3.58205612
19protein complex localization (GO:0031503)3.57567868
20DNA strand elongation involved in DNA replication (GO:0006271)3.49550453
21establishment of viral latency (GO:0019043)3.48772787
22glucose catabolic process (GO:0006007)3.48112283
23omega-hydroxylase P450 pathway (GO:0097267)3.47381502
24DNA strand elongation (GO:0022616)3.44646955
25branch elongation of an epithelium (GO:0060602)3.43943738
26organ growth (GO:0035265)3.39618118
27peptidyl-arginine omega-N-methylation (GO:0035247)3.35245888
28planar cell polarity pathway involved in neural tube closure (GO:0090179)3.34639012
29nucleobase-containing small molecule interconversion (GO:0015949)3.31951906
30regulation of mammary gland epithelial cell proliferation (GO:0033599)3.31916019
31nuclear envelope reassembly (GO:0031468)3.30549734
32mitotic nuclear envelope reassembly (GO:0007084)3.30549734
33cellular protein complex localization (GO:0034629)3.28208440
34regulation of translational fidelity (GO:0006450)3.27035885
35retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)3.23443978
36heterochromatin organization (GO:0070828)3.23415458
37histone arginine methylation (GO:0034969)3.23037065
38negative regulation of leukocyte chemotaxis (GO:0002689)3.18985586
39mitotic chromosome condensation (GO:0007076)3.10309243
40radial glial cell differentiation (GO:0060019)3.09709414
41pinocytosis (GO:0006907)3.03005080
42glucose 6-phosphate metabolic process (GO:0051156)2.99983521
43telomere maintenance via semi-conservative replication (GO:0032201)2.97806033
44positive regulation of monocyte chemotaxis (GO:0090026)2.97272892
45regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)2.96768028
46superoxide anion generation (GO:0042554)2.95127172
47GMP metabolic process (GO:0046037)2.93659563
48amyloid precursor protein catabolic process (GO:0042987)2.93564241
49positive regulation of Cdc42 GTPase activity (GO:0043089)2.92039368
50protein heterotrimerization (GO:0070208)2.89983661
51positive regulation of inositol phosphate biosynthetic process (GO:0060732)2.88537326
52regulation of interleukin-8 secretion (GO:2000482)2.87490676
53epithelial cell-cell adhesion (GO:0090136)2.87175513
54spermatid nucleus differentiation (GO:0007289)2.85797031
55skin morphogenesis (GO:0043589)2.84572230
56regulation of translational termination (GO:0006449)2.83824007
57bone remodeling (GO:0046849)2.80895071
58nephron epithelium development (GO:0072009)2.80321471
59import into cell (GO:0098657)2.79462939
60retina vasculature morphogenesis in camera-type eye (GO:0061299)2.79437745
61L-alpha-amino acid transmembrane transport (GO:1902475)2.77992333
62barbed-end actin filament capping (GO:0051016)2.77722781
63microglial cell activation (GO:0001774)2.77006991
64GDP-mannose metabolic process (GO:0019673)2.76525406
65protein localization to endosome (GO:0036010)2.75213327
66regulation of pigment cell differentiation (GO:0050932)2.75133844
67metanephric tubule development (GO:0072170)2.74850519
68metanephric nephron tubule development (GO:0072234)2.74850519
69positive regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S tr2.74682044
70paraxial mesoderm development (GO:0048339)2.74405484
71blood coagulation, intrinsic pathway (GO:0007597)2.73591366
72proline metabolic process (GO:0006560)2.73464452
73eosinophil chemotaxis (GO:0048245)2.73349299
74adherens junction assembly (GO:0034333)2.72722281
75regulation of mononuclear cell migration (GO:0071675)2.72376102
76positive regulation of steroid hormone secretion (GO:2000833)2.72144593
77metanephric nephron epithelium development (GO:0072243)2.71120673
78regulation of fibrinolysis (GO:0051917)2.70900196
79formation of translation preinitiation complex (GO:0001731)2.70317397
80pentose metabolic process (GO:0019321)2.69699106
81response to interferon-alpha (GO:0035455)2.69571120
82negative regulation of nitric oxide biosynthetic process (GO:0045019)2.69370273
83negative regulation of peptidyl-threonine phosphorylation (GO:0010801)2.68405401
84spliceosomal tri-snRNP complex assembly (GO:0000244)2.68125145
85metanephric epithelium development (GO:0072207)2.66454592
86axis elongation (GO:0003401)2.65914410
87mesenchymal cell differentiation involved in kidney development (GO:0072161)2.65743564
88mesenchymal cell differentiation involved in renal system development (GO:2001012)2.65743564
89endoplasmic reticulum calcium ion homeostasis (GO:0032469)2.65110889
90response to folic acid (GO:0051593)2.63971789
91sequestering of extracellular ligand from receptor (GO:0035581)2.61398899
92cellular response to virus (GO:0098586)2.60152504
93negative regulation of nitric-oxide synthase activity (GO:0051001)2.59867275
94cell-substrate adherens junction assembly (GO:0007045)2.58415222
95focal adhesion assembly (GO:0048041)2.58415222
96peptidyl-arginine methylation (GO:0018216)2.58228453
97peptidyl-arginine N-methylation (GO:0035246)2.58228453
98nuclear pore complex assembly (GO:0051292)2.57316780
99desmosome organization (GO:0002934)2.56894283
100protein localization to chromosome, centromeric region (GO:0071459)2.56736430
101response to peptidoglycan (GO:0032494)2.56644324
102regulation of monocyte chemotaxis (GO:0090025)2.55993097
103regulation of mitochondrial translation (GO:0070129)2.55940801
104negative regulation of wound healing (GO:0061045)2.55922822
105definitive hemopoiesis (GO:0060216)2.55903356
106glycosphingolipid catabolic process (GO:0046479)2.55758630
107endocrine hormone secretion (GO:0060986)2.55093555
108deoxyribonucleoside monophosphate metabolic process (GO:0009162)2.55051733
109positive regulation of smooth muscle cell migration (GO:0014911)2.54909238
110monocyte chemotaxis (GO:0002548)2.52982923
111regulation of inositol phosphate biosynthetic process (GO:0010919)2.52148680
112melanin metabolic process (GO:0006582)2.52069219
113nucleotide-sugar biosynthetic process (GO:0009226)2.49398877
114negative regulation of cell fate specification (GO:0009996)2.49189163
115DNA replication initiation (GO:0006270)2.48799146
116regulation of protein kinase C signaling (GO:0090036)2.48072538
117negative regulation of ligase activity (GO:0051352)2.47972198
118negative regulation of ubiquitin-protein transferase activity (GO:0051444)2.47972198
119folic acid metabolic process (GO:0046655)2.47191639
120negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)2.47190359
121regulation of branching involved in salivary gland morphogenesis (GO:0060693)2.46650079
122facial nerve structural organization (GO:0021612)2.45980569
123neutrophil activation involved in immune response (GO:0002283)2.45043686
124epithelial cell differentiation involved in prostate gland development (GO:0060742)2.44748801
125apoptotic process involved in morphogenesis (GO:0060561)2.44648741
126negative regulation of blood coagulation (GO:0030195)2.44158371
127negative regulation of hemostasis (GO:1900047)2.44158371
128positive regulation of interferon-alpha production (GO:0032727)2.43948424
1294-hydroxyproline metabolic process (GO:0019471)2.43514972
130branching involved in salivary gland morphogenesis (GO:0060445)2.43291608
131monosaccharide biosynthetic process (GO:0046364)2.42930258
132mesenchymal-epithelial cell signaling (GO:0060638)2.42149362
133negative regulation of coagulation (GO:0050819)2.41845527
134NADH metabolic process (GO:0006734)2.41010946
135activation of signaling protein activity involved in unfolded protein response (GO:0006987)2.40225475
136serine family amino acid biosynthetic process (GO:0009070)2.39957168
137dichotomous subdivision of an epithelial terminal unit (GO:0060600)2.39647209
138protein localization to kinetochore (GO:0034501)2.39607385
139regulation of fibroblast growth factor receptor signaling pathway (GO:0040036)2.39558674
140ribosome assembly (GO:0042255)2.39397797
141mitotic metaphase plate congression (GO:0007080)2.38957323
142positive regulation of acute inflammatory response (GO:0002675)2.38184700
143endothelial cell morphogenesis (GO:0001886)2.37807590
144positive regulation of nuclease activity (GO:0032075)2.36083124
145positive regulation of systemic arterial blood pressure (GO:0003084)2.35749190
146limb bud formation (GO:0060174)2.35547934
147negative regulation of release of cytochrome c from mitochondria (GO:0090201)2.35534592
148establishment of apical/basal cell polarity (GO:0035089)2.35190488
149maternal placenta development (GO:0001893)2.35023113
150eosinophil migration (GO:0072677)2.34097339
151retina layer formation (GO:0010842)2.33775981
152GTP biosynthetic process (GO:0006183)2.33446288
153negative regulation of viral entry into host cell (GO:0046597)2.33411803
154response to interferon-beta (GO:0035456)2.32504071
155positive regulation of calcium ion import (GO:0090280)2.31833923
156mitochondrial fusion (GO:0008053)2.31488210
157presynaptic membrane assembly (GO:0097105)2.31130973
158negative regulation of viral genome replication (GO:0045071)2.30845820
159peptidyl-proline hydroxylation (GO:0019511)2.30128777
160gap junction assembly (GO:0016264)2.29855158
161cell differentiation involved in metanephros development (GO:0072202)2.29791438
162positive regulation of extrinsic apoptotic signaling pathway in absence of ligand (GO:2001241)2.29745753
163G-protein coupled receptor signaling pathway coupled to cGMP nucleotide second messenger (GO:00071992.29264100
164folic acid-containing compound biosynthetic process (GO:0009396)2.28934403
165regulation of interferon-alpha production (GO:0032647)2.28460652
166convergent extension (GO:0060026)2.28156101
167anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:02.27752798
168purine ribonucleotide transport (GO:0015868)2.27474144
169regulation of T-helper 1 cell differentiation (GO:0045625)2.27236258
170glycolipid catabolic process (GO:0019377)2.27124590
171apoptotic cell clearance (GO:0043277)2.26551159
172mitotic sister chromatid segregation (GO:0000070)2.26359976
173protein hydroxylation (GO:0018126)2.26310082
174basement membrane organization (GO:0071711)2.26260103
175activation of Rac GTPase activity (GO:0032863)2.25980428
176cell-substrate junction assembly (GO:0007044)2.25565875
177tRNA aminoacylation for protein translation (GO:0006418)2.25564846
178dermatan sulfate biosynthetic process (GO:0030208)2.24254090
179phagocytosis, engulfment (GO:0006911)2.23815893
180positive regulation of type I interferon-mediated signaling pathway (GO:0060340)2.23725614
181regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S transition 2.23648077
182extracellular negative regulation of signal transduction (GO:1900116)2.20811133
183extracellular regulation of signal transduction (GO:1900115)2.20811133
184wound healing, spreading of epidermal cells (GO:0035313)2.20010661
185Notch signaling involved in heart development (GO:0061314)2.19441717
186modulation by organism of defense response of other organism involved in symbiotic interaction (GO:02.18605769
187positive regulation by organism of defense response of other organism involved in symbiotic interact2.18605769
188modulation by symbiont of host immune response (GO:0052553)2.18605769
189positive regulation by symbiont of host defense response (GO:0052509)2.18605769
190modulation by symbiont of host defense response (GO:0052031)2.18605769
191modulation by organism of immune response of other organism involved in symbiotic interaction (GO:002.18605769
192protein heterotetramerization (GO:0051290)2.16904520
193Leydig cell differentiation (GO:0033327)2.16083986
194negative regulation of Ras GTPase activity (GO:0034261)2.16011076
195T-helper 1 type immune response (GO:0042088)2.15692551
196positive regulation of syncytium formation by plasma membrane fusion (GO:0060143)2.15208899
197negative regulation of platelet activation (GO:0010544)2.14828780
198regulation of macrophage chemotaxis (GO:0010758)2.14168272
199neuron remodeling (GO:0016322)2.13829027

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human4.44253228
2BP1_19119308_ChIP-ChIP_Hs578T_Human3.74768020
3EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.35120099
4TRIM28_21343339_ChIP-Seq_HEK293_Human3.29139856
5MYC_18555785_ChIP-Seq_MESCs_Mouse2.93512964
6SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.88905651
7TP63_17297297_ChIP-ChIP_HaCaT_Human2.73425428
8HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.64042216
9ZNF263_19887448_ChIP-Seq_K562_Human2.54652669
10WT1_19549856_ChIP-ChIP_CCG9911_Human2.53967328
11IRF8_22096565_ChIP-ChIP_GC-B_Human2.53104733
12CDX2_19796622_ChIP-Seq_MESCs_Mouse2.52155395
13AR_21572438_ChIP-Seq_LNCaP_Human2.36820326
14EED_16625203_ChIP-ChIP_MESCs_Mouse2.36120325
15TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.27696876
16MYC_18358816_ChIP-ChIP_MESCs_Mouse2.22427477
17JARID2_20064375_ChIP-Seq_MESCs_Mouse2.19882104
18FOXM1_23109430_ChIP-Seq_U2OS_Human2.15835482
19PPARG_19300518_ChIP-PET_3T3-L1_Mouse2.11647462
20MYC_19079543_ChIP-ChIP_MESCs_Mouse2.08501907
21CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.07849182
22MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.05206859
23* MYC_19030024_ChIP-ChIP_MESCs_Mouse2.01804813
24ZFP281_18358816_ChIP-ChIP_MESCs_Mouse2.00956614
25SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.00682771
26IRF8_21731497_ChIP-ChIP_J774_Mouse1.99240576
27SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.96819060
28NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.95476952
29* NELFA_20434984_ChIP-Seq_ESCs_Mouse1.94968697
30FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.92946247
31CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.90155284
32POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.89307874
33SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.89273970
34JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.87771859
35SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.87658754
36SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.87635814
37EZH2_18974828_ChIP-Seq_MESCs_Mouse1.86189319
38RNF2_18974828_ChIP-Seq_MESCs_Mouse1.86189319
39PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.85687309
40DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.85571338
41RACK7_27058665_Chip-Seq_MCF-7_Human1.85338384
42GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.84476158
43* ELK3_25401928_ChIP-Seq_HUVEC_Human1.80099908
44PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.79561878
45* XRN2_22483619_ChIP-Seq_HELA_Human1.76655981
46ZFX_18555785_ChIP-Seq_MESCs_Mouse1.76418474
47SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.75134411
48EZH2_22144423_ChIP-Seq_EOC_Human1.72563718
49EZH2_27304074_Chip-Seq_ESCs_Mouse1.72112101
50E2F1_18555785_ChIP-Seq_MESCs_Mouse1.70817493
51LXR_22292898_ChIP-Seq_THP-1_Human1.68317951
52CLOCK_20551151_ChIP-Seq_293T_Human1.67742387
53RARG_19884340_ChIP-ChIP_MEFs_Mouse1.67602221
54THAP11_20581084_ChIP-Seq_MESCs_Mouse1.66164664
55IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.65212009
56CBX2_27304074_Chip-Seq_ESCs_Mouse1.64384175
57TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.64184159
58NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.62753081
59RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.62733732
60TAF15_26573619_Chip-Seq_HEK293_Human1.62479769
61IRF8_27001747_Chip-Seq_BMDM_Mouse1.62471576
62AR_21909140_ChIP-Seq_LNCAP_Human1.61510330
63RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.60978662
64KLF4_18555785_ChIP-Seq_MESCs_Mouse1.59637433
65KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.58436799
66TP53_18474530_ChIP-ChIP_U2OS_Human1.58048401
67NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.58008437
68KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.57824072
69KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.57824072
70KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.57824072
71TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.56743842
72JARID2_20075857_ChIP-Seq_MESCs_Mouse1.56314280
73NANOG_18555785_ChIP-Seq_MESCs_Mouse1.50991483
74CREB1_15753290_ChIP-ChIP_HEK293T_Human1.49786696
75KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.48741692
76DCP1A_22483619_ChIP-Seq_HELA_Human1.48033956
77VDR_24787735_ChIP-Seq_THP-1_Human1.45969244
78FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.45904624
79MYC_22102868_ChIP-Seq_BL_Human1.45045874
80ESR1_15608294_ChIP-ChIP_MCF-7_Human1.44979170
81ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.44111435
82CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.44024332
83TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.43536339
84Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.43436896
85GATA2_21666600_ChIP-Seq_HMVEC_Human1.40889495
86MYCN_18555785_ChIP-Seq_MESCs_Mouse1.40657407
87IKZF1_21737484_ChIP-ChIP_HCT116_Human1.40355074
88CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.39986608
89CDX2_20551321_ChIP-Seq_CACO-2_Human1.39191844
90ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.38862717
91VDR_21846776_ChIP-Seq_THP-1_Human1.38352656
92BMI1_23680149_ChIP-Seq_NPCS_Mouse1.37539063
93VDR_22108803_ChIP-Seq_LS180_Human1.37321117
94KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.37147574
95HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.36119425
96CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.35334523
97NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.35280748
98NRF2_20460467_ChIP-Seq_MEFs_Mouse1.35280748
99PIAS1_25552417_ChIP-Seq_VCAP_Human1.34984615
100EGR1_23403033_ChIP-Seq_LIVER_Mouse1.33718723
101SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.33716883
102SRY_22984422_ChIP-ChIP_TESTIS_Rat1.33589061
103ZFP57_27257070_Chip-Seq_ESCs_Mouse1.33479625
104POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.32885770
105GBX2_23144817_ChIP-Seq_PC3_Human1.32836224
106CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.32785732
107STAT3_1855785_ChIP-Seq_MESCs_Mouse1.32623115
108HIF1A_21447827_ChIP-Seq_MCF-7_Human1.31656667
109POU5F1_16153702_ChIP-ChIP_HESCs_Human1.30901426
110ATF3_27146783_Chip-Seq_COLON_Human1.29959217
111PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.29431856
112FLI1_27457419_Chip-Seq_LIVER_Mouse1.29419685
113ETS1_20019798_ChIP-Seq_JURKAT_Human1.29412099
114TET1_21451524_ChIP-Seq_MESCs_Mouse1.29264739
115SOX2_20726797_ChIP-Seq_SW620_Human1.29147178
116NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.29052796
117SUZ12_27294783_Chip-Seq_ESCs_Mouse1.28560237
118TP53_20018659_ChIP-ChIP_R1E_Mouse1.27716437
119STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.27063700
120CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.26396497
121EGR1_19374776_ChIP-ChIP_THP-1_Human1.26383354
122KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.26285226
123GABP_19822575_ChIP-Seq_HepG2_Human1.25747283
124NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.25725548
125PCGF2_27294783_Chip-Seq_ESCs_Mouse1.24413556
126ESR2_21235772_ChIP-Seq_MCF-7_Human1.24385729
127RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.23804774
128EZH2_27294783_Chip-Seq_ESCs_Mouse1.23095334
129PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.21385817
130CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.21297823
131MTF2_20144788_ChIP-Seq_MESCs_Mouse1.21100415
132TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.20511786
133SREBP1_19666523_ChIP-Seq_LIVER_Mouse1.18825401
134ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.18792786
135IGF1R_20145208_ChIP-Seq_DFB_Human1.18765530
136ESR1_20079471_ChIP-ChIP_T-47D_Human1.18265668
137CJUN_26792858_Chip-Seq_BT549_Human1.17779244
138TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.16710511
139CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.16277951
140BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.15707567
141UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.15675165
142SUZ12_27294783_Chip-Seq_NPCs_Mouse1.14479981
143* OCT4_18692474_ChIP-Seq_MEFs_Mouse1.14055933
144* TFEB_21752829_ChIP-Seq_HELA_Human1.13799583
145CNOT3_19339689_ChIP-ChIP_MESCs_Mouse1.12435247
146STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.12379959
147* P300_27058665_Chip-Seq_ZR-75-30cells_Human1.11946131
148SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.11458831
149* ZFP281_18757296_ChIP-ChIP_E14_Mouse1.10807056
150ER_23166858_ChIP-Seq_MCF-7_Human1.10354889
151STAT6_21828071_ChIP-Seq_BEAS2B_Human1.09530303
152* KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.09471172
153SMAD_19615063_ChIP-ChIP_OVARY_Human1.08695547
154VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.08587765
155RNF2_27304074_Chip-Seq_ESCs_Mouse1.07689381
156P300_19829295_ChIP-Seq_ESCs_Human1.07639853
157ZNF217_24962896_ChIP-Seq_MCF-7_Human1.07062941
158YY1_21170310_ChIP-Seq_MESCs_Mouse1.06974476
159RNF2_27304074_Chip-Seq_NSC_Mouse1.06865084
160* CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.06565539
161SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.06414875
162* TTF2_22483619_ChIP-Seq_HELA_Human1.06096417
163* TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.05959796
164E2F4_17652178_ChIP-ChIP_JURKAT_Human1.05746852
165PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.05383912
166MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.04838816
167* KDM5A_27292631_Chip-Seq_BREAST_Human1.04802474
168TRIM28_17542650_ChIP-ChIP_NTERA2_Human1.04448647
169DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.03865863
170E2F1_21310950_ChIP-Seq_MCF-7_Human1.03396223
171NFE2_27457419_Chip-Seq_LIVER_Mouse1.03251539
172* NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.02829562
173KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.02118362
174POU3F2_20337985_ChIP-ChIP_501MEL_Human1.01169757
175* SOX2_18692474_ChIP-Seq_MEFs_Mouse1.01055581
176THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.00782271
177PCGF2_27294783_Chip-Seq_NPCs_Mouse1.00490817
178PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.00389723
179EZH2_27294783_Chip-Seq_NPCs_Mouse1.00200095
180TCFCP2L1_18555785_ChIP-Seq_MESCs_Mouse0.99459619
181CTCF_18555785_ChIP-Seq_MESCs_Mouse0.99387749
182* CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.98026171
183ESR1_21235772_ChIP-Seq_MCF-7_Human0.97600624
184TCF3_18692474_ChIP-Seq_MEFs_Mouse0.97512765
185SREBP2_21459322_ChIP-Seq_LIVER_Mouse0.97498208
186EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse0.96780950
187NANOG_21062744_ChIP-ChIP_HESCs_Human0.96215685
188EOMES_20176728_ChIP-ChIP_TSCs_Mouse0.96176440
189EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse0.95820107
190P300_18555785_Chip-Seq_ESCs_Mouse0.94261058
191EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human0.94018852
192LYL1_20887958_ChIP-Seq_HPC-7_Mouse0.92178464
193FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.88701815
194PPAR_26484153_Chip-Seq_NCI-H1993_Human0.87930415
195NANOG_18555785_Chip-Seq_ESCs_Mouse0.87509876

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003136_yellow_coat_color5.50932464
2MP0003724_increased_susceptibility_to4.45029300
3MP0008438_abnormal_cutaneous_collagen3.61372428
4MP0005409_darkened_coat_color3.48952952
5MP0004381_abnormal_hair_follicle3.43879471
6MP0003705_abnormal_hypodermis_morpholog3.42660602
7MP0009379_abnormal_foot_pigmentation3.37066929
8MP0005058_abnormal_lysosome_morphology3.00510307
9MP0001188_hyperpigmentation2.95451159
10MP0003303_peritoneal_inflammation2.92913077
11MP0003566_abnormal_cell_adhesion2.77585169
12MP0002877_abnormal_melanocyte_morpholog2.75032115
13MP0003693_abnormal_embryo_hatching2.67791686
14MP0010030_abnormal_orbit_morphology2.67733707
15MP0010234_abnormal_vibrissa_follicle2.46546889
16MP0001849_ear_inflammation2.44544309
17MP0004957_abnormal_blastocyst_morpholog2.41532953
18MP0004233_abnormal_muscle_weight2.28390236
19MP0002796_impaired_skin_barrier2.22216301
20MP0003111_abnormal_nucleus_morphology2.22009984
21MP0005451_abnormal_body_composition2.20900400
22MP0008932_abnormal_embryonic_tissue2.17720780
23MP0003279_aneurysm2.13678313
24MP0009840_abnormal_foam_cell2.11240555
25MP0005275_abnormal_skin_tensile2.08835686
26MP0010352_gastrointestinal_tract_polyps2.07094873
27MP0000537_abnormal_urethra_morphology2.05933144
28MP0002102_abnormal_ear_morphology1.96983378
29MP0005501_abnormal_skin_physiology1.95128571
30MP0004858_abnormal_nervous_system1.86620964
31MP0001958_emphysema1.86526375
32MP0003828_pulmonary_edema1.86362652
33MP0002148_abnormal_hypersensitivity_rea1.86164703
34MP0004272_abnormal_basement_membrane1.79978374
35MP0003077_abnormal_cell_cycle1.75082884
36MP0003453_abnormal_keratinocyte_physiol1.74581988
37MP0003436_decreased_susceptibility_to1.73547399
38MP0001879_abnormal_lymphatic_vessel1.72825276
39MP0001730_embryonic_growth_arrest1.70728973
40MP0003806_abnormal_nucleotide_metabolis1.68629125
41MP0005171_absent_coat_pigmentation1.68341235
42MP0005076_abnormal_cell_differentiation1.65619375
43MP0005257_abnormal_intraocular_pressure1.64573239
44MP0002933_joint_inflammation1.62615840
45MP0002249_abnormal_larynx_morphology1.62230180
46MP0005503_abnormal_tendon_morphology1.58317590
47MP0004264_abnormal_extraembryonic_tissu1.57350627
48MP0009672_abnormal_birth_weight1.56563974
49MP0000015_abnormal_ear_pigmentation1.56494818
50MP0004185_abnormal_adipocyte_glucose1.56075216
51MP0001533_abnormal_skeleton_physiology1.54609889
52MP0002998_abnormal_bone_remodeling1.53455995
53MP0010094_abnormal_chromosome_stability1.52677829
54MP0005623_abnormal_meninges_morphology1.52343627
55MP0006292_abnormal_olfactory_placode1.48812759
56MP0008007_abnormal_cellular_replicative1.45425273
57MP0005174_abnormal_tail_pigmentation1.44136731
58MP0005164_abnormal_response_to1.41893247
59MP0009785_altered_susceptibility_to1.39040824
60MP0001835_abnormal_antigen_presentation1.37764739
61MP0009250_abnormal_appendicular_skeleto1.36814417
62MP0005000_abnormal_immune_tolerance1.35993026
63MP0005595_abnormal_vascular_smooth1.35391258
64MP0002419_abnormal_innate_immunity1.33795774
65MP0003011_delayed_dark_adaptation1.33392388
66MP0005023_abnormal_wound_healing1.32905828
67MP0002277_abnormal_respiratory_mucosa1.31983506
68MP0000767_abnormal_smooth_muscle1.31171536
69MP0000350_abnormal_cell_proliferation1.31087226
70MP0002177_abnormal_outer_ear1.29740102
71MP0002080_prenatal_lethality1.25544845
72MP0009053_abnormal_anal_canal1.25092663
73MP0010368_abnormal_lymphatic_system1.24211076
74MP0000678_abnormal_parathyroid_gland1.23894880
75MP0000566_synostosis1.23125723
76MP0001216_abnormal_epidermal_layer1.19182597
77MP0003315_abnormal_perineum_morphology1.18432551
78MP0005390_skeleton_phenotype1.18169901
79MP0000579_abnormal_nail_morphology1.17629294
80MP0000490_abnormal_crypts_of1.16839452
81MP0006082_CNS_inflammation1.16568417
82MP0003186_abnormal_redox_activity1.15604836
83MP0002697_abnormal_eye_size1.15369825
84MP0004782_abnormal_surfactant_physiolog1.14933589
85* MP0005380_embryogenesis_phenotype1.14721004
86* MP0001672_abnormal_embryogenesis/_devel1.14721004
87MP0009764_decreased_sensitivity_to1.11270761
88MP0004510_myositis1.11124752
89MP0000049_abnormal_middle_ear1.10493161
90MP0005025_abnormal_response_to1.09663212
91MP0005165_increased_susceptibility_to1.09051364
92MP0002089_abnormal_postnatal_growth/wei1.07428025
93MP0003195_calcinosis1.07198441
94MP0002085_abnormal_embryonic_tissue1.06989499
95MP0001727_abnormal_embryo_implantation1.06112833
96MP0002254_reproductive_system_inflammat1.05275187
97MP0000358_abnormal_cell_content/1.04968881
98MP0000372_irregular_coat_pigmentation1.04392544
99MP0009384_cardiac_valve_regurgitation1.04224824
100* MP0003984_embryonic_growth_retardation1.03490926
101MP0003448_altered_tumor_morphology1.03190611
102MP0005360_urolithiasis1.02432827
103MP0000343_altered_response_to1.01977627
104MP0002295_abnormal_pulmonary_circulatio1.01454908
105MP0003385_abnormal_body_wall1.01364832
106MP0001697_abnormal_embryo_size1.01148455
107MP0000627_abnormal_mammary_gland1.00751668
108MP0002282_abnormal_trachea_morphology1.00273328
109MP0005084_abnormal_gallbladder_morpholo0.99372937
110MP0000858_altered_metastatic_potential0.99019032
111MP0002086_abnormal_extraembryonic_tissu0.98733099
112* MP0002088_abnormal_embryonic_growth/wei0.97930732
113MP0000467_abnormal_esophagus_morphology0.97813133
114MP0001542_abnormal_bone_strength0.95852417
115MP0001915_intracranial_hemorrhage0.95314811
116MP0009278_abnormal_bone_marrow0.94543097
117MP0001881_abnormal_mammary_gland0.94016093
118MP0000750_abnormal_muscle_regeneration0.92950803
119MP0000377_abnormal_hair_follicle0.92232402
120MP0003938_abnormal_ear_development0.90514324
121MP0001790_abnormal_immune_system0.90077098
122MP0005387_immune_system_phenotype0.90077098
123MP0002452_abnormal_antigen_presenting0.89724473
124MP0000762_abnormal_tongue_morphology0.89587246
125MP0001663_abnormal_digestive_system0.89333826
126MP0010307_abnormal_tumor_latency0.87378752
127MP0001243_abnormal_dermal_layer0.87355981
128MP0005621_abnormal_cell_physiology0.87284999
129MP0002133_abnormal_respiratory_system0.87216247
130MP0005388_respiratory_system_phenotype0.87216247
131MP0000313_abnormal_cell_death0.87125359
132MP0002111_abnormal_tail_morphology0.87076929
133MP0001346_abnormal_lacrimal_gland0.86487083
134MP0003950_abnormal_plasma_membrane0.86435936
135MP0005197_abnormal_uvea_morphology0.85883716
136MP0000249_abnormal_blood_vessel0.84332320
137MP0002084_abnormal_developmental_patter0.84102743
138MP0005248_abnormal_Harderian_gland0.83606649
139MP0000751_myopathy0.83598272
140MP0000003_abnormal_adipose_tissue0.83387770
141MP0005083_abnormal_biliary_tract0.83345905
142MP0010771_integument_phenotype0.83176007
143MP0005408_hypopigmentation0.82089030
144MP0005384_cellular_phenotype0.81601729
145MP0001661_extended_life_span0.81549661
146MP0005508_abnormal_skeleton_morphology0.81278481
147MP0001919_abnormal_reproductive_system0.80928780
148MP0002723_abnormal_immune_serum0.80856948
149MP0002092_abnormal_eye_morphology0.80689414
150MP0003123_paternal_imprinting0.80607768
151MP0003942_abnormal_urinary_system0.79579854
152MP0002876_abnormal_thyroid_physiology0.79358077
153MP0004883_abnormal_blood_vessel0.78672300
154MP0005310_abnormal_salivary_gland0.78567249
155MP0002098_abnormal_vibrissa_morphology0.78278519
156MP0001851_eye_inflammation0.77275759
157MP0005167_abnormal_blood-brain_barrier0.77005144
158MP0003191_abnormal_cellular_cholesterol0.76627819
159MP0003690_abnormal_glial_cell0.75314830
160MP0002405_respiratory_system_inflammati0.73258511
161MP0000681_abnormal_thyroid_gland0.73256891
162MP0002896_abnormal_bone_mineralization0.73252138
163MP0003329_amyloid_beta_deposits0.73109475
164MP0008469_abnormal_protein_level0.72247044
165MP0005381_digestive/alimentary_phenotyp0.72125445
166MP0003091_abnormal_cell_migration0.72076059
167MP0000432_abnormal_head_morphology0.71665508
168MP0005193_abnormal_anterior_eye0.69230438
169MP0000163_abnormal_cartilage_morphology0.69206407
170MP0002060_abnormal_skin_morphology0.69100592
171MP0004197_abnormal_fetal_growth/weight/0.69011620
172MP0005330_cardiomyopathy0.68948244
173MP0001853_heart_inflammation0.68600581
174MP0008260_abnormal_autophagy0.67964700
175MP0002138_abnormal_hepatobiliary_system0.67634809
176MP0000428_abnormal_craniofacial_morphol0.67376778
177MP0005671_abnormal_response_to0.67352793
178MP0003941_abnormal_skin_development0.66844097

Predicted human phenotypes

RankGene SetZ-score
1Joint hemorrhage (HP:0005261)4.91232939
2Prolonged partial thromboplastin time (HP:0003645)4.24023970
3Premature rupture of membranes (HP:0001788)3.75993522
4Pulmonary artery stenosis (HP:0004415)3.41618945
5Hyperacusis (HP:0010780)3.38286516
6Glomerulonephritis (HP:0000099)3.33644918
7Menorrhagia (HP:0000132)3.23978516
8Systemic lupus erythematosus (HP:0002725)3.04867839
9Selective tooth agenesis (HP:0001592)3.03172978
10Trismus (HP:0000211)3.01336776
11Septo-optic dysplasia (HP:0100842)2.99827106
12Aplasia cutis congenita (HP:0001057)2.98167832
13Abnormality of the axillary hair (HP:0100134)2.96638091
14Abnormality of secondary sexual hair (HP:0009888)2.96638091
15Short nail (HP:0001799)2.85686031
16Abnormality of glycolipid metabolism (HP:0010969)2.85371345
17Abnormality of liposaccharide metabolism (HP:0010968)2.85371345
18Abnormality of glycosphingolipid metabolism (HP:0004343)2.85371345
19Obstructive lung disease (HP:0006536)2.83282250
20Chronic obstructive pulmonary disease (HP:0006510)2.83282250
21Distal lower limb muscle weakness (HP:0009053)2.81020496
22Spontaneous hematomas (HP:0007420)2.78614906
23Nephritis (HP:0000123)2.77731746
24Abnormal ciliary motility (HP:0012262)2.74436927
25Hypophosphatemic rickets (HP:0004912)2.74316524
26Abnormality of the distal phalanges of the toes (HP:0010182)2.74204962
27Achilles tendon contracture (HP:0001771)2.71073318
28Prolonged neonatal jaundice (HP:0006579)2.69172095
29Distal lower limb amyotrophy (HP:0008944)2.60015529
30Atrophic scars (HP:0001075)2.59461262
31Submucous cleft hard palate (HP:0000176)2.57196145
32Craniofacial hyperostosis (HP:0004493)2.53102058
33Protrusio acetabuli (HP:0003179)2.51562165
34Abnormality of the Achilles tendon (HP:0005109)2.44838160
35Vertebral compression fractures (HP:0002953)2.43753099
36Patchy hypopigmentation of hair (HP:0011365)2.43614375
37Myocardial infarction (HP:0001658)2.43163613
38Multiple enchondromatosis (HP:0005701)2.39821761
39Rough bone trabeculation (HP:0100670)2.37367412
40Recurrent abscess formation (HP:0002722)2.37234459
41Overriding aorta (HP:0002623)2.36662225
42Cervical subluxation (HP:0003308)2.33984366
43Purpura (HP:0000979)2.32344212
44Complement deficiency (HP:0004431)2.31906714
45Aplasia/Hypoplasia involving the sinuses (HP:0009120)2.31730617
46Syringomyelia (HP:0003396)2.31615867
47Spinal cord lesions (HP:0100561)2.31615867
48Progressive muscle weakness (HP:0003323)2.31149675
49Stomatitis (HP:0010280)2.31117785
50White forelock (HP:0002211)2.30731909
51Eczematoid dermatitis (HP:0000976)2.29247851
52Agammaglobulinemia (HP:0004432)2.28804324
53Ankle contracture (HP:0006466)2.28765796
54Attenuation of retinal blood vessels (HP:0007843)2.27744124
55Distal upper limb amyotrophy (HP:0007149)2.27004797
56Upper limb amyotrophy (HP:0009129)2.27004797
57Ragged-red muscle fibers (HP:0003200)2.25921920
58Ulnar bowing (HP:0003031)2.25813042
59Abnormality of the nasal septum (HP:0000419)2.24314405
60Thick nail (HP:0001805)2.23636469
61Abnormality of the umbilical cord (HP:0010881)2.21488544
62Nasolacrimal duct obstruction (HP:0000579)2.21476177
63Aortic dissection (HP:0002647)2.20478643
64Spastic diplegia (HP:0001264)2.20325327
65Abnormality of complement system (HP:0005339)2.18256773
66Abnormal gallbladder physiology (HP:0012438)2.17190631
67Cholecystitis (HP:0001082)2.17190631
68Fragile skin (HP:0001030)2.15610569
69Abnormal respiratory motile cilium physiology (HP:0012261)2.15481820
70Osteolytic defects of the hand bones (HP:0009699)2.14997950
71Osteolytic defects of the phalanges of the hand (HP:0009771)2.14997950
72Insomnia (HP:0100785)2.14218395
73Right ventricular cardiomyopathy (HP:0011663)2.08228618
74Aplasia/Hypoplasia of the sacrum (HP:0008517)2.07368284
75Microvesicular hepatic steatosis (HP:0001414)2.07283392
76Back pain (HP:0003418)2.06932250
77Conical tooth (HP:0000698)2.06375744
78Parakeratosis (HP:0001036)2.05330623
79Cardiovascular calcification (HP:0011915)2.04307329
80Corneal dystrophy (HP:0001131)2.04142554
81Sex reversal (HP:0012245)2.03733104
82Abnormal sex determination (HP:0012244)2.03733104
83Hypokinesia (HP:0002375)2.03428177
84Soft skin (HP:0000977)2.02207684
85Absent/shortened dynein arms (HP:0200106)2.01122156
86Dynein arm defect of respiratory motile cilia (HP:0012255)2.01122156
87Asymmetry of the thorax (HP:0001555)1.99600082
88Increased connective tissue (HP:0009025)1.99361338
89Renal duplication (HP:0000075)1.98367866
90Abnormality of the pulmonary veins (HP:0011718)1.98009177
91Congenital nonbullous ichthyosiform erythroderma (HP:0007479)1.97602309
92Cranial hyperostosis (HP:0004437)1.97079795
93Centrally nucleated skeletal muscle fibers (HP:0003687)1.96857908
94Respiratory insufficiency due to defective ciliary clearance (HP:0200073)1.96836698
95Delayed cranial suture closure (HP:0000270)1.96332419
96Recurrent gram-negative bacterial infections (HP:0005420)1.95930421
97Deviation of the thumb (HP:0009603)1.93485417
98Biconcave vertebral bodies (HP:0004586)1.92865650
99Epistaxis (HP:0000421)1.92636436
100Thyroid-stimulating hormone excess (HP:0002925)1.91848269
101Meningitis (HP:0001287)1.91143793
102Vacuolated lymphocytes (HP:0001922)1.90639128
103Hypoplasia of the capital femoral epiphysis (HP:0003090)1.90536361
104Hand muscle atrophy (HP:0009130)1.90293618
105Increased cerebral lipofuscin (HP:0011813)1.89856384
106Abnormal trabecular bone morphology (HP:0100671)1.89321203
107Overfolded helix (HP:0000396)1.88379313
108Nonimmune hydrops fetalis (HP:0001790)1.88322039
109Generalized amyotrophy (HP:0003700)1.87546671
110Shallow orbits (HP:0000586)1.87394872
111Optic nerve hypoplasia (HP:0000609)1.87287320
112Hypoplasia of the iris (HP:0007676)1.86657589
113Peritonitis (HP:0002586)1.85904201
114J-shaped sella turcica (HP:0002680)1.85099055
115Vascular calcification (HP:0004934)1.84660887
116Humeroradial synostosis (HP:0003041)1.83537690
117Synostosis involving the elbow (HP:0003938)1.83537690
118Partial duplication of the phalanx of hand (HP:0009999)1.82089094
119Elbow flexion contracture (HP:0002987)1.80988424
120Morphological abnormality of the middle ear (HP:0008609)1.80818266
121Fasciculations (HP:0002380)1.79305116
122Elfin facies (HP:0004428)1.79092725
123Abnormality of dentin (HP:0010299)1.78934709
124Proximal placement of thumb (HP:0009623)1.78866997
125Loss of speech (HP:0002371)1.78490422
126Lower limb amyotrophy (HP:0007210)1.78424853
127Absent septum pellucidum (HP:0001331)1.77511397
128Blue sclerae (HP:0000592)1.77122536
129Advanced eruption of teeth (HP:0006288)1.76750238
130Natal tooth (HP:0000695)1.76731334
131Long palpebral fissure (HP:0000637)1.76305041
132Entropion (HP:0000621)1.75294971
133Type I transferrin isoform profile (HP:0003642)1.75188310
134Abnormality of the lacrimal duct (HP:0011481)1.74472635
135Cellulitis (HP:0100658)1.74117686
136Femoral bowing (HP:0002980)1.73856526
137Absent frontal sinuses (HP:0002688)1.73814371
138Bone pain (HP:0002653)1.73618543
139Porencephaly (HP:0002132)1.73194265
140Interstitial pulmonary disease (HP:0006530)1.73075701
141Axonal loss (HP:0003447)1.72798542
142Abnormality of the septum pellucidum (HP:0007375)1.72457011
143Venous insufficiency (HP:0005293)1.71822629
144Stage 5 chronic kidney disease (HP:0003774)1.71613890
145Follicular hyperkeratosis (HP:0007502)1.71531372
146Broad distal phalanx of finger (HP:0009836)1.70734256
147Spinal rigidity (HP:0003306)1.70660153
148Nuclear cataract (HP:0100018)1.69993350
149Abnormality of glycolysis (HP:0004366)1.69744599
150Micronodular cirrhosis (HP:0001413)1.69604340
151Spinal cord compression (HP:0002176)1.69512992
152Sparse eyelashes (HP:0000653)1.69311019
153Abnormality of primary teeth (HP:0006481)1.69136303
154Neonatal short-limb short stature (HP:0008921)1.68889022
155Pterygium (HP:0001059)1.68008294
156Prolonged bleeding time (HP:0003010)1.67979364
157Partial duplication of thumb phalanx (HP:0009944)1.66738536
158Obstructive sleep apnea (HP:0002870)1.66699280
159Short tibia (HP:0005736)1.66119936
160Mediastinal lymphadenopathy (HP:0100721)1.66058137
161Hepatosplenomegaly (HP:0001433)1.65659319
162Abnormalities of placenta or umbilical cord (HP:0001194)1.65605760
163Abnormality of the nasolacrimal system (HP:0000614)1.64769029
164Arnold-Chiari malformation (HP:0002308)1.64511166
165Mitral stenosis (HP:0001718)1.63430143
166Flat acetabular roof (HP:0003180)1.62850044
167Basal ganglia calcification (HP:0002135)1.62733464
168Spondylolisthesis (HP:0003302)1.62314325
169Recurrent bacterial skin infections (HP:0005406)1.61714350
170Breech presentation (HP:0001623)1.59367690
171Patellar dislocation (HP:0002999)1.59168203
172Upper motor neuron abnormality (HP:0002127)1.58740228
173Testicular atrophy (HP:0000029)1.57831305
174Reduced antithrombin III activity (HP:0001976)1.57281165
175Bladder diverticulum (HP:0000015)1.55275246
176Abnormality of carpal bone ossification (HP:0006257)1.55131411
177Upper limb muscle weakness (HP:0003484)1.54987223
178Abnormality of the acetabulum (HP:0003170)1.54837836
179Dysostosis multiplex (HP:0000943)1.53448349
180Increased neuronal autofluorescent lipopigment (HP:0002074)1.52682107
181Facial cleft (HP:0002006)1.52250474
182Disproportionate tall stature (HP:0001519)1.51737332
183Cardiomegaly (HP:0001640)1.51230581
184Abnormality of the fetal cardiovascular system (HP:0010948)1.50834975
185Abnormal umbilical cord blood vessels (HP:0011403)1.50834975
186Single umbilical artery (HP:0001195)1.50834975

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MKNK26.33984334
2BLK6.05103754
3CASK4.30410069
4MKNK13.68185223
5SMG13.23750338
6TRIB33.00770650
7PAK42.68079144
8TESK12.65046229
9TLK12.46783771
10BUB12.40248017
11MAP3K142.39062946
12VRK22.31888944
13TESK22.27366875
14FES2.22918833
15IRAK32.06858789
16ERN12.01961785
17FER1.79517800
18IRAK11.79434276
19ICK1.73377496
20LATS21.72555055
21IRAK41.68620153
22SRPK11.66571473
23MET1.60992200
24NME21.60752552
25LIMK11.58013008
26PBK1.57721138
27PDGFRA1.56732611
28TTK1.55074156
29PTK21.54495161
30PIM21.53368385
31MUSK1.53235201
32CSK1.50100678
33FGFR41.49596103
34PKN21.45716542
35NLK1.43978465
36EEF2K1.43276913
37TGFBR21.42796424
38IKBKE1.37165303
39CDK121.35539915
40TTN1.34266602
41NTRK11.32464740
42CDC71.31896270
43YES11.29281357
44SCYL21.26527982
45PRPF4B1.26376997
46PKN11.25621049
47RPS6KB21.21997279
48RIPK11.20774219
49CDK71.16867258
50NME11.14586090
51FGR1.13340915
52TAOK21.11913657
53EPHA31.07795094
54NEK11.07561401
55TBK11.07275715
56MST41.05126388
57GRK71.04819523
58NUAK11.02540854
59EPHB21.00605360
60TSSK61.00508596
61KDR0.99989607
62BMPR20.99110631
63BCKDK0.98341289
64MAP3K80.98072756
65LMTK20.96853588
66NEK90.96696746
67INSRR0.96242537
68IRAK20.95117319
69PAK20.94712003
70MAP2K20.94451565
71CDK80.94057376
72PRKD20.92081990
73EIF2AK10.92021330
74PHKG10.91731759
75PHKG20.91731759
76MST1R0.90706150
77PTK60.90617399
78FLT30.89824846
79EIF2AK20.87232730
80TYK20.86000234
81AURKA0.85538518
82EPHB10.84581389
83ARAF0.83151355
84TNIK0.82422967
85MAPK150.80936910
86LRRK20.79839888
87CLK10.79644452
88TXK0.79620881
89IKBKB0.79055602
90MTOR0.78478086
91PIK3CG0.77362617
92MAP3K30.73554721
93RIPK40.72457052
94DMPK0.72324589
95AURKB0.71594015
96TAF10.70581726
97ILK0.67622762
98MAPKAPK30.66028836
99PRKAA20.65513016
100DAPK10.65113659
101BRSK10.63808219
102PIK3CA0.63351538
103TIE10.62940517
104LYN0.62169383
105CHEK20.62120858
106PIM10.61959994
107ADRBK20.61268549
108GRK10.60935576
109PRKG20.60924154
110MAP3K130.59700163
111HCK0.59563693
112TRPM70.57017771
113KIT0.56461448
114DDR20.56361171
115PLK10.56069050
116CDK90.55504016
117STK390.55415316
118PAK10.54489784
119BMX0.54255573
120BMPR1B0.53654728
121MAP3K110.53344414
122LCK0.52559031
123JAK10.52380004
124TAOK30.51358661
125RPS6KA50.51183410
126AKT20.51143089
127ABL20.50948232
128MAP3K100.50555328
129TEC0.50544881
130PRKCQ0.49947326
131RPS6KA40.49220866
132CDK40.48838245
133ALK0.48395312
134DYRK1A0.47804992
135ROCK20.47345145
136PDK20.46435234
137STK100.45883871
138MOS0.45377029
139CDK60.45102437
140PRKCI0.44921849
141PRKCE0.43812976
142CHEK10.43701232
143LATS10.42916750
144NEK60.42116128
145JAK30.41835553
146GSK3A0.41071942
147STK160.40854878
148TNK20.39853143
149DAPK30.39551598
150MYLK0.38918924
151SIK10.38153410
152PRKD10.38113054
153ERBB40.37615968
154CAMK2G0.36588480
155WEE10.35671357
156CAMK2B0.35398911
157HIPK20.35270953
158ABL10.34842518
159PRKG10.34714182
160STK40.34694203
161SIK30.33564624
162ATR0.33367653
163BRAF0.33273101
164EPHA20.32973497
165CDK150.31777336
166RPS6KA20.31698361
167CSNK1G30.31419714
168CDK11A0.30753370
169INSR0.29295678
170MARK30.27334257
171FYN0.26239640

Predicted pathways (KEGG)

RankGene SetZ-score
1Staphylococcus aureus infection_Homo sapiens_hsa051503.63816710
2DNA replication_Homo sapiens_hsa030303.29996654
3Proteasome_Homo sapiens_hsa030502.72101252
4Malaria_Homo sapiens_hsa051442.72041709
5Citrate cycle (TCA cycle)_Homo sapiens_hsa000202.67319977
6Biosynthesis of amino acids_Homo sapiens_hsa012302.65269859
7Complement and coagulation cascades_Homo sapiens_hsa046102.64473464
8Pentose phosphate pathway_Homo sapiens_hsa000302.35390497
9Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009702.34525737
10Base excision repair_Homo sapiens_hsa034102.28925364
11Galactose metabolism_Homo sapiens_hsa000522.28839432
122-Oxocarboxylic acid metabolism_Homo sapiens_hsa012102.25037727
13Other glycan degradation_Homo sapiens_hsa005112.21757992
14Mismatch repair_Homo sapiens_hsa034302.19381404
15Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006032.12209772
16Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005332.05306638
17Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005122.01719193
18Carbon metabolism_Homo sapiens_hsa012001.88928368
19Fructose and mannose metabolism_Homo sapiens_hsa000511.87094463
20Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.82483499
21Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.82102085
22NF-kappa B signaling pathway_Homo sapiens_hsa040641.81601293
23Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.80937365
24N-Glycan biosynthesis_Homo sapiens_hsa005101.71591695
25Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.70137962
26Pentose and glucuronate interconversions_Homo sapiens_hsa000401.67263726
27Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.66293703
28Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.63697501
29Central carbon metabolism in cancer_Homo sapiens_hsa052301.60706372
30ECM-receptor interaction_Homo sapiens_hsa045121.57859974
31Bladder cancer_Homo sapiens_hsa052191.53901494
32Spliceosome_Homo sapiens_hsa030401.50453569
33Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.47225502
34Leishmaniasis_Homo sapiens_hsa051401.44069751
35Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.43655332
36Thyroid cancer_Homo sapiens_hsa052161.43052634
37Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.41327013
38Rheumatoid arthritis_Homo sapiens_hsa053231.40517890
39Pyrimidine metabolism_Homo sapiens_hsa002401.39764225
40African trypanosomiasis_Homo sapiens_hsa051431.37540310
41Cell adhesion molecules (CAMs)_Homo sapiens_hsa045141.37335564
42Sphingolipid metabolism_Homo sapiens_hsa006001.37137897
43Cyanoamino acid metabolism_Homo sapiens_hsa004601.35514424
44Pertussis_Homo sapiens_hsa051331.34853624
45Graft-versus-host disease_Homo sapiens_hsa053321.33496700
46Arachidonic acid metabolism_Homo sapiens_hsa005901.33085348
47Toll-like receptor signaling pathway_Homo sapiens_hsa046201.33058138
48Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.31843874
49Osteoclast differentiation_Homo sapiens_hsa043801.31450532
50Measles_Homo sapiens_hsa051621.31375989
51Phototransduction_Homo sapiens_hsa047441.29785933
52Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.28913916
53Vibrio cholerae infection_Homo sapiens_hsa051101.28028614
54Hematopoietic cell lineage_Homo sapiens_hsa046401.26448169
55Glutathione metabolism_Homo sapiens_hsa004801.22551869
56Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.21953540
57Cell cycle_Homo sapiens_hsa041101.21273289
58Vitamin B6 metabolism_Homo sapiens_hsa007501.21152116
59Steroid hormone biosynthesis_Homo sapiens_hsa001401.20400341
60Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.20213090
61Retinol metabolism_Homo sapiens_hsa008301.18219487
62Nucleotide excision repair_Homo sapiens_hsa034201.17960091
63Pyruvate metabolism_Homo sapiens_hsa006201.16806502
64Cysteine and methionine metabolism_Homo sapiens_hsa002701.16294456
65Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.16266533
66AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.14567345
67RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.14163807
68Intestinal immune network for IgA production_Homo sapiens_hsa046721.13943756
69RNA transport_Homo sapiens_hsa030131.08169720
70Prion diseases_Homo sapiens_hsa050201.06400508
71Fatty acid elongation_Homo sapiens_hsa000621.05776622
72Autoimmune thyroid disease_Homo sapiens_hsa053201.04712020
73Glycosaminoglycan degradation_Homo sapiens_hsa005311.03529737
74Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.02962933
75Allograft rejection_Homo sapiens_hsa053301.02255541
76Melanoma_Homo sapiens_hsa052181.02105980
77Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.01275729
78Steroid biosynthesis_Homo sapiens_hsa001001.00599591
79Phagosome_Homo sapiens_hsa041450.99706775
80Jak-STAT signaling pathway_Homo sapiens_hsa046300.98202587
81Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.97937169
82Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.97698824
83Tuberculosis_Homo sapiens_hsa051520.96285953
84Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.96021739
85Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.95142198
86Leukocyte transendothelial migration_Homo sapiens_hsa046700.94526653
87Asthma_Homo sapiens_hsa053100.93765008
88Salmonella infection_Homo sapiens_hsa051320.93705112
89Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.93421306
90One carbon pool by folate_Homo sapiens_hsa006700.92451389
91Focal adhesion_Homo sapiens_hsa045100.90628238
92Histidine metabolism_Homo sapiens_hsa003400.90578485
93Phenylalanine metabolism_Homo sapiens_hsa003600.89659131
94Adherens junction_Homo sapiens_hsa045200.89391876
95Notch signaling pathway_Homo sapiens_hsa043300.85450042
96Chronic myeloid leukemia_Homo sapiens_hsa052200.84830679
97Lysosome_Homo sapiens_hsa041420.84777155
98Amoebiasis_Homo sapiens_hsa051460.84665567
99Regulation of actin cytoskeleton_Homo sapiens_hsa048100.84123656
100NOD-like receptor signaling pathway_Homo sapiens_hsa046210.82968397
101Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.82511650
102Protein export_Homo sapiens_hsa030600.82017476
103Axon guidance_Homo sapiens_hsa043600.81931482
104Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.81630396
105Ether lipid metabolism_Homo sapiens_hsa005650.81416216
106Sulfur metabolism_Homo sapiens_hsa009200.81055520
107Shigellosis_Homo sapiens_hsa051310.77935325
108Arginine biosynthesis_Homo sapiens_hsa002200.77390431
109TNF signaling pathway_Homo sapiens_hsa046680.77095544
110Primary immunodeficiency_Homo sapiens_hsa053400.76725822
111Chemical carcinogenesis_Homo sapiens_hsa052040.75863713
112Caffeine metabolism_Homo sapiens_hsa002320.67220234
113Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.66970690
114Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.66940588
115Chemokine signaling pathway_Homo sapiens_hsa040620.66775626
116Pancreatic cancer_Homo sapiens_hsa052120.66656508
117RNA polymerase_Homo sapiens_hsa030200.66319450
118Transcriptional misregulation in cancer_Homo sapiens_hsa052020.66188234
119B cell receptor signaling pathway_Homo sapiens_hsa046620.64107197
120PPAR signaling pathway_Homo sapiens_hsa033200.63844201
121Prostate cancer_Homo sapiens_hsa052150.63621377
122Mineral absorption_Homo sapiens_hsa049780.62946641
123Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.62869323
124Ribosome_Homo sapiens_hsa030100.61651527
125Selenocompound metabolism_Homo sapiens_hsa004500.61428910
126Toxoplasmosis_Homo sapiens_hsa051450.61170397
127Vitamin digestion and absorption_Homo sapiens_hsa049770.60906025
128Homologous recombination_Homo sapiens_hsa034400.60724035
129Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.60375947
130p53 signaling pathway_Homo sapiens_hsa041150.59529905
131mRNA surveillance pathway_Homo sapiens_hsa030150.58813281
132PI3K-Akt signaling pathway_Homo sapiens_hsa041510.58741385
133Protein digestion and absorption_Homo sapiens_hsa049740.58538271
134Platelet activation_Homo sapiens_hsa046110.57872292
135Arginine and proline metabolism_Homo sapiens_hsa003300.57725736
136Apoptosis_Homo sapiens_hsa042100.57694532
137Hippo signaling pathway_Homo sapiens_hsa043900.56820393
138Drug metabolism - other enzymes_Homo sapiens_hsa009830.56198291
139Ras signaling pathway_Homo sapiens_hsa040140.54651008
140Acute myeloid leukemia_Homo sapiens_hsa052210.54073612
141Non-homologous end-joining_Homo sapiens_hsa034500.53981165
142Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.53536494
143Hepatitis C_Homo sapiens_hsa051600.53483410
144MicroRNAs in cancer_Homo sapiens_hsa052060.52253488
145Primary bile acid biosynthesis_Homo sapiens_hsa001200.52016826
146beta-Alanine metabolism_Homo sapiens_hsa004100.51487237
147Basal cell carcinoma_Homo sapiens_hsa052170.50116315
148Tight junction_Homo sapiens_hsa045300.48987551
149Viral carcinogenesis_Homo sapiens_hsa052030.47931276
150Melanogenesis_Homo sapiens_hsa049160.47735590
151Influenza A_Homo sapiens_hsa051640.46101624
152Herpes simplex infection_Homo sapiens_hsa051680.45084850
153Dilated cardiomyopathy_Homo sapiens_hsa054140.44915420
154Proteoglycans in cancer_Homo sapiens_hsa052050.44384229
155Tyrosine metabolism_Homo sapiens_hsa003500.44365446
156Fatty acid metabolism_Homo sapiens_hsa012120.43741900
157Endometrial cancer_Homo sapiens_hsa052130.43303649
158Small cell lung cancer_Homo sapiens_hsa052220.42788055
159Peroxisome_Homo sapiens_hsa041460.41564551
160Epstein-Barr virus infection_Homo sapiens_hsa051690.41370156
161Insulin signaling pathway_Homo sapiens_hsa049100.40591952
162Sulfur relay system_Homo sapiens_hsa041220.39226371
163Starch and sucrose metabolism_Homo sapiens_hsa005000.39173341
164HTLV-I infection_Homo sapiens_hsa051660.39147832
165Pathways in cancer_Homo sapiens_hsa052000.39113070
166Folate biosynthesis_Homo sapiens_hsa007900.38525192
167Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.38457132
168Metabolic pathways_Homo sapiens_hsa011000.37476823
169HIF-1 signaling pathway_Homo sapiens_hsa040660.36107467
170Lysine degradation_Homo sapiens_hsa003100.35626313
171Purine metabolism_Homo sapiens_hsa002300.34881611
172Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.34041531
173Non-small cell lung cancer_Homo sapiens_hsa052230.29043732
174Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.28319024

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