SLC39A10

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: Zinc is an essential cofactor for hundreds of enzymes. It is involved in protein, nucleic acid, carbohydrate, and lipid metabolism, as well as in the control of gene transcription, growth, development, and differentiation. SLC39A10 belongs to a subfamily of proteins that show structural characteristics of zinc transporters (Taylor and Nicholson, 2003 [PubMed 12659941]). NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1synaptic vesicle docking involved in exocytosis (GO:0016081)5.48616179
2regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act5.19226713
3glutamate secretion (GO:0014047)4.93683277
4positive regulation of excitatory postsynaptic membrane potential (GO:2000463)4.88496731
5synaptic vesicle exocytosis (GO:0016079)4.84802744
6regulation of short-term neuronal synaptic plasticity (GO:0048172)4.82183438
7vocalization behavior (GO:0071625)4.66734574
8protein localization to synapse (GO:0035418)4.63118327
9layer formation in cerebral cortex (GO:0021819)4.57067317
10positive regulation of calcium ion-dependent exocytosis (GO:0045956)4.52596616
11chromatin remodeling at centromere (GO:0031055)4.51178050
12DNA double-strand break processing (GO:0000729)4.47897173
13regulation of glutamate receptor signaling pathway (GO:1900449)4.43134118
14synaptic vesicle maturation (GO:0016188)4.42352763
15locomotory exploration behavior (GO:0035641)4.33863891
16CENP-A containing nucleosome assembly (GO:0034080)4.32237839
17regulation of synaptic vesicle exocytosis (GO:2000300)4.26687700
18neuron cell-cell adhesion (GO:0007158)4.26361603
19establishment of integrated proviral latency (GO:0075713)4.13713530
20histone exchange (GO:0043486)4.09203429
21negative regulation of DNA-dependent DNA replication (GO:2000104)4.02951418
22regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)4.00540417
23presynaptic membrane assembly (GO:0097105)3.98529766
24regulation of dendritic spine morphogenesis (GO:0061001)3.97523174
25protein localization to kinetochore (GO:0034501)3.88372321
26synaptic transmission, glutamatergic (GO:0035249)3.80228861
27regulation of long-term neuronal synaptic plasticity (GO:0048169)3.79299220
28mitotic metaphase plate congression (GO:0007080)3.75264191
29nuclear pore complex assembly (GO:0051292)3.73425735
30postsynaptic membrane organization (GO:0001941)3.73159417
31positive regulation of dendritic spine morphogenesis (GO:0061003)3.70806926
32regulation of synaptic vesicle transport (GO:1902803)3.66861984
33ionotropic glutamate receptor signaling pathway (GO:0035235)3.66241629
34neuronal action potential propagation (GO:0019227)3.64460704
35nuclear pore organization (GO:0006999)3.62969346
36DNA replication-independent nucleosome organization (GO:0034724)3.62433643
37DNA replication-independent nucleosome assembly (GO:0006336)3.62433643
38neurotransmitter-gated ion channel clustering (GO:0072578)3.61478132
39neuron-neuron synaptic transmission (GO:0007270)3.59013393
40regulation of neuronal synaptic plasticity (GO:0048168)3.58727495
41presynaptic membrane organization (GO:0097090)3.58342128
42negative regulation of DNA recombination (GO:0045910)3.57491029
43regulation of helicase activity (GO:0051095)3.55325304
44positive regulation of neurotransmitter secretion (GO:0001956)3.55249010
45regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)3.53815085
46regulation of mitotic spindle checkpoint (GO:1903504)3.53815085
47synaptic vesicle endocytosis (GO:0048488)3.53561385
48glutamate receptor signaling pathway (GO:0007215)3.53187632
49dendritic spine morphogenesis (GO:0060997)3.51530700
50metaphase plate congression (GO:0051310)3.49424849
51spindle checkpoint (GO:0031577)3.48532702
52regulation of excitatory postsynaptic membrane potential (GO:0060079)3.44596735
53pre-miRNA processing (GO:0031054)3.44228738
54exploration behavior (GO:0035640)3.43856156
55non-recombinational repair (GO:0000726)3.42192537
56double-strand break repair via nonhomologous end joining (GO:0006303)3.42192537
57DNA replication-dependent nucleosome assembly (GO:0006335)3.41189106
58DNA replication-dependent nucleosome organization (GO:0034723)3.41189106
59mitotic sister chromatid cohesion (GO:0007064)3.41064738
60mitotic spindle checkpoint (GO:0071174)3.39707380
61negative regulation of mitotic metaphase/anaphase transition (GO:0045841)3.37101540
62negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)3.37101540
63negative regulation of mitotic sister chromatid segregation (GO:0033048)3.37101540
64negative regulation of mitotic sister chromatid separation (GO:2000816)3.37101540
65negative regulation of sister chromatid segregation (GO:0033046)3.37101540
66axonal fasciculation (GO:0007413)3.35695512
67long-term synaptic potentiation (GO:0060291)3.35236016
68positive regulation of synapse maturation (GO:0090129)3.33137383
69response to X-ray (GO:0010165)3.32972322
70DNA replication checkpoint (GO:0000076)3.32859090
71somatic hypermutation of immunoglobulin genes (GO:0016446)3.32706786
72somatic diversification of immune receptors via somatic mutation (GO:0002566)3.32706786
73neurotransmitter secretion (GO:0007269)3.31387931
74regulation of postsynaptic membrane potential (GO:0060078)3.30617072
75negative regulation of chromosome segregation (GO:0051985)3.30044535
76regulation of dendritic spine development (GO:0060998)3.28563189
77replication fork processing (GO:0031297)3.28430781
78neuron recognition (GO:0008038)3.27220609
79positive regulation of membrane potential (GO:0045838)3.24940315
80regulation of inhibitory postsynaptic membrane potential (GO:0060080)3.23335379
81regulation of metaphase/anaphase transition of cell cycle (GO:1902099)3.23263947
82regulation of mitotic metaphase/anaphase transition (GO:0030071)3.23263947
83regulation of synaptic plasticity (GO:0048167)3.21110197
84regulation of mitotic sister chromatid separation (GO:0010965)3.18426755
85regulation of mitotic sister chromatid segregation (GO:0033047)3.18426755
86regulation of sister chromatid segregation (GO:0033045)3.18426755
87DNA ligation (GO:0006266)3.17689434
88regulation of neurotransmitter secretion (GO:0046928)3.16203469
89auditory behavior (GO:0031223)3.12982382
90telomere maintenance via telomerase (GO:0007004)3.11423659
91proline transport (GO:0015824)3.10183166
92regulation of nuclear cell cycle DNA replication (GO:0033262)3.09588906
93regulation of attachment of spindle microtubules to kinetochore (GO:0051988)3.07478876
94negative regulation of translation involved in gene silencing by miRNA (GO:0035278)3.06463584
95negative regulation of translation, ncRNA-mediated (GO:0040033)3.06463584
96regulation of translation, ncRNA-mediated (GO:0045974)3.06463584
97regulation of DNA endoreduplication (GO:0032875)3.05487788
98regulation of chromosome segregation (GO:0051983)3.04551370
99mitotic spindle assembly checkpoint (GO:0007094)3.04273196
100gamma-aminobutyric acid signaling pathway (GO:0007214)3.01088211
101kinetochore organization (GO:0051383)3.00246095
102positive regulation of neurotransmitter transport (GO:0051590)2.99848197
103spindle assembly checkpoint (GO:0071173)2.99589878
104IMP biosynthetic process (GO:0006188)2.99344470
105synapsis (GO:0007129)2.97251190
106G-protein coupled glutamate receptor signaling pathway (GO:0007216)2.96402161
107DNA strand elongation involved in DNA replication (GO:0006271)2.95752846
108regulation of synaptic transmission, glutamatergic (GO:0051966)2.94122109
109cerebellar Purkinje cell differentiation (GO:0021702)2.93236553
110protein localization to chromosome, centromeric region (GO:0071459)2.90749806
111ATP-dependent chromatin remodeling (GO:0043044)2.90448064
112long-term memory (GO:0007616)2.90010977
113establishment of chromosome localization (GO:0051303)2.88857505
114mechanosensory behavior (GO:0007638)2.88129424
115response to histamine (GO:0034776)2.87503292
116maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)2.86069217
117L-serine metabolic process (GO:0006563)2.85761516
118establishment of viral latency (GO:0019043)2.85606959
119mitotic G2/M transition checkpoint (GO:0044818)2.85177623
120regulation of centriole replication (GO:0046599)2.83072521
121cochlea development (GO:0090102)2.82867106
122dendritic spine organization (GO:0097061)2.82657420
123heterochromatin organization (GO:0070828)2.82466630
124regulation of posttranscriptional gene silencing (GO:0060147)2.81865202
125regulation of gene silencing by miRNA (GO:0060964)2.81865202
126regulation of gene silencing by RNA (GO:0060966)2.81865202
127negative regulation of dendrite morphogenesis (GO:0050774)2.81839549
128regulation of synapse structural plasticity (GO:0051823)2.80624333
129sister chromatid segregation (GO:0000819)2.80060970
130G-protein coupled acetylcholine receptor signaling pathway (GO:0007213)2.78234706
131regulation of neurotransmitter transport (GO:0051588)2.77236236
132DNA strand elongation (GO:0022616)2.77060027
133purine nucleobase biosynthetic process (GO:0009113)2.76871835
134regulation of respiratory gaseous exchange by neurological system process (GO:0002087)2.76205383
135negative regulation of mitosis (GO:0045839)2.76080919
136innervation (GO:0060384)2.74041423
137behavioral defense response (GO:0002209)2.74011998
138behavioral fear response (GO:0001662)2.74011998
139cerebellar granule cell differentiation (GO:0021707)2.73895585
140positive regulation of dendritic spine development (GO:0060999)2.73172621
141postreplication repair (GO:0006301)2.72968772
142DNA damage response, detection of DNA damage (GO:0042769)2.72732528
143regulation of meiosis I (GO:0060631)2.72451750
144ribosome assembly (GO:0042255)2.71804723
145positive regulation of synaptic transmission, glutamatergic (GO:0051968)2.70121886
146RNA-dependent DNA replication (GO:0006278)2.70083646
147anterior/posterior axis specification, embryo (GO:0008595)2.70059384
148membrane depolarization during cardiac muscle cell action potential (GO:0086012)2.69148585
149pore complex assembly (GO:0046931)2.68386330
150intra-S DNA damage checkpoint (GO:0031573)2.68256489
151learning (GO:0007612)2.67796746
152somatic diversification of immunoglobulins involved in immune response (GO:0002208)2.67706927
153isotype switching (GO:0045190)2.67706927
154somatic recombination of immunoglobulin genes involved in immune response (GO:0002204)2.67706927
155regulation of synapse maturation (GO:0090128)2.66154454
156DNA catabolic process, exonucleolytic (GO:0000738)2.64853110
157positive regulation of synapse assembly (GO:0051965)2.64165748
158mitotic sister chromatid segregation (GO:0000070)2.64016458
159IMP metabolic process (GO:0046040)2.63297238
160positive regulation of chromosome segregation (GO:0051984)2.63247506
161DNA unwinding involved in DNA replication (GO:0006268)2.62304223
162kinetochore assembly (GO:0051382)2.61819889
163behavioral response to cocaine (GO:0048148)2.61771978
164membrane depolarization (GO:0051899)2.61618848
165positive regulation of cardiac muscle cell differentiation (GO:2000727)2.61123297
166negative regulation of hormone biosynthetic process (GO:0032353)2.60821171
167negative regulation of hormone metabolic process (GO:0032351)2.60821171
168regulation of dendrite morphogenesis (GO:0048814)2.60770740
169attachment of spindle microtubules to kinetochore (GO:0008608)2.60423558
170cellular potassium ion homeostasis (GO:0030007)2.60172719
171dorsal/ventral axis specification (GO:0009950)2.58836148
172positive regulation of synaptic transmission (GO:0050806)2.58150383
173neurotransmitter transport (GO:0006836)2.57994208
174somatic recombination of immunoglobulin gene segments (GO:0016447)2.57588560
175mitotic recombination (GO:0006312)2.57532955
176fear response (GO:0042596)2.56811972
177establishment of nucleus localization (GO:0040023)2.56758357
178negative regulation of dendrite development (GO:2000171)2.56238423
179telomere maintenance via semi-conservative replication (GO:0032201)2.55782168
180response to auditory stimulus (GO:0010996)2.54576340
181cell fate commitment involved in formation of primary germ layer (GO:0060795)2.54545213
182negative regulation of nuclear division (GO:0051784)2.53608251
183female gonad development (GO:0008585)2.52796724
184regulation of centrosome cycle (GO:0046605)2.51942492
185central nervous system projection neuron axonogenesis (GO:0021952)2.51918791
186regulation of synaptic transmission (GO:0050804)2.51472454
187negative regulation of synaptic transmission, GABAergic (GO:0032229)2.51446816
188regulation of respiratory system process (GO:0044065)2.50536267
189activation of protein kinase A activity (GO:0034199)2.49734444
190dendrite morphogenesis (GO:0048813)2.49611328
191dendrite development (GO:0016358)2.49366205
192transmission of nerve impulse (GO:0019226)2.47191803
193regulation of synapse organization (GO:0050807)2.46661482
194neuromuscular process controlling balance (GO:0050885)2.45438333
195synapse assembly (GO:0007416)2.45374656
196vesicle transport along microtubule (GO:0047496)2.44911451
197regulation of synapse assembly (GO:0051963)2.44808567

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human5.52178809
2EZH2_22144423_ChIP-Seq_EOC_Human4.98778242
3GBX2_23144817_ChIP-Seq_PC3_Human3.78974444
4E2F4_17652178_ChIP-ChIP_JURKAT_Human3.38155029
5FOXM1_23109430_ChIP-Seq_U2OS_Human2.74151120
6JARID2_20064375_ChIP-Seq_MESCs_Mouse2.73115018
7SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.67823133
8ZFP322A_24550733_ChIP-Seq_MESCs_Mouse2.54660258
9SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.53177711
10MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.49716668
11EZH2_18974828_ChIP-Seq_MESCs_Mouse2.43517796
12RNF2_18974828_ChIP-Seq_MESCs_Mouse2.43517796
13KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.38612056
14EZH2_27304074_Chip-Seq_ESCs_Mouse2.36076704
15SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.30021939
16EED_16625203_ChIP-ChIP_MESCs_Mouse2.29438882
17SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.27674618
18TAF15_26573619_Chip-Seq_HEK293_Human2.21091241
19HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.17204960
20JARID2_20075857_ChIP-Seq_MESCs_Mouse2.13024591
21SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.07724242
22NR4A2_19515692_ChIP-ChIP_MN9D_Mouse2.07451996
23FUS_26573619_Chip-Seq_HEK293_Human2.05251543
24CTBP2_25329375_ChIP-Seq_LNCAP_Human2.03575028
25SALL1_21062744_ChIP-ChIP_HESCs_Human2.03431956
26SMARCD1_25818293_ChIP-Seq_ESCs_Mouse2.03287762
27REST_21632747_ChIP-Seq_MESCs_Mouse2.02554027
28RNF2_27304074_Chip-Seq_ESCs_Mouse2.02323130
29RARB_27405468_Chip-Seq_BRAIN_Mouse2.00952072
30* GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.00421280
31ELK1_19687146_ChIP-ChIP_HELA_Human1.95075686
32AR_21572438_ChIP-Seq_LNCaP_Human1.93766871
33FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.92895674
34AR_21909140_ChIP-Seq_LNCAP_Human1.92351079
35MTF2_20144788_ChIP-Seq_MESCs_Mouse1.90239218
36SMAD_19615063_ChIP-ChIP_OVARY_Human1.83364917
37* SMAD4_21799915_ChIP-Seq_A2780_Human1.82887958
38CTBP1_25329375_ChIP-Seq_LNCAP_Human1.79959883
39RBPJ_22232070_ChIP-Seq_NCS_Mouse1.79382804
40EST1_17652178_ChIP-ChIP_JURKAT_Human1.77628273
41SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.76932324
42* FLI1_27457419_Chip-Seq_LIVER_Mouse1.76540073
43IGF1R_20145208_ChIP-Seq_DFB_Human1.75516644
44CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.69408941
45* P300_19829295_ChIP-Seq_ESCs_Human1.69032282
46GABP_17652178_ChIP-ChIP_JURKAT_Human1.68459648
47SUZ12_27294783_Chip-Seq_ESCs_Mouse1.67971846
48SMAD3_21741376_ChIP-Seq_EPCs_Human1.64300671
49* ZFP57_27257070_Chip-Seq_ESCs_Mouse1.63564163
50SOX2_16153702_ChIP-ChIP_HESCs_Human1.63132928
51NANOG_16153702_ChIP-ChIP_HESCs_Human1.62783986
52NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.60071840
53RNF2_27304074_Chip-Seq_NSC_Mouse1.59881051
54VDR_22108803_ChIP-Seq_LS180_Human1.59875922
55E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.59392460
56EZH2_27294783_Chip-Seq_ESCs_Mouse1.59132838
57BMI1_23680149_ChIP-Seq_NPCS_Mouse1.57903401
58CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.57328325
59POU3F2_20337985_ChIP-ChIP_501MEL_Human1.57317891
60REST_18959480_ChIP-ChIP_MESCs_Mouse1.57007064
61* RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.56914601
62SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.56182449
63CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.55416052
64MYC_18555785_ChIP-Seq_MESCs_Mouse1.51853999
65* CBX2_27304074_Chip-Seq_ESCs_Mouse1.46883432
66PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.46639332
67DROSHA_22980978_ChIP-Seq_HELA_Human1.45099443
68HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.44094555
69OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.43590696
70EWS_26573619_Chip-Seq_HEK293_Human1.43235521
71TOP2B_26459242_ChIP-Seq_MCF-7_Human1.42612742
72ZNF217_24962896_ChIP-Seq_MCF-7_Human1.42185046
73GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.42093496
74PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.41387029
75* SOX2_21211035_ChIP-Seq_LN229_Gbm1.40205792
76* PIAS1_25552417_ChIP-Seq_VCAP_Human1.38120862
77PADI4_21655091_ChIP-ChIP_MCF-7_Human1.37386621
78* TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.36322592
79* MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.35689285
80MYC_18940864_ChIP-ChIP_HL60_Human1.35059698
81* STAT3_23295773_ChIP-Seq_U87_Human1.33999058
82* PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.32983695
83* AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.32809805
84TP53_16413492_ChIP-PET_HCT116_Human1.32548934
85E2F1_21310950_ChIP-Seq_MCF-7_Human1.32225712
86* PCGF2_27294783_Chip-Seq_ESCs_Mouse1.31290346
87NACC1_18358816_ChIP-ChIP_MESCs_Mouse1.30488959
88WT1_19549856_ChIP-ChIP_CCG9911_Human1.29782972
89* AR_25329375_ChIP-Seq_VCAP_Human1.29645221
90ARNT_22903824_ChIP-Seq_MCF-7_Human1.29245800
91* YAP1_20516196_ChIP-Seq_MESCs_Mouse1.28317856
92KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.28084058
93KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.28084058
94KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.28084058
95HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.27261953
96YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.27164303
97* RING1B_27294783_Chip-Seq_NPCs_Mouse1.26091538
98* SOX9_26525672_Chip-Seq_HEART_Mouse1.25670922
99AHR_22903824_ChIP-Seq_MCF-7_Human1.25063415
100EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.23356846
101CREB1_15753290_ChIP-ChIP_HEK293T_Human1.22476179
102SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.22351612
103AR_19668381_ChIP-Seq_PC3_Human1.21559704
104POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.20659709
105TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.20659709
106TCF4_23295773_ChIP-Seq_U87_Human1.20500809
107SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.20311387
108WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.19341347
109* RING1B_27294783_Chip-Seq_ESCs_Mouse1.18777442
110* MYC_19030024_ChIP-ChIP_MESCs_Mouse1.18435630
111TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.18057177
112IKZF1_21737484_ChIP-ChIP_HCT116_Human1.17712405
113NR3C1_23031785_ChIP-Seq_PC12_Mouse1.16855816
114UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.14942165
115MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.14852232
116* TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.13805539
117TP53_18474530_ChIP-ChIP_U2OS_Human1.13208599
118TBX3_20139965_ChIP-Seq_ESCs_Mouse1.12205970
119CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.12090217
120MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.11891962
121TBX3_20139965_ChIP-Seq_MESCs_Mouse1.11515014
122MYCN_18555785_ChIP-Seq_MESCs_Mouse1.11019503
123P53_22127205_ChIP-Seq_FIBROBLAST_Human1.10685560
124* EZH2_27294783_Chip-Seq_NPCs_Mouse1.10563410
125* NANOG_18555785_Chip-Seq_ESCs_Mouse1.09075159
126* RUNX2_22187159_ChIP-Seq_PCA_Human1.08408240
127RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.07816759
128TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.06861736
129* TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.06612354
130WT1_25993318_ChIP-Seq_PODOCYTE_Human1.06531276
131* SOX2_18555785_ChIP-Seq_MESCs_Mouse1.06519355
132* MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.06446277
133PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.05240847
134ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.04499080
135ZNF274_21170338_ChIP-Seq_K562_Hela1.04489545
136SOX2_19030024_ChIP-ChIP_MESCs_Mouse1.04430567
137CEBPB_26923725_Chip-Seq_MESODERM_Mouse1.04151846
138FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.04119888
139IRF1_19129219_ChIP-ChIP_H3396_Human1.03787673
140NELFA_20434984_ChIP-Seq_ESCs_Mouse1.03087426
141* JUN_21703547_ChIP-Seq_K562_Human1.02603667
142MYC_19079543_ChIP-ChIP_MESCs_Mouse1.01392485
143* TCF4_18268006_ChIP-ChIP_LS174T_Human1.00701261
144* STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse1.00297475
145GATA1_26923725_Chip-Seq_HPCs_Mouse0.99172296
146* PCGF2_27294783_Chip-Seq_NPCs_Mouse0.98273072
147* POU5F1_18347094_ChIP-ChIP_MESCs_Mouse0.98242926
148POU5F1_16153702_ChIP-ChIP_HESCs_Human0.97771856
149* E2F1_18555785_Chip-Seq_ESCs_Mouse0.97710329
150* SUZ12_27294783_Chip-Seq_NPCs_Mouse0.97421013
151PRDM5_23873026_ChIP-Seq_MEFs_Mouse0.97223560
152* NR3C1_21868756_ChIP-Seq_MCF10A_Human0.97215690
153GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse0.96634551
154* KDM5B_21448134_ChIP-Seq_MESCs_Mouse0.96452808
155ERG_21242973_ChIP-ChIP_JURKAT_Human0.96294301
156POU5F1_18358816_ChIP-ChIP_MESCs_Mouse0.96239526
157TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.95090395
158* FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse0.94057926
159TCF3_18692474_ChIP-Seq_MESCs_Mouse0.92970231

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity5.46693291
2MP0003880_abnormal_central_pattern4.51728858
3MP0003635_abnormal_synaptic_transmissio3.36321364
4MP0003941_abnormal_skin_development3.27791896
5MP0010094_abnormal_chromosome_stability3.08276547
6MP0004270_analgesia3.07223898
7MP0008057_abnormal_DNA_replication2.96911025
8MP0002063_abnormal_learning/memory/cond2.83585160
9MP0008058_abnormal_DNA_repair2.77833705
10MP0009745_abnormal_behavioral_response2.62730197
11MP0001968_abnormal_touch/_nociception2.55786894
12MP0003693_abnormal_embryo_hatching2.46786222
13MP0004957_abnormal_blastocyst_morpholog2.40399957
14MP0002064_seizures2.34548954
15MP0002572_abnormal_emotion/affect_behav2.29382442
16MP0003787_abnormal_imprinting2.23060544
17MP0009046_muscle_twitch2.19304871
18MP0003111_abnormal_nucleus_morphology2.19193940
19MP0003122_maternal_imprinting2.16464151
20MP0002734_abnormal_mechanical_nocicepti2.11008364
21MP0009780_abnormal_chondrocyte_physiolo2.10563654
22MP0001293_anophthalmia2.09950194
23MP0002736_abnormal_nociception_after2.03013902
24MP0008932_abnormal_embryonic_tissue1.95536621
25MP0001486_abnormal_startle_reflex1.95111116
26MP0003718_maternal_effect1.94400140
27MP0000778_abnormal_nervous_system1.90588772
28MP0003077_abnormal_cell_cycle1.84909054
29MP0003121_genomic_imprinting1.84001760
30MP0001188_hyperpigmentation1.83345939
31MP0003123_paternal_imprinting1.80326709
32MP0002272_abnormal_nervous_system1.78421669
33MP0005423_abnormal_somatic_nervous1.76869412
34MP0008007_abnormal_cellular_replicative1.76746015
35MP0003567_abnormal_fetal_cardiomyocyte1.74002805
36MP0005623_abnormal_meninges_morphology1.71909308
37MP0002938_white_spotting1.61211525
38MP0002254_reproductive_system_inflammat1.59360125
39MP0005646_abnormal_pituitary_gland1.55587221
40MP0009672_abnormal_birth_weight1.55169159
41MP0002184_abnormal_innervation1.54645701
42MP0001501_abnormal_sleep_pattern1.53101440
43MP0002557_abnormal_social/conspecific_i1.52329830
44MP0002067_abnormal_sensory_capabilities1.51495496
45MP0001440_abnormal_grooming_behavior1.41966317
46MP0002697_abnormal_eye_size1.41731047
47MP0002234_abnormal_pharynx_morphology1.41363527
48MP0008877_abnormal_DNA_methylation1.40728857
49MP0001286_abnormal_eye_development1.40321983
50MP0004811_abnormal_neuron_physiology1.40085804
51MP0005386_behavior/neurological_phenoty1.39661780
52MP0004924_abnormal_behavior1.39661780
53MP0006072_abnormal_retinal_apoptosis1.39079082
54MP0002084_abnormal_developmental_patter1.37402458
55MP0000569_abnormal_digit_pigmentation1.36954643
56MP0003890_abnormal_embryonic-extraembry1.36504723
57MP0002735_abnormal_chemical_nociception1.35879754
58MP0009697_abnormal_copulation1.35046681
59MP0003879_abnormal_hair_cell1.27103379
60MP0004147_increased_porphyrin_level1.25652529
61MP0002085_abnormal_embryonic_tissue1.24387390
62MP0005171_absent_coat_pigmentation1.23787421
63MP0002733_abnormal_thermal_nociception1.21086136
64MP0005394_taste/olfaction_phenotype1.20694435
65MP0005499_abnormal_olfactory_system1.20694435
66MP0001730_embryonic_growth_arrest1.19477000
67MP0001970_abnormal_pain_threshold1.18156175
68MP0009703_decreased_birth_body1.18064141
69MP0001299_abnormal_eye_distance/1.17402402
70MP0000955_abnormal_spinal_cord1.15233944
71MP0005380_embryogenesis_phenotype1.14622061
72MP0001672_abnormal_embryogenesis/_devel1.14622061
73MP0002152_abnormal_brain_morphology1.14205324
74MP0005409_darkened_coat_color1.13279448
75MP0010307_abnormal_tumor_latency1.13172511
76MP0002882_abnormal_neuron_morphology1.11833321
77MP0008569_lethality_at_weaning1.11570407
78MP0000631_abnormal_neuroendocrine_gland1.08694536
79MP0010352_gastrointestinal_tract_polyps1.08008501
80MP0003861_abnormal_nervous_system1.07712822
81MP0004133_heterotaxia1.07661482
82MP0001984_abnormal_olfaction1.07592170
83MP0002653_abnormal_ependyma_morphology1.06312018
84MP0001697_abnormal_embryo_size1.05940504
85MP0004197_abnormal_fetal_growth/weight/1.05886785
86MP0001485_abnormal_pinna_reflex1.04511669
87MP0002111_abnormal_tail_morphology1.03748519
88MP0004484_altered_response_of1.02841190
89MP0000647_abnormal_sebaceous_gland1.01627220
90MP0002822_catalepsy1.01517495
91MP0006292_abnormal_olfactory_placode0.98385193
92MP0010030_abnormal_orbit_morphology0.97888081
93MP0000579_abnormal_nail_morphology0.97416141
94MP0002090_abnormal_vision0.96402891
95MP0002066_abnormal_motor_capabilities/c0.96304500
96MP0000350_abnormal_cell_proliferation0.95935809
97MP0002088_abnormal_embryonic_growth/wei0.95704270
98MP0005253_abnormal_eye_physiology0.95276800
99MP0004858_abnormal_nervous_system0.95157113
100MP0003984_embryonic_growth_retardation0.94721865
101MP0001529_abnormal_vocalization0.93301274
102MP0005391_vision/eye_phenotype0.92877103
103MP0003136_yellow_coat_color0.92253454
104MP0002249_abnormal_larynx_morphology0.91576234
105MP0004233_abnormal_muscle_weight0.91084242
106MP0000537_abnormal_urethra_morphology0.90912581
107MP0000516_abnormal_urinary_system0.90668455
108MP0005367_renal/urinary_system_phenotyp0.90668455
109MP0006276_abnormal_autonomic_nervous0.89285702
110MP0003786_premature_aging0.89270341
111MP0010234_abnormal_vibrissa_follicle0.89095384
112MP0003755_abnormal_palate_morphology0.87414568
113MP0003385_abnormal_body_wall0.86893879
114MP0010678_abnormal_skin_adnexa0.85889080
115MP0004272_abnormal_basement_membrane0.85888000
116MP0002092_abnormal_eye_morphology0.85843634
117MP0000428_abnormal_craniofacial_morphol0.84999615
118MP0003119_abnormal_digestive_system0.84993470
119MP0001905_abnormal_dopamine_level0.84824021
120MP0002102_abnormal_ear_morphology0.84388740
121MP0005167_abnormal_blood-brain_barrier0.84108612
122MP0005551_abnormal_eye_electrophysiolog0.84059697
123MP0002210_abnormal_sex_determination0.83108326
124MP0004885_abnormal_endolymph0.81982274
125MP0001929_abnormal_gametogenesis0.80780547
126MP0006054_spinal_hemorrhage0.80695997
127MP0002080_prenatal_lethality0.80458636
128MP0000432_abnormal_head_morphology0.80322572
129MP0001177_atelectasis0.79876314
130MP0000383_abnormal_hair_follicle0.78943248
131MP0003937_abnormal_limbs/digits/tail_de0.77531409
132MP0003938_abnormal_ear_development0.77316251
133MP0004215_abnormal_myocardial_fiber0.76927027
134MP0000762_abnormal_tongue_morphology0.76808913
135MP0003935_abnormal_craniofacial_develop0.76793178
136MP0000049_abnormal_middle_ear0.76176504
137MP0003633_abnormal_nervous_system0.76163149
138MP0003631_nervous_system_phenotype0.75161997
139MP0001145_abnormal_male_reproductive0.73834690
140MP0000653_abnormal_sex_gland0.73385090
141MP0001963_abnormal_hearing_physiology0.72347715
142MP0005187_abnormal_penis_morphology0.71406839
143MP0000534_abnormal_ureter_morphology0.71021628
144MP0002751_abnormal_autonomic_nervous0.70078757
145MP0002909_abnormal_adrenal_gland0.69171173
146MP0002116_abnormal_craniofacial_bone0.68840262
147MP0000427_abnormal_hair_cycle0.68598563
148MP0002081_perinatal_lethality0.68533164
149MP0001943_abnormal_respiration0.65494062
150MP0008789_abnormal_olfactory_epithelium0.64696730
151MP0003942_abnormal_urinary_system0.64041141
152MP0005248_abnormal_Harderian_gland0.63617289
153MP0004085_abnormal_heartbeat0.63202726
154MP0002752_abnormal_somatic_nervous0.62943846
155MP0009250_abnormal_appendicular_skeleto0.61080655
156MP0003632_abnormal_nervous_system0.59447744
157MP0002233_abnormal_nose_morphology0.58630151

Predicted human phenotypes

RankGene SetZ-score
1Focal motor seizures (HP:0011153)5.89677017
2Epileptic encephalopathy (HP:0200134)4.41569497
3Focal seizures (HP:0007359)4.21225318
4Atonic seizures (HP:0010819)4.05869173
5Myokymia (HP:0002411)3.85597350
6Colon cancer (HP:0003003)3.83530183
7Febrile seizures (HP:0002373)3.49857440
8Abnormal lung lobation (HP:0002101)3.32446410
9Ependymoma (HP:0002888)3.26229330
10Abnormality of chromosome stability (HP:0003220)3.21713896
11Chromosomal breakage induced by crosslinking agents (HP:0003221)3.20940679
12Broad-based gait (HP:0002136)3.18599067
13Meckel diverticulum (HP:0002245)3.10271636
14Chromsome breakage (HP:0040012)3.07085578
15Absence seizures (HP:0002121)2.98758435
16Abnormality of the ileum (HP:0001549)2.93090720
17Aplasia/Hypoplasia of the uvula (HP:0010293)2.89295709
18Progressive cerebellar ataxia (HP:0002073)2.88607106
19Abnormality of the labia minora (HP:0012880)2.88464166
20Embryonal renal neoplasm (HP:0011794)2.82808774
21Hyperventilation (HP:0002883)2.80994018
22Rhabdomyosarcoma (HP:0002859)2.80761914
23Glioma (HP:0009733)2.69962368
24Dialeptic seizures (HP:0011146)2.69554155
25Bifid tongue (HP:0010297)2.69069170
26Visual hallucinations (HP:0002367)2.68960893
27Medulloblastoma (HP:0002885)2.57381019
28Septo-optic dysplasia (HP:0100842)2.57247020
29Cortical dysplasia (HP:0002539)2.57001237
30Pancreatic islet-cell hyperplasia (HP:0004510)2.55438445
31Duodenal stenosis (HP:0100867)2.52621258
32Small intestinal stenosis (HP:0012848)2.52621258
33Amblyopia (HP:0000646)2.51654867
34Gaze-evoked nystagmus (HP:0000640)2.48799954
35Impaired vibration sensation in the lower limbs (HP:0002166)2.47941789
36Annular pancreas (HP:0001734)2.47669804
37Poor eye contact (HP:0000817)2.47086738
38Intestinal atresia (HP:0011100)2.45085558
39Drooling (HP:0002307)2.45034702
40Excessive salivation (HP:0003781)2.45034702
41Agnosia (HP:0010524)2.42099209
42Abnormality of the duodenum (HP:0002246)2.41166049
43Abnormality of the preputium (HP:0100587)2.40395179
44Generalized tonic-clonic seizures (HP:0002069)2.39671527
45Insidious onset (HP:0003587)2.34369406
46Termporal pattern (HP:0011008)2.34369406
47Spastic diplegia (HP:0001264)2.24915616
48Oligodactyly (hands) (HP:0001180)2.24699674
49Urinary bladder sphincter dysfunction (HP:0002839)2.23944872
50Impaired smooth pursuit (HP:0007772)2.21665878
51Birth length less than 3rd percentile (HP:0003561)2.20706193
52Genetic anticipation (HP:0003743)2.20529717
53Ectopic kidney (HP:0000086)2.20463284
54Absent radius (HP:0003974)2.16331016
55Stenosis of the external auditory canal (HP:0000402)2.15706413
56Gonadotropin excess (HP:0000837)2.12776926
57Abnormal hair whorl (HP:0010721)2.11459544
58Protruding tongue (HP:0010808)2.11141389
59Aplasia involving forearm bones (HP:0009822)2.04631882
60Absent forearm bone (HP:0003953)2.04631882
61Absent eyebrow (HP:0002223)2.04134981
62Hypoglycemic seizures (HP:0002173)2.04050785
63Bilateral microphthalmos (HP:0007633)2.01017224
64Biliary tract neoplasm (HP:0100574)2.01016213
65Hepatoblastoma (HP:0002884)2.00834642
66Papillary thyroid carcinoma (HP:0002895)2.00508004
67Widely spaced teeth (HP:0000687)2.00409007
68Volvulus (HP:0002580)1.98899313
69Increased nuchal translucency (HP:0010880)1.97799452
70Hydroureter (HP:0000072)1.96839825
71Sloping forehead (HP:0000340)1.96683487
72Action tremor (HP:0002345)1.96646314
73Triphalangeal thumb (HP:0001199)1.96337613
74Neoplasm of striated muscle (HP:0009728)1.95990271
75Abnormality of the lower motor neuron (HP:0002366)1.94357086
76Dysdiadochokinesis (HP:0002075)1.94164877
77Shoulder girdle muscle weakness (HP:0003547)1.93264516
78Neoplasm of the oral cavity (HP:0100649)1.92463486
79Stereotypic behavior (HP:0000733)1.91273419
80Absent speech (HP:0001344)1.89838726
81Urethral obstruction (HP:0000796)1.88439176
82Epileptiform EEG discharges (HP:0011182)1.87439967
83Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)1.86482617
84Short 4th metacarpal (HP:0010044)1.86482617
85Abnormality of methionine metabolism (HP:0010901)1.86017467
86Gastrointestinal atresia (HP:0002589)1.85784960
87Renal hypoplasia (HP:0000089)1.85722268
88Hyperglycinemia (HP:0002154)1.85649582
89Abnormal social behavior (HP:0012433)1.85427650
90Impaired social interactions (HP:0000735)1.85427650
91Breast carcinoma (HP:0003002)1.85413747
92Papilledema (HP:0001085)1.84803147
93Truncal ataxia (HP:0002078)1.84786387
94Abnormality of ocular smooth pursuit (HP:0000617)1.84656003
95Abnormality of aspartate family amino acid metabolism (HP:0010899)1.84593630
96Abnormality of the septum pellucidum (HP:0007375)1.84435640
97Abnormality of the carotid arteries (HP:0005344)1.82257732
98Genital tract atresia (HP:0001827)1.82196958
99Hemiparesis (HP:0001269)1.81248934
100Dandy-Walker malformation (HP:0001305)1.80617248
101Neoplasm of the colon (HP:0100273)1.79549974
102Neoplasm of the adrenal cortex (HP:0100641)1.79163715
103Absent septum pellucidum (HP:0001331)1.78969575
104Vaginal atresia (HP:0000148)1.78546032
105Ankyloglossia (HP:0010296)1.78089399
106Hypoplastic female external genitalia (HP:0012815)1.77703750
107Anophthalmia (HP:0000528)1.76769668
108Gastroesophageal reflux (HP:0002020)1.76134795
109Dysmetric saccades (HP:0000641)1.75883951
110Intellectual disability, profound (HP:0002187)1.75206645
111Esophageal atresia (HP:0002032)1.75185878
112Incomplete penetrance (HP:0003829)1.74639885
113Clitoromegaly (HP:0000057)1.74615774
114Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.74297838
115Abnormality of the nasal septum (HP:0000419)1.74097097
116Myelomeningocele (HP:0002475)1.72650987
117Inability to walk (HP:0002540)1.72303259
118Absent frontal sinuses (HP:0002688)1.72075454
119Ovarian neoplasm (HP:0100615)1.71720050
120Clubbing of toes (HP:0100760)1.70457787
121Urinary urgency (HP:0000012)1.70320147
122Neoplasm of the adrenal gland (HP:0100631)1.70070893
123Hyperthyroidism (HP:0000836)1.69007031
124Scrotal hypoplasia (HP:0000046)1.68427532
125Abnormality of binocular vision (HP:0011514)1.68086603
126Diplopia (HP:0000651)1.68086603
127Abnormality of the clitoris (HP:0000056)1.68038668
128Hyperinsulinemic hypoglycemia (HP:0000825)1.67023921
129Aplasia/Hypoplasia of the sternum (HP:0006714)1.66284046
130Skull defect (HP:0001362)1.66051056
131Malignant gastrointestinal tract tumors (HP:0006749)1.65513292
132Gastrointestinal carcinoma (HP:0002672)1.65513292
133Abnormality of serum amino acid levels (HP:0003112)1.65465385
134Methylmalonic acidemia (HP:0002912)1.65449450
135Fetal akinesia sequence (HP:0001989)1.65074700
136Pointed chin (HP:0000307)1.64784782
137EEG with generalized epileptiform discharges (HP:0011198)1.64442156
138Median cleft lip (HP:0000161)1.64258369
139Optic nerve hypoplasia (HP:0000609)1.64005895
140Inappropriate behavior (HP:0000719)1.63928414
141Abnormality of salivation (HP:0100755)1.61435706
142Impaired vibratory sensation (HP:0002495)1.61423685
143Aqueductal stenosis (HP:0002410)1.60492214
144Cutaneous finger syndactyly (HP:0010554)1.59522522
145Depression (HP:0000716)1.59495699
146Abnormality of chromosome segregation (HP:0002916)1.59133508
147Hypoplastic pelvis (HP:0008839)1.56939054
148Embryonal neoplasm (HP:0002898)1.56610661
149Cupped ear (HP:0000378)1.55812267
150Breast aplasia (HP:0100783)1.55732791
151Micropenis (HP:0000054)1.55712809
152Neoplasm of the small intestine (HP:0100833)1.55056089
153Abnormality of hair growth rate (HP:0011363)1.54537927
154Slow-growing hair (HP:0002217)1.54537927
155Uterine neoplasm (HP:0010784)1.54485089
156Abnormality of the frontal sinuses (HP:0002687)1.53549180
157Sensory axonal neuropathy (HP:0003390)1.52936609
158Microglossia (HP:0000171)1.52735387
159Relative macrocephaly (HP:0004482)1.52490720
160Horseshoe kidney (HP:0000085)1.52392520
161Specific learning disability (HP:0001328)1.52252991
162Dysmetria (HP:0001310)1.51977077
163Oligodactyly (HP:0012165)1.51800947
164Abnormal eating behavior (HP:0100738)1.51220649
165Thickened helices (HP:0000391)1.50287849
166Mutism (HP:0002300)1.49345489
167Hypsarrhythmia (HP:0002521)1.49285290
168Supernumerary spleens (HP:0009799)1.49133176
169Overgrowth (HP:0001548)1.47776959
170Blue irides (HP:0000635)1.47709613
171Shawl scrotum (HP:0000049)1.47467707
172Labial hypoplasia (HP:0000066)1.45790472
173Postural instability (HP:0002172)1.45454574
174Pili torti (HP:0003777)1.44729396
175Trigonocephaly (HP:0000243)1.44534572
176Cutaneous syndactyly (HP:0012725)1.44214706
177Anxiety (HP:0000739)1.44115891
178Autism (HP:0000717)1.43432890
179Astrocytoma (HP:0009592)1.41944925
180Abnormality of the astrocytes (HP:0100707)1.41944925
181Small hand (HP:0200055)1.41388687
182Gait imbalance (HP:0002141)1.41203722
183Abnormality of the corticospinal tract (HP:0002492)1.39838870
184Nephroblastoma (Wilms tumor) (HP:0002667)1.39290589

Predicted kinase interactions (KEA)

RankGene SetZ-score
1EPHA44.30668339
2CASK3.87892595
3NTRK33.55812874
4MAP3K43.25809954
5MAP3K93.02629458
6CCNB13.01503199
7BMPR1B2.79929893
8DAPK22.72407288
9MAP2K72.72185549
10BUB12.68728264
11WNK32.62855663
12TRIM282.55983475
13PLK22.41822779
14SRPK12.25622894
15ZAK2.19596421
16NUAK12.04076884
17DAPK12.01281191
18KSR11.93285030
19AKT31.90348777
20TAF11.89918544
21MAP3K121.89506677
22MARK11.85529033
23MINK11.85136716
24MAP2K41.82017896
25EIF2AK31.78267152
26PRKD31.77608026
27CDK191.77402994
28PLK41.76930516
29PAK61.74518142
30NTRK21.73922729
31PNCK1.72507767
32PBK1.70701933
33WEE11.65748092
34ACVR1B1.64242759
35BRSK21.53707164
36KSR21.45972932
37PLK11.42118936
38CAMKK11.33187591
39MAPK131.32702700
40LATS21.31857377
41VRK11.27994621
42SGK21.27151661
43TGFBR11.18747333
44STK38L1.16177377
45RIPK41.15974095
46PLK31.15682845
47MST41.11414338
48CSNK1G11.08519135
49EIF2AK11.08285493
50CDK51.07735685
51BRD41.05550816
52STK381.05177739
53BMPR21.04104503
54VRK21.03345058
55TAOK10.99575184
56PTK2B0.96498734
57SGK2230.94932877
58SGK4940.94932877
59PRKCG0.94852670
60BRAF0.94600474
61TSSK60.94464656
62TYRO30.92006381
63ATR0.91816154
64STK390.90743107
65EIF2AK20.90083171
66TIE10.88392004
67PRPF4B0.88229071
68NTRK10.87169229
69MAP3K60.87051130
70GRK50.86436092
71CHEK20.86376679
72RAF10.85759719
73DYRK20.84666431
74ATM0.83954063
75LATS10.83475005
76MAP4K20.80146197
77STK30.79753828
78CDC70.79633088
79SGK30.78598419
80ARAF0.78563967
81CDK180.77415015
82SIK30.77219029
83INSRR0.76946937
84BCR0.75202866
85DYRK30.73913528
86CSNK1G20.73466136
87NEK10.72102753
88OXSR10.72012981
89CDK150.70890233
90SIK20.68971005
91CAMK2A0.68854426
92CDK140.68821549
93ERBB30.68799886
94NLK0.68639988
95DYRK1A0.67156901
96SGK10.67025619
97MAPK70.65060604
98CAMKK20.64849489
99MKNK20.63209171
100MAP3K20.62676650
101CAMK1G0.62262814
102AURKB0.62238135
103ERBB40.62103757
104FLT30.60929355
105CHEK10.59867519
106GRK10.58710792
107CDK11A0.58604965
108NEK20.57988213
109UHMK10.57871056
110STK110.57187519
111FGFR10.55459760
112MARK20.52366691
113CDK30.51342583
114RPS6KA40.51247668
115PRKDC0.49385638
116CAMK10.47415107
117RET0.47326626
118ALK0.47235031
119MKNK10.47075894
120NEK60.46193576
121PASK0.46172854
122CDK10.45672568
123MET0.45352681
124YES10.45201832
125MAP3K130.45169402
126CAMK40.44729637
127NME10.44067991
128CAMK2B0.42130888
129CSNK1A1L0.42042303
130STK160.41907578
131FGFR20.41831735
132EPHB20.41638583
133TTK0.39227701
134MAPK100.38794318
135DMPK0.37590315
136FGR0.37409086
137CDK20.37240978
138TNIK0.37071390
139RPS6KA30.36430326
140CDK90.36265954
141PRKCE0.36169009
142CSNK1E0.35281113
143PINK10.35110608
144CSNK1G30.34849518
145CDK80.34780038
146FRK0.32767160
147BRSK10.32262882
148FER0.31933189
149PAK30.31885620
150PDK20.31882246
151CSNK1D0.30596823
152CDK70.29801699

Predicted pathways (KEGG)

RankGene SetZ-score
1Non-homologous end-joining_Homo sapiens_hsa034504.01549400
2Mismatch repair_Homo sapiens_hsa034303.48433255
3Nicotine addiction_Homo sapiens_hsa050333.35718869
4DNA replication_Homo sapiens_hsa030302.92238394
5Long-term potentiation_Homo sapiens_hsa047202.70312707
6Synaptic vesicle cycle_Homo sapiens_hsa047212.65586130
7Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.65212203
8Homologous recombination_Homo sapiens_hsa034402.52672970
9Fanconi anemia pathway_Homo sapiens_hsa034602.46467850
10Protein export_Homo sapiens_hsa030602.43318240
11Amphetamine addiction_Homo sapiens_hsa050312.36227115
12Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.36005804
13RNA transport_Homo sapiens_hsa030132.34176293
14Circadian entrainment_Homo sapiens_hsa047132.33596691
15Olfactory transduction_Homo sapiens_hsa047402.32272442
16Glutamatergic synapse_Homo sapiens_hsa047242.23284234
17Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009702.21538297
18Basal transcription factors_Homo sapiens_hsa030222.18178149
19Morphine addiction_Homo sapiens_hsa050322.09156418
20Proteasome_Homo sapiens_hsa030502.00583064
21GABAergic synapse_Homo sapiens_hsa047271.98083264
22Dopaminergic synapse_Homo sapiens_hsa047281.93768984
23Vitamin B6 metabolism_Homo sapiens_hsa007501.90350754
24Propanoate metabolism_Homo sapiens_hsa006401.86145162
25Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.84352310
26Spliceosome_Homo sapiens_hsa030401.81325373
27Cysteine and methionine metabolism_Homo sapiens_hsa002701.80968062
28Long-term depression_Homo sapiens_hsa047301.80675327
29Steroid biosynthesis_Homo sapiens_hsa001001.78901677
30Salivary secretion_Homo sapiens_hsa049701.78722365
31Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.77058134
32Nucleotide excision repair_Homo sapiens_hsa034201.72022627
33Oxytocin signaling pathway_Homo sapiens_hsa049211.68234207
34Gastric acid secretion_Homo sapiens_hsa049711.65218509
35Insulin secretion_Homo sapiens_hsa049111.64372319
36RNA polymerase_Homo sapiens_hsa030201.64085335
37Renin secretion_Homo sapiens_hsa049241.61236068
38Oocyte meiosis_Homo sapiens_hsa041141.60518338
39Aldosterone synthesis and secretion_Homo sapiens_hsa049251.56624978
40Base excision repair_Homo sapiens_hsa034101.54179361
41Cholinergic synapse_Homo sapiens_hsa047251.53849842
42Axon guidance_Homo sapiens_hsa043601.49484841
43Serotonergic synapse_Homo sapiens_hsa047261.48027057
44Taste transduction_Homo sapiens_hsa047421.46777333
45GnRH signaling pathway_Homo sapiens_hsa049121.45007652
46Melanogenesis_Homo sapiens_hsa049161.44332628
47Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.43296816
48Gap junction_Homo sapiens_hsa045401.42777716
49Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.40762173
50Calcium signaling pathway_Homo sapiens_hsa040201.37893695
51Cocaine addiction_Homo sapiens_hsa050301.35215425
52One carbon pool by folate_Homo sapiens_hsa006701.32067116
53Selenocompound metabolism_Homo sapiens_hsa004501.31894251
54Collecting duct acid secretion_Homo sapiens_hsa049661.29688276
55Glioma_Homo sapiens_hsa052141.29048406
56Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.27892102
57Estrogen signaling pathway_Homo sapiens_hsa049151.26498399
58Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.23666642
59cAMP signaling pathway_Homo sapiens_hsa040241.20843563
60Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.19858091
61Pyruvate metabolism_Homo sapiens_hsa006201.17501296
62Wnt signaling pathway_Homo sapiens_hsa043101.17038446
63Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.14566165
64ErbB signaling pathway_Homo sapiens_hsa040121.13328592
65Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.12627451
66Progesterone-mediated oocyte maturation_Homo sapiens_hsa049141.08915142
67Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.07190361
68Dorso-ventral axis formation_Homo sapiens_hsa043201.07103598
69cGMP-PKG signaling pathway_Homo sapiens_hsa040221.05839110
702-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.04129529
71Hippo signaling pathway_Homo sapiens_hsa043901.01058464
72p53 signaling pathway_Homo sapiens_hsa041150.98391840
73Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.98339397
74Colorectal cancer_Homo sapiens_hsa052100.97605729
75Fatty acid elongation_Homo sapiens_hsa000620.97458324
76Purine metabolism_Homo sapiens_hsa002300.96947886
77Phosphatidylinositol signaling system_Homo sapiens_hsa040700.95699251
78Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.95227244
79Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.93549473
80Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.93449361
81Hedgehog signaling pathway_Homo sapiens_hsa043400.93040931
82Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.92593049
83MAPK signaling pathway_Homo sapiens_hsa040100.91931527
84Rap1 signaling pathway_Homo sapiens_hsa040150.87738865
85Thyroid hormone signaling pathway_Homo sapiens_hsa049190.87715964
86Vibrio cholerae infection_Homo sapiens_hsa051100.87505503
87Basal cell carcinoma_Homo sapiens_hsa052170.87373010
88Biosynthesis of amino acids_Homo sapiens_hsa012300.85625985
89Vascular smooth muscle contraction_Homo sapiens_hsa042700.85447295
90Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.85184517
91Adherens junction_Homo sapiens_hsa045200.83135016
92Ras signaling pathway_Homo sapiens_hsa040140.82232269
93Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.81317338
94Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.81240835
95Dilated cardiomyopathy_Homo sapiens_hsa054140.79822790
96Pyrimidine metabolism_Homo sapiens_hsa002400.77249316
97Choline metabolism in cancer_Homo sapiens_hsa052310.76438842
98Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.76283326
99Type II diabetes mellitus_Homo sapiens_hsa049300.75926953
100VEGF signaling pathway_Homo sapiens_hsa043700.73915147
101Endometrial cancer_Homo sapiens_hsa052130.73370448
102Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.72547799
103Renal cell carcinoma_Homo sapiens_hsa052110.72294411
104Alcoholism_Homo sapiens_hsa050340.70565294
105Neurotrophin signaling pathway_Homo sapiens_hsa047220.69468525
106Phototransduction_Homo sapiens_hsa047440.69280478
107Circadian rhythm_Homo sapiens_hsa047100.67458503
108Phospholipase D signaling pathway_Homo sapiens_hsa040720.67232332
109mTOR signaling pathway_Homo sapiens_hsa041500.66178719
110TGF-beta signaling pathway_Homo sapiens_hsa043500.64193527
111Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.63756003
112Thyroid hormone synthesis_Homo sapiens_hsa049180.62798759
113Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.62444311
114Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.60397947
115Carbon metabolism_Homo sapiens_hsa012000.59721872
116mRNA surveillance pathway_Homo sapiens_hsa030150.58547575
117Glucagon signaling pathway_Homo sapiens_hsa049220.58509378
118Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.57615291
119Melanoma_Homo sapiens_hsa052180.57385864
120Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.56088953
121Ovarian steroidogenesis_Homo sapiens_hsa049130.55825965
122Lysine degradation_Homo sapiens_hsa003100.55608927
123Cell cycle_Homo sapiens_hsa041100.55174368
124Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.55137427
125Tight junction_Homo sapiens_hsa045300.54812139
126Butanoate metabolism_Homo sapiens_hsa006500.54758418
127Non-small cell lung cancer_Homo sapiens_hsa052230.53255355
128Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.53165114
129MicroRNAs in cancer_Homo sapiens_hsa052060.52240077
130Vitamin digestion and absorption_Homo sapiens_hsa049770.50621411
131Thyroid cancer_Homo sapiens_hsa052160.50457372
132Cardiac muscle contraction_Homo sapiens_hsa042600.50319180
133Sphingolipid signaling pathway_Homo sapiens_hsa040710.49871101
134HIF-1 signaling pathway_Homo sapiens_hsa040660.48650597
135Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.48294231
136Proteoglycans in cancer_Homo sapiens_hsa052050.47595409
137Pancreatic secretion_Homo sapiens_hsa049720.46133697
138RNA degradation_Homo sapiens_hsa030180.45314315
139Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.44784972
140Focal adhesion_Homo sapiens_hsa045100.44414272
141Regulation of actin cytoskeleton_Homo sapiens_hsa048100.43886194
142Inositol phosphate metabolism_Homo sapiens_hsa005620.43846355
143Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.42564705
144Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.41357931
145Huntingtons disease_Homo sapiens_hsa050160.40160130
146FoxO signaling pathway_Homo sapiens_hsa040680.38552847
147Longevity regulating pathway - mammal_Homo sapiens_hsa042110.38448091
148Fatty acid metabolism_Homo sapiens_hsa012120.37313773
149Parkinsons disease_Homo sapiens_hsa050120.36612564
150Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.35395219
151Metabolic pathways_Homo sapiens_hsa011000.33551969
152Ether lipid metabolism_Homo sapiens_hsa005650.32894968
153Pentose and glucuronate interconversions_Homo sapiens_hsa000400.28896534
154beta-Alanine metabolism_Homo sapiens_hsa004100.28463501
155Nitrogen metabolism_Homo sapiens_hsa009100.27254876
156Folate biosynthesis_Homo sapiens_hsa007900.27126246
157Peroxisome_Homo sapiens_hsa041460.24677750
158Arginine and proline metabolism_Homo sapiens_hsa003300.23985716
159Glutathione metabolism_Homo sapiens_hsa004800.20507973

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