SLC39A11

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1intestinal cholesterol absorption (GO:0030299)4.88807526
2antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)4.46906003
3antigen processing and presentation of endogenous peptide antigen (GO:0002483)4.46906003
4protein retention in ER lumen (GO:0006621)4.35642013
5cysteine metabolic process (GO:0006534)4.29912221
6sulfur amino acid catabolic process (GO:0000098)4.28188804
7maintenance of protein localization in endoplasmic reticulum (GO:0035437)4.28147033
8L-phenylalanine metabolic process (GO:0006558)3.98914440
9erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)3.98914440
10respiratory chain complex IV assembly (GO:0008535)3.88510447
11L-phenylalanine catabolic process (GO:0006559)3.83510582
12erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)3.83510582
13xenobiotic catabolic process (GO:0042178)3.83185416
14valine metabolic process (GO:0006573)3.78929337
15cytochrome complex assembly (GO:0017004)3.77442324
16Golgi transport vesicle coating (GO:0048200)3.77142711
17COPI coating of Golgi vesicle (GO:0048205)3.77142711
18keratinocyte development (GO:0003334)3.74062428
19antigen processing and presentation of endogenous antigen (GO:0019883)3.70753245
20disruption of cells of other organism involved in symbiotic interaction (GO:0051818)3.67485918
21killing of cells in other organism involved in symbiotic interaction (GO:0051883)3.67485918
22proteasome assembly (GO:0043248)3.66112208
23oligosaccharide catabolic process (GO:0009313)3.63425030
24serine family amino acid biosynthetic process (GO:0009070)3.62412974
25pentose-phosphate shunt (GO:0006098)3.59531123
26platelet dense granule organization (GO:0060155)3.52165263
27exocrine pancreas development (GO:0031017)3.50278574
28glycine metabolic process (GO:0006544)3.44436445
29alpha-linolenic acid metabolic process (GO:0036109)3.44156874
30keratan sulfate catabolic process (GO:0042340)3.43883646
31proline biosynthetic process (GO:0006561)3.43364659
32NADPH regeneration (GO:0006740)3.41154912
33positive regulation of glycoprotein biosynthetic process (GO:0010560)3.38613111
34lactate metabolic process (GO:0006089)3.38215709
35glutathione derivative biosynthetic process (GO:1901687)3.36296823
36glutathione derivative metabolic process (GO:1901685)3.36296823
37aromatic amino acid family catabolic process (GO:0009074)3.35984886
38antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G3.35152109
39cellular modified amino acid catabolic process (GO:0042219)3.34317550
40glyoxylate metabolic process (GO:0046487)3.29831324
41serine family amino acid metabolic process (GO:0009069)3.27335355
42intestinal absorption (GO:0050892)3.22626460
43triglyceride-rich lipoprotein particle remodeling (GO:0034370)3.21918359
44digestion (GO:0007586)3.20130039
45negative regulation of inflammatory response to antigenic stimulus (GO:0002862)3.18892374
46killing of cells of other organism (GO:0031640)3.18587179
47disruption of cells of other organism (GO:0044364)3.18587179
48fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)3.18419845
49lysine catabolic process (GO:0006554)3.16009732
50lysine metabolic process (GO:0006553)3.16009732
51antigen processing and presentation via MHC class Ib (GO:0002475)3.15354603
52positive regulation of glycoprotein metabolic process (GO:1903020)3.13564024
53transcytosis (GO:0045056)3.08745551
54L-serine metabolic process (GO:0006563)3.08298187
55UDP-N-acetylglucosamine metabolic process (GO:0006047)3.05395289
56glycosphingolipid catabolic process (GO:0046479)3.04748281
57homocysteine metabolic process (GO:0050667)3.00998205
58positive regulation of interleukin-8 biosynthetic process (GO:0045416)2.97950306
59kynurenine metabolic process (GO:0070189)2.97817941
60indolalkylamine catabolic process (GO:0046218)2.96688805
61tryptophan catabolic process (GO:0006569)2.96688805
62indole-containing compound catabolic process (GO:0042436)2.96688805
63retinal metabolic process (GO:0042574)2.94262751
64water-soluble vitamin biosynthetic process (GO:0042364)2.92382072
65urea cycle (GO:0000050)2.90473306
66urea metabolic process (GO:0019627)2.90473306
67ethanol oxidation (GO:0006069)2.89947986
68peptidyl-glutamic acid carboxylation (GO:0017187)2.88153145
69protein carboxylation (GO:0018214)2.88153145
70cell wall macromolecule catabolic process (GO:0016998)2.87865679
71tryptophan metabolic process (GO:0006568)2.86817583
72mitochondrial calcium ion transport (GO:0006851)2.85985855
73serine family amino acid catabolic process (GO:0009071)2.83567725
74primary alcohol catabolic process (GO:0034310)2.81881574
75ceramide catabolic process (GO:0046514)2.81784740
764-hydroxyproline metabolic process (GO:0019471)2.81070300
77bile acid biosynthetic process (GO:0006699)2.80714749
78amino-acid betaine metabolic process (GO:0006577)2.80036433
79Arp2/3 complex-mediated actin nucleation (GO:0034314)2.79640734
80proline metabolic process (GO:0006560)2.79007480
81regulation of protein glycosylation (GO:0060049)2.78865994
82sphingolipid catabolic process (GO:0030149)2.77640832
83positive regulation of protein autophosphorylation (GO:0031954)2.77455090
84intracellular pH reduction (GO:0051452)2.77399016
85regulation of calcineurin-NFAT signaling cascade (GO:0070884)2.76130763
86regulation of B cell apoptotic process (GO:0002902)2.75264891
87bile acid and bile salt transport (GO:0015721)2.73722459
88neutrophil activation involved in immune response (GO:0002283)2.73541019
89glycolipid catabolic process (GO:0019377)2.72719015
90membrane lipid catabolic process (GO:0046466)2.72362014
91regulation of cellular amino acid metabolic process (GO:0006521)2.71534028
92nitrogen cycle metabolic process (GO:0071941)2.71371148
93negative regulation of sterol transport (GO:0032372)2.70837189
94negative regulation of cholesterol transport (GO:0032375)2.70837189
95glucosamine-containing compound catabolic process (GO:1901072)2.70735823
96cellular ketone body metabolic process (GO:0046950)2.70193869
97negative regulation of complement activation (GO:0045916)2.69674949
98negative regulation of fibrinolysis (GO:0051918)2.68813690
99response to hydroperoxide (GO:0033194)2.68456200
100signal peptide processing (GO:0006465)2.65986309
101branched-chain amino acid metabolic process (GO:0009081)2.65725090
102high-density lipoprotein particle remodeling (GO:0034375)2.65164833
103pteridine-containing compound biosynthetic process (GO:0042559)2.64810245
104mannosylation (GO:0097502)2.63764283
105C-terminal protein lipidation (GO:0006501)2.63531712
106nucleotide salvage (GO:0043173)2.63025478
107nucleoside salvage (GO:0043174)2.60890416
108S-adenosylmethionine metabolic process (GO:0046500)2.59635216
109branched-chain amino acid catabolic process (GO:0009083)2.58480057
1102-oxoglutarate metabolic process (GO:0006103)2.58186103
111peptide catabolic process (GO:0043171)2.57900716
112sphingoid metabolic process (GO:0046519)2.56785639
113ethanol metabolic process (GO:0006067)2.56007629
114positive regulation of B cell differentiation (GO:0045579)2.55851542
115cellular amino acid catabolic process (GO:0009063)2.55823070
116regulation of triglyceride catabolic process (GO:0010896)2.54783053
117pyrimidine-containing compound transmembrane transport (GO:0072531)2.54400527
118folic acid-containing compound biosynthetic process (GO:0009396)2.53832327
119galactose catabolic process (GO:0019388)2.53657162
120negative regulation of protein activation cascade (GO:2000258)2.52732032
121neutrophil mediated immunity (GO:0002446)2.52722544
122positive regulation of prostaglandin secretion (GO:0032308)2.51722124
123defense response to fungus (GO:0050832)2.51416815
124NADP metabolic process (GO:0006739)2.50871427
125complement activation, alternative pathway (GO:0006957)2.50549129
126protein-lipid complex remodeling (GO:0034368)2.50011662
127macromolecular complex remodeling (GO:0034367)2.50011662
128plasma lipoprotein particle remodeling (GO:0034369)2.50011662
129response to nitrosative stress (GO:0051409)2.49892426
130regulation of cholesterol homeostasis (GO:2000188)2.49309834
131DNA deamination (GO:0045006)2.49035411
132alpha-amino acid catabolic process (GO:1901606)2.48460293
133aromatic amino acid family metabolic process (GO:0009072)2.47129689
134ribosomal small subunit assembly (GO:0000028)2.47042582
135dolichol-linked oligosaccharide biosynthetic process (GO:0006488)2.45804084
136reverse cholesterol transport (GO:0043691)2.45703099
137pH reduction (GO:0045851)2.45667488
138regulation of protein activation cascade (GO:2000257)2.45034575
139bile acid metabolic process (GO:0008206)2.44964551
140one-carbon metabolic process (GO:0006730)2.44825928
141phospholipid efflux (GO:0033700)2.44821691
142DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:002.44801034
143drug transmembrane transport (GO:0006855)2.43892684
144hexose catabolic process (GO:0019320)2.43600140
145diol metabolic process (GO:0034311)2.43511764
146sphingosine metabolic process (GO:0006670)2.43063690
147positive regulation of heterotypic cell-cell adhesion (GO:0034116)2.42960680
148ketone body metabolic process (GO:1902224)2.42107254
149regulation of metalloenzyme activity (GO:0048552)2.41247238
150vitamin biosynthetic process (GO:0009110)2.40670238
151retinol metabolic process (GO:0042572)2.39367953
152amine catabolic process (GO:0009310)2.39098562
153cellular biogenic amine catabolic process (GO:0042402)2.39098562
154prostate gland growth (GO:0060736)2.37401147
155signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)2.37152234
156signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)2.37152234
157signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)2.37152234
158L-ascorbic acid metabolic process (GO:0019852)2.35901221
159regulation of intracellular pH (GO:0051453)2.35550544
160transepithelial transport (GO:0070633)2.35400625
161intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)2.35229774
162signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)2.35229774
163negative regulation of protein autophosphorylation (GO:0031953)2.35135988
164iron ion import (GO:0097286)2.33911935
165regulation of hexokinase activity (GO:1903299)2.33611205
166regulation of glucokinase activity (GO:0033131)2.33611205
167diterpenoid biosynthetic process (GO:0016102)2.30411598
168indolalkylamine metabolic process (GO:0006586)2.30246334
169antigen processing and presentation of peptide antigen via MHC class I (GO:0002474)2.28542967
170lytic vacuole organization (GO:0080171)2.27787907
171lysosome organization (GO:0007040)2.27787907
172ER overload response (GO:0006983)2.27776335
173C-terminal protein amino acid modification (GO:0018410)2.27564449
174regulation of cellular pH (GO:0030641)2.27505712
175sphingomyelin metabolic process (GO:0006684)2.27319024
176cell wall macromolecule metabolic process (GO:0044036)2.25376110
177nonribosomal peptide biosynthetic process (GO:0019184)2.23528449
178glutathione biosynthetic process (GO:0006750)2.23365125
179short-chain fatty acid metabolic process (GO:0046459)2.23016408
180response to interferon-beta (GO:0035456)2.22446588
181terpenoid biosynthetic process (GO:0016114)2.21850310
182protein K6-linked ubiquitination (GO:0085020)2.21163220
183aldehyde catabolic process (GO:0046185)2.20453368

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1ESR1_17901129_ChIP-ChIP_LIVER_Mouse5.00719996
2RXR_22158963_ChIP-Seq_LIVER_Mouse3.45856203
3PPARA_22158963_ChIP-Seq_LIVER_Mouse3.33011228
4IRF8_22096565_ChIP-ChIP_GC-B_Human3.24155884
5PPARG_19300518_ChIP-PET_3T3-L1_Mouse3.03347190
6EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.85872825
7KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.74315699
8CEBPA_23403033_ChIP-Seq_LIVER_Mouse2.60539922
9ESR1_21235772_ChIP-Seq_MCF-7_Human2.42913089
10EGR1_23403033_ChIP-Seq_LIVER_Mouse2.39540683
11LXR_22158963_ChIP-Seq_LIVER_Mouse2.35161418
12GABP_17652178_ChIP-ChIP_JURKAT_Human2.19765015
13NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human2.18510020
14CEBPB_23403033_ChIP-Seq_LIVER_Mouse2.17146232
15MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.10322287
16ELF1_17652178_ChIP-ChIP_JURKAT_Human2.09003860
17RUNX1_20887958_ChIP-Seq_HPC-7_Mouse2.05041105
18ELK1_19687146_ChIP-ChIP_HELA_Human2.01290829
19ESR1_20079471_ChIP-ChIP_T-47D_Human2.01023220
20E2F7_22180533_ChIP-Seq_HELA_Human1.99428787
21FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.96408396
22MYB_21317192_ChIP-Seq_ERMYB_Mouse1.95723655
23IRF8_21731497_ChIP-ChIP_J774_Mouse1.94859748
24VDR_21846776_ChIP-Seq_THP-1_Human1.91585726
25* SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.87789044
26MYC_22102868_ChIP-Seq_BL_Human1.85048616
27SCL_19346495_ChIP-Seq_HPC-7_Human1.83979404
28IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.83139767
29Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.82468083
30SRF_21415370_ChIP-Seq_HL-1_Mouse1.76006230
31MYC_18555785_ChIP-Seq_MESCs_Mouse1.75278087
32FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.72480067
33FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.71002583
34SOX2_20726797_ChIP-Seq_SW620_Human1.69391751
35BRD4_27068464_Chip-Seq_AML-cells_Mouse1.66878104
36STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.64826191
37NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.63493302
38TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.62697125
39VDR_22108803_ChIP-Seq_LS180_Human1.60453488
40SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.59337494
41IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.57672970
42* ZNF217_24962896_ChIP-Seq_MCF-7_Human1.57296041
43SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.54631627
44HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.54299130
45EST1_17652178_ChIP-ChIP_JURKAT_Human1.53914938
46TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.51951374
47SMAD_19615063_ChIP-ChIP_OVARY_Human1.51770125
48FOXM1_26456572_ChIP-Seq_MCF-7_Human1.50199061
49ELF5_23300383_ChIP-Seq_T47D_Human1.48798182
50NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.47566423
51ER_23166858_ChIP-Seq_MCF-7_Human1.47319925
52EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.47005194
53* CDX2_22108803_ChIP-Seq_LS180_Human1.46324606
54* SPI1_23547873_ChIP-Seq_NB4_Human1.45863187
55VDR_24763502_ChIP-Seq_THP-1_Human1.45850579
56SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.45675031
57GATA1_22025678_ChIP-Seq_K562_Human1.45448392
58ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.44438015
59GATA1_22383799_ChIP-Seq_G1ME_Mouse1.44060601
60EGR1_19374776_ChIP-ChIP_THP-1_Human1.43857621
61SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.43754002
62AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.42717330
63RUNX1_22412390_ChIP-Seq_EML_Mouse1.40918933
64E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.39997806
65IRF8_27001747_Chip-Seq_BMDM_Mouse1.39847989
66TP63_17297297_ChIP-ChIP_HaCaT_Human1.39560578
67MYC_18358816_ChIP-ChIP_MESCs_Mouse1.38802032
68FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human1.38155446
69GATA3_24758297_ChIP-Seq_MCF-7_Human1.35798201
70LXR_22292898_ChIP-Seq_THP-1_Human1.35607337
71* PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.35306391
72ERG_20887958_ChIP-Seq_HPC-7_Mouse1.35221744
73POU3F2_20337985_ChIP-ChIP_501MEL_Human1.34815911
74TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.34464919
75SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.33033735
76ZNF274_21170338_ChIP-Seq_K562_Hela1.32782646
77GATA3_26560356_Chip-Seq_TH2_Human1.29638838
78CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.27407833
79FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human1.27253720
80PADI4_21655091_ChIP-ChIP_MCF-7_Human1.27172267
81VDR_23849224_ChIP-Seq_CD4+_Human1.26393833
82AR_21915096_ChIP-Seq_LNCaP-1F5_Human1.25398357
83TFEB_21752829_ChIP-Seq_HELA_Human1.24941191
84STAT3_1855785_ChIP-Seq_MESCs_Mouse1.23055233
85CDX2_19796622_ChIP-Seq_MESCs_Mouse1.22972823
86MAF_26560356_Chip-Seq_TH1_Human1.22891965
87CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.22585380
88AR_20517297_ChIP-Seq_VCAP_Human1.22381179
89SOX2_19829295_ChIP-Seq_ESCs_Human1.21865553
90NANOG_19829295_ChIP-Seq_ESCs_Human1.21865553
91GATA2_22383799_ChIP-Seq_G1ME_Mouse1.21098696
92HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.20111918
93FOXA1_27270436_Chip-Seq_PROSTATE_Human1.20084033
94FOXA1_25329375_ChIP-Seq_VCAP_Human1.20084033
95SOX2_27498859_Chip-Seq_STOMACH_Mouse1.20037160
96LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.19645045
97ELK3_25401928_ChIP-Seq_HUVEC_Human1.19336632
98CJUN_26792858_Chip-Seq_BT549_Human1.19236607
99NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.18934497
100FOXA1_21572438_ChIP-Seq_LNCaP_Human1.18463753
101MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.18239105
102GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.18071453
103STAT4_19710469_ChIP-ChIP_TH1__Mouse1.17852590
104MYB_26560356_Chip-Seq_TH2_Human1.13834556
105EZH2_27294783_Chip-Seq_NPCs_Mouse1.13590777
106FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.13285357
107VDR_24787735_ChIP-Seq_THP-1_Human1.12393417
108TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.11825516
109FLI1_27457419_Chip-Seq_LIVER_Mouse1.11366559
110NRF2_20460467_ChIP-Seq_MEFs_Mouse1.10908088
111NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.10908088
112EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.09841042
113* ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.09383592
114CLOCK_20551151_ChIP-Seq_293T_Human1.08755531
115FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.08696125
116CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.08300067
117CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.08109258
118PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.07809266
119JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.07530777
120ZFP57_27257070_Chip-Seq_ESCs_Mouse1.07122214
121SUZ12_27294783_Chip-Seq_NPCs_Mouse1.07073026
122* UTX_26944678_Chip-Seq_JUKART_Human1.06733990
123* CRX_20693478_ChIP-Seq_RETINA_Mouse1.06687223
124NFE2_27457419_Chip-Seq_LIVER_Mouse1.06555029
125CBP_20019798_ChIP-Seq_JUKART_Human1.06377727
126IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.06377727
127STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.05385003
128RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.04919525
129MYB_26560356_Chip-Seq_TH1_Human1.04886884
130BCOR_27268052_Chip-Seq_Bcells_Human1.04436174
131ZFX_18555785_ChIP-Seq_MESCs_Mouse1.03743407
132FOXA1_26743006_Chip-Seq_LNCaP-abl_Human1.03480300
133SALL1_21062744_ChIP-ChIP_HESCs_Human1.03239536
134RARG_19884340_ChIP-ChIP_MEFs_Mouse1.02887022
135TCF7_22412390_ChIP-Seq_EML_Mouse1.02810437
136GFI1B_20887958_ChIP-Seq_HPC-7_Mouse1.02106800
137XRN2_22483619_ChIP-Seq_HELA_Human1.01669563
138GATA4_25053715_ChIP-Seq_YYC3_Human1.01620325
139* P300_19829295_ChIP-Seq_ESCs_Human1.00793203
140PCGF2_27294783_Chip-Seq_ESCs_Mouse0.99838320
141E2F1_18555785_ChIP-Seq_MESCs_Mouse0.99481776
142* AHR_22903824_ChIP-Seq_MCF-7_Human0.99416341
143BCL6_27268052_Chip-Seq_Bcells_Human0.99244257
144FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse0.98604955
145HOXB4_20404135_ChIP-ChIP_EML_Mouse0.98548473
146CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse0.98447672
147* BCAT_22108803_ChIP-Seq_LS180_Human0.97799306
148ETS1_20019798_ChIP-Seq_JURKAT_Human0.97510125
149GABP_19822575_ChIP-Seq_HepG2_Human0.97504823
150PPAR_26484153_Chip-Seq_NCI-H1993_Human0.97439390
151CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse0.95058777
152LYL1_20887958_ChIP-Seq_HPC-7_Mouse0.94533020
153TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse0.93838059
154RACK7_27058665_Chip-Seq_MCF-7_Human0.93793960
155GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.93738715
156POU5F1_18700969_ChIP-ChIP_MESCs_Mouse0.93685262
157* CDX2_20551321_ChIP-Seq_CACO-2_Human0.93533511
158HOXB7_26014856_ChIP-Seq_BT474_Human0.93489393
159* CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse0.93417394
160NR1I2_20693526_ChIP-Seq_LIVER_Mouse0.93208088
161TP63_23658742_ChIP-Seq_EP156T_Human0.92767877
162MYC_19030024_ChIP-ChIP_MESCs_Mouse0.92661338
163GATA6_25053715_ChIP-Seq_YYC3_Human0.92029745
164* TCF7L2_21901280_ChIP-Seq_H4IIE_Rat0.91828971
165GATA1_19941827_ChIP-Seq_MEL_Mouse0.91729834
166KDM2B_26808549_Chip-Seq_SIL-ALL_Human0.90757006
167TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat0.90079515
168* PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse0.89990834
169DCP1A_22483619_ChIP-Seq_HELA_Human0.89813661
170PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.89075314
171STAT6_20620947_ChIP-Seq_CD4_POS_T_Human0.89045361
172ESR1_15608294_ChIP-ChIP_MCF-7_Human0.88847819

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005365_abnormal_bile_salt4.33379847
2MP0002139_abnormal_hepatobiliary_system4.24904421
3MP0005360_urolithiasis4.12422256
4MP0001666_abnormal_nutrient_absorption3.92111542
5MP0005083_abnormal_biliary_tract3.54632049
6MP0005085_abnormal_gallbladder_physiolo3.43459952
7MP0003806_abnormal_nucleotide_metabolis2.71772164
8MP0008875_abnormal_xenobiotic_pharmacok2.49934664
9MP0009840_abnormal_foam_cell2.43526083
10MP0005220_abnormal_exocrine_pancreas2.27307207
11MP0005058_abnormal_lysosome_morphology2.24279028
12MP0010234_abnormal_vibrissa_follicle2.22009124
13MP0003191_abnormal_cellular_cholesterol2.18176517
14MP0001835_abnormal_antigen_presentation2.12702449
15MP0003436_decreased_susceptibility_to2.06851805
16MP0002876_abnormal_thyroid_physiology2.06843061
17MP0003868_abnormal_feces_composition1.99676872
18MP0010329_abnormal_lipoprotein_level1.97776201
19MP0010386_abnormal_urinary_bladder1.97109942
20MP0005408_hypopigmentation1.96706927
21MP0009780_abnormal_chondrocyte_physiolo1.95884836
22MP0003252_abnormal_bile_duct1.94526029
23MP0000372_irregular_coat_pigmentation1.84851853
24MP0001873_stomach_inflammation1.81479925
25MP0005075_abnormal_melanosome_morpholog1.81362160
26MP0009785_altered_susceptibility_to1.74992495
27MP0005332_abnormal_amino_acid1.73513646
28MP0000427_abnormal_hair_cycle1.70647518
29MP0000685_abnormal_immune_system1.67953521
30MP0002090_abnormal_vision1.67217305
31MP0003705_abnormal_hypodermis_morpholog1.64598321
32MP0005646_abnormal_pituitary_gland1.62220797
33MP0005464_abnormal_platelet_physiology1.60795288
34MP0000490_abnormal_crypts_of1.56557956
35MP0000609_abnormal_liver_physiology1.54386702
36MP0002396_abnormal_hematopoietic_system1.52728352
37MP0002837_dystrophic_cardiac_calcinosis1.50993457
38MP0005084_abnormal_gallbladder_morpholo1.50828098
39MP0003656_abnormal_erythrocyte_physiolo1.49255890
40MP0005025_abnormal_response_to1.48620216
41MP0003186_abnormal_redox_activity1.48047894
42MP0005379_endocrine/exocrine_gland_phen1.46574910
43MP0005319_abnormal_enzyme/_coenzyme1.45519670
44MP0010678_abnormal_skin_adnexa1.44702485
45MP0009643_abnormal_urine_homeostasis1.44009055
46MP0009697_abnormal_copulation1.40642362
47MP0010155_abnormal_intestine_physiology1.40394074
48MP0008469_abnormal_protein_level1.39918273
49MP0008004_abnormal_stomach_pH1.39875935
50MP0004264_abnormal_extraembryonic_tissu1.39707691
51MP0003300_gastrointestinal_ulcer1.38953453
52MP0002166_altered_tumor_susceptibility1.38353420
53MP0002419_abnormal_innate_immunity1.38336541
54MP0003172_abnormal_lysosome_physiology1.37185444
55MP0002118_abnormal_lipid_homeostasis1.33925571
56MP0003303_peritoneal_inflammation1.33723786
57MP0001845_abnormal_inflammatory_respons1.31283527
58MP0003950_abnormal_plasma_membrane1.29917904
59MP0001756_abnormal_urination1.28970841
60MP0010352_gastrointestinal_tract_polyps1.27718872
61MP0004019_abnormal_vitamin_homeostasis1.27575423
62MP0004381_abnormal_hair_follicle1.26903472
63MP0006054_spinal_hemorrhage1.25363186
64MP0006036_abnormal_mitochondrial_physio1.24734094
65MP0004147_increased_porphyrin_level1.22410473
66MP0003724_increased_susceptibility_to1.21889516
67MP0003786_premature_aging1.21752771
68MP0000015_abnormal_ear_pigmentation1.20949485
69MP0006082_CNS_inflammation1.20791551
70MP0003183_abnormal_peptide_metabolism1.19307147
71MP0004947_skin_inflammation1.17412003
72MP0000598_abnormal_liver_morphology1.17157111
73MP0005671_abnormal_response_to1.13197794
74MP0001764_abnormal_homeostasis1.12493610
75MP0005310_abnormal_salivary_gland1.11664477
76MP0000465_gastrointestinal_hemorrhage1.11226765
77MP0000371_diluted_coat_color1.11142046
78MP0005000_abnormal_immune_tolerance1.10940968
79MP0003866_abnormal_defecation1.09293717
80MP0004883_abnormal_blood_vessel1.09230211
81MP0002452_abnormal_antigen_presenting1.08579383
82MP0002723_abnormal_immune_serum1.08245857
83MP0001800_abnormal_humoral_immune1.08220526
84MP0005584_abnormal_enzyme/coenzyme_acti1.08157504
85MP0003075_altered_response_to1.07987793
86MP0000569_abnormal_digit_pigmentation1.07407612
87MP0001663_abnormal_digestive_system1.06993257
88MP0010307_abnormal_tumor_latency1.06026561
89MP0005367_renal/urinary_system_phenotyp1.05654068
90MP0000516_abnormal_urinary_system1.05654068
91MP0008872_abnormal_physiological_respon1.04789749
92MP0002420_abnormal_adaptive_immunity1.04741891
93MP0005397_hematopoietic_system_phenotyp1.04137840
94MP0001545_abnormal_hematopoietic_system1.04137840
95MP0005410_abnormal_fertilization1.03953619
96MP0005636_abnormal_mineral_homeostasis1.03560241
97MP0001819_abnormal_immune_cell1.03028645
98MP0003763_abnormal_thymus_physiology1.02803950
99MP0002405_respiratory_system_inflammati1.02623100
100MP0005451_abnormal_body_composition1.01844456
101MP0001853_heart_inflammation1.01554158
102MP0005164_abnormal_response_to1.00760199
103MP0008995_early_reproductive_senescence1.00170726
104MP0000689_abnormal_spleen_morphology0.99617636
105MP0000858_altered_metastatic_potential0.97778567
106MP0001533_abnormal_skeleton_physiology0.96846083
107MP0002148_abnormal_hypersensitivity_rea0.95178275
108MP0005165_increased_susceptibility_to0.93451566
109MP0003638_abnormal_response/metabolism_0.93411418
110MP0003693_abnormal_embryo_hatching0.92201355
111MP0000613_abnormal_salivary_gland0.90651091
112MP0001881_abnormal_mammary_gland0.90330592
113MP0002398_abnormal_bone_marrow0.89682959
114MP0000604_amyloidosis0.89575968
115MP0005647_abnormal_sex_gland0.89293316
116MP0009763_increased_sensitivity_to0.88578571
117MP0002006_tumorigenesis0.87913542
118MP0005387_immune_system_phenotype0.87690335
119MP0001790_abnormal_immune_system0.87690335
120MP0000538_abnormal_urinary_bladder0.87466289
121MP0002138_abnormal_hepatobiliary_system0.86603365
122MP0001664_abnormal_digestion0.86443727
123MP0009333_abnormal_splenocyte_physiolog0.86363944
124MP0000716_abnormal_immune_system0.85837768
125MP0002277_abnormal_respiratory_mucosa0.85790101
126MP0005166_decreased_susceptibility_to0.85751815
127MP0003195_calcinosis0.85431182
128MP0005174_abnormal_tail_pigmentation0.84796083
129MP0009764_decreased_sensitivity_to0.84732735
130MP0002722_abnormal_immune_system0.84593377
131MP0000477_abnormal_intestine_morphology0.84547287
132MP0002429_abnormal_blood_cell0.83196200
133MP0000383_abnormal_hair_follicle0.81868515
134MP0009642_abnormal_blood_homeostasis0.81096199
135MP0004808_abnormal_hematopoietic_stem0.80942650
136MP0002132_abnormal_respiratory_system0.80309864
137MP0001986_abnormal_taste_sensitivity0.80112800
138MP0002693_abnormal_pancreas_physiology0.79144041
139MP0000343_altered_response_to0.78157319
140MP0003959_abnormal_lean_body0.77837079
141MP0003566_abnormal_cell_adhesion0.77817156
142MP0002254_reproductive_system_inflammat0.77420138
143MP0002168_other_aberrant_phenotype0.76824917

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of glycolipid metabolism (HP:0010969)4.79920045
2Abnormality of liposaccharide metabolism (HP:0010968)4.79920045
3Abnormality of glycosphingolipid metabolism (HP:0004343)4.79920045
4Abnormality of aromatic amino acid family metabolism (HP:0004338)4.67672511
5Vacuolated lymphocytes (HP:0001922)3.93193291
6Abnormality of monocarboxylic acid metabolism (HP:0010996)3.57797433
7Intrahepatic cholestasis (HP:0001406)3.41534285
8Fat malabsorption (HP:0002630)3.37774521
9Xanthomatosis (HP:0000991)3.34042190
10Abnormality of the intrinsic pathway (HP:0010989)3.32025594
11Hypobetalipoproteinemia (HP:0003563)3.18511321
12Tongue fasciculations (HP:0001308)3.16321726
13Deep venous thrombosis (HP:0002625)3.16071878
14Steatorrhea (HP:0002570)3.10843428
15Dysostosis multiplex (HP:0000943)3.04816301
16Prostate neoplasm (HP:0100787)2.99100860
17Abnormality of the common coagulation pathway (HP:0010990)2.97643379
18Thrombocytosis (HP:0001894)2.96425268
19Ketosis (HP:0001946)2.93426104
20Reduced antithrombin III activity (HP:0001976)2.90907982
21Albinism (HP:0001022)2.90382339
22Hypoglycemic coma (HP:0001325)2.89223080
23Urinary glycosaminoglycan excretion (HP:0003541)2.86351695
24Mucopolysacchariduria (HP:0008155)2.86351695
25Loss of speech (HP:0002371)2.81761859
26Recurrent gram-negative bacterial infections (HP:0005420)2.80515063
27Hyperammonemia (HP:0001987)2.79735766
28Hypothermia (HP:0002045)2.75873469
29Muscle fibrillation (HP:0010546)2.65030544
30Abnormality of polysaccharide metabolism (HP:0011012)2.61324429
31Abnormality of glycosaminoglycan metabolism (HP:0004371)2.61324429
32Abnormality of mucopolysaccharide metabolism (HP:0011020)2.61324429
33Hyperlipoproteinemia (HP:0010980)2.60663813
34Hyperglycinuria (HP:0003108)2.59981348
35Prolonged partial thromboplastin time (HP:0003645)2.59233996
36Abnormal cartilage morphology (HP:0002763)2.56847995
37Abnormality of sulfur amino acid metabolism (HP:0004339)2.55475221
38Abnormality of long-chain fatty-acid metabolism (HP:0010964)2.55188267
39Complement deficiency (HP:0004431)2.53811248
40Abnormality of fatty-acid metabolism (HP:0004359)2.51351193
41Late onset (HP:0003584)2.48719400
42Elevated erythrocyte sedimentation rate (HP:0003565)2.46757137
43Ketoacidosis (HP:0001993)2.46341739
44Hyperglycinemia (HP:0002154)2.45422276
45Abnormality of glutamine family amino acid metabolism (HP:0010902)2.45396057
46Recurrent bacterial skin infections (HP:0005406)2.44047922
47Joint hemorrhage (HP:0005261)2.43669712
48Eczematoid dermatitis (HP:0000976)2.41304692
49Beaking of vertebral bodies (HP:0004568)2.40402908
50Hypokinesia (HP:0002375)2.38632296
51Recurrent abscess formation (HP:0002722)2.36190578
52Increased CSF protein (HP:0002922)2.34459506
53Dicarboxylic aciduria (HP:0003215)2.34221822
54Abnormality of dicarboxylic acid metabolism (HP:0010995)2.34221822
55Abnormality of glycine metabolism (HP:0010895)2.32537870
56Abnormality of serine family amino acid metabolism (HP:0010894)2.32537870
57Posterior subcapsular cataract (HP:0007787)2.30881577
58Generalized aminoaciduria (HP:0002909)2.30165480
59Increased cerebral lipofuscin (HP:0011813)2.29384108
60Thoracic kyphosis (HP:0002942)2.28560195
61Gout (HP:0001997)2.28045376
62Abnormality of dental color (HP:0011073)2.26803019
63IgM deficiency (HP:0002850)2.26741519
64Chronic otitis media (HP:0000389)2.26404122
65Abnormality of the thoracic spine (HP:0100711)2.26367356
66Pancreatitis (HP:0001733)2.26227030
67Abnormality of complement system (HP:0005339)2.25380930
68Type I transferrin isoform profile (HP:0003642)2.21389770
69Flat acetabular roof (HP:0003180)2.21223343
70Hepatic necrosis (HP:0002605)2.19977273
71Myocardial infarction (HP:0001658)2.19963899
72Systemic lupus erythematosus (HP:0002725)2.18497040
73Petechiae (HP:0000967)2.17998165
74Cutaneous melanoma (HP:0012056)2.16783618
75Disinhibition (HP:0000734)2.15958085
76Hypolipoproteinemia (HP:0010981)2.15158000
77Epistaxis (HP:0000421)2.14884877
78Progressive macrocephaly (HP:0004481)2.13852465
79Abnormality of the prostate (HP:0008775)2.13773677
80Spastic diplegia (HP:0001264)2.13467106
81Increased CSF lactate (HP:0002490)2.11748306
82Hematochezia (HP:0002573)2.11427064
83Increased neuronal autofluorescent lipopigment (HP:0002074)2.11239158
84Pustule (HP:0200039)2.11132728
85Methylmalonic aciduria (HP:0012120)2.10822820
86Progressive neurologic deterioration (HP:0002344)2.10540421
87Acute encephalopathy (HP:0006846)2.08353612
88Hyperbilirubinemia (HP:0002904)2.07763057
89Abnormality of the level of lipoprotein cholesterol (HP:0010979)2.06490708
90Mutism (HP:0002300)2.06417570
91Urticaria (HP:0001025)2.05398068
92Abnormality of T cell physiology (HP:0011840)2.04913795
93Abnormality of aspartate family amino acid metabolism (HP:0010899)2.04722594
94Abnormal platelet function (HP:0011869)2.04672183
95Impaired platelet aggregation (HP:0003540)2.04672183
96Mitochondrial inheritance (HP:0001427)2.04551401
97Disproportionate short-trunk short stature (HP:0003521)2.03398766
98Abnormal tarsal ossification (HP:0008369)2.02655167
99Abnormality of purine metabolism (HP:0004352)2.02613839
100Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)2.02177946
101Breast carcinoma (HP:0003002)2.01425668
102Joint stiffness (HP:0001387)2.00404953
103Malnutrition (HP:0004395)2.00324839
104Hepatocellular necrosis (HP:0001404)1.99540757
105Abdominal distention (HP:0003270)1.98665520
106Abnormal isoelectric focusing of serum transferrin (HP:0003160)1.98620601
107Abnormal protein N-linked glycosylation (HP:0012347)1.98620601
108Abnormal protein glycosylation (HP:0012346)1.98620601
109Abnormal glycosylation (HP:0012345)1.98620601
110Periodontitis (HP:0000704)1.97892733
111Abnormality of nucleobase metabolism (HP:0010932)1.97559938
112Respiratory failure (HP:0002878)1.96998691
113Gingival bleeding (HP:0000225)1.96100603
114Acute necrotizing encephalopathy (HP:0006965)1.95270352
115Hypoplasia of the odontoid process (HP:0003311)1.94833974
116Cardiomegaly (HP:0001640)1.94096224
117Symptomatic seizures (HP:0011145)1.92045511
118Pancreatic cysts (HP:0001737)1.92040002
119Conjugated hyperbilirubinemia (HP:0002908)1.91936213
120Hydroxyprolinuria (HP:0003080)1.91664729
121Abnormality of proline metabolism (HP:0010907)1.91664729
122Hypoglycemic seizures (HP:0002173)1.91612043
123Myositis (HP:0100614)1.90624646
124Menorrhagia (HP:0000132)1.90448940
125Glomerulonephritis (HP:0000099)1.89674053
126Opisthotonus (HP:0002179)1.89604024
127Epidermoid cyst (HP:0200040)1.89444921
128Pancreatic islet-cell hyperplasia (HP:0004510)1.89277500
129Hypercholesterolemia (HP:0003124)1.88781170
130Abnormality of transition element cation homeostasis (HP:0011030)1.88158583
131Methylmalonic acidemia (HP:0002912)1.88056438
132Abnormality of pyrimidine metabolism (HP:0004353)1.87452136
133Abnormality of macrophages (HP:0004311)1.85544495
134Esophageal varix (HP:0002040)1.85501441
135Interstitial pulmonary disease (HP:0006530)1.85163658
136Hypoplasia of the fovea (HP:0007750)1.83922449
137Aplasia/Hypoplasia of the fovea (HP:0008060)1.83922449
138Autoimmune thrombocytopenia (HP:0001973)1.83603289
139Patchy hypopigmentation of hair (HP:0011365)1.82301863
140Decreased electroretinogram (ERG) amplitude (HP:0000654)1.81521071
141Hyperinsulinemic hypoglycemia (HP:0000825)1.81260167
142Congenital sensorineural hearing impairment (HP:0008527)1.80937651
143Abnormality of methionine metabolism (HP:0010901)1.80701869
144Thrombophlebitis (HP:0004418)1.80076641
145Stomatitis (HP:0010280)1.78334160
146Hypophosphatemic rickets (HP:0004912)1.76472380
147Conjunctival hamartoma (HP:0100780)1.76007117
148Multiple enchondromatosis (HP:0005701)1.75995615
149Lethargy (HP:0001254)1.75948465
150Glycosuria (HP:0003076)1.75860989
151Abnormality of urine glucose concentration (HP:0011016)1.75860989
152Abnormality of vitamin B metabolism (HP:0004340)1.75409649
153Thyroiditis (HP:0100646)1.74687198
154Hyperglycemia (HP:0003074)1.74184848
155Abnormality of iron homeostasis (HP:0011031)1.73981227
156Large for gestational age (HP:0001520)1.73639170
157Abnormality of the basal ganglia (HP:0002134)1.73148692
158Azoospermia (HP:0000027)1.70118744
159Renal Fanconi syndrome (HP:0001994)1.69632162
160Abnormality of macular pigmentation (HP:0008002)1.68707382
161Hamartoma of the eye (HP:0010568)1.67751258
162Vascular calcification (HP:0004934)1.67300033
163True hermaphroditism (HP:0010459)1.66003739
164Alopecia of scalp (HP:0002293)1.65100578
165Retinal atrophy (HP:0001105)1.63401113

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TAOK35.66363515
2MST45.15571176
3BCKDK4.26551797
4ERN14.14495917
5NME22.93706740
6FLT32.88463454
7MAP3K122.83781309
8EEF2K2.75618296
9PKN22.59660687
10TRIB32.59460089
11KIT2.43836465
12FER2.40197347
13NUAK12.31813529
14TRIM282.28372849
15MAP4K12.25871460
16STK392.24876137
17OXSR12.17791190
18BMPR1B2.01340765
19GRK11.98845637
20MAPKAPK31.98018218
21ZAP701.87073822
22BMPR21.84495762
23MAP4K21.81503492
24ADRBK21.71124401
25TBK11.70429576
26CSF1R1.68009743
27SCYL21.65327799
28MAP2K31.64411089
29TYK21.61297846
30SIK11.60901345
31ERBB31.60723087
32PIM21.58907672
33EIF2AK31.56384758
34FGFR41.53703055
35LRRK21.46119863
36EPHA21.44062208
37INSRR1.42767710
38BTK1.41298182
39GRK61.39745702
40PTK61.35789296
41SIK31.33998045
42IRAK41.28548852
43TGFBR11.27257804
44PLK21.24914679
45MAP2K21.24097717
46PRKCI1.23954246
47MATK1.22611133
48MKNK21.20698839
49MUSK1.16239860
50STK101.15996041
51VRK21.14548387
52STK38L1.13295725
53RPS6KA41.12139571
54RIPK11.10584615
55PAK31.08063745
56BLK1.07972498
57MAP3K111.06591253
58JAK31.04618632
59IKBKE1.03466884
60ACVR1B1.02810695
61TESK21.02536750
62KDR1.01374998
63PIK3CG1.00725292
64TEC0.98858110
65ZAK0.98611749
66MAP3K100.98400647
67PDK20.98212673
68WNK30.96038685
69MAP2K60.95454049
70TGFBR20.95052476
71CASK0.93455093
72PAK40.93059344
73STK30.92906318
74PIK3CA0.92770619
75RPS6KB20.92496584
76EIF2AK10.91893994
77PLK30.91258526
78GRK70.89073068
79PRKG20.88621318
80MYLK0.88609093
81MAP3K80.87425025
82PRKCE0.85321727
83BCR0.85309848
84MAPK110.80859290
85TAOK10.79795295
86IRAK30.79381742
87FRK0.78156059
88TESK10.77942476
89PBK0.77866716
90CSNK1G30.77137041
91MAP3K20.76716529
92MAP3K30.75838748
93LMTK20.74980753
94SYK0.74809425
95CSNK1G10.73851115
96CDK190.72210128
97FGFR20.71754630
98EIF2AK20.71433272
99TNIK0.70352047
100WEE10.69053748
101AKT30.69007186
102BUB10.67813462
103TAOK20.67377892
104CSNK1A1L0.66260762
105MST1R0.64070661
106ABL10.63613901
107STK160.61281529
108LYN0.56723978
109MAPK150.55899036
110ITK0.55680363
111PTK20.54717495
112DAPK10.54095193
113JAK20.53845662
114CSK0.53813375
115PIM10.53709420
116PASK0.53515746
117MKNK10.53368418
118STK240.52658503
119DYRK1B0.51451987
120BRSK20.50415565
121LIMK10.50130134
122CSNK1G20.48524347
123CDK80.47868199
124MAP3K60.47743073
125JAK10.47369471
126CDK60.47210266
127MAPKAPK50.45764362
128ILK0.45485251
129CDK70.44762351
130NEK10.44652570
131MARK30.43876159
132CHUK0.43658417
133LCK0.43624077
134RAF10.43174189
135PINK10.41613845
136EPHB10.40725841
137IGF1R0.40568306
138ABL20.40512592
139CDK40.40432299
140EPHB20.39775262
141MAPK40.39276056
142PAK20.37706910
143DYRK30.37551359
144MAP3K140.37506078
145ADRBK10.37405562
146MAP3K50.36262187
147CAMKK20.35654386
148IKBKB0.35246340
149PRKCQ0.33948948
150TNK20.32868325
151MAP3K130.32797124
152MAP3K10.32078437
153ARAF0.31845007
154HCK0.31335124
155CAMK2D0.31251210
156NEK90.30966120
157GSK3A0.30867828
158AURKB0.30830156
159ROCK10.30611296
160FGFR30.30472608
161NLK0.30333777
162TAF10.29280981
163PHKG20.29133831
164TRPM70.26489711
165MAP2K10.25647045
166PRKCD0.23534576

Predicted pathways (KEGG)

RankGene SetZ-score
1Proteasome_Homo sapiens_hsa030502.91013092
2Ascorbate and aldarate metabolism_Homo sapiens_hsa000532.89375523
3Primary bile acid biosynthesis_Homo sapiens_hsa001202.78040389
4Folate biosynthesis_Homo sapiens_hsa007902.63610513
5Fat digestion and absorption_Homo sapiens_hsa049752.45383973
6Pentose and glucuronate interconversions_Homo sapiens_hsa000402.25978895
7Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006032.19060602
8Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.10441719
9Caffeine metabolism_Homo sapiens_hsa002322.09873037
10Glycine, serine and threonine metabolism_Homo sapiens_hsa002602.07397336
11Fatty acid degradation_Homo sapiens_hsa000712.01711211
12Drug metabolism - other enzymes_Homo sapiens_hsa009831.94119499
13Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.89170472
14Tryptophan metabolism_Homo sapiens_hsa003801.85053288
15Maturity onset diabetes of the young_Homo sapiens_hsa049501.75212492
16Collecting duct acid secretion_Homo sapiens_hsa049661.74290697
17Sulfur relay system_Homo sapiens_hsa041221.73897000
18Vitamin B6 metabolism_Homo sapiens_hsa007501.69397093
19Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.68029063
20Sphingolipid metabolism_Homo sapiens_hsa006001.67387454
21Selenocompound metabolism_Homo sapiens_hsa004501.65357983
22Cyanoamino acid metabolism_Homo sapiens_hsa004601.63938399
23Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.63860630
24Nitrogen metabolism_Homo sapiens_hsa009101.62948090
25Arginine biosynthesis_Homo sapiens_hsa002201.62158307
26Other glycan degradation_Homo sapiens_hsa005111.57306187
27Pentose phosphate pathway_Homo sapiens_hsa000301.56781833
28Complement and coagulation cascades_Homo sapiens_hsa046101.55378584
292-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.53891171
30Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.51387055
31Peroxisome_Homo sapiens_hsa041461.45601897
32Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.45471725
33Chemical carcinogenesis_Homo sapiens_hsa052041.45114099
34Rheumatoid arthritis_Homo sapiens_hsa053231.43535801
35Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.43015928
36Oxidative phosphorylation_Homo sapiens_hsa001901.42477000
37Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.40674770
38Propanoate metabolism_Homo sapiens_hsa006401.40525055
39Histidine metabolism_Homo sapiens_hsa003401.39809502
40Biosynthesis of amino acids_Homo sapiens_hsa012301.39339444
41Sulfur metabolism_Homo sapiens_hsa009201.38807520
42Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.37977515
43Glycosaminoglycan degradation_Homo sapiens_hsa005311.37961536
44Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.37037078
45Starch and sucrose metabolism_Homo sapiens_hsa005001.35669030
46Mineral absorption_Homo sapiens_hsa049781.32817144
47Staphylococcus aureus infection_Homo sapiens_hsa051501.30312950
48Protein export_Homo sapiens_hsa030601.29944292
49Carbon metabolism_Homo sapiens_hsa012001.28565577
50beta-Alanine metabolism_Homo sapiens_hsa004101.27754189
51N-Glycan biosynthesis_Homo sapiens_hsa005101.27695728
52Glutathione metabolism_Homo sapiens_hsa004801.26106306
53Vitamin digestion and absorption_Homo sapiens_hsa049771.25630310
54Asthma_Homo sapiens_hsa053101.24385349
55Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.19369071
56Pancreatic secretion_Homo sapiens_hsa049721.18669089
57Fatty acid metabolism_Homo sapiens_hsa012121.18566018
58Galactose metabolism_Homo sapiens_hsa000521.17487509
59SNARE interactions in vesicular transport_Homo sapiens_hsa041301.15002242
60Pyruvate metabolism_Homo sapiens_hsa006201.11038906
61PPAR signaling pathway_Homo sapiens_hsa033201.09015485
62One carbon pool by folate_Homo sapiens_hsa006701.06332556
63Cysteine and methionine metabolism_Homo sapiens_hsa002701.05129090
64Renin-angiotensin system_Homo sapiens_hsa046141.05023186
65Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.04629120
66Lysosome_Homo sapiens_hsa041421.02948015
67Type I diabetes mellitus_Homo sapiens_hsa049401.02041050
68Linoleic acid metabolism_Homo sapiens_hsa005911.01356598
69Arachidonic acid metabolism_Homo sapiens_hsa005901.01057639
70Glycerolipid metabolism_Homo sapiens_hsa005610.99770424
71Protein digestion and absorption_Homo sapiens_hsa049740.98585266
72Ether lipid metabolism_Homo sapiens_hsa005650.98344900
73Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.97658708
74Vibrio cholerae infection_Homo sapiens_hsa051100.97580748
75Fructose and mannose metabolism_Homo sapiens_hsa000510.96411682
76Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.91541198
77Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.91222029
78Intestinal immune network for IgA production_Homo sapiens_hsa046720.91198937
79Arginine and proline metabolism_Homo sapiens_hsa003300.89843335
80Legionellosis_Homo sapiens_hsa051340.88693699
81Non-homologous end-joining_Homo sapiens_hsa034500.87366250
82Bile secretion_Homo sapiens_hsa049760.87130189
83Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.85297212
84ABC transporters_Homo sapiens_hsa020100.83634963
85alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.82292206
86Ribosome_Homo sapiens_hsa030100.81721426
87Leishmaniasis_Homo sapiens_hsa051400.80187239
88Antigen processing and presentation_Homo sapiens_hsa046120.79104680
89DNA replication_Homo sapiens_hsa030300.78362489
90Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.78317792
91Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.78263142
92Butanoate metabolism_Homo sapiens_hsa006500.78005594
93Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.77804969
94Homologous recombination_Homo sapiens_hsa034400.76769635
95Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.71880682
96Retinol metabolism_Homo sapiens_hsa008300.70006822
97Allograft rejection_Homo sapiens_hsa053300.69079837
98RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.68166139
99Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.68012729
100Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.67910735
101Steroid biosynthesis_Homo sapiens_hsa001000.67089004
102Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.65384758
103Tyrosine metabolism_Homo sapiens_hsa003500.65330436
104Steroid hormone biosynthesis_Homo sapiens_hsa001400.62116594
105Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.61794674
106Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.60685907
107Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.57984171
108Autoimmune thyroid disease_Homo sapiens_hsa053200.54900149
109Phagosome_Homo sapiens_hsa041450.53641798
110Influenza A_Homo sapiens_hsa051640.53150165
111Parkinsons disease_Homo sapiens_hsa050120.52964661
112Toll-like receptor signaling pathway_Homo sapiens_hsa046200.52265304
113Tuberculosis_Homo sapiens_hsa051520.51963670
114RNA polymerase_Homo sapiens_hsa030200.51399832
115Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.49019154
116Pyrimidine metabolism_Homo sapiens_hsa002400.48424702
117Graft-versus-host disease_Homo sapiens_hsa053320.48362791
118Pertussis_Homo sapiens_hsa051330.47159162
119Basal transcription factors_Homo sapiens_hsa030220.46919405
120Metabolic pathways_Homo sapiens_hsa011000.46205316
121Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.42466197
122Base excision repair_Homo sapiens_hsa034100.40943508
123Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.39777907
124Phenylalanine metabolism_Homo sapiens_hsa003600.38899560
125Lysine degradation_Homo sapiens_hsa003100.38824015
126Apoptosis_Homo sapiens_hsa042100.37893728
127Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.37801947
128Hematopoietic cell lineage_Homo sapiens_hsa046400.37613028
129Measles_Homo sapiens_hsa051620.34464523
130Acute myeloid leukemia_Homo sapiens_hsa052210.30874298
131Hepatitis C_Homo sapiens_hsa051600.30060229
132B cell receptor signaling pathway_Homo sapiens_hsa046620.29598108
133Fatty acid elongation_Homo sapiens_hsa000620.29106811
134Osteoclast differentiation_Homo sapiens_hsa043800.28107874
135Shigellosis_Homo sapiens_hsa051310.26423541
136Primary immunodeficiency_Homo sapiens_hsa053400.25726353
137Toxoplasmosis_Homo sapiens_hsa051450.23603211

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