SLC39A12

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: Zinc is an essential cofactor for hundreds of enzymes. It is involved in protein, nucleic acid, carbohydrate, and lipid metabolism, as well as in the control of gene transcription, growth, development, and differentiation. SLC39A12 belongs to a subfamily of proteins that show structural characteristics of zinc transporters (Taylor and Nicholson, 2003 [PubMed 12659941]). NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1L-amino acid import (GO:0043092)6.31757135
2alanine transport (GO:0032328)6.26596645
3amino acid import (GO:0043090)6.15453623
4synaptic vesicle docking involved in exocytosis (GO:0016081)5.88547046
5C4-dicarboxylate transport (GO:0015740)5.42197806
6cellular potassium ion homeostasis (GO:0030007)5.21304319
7vitamin A metabolic process (GO:0006776)5.16100238
8synaptic vesicle exocytosis (GO:0016079)5.02141908
9chondroitin sulfate catabolic process (GO:0030207)4.95429657
10gamma-aminobutyric acid transport (GO:0015812)4.88515922
11negative regulation of astrocyte differentiation (GO:0048712)4.86641755
12sodium ion export (GO:0071436)4.85063322
13L-serine transport (GO:0015825)4.73126747
14regulation of synaptic vesicle exocytosis (GO:2000300)4.72877529
15neuronal ion channel clustering (GO:0045161)4.70382597
16cell communication by electrical coupling (GO:0010644)4.60371032
17axon ensheathment in central nervous system (GO:0032291)4.45178038
18central nervous system myelination (GO:0022010)4.45178038
19low-density lipoprotein particle remodeling (GO:0034374)4.42325452
20regulation of synaptic vesicle transport (GO:1902803)4.22043083
21potassium ion import (GO:0010107)4.20336931
22presynaptic membrane organization (GO:0097090)4.17418719
23neurotransmitter-gated ion channel clustering (GO:0072578)4.17417115
24postsynaptic membrane organization (GO:0001941)4.13143185
25presynaptic membrane assembly (GO:0097105)4.12961914
26locomotory exploration behavior (GO:0035641)4.10390488
27serine transport (GO:0032329)4.07424940
28neurotransmitter uptake (GO:0001504)3.97936974
29regulation of ventricular cardiac muscle cell membrane repolarization (GO:0060307)3.97137875
30positive regulation of calcium ion-dependent exocytosis (GO:0045956)3.94838055
31response to auditory stimulus (GO:0010996)3.94411163
32regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)3.89890194
33negative regulation of amyloid precursor protein catabolic process (GO:1902992)3.88760145
34microglial cell activation (GO:0001774)3.85503189
35dermatan sulfate metabolic process (GO:0030205)3.84455317
36cellular response to electrical stimulus (GO:0071257)3.79739882
37membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.78118677
38proline transport (GO:0015824)3.77789856
39cellular sodium ion homeostasis (GO:0006883)3.77209494
40adenine nucleotide transport (GO:0051503)3.71987605
41acidic amino acid transport (GO:0015800)3.71924998
42G-protein coupled glutamate receptor signaling pathway (GO:0007216)3.71243231
43positive regulation of cellular amide metabolic process (GO:0034250)3.69674630
44regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)3.68940530
45negative regulation of synaptic transmission, GABAergic (GO:0032229)3.64246991
46neurotransmitter transport (GO:0006836)3.62397801
47adenosine receptor signaling pathway (GO:0001973)3.61362992
48gamma-aminobutyric acid signaling pathway (GO:0007214)3.58560844
49ovulation cycle (GO:0042698)3.58332309
50one-carbon compound transport (GO:0019755)3.56703491
51cell communication by electrical coupling involved in cardiac conduction (GO:0086064)3.54814191
52regulation of beta-amyloid formation (GO:1902003)3.46054898
53auditory behavior (GO:0031223)3.45165637
54regulation of voltage-gated calcium channel activity (GO:1901385)3.43470694
55potassium ion homeostasis (GO:0055075)3.43094342
56glutamate receptor signaling pathway (GO:0007215)3.42276679
57ionotropic glutamate receptor signaling pathway (GO:0035235)3.40224160
58positive regulation of dendritic spine development (GO:0060999)3.38339571
59regulation of astrocyte differentiation (GO:0048710)3.35373023
60cellular response to cholesterol (GO:0071397)3.33381272
61positive regulation of potassium ion transmembrane transporter activity (GO:1901018)3.32158707
62regulation of neurotransmitter levels (GO:0001505)3.32017215
63negative regulation of sodium ion transport (GO:0010766)3.31034758
64long-term synaptic potentiation (GO:0060291)3.30971525
65neuronal action potential propagation (GO:0019227)3.28204570
66neuromuscular process controlling balance (GO:0050885)3.27925135
67negative regulation of dendrite morphogenesis (GO:0050774)3.27530340
68myelination (GO:0042552)3.26539646
69regulation of synaptic plasticity (GO:0048167)3.25071526
70hyperosmotic salinity response (GO:0042538)3.21921500
71regulation of ARF protein signal transduction (GO:0032012)3.21890107
72atrial cardiac muscle cell action potential (GO:0086014)3.20274587
73axon ensheathment (GO:0008366)3.19587357
74ensheathment of neurons (GO:0007272)3.19587357
75purine nucleotide transport (GO:0015865)3.19579880
76positive regulation of synapse maturation (GO:0090129)3.18698874
77myelin maintenance (GO:0043217)3.18462550
78regulation of neurotransmitter secretion (GO:0046928)3.17823416
79phosphorelay signal transduction system (GO:0000160)3.17182261
80negative regulation of hydrogen peroxide-induced cell death (GO:1903206)3.16364600
81regulation of short-term neuronal synaptic plasticity (GO:0048172)3.15268414
82positive regulation of membrane potential (GO:0045838)3.14239069
83L-glutamate transport (GO:0015813)3.13949180
84synaptic transmission, glutamatergic (GO:0035249)3.10916059
85regulation of synapse structural plasticity (GO:0051823)3.10823185
86astrocyte development (GO:0014002)3.10235898
87protein localization to synapse (GO:0035418)3.09902473
88long-chain fatty acid biosynthetic process (GO:0042759)3.09709298
89regulation of phospholipid biosynthetic process (GO:0071071)3.09021083
90positive regulation of inositol phosphate biosynthetic process (GO:0060732)3.08545875
91regulation of neurotransmitter transport (GO:0051588)3.08351073
92synaptic vesicle endocytosis (GO:0048488)3.06729164
93positive regulation of synaptic transmission, glutamatergic (GO:0051968)3.06178883
94relaxation of smooth muscle (GO:0044557)3.02414002
95cerebellar Purkinje cell differentiation (GO:0021702)3.01587379
96response to histamine (GO:0034776)3.01563429
97negative regulation of smoothened signaling pathway (GO:0045879)2.99494470
98negative regulation of norepinephrine secretion (GO:0010700)2.99121487
99regulation of excitatory postsynaptic membrane potential (GO:0060079)2.99083578
100regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act2.98050403
101regulation of female receptivity (GO:0045924)2.97208177
102regulation of dendritic spine development (GO:0060998)2.95853588
103purine ribonucleotide transport (GO:0015868)2.95275545
104kidney morphogenesis (GO:0060993)2.94150606
105positive regulation of excitatory postsynaptic membrane potential (GO:2000463)2.93843688
106transmission of nerve impulse (GO:0019226)2.93828448
107cytoskeletal anchoring at plasma membrane (GO:0007016)2.92588038
108protein-chromophore linkage (GO:0018298)2.92444962
109daunorubicin metabolic process (GO:0044597)2.89017082
110polyketide metabolic process (GO:0030638)2.89017082
111doxorubicin metabolic process (GO:0044598)2.89017082
112glial cell proliferation (GO:0014009)2.88559621
113aggressive behavior (GO:0002118)2.88377432
114glutamate secretion (GO:0014047)2.88272091
115positive regulation of potassium ion transport (GO:0043268)2.87207399
116regulation of neuronal synaptic plasticity (GO:0048168)2.86580781
117neuron cell-cell adhesion (GO:0007158)2.84646035
118negative regulation of inclusion body assembly (GO:0090084)2.84314244
119negative regulation of glial cell differentiation (GO:0045686)2.81637147
120regulation of respiratory gaseous exchange by neurological system process (GO:0002087)2.81523519
121regulation of dendritic spine morphogenesis (GO:0061001)2.81236052
122cellular response to sterol (GO:0036315)2.79652975
123membrane assembly (GO:0071709)2.79566881
124adult walking behavior (GO:0007628)2.79278749
125vocalization behavior (GO:0071625)2.79233185
126regulation of cell communication by electrical coupling (GO:0010649)2.78867424
127negative regulation of response to reactive oxygen species (GO:1901032)2.78379597
128regulation of hydrogen peroxide-induced cell death (GO:1903205)2.77767085
129regulation of glutamate receptor signaling pathway (GO:1900449)2.77719761
130nucleoside diphosphate catabolic process (GO:0009134)2.77453920
131mechanosensory behavior (GO:0007638)2.76357463
132regulation of long-term neuronal synaptic plasticity (GO:0048169)2.76355519
133regulation of membrane repolarization (GO:0060306)2.74138625
134long-term memory (GO:0007616)2.73629852
135L-amino acid transport (GO:0015807)2.72814932
136regulation of amyloid precursor protein catabolic process (GO:1902991)2.71010363
137regulation of synaptic transmission, glutamatergic (GO:0051966)2.68917899
138neurotransmitter secretion (GO:0007269)2.68863670
139cerebellar granule cell differentiation (GO:0021707)2.68416769
140negative regulation of cytosolic calcium ion concentration (GO:0051481)2.68350420
141neuroblast proliferation (GO:0007405)2.67652479
142regulation of cardiac muscle cell contraction (GO:0086004)2.61526455
143synaptic vesicle maturation (GO:0016188)2.61372363
144regulation of norepinephrine secretion (GO:0014061)2.61169194
145lens fiber cell development (GO:0070307)2.61089675
146regulation of inositol phosphate biosynthetic process (GO:0010919)2.59963242
147exploration behavior (GO:0035640)2.59524474
148regulation of glomerular filtration (GO:0003093)2.58236314
149neuron-neuron synaptic transmission (GO:0007270)2.57674308
150layer formation in cerebral cortex (GO:0021819)2.57626515
151oligodendrocyte differentiation (GO:0048709)2.55308406

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human3.99999022
2SUZ12_18555785_ChIP-Seq_MESCs_Mouse3.05687581
3SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.90566333
4SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.78618659
5GBX2_23144817_ChIP-Seq_PC3_Human2.73984321
6JARID2_20064375_ChIP-Seq_MESCs_Mouse2.61396584
7EED_16625203_ChIP-ChIP_MESCs_Mouse2.57526567
8SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.51658373
9RNF2_18974828_ChIP-Seq_MESCs_Mouse2.51006327
10EZH2_18974828_ChIP-Seq_MESCs_Mouse2.51006327
11SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.45518368
12AR_21572438_ChIP-Seq_LNCaP_Human2.40274780
13MTF2_20144788_ChIP-Seq_MESCs_Mouse2.38387359
14JARID2_20075857_ChIP-Seq_MESCs_Mouse2.38334720
15IKZF1_21737484_ChIP-ChIP_HCT116_Human2.36272596
16SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.28687709
17EZH2_27304074_Chip-Seq_ESCs_Mouse2.16503656
18RNF2_27304074_Chip-Seq_ESCs_Mouse2.12362289
19REST_21632747_ChIP-Seq_MESCs_Mouse2.06072675
20DROSHA_22980978_ChIP-Seq_HELA_Human1.98220178
21EZH2_27294783_Chip-Seq_ESCs_Mouse1.95743746
22GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.92397732
23SUZ12_27294783_Chip-Seq_ESCs_Mouse1.91517802
24SMAD_19615063_ChIP-ChIP_OVARY_Human1.85112184
25GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.76369646
26PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.72294531
27CDX2_19796622_ChIP-Seq_MESCs_Mouse1.61490097
28PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.60579961
29CTBP2_25329375_ChIP-Seq_LNCAP_Human1.55711421
30RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.52807468
31RARB_27405468_Chip-Seq_BRAIN_Mouse1.50468087
32PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.49475843
33CBX2_27304074_Chip-Seq_ESCs_Mouse1.48963968
34TP53_16413492_ChIP-PET_HCT116_Human1.47340057
35RXR_22108803_ChIP-Seq_LS180_Human1.46577968
36REST_18959480_ChIP-ChIP_MESCs_Mouse1.46432179
37P300_19829295_ChIP-Seq_ESCs_Human1.46313689
38AR_25329375_ChIP-Seq_VCAP_Human1.42515655
39NR3C1_21868756_ChIP-Seq_MCF10A_Human1.42245012
40MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.39703642
41SMAD4_21799915_ChIP-Seq_A2780_Human1.39029625
42SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.38663485
43ERG_21242973_ChIP-ChIP_JURKAT_Human1.38026774
44* SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.37779910
45TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.34949047
46PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.34748530
47PIAS1_25552417_ChIP-Seq_VCAP_Human1.34707971
48SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.34075430
49ZFP57_27257070_Chip-Seq_ESCs_Mouse1.32924979
50CTBP1_25329375_ChIP-Seq_LNCAP_Human1.32524385
51RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.32013206
52BCAT_22108803_ChIP-Seq_LS180_Human1.30190716
53TRIM28_21343339_ChIP-Seq_HEK293_Human1.29992278
54RING1B_27294783_Chip-Seq_ESCs_Mouse1.28874914
55ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.25309477
56TP53_18474530_ChIP-ChIP_U2OS_Human1.22875731
57THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.22359202
58EP300_21415370_ChIP-Seq_HL-1_Mouse1.21627904
59GATA1_26923725_Chip-Seq_HPCs_Mouse1.21319575
60CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.20044096
61TRIM28_17542650_ChIP-ChIP_NTERA2_Human1.19774523
62BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.18962931
63AR_19668381_ChIP-Seq_PC3_Human1.17617562
64CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.17037643
65STAT3_23295773_ChIP-Seq_U87_Human1.15889587
66ZNF217_24962896_ChIP-Seq_MCF-7_Human1.11071328
67SMAD3_21741376_ChIP-Seq_EPCs_Human1.10625415
68TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.08613341
69SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.08440982
70NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.08378805
71OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.07765769
72NR3C1_23031785_ChIP-Seq_PC12_Mouse1.07652172
73SOX2_21211035_ChIP-Seq_LN229_Gbm1.07556960
74WT1_25993318_ChIP-Seq_PODOCYTE_Human1.07539922
75EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.05489674
76VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.04244995
77TOP2B_26459242_ChIP-Seq_MCF-7_Human1.03898801
78TP53_20018659_ChIP-ChIP_R1E_Mouse1.02142229
79CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.01414564
80KDM2B_26808549_Chip-Seq_K562_Human1.00308549
81TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.00297676
82TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.99730396
83MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse0.98788842
84AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.98758439
85SMAD4_21741376_ChIP-Seq_HESCs_Human0.98363402
86UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human0.98286119
87RING1B_27294783_Chip-Seq_NPCs_Mouse0.97499593
88DNAJC2_21179169_ChIP-ChIP_NT2_Human0.97023081
89YAP1_20516196_ChIP-Seq_MESCs_Mouse0.95663428
90ESR1_22446102_ChIP-Seq_UTERUS_Mouse0.95107969
91SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.95024792
92RUNX2_22187159_ChIP-Seq_PCA_Human0.94804002
93P53_22127205_ChIP-Seq_FIBROBLAST_Human0.94487094
94TFAP2C_20629094_ChIP-Seq_MCF-7_Human0.94062146
95ARNT_22903824_ChIP-Seq_MCF-7_Human0.93797414
96POU3F2_20337985_ChIP-ChIP_501MEL_Human0.92963681
97LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.92771049
98STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse0.92020001
99POU5F1_26923725_Chip-Seq_MESODERM_Mouse0.91534985
100TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.91534985
101SMAD3_21741376_ChIP-Seq_ESCs_Human0.90868294
102RNF2_27304074_Chip-Seq_NSC_Mouse0.90439496
103TCF4_23295773_ChIP-Seq_U87_Human0.89954101
104GF1_26923725_Chip-Seq_HPCs_Mouse0.88754862
105MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.88327703
106* TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse0.87881518
107SMAD3_21741376_ChIP-Seq_HESCs_Human0.87571011
108CTNNB1_20460455_ChIP-Seq_HCT116_Human0.86540669
109TAL1_26923725_Chip-Seq_HPCs_Mouse0.85901447
110PRDM14_20953172_ChIP-Seq_ESCs_Human0.85292013
111AHR_22903824_ChIP-Seq_MCF-7_Human0.85112254
112TCF4_18268006_ChIP-ChIP_LS174T_Human0.84964394
113RCOR3_21632747_ChIP-Seq_MESCs_Mouse0.84485184
114ESR2_21235772_ChIP-Seq_MCF-7_Human0.84471995
115* NANOG_18555785_Chip-Seq_ESCs_Mouse0.83609926

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003011_delayed_dark_adaptation5.98096629
2MP0003690_abnormal_glial_cell4.20184232
3MP0004885_abnormal_endolymph4.01650687
4MP0003878_abnormal_ear_physiology3.79849315
5MP0005377_hearing/vestibular/ear_phenot3.79849315
6MP0004859_abnormal_synaptic_plasticity3.56476873
7MP0009384_cardiac_valve_regurgitation3.42939307
8MP0005423_abnormal_somatic_nervous3.15853289
9MP0004270_analgesia2.93938176
10MP0009780_abnormal_chondrocyte_physiolo2.80420916
11MP0001486_abnormal_startle_reflex2.77281464
12MP0003635_abnormal_synaptic_transmissio2.58804336
13MP0005646_abnormal_pituitary_gland2.54356268
14MP0004858_abnormal_nervous_system2.49991417
15MP0001502_abnormal_circadian_rhythm2.49566389
16MP0003329_amyloid_beta_deposits2.45727630
17MP0009046_muscle_twitch2.37958459
18MP0009745_abnormal_behavioral_response2.30000239
19MP0002254_reproductive_system_inflammat2.26287756
20MP0000566_synostosis2.26112240
21MP0002064_seizures2.23161865
22MP0002572_abnormal_emotion/affect_behav2.22601821
23MP0002063_abnormal_learning/memory/cond2.09117698
24MP0001440_abnormal_grooming_behavior2.08944904
25MP0003879_abnormal_hair_cell2.06553145
26MP0001485_abnormal_pinna_reflex2.05833523
27MP0003880_abnormal_central_pattern2.02197083
28MP0003136_yellow_coat_color1.88532083
29MP0001501_abnormal_sleep_pattern1.88458314
30MP0003075_altered_response_to1.82533305
31MP0003634_abnormal_glial_cell1.77319818
32MP0003633_abnormal_nervous_system1.77030482
33MP0002557_abnormal_social/conspecific_i1.67316362
34MP0004019_abnormal_vitamin_homeostasis1.66888698
35MP0003172_abnormal_lysosome_physiology1.66076513
36MP0002734_abnormal_mechanical_nocicepti1.63167712
37MP0001968_abnormal_touch/_nociception1.61614738
38MP0008569_lethality_at_weaning1.58073831
39MP0002272_abnormal_nervous_system1.55265114
40MP0006276_abnormal_autonomic_nervous1.54073683
41MP0003279_aneurysm1.49469170
42MP0002067_abnormal_sensory_capabilities1.46420168
43MP0002736_abnormal_nociception_after1.44290447
44MP0000569_abnormal_digit_pigmentation1.41424303
45MP0003137_abnormal_impulse_conducting1.40588900
46MP0001986_abnormal_taste_sensitivity1.36861793
47MP0003631_nervous_system_phenotype1.36735610
48MP0004811_abnormal_neuron_physiology1.36589952
49MP0005058_abnormal_lysosome_morphology1.33969270
50MP0001299_abnormal_eye_distance/1.31984593
51MP0002733_abnormal_thermal_nociception1.30591112
52MP0000778_abnormal_nervous_system1.29802563
53MP0005670_abnormal_white_adipose1.29476433
54MP0000604_amyloidosis1.28527766
55MP0002638_abnormal_pupillary_reflex1.27810227
56MP0005171_absent_coat_pigmentation1.27685562
57MP0004215_abnormal_myocardial_fiber1.23231115
58MP0001963_abnormal_hearing_physiology1.19973602
59MP0004924_abnormal_behavior1.17530581
60MP0005386_behavior/neurological_phenoty1.17530581
61MP0001905_abnormal_dopamine_level1.13358373
62MP0005551_abnormal_eye_electrophysiolog1.09980547
63MP0001984_abnormal_olfaction1.09448064
64MP0001970_abnormal_pain_threshold1.07101216
65MP0004145_abnormal_muscle_electrophysio1.05572485
66MP0001346_abnormal_lacrimal_gland1.04883976
67MP0000026_abnormal_inner_ear1.04283363
68MP0004142_abnormal_muscle_tone1.02454893
69MP0005167_abnormal_blood-brain_barrier1.02448232
70MP0002882_abnormal_neuron_morphology1.00641955
71MP0002229_neurodegeneration1.00355445
72MP0002089_abnormal_postnatal_growth/wei0.99656618
73MP0002066_abnormal_motor_capabilities/c0.99247412
74MP0005332_abnormal_amino_acid0.98204758
75MP0003632_abnormal_nervous_system0.95578819
76MP0000920_abnormal_myelination0.95115788
77MP0005595_abnormal_vascular_smooth0.94129243
78MP0002090_abnormal_vision0.90130311
79MP0004742_abnormal_vestibular_system0.89994425
80MP0006292_abnormal_olfactory_placode0.89912104
81MP0005645_abnormal_hypothalamus_physiol0.89269740
82MP0000955_abnormal_spinal_cord0.88429458
83MP0001853_heart_inflammation0.88215345
84MP0005253_abnormal_eye_physiology0.86478737
85MP0008874_decreased_physiological_sensi0.83864064
86MP0002152_abnormal_brain_morphology0.82673514
87MP0005647_abnormal_sex_gland0.81896400
88MP0004043_abnormal_pH_regulation0.80044033
89MP0002184_abnormal_innervation0.78111262
90MP0001324_abnormal_eye_pigmentation0.77257455
91MP0003787_abnormal_imprinting0.73855445
92MP0002909_abnormal_adrenal_gland0.73227130
93MP0004883_abnormal_blood_vessel0.73105313
94MP0001958_emphysema0.72861053
95MP0005535_abnormal_body_temperature0.71828074
96MP0005195_abnormal_posterior_eye0.71637668
97MP0004130_abnormal_muscle_cell0.70877675
98MP0000049_abnormal_middle_ear0.68665982
99MP0002735_abnormal_chemical_nociception0.67453829
100MP0005166_decreased_susceptibility_to0.66899175
101MP0005165_increased_susceptibility_to0.65436007
102MP0001177_atelectasis0.65055475
103MP0005391_vision/eye_phenotype0.64880828
104MP0000428_abnormal_craniofacial_morphol0.64431081
105MP0004085_abnormal_heartbeat0.64381781
106MP0003938_abnormal_ear_development0.63401912
107MP0008872_abnormal_physiological_respon0.63249846
108MP0005623_abnormal_meninges_morphology0.62961890
109MP0009840_abnormal_foam_cell0.62023804
110MP0000631_abnormal_neuroendocrine_gland0.61858810
111MP0000647_abnormal_sebaceous_gland0.61376264
112MP0001529_abnormal_vocalization0.61240297
113MP0002752_abnormal_somatic_nervous0.60675679
114MP0002822_catalepsy0.58839147
115MP0002133_abnormal_respiratory_system0.49972142
116MP0005388_respiratory_system_phenotype0.49972142
117MP0003123_paternal_imprinting0.48446971
118MP0002069_abnormal_eating/drinking_beha0.45622967
119MP0003183_abnormal_peptide_metabolism0.45124351
120MP0003122_maternal_imprinting0.42555494
121MP0005174_abnormal_tail_pigmentation0.41498840
122MP0000462_abnormal_digestive_system0.41253082
123MP0010386_abnormal_urinary_bladder0.40771399
124MP0001943_abnormal_respiration0.39772075

Predicted human phenotypes

RankGene SetZ-score
1Aplasia involving bones of the upper limbs (HP:0009823)6.69031981
2Aplasia of the phalanges of the hand (HP:0009802)6.69031981
3Aplasia involving bones of the extremities (HP:0009825)6.69031981
4Abnormality of secondary sexual hair (HP:0009888)5.68732506
5Abnormality of the axillary hair (HP:0100134)5.68732506
6Onycholysis (HP:0001806)4.96887534
7Megalencephaly (HP:0001355)4.75239085
8Peripheral hypomyelination (HP:0007182)4.64275624
9Diplopia (HP:0000651)4.55547819
10Abnormality of binocular vision (HP:0011514)4.55547819
11Hemiparesis (HP:0001269)4.49896802
12Scanning speech (HP:0002168)4.30745882
13Choroideremia (HP:0001139)4.18267622
14Neurofibrillary tangles (HP:0002185)4.11078371
15Abnormality of nail color (HP:0100643)3.99926176
16Ankle clonus (HP:0011448)3.98883657
17Febrile seizures (HP:0002373)3.91411798
18Focal motor seizures (HP:0011153)3.85490841
19Hemiplegia (HP:0002301)3.68589789
20J-shaped sella turcica (HP:0002680)3.63904628
21Atonic seizures (HP:0010819)3.57589585
22Hypoplastic left heart (HP:0004383)3.53567495
23Decreased electroretinogram (ERG) amplitude (HP:0000654)3.51339229
24Congenital stationary night blindness (HP:0007642)3.40119347
25Spastic gait (HP:0002064)3.37973712
26Truncal ataxia (HP:0002078)3.36607705
27Scotoma (HP:0000575)3.16453113
28Epileptic encephalopathy (HP:0200134)3.05220021
29Degeneration of the lateral corticospinal tracts (HP:0002314)3.04490000
30Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)3.04490000
31Urinary bladder sphincter dysfunction (HP:0002839)3.03355321
32Increased circulating renin level (HP:0000848)3.02112250
33Cerebral inclusion bodies (HP:0100314)3.01499454
34Intention tremor (HP:0002080)2.99912195
35Dysmetria (HP:0001310)2.94819224
36Mixed hearing impairment (HP:0000410)2.94131463
37Broad face (HP:0000283)2.91512409
38Ulnar claw (HP:0001178)2.90436162
39Alacrima (HP:0000522)2.88455090
40Supranuclear gaze palsy (HP:0000605)2.87066603
41Decreased central vision (HP:0007663)2.86320487
42Abnormality of the corticospinal tract (HP:0002492)2.85514509
43Cranial hyperostosis (HP:0004437)2.83516079
44Obstructive sleep apnea (HP:0002870)2.82853562
45Absent hair (HP:0002298)2.81262995
46Termporal pattern (HP:0011008)2.76626567
47Insidious onset (HP:0003587)2.76626567
48Broad alveolar ridges (HP:0000187)2.71723331
49Bony spicule pigmentary retinopathy (HP:0007737)2.71128299
50Lower limb muscle weakness (HP:0007340)2.71048994
51Abnormality of the dental pulp (HP:0006479)2.68598047
52Hypoplastic heart (HP:0001961)2.67065122
53Abnormality of the fovea (HP:0000493)2.66647629
54Narrow nasal bridge (HP:0000446)2.66579245
55Myokymia (HP:0002411)2.66460663
56Bundle branch block (HP:0011710)2.64018099
57Mutism (HP:0002300)2.63293697
58Synostosis involving the elbow (HP:0003938)2.58907610
59Humeroradial synostosis (HP:0003041)2.58907610
60Torticollis (HP:0000473)2.57396765
61Pseudobulbar signs (HP:0002200)2.57028794
62Urinary urgency (HP:0000012)2.56880258
63Confusion (HP:0001289)2.56815333
64Neuronal loss in central nervous system (HP:0002529)2.56540238
65Dialeptic seizures (HP:0011146)2.55323065
66Absence seizures (HP:0002121)2.52453953
67Attenuation of retinal blood vessels (HP:0007843)2.49147854
68Abnormality of hair growth rate (HP:0011363)2.48674454
69Slow-growing hair (HP:0002217)2.48674454
70Biconcave vertebral bodies (HP:0004586)2.48595130
71Back pain (HP:0003418)2.46787032
72Craniofacial hyperostosis (HP:0004493)2.44943466
73Papilledema (HP:0001085)2.42982489
74Action tremor (HP:0002345)2.41955693
75Brittle hair (HP:0002299)2.40507052
76Impaired vibration sensation in the lower limbs (HP:0002166)2.40361099
77Focal seizures (HP:0007359)2.39514691
78Tetraplegia (HP:0002445)2.38068984
79Deformed sella turcica (HP:0002681)2.36642497
80Short hallux (HP:0010109)2.36287908
81Visual hallucinations (HP:0002367)2.36064119
82Postural tremor (HP:0002174)2.35796818
83Dysostosis multiplex (HP:0000943)2.34903619
84Long nose (HP:0003189)2.34650920
85Abnormality of the dental root (HP:0006486)2.34647309
86Taurodontia (HP:0000679)2.34647309
87Abnormality of permanent molar morphology (HP:0011071)2.34647309
88Decreased lacrimation (HP:0000633)2.33563906
89Fibular aplasia (HP:0002990)2.33291491
90Abnormality of the middle phalanges of the toes (HP:0010183)2.31992813
91Macular degeneration (HP:0000608)2.29613145
92Clumsiness (HP:0002312)2.28245793
93Blepharitis (HP:0000498)2.28072668
94Decreased number of peripheral myelinated nerve fibers (HP:0003380)2.27783372
95Facial shape deformation (HP:0011334)2.27266000
96Potter facies (HP:0002009)2.27266000
97Central scotoma (HP:0000603)2.24857667
98Progressive cerebellar ataxia (HP:0002073)2.24332969
99Generalized tonic-clonic seizures (HP:0002069)2.24235170
100Postural instability (HP:0002172)2.23678398
101Increased CSF protein (HP:0002922)2.23656050
102Abnormality of molar (HP:0011077)2.22670182
103Abnormality of molar morphology (HP:0011070)2.22670182
104Decreased motor nerve conduction velocity (HP:0003431)2.21248661
105Clonus (HP:0002169)2.17756092
106Foot dorsiflexor weakness (HP:0009027)2.17179837
107Short middle phalanx of the 5th finger (HP:0004220)2.17173022
108Bradykinesia (HP:0002067)2.16522009
109Upper limb muscle weakness (HP:0003484)2.15641914
110Tetraparesis (HP:0002273)2.15538865
111Progressive neurologic deterioration (HP:0002344)2.15110885
112Multifactorial inheritance (HP:0001426)2.14365267
113Epileptiform EEG discharges (HP:0011182)2.13963325
114Poor eye contact (HP:0000817)2.13878220
115Apathy (HP:0000741)2.11826451
116Annular pancreas (HP:0001734)2.11539850
117Hyperventilation (HP:0002883)2.10385996
118Rigidity (HP:0002063)2.10325778
119Status epilepticus (HP:0002133)2.10308877
120Delusions (HP:0000746)2.10103750
121Aplasia/Hypoplasia of the hallux (HP:0008362)2.09799039
122Split foot (HP:0001839)2.09725243
123Dysdiadochokinesis (HP:0002075)2.09635040
124Abnormality of macular pigmentation (HP:0008002)2.07727184
125Polyphagia (HP:0002591)2.05807840
126Hypopigmentation of the fundus (HP:0007894)2.05462368
127Depression (HP:0000716)2.05270194
128Sleep apnea (HP:0010535)2.04090468
129Abnormal eating behavior (HP:0100738)2.01792623
130Neonatal short-limb short stature (HP:0008921)2.01652600
131Anxiety (HP:0000739)1.99321648
132Hammertoe (HP:0001765)1.97643081
133Focal dystonia (HP:0004373)1.97545377
134Spinal canal stenosis (HP:0003416)1.97267922
135Abnormality of the foot musculature (HP:0001436)1.96779972
136Aplasia/Hypoplasia of the middle phalanx of the 5th finger (HP:0009161)1.96032372
137Onion bulb formation (HP:0003383)1.95043649
138Dry hair (HP:0011359)1.94429770
139Bronchomalacia (HP:0002780)1.93277489
140Diminished motivation (HP:0000745)1.92022087
141Adactyly (HP:0009776)1.90855260
142Cervical subluxation (HP:0003308)1.89665433
143Abnormality of the periventricular white matter (HP:0002518)1.89398833
144Segmental peripheral demyelination/remyelination (HP:0003481)1.89325837
145Abnormality of liposaccharide metabolism (HP:0010968)1.89197931
146Abnormality of glycosphingolipid metabolism (HP:0004343)1.89197931
147Abnormality of glycolipid metabolism (HP:0010969)1.89197931
148Hypoalphalipoproteinemia (HP:0003233)1.89112480
149Corneal erosion (HP:0200020)1.88686663
150Stereotypic behavior (HP:0000733)1.87378123
151Craniofacial dystonia (HP:0012179)1.86103669
152Polydipsia (HP:0001959)1.85444497
153Abnormal drinking behavior (HP:0030082)1.85444497
154Maternal diabetes (HP:0009800)1.84835045
155Cerebral hypomyelination (HP:0006808)1.84175264
156Thickened helices (HP:0000391)1.82668135
157Depressed nasal tip (HP:0000437)1.82410102
158Impaired vibratory sensation (HP:0002495)1.81600493
159Broad-based gait (HP:0002136)1.81201511
160Urinary glycosaminoglycan excretion (HP:0003541)1.80800355
161Mucopolysacchariduria (HP:0008155)1.80800355
162Abnormal urine output (HP:0012590)1.79188229
163Aplasia/Hypoplasia involving the femoral head and neck (HP:0009108)1.77240163
164Arterial tortuosity (HP:0005116)1.76411127
165Atrioventricular block (HP:0001678)1.74922285
166Abnormality of mucopolysaccharide metabolism (HP:0011020)1.74816947
167Abnormality of polysaccharide metabolism (HP:0011012)1.74816947
168Abnormality of glycosaminoglycan metabolism (HP:0004371)1.74816947
169Aplasia/hypoplasia of the femur (HP:0005613)1.73528381
170Hyperglycinuria (HP:0003108)1.72839809
171Aplasia/Hypoplasia of the phalanges of the 5th finger (HP:0009376)1.72654932
172Abnormality of the middle phalanx of the 5th finger (HP:0004219)1.70335105
173Homocystinuria (HP:0002156)1.69010517
174Abnormality of homocysteine metabolism (HP:0010919)1.69010517
175Aplasia/Hypoplasia of the clavicles (HP:0006710)1.68175343

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MUSK6.89095092
2TNIK5.40998161
3EPHA43.73920707
4NTRK23.43376001
5PHKG22.65361900
6PHKG12.65361900
7NTRK32.54784583
8LMTK22.52290111
9MKNK22.50975220
10MAP2K71.81596603
11TRIB31.76035191
12GRK71.70671114
13CASK1.69770006
14MINK11.68382832
15MAPK121.67807357
16PRKD31.66841493
17NTRK11.62115087
18MARK11.60174827
19STK391.54231205
20GRK51.51812991
21TGFBR21.40438757
22GRK11.39929545
23MAP3K41.39789295
24MAP3K91.39663232
25PLK21.37329807
26MAPK131.31204318
27PRKCG1.29992952
28SGK21.20988608
29MOS1.20158095
30MAPK71.12043321
31SIK11.11368578
32MET1.10255139
33MAP3K131.09350529
34SGK31.08988401
35ADRBK11.04599839
36SGK4941.02029923
37SGK2231.02029923
38CDK51.00070520
39CAMKK10.99317824
40LATS20.98818698
41PNCK0.98141986
42PAK60.97448762
43ARAF0.94328504
44PINK10.93179925
45MAP2K40.91694267
46TNK20.91022691
47WNK10.90688413
48STK380.84783087
49PRKCE0.84607910
50CAMK2A0.83118597
51STK110.82515373
52DYRK1A0.79048266
53FGFR20.78796077
54BMPR20.76901445
55RIPK10.76704581
56MARK20.76093551
57RAF10.75839102
58CDK190.74148422
59CDK30.73739053
60MAPKAPK50.73188190
61MKNK10.72834744
62FGFR30.71667760
63NEK60.70290265
64CAMK2G0.68449521
65TYRO30.67388828
66RIPK40.65440018
67BRAF0.64304511
68CAMK40.63888039
69DAPK20.63737258
70MAP3K70.63502407
71INSRR0.62797327
72DAPK10.61924738
73FES0.60605210
74PRKCZ0.60268788
75IRAK30.60131079
76BMPR1B0.58288679
77SGK10.57344846
78PRPF4B0.55710997
79PRKG10.54236189
80RET0.52691434
81FGR0.51406624
82ALK0.51057921
83CDK150.50879299
84MAP3K10.50862750
85IGF1R0.50767878
86PRKD10.50538020
87PTK2B0.50477207
88CAMK1G0.50194997
89CAMK10.50106841
90SIK20.49444066
91PRKCA0.48767696
92RPS6KA30.48492900
93CDK180.47853175
94CDC42BPA0.47506196
95CAMK2B0.47164273
96MAP3K20.46287583
97PDK10.45662323
98ROCK10.45608119
99CSNK1G20.45461348
100ROCK20.44584154
101BRSK10.44461730
102CSNK1D0.44314977
103PRKACG0.44243525
104PRKCH0.42355463
105KSR10.41853299
106MAPK40.41266893
107PAK30.40955091
108PRKACB0.40734355
109DDR20.40197055
110CDK11A0.39986020
111JAK20.38841926
112PKN10.38657673
113PRKACA0.38076486
114CAMK2D0.37976149
115PRKCB0.37755680
116ERBB40.35491336
117UHMK10.35182235
118PBK0.34933948
119BMX0.34610405
120MAPK100.34401240
121CAMKK20.33881626
122OXSR10.33725942
123PRKAA20.33603994
124PDPK10.33264344
125FYN0.32475420
126FGFR10.32147342
127WNK40.32137174
128CDK140.31319088
129SRC0.30517052
130KSR20.29528637

Predicted pathways (KEGG)

RankGene SetZ-score
1Nitrogen metabolism_Homo sapiens_hsa009104.96346832
2Fatty acid biosynthesis_Homo sapiens_hsa000614.43239162
3Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049643.36458793
4Nicotine addiction_Homo sapiens_hsa050332.95620775
5Phototransduction_Homo sapiens_hsa047442.31410183
6GABAergic synapse_Homo sapiens_hsa047272.18811879
7Glutamatergic synapse_Homo sapiens_hsa047242.09770305
8Salivary secretion_Homo sapiens_hsa049702.07748738
9Fatty acid metabolism_Homo sapiens_hsa012121.93294836
10Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.78618023
11Circadian entrainment_Homo sapiens_hsa047131.74967495
12Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.74081175
13Gastric acid secretion_Homo sapiens_hsa049711.68432703
14Insulin secretion_Homo sapiens_hsa049111.64857402
15Circadian rhythm_Homo sapiens_hsa047101.64775734
16Vitamin B6 metabolism_Homo sapiens_hsa007501.63620274
17Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.63569233
18Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.59858994
19Morphine addiction_Homo sapiens_hsa050321.58824431
20Histidine metabolism_Homo sapiens_hsa003401.58514435
21Olfactory transduction_Homo sapiens_hsa047401.54127431
22Glycosaminoglycan degradation_Homo sapiens_hsa005311.48547063
23Fatty acid degradation_Homo sapiens_hsa000711.41098658
24Bile secretion_Homo sapiens_hsa049761.35351340
25Dorso-ventral axis formation_Homo sapiens_hsa043201.34213199
26Calcium signaling pathway_Homo sapiens_hsa040201.32669909
27Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.30397620
28Cocaine addiction_Homo sapiens_hsa050301.28851530
29Long-term potentiation_Homo sapiens_hsa047201.28417068
30Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.25156381
31Synaptic vesicle cycle_Homo sapiens_hsa047211.19245574
32Amphetamine addiction_Homo sapiens_hsa050311.17962793
33PPAR signaling pathway_Homo sapiens_hsa033201.17919128
34Taste transduction_Homo sapiens_hsa047421.15733686
35Renin secretion_Homo sapiens_hsa049241.13135186
36Steroid biosynthesis_Homo sapiens_hsa001001.11985797
37Mineral absorption_Homo sapiens_hsa049781.09308083
38beta-Alanine metabolism_Homo sapiens_hsa004101.09012789
39Other types of O-glycan biosynthesis_Homo sapiens_hsa005141.08328134
40Inositol phosphate metabolism_Homo sapiens_hsa005621.01763494
41Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.01558744
42cAMP signaling pathway_Homo sapiens_hsa040241.00941374
43Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.00180118
44Pancreatic secretion_Homo sapiens_hsa049720.96594020
45Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.96438622
46Carbohydrate digestion and absorption_Homo sapiens_hsa049730.95562816
47Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.93879675
48Ether lipid metabolism_Homo sapiens_hsa005650.92027559
49Glycerophospholipid metabolism_Homo sapiens_hsa005640.87828786
50Serotonergic synapse_Homo sapiens_hsa047260.87036304
51Ras signaling pathway_Homo sapiens_hsa040140.86388867
52Aldosterone synthesis and secretion_Homo sapiens_hsa049250.86122571
53Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.84418588
54Gap junction_Homo sapiens_hsa045400.83390631
55Cholinergic synapse_Homo sapiens_hsa047250.82844814
56Lysosome_Homo sapiens_hsa041420.79249148
57Dopaminergic synapse_Homo sapiens_hsa047280.77291285
58Oocyte meiosis_Homo sapiens_hsa041140.76832010
59Long-term depression_Homo sapiens_hsa047300.76682028
60Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.73909749
61Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.70717305
62Phospholipase D signaling pathway_Homo sapiens_hsa040720.69783102
63Oxytocin signaling pathway_Homo sapiens_hsa049210.69533822
64Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.68537344
65Other glycan degradation_Homo sapiens_hsa005110.68297379
66Neurotrophin signaling pathway_Homo sapiens_hsa047220.68287830
67Melanogenesis_Homo sapiens_hsa049160.68242028
68Adipocytokine signaling pathway_Homo sapiens_hsa049200.67923325
69Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.67449097
70Caffeine metabolism_Homo sapiens_hsa002320.67287891
71Vibrio cholerae infection_Homo sapiens_hsa051100.66523924
72cGMP-PKG signaling pathway_Homo sapiens_hsa040220.66465058
73Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.65104856
74MAPK signaling pathway_Homo sapiens_hsa040100.64390637
75Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.64185391
76Thyroid hormone signaling pathway_Homo sapiens_hsa049190.63845234
77Thyroid hormone synthesis_Homo sapiens_hsa049180.63353036
78Cardiac muscle contraction_Homo sapiens_hsa042600.61160929
79Endocytosis_Homo sapiens_hsa041440.59714825
80Arginine and proline metabolism_Homo sapiens_hsa003300.59655300
81Dilated cardiomyopathy_Homo sapiens_hsa054140.59403440
82African trypanosomiasis_Homo sapiens_hsa051430.59149883
83GnRH signaling pathway_Homo sapiens_hsa049120.58904408
84Collecting duct acid secretion_Homo sapiens_hsa049660.58771674
85Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.58623616
86Sphingolipid metabolism_Homo sapiens_hsa006000.58493645
87Fatty acid elongation_Homo sapiens_hsa000620.58233881
88Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.57809480
89Phosphatidylinositol signaling system_Homo sapiens_hsa040700.56652486
90Tight junction_Homo sapiens_hsa045300.54536961
91Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.54056686
92Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.53784619
93Propanoate metabolism_Homo sapiens_hsa006400.52915304
94Fructose and mannose metabolism_Homo sapiens_hsa000510.52670891
95VEGF signaling pathway_Homo sapiens_hsa043700.50720384
96Arginine biosynthesis_Homo sapiens_hsa002200.49777202
97Glycerolipid metabolism_Homo sapiens_hsa005610.49704262
98Basal cell carcinoma_Homo sapiens_hsa052170.47876612
99Butanoate metabolism_Homo sapiens_hsa006500.47369677
100Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.47234280
101Ovarian steroidogenesis_Homo sapiens_hsa049130.47016434
102Estrogen signaling pathway_Homo sapiens_hsa049150.45793096
103Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.42393323
104Vitamin digestion and absorption_Homo sapiens_hsa049770.41418231
105Sphingolipid signaling pathway_Homo sapiens_hsa040710.41066301
106Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.41001993
107Glucagon signaling pathway_Homo sapiens_hsa049220.37002458
108Choline metabolism in cancer_Homo sapiens_hsa052310.36906469
109Endometrial cancer_Homo sapiens_hsa052130.36867022
110Wnt signaling pathway_Homo sapiens_hsa043100.36822625
111Hippo signaling pathway_Homo sapiens_hsa043900.36422450
112ErbB signaling pathway_Homo sapiens_hsa040120.35809994
113Glioma_Homo sapiens_hsa052140.35673411
114Prion diseases_Homo sapiens_hsa050200.35539997
115Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.35451204
116ABC transporters_Homo sapiens_hsa020100.34904211
117Axon guidance_Homo sapiens_hsa043600.34155189
118Type II diabetes mellitus_Homo sapiens_hsa049300.33289559
119Rap1 signaling pathway_Homo sapiens_hsa040150.33187292
120Peroxisome_Homo sapiens_hsa041460.32314580
121Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.31828320
122Vascular smooth muscle contraction_Homo sapiens_hsa042700.30776700
123Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.29282391
124mTOR signaling pathway_Homo sapiens_hsa041500.27609762
125Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.26634883
126HIF-1 signaling pathway_Homo sapiens_hsa040660.21643087

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