SLC39A14

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: Zinc is an essential cofactor for hundreds of enzymes. It is involved in protein, nucleic acid, carbohydrate, and lipid metabolism, as well as in the control of gene transcription, growth, development, and differentiation. SLC39A14 belongs to a subfamily of proteins that show structural characteristics of zinc transporters (Taylor and Nicholson, 2003 [PubMed 12659941]). NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)6.84630506
2L-phenylalanine catabolic process (GO:0006559)6.84630506
3erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)6.54960866
4L-phenylalanine metabolic process (GO:0006558)6.54960866
5aromatic amino acid family catabolic process (GO:0009074)6.16911708
6triglyceride-rich lipoprotein particle remodeling (GO:0034370)6.08317310
7kynurenine metabolic process (GO:0070189)5.71474999
8indole-containing compound catabolic process (GO:0042436)5.67856831
9indolalkylamine catabolic process (GO:0046218)5.67856831
10tryptophan catabolic process (GO:0006569)5.67856831
11negative regulation of fibrinolysis (GO:0051918)5.51637346
12urea cycle (GO:0000050)5.49159502
13urea metabolic process (GO:0019627)5.49159502
14alpha-linolenic acid metabolic process (GO:0036109)5.41799226
15regulation of protein activation cascade (GO:2000257)5.41205281
16tryptophan metabolic process (GO:0006568)5.35537905
17peptidyl-glutamic acid carboxylation (GO:0017187)5.35056249
18protein carboxylation (GO:0018214)5.35056249
19bile acid biosynthetic process (GO:0006699)5.35054545
20glyoxylate metabolic process (GO:0046487)5.31092030
21regulation of fibrinolysis (GO:0051917)5.28433101
22complement activation, alternative pathway (GO:0006957)5.22803644
23high-density lipoprotein particle remodeling (GO:0034375)5.18934588
24cysteine metabolic process (GO:0006534)5.05324371
25regulation of complement activation (GO:0030449)5.02299000
26nitrogen cycle metabolic process (GO:0071941)4.98238408
27regulation of triglyceride catabolic process (GO:0010896)4.79946607
28homocysteine metabolic process (GO:0050667)4.73235843
29serine family amino acid catabolic process (GO:0009071)4.72770391
30sulfur amino acid catabolic process (GO:0000098)4.72090064
31reverse cholesterol transport (GO:0043691)4.69055544
32bile acid metabolic process (GO:0008206)4.63007238
33fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)4.61174161
34lysine catabolic process (GO:0006554)4.57676101
35lysine metabolic process (GO:0006553)4.57676101
36triglyceride homeostasis (GO:0070328)4.53927644
37acylglycerol homeostasis (GO:0055090)4.53927644
38protein-lipid complex remodeling (GO:0034368)4.51098871
39macromolecular complex remodeling (GO:0034367)4.51098871
40plasma lipoprotein particle remodeling (GO:0034369)4.51098871
41regulation of cholesterol esterification (GO:0010872)4.50653336
42aromatic amino acid family metabolic process (GO:0009072)4.44813694
43negative regulation of sterol transport (GO:0032372)4.42144400
44negative regulation of cholesterol transport (GO:0032375)4.42144400
45phospholipid efflux (GO:0033700)4.40514082
46plasma lipoprotein particle clearance (GO:0034381)4.36275730
47amino-acid betaine metabolic process (GO:0006577)4.34972733
48regulation of apoptotic cell clearance (GO:2000425)4.34497526
49tyrosine metabolic process (GO:0006570)4.33806817
50alpha-amino acid catabolic process (GO:1901606)4.27293245
51intestinal absorption (GO:0050892)4.23765264
52bile acid and bile salt transport (GO:0015721)4.21095829
53dicarboxylic acid biosynthetic process (GO:0043650)4.16307427
54epoxygenase P450 pathway (GO:0019373)4.16187281
55regulation of cholesterol homeostasis (GO:2000188)4.13736052
56glutamate metabolic process (GO:0006536)4.12413852
57cholesterol efflux (GO:0033344)4.07398994
58glycine metabolic process (GO:0006544)4.07252842
59cellular modified amino acid catabolic process (GO:0042219)4.05617910
60cellular glucuronidation (GO:0052695)4.04986944
61proline metabolic process (GO:0006560)4.01990725
62fibrinolysis (GO:0042730)4.00626720
63phospholipid homeostasis (GO:0055091)4.00055378
64coenzyme catabolic process (GO:0009109)3.98439686
65imidazole-containing compound metabolic process (GO:0052803)3.96841193
66indolalkylamine metabolic process (GO:0006586)3.95309402
67plasma lipoprotein particle assembly (GO:0034377)3.92899903
68cellular amino acid catabolic process (GO:0009063)3.90640635
69intestinal cholesterol absorption (GO:0030299)3.89222858
70proline biosynthetic process (GO:0006561)3.87021004
71acute-phase response (GO:0006953)3.85086586
72serine family amino acid metabolic process (GO:0009069)3.83677264
73positive regulation of lipid catabolic process (GO:0050996)3.83088289
74regulation of bile acid biosynthetic process (GO:0070857)3.82974853
75cellular ketone body metabolic process (GO:0046950)3.82044308
76cellular biogenic amine catabolic process (GO:0042402)3.80896275
77amine catabolic process (GO:0009310)3.80896275
78exogenous drug catabolic process (GO:0042738)3.80381068
79positive regulation of triglyceride lipase activity (GO:0061365)3.78288919
80positive regulation of lipoprotein lipase activity (GO:0051006)3.78288919
81drug catabolic process (GO:0042737)3.73751259
82cholesterol homeostasis (GO:0042632)3.73402483
83negative regulation of protein activation cascade (GO:2000258)3.72830495
84benzene-containing compound metabolic process (GO:0042537)3.72819844
85sterol homeostasis (GO:0055092)3.69655559
86arginine metabolic process (GO:0006525)3.69198132
87positive regulation of heterotypic cell-cell adhesion (GO:0034116)3.65016553
88serine family amino acid biosynthetic process (GO:0009070)3.63899527
89positive regulation of fatty acid beta-oxidation (GO:0032000)3.63144394
90lipoprotein metabolic process (GO:0042157)3.62806992
91ethanol oxidation (GO:0006069)3.62288028
92protein-lipid complex assembly (GO:0065005)3.61796038
93very-low-density lipoprotein particle assembly (GO:0034379)3.60143144
94complement activation, classical pathway (GO:0006958)3.60141477
95negative regulation of hemostasis (GO:1900047)3.58803413
96negative regulation of blood coagulation (GO:0030195)3.58803413
97complement activation (GO:0006956)3.55322071
98omega-hydroxylase P450 pathway (GO:0097267)3.54971072
99protein activation cascade (GO:0072376)3.54627357
100opsonization (GO:0008228)3.54137065
101regulation of plasminogen activation (GO:0010755)3.53655632
102glucuronate metabolic process (GO:0019585)3.52576022
103uronic acid metabolic process (GO:0006063)3.52576022
104acetyl-CoA metabolic process (GO:0006084)3.52016446
105low-density lipoprotein particle remodeling (GO:0034374)3.51536988
106negative regulation of lipase activity (GO:0060192)3.50497296
107plasma lipoprotein particle organization (GO:0071827)3.50090264
108protein-lipid complex subunit organization (GO:0071825)3.48114393
109blood coagulation, intrinsic pathway (GO:0007597)3.44999025
1102-oxoglutarate metabolic process (GO:0006103)3.41876856
111negative regulation of wound healing (GO:0061045)3.40232794
112negative regulation of coagulation (GO:0050819)3.40082742
113COPII vesicle coating (GO:0048208)3.30297053
114regulation of systemic arterial blood pressure by renin-angiotensin (GO:0003081)3.24492229
115regulation of cholesterol biosynthetic process (GO:0045540)3.23751737
116glutamine family amino acid biosynthetic process (GO:0009084)3.19905914
117maintenance of protein localization in endoplasmic reticulum (GO:0035437)3.18232459
118positive regulation of hemostasis (GO:1900048)3.16777477
119positive regulation of blood coagulation (GO:0030194)3.16777477
120Golgi transport vesicle coating (GO:0048200)3.15739795
121COPI coating of Golgi vesicle (GO:0048205)3.15739795
122positive regulation of fatty acid biosynthetic process (GO:0045723)3.03997323
123protein retention in ER lumen (GO:0006621)3.03202362
124nucleotide-sugar biosynthetic process (GO:0009226)2.97904099
125positive regulation of extracellular matrix organization (GO:1903055)2.94534688
126positive regulation of coagulation (GO:0050820)2.92908288
127regulation of humoral immune response (GO:0002920)2.90338328
128daunorubicin metabolic process (GO:0044597)2.87954492
129polyketide metabolic process (GO:0030638)2.87954492
130doxorubicin metabolic process (GO:0044598)2.87954492
131L-serine metabolic process (GO:0006563)2.87169869
132negative regulation of complement activation (GO:0045916)2.84941634
1334-hydroxyproline metabolic process (GO:0019471)2.84781547
134negative regulation of lipid transport (GO:0032369)2.79630819
135gap junction assembly (GO:0016264)2.78159827
136cholesterol transport (GO:0030301)2.76308207
137sterol transport (GO:0015918)2.76308207
138renal system process involved in regulation of systemic arterial blood pressure (GO:0003071)2.74679917

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1* RXR_22158963_ChIP-Seq_LIVER_Mouse7.72839338
2PPARA_22158963_ChIP-Seq_LIVER_Mouse6.73162248
3* LXR_22158963_ChIP-Seq_LIVER_Mouse6.14584348
4EGR1_23403033_ChIP-Seq_LIVER_Mouse6.07626850
5FOXO1_23066095_ChIP-Seq_LIVER_Mouse4.86373932
6PPARG_19300518_ChIP-PET_3T3-L1_Mouse4.58534489
7CEBPA_23403033_ChIP-Seq_LIVER_Mouse4.41284085
8* NR1I2_20693526_ChIP-Seq_LIVER_Mouse4.05312823
9E2F7_22180533_ChIP-Seq_HELA_Human3.62796548
10CEBPB_23403033_ChIP-Seq_LIVER_Mouse3.36480448
11AR_21909140_ChIP-Seq_LNCAP_Human3.05454203
12TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse2.13928324
13CLOCK_20551151_ChIP-Seq_293T_Human2.10008957
14SMAD4_19686287_ChIP-ChIP_HaCaT_Human2.01666094
15ESR1_17901129_ChIP-ChIP_LIVER_Mouse11.0369409
16STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.97310298
17* POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.93618220
18* TCF7L2_21901280_ChIP-Seq_H4IIE_Rat1.90955700
19HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.88220726
20* PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.87251277
21* FOXA2_19822575_ChIP-Seq_HepG2_Human1.74863858
22MYC_18555785_ChIP-Seq_MESCs_Mouse1.74429121
23NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.59482350
24ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.57989398
25STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.57368490
26RARG_19884340_ChIP-ChIP_MEFs_Mouse1.57323236
27EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.54478198
28THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.51125075
29* HNF4A_19822575_ChIP-Seq_HepG2_Human1.42629823
30GATA1_22025678_ChIP-Seq_K562_Human1.38070015
31TCF3_18692474_ChIP-Seq_MEFs_Mouse1.37872734
32ZFX_18555785_ChIP-Seq_MESCs_Mouse1.37312345
33* TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.35422548
34ESR1_15608294_ChIP-ChIP_MCF-7_Human1.33725579
35ESR2_21235772_ChIP-Seq_MCF-7_Human1.31649959
36* SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.30813085
37TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.28154365
38NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.27675233
39EOMES_20176728_ChIP-ChIP_TSCs_Mouse1.25030063
40IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.25010450
41MYC_19079543_ChIP-ChIP_MESCs_Mouse1.22684150
42FOXM1_23109430_ChIP-Seq_U2OS_Human1.22053239
43KLF4_18555785_ChIP-Seq_MESCs_Mouse1.21639710
44TP63_17297297_ChIP-ChIP_HaCaT_Human1.21345887
45WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.20104521
46RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.20091399
47ESR1_21235772_ChIP-Seq_MCF-7_Human1.20044217
48CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.19457126
49SOX2_27498859_Chip-Seq_STOMACH_Mouse1.17970864
50IRF8_22096565_ChIP-ChIP_GC-B_Human1.17909229
51TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.16842358
52NKX2-5_21415370_ChIP-Seq_HL-1_Mouse1.15640948
53NELFA_20434984_ChIP-Seq_ESCs_Mouse1.15597291
54EGR1_19374776_ChIP-ChIP_THP-1_Human1.15208608
55* SOX17_20123909_ChIP-Seq_XEN_Mouse1.14459114
56HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.14287732
57KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.13710599
58HTT_18923047_ChIP-ChIP_STHdh_Human1.12709002
59NACC1_18358816_ChIP-ChIP_MESCs_Mouse1.08415977
60* Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.05915559
61PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.05296631
62* KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.03146529
63RXRA_24833708_ChIP-Seq_LIVER_Mouse1.02681750
64* SALL4_18804426_ChIP-ChIP_XEN_Mouse1.00914489
65* MYC_19030024_ChIP-ChIP_MESCs_Mouse1.00477416
66GATA3_20176728_ChIP-ChIP_TSCs_Mouse1.00259212
67TRIM28_21343339_ChIP-Seq_HEK293_Human0.99426006
68BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.99220174
69ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.99066456
70* GATA4_25053715_ChIP-Seq_YYC3_Human0.98896702
71UBF1/2_26484160_Chip-Seq_HMECs_Human0.98553867
72SMAD2_18955504_ChIP-ChIP_HaCaT_Human0.96970286
73SMAD3_18955504_ChIP-ChIP_HaCaT_Human0.96970286
74FOXO3_23340844_ChIP-Seq_DLD1_Human0.95143794
75ELK3_25401928_ChIP-Seq_HUVEC_Human0.93570210
76ZNF263_19887448_ChIP-Seq_K562_Human0.92560454
77EP300_21415370_ChIP-Seq_HL-1_Mouse0.92462980
78MYCN_18555785_ChIP-Seq_MESCs_Mouse0.92460334
79PPAR_26484153_Chip-Seq_NCI-H1993_Human0.92110370
80TCF4_18268006_ChIP-ChIP_LS174T_Human0.90646261
81ZNF652_21678463_ChIP-ChIP_ZR75-1_Human0.89099597
82ZFP281_18757296_ChIP-ChIP_E14_Mouse0.88802453
83* SOX2_18358816_ChIP-ChIP_MESCs_Mouse0.87411467
84* NANOG_21062744_ChIP-ChIP_HESCs_Human0.85922151
85* TCF3_18692474_ChIP-Seq_MESCs_Mouse0.85708623
86* NANOG_18555785_ChIP-Seq_MESCs_Mouse0.85670155
87AR_21915096_ChIP-Seq_LNCaP-1F5_Human0.85268034
88* ZIC3_20872845_ChIP-ChIP_MESCs_Mouse0.85243387
89UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human0.85163737
90TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.84845526
91NFE2L2_20460467_ChIP-Seq_MEFs_Mouse0.84787580
92NRF2_20460467_ChIP-Seq_MEFs_Mouse0.84787580
93STAT3_1855785_ChIP-Seq_MESCs_Mouse0.84521830
94CDX2_20551321_ChIP-Seq_CACO-2_Human0.78872053
95* GATA6_25053715_ChIP-Seq_YYC3_Human0.76215415
96FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human0.73785877
97AUTS2_25519132_ChIP-Seq_293T-REX_Human0.73018378
98NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human0.72833615
99FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse0.71982686
100* NR0B1_18358816_ChIP-ChIP_MESCs_Mouse0.71528353
101ESR1_22446102_ChIP-Seq_UTERUS_Mouse0.68504566
102LXR_22292898_ChIP-Seq_THP-1_Human0.67257643
103SREBP1_19666523_ChIP-Seq_LIVER_Mouse0.66418842
104ESR1_20079471_ChIP-ChIP_T-47D_Human0.64263389
105RACK7_27058665_Chip-Seq_MCF-7_Human0.63295412
106RARA_24833708_ChIP-Seq_LIVER_Mouse0.63152445
107KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human0.63024008
108ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human0.61835933
109TBX20_22328084_ChIP-Seq_HEART_Mouse0.61349901
110TBX20_22080862_ChIP-Seq_HEART_Mouse0.61349901
111* SOX2_20726797_ChIP-Seq_SW620_Human0.60657677
112PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse0.60098618
113SREBP2_21459322_ChIP-Seq_LIVER_Mouse0.59180471
114FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human0.58840486
115ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.57708625
116FOXA1_25552417_ChIP-Seq_VCAP_Human0.57441947
117PPARG_20887899_ChIP-Seq_3T3-L1_Mouse0.57113808
118FOXA1_26743006_Chip-Seq_LNCaP-abl_Human0.57100836
119NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse0.56227710
120GATA2_21666600_ChIP-Seq_HMVEC_Human0.55994281
121EGR1_19032775_ChIP-ChIP_M12_Human0.55411268
122BRD4_27068464_Chip-Seq_AML-cells_Mouse0.55362519
123PPARD_23208498_ChIP-Seq_MDA-MB-231_Human0.55256643
124HIF1A_21447827_ChIP-Seq_MCF-7_Human0.54522645
125* ATF3_27146783_Chip-Seq_COLON_Human0.54195282
126GATA2_19941826_ChIP-Seq_K562_Human0.54034022
127GATA3_24758297_ChIP-Seq_MCF-7_Human0.51957083
128GATA1_19941826_ChIP-Seq_K562_Human0.51253870
129ZNF217_24962896_ChIP-Seq_MCF-7_Human0.50961837
130KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human0.50666467
131ESRRB_18555785_ChIP-Seq_MESCs_Mouse0.49547647
132CJUN_26792858_Chip-Seq_BT549_Human0.48477069
133RARB_24833708_ChIP-Seq_LIVER_Mouse0.48474169
134* CEBPB_22108803_ChIP-Seq_LS180_Human0.48377497
135RUNX2_24764292_ChIP-Seq_MC3T3_Mouse0.48260707
136SOX9_24532713_ChIP-Seq_HFSC_Mouse0.48187403
137P300_27058665_Chip-Seq_ZR-75-30cells_Human0.47922223
138SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse0.46723178
139SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse0.46164930
140CBP_21632823_ChIP-Seq_H3396_Human0.46086566
141* TFAP2C_20629094_ChIP-Seq_MCF-7_Human0.46029810
142NFIB_24661679_ChIP-Seq_LUNG_Mouse0.45737416
143CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse0.44447760

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002139_abnormal_hepatobiliary_system7.50536587
2MP0005360_urolithiasis7.29380990
3MP0005085_abnormal_gallbladder_physiolo6.01738909
4MP0005365_abnormal_bile_salt5.65498859
5MP0008875_abnormal_xenobiotic_pharmacok4.52831599
6MP0003252_abnormal_bile_duct3.92550489
7MP0003806_abnormal_nucleotide_metabolis3.79679658
8MP0010329_abnormal_lipoprotein_level3.44870724
9MP0009840_abnormal_foam_cell3.30918505
10MP0005083_abnormal_biliary_tract3.20732449
11MP0004272_abnormal_basement_membrane2.92403042
12MP0003195_calcinosis2.76355759
13MP0001666_abnormal_nutrient_absorption2.75509798
14MP0003941_abnormal_skin_development2.63059475
15MP0005332_abnormal_amino_acid2.56132661
16MP0003191_abnormal_cellular_cholesterol2.41494348
17MP0003705_abnormal_hypodermis_morpholog2.33906201
18MP0000609_abnormal_liver_physiology2.15203194
19MP0004019_abnormal_vitamin_homeostasis2.05979854
20MP0002118_abnormal_lipid_homeostasis2.01942976
21MP0005257_abnormal_intraocular_pressure1.90388874
22MP0005319_abnormal_enzyme/_coenzyme1.79345801
23MP0003868_abnormal_feces_composition1.77232057
24MP0002138_abnormal_hepatobiliary_system1.75540703
25MP0002089_abnormal_postnatal_growth/wei1.58813180
26MP0003950_abnormal_plasma_membrane1.53128904
27MP0002254_reproductive_system_inflammat1.46063887
28MP0003123_paternal_imprinting1.39737543
29MP0005409_darkened_coat_color1.39238525
30MP0000566_synostosis1.37581737
31MP0005584_abnormal_enzyme/coenzyme_acti1.37506571
32MP0003122_maternal_imprinting1.31607550
33MP0009697_abnormal_copulation1.25928453
34MP0001764_abnormal_homeostasis1.23933764
35MP0005076_abnormal_cell_differentiation1.22156469
36MP0006054_spinal_hemorrhage1.21514934
37MP0000598_abnormal_liver_morphology1.19809776
38MP0004233_abnormal_muscle_weight1.18774374
39MP0009780_abnormal_chondrocyte_physiolo1.18663863
40MP0009643_abnormal_urine_homeostasis1.18356965
41MP0005451_abnormal_body_composition1.16568508
42MP0001730_embryonic_growth_arrest1.16524133
43MP0003011_delayed_dark_adaptation1.12773764
44MP0000604_amyloidosis1.11508069
45MP0005670_abnormal_white_adipose1.10516816
46MP0004858_abnormal_nervous_system1.08772831
47MP0009763_increased_sensitivity_to1.07451181
48MP0009764_decreased_sensitivity_to1.05859187
49MP0009672_abnormal_birth_weight1.03651932
50MP0010368_abnormal_lymphatic_system1.02473364
51MP0003656_abnormal_erythrocyte_physiolo1.01617672
52MP0008438_abnormal_cutaneous_collagen0.97973905
53MP0002697_abnormal_eye_size0.97223167
54MP0003186_abnormal_redox_activity0.96239274
55MP0005647_abnormal_sex_gland0.94616142
56MP0005623_abnormal_meninges_morphology0.94025001
57MP0004957_abnormal_blastocyst_morpholog0.93184367
58MP0004130_abnormal_muscle_cell0.93161240
59MP0001849_ear_inflammation0.90979414
60MP0005058_abnormal_lysosome_morphology0.89999487
61MP0009384_cardiac_valve_regurgitation0.88433451
62MP0008469_abnormal_protein_level0.87871710
63MP0002086_abnormal_extraembryonic_tissu0.84860024
64MP0000762_abnormal_tongue_morphology0.83384427
65MP0003115_abnormal_respiratory_system0.83211740
66MP0010234_abnormal_vibrissa_follicle0.82952219
67MP0003718_maternal_effect0.82737349
68MP0000003_abnormal_adipose_tissue0.81720898
69MP0003091_abnormal_cell_migration0.81568172
70MP0002971_abnormal_brown_adipose0.81452132
71MP0002877_abnormal_melanocyte_morpholog0.80578414
72MP0009642_abnormal_blood_homeostasis0.80354747
73MP0005220_abnormal_exocrine_pancreas0.79158726
74MP0002896_abnormal_bone_mineralization0.78715458
75MP0009053_abnormal_anal_canal0.78154036
76MP0005023_abnormal_wound_healing0.77833604
77MP0005666_abnormal_adipose_tissue0.77822478
78MP0003890_abnormal_embryonic-extraembry0.77630560
79MP0003111_abnormal_nucleus_morphology0.76977765
80MP0003300_gastrointestinal_ulcer0.76860770
81MP0003567_abnormal_fetal_cardiomyocyte0.75881393
82MP0001672_abnormal_embryogenesis/_devel0.75823617
83MP0005380_embryogenesis_phenotype0.75823617
84MP0003984_embryonic_growth_retardation0.75800879
85MP0003436_decreased_susceptibility_to0.72951463
86MP0002078_abnormal_glucose_homeostasis0.72797749
87MP0005636_abnormal_mineral_homeostasis0.72686770
88MP0002088_abnormal_embryonic_growth/wei0.72487760
89MP0001881_abnormal_mammary_gland0.72161988
90MP0005084_abnormal_gallbladder_morpholo0.71369276
91MP0005330_cardiomyopathy0.70502746
92MP0005376_homeostasis/metabolism_phenot0.70423069
93MP0005334_abnormal_fat_pad0.70340813
94MP0000467_abnormal_esophagus_morphology0.68992375
95MP0001299_abnormal_eye_distance/0.68017797
96MP0002876_abnormal_thyroid_physiology0.67894265
97MP0006138_congestive_heart_failure0.67478414
98MP0009765_abnormal_xenobiotic_induced0.67459077
99MP0003942_abnormal_urinary_system0.67331429
100MP0000767_abnormal_smooth_muscle0.66585283
101MP0000537_abnormal_urethra_morphology0.66296827
102MP0010630_abnormal_cardiac_muscle0.65856161
103MP0003693_abnormal_embryo_hatching0.65836659
104MP0005408_hypopigmentation0.65253460
105MP0008932_abnormal_embryonic_tissue0.64965744
106MP0002092_abnormal_eye_morphology0.64462344
107MP0003385_abnormal_body_wall0.63662712
108MP0010030_abnormal_orbit_morphology0.63218344
109MP0002060_abnormal_skin_morphology0.61513061
110MP0005197_abnormal_uvea_morphology0.61285628
111MP0000579_abnormal_nail_morphology0.60389400
112MP0005448_abnormal_energy_balance0.59969040
113MP0002168_other_aberrant_phenotype0.59531433
114MP0002084_abnormal_developmental_patter0.59345579
115MP0005395_other_phenotype0.59277952
116MP0001661_extended_life_span0.58837845
117MP0003937_abnormal_limbs/digits/tail_de0.58775332
118MP0001697_abnormal_embryo_size0.58172968
119MP0002080_prenatal_lethality0.58111316
120MP0002837_dystrophic_cardiac_calcinosis0.57419170
121MP0005275_abnormal_skin_tensile0.57012829
122MP0003690_abnormal_glial_cell0.55951486
123MP0001756_abnormal_urination0.55782607
124MP0003453_abnormal_keratinocyte_physiol0.55602307
125MP0005266_abnormal_metabolism0.54985209
126MP0005464_abnormal_platelet_physiology0.54852137
127MP0004264_abnormal_extraembryonic_tissu0.52927227
128MP0002136_abnormal_kidney_physiology0.51360643
129MP0005166_decreased_susceptibility_to0.51292394
130MP0002796_impaired_skin_barrier0.51207663
131MP0003566_abnormal_cell_adhesion0.50363470
132MP0001243_abnormal_dermal_layer0.49938362
133MP0003075_altered_response_to0.49928473
134MP0003724_increased_susceptibility_to0.49566386
135MP0005535_abnormal_body_temperature0.47238425
136MP0008873_increased_physiological_sensi0.47234065
137MP0004185_abnormal_adipocyte_glucose0.47171502
138MP0005248_abnormal_Harderian_gland0.46514265
139MP0006036_abnormal_mitochondrial_physio0.45727261
140MP0009115_abnormal_fat_cell0.44355020
141MP0003303_peritoneal_inflammation0.44295354
142MP0010352_gastrointestinal_tract_polyps0.43985287
143MP0002928_abnormal_bile_duct0.43940821
144MP0000427_abnormal_hair_cycle0.40736097
145MP0000249_abnormal_blood_vessel0.40106816
146MP0003329_amyloid_beta_deposits0.39940901
147MP0004947_skin_inflammation0.39801563
148MP0005164_abnormal_response_to0.39018876
149MP0006082_CNS_inflammation0.38185560
150MP0000639_abnormal_adrenal_gland0.37989465
151MP0002269_muscular_atrophy0.37981302
152MP0005375_adipose_tissue_phenotype0.37401644
153MP0003638_abnormal_response/metabolism_0.35749601
154MP0001533_abnormal_skeleton_physiology0.35416316
155MP0001915_intracranial_hemorrhage0.34557825

Predicted human phenotypes

RankGene SetZ-score
1Deep venous thrombosis (HP:0002625)7.14727729
2Intrahepatic cholestasis (HP:0001406)6.79962523
3Abnormality of aromatic amino acid family metabolism (HP:0004338)6.46958709
4Abnormality of monocarboxylic acid metabolism (HP:0010996)6.32510178
5Xanthomatosis (HP:0000991)6.15532623
6Prolonged partial thromboplastin time (HP:0003645)6.00227586
7Hypobetalipoproteinemia (HP:0003563)5.98705163
8Complement deficiency (HP:0004431)5.34066164
9Hyperlipoproteinemia (HP:0010980)5.13195955
10Hypolipoproteinemia (HP:0010981)4.80500419
11Abnormality of the common coagulation pathway (HP:0010990)4.75063908
12Epidermoid cyst (HP:0200040)4.49011700
13Hypoalphalipoproteinemia (HP:0003233)4.47048578
14Joint hemorrhage (HP:0005261)4.45184584
15Abnormality of glutamine family amino acid metabolism (HP:0010902)4.35735593
16Abnormality of the level of lipoprotein cholesterol (HP:0010979)4.34249061
17Hyperammonemia (HP:0001987)4.23648057
18Abnormality of sulfur amino acid metabolism (HP:0004339)4.18568743
19Abnormality of complement system (HP:0005339)4.00518577
20Abnormality of methionine metabolism (HP:0010901)3.96946780
21Abnormality of aspartate family amino acid metabolism (HP:0010899)3.93939288
22Hyperglycinemia (HP:0002154)3.91660309
23Fat malabsorption (HP:0002630)3.91259060
24Ketosis (HP:0001946)3.90096564
25Protrusio acetabuli (HP:0003179)3.79040322
26Abnormality of the intrinsic pathway (HP:0010989)3.75137046
27Hypoglycemic coma (HP:0001325)3.72725859
28Myocardial infarction (HP:0001658)3.61322786
29Hyperglycinuria (HP:0003108)3.61239015
30Abnormality of glycine metabolism (HP:0010895)3.56226901
31Abnormality of serine family amino acid metabolism (HP:0010894)3.56226901
32Hypercholesterolemia (HP:0003124)3.50624700
33Premature rupture of membranes (HP:0001788)3.44450960
34Abnormality of pyrimidine metabolism (HP:0004353)3.42907247
35Spontaneous abortion (HP:0005268)3.39987318
36Conjugated hyperbilirubinemia (HP:0002908)3.38349523
37Skin nodule (HP:0200036)3.03563124
38Abnormality of nucleobase metabolism (HP:0010932)2.96575840
39Abnormality of fatty-acid metabolism (HP:0004359)2.91036074
40Hepatocellular carcinoma (HP:0001402)2.91025354
41Abnormality of long-chain fatty-acid metabolism (HP:0010964)2.89653025
42Abnormality of carpal bone ossification (HP:0006257)2.88166397
43Hyperbilirubinemia (HP:0002904)2.83510243
44Ketoacidosis (HP:0001993)2.81157831
45Systemic lupus erythematosus (HP:0002725)2.81109388
46Steatorrhea (HP:0002570)2.79755060
47Vascular calcification (HP:0004934)2.75939742
48Abnormality of purine metabolism (HP:0004352)2.73410137
49Abnormality of serum amino acid levels (HP:0003112)2.69963484
50Esophageal varix (HP:0002040)2.65925146
51Mitral stenosis (HP:0001718)2.63344859
52Cardiovascular calcification (HP:0011915)2.63097181
53Flat acetabular roof (HP:0003180)2.59198243
54Spastic diplegia (HP:0001264)2.55381527
55Vertebral compression fractures (HP:0002953)2.52710557
56Hypochromic microcytic anemia (HP:0004840)2.50451977
57Delayed CNS myelination (HP:0002188)2.48817618
58Gingival bleeding (HP:0000225)2.48007832
59Glomerulonephritis (HP:0000099)2.45609592
60Hypoglycemic seizures (HP:0002173)2.45187502
61Abnormal delivery (HP:0001787)2.44383193
62Metabolic acidosis (HP:0001942)2.39797909
63Acanthocytosis (HP:0001927)2.38813666
64Small epiphyses (HP:0010585)2.37821730
65Abnormality of proline metabolism (HP:0010907)2.37628815
66Hydroxyprolinuria (HP:0003080)2.37628815
67Abnormal ossification of hand bones (HP:0005921)2.35594821
68Cholelithiasis (HP:0001081)2.35434168
69Gout (HP:0001997)2.35162372
70Abnormal gallbladder morphology (HP:0012437)2.34870405
71Amyloidosis (HP:0011034)2.32890579
72Malnutrition (HP:0004395)2.32694552
73Recurrent gram-negative bacterial infections (HP:0005420)2.31959351
74Asymmetry of the thorax (HP:0001555)2.29136995
75Abnormal tarsal ossification (HP:0008369)2.27428706
76Back pain (HP:0003418)2.25425215
77Thrombophlebitis (HP:0004418)2.21414199
78Abnormal gallbladder physiology (HP:0012438)2.19941702
79Cholecystitis (HP:0001082)2.19941702
80Menorrhagia (HP:0000132)2.14202548
81Dicarboxylic aciduria (HP:0003215)2.13044262
82Abnormality of dicarboxylic acid metabolism (HP:0010995)2.13044262
83Lethargy (HP:0001254)2.10460655
84Abnormal hand bone ossification (HP:0010660)2.09693520
85Hemorrhage of the eye (HP:0011885)2.09321056
86Sensorimotor neuropathy (HP:0007141)2.08613596
87Hyperglycemia (HP:0003074)2.04945522
88Neonatal onset (HP:0003623)2.04734498
89Abnormality of iron homeostasis (HP:0011031)2.04324064
90Hyperinsulinemic hypoglycemia (HP:0000825)2.04031513
91Abnormality of the acetabulum (HP:0003170)2.03571473
92Abnormality of transition element cation homeostasis (HP:0011030)2.02781194
93Nephritis (HP:0000123)2.02452780
94Late onset (HP:0003584)2.02033364
95Irritability (HP:0000737)2.01362730
96Abnormal cartilage morphology (HP:0002763)2.01202734
97Ulnar bowing (HP:0003031)2.00154777
98Increased serum pyruvate (HP:0003542)1.96743334
99Pancreatitis (HP:0001733)1.96061019
100Abnormality of glycolysis (HP:0004366)1.94218707
101Impaired pain sensation (HP:0007328)1.91089616
102Abnormality of pain sensation (HP:0010832)1.91089616
103Neonatal short-limb short stature (HP:0008921)1.90678765
104Peritonitis (HP:0002586)1.89630151
105Ankle contracture (HP:0006466)1.88278496
106Rickets (HP:0002748)1.87342365
107Enlarged kidneys (HP:0000105)1.87065875
108Biconcave vertebral bodies (HP:0004586)1.86136656
109Reticulocytosis (HP:0001923)1.85955215
110Wormian bones (HP:0002645)1.84612561
111Osteomalacia (HP:0002749)1.84489635
112Advanced eruption of teeth (HP:0006288)1.83362179
113Achilles tendon contracture (HP:0001771)1.83135768
114Abnormality of the Achilles tendon (HP:0005109)1.82948992
115Hypophosphatemic rickets (HP:0004912)1.82842258
116Abnormality of the gallbladder (HP:0005264)1.82484684
117Right ventricular cardiomyopathy (HP:0011663)1.81651118
118Abnormal foot bone ossification (HP:0010675)1.81561368
119Shallow orbits (HP:0000586)1.79951746
120Poikilocytosis (HP:0004447)1.79200959
121Protuberant abdomen (HP:0001538)1.78483606
122Opisthotonus (HP:0002179)1.78432333
123Blue sclerae (HP:0000592)1.77726180
124Abnormal enzyme/coenzyme activity (HP:0012379)1.77344173
125Stroke (HP:0001297)1.74737637
126Increased mean platelet volume (HP:0011877)1.74217085
127Renal duplication (HP:0000075)1.73247893
128Bronchomalacia (HP:0002780)1.71298161
129Arterial tortuosity (HP:0005116)1.69854903
130Vomiting (HP:0002013)1.69353041
131Alopecia of scalp (HP:0002293)1.69309955
132Cervical subluxation (HP:0003308)1.67648576
133Neonatal death (HP:0003811)1.65622263
134Pterygium (HP:0001059)1.65622248
135Vaginal fistula (HP:0004320)1.64377613
136Vascular tortuosity (HP:0004948)1.62969567
137Pancreatic islet-cell hyperplasia (HP:0004510)1.61575678
138Choanal stenosis (HP:0000452)1.59286288
139Aortic dissection (HP:0002647)1.58475461
140Coronal craniosynostosis (HP:0004440)1.56318027
141Cupped ribs (HP:0000887)1.55956664
142Abnormality of dentin (HP:0010299)1.54112258
143Coxa vara (HP:0002812)1.53383207
144Elevated alkaline phosphatase (HP:0003155)1.51596018
145Arnold-Chiari malformation (HP:0002308)1.50667521
146Abnormality of the lumbar spine (HP:0100712)1.50068661
147Cerebral aneurysm (HP:0004944)1.49813581
148Broad palm (HP:0001169)1.49306670

Predicted kinase interactions (KEA)

RankGene SetZ-score
1ERN14.66911118
2BCKDK4.54918469
3SIK14.36899837
4FGFR44.29623428
5PKN23.18270339
6TRIB32.99564518
7ERBB42.88213763
8LATS12.85971852
9EEF2K2.54460500
10SMG12.40221748
11INSRR2.36790546
12TAOK32.07097449
13PTK61.97768974
14MST1R1.90421266
15FRK1.79008879
16TYK21.74793648
17TTK1.71641381
18RIPK11.70276984
19EPHA21.68993417
20NEK91.62519306
21FLT31.62348846
22SCYL21.59081527
23EPHA31.58982731
24AKT31.56065404
25NEK11.55332371
26EPHB11.53525116
27JAK11.51775329
28MAPK111.51386288
29LMTK21.40608906
30PAK41.40377093
31PBK1.38415472
32NTRK11.37195754
33MAP3K31.36834882
34MAP3K71.32141021
35EIF2AK11.30909375
36TSSK61.30127235
37MAP3K141.28174692
38CAMK1D1.27344701
39MAP2K41.26891944
40PIK3CG1.22438654
41TBK11.15706532
42TTN1.15409624
43STK38L1.15343241
44JAK21.11492871
45DDR21.10200188
46PDGFRA1.08267774
47BMX1.06849607
48PRKAA21.03966220
49MAP2K31.03915881
50MET1.03853606
51WNK41.02554269
52MAP3K91.01779690
53FGFR31.00901686
54STK241.00433418
55ERBB20.97579715
56MAP3K100.97354177
57ABL20.97005377
58CDK70.96491179
59DAPK20.94118257
60CDK60.90951113
61PTK20.88550359
62TYRO30.88403525
63FGFR20.88030235
64MYLK0.86295004
65MELK0.82952422
66KSR20.82258910
67MTOR0.82228875
68SGK30.80697044
69BRSK20.77961786
70STK30.77774505
71MAP3K60.74236639
72PIK3CA0.73345321
73CDC42BPA0.73018648
74IRAK30.72228344
75MAP3K80.72180553
76GSK3A0.71965688
77LATS20.71586320
78CSK0.70854533
79CAMK1G0.68600063
80NEK20.68324947
81MAP3K20.67659629
82BRSK10.67468564
83EIF2AK30.67426675
84WNK10.66612974
85BUB10.66261211
86BRD40.65472390
87PRPF4B0.63761801
88SRPK10.63406351
89FER0.63095807
90ALK0.62491194
91RET0.60378978
92CDC70.59279940
93PLK30.58358140
94PRKAA10.58347106
95TGFBR20.57892668
96TAOK20.57558437
97MAP3K110.57409363
98KDR0.57248952
99MAP3K50.57022165
100GRK60.56619309
101FGFR10.54918304
102ARAF0.54424002
103PRKCZ0.54132656
104MAPK40.53021792
105CSNK1E0.52133977
106PRKACG0.51319076
107CDK40.49080228
108BRAF0.47162519
109CHUK0.46020889
110MAP3K130.46016842
111MAP3K10.46015926
112NME20.45175665
113MAPK120.44780548
114AKT20.43105609
115MAP2K10.43086565
116CDK80.42636038
117EGFR0.42225335
118PDPK10.41984326
119SGK20.41703424
120CDK90.41374302
121PDGFRB0.41351389
122JAK30.41092779
123DYRK1B0.40950672
124PDK40.40197977
125PDK30.40197977
126CDK120.39759207
127RPS6KB20.39251293
128CAMK2G0.39034241
129DMPK0.38774280
130IKBKE0.38674984
131STK380.38030691
132CHEK10.37772707
133PAK20.37508838
134ICK0.37289599
135IGF1R0.36699049
136TRPM70.35692593
137NLK0.35610292
138PDK20.33056853
139PAK30.32909427
140NUAK10.32527027
141STK390.32484157
142AURKB0.31578665
143ABL10.31558406
144CSF1R0.29780778
145MAPK70.29780206
146CAMK40.27397519
147PRKG20.22966263
148MAP2K20.22671994

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary bile acid biosynthesis_Homo sapiens_hsa001204.32076783
2Nitrogen metabolism_Homo sapiens_hsa009103.80899189
3Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004003.56943758
4Arginine biosynthesis_Homo sapiens_hsa002203.23734188
5Ascorbate and aldarate metabolism_Homo sapiens_hsa000533.22249056
6Complement and coagulation cascades_Homo sapiens_hsa046102.92403016
7Tryptophan metabolism_Homo sapiens_hsa003802.61505920
8Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010402.50950727
9Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006302.50154677
10Fatty acid degradation_Homo sapiens_hsa000712.50108670
11Glycine, serine and threonine metabolism_Homo sapiens_hsa002602.37834553
12Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.22086731
13Pentose and glucuronate interconversions_Homo sapiens_hsa000402.09668244
14Caffeine metabolism_Homo sapiens_hsa002322.05310061
15PPAR signaling pathway_Homo sapiens_hsa033202.00797738
16Staphylococcus aureus infection_Homo sapiens_hsa051501.96754510
17Peroxisome_Homo sapiens_hsa041461.92447339
18Butanoate metabolism_Homo sapiens_hsa006501.91687351
19Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.86305871
20Fatty acid metabolism_Homo sapiens_hsa012121.81984870
21Propanoate metabolism_Homo sapiens_hsa006401.78415273
22Chemical carcinogenesis_Homo sapiens_hsa052041.75217136
23Histidine metabolism_Homo sapiens_hsa003401.74170647
24Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.74049716
25Steroid hormone biosynthesis_Homo sapiens_hsa001401.71516097
262-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.68265174
27Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.65776445
28Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.65572515
29Selenocompound metabolism_Homo sapiens_hsa004501.64633114
30Drug metabolism - other enzymes_Homo sapiens_hsa009831.64439292
31Bile secretion_Homo sapiens_hsa049761.61894264
32beta-Alanine metabolism_Homo sapiens_hsa004101.57396530
33Retinol metabolism_Homo sapiens_hsa008301.51456647
34Fat digestion and absorption_Homo sapiens_hsa049751.45274039
35Phenylalanine metabolism_Homo sapiens_hsa003601.44493008
36Starch and sucrose metabolism_Homo sapiens_hsa005001.42886197
37Tyrosine metabolism_Homo sapiens_hsa003501.29144754
38Pyruvate metabolism_Homo sapiens_hsa006201.26441132
39Biosynthesis of amino acids_Homo sapiens_hsa012301.22795493
40Cysteine and methionine metabolism_Homo sapiens_hsa002701.21739569
41Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.19670838
42ABC transporters_Homo sapiens_hsa020101.19482664
43Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.17930458
44Carbon metabolism_Homo sapiens_hsa012001.15410042
45Folate biosynthesis_Homo sapiens_hsa007901.15226322
46Vitamin digestion and absorption_Homo sapiens_hsa049771.12400354
47Sulfur metabolism_Homo sapiens_hsa009201.09249241
48Steroid biosynthesis_Homo sapiens_hsa001001.04986992
49Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.01821470
50Lysine degradation_Homo sapiens_hsa003101.01300005
51Maturity onset diabetes of the young_Homo sapiens_hsa049500.97286959
52Fatty acid elongation_Homo sapiens_hsa000620.96799550
53Arginine and proline metabolism_Homo sapiens_hsa003300.95882161
54Cyanoamino acid metabolism_Homo sapiens_hsa004600.93227791
55One carbon pool by folate_Homo sapiens_hsa006700.85827270
56Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.85504450
57N-Glycan biosynthesis_Homo sapiens_hsa005100.83748585
58Other glycan degradation_Homo sapiens_hsa005110.83685004
59Fatty acid biosynthesis_Homo sapiens_hsa000610.78319622
60Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.76448483
61Sulfur relay system_Homo sapiens_hsa041220.75607702
62Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.72801567
63Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.69431410
64Glycerolipid metabolism_Homo sapiens_hsa005610.69255024
65Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.68360121
66Vitamin B6 metabolism_Homo sapiens_hsa007500.68033578
67Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.67205384
68Adherens junction_Homo sapiens_hsa045200.62292126
69Thyroid hormone synthesis_Homo sapiens_hsa049180.59032662
70Pentose phosphate pathway_Homo sapiens_hsa000300.55364269
71Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.55164280
72Glutathione metabolism_Homo sapiens_hsa004800.52400318
73Thyroid cancer_Homo sapiens_hsa052160.47440277
74Insulin resistance_Homo sapiens_hsa049310.46463259
75Adipocytokine signaling pathway_Homo sapiens_hsa049200.45473988
76Galactose metabolism_Homo sapiens_hsa000520.43649439
77Sphingolipid metabolism_Homo sapiens_hsa006000.42237149
78Focal adhesion_Homo sapiens_hsa045100.42188279
79Arachidonic acid metabolism_Homo sapiens_hsa005900.41505194
80Prion diseases_Homo sapiens_hsa050200.41066672
81Proteoglycans in cancer_Homo sapiens_hsa052050.40185424
82Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.34093717
83Fructose and mannose metabolism_Homo sapiens_hsa000510.33054921
84Metabolic pathways_Homo sapiens_hsa011000.32925927
85Small cell lung cancer_Homo sapiens_hsa052220.30848394
86TGF-beta signaling pathway_Homo sapiens_hsa043500.30217015
87Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.22686299
88Tight junction_Homo sapiens_hsa045300.20596989
89Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.20390030
90Glucagon signaling pathway_Homo sapiens_hsa049220.18325468
91alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.18185538
92AMPK signaling pathway_Homo sapiens_hsa041520.13882993
93Glycerophospholipid metabolism_Homo sapiens_hsa005640.10275690
94Central carbon metabolism in cancer_Homo sapiens_hsa052300.06355678
95Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.05733222
96Protein digestion and absorption_Homo sapiens_hsa049740.05189513
97Amoebiasis_Homo sapiens_hsa051460.04894970
98Linoleic acid metabolism_Homo sapiens_hsa005910.04855114
99Renin-angiotensin system_Homo sapiens_hsa046140.02245565
100Insulin signaling pathway_Homo sapiens_hsa049100.01250479
101Bladder cancer_Homo sapiens_hsa052190.01175612
102Longevity regulating pathway - mammal_Homo sapiens_hsa04211-0.1227751
103Pertussis_Homo sapiens_hsa05133-0.1195937
104Terpenoid backbone biosynthesis_Homo sapiens_hsa00900-0.1053967
105Legionellosis_Homo sapiens_hsa05134-0.1035365
106Type II diabetes mellitus_Homo sapiens_hsa04930-0.0981223
107African trypanosomiasis_Homo sapiens_hsa05143-0.0938412
108Glycosaminoglycan degradation_Homo sapiens_hsa00531-0.0930311
109Ovarian steroidogenesis_Homo sapiens_hsa04913-0.0902537
110Malaria_Homo sapiens_hsa05144-0.0829854
111Protein processing in endoplasmic reticulum_Homo sapiens_hsa04141-0.0733982
112ECM-receptor interaction_Homo sapiens_hsa04512-0.0615750
113Mineral absorption_Homo sapiens_hsa04978-0.0606785
114Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa00520-0.0526021
115Carbohydrate digestion and absorption_Homo sapiens_hsa04973-0.0362093
116Hepatitis C_Homo sapiens_hsa05160-0.0049006

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