SLC39A2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the ZIP family of metal ion transporters. The encoded protein functions as a zinc transporter. Mutations in this gene may be associated with susceptibility to carotid artery disease. Multiple transcript variants have been described. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1keratinocyte differentiation (GO:0030216)9.73491063
2acrosome assembly (GO:0001675)9.71259751
3keratinocyte proliferation (GO:0043616)8.57376007
4hair cycle (GO:0042633)8.21969825
5molting cycle (GO:0042303)8.21969825
6ribosomal small subunit assembly (GO:0000028)7.93521487
7epidermal cell differentiation (GO:0009913)7.92332403
8multicellular organismal water homeostasis (GO:0050891)7.87690230
9peptide cross-linking (GO:0018149)7.79836632
10bundle of His cell to Purkinje myocyte communication (GO:0086069)6.97665214
11genitalia morphogenesis (GO:0035112)6.61475804
12water homeostasis (GO:0030104)6.45848056
13epidermis development (GO:0008544)6.44480252
14short-term memory (GO:0007614)6.25702101
15viral transcription (GO:0019083)5.89509040
16gap junction assembly (GO:0016264)5.86810948
17protein heterotetramerization (GO:0051290)5.84352576
18ribosome assembly (GO:0042255)5.79165662
19long-chain fatty acid biosynthetic process (GO:0042759)5.72904208
20presynaptic membrane assembly (GO:0097105)5.67250542
21translational termination (GO:0006415)5.62058540
22cellular response to nitric oxide (GO:0071732)5.48553522
23keratinocyte development (GO:0003334)5.42347056
24intermediate filament organization (GO:0045109)5.36571407
25interkinetic nuclear migration (GO:0022027)5.27154342
26nucleobase-containing small molecule interconversion (GO:0015949)5.16913956
27SRP-dependent cotranslational protein targeting to membrane (GO:0006614)5.03855507
28cotranslational protein targeting to membrane (GO:0006613)5.02980979
29ribosomal small subunit biogenesis (GO:0042274)4.99750388
30lateral sprouting from an epithelium (GO:0060601)4.98240004
31protein targeting to ER (GO:0045047)4.96545313
32neuronal action potential propagation (GO:0019227)4.87444892
33linoleic acid metabolic process (GO:0043651)4.86405940
34establishment of tissue polarity (GO:0007164)4.80792721
35establishment of planar polarity (GO:0001736)4.80792721
36arginine catabolic process (GO:0006527)4.79927377
37phosphatidylinositol acyl-chain remodeling (GO:0036149)4.73602468
38protein localization to endoplasmic reticulum (GO:0070972)4.72485362
39fatty acid elongation (GO:0030497)4.69734166
40establishment of protein localization to endoplasmic reticulum (GO:0072599)4.67162660
41presynaptic membrane organization (GO:0097090)4.66169744
42translational elongation (GO:0006414)4.60464312
43translational initiation (GO:0006413)4.59152882
44lipoxygenase pathway (GO:0019372)4.53111625
45phosphatidylserine acyl-chain remodeling (GO:0036150)4.51536444
46cellular protein complex disassembly (GO:0043624)4.51259695
47epithelial cell differentiation involved in prostate gland development (GO:0060742)4.45831768
48deoxyribonucleoside diphosphate metabolic process (GO:0009186)4.38531099
49hair cell differentiation (GO:0035315)4.34389184
50negative regulation of keratinocyte proliferation (GO:0010839)4.33390510
51proteasome assembly (GO:0043248)4.32437981
52polarized epithelial cell differentiation (GO:0030859)4.30208873
53serine family amino acid biosynthetic process (GO:0009070)4.27981539
54detection of bacterium (GO:0016045)4.24769541
55cranial nerve morphogenesis (GO:0021602)4.21696945
56hair follicle morphogenesis (GO:0031069)4.19120427
57generation of neurons (GO:0048699)4.17842990
58positive regulation of dendritic spine morphogenesis (GO:0061003)4.17171780
59postsynaptic membrane organization (GO:0001941)4.16824318
60hemidesmosome assembly (GO:0031581)4.13723366
61GTP biosynthetic process (GO:0006183)4.12004307
62deoxyribonucleotide biosynthetic process (GO:0009263)4.08581931
63viral life cycle (GO:0019058)4.06666629
64nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)4.02811481
65apical protein localization (GO:0045176)3.99602731
66response to nitric oxide (GO:0071731)3.99438289
67regulation of cardioblast differentiation (GO:0051890)3.98975419
68phosphatidylglycerol acyl-chain remodeling (GO:0036148)3.95422266
69intermediate filament cytoskeleton organization (GO:0045104)3.93681632
70cell migration involved in heart development (GO:0060973)3.93228523
71skin morphogenesis (GO:0043589)3.91206003
72ribosomal large subunit biogenesis (GO:0042273)3.89553267
73protein complex disassembly (GO:0043241)3.89218048
74ectoderm development (GO:0007398)3.87673410
75intermediate filament-based process (GO:0045103)3.86905565
76translation (GO:0006412)3.79427275
77detection of other organism (GO:0098543)3.75267017
78sequestering of metal ion (GO:0051238)3.73490899
79positive regulation of insulin receptor signaling pathway (GO:0046628)3.69364768
80phosphatidylethanolamine acyl-chain remodeling (GO:0036152)3.66592318
81cellular response to reactive nitrogen species (GO:1902170)3.66426929
82macromolecular complex disassembly (GO:0032984)3.65152824
83regulation of T-helper 1 cell differentiation (GO:0045625)3.62506053
84facial nerve structural organization (GO:0021612)3.62348007
85cell surface receptor signaling pathway involved in heart development (GO:0061311)3.62173811
86positive regulation of oligodendrocyte differentiation (GO:0048714)3.61007266
87UTP biosynthetic process (GO:0006228)3.55363116
88eyelid development in camera-type eye (GO:0061029)3.53287703
89fucosylation (GO:0036065)3.52119567
90intestinal epithelial cell development (GO:0060576)3.52044247
91DNA ligation (GO:0006266)3.50073171
92positive regulation of actin filament depolymerization (GO:0030836)3.48977327
93regulation of T cell chemotaxis (GO:0010819)3.48615349
94positive regulation of T cell chemotaxis (GO:0010820)3.48615349
95CDP-diacylglycerol biosynthetic process (GO:0016024)3.47067561
96response to peptidoglycan (GO:0032494)3.45174828
97regulation of Wnt signaling pathway involved in heart development (GO:0003307)3.45110502
98negative regulation of T-helper cell differentiation (GO:0045623)3.40764980
99negative regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043371)3.40764980
100negative regulation of fibroblast growth factor receptor signaling pathway (GO:0040037)3.39609207
101regulation of keratinocyte proliferation (GO:0010837)3.38133961
102DNA damage response, detection of DNA damage (GO:0042769)3.37375260
103regulation of mitochondrial translation (GO:0070129)3.36956728
104CDP-diacylglycerol metabolic process (GO:0046341)3.34195193
105protein targeting to membrane (GO:0006612)3.33723731
106epithelium development (GO:0060429)3.33050058
107cytochrome complex assembly (GO:0017004)3.31174384
108sulfur amino acid catabolic process (GO:0000098)3.27625142
109phosphatidylcholine acyl-chain remodeling (GO:0036151)3.27251777
110cellular response to leptin stimulus (GO:0044320)3.25454071
111positive regulation of excitatory postsynaptic membrane potential (GO:2000463)3.23845793
112regulation of T-helper 2 cell differentiation (GO:0045628)3.23624674
113regulation of keratinocyte differentiation (GO:0045616)3.23333163
114DNA replication initiation (GO:0006270)3.21782092
115maturation of SSU-rRNA (GO:0030490)3.17323044
116DNA deamination (GO:0045006)3.16539931
117negative regulation of interferon-gamma production (GO:0032689)3.14607071
118regulation of pigment cell differentiation (GO:0050932)3.14262100
119myelin maintenance (GO:0043217)3.13847048
120positive regulation of dendritic spine development (GO:0060999)3.10018422
121negative regulation of phagocytosis (GO:0050765)3.07140724
122urea cycle (GO:0000050)3.07079357
123urea metabolic process (GO:0019627)3.07079357
124activation of adenylate cyclase activity (GO:0007190)3.05790295
125dendritic cell chemotaxis (GO:0002407)3.04081532
126protein neddylation (GO:0045116)3.03870127
127positive regulation of epidermis development (GO:0045684)3.00670711
128regulation of natural killer cell differentiation (GO:0032823)2.98995312
129melanin metabolic process (GO:0006582)2.97824215
130GMP metabolic process (GO:0046037)2.97544139
131hair cycle process (GO:0022405)2.95445207
132molting cycle process (GO:0022404)2.95445207
133phosphatidylserine metabolic process (GO:0006658)2.94819449
134positive regulation of membrane potential (GO:0045838)2.94452864
135respiratory chain complex IV assembly (GO:0008535)2.93609000
136negative regulation of epidermal cell differentiation (GO:0045605)2.93563148
137negative regulation of cell fate specification (GO:0009996)2.93545308
138cartilage morphogenesis (GO:0060536)2.92252322
139UTP metabolic process (GO:0046051)2.91004912
140spermatid nucleus differentiation (GO:0007289)2.90836561
141viral mRNA export from host cell nucleus (GO:0046784)2.90823114
142negative regulation of cardiac muscle cell apoptotic process (GO:0010667)2.90115376
143response to hyperoxia (GO:0055093)2.89639258
144response to increased oxygen levels (GO:0036296)2.89639258
145mesenchymal cell proliferation (GO:0010463)2.89042677
146negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)2.88758865
147regulation of axon regeneration (GO:0048679)2.84329133
148regulation of neuron projection regeneration (GO:0070570)2.84329133
149viral genome replication (GO:0019079)2.83865223
150regulation of interleukin-6 biosynthetic process (GO:0045408)2.83583019
151cardiac epithelial to mesenchymal transition (GO:0060317)2.83336085
152water-soluble vitamin biosynthetic process (GO:0042364)2.83195736
153labyrinthine layer development (GO:0060711)2.82923219
154nuclear-transcribed mRNA catabolic process (GO:0000956)2.82726623
155enteric nervous system development (GO:0048484)2.81055412
156mitochondrial calcium ion transport (GO:0006851)2.80867052
157axon ensheathment in central nervous system (GO:0032291)2.80347244
158central nervous system myelination (GO:0022010)2.80347244
159nitrogen cycle metabolic process (GO:0071941)2.80050894
160branching involved in prostate gland morphogenesis (GO:0060442)2.79806327
161negative regulation of T cell receptor signaling pathway (GO:0050860)2.79108216
162mRNA catabolic process (GO:0006402)2.78876441
163guanosine-containing compound biosynthetic process (GO:1901070)2.77757319
164positive regulation of protein kinase C signaling (GO:0090037)2.77736027
165telomere maintenance via semi-conservative replication (GO:0032201)2.77665192
166asymmetric protein localization (GO:0008105)2.77537522
167regulation of epidermis development (GO:0045682)2.76702685
168DNA replication checkpoint (GO:0000076)2.75690119
169regulation of branching involved in prostate gland morphogenesis (GO:0060687)2.74809821
170regulation of epidermal cell differentiation (GO:0045604)2.72749578
171regulation of glomerular filtration (GO:0003093)2.72219589
172planar cell polarity pathway involved in neural tube closure (GO:0090179)2.72214979
173actin filament depolymerization (GO:0030042)2.71562426
174positive regulation of epidermal cell differentiation (GO:0045606)2.70416955
175neurotransmitter catabolic process (GO:0042135)2.69338376
176behavioral response to ethanol (GO:0048149)2.67927903
177negative regulation of epidermis development (GO:0045683)2.67168711
178endothelium development (GO:0003158)2.62204096
179phospholipid efflux (GO:0033700)2.61887581
180regulation of transforming growth factor beta1 production (GO:0032908)2.60656466
181cranial suture morphogenesis (GO:0060363)2.57258644
182positive regulation of monocyte chemotaxis (GO:0090026)2.57050207
183regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)2.54554406
184surfactant homeostasis (GO:0043129)2.54230990
185phospholipase C-activating dopamine receptor signaling pathway (GO:0060158)2.53156856
186regulation of tight junction assembly (GO:2000810)2.52988391
187negative regulation of cell aging (GO:0090344)2.47548466
188atrioventricular valve morphogenesis (GO:0003181)2.47357520
189epithelial to mesenchymal transition involved in endocardial cushion formation (GO:0003198)2.43070318
190positive regulation of hair follicle development (GO:0051798)2.42391844
191positive regulation of hair cycle (GO:0042635)2.42391844
192negative regulation of stem cell proliferation (GO:2000647)2.41245284
193epithelial cell maturation (GO:0002070)2.40757955
194regulation of protein localization to cell surface (GO:2000008)2.38162893
195chondrocyte development (GO:0002063)2.37792625
196keratinization (GO:0031424)17.2083995
197establishment of skin barrier (GO:0061436)14.3505340
198desmosome organization (GO:0002934)12.5641713
199regulation of water loss via skin (GO:0033561)12.4303929

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human8.06885647
2SOX9_22984422_ChIP-ChIP_TESTIS_Rat6.19763962
3NOTCH1_17114293_ChIP-ChIP_T-ALL_Human4.97107166
4P63_26484246_Chip-Seq_KERATINOCYTES_Human3.99170572
5SMAD4_19686287_ChIP-ChIP_HaCaT_Human3.38927489
6KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.16544343
7HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.99503073
8ELK1_22589737_ChIP-Seq_MCF10A_Human2.77925208
9ELK1_19687146_ChIP-ChIP_HELA_Human2.72961632
10MYC_18555785_ChIP-Seq_MESCs_Mouse2.68401660
11SOX9_24532713_ChIP-Seq_HFSC_Mouse2.48753958
12CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.48310325
13HIF1A_21447827_ChIP-Seq_MCF-7_Human2.43415630
14ELF1_17652178_ChIP-ChIP_JURKAT_Human2.41593189
15ETS1_20019798_ChIP-Seq_JURKAT_Human2.40873669
16WT1_19549856_ChIP-ChIP_CCG9911_Human2.40236530
17GABP_17652178_ChIP-ChIP_JURKAT_Human2.34603760
18SMAD3_18955504_ChIP-ChIP_HaCaT_Human2.31774187
19SMAD2_18955504_ChIP-ChIP_HaCaT_Human2.31774187
20IRF1_19129219_ChIP-ChIP_H3396_Human2.30357408
21TP63_23658742_ChIP-Seq_EP156T_Human2.25398413
22EST1_17652178_ChIP-ChIP_JURKAT_Human2.22943652
23HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.17642198
24CREB1_15753290_ChIP-ChIP_HEK293T_Human2.11617314
25HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.09801702
26TP63_17297297_ChIP-ChIP_HaCaT_Human11.8288313
27MYB_21317192_ChIP-Seq_ERMYB_Mouse1.97337637
28MYC_18358816_ChIP-ChIP_MESCs_Mouse1.89343049
29CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.89061504
30TTF2_22483619_ChIP-Seq_HELA_Human1.87413032
31JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.87035296
32EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.84139623
33ZNF217_24962896_ChIP-Seq_MCF-7_Human1.83660290
34FLI1_27457419_Chip-Seq_LIVER_Mouse1.83608896
35ESR1_21235772_ChIP-Seq_MCF-7_Human1.78099869
36JARID2_20064375_ChIP-Seq_MESCs_Mouse1.75331337
37MYC_19030024_ChIP-ChIP_MESCs_Mouse1.74229695
38PCGF2_27294783_Chip-Seq_ESCs_Mouse1.70595704
39YY1_21170310_ChIP-Seq_MESCs_Mouse1.67487484
40KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.63891554
41E2F4_17652178_ChIP-ChIP_JURKAT_Human1.62900948
42XRN2_22483619_ChIP-Seq_HELA_Human1.60931129
43MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.59094412
44GATA4_25053715_ChIP-Seq_YYC3_Human1.53196398
45ESR1_20079471_ChIP-ChIP_T-47D_Human1.52349703
46TP53_18474530_ChIP-ChIP_U2OS_Human1.52081212
47FOXM1_26456572_ChIP-Seq_MCF-7_Human1.51826013
48CDX2_19796622_ChIP-Seq_MESCs_Mouse1.49921815
49NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.49278182
50NRF2_20460467_ChIP-Seq_MEFs_Mouse1.49278182
51HTT_18923047_ChIP-ChIP_STHdh_Human1.48969210
52FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.48745513
53GATA3_24758297_ChIP-Seq_MCF-7_Human1.48211905
54DCP1A_22483619_ChIP-Seq_HELA_Human1.47246211
55TCF4_18268006_ChIP-ChIP_LS174T_Human1.47193401
56CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.46771638
57ESR2_21235772_ChIP-Seq_MCF-7_Human1.45161962
58SOX2_20726797_ChIP-Seq_SW620_Human1.44877613
59FOXO3_23340844_ChIP-Seq_DLD1_Human1.44810159
60CJUN_26792858_Chip-Seq_BT549_Human1.37047800
61TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.35241986
62NFE2_27457419_Chip-Seq_LIVER_Mouse1.34676880
63VDR_21846776_ChIP-Seq_THP-1_Human1.33929016
64POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.31688624
65MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.30869860
66VDR_24763502_ChIP-Seq_THP-1_Human1.30421238
67CLOCK_20551151_ChIP-Seq_293T_Human1.29732049
68NELFA_20434984_ChIP-Seq_ESCs_Mouse1.29473755
69ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.28900628
70VDR_23849224_ChIP-Seq_CD4+_Human1.27036147
71ERG_20517297_ChIP-Seq_VCAP_Human1.25763018
72UBF1/2_26484160_Chip-Seq_HMECs_Human1.23834182
73SUZ12_27294783_Chip-Seq_NPCs_Mouse1.23498671
74TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.23228817
75TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.23054109
76GATA6_21074721_ChIP-Seq_CACO-2_Mouse1.22816880
77FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human1.22715688
78TP63_22573176_ChIP-Seq_HFKS_Human1.22444140
79BMI1_19503595_ChIP-Seq_MEFsC_Mouse1.22291714
80SOX9_26525672_Chip-Seq_Limbbuds_Mouse1.21494582
81MYC_18940864_ChIP-ChIP_HL60_Human1.21025692
82MYC_19079543_ChIP-ChIP_MESCs_Mouse1.20912198
83CDX2_20551321_ChIP-Seq_CACO-2_Human1.20033771
84NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.19690816
85HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.19652404
86JARID2_20075857_ChIP-Seq_MESCs_Mouse1.19127241
87SPI1_23547873_ChIP-Seq_NB4_Human1.17948401
88CTCF_27219007_Chip-Seq_ERYTHROID_Human1.17719855
89E2F1_18555785_ChIP-Seq_MESCs_Mouse1.16667116
90PIAS1_25552417_ChIP-Seq_VCAP_Human1.16511593
91PCGF2_27294783_Chip-Seq_NPCs_Mouse1.15287748
92SMAD3_21741376_ChIP-Seq_EPCs_Human1.14507141
93SMAD3_21741376_ChIP-Seq_HESCs_Human1.13436985
94SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.13149225
95AR_21572438_ChIP-Seq_LNCaP_Human1.12553546
96VDR_22108803_ChIP-Seq_LS180_Human1.11082120
97RXR_22108803_ChIP-Seq_LS180_Human1.10765849
98ZFP57_27257070_Chip-Seq_ESCs_Mouse1.10023863
99SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.09665056
100AR_21909140_ChIP-Seq_LNCAP_Human1.08873754
101GATA6_21074721_ChIP-Seq_CACO-2_Human1.08572111
102HOXB4_20404135_ChIP-ChIP_EML_Mouse1.08247924
103UTX_26944678_Chip-Seq_JUKART_Human1.07897251
104KLF5_25053715_ChIP-Seq_YYC3_Human1.07835084
105RNF2_18974828_ChIP-Seq_MESCs_Mouse1.07510208
106EZH2_18974828_ChIP-Seq_MESCs_Mouse1.07510208
107NANOG_16153702_ChIP-ChIP_HESCs_Human1.07114067
108IKZF1_21737484_ChIP-ChIP_HCT116_Human1.06618243
109TAF15_26573619_Chip-Seq_HEK293_Human1.04494301
110PPAR_26484153_Chip-Seq_NCI-H1993_Human1.04226266
111SREBP1_19666523_ChIP-Seq_LIVER_Mouse1.03472498
112TRIM28_21343339_ChIP-Seq_HEK293_Human1.03224747
113FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human1.02785026
114TCF4_22108803_ChIP-Seq_LS180_Human1.02596204
115FUS_26573619_Chip-Seq_HEK293_Human1.01976049
116TCF3_18692474_ChIP-Seq_MEFs_Mouse1.01706061
117SOX2_18692474_ChIP-Seq_MEFs_Mouse1.01312778
118NANOG_18358816_ChIP-ChIP_MESCs_Mouse1.01288278
119NACC1_18358816_ChIP-ChIP_MESCs_Mouse1.01251415
120CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.00896976
121E2F7_22180533_ChIP-Seq_HELA_Human1.00768097
122PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.00720848
123EZH2_27304074_Chip-Seq_ESCs_Mouse1.00177162
124VDR_24787735_ChIP-Seq_THP-1_Human1.00052349
125STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse0.99186971
126EOMES_21245162_ChIP-Seq_HESCs_Human0.98614341
127ZNF263_19887448_ChIP-Seq_K562_Human0.98309500
128TP53_20018659_ChIP-ChIP_R1E_Mouse0.97484061
129EED_16625203_ChIP-ChIP_MESCs_Mouse0.97145613
130KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human0.95564987
131LMO2_26923725_Chip-Seq_MACROPHAGESS_Mouse0.95297889
132KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human0.94232517
133P53_21459846_ChIP-Seq_SAOS-2_Human0.93809556
134GATA6_25053715_ChIP-Seq_YYC3_Human0.93231386
135AHR_22903824_ChIP-Seq_MCF-7_Human0.92766305
136AR_21915096_ChIP-Seq_LNCaP-1F5_Human0.91903661
137RUNX1_20887958_ChIP-Seq_HPC-7_Mouse0.91854376
138SOX2_27498859_Chip-Seq_STOMACH_Mouse0.91505306
139EGR1_19032775_ChIP-ChIP_M12_Human0.91336412
140AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.91177754
141RBPJ_21746931_ChIP-Seq_IB4_Human0.89928053
142TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.88585627
143FLI1_20887958_ChIP-Seq_HPC-7_Mouse0.88338870
144OCT4_18692474_ChIP-Seq_MEFs_Mouse0.86709814
145* MAF_26560356_Chip-Seq_TH2_Human0.86418855
146BMI1_23680149_ChIP-Seq_NPCS_Mouse0.86161111
147ARNT_22903824_ChIP-Seq_MCF-7_Human0.85946857
148RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse0.85806067
149ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.85219335
150MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human0.84277150
151CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.83738724
152POU5F1_16153702_ChIP-ChIP_HESCs_Human0.83432198
153CTBP2_25329375_ChIP-Seq_LNCAP_Human0.82217090
154RARG_19884340_ChIP-ChIP_MEFs_Mouse0.82183816
155SALL4_18804426_ChIP-ChIP_XEN_Mouse0.80772699
156SUZ12_18555785_Chip-Seq_ESCs_Mouse0.80080188
157POU5F1_26923725_Chip-Seq_MESODERM_Mouse0.79987833
158TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.79987833
159RUNX1_27457419_Chip-Seq_LIVER_Mouse0.79927215
160TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse0.79721928
161RUNX1_27514584_Chip-Seq_MCF-7_Human0.79208761
162SA1_27219007_Chip-Seq_ERYTHROID_Human0.78912476
163PKCTHETA_26484144_Chip-Seq_BREAST_Human0.78793708
164SOX2_18358816_ChIP-ChIP_MESCs_Mouse0.78789116
165CEBPD_23245923_ChIP-Seq_MEFs_Mouse0.77506680
166ETV2_25802403_ChIP-Seq_MESCs_Mouse0.77295457
167PU_27001747_Chip-Seq_BMDM_Mouse0.77041949
168AUTS2_25519132_ChIP-Seq_293T-REX_Human0.76634990
169EZH2_27294783_Chip-Seq_NPCs_Mouse0.76212255
170ZIC3_20872845_ChIP-ChIP_MESCs_Mouse0.76039252
171PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse0.75964595
172P300_19829295_ChIP-Seq_ESCs_Human0.75589694
173P53_22387025_ChIP-Seq_ESCs_Mouse0.75504618
174EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse0.75362868
175HNFA_21074721_ChIP-Seq_CACO-2_Human0.74539532
176BCAT_22108803_ChIP-Seq_LS180_Human0.74482234
177TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse0.73578079
178NANOG_18692474_ChIP-Seq_MEFs_Mouse0.73010331
179CDX2_22108803_ChIP-Seq_LS180_Human0.72521455
180AR_25329375_ChIP-Seq_VCAP_Human0.71715623
181ISL1_27105846_Chip-Seq_CPCs_Mouse0.71428166
182CDX2_21074721_ChIP-Seq_CACO-2_Mouse0.70338015
183FOXO1_23066095_ChIP-Seq_LIVER_Mouse0.69430983
184ELF5_23300383_ChIP-Seq_T47D_Human0.68893435

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002796_impaired_skin_barrier8.07774210
2MP0005275_abnormal_skin_tensile6.54576954
3MP0009379_abnormal_foot_pigmentation6.17568061
4MP0010234_abnormal_vibrissa_follicle5.82961284
5MP0003136_yellow_coat_color5.53864085
6MP0005409_darkened_coat_color4.83531367
7MP0005501_abnormal_skin_physiology4.50114073
8MP0003724_increased_susceptibility_to4.13381335
9MP0001188_hyperpigmentation3.98380305
10MP0003303_peritoneal_inflammation3.84909213
11MP0004381_abnormal_hair_follicle3.41841118
12MP0006054_spinal_hemorrhage3.11329730
13MP0001216_abnormal_epidermal_layer2.80940555
14MP0003453_abnormal_keratinocyte_physiol2.65315764
15MP0010678_abnormal_skin_adnexa2.61182765
16MP0003941_abnormal_skin_development2.59268632
17MP0002098_abnormal_vibrissa_morphology2.52085644
18MP0002166_altered_tumor_susceptibility2.51963276
19MP0003880_abnormal_central_pattern2.50667845
20MP0010771_integument_phenotype2.41332454
21MP0002009_preneoplasia2.41167368
22MP0002060_abnormal_skin_morphology2.38437607
23MP0005174_abnormal_tail_pigmentation2.36480857
24MP0000465_gastrointestinal_hemorrhage2.34889132
25MP0003315_abnormal_perineum_morphology2.33966453
26MP0000647_abnormal_sebaceous_gland2.24215857
27MP0006292_abnormal_olfactory_placode2.17932500
28MP0008260_abnormal_autophagy2.13582793
29MP0002006_tumorigenesis2.11546201
30MP0000383_abnormal_hair_follicle2.10693119
31MP0009053_abnormal_anal_canal2.10330577
32MP0000015_abnormal_ear_pigmentation2.08282634
33MP0000858_altered_metastatic_potential1.94446382
34MP0000377_abnormal_hair_follicle1.93996852
35MP0005084_abnormal_gallbladder_morpholo1.92334421
36MP0001919_abnormal_reproductive_system1.91556432
37MP0002139_abnormal_hepatobiliary_system1.91532046
38MP0010030_abnormal_orbit_morphology1.84539591
39MP0000537_abnormal_urethra_morphology1.81558128
40MP0002751_abnormal_autonomic_nervous1.79663455
41MP0000467_abnormal_esophagus_morphology1.79167724
42MP0003436_decreased_susceptibility_to1.77309822
43MP0001177_atelectasis1.75529712
44MP0003011_delayed_dark_adaptation1.75330795
45MP0004264_abnormal_extraembryonic_tissu1.71960602
46MP0004947_skin_inflammation1.67741699
47MP0003705_abnormal_hypodermis_morpholog1.66468229
48MP0003191_abnormal_cellular_cholesterol1.62400686
49MP0001968_abnormal_touch/_nociception1.51006595
50MP0003718_maternal_effect1.49790105
51MP0002160_abnormal_reproductive_system1.46147113
52MP0003693_abnormal_embryo_hatching1.45737760
53MP0001346_abnormal_lacrimal_gland1.44249250
54MP0002876_abnormal_thyroid_physiology1.42590680
55MP0002277_abnormal_respiratory_mucosa1.42443234
56MP0003890_abnormal_embryonic-extraembry1.41246424
57MP0004142_abnormal_muscle_tone1.40573643
58* MP0009931_abnormal_skin_appearance1.37356944
59MP0005389_reproductive_system_phenotype1.33527938
60MP0005377_hearing/vestibular/ear_phenot1.31310636
61MP0003878_abnormal_ear_physiology1.31310636
62MP0000681_abnormal_thyroid_gland1.30959928
63* MP0000367_abnormal_coat/_hair1.30835310
64MP0002177_abnormal_outer_ear1.29929000
65MP0004885_abnormal_endolymph1.26509165
66MP0005423_abnormal_somatic_nervous1.24171683
67MP0000427_abnormal_hair_cycle1.22046407
68MP0001191_abnormal_skin_condition1.20025567
69MP0003938_abnormal_ear_development1.17511880
70MP0009333_abnormal_splenocyte_physiolog1.15851306
71MP0001986_abnormal_taste_sensitivity1.14724449
72MP0001970_abnormal_pain_threshold1.14311345
73MP0006035_abnormal_mitochondrial_morpho1.13468485
74MP0008932_abnormal_embryonic_tissue1.07989888
75MP0002282_abnormal_trachea_morphology1.07013700
76MP0003566_abnormal_cell_adhesion1.05995655
77MP0005000_abnormal_immune_tolerance1.04275528
78MP0001533_abnormal_skeleton_physiology1.03427681
79MP0009745_abnormal_behavioral_response1.00461369
80MP0002064_seizures0.98724569
81MP0001485_abnormal_pinna_reflex0.97551075
82MP0002249_abnormal_larynx_morphology0.97475538
83MP0000920_abnormal_myelination0.97465488
84MP0010352_gastrointestinal_tract_polyps0.96396909
85MP0009384_cardiac_valve_regurgitation0.94880864
86MP0002272_abnormal_nervous_system0.94607078
87MP0002067_abnormal_sensory_capabilities0.94027132
88MP0002095_abnormal_skin_pigmentation0.93888717
89MP0005367_renal/urinary_system_phenotyp0.93435518
90MP0000516_abnormal_urinary_system0.93435518
91MP0005171_absent_coat_pigmentation0.91566269
92MP0005075_abnormal_melanosome_morpholog0.91405618
93MP0000049_abnormal_middle_ear0.91198378
94MP0008874_decreased_physiological_sensi0.90882261
95MP0000579_abnormal_nail_morphology0.90661973
96MP0002638_abnormal_pupillary_reflex0.90102656
97MP0005187_abnormal_penis_morphology0.90007280
98MP0003186_abnormal_redox_activity0.89827639
99MP0002332_abnormal_exercise_endurance0.89275031
100MP0001243_abnormal_dermal_layer0.86797304
101MP0003950_abnormal_plasma_membrane0.86084489
102MP0002971_abnormal_brown_adipose0.85117587
103MP0005464_abnormal_platelet_physiology0.84869970
104MP0002254_reproductive_system_inflammat0.83983676
105MP0005671_abnormal_response_to0.83660106
106MP0002822_catalepsy0.82979610
107MP0003279_aneurysm0.80764696
108MP0003635_abnormal_synaptic_transmissio0.80236470
109MP0002111_abnormal_tail_morphology0.79692356
110MP0003806_abnormal_nucleotide_metabolis0.78511714
111MP0004270_analgesia0.78153698
112MP0004742_abnormal_vestibular_system0.77588827
113MP0001784_abnormal_fluid_regulation0.77464939
114MP0005025_abnormal_response_to0.77354126
115MP0008438_abnormal_cutaneous_collagen0.76877904
116MP0003567_abnormal_fetal_cardiomyocyte0.76452126
117MP0009046_muscle_twitch0.75280449
118MP0000762_abnormal_tongue_morphology0.74619646
119MP0001944_abnormal_pancreas_morphology0.74274105
120MP0002419_abnormal_innate_immunity0.72774616
121MP0000372_irregular_coat_pigmentation0.72699100
122MP0003937_abnormal_limbs/digits/tail_de0.72376951
123MP0000566_synostosis0.70751707
124MP0001905_abnormal_dopamine_level0.70661446
125MP0003111_abnormal_nucleus_morphology0.70380262
126MP0009250_abnormal_appendicular_skeleto0.70121255
127MP0005248_abnormal_Harderian_gland0.69350262
128MP0004272_abnormal_basement_membrane0.68867146
129MP0004859_abnormal_synaptic_plasticity0.68020364
130MP0001984_abnormal_olfaction0.67468533
131MP0002148_abnormal_hypersensitivity_rea0.65365387
132MP0003755_abnormal_palate_morphology0.65124250
133MP0008469_abnormal_protein_level0.64231277
134MP0009697_abnormal_copulation0.64105740
135MP0005408_hypopigmentation0.63728757
136MP0001486_abnormal_startle_reflex0.62090843
137MP0002133_abnormal_respiratory_system0.61528041
138MP0005388_respiratory_system_phenotype0.61528041
139MP0005397_hematopoietic_system_phenotyp0.61193467
140MP0001545_abnormal_hematopoietic_system0.61193467
141MP0005332_abnormal_amino_acid0.61078778
142MP0005197_abnormal_uvea_morphology0.60455610
143MP0001963_abnormal_hearing_physiology0.60398947
144MP0001851_eye_inflammation0.59716482
145MP0005508_abnormal_skeleton_morphology0.58152970
146MP0004957_abnormal_blastocyst_morpholog0.57840721
147MP0000613_abnormal_salivary_gland0.57187640
148MP0002736_abnormal_nociception_after0.56235948
149MP0005023_abnormal_wound_healing0.55746731
150MP0002938_white_spotting0.55328048
151MP0000778_abnormal_nervous_system0.54467566
152MP0001663_abnormal_digestive_system0.54113358
153MP0000462_abnormal_digestive_system0.53884290
154MP0001340_abnormal_eyelid_morphology0.53504543
155MP0005394_taste/olfaction_phenotype0.53358884
156MP0005499_abnormal_olfactory_system0.53358884
157MP0000026_abnormal_inner_ear0.53348095
158MP0009785_altered_susceptibility_to0.52084122
159MP0002234_abnormal_pharynx_morphology0.51709262
160MP0005503_abnormal_tendon_morphology0.51331567
161MP0002693_abnormal_pancreas_physiology0.51072147
162MP0004782_abnormal_surfactant_physiolog0.48915271
163MP0003786_premature_aging0.48328477
164MP0002735_abnormal_chemical_nociception0.48306837
165MP0003385_abnormal_body_wall0.48086205
166MP0002734_abnormal_mechanical_nocicepti0.47886130
167MP0005193_abnormal_anterior_eye0.46284837
168MP0001186_pigmentation_phenotype0.45742711
169MP0002109_abnormal_limb_morphology0.45469600
170MP0002233_abnormal_nose_morphology0.44285721
171MP0000432_abnormal_head_morphology0.44047523
172MP0008789_abnormal_olfactory_epithelium0.43539199
173MP0001915_intracranial_hemorrhage0.42026504
174MP0005257_abnormal_intraocular_pressure0.42017140
175MP0002697_abnormal_eye_size0.41447569
176MP0000371_diluted_coat_color0.40547961

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of nail color (HP:0100643)8.52646322
2Erythroderma (HP:0001019)7.41741226
3Palmoplantar hyperkeratosis (HP:0000972)7.35343315
4Palmar hyperkeratosis (HP:0010765)7.11958445
5Increased IgE level (HP:0003212)6.84935589
6Hypotrichosis (HP:0001006)6.13243958
7Plantar hyperkeratosis (HP:0007556)6.05970867
8Onycholysis (HP:0001806)5.72282132
9Alopecia of scalp (HP:0002293)5.63941994
10Erythema (HP:0010783)5.25644451
11Conjunctival hamartoma (HP:0100780)5.24523020
12Oral leukoplakia (HP:0002745)5.00967729
13Parakeratosis (HP:0001036)4.97163676
14Thick nail (HP:0001805)4.92598044
15Type I transferrin isoform profile (HP:0003642)4.88524570
16Reduced antithrombin III activity (HP:0001976)4.68001032
17Woolly hair (HP:0002224)4.44756637
18Focal motor seizures (HP:0011153)4.43552252
19Dry hair (HP:0011359)4.42343840
20Corneal erosion (HP:0200020)4.36356208
21Right ventricular cardiomyopathy (HP:0011663)4.16886025
22Abnormality of cells of the erythroid lineage (HP:0012130)3.99106245
23Menorrhagia (HP:0000132)3.90750827
24Abnormality of pyrimidine metabolism (HP:0004353)3.89577594
25Absent eyelashes (HP:0000561)3.85357241
26Fragile nails (HP:0001808)3.76887840
27Stomatitis (HP:0010280)3.70535868
28Aplasia/Hypoplasia of the sacrum (HP:0008517)3.69479422
29Chronic obstructive pulmonary disease (HP:0006510)3.66221415
30Obstructive lung disease (HP:0006536)3.66221415
31Palmoplantar keratoderma (HP:0000982)3.66041677
32Abnormality of monocarboxylic acid metabolism (HP:0010996)3.62338726
33Sparse eyelashes (HP:0000653)3.61401578
34Abnormality of the axillary hair (HP:0100134)3.58811331
35Abnormality of secondary sexual hair (HP:0009888)3.58811331
36Absent hair (HP:0002298)3.40270254
37Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)3.40269891
38Hamartoma of the eye (HP:0010568)3.33145064
39Hypohidrosis (HP:0000966)3.32699082
40Nail dystrophy (HP:0008404)3.28921614
41Chronic mucocutaneous candidiasis (HP:0002728)3.27219875
42Recurrent cutaneous fungal infections (HP:0011370)3.27219875
43Mediastinal lymphadenopathy (HP:0100721)3.22389132
44Macrocytic anemia (HP:0001972)3.20321586
45Selective tooth agenesis (HP:0001592)3.18581634
46Abnormal number of erythroid precursors (HP:0012131)3.14185205
47Sex reversal (HP:0012245)3.13520940
48Abnormal sex determination (HP:0012244)3.13520940
49Hypoplastic labia majora (HP:0000059)3.11324258
50Lip pit (HP:0100267)3.09550459
51Congenital nonbullous ichthyosiform erythroderma (HP:0007479)3.08456158
52Abnormality of placental membranes (HP:0011409)3.02389768
53Amniotic constriction ring (HP:0009775)3.02389768
54Abnormal hair laboratory examination (HP:0003328)3.02372289
55Ectropion (HP:0000656)2.98550411
56Short middle phalanx of the 5th finger (HP:0004220)2.97277042
57Pili torti (HP:0003777)2.93801089
58Gangrene (HP:0100758)2.92890313
59Obstructive sleep apnea (HP:0002870)2.84396199
60Abnormality of the labia majora (HP:0012881)2.83642685
61Joint hemorrhage (HP:0005261)2.83375515
62Capillary hemangiomas (HP:0005306)2.77746917
63Cheilitis (HP:0100825)2.76674251
64Meningitis (HP:0001287)2.72506150
65Eczematoid dermatitis (HP:0000976)2.72468708
66Abnormality of the salivary glands (HP:0010286)2.71513720
67Patent foramen ovale (HP:0001655)2.70074277
68Abnormal blistering of the skin (HP:0008066)2.65749287
69Increased mean platelet volume (HP:0011877)2.57852112
70Coronal craniosynostosis (HP:0004440)2.55318852
71Abnormal protein glycosylation (HP:0012346)2.53969063
72Abnormal glycosylation (HP:0012345)2.53969063
73Abnormal isoelectric focusing of serum transferrin (HP:0003160)2.53969063
74Abnormal protein N-linked glycosylation (HP:0012347)2.53969063
75Muscle abnormality related to mitochondrial dysfunction (HP:0003800)2.53640317
76Sparse scalp hair (HP:0002209)2.53492683
77Absent rod-and cone-mediated responses on ERG (HP:0007688)2.53347373
78Prolonged partial thromboplastin time (HP:0003645)2.50165152
79Thoracic kyphosis (HP:0002942)2.48477127
80Split foot (HP:0001839)2.47765861
81Furrowed tongue (HP:0000221)2.43333245
82Sleep apnea (HP:0010535)2.43169199
83Myocardial infarction (HP:0001658)2.42717599
84Abnormal platelet volume (HP:0011876)2.42054156
85Aplasia involving bones of the upper limbs (HP:0009823)2.41051439
86Aplasia of the phalanges of the hand (HP:0009802)2.41051439
87Aplasia involving bones of the extremities (HP:0009825)2.41051439
88Severe visual impairment (HP:0001141)2.39702847
89Aplastic anemia (HP:0001915)2.39658834
90Abnormality of glutamine family amino acid metabolism (HP:0010902)2.39589892
91Blepharitis (HP:0000498)2.38128297
92Slow-growing hair (HP:0002217)2.37803801
93Abnormality of hair growth rate (HP:0011363)2.37803801
94Septate vagina (HP:0001153)2.37208276
95Reticulocytopenia (HP:0001896)2.35975719
96Supernumerary spleens (HP:0009799)2.35682369
97Seborrheic dermatitis (HP:0001051)2.31706718
98Recurrent abscess formation (HP:0002722)2.30419615
99Follicular hyperkeratosis (HP:0007502)2.26681725
100Attenuation of retinal blood vessels (HP:0007843)2.25669234
101Brittle hair (HP:0002299)2.25637313
102Recurrent gram-negative bacterial infections (HP:0005420)2.24175712
103Increased hepatocellular lipid droplets (HP:0006565)2.24164208
104Bilateral sensorineural hearing impairment (HP:0008619)2.20771376
105Abnormality of the dental root (HP:0006486)2.20625396
106Taurodontia (HP:0000679)2.20625396
107Abnormality of permanent molar morphology (HP:0011071)2.20625396
108Congenital malformation of the right heart (HP:0011723)2.20620501
109Double outlet right ventricle (HP:0001719)2.20620501
110Aplasia/Hypoplasia of the middle phalanx of the 5th finger (HP:0009161)2.18738168
111Alkalosis (HP:0001948)2.17777202
112Renal Fanconi syndrome (HP:0001994)2.14141902
113Cerebral edema (HP:0002181)2.11036018
114Natal tooth (HP:0000695)2.09713112
115Congenital ichthyosiform erythroderma (HP:0007431)2.09101189
116Abnormality of molar morphology (HP:0011070)2.09050452
117Abnormality of molar (HP:0011077)2.09050452
118Optic disc pallor (HP:0000543)2.08059925
119Milia (HP:0001056)2.06282045
120Recurrent skin infections (HP:0001581)2.05242890
121Duplicated collecting system (HP:0000081)2.05074927
122Late onset (HP:0003584)2.04736595
123Abnormality of magnesium homeostasis (HP:0004921)2.04674354
124Pruritus (HP:0000989)2.03497588
125Microcytic anemia (HP:0001935)2.01135296
126Nasolacrimal duct obstruction (HP:0000579)1.98818350
127Abnormality of serum amino acid levels (HP:0003112)1.98397366
128Vacuolated lymphocytes (HP:0001922)1.98146225
129Prolonged bleeding time (HP:0003010)1.97998741
130Aplasia/Hypoplasia of the phalanges of the 5th finger (HP:0009376)1.97141384
131Hyperglycinemia (HP:0002154)1.97014292
132Hamartoma (HP:0010566)1.96435886
133Decreased central vision (HP:0007663)1.95345132
134Pallor (HP:0000980)1.95216198
135Autoamputation (HP:0001218)1.95042698
136Abnormality of the dental pulp (HP:0006479)1.93934032
137Nephritis (HP:0000123)1.91461361
138Testicular atrophy (HP:0000029)1.91270231
139Melanocytic nevus (HP:0000995)1.90201757
140Concave nail (HP:0001598)1.90110249
141Hyperthyroidism (HP:0000836)1.89133117
142Advanced eruption of teeth (HP:0006288)1.87464852
143Hepatocellular necrosis (HP:0001404)1.86114228
144Esotropia (HP:0000565)1.85789578
145Exertional dyspnea (HP:0002875)1.85448313
146Lack of skin elasticity (HP:0100679)1.84323934
147Short hallux (HP:0010109)1.83615614
148Lipid accumulation in hepatocytes (HP:0006561)1.82788889
149Mitochondrial inheritance (HP:0001427)1.82716814
150Hyperparathyroidism (HP:0000843)1.79584057
151Abnormal activity of mitochondrial respiratory chain (HP:0011922)1.78902046
152Decreased activity of mitochondrial respiratory chain (HP:0008972)1.78902046
153Abnormality of the lacrimal duct (HP:0011481)1.78115068
154Epistaxis (HP:0000421)1.77619855
155Labial hypoplasia (HP:0000066)1.77305891
156Hydroureter (HP:0000072)1.75934924
157Abnormality of the middle phalanx of the 5th finger (HP:0004219)1.75145999
158Myokymia (HP:0002411)1.74675945
159Aplasia/Hypoplasia of the phalanges of the toes (HP:0010173)1.74046497
160Abnormality of the labia minora (HP:0012880)1.74008893
161Abnormality of the septum pellucidum (HP:0007375)1.73740640
162Abnormality of the renal collecting system (HP:0004742)1.73707763
163Hypoplasia of the radius (HP:0002984)1.72899810
164Abnormality of the nasolacrimal system (HP:0000614)1.72512252
165Osteomyelitis (HP:0002754)1.72420126
166Papilledema (HP:0001085)1.71993648
167Verrucae (HP:0200043)1.71454097
168Papilloma (HP:0012740)1.71454097
169Agammaglobulinemia (HP:0004432)1.71406174
170Abnormality of dental color (HP:0011073)1.70196413
171Pustule (HP:0200039)1.69239729
172Long nose (HP:0003189)1.67320804
173Ankyloglossia (HP:0010296)1.66842210
174Ventricular tachycardia (HP:0004756)1.66166646
175Pancytopenia (HP:0001876)1.65638950
176Neonatal death (HP:0003811)1.65587539
177Aplasia/Hypoplasia of the ulna (HP:0006495)1.65232565
178Hypercortisolism (HP:0001578)1.64900669
179Skin rash (HP:0000988)1.64117085
180Short 5th finger (HP:0009237)1.61355382
181Ridged nail (HP:0001807)1.60606805
182Congenital, generalized hypertrichosis (HP:0004540)1.60570793
183Abnormality of the phalanges of the 5th finger (HP:0004213)1.59748196
184Recurrent corneal erosions (HP:0000495)1.58986320
185Hyperhidrosis (HP:0000975)1.58536100
186Aplasia/Hypoplasia of the hallux (HP:0008362)1.58302095
187Hypoplastic female external genitalia (HP:0012815)1.57556174
188Anonychia (HP:0001798)1.54613786
189Depressed nasal tip (HP:0000437)1.54071430
190Anhidrosis (HP:0000970)1.53497474
191Myelomeningocele (HP:0002475)1.52866792

Predicted kinase interactions (KEA)

RankGene SetZ-score
1EIF2AK38.62793485
2TESK25.76487345
3TGFBR14.50940551
4STK244.04856976
5MKNK23.74786461
6CASK3.53115092
7TESK13.39931093
8PDK23.21301158
9TLK12.99152583
10PLK42.96904215
11EIF2AK22.87357287
12MAPKAPK32.77592831
13GRK62.74075796
14EPHA22.72073476
15LIMK12.62921849
16MKNK12.60043016
17LRRK22.55987597
18ACVR1B2.50617441
19FGFR12.45737194
20NLK2.30313329
21NME22.19341389
22WEE12.15672652
23LATS12.01266215
24TNIK1.90807076
25TRPM71.84476093
26BMPR1B1.78046226
27PAK41.73023843
28MAP3K61.70729440
29FES1.63676012
30MAP3K21.59139658
31MAP3K121.55272201
32PLK21.50058020
33MAPK71.49627274
34CLK11.47167221
35AKT31.37167299
36MAP3K31.33220762
37ADRBK11.32939408
38UHMK11.31913830
39PIM21.30440576
40NUAK11.28003185
41YES11.27004917
42DMPK1.26283876
43EEF2K1.23291845
44STK31.22198514
45STK161.18354990
46KDR1.14611961
47TIE11.12830240
48PIM11.07579099
49MAP3K91.06968956
50EPHB21.04704463
51CSNK1G10.99955400
52FGFR20.93477100
53MET0.92126925
54MAP2K70.91610634
55ROCK20.90184145
56RPS6KB20.89516192
57MAPK120.88797449
58IRAK40.88449477
59MAP3K80.87343965
60BRD40.87181461
61TRIM280.86353304
62PIK3CG0.82605925
63ARAF0.82408292
64ROCK10.81511121
65FLT30.80743692
66PRKD20.80302313
67TAF10.79597984
68CDK190.79404339
69PRPF4B0.78874030
70MST1R0.77695262
71LATS20.76417703
72SCYL20.75648267
73SRPK10.73295505
74NEK10.71506475
75MAPK40.71159763
76VRK10.70624197
77PRKD30.69708255
78FRK0.69441180
79STK38L0.69331505
80NME10.68067389
81ZAP700.68006002
82CAMKK20.67954563
83PRKCE0.67629409
84ILK0.66756435
85ERBB30.66158393
86GRK70.62450139
87PDGFRA0.62273185
88HIPK20.61758217
89DYRK1A0.61571007
90MATK0.61370394
91PHKG10.61111605
92PHKG20.61111605
93KIT0.58045083
94MAP3K110.57324237
95MST40.56506500
96FGFR30.56267877
97TEC0.56201245
98PAK10.55249251
99MINK10.54688648
100BRAF0.52481404
101TGFBR20.51233431
102CDK60.49809100
103PRKAA20.46895498
104FER0.46834297
105NTRK30.46753943
106DDR20.46683500
107CAMK40.45915714
108CSNK1A1L0.45656821
109ABL20.45271730
110RPS6KL10.45242788
111RPS6KC10.45242788
112MAP3K10.43988278
113CDK30.43951281
114DYRK20.43784190
115STK380.43084521
116SYK0.42943633
117GRK50.42207033
118ERBB20.40166159
119RIPK40.39691127
120JAK20.39432401
121BRSK20.38824524
122CAMK2B0.37917348
123MUSK0.36545968
124MAPKAPK50.36322752
125DAPK30.36219356
126AURKA0.36070613
127IRAK20.36054177
128BUB10.35393583
129MYLK0.34200981
130BLK0.33341427
131PTK60.32249925
132RPS6KA60.31580717
133SGK20.31278908
134NEK20.31088338
135RPS6KA50.30956306
136AKT20.30511179
137SIK30.29614523
138CSNK1G20.29448981
139SGK4940.29101889
140SGK2230.29101889
141STK100.27996665
142CSNK2A10.27912287
143TAOK30.27821902
144IGF1R0.27249934
145JAK10.26583540
146NEK90.25451660
147DYRK1B0.25253851
148CDK40.24930465
149PRKCQ0.24430433
150PRKD10.24242907
151IRAK30.23907332
152STK110.22668308
153PRKCD0.21646711
154MELK0.19975420
155EIF2AK10.19257014
156CAMK10.19127407
157ZAK0.18167417
158CAMK2A0.17686182
159CAMK2G0.17633707
160EPHA40.17087565
161CSNK1G30.15894659
162PBK0.15755457
163LYN0.15674101
164CDK70.14916792
165BCR0.14204836
166CDK140.13696009
167IRAK10.13586531
168CDK180.13406783
169CDC70.12306198

Predicted pathways (KEGG)

RankGene SetZ-score
1Ribosome_Homo sapiens_hsa030106.78076897
2alpha-Linolenic acid metabolism_Homo sapiens_hsa005925.32897806
3Linoleic acid metabolism_Homo sapiens_hsa005914.22884860
4DNA replication_Homo sapiens_hsa030302.88840980
5Selenocompound metabolism_Homo sapiens_hsa004502.75246827
6Spliceosome_Homo sapiens_hsa030402.69027342
7Protein export_Homo sapiens_hsa030602.68090714
8Proteasome_Homo sapiens_hsa030502.66091470
9Oxidative phosphorylation_Homo sapiens_hsa001902.61676858
10Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005332.57705977
11Arginine biosynthesis_Homo sapiens_hsa002202.32682052
12RNA polymerase_Homo sapiens_hsa030202.20259860
13Pyrimidine metabolism_Homo sapiens_hsa002402.06377745
14Homologous recombination_Homo sapiens_hsa034401.91779552
15Alzheimers disease_Homo sapiens_hsa050101.89178478
16Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.81464881
17p53 signaling pathway_Homo sapiens_hsa041151.78820311
18Parkinsons disease_Homo sapiens_hsa050121.74493622
19Phototransduction_Homo sapiens_hsa047441.69472896
20Glutathione metabolism_Homo sapiens_hsa004801.66727914
21Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.61868833
22Sphingolipid metabolism_Homo sapiens_hsa006001.57380231
23Basal cell carcinoma_Homo sapiens_hsa052171.55424435
24Adherens junction_Homo sapiens_hsa045201.55176671
25Steroid biosynthesis_Homo sapiens_hsa001001.49614080
26Huntingtons disease_Homo sapiens_hsa050161.48893214
27Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.47674194
28Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.46346718
29Pentose phosphate pathway_Homo sapiens_hsa000301.43146136
30Vitamin B6 metabolism_Homo sapiens_hsa007501.39520421
31Nicotine addiction_Homo sapiens_hsa050331.38477887
32Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.38474348
33Steroid hormone biosynthesis_Homo sapiens_hsa001401.37882868
34Other glycan degradation_Homo sapiens_hsa005111.34618573
35Hedgehog signaling pathway_Homo sapiens_hsa043401.31715341
36Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.29788054
37Pentose and glucuronate interconversions_Homo sapiens_hsa000401.27102973
38TGF-beta signaling pathway_Homo sapiens_hsa043501.26149318
39Ovarian steroidogenesis_Homo sapiens_hsa049131.23763934
40Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.19504202
41Phenylalanine metabolism_Homo sapiens_hsa003601.16745645
42Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.15364071
43ECM-receptor interaction_Homo sapiens_hsa045121.14410328
44Amoebiasis_Homo sapiens_hsa051461.14076554
45Vascular smooth muscle contraction_Homo sapiens_hsa042701.09903240
46Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.08821790
47Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.08191172
48Basal transcription factors_Homo sapiens_hsa030221.04277102
49GnRH signaling pathway_Homo sapiens_hsa049121.02528044
50Hippo signaling pathway_Homo sapiens_hsa043901.01360884
51Serotonergic synapse_Homo sapiens_hsa047261.00912537
52Leishmaniasis_Homo sapiens_hsa051401.00603369
53Purine metabolism_Homo sapiens_hsa002300.97621468
54Circadian rhythm_Homo sapiens_hsa047100.97543909
55Fat digestion and absorption_Homo sapiens_hsa049750.96537341
56Fatty acid degradation_Homo sapiens_hsa000710.96325534
57Fatty acid elongation_Homo sapiens_hsa000620.94096125
58Vibrio cholerae infection_Homo sapiens_hsa051100.93965410
59Mismatch repair_Homo sapiens_hsa034300.92419133
60Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.92247543
61Sulfur relay system_Homo sapiens_hsa041220.89057794
62Nucleotide excision repair_Homo sapiens_hsa034200.88301737
63Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.87358235
64RNA transport_Homo sapiens_hsa030130.86591682
65Tyrosine metabolism_Homo sapiens_hsa003500.86019573
66Fanconi anemia pathway_Homo sapiens_hsa034600.85752429
67Folate biosynthesis_Homo sapiens_hsa007900.84451332
68Mineral absorption_Homo sapiens_hsa049780.83877621
69Maturity onset diabetes of the young_Homo sapiens_hsa049500.83749334
70Glutamatergic synapse_Homo sapiens_hsa047240.83432287
71Histidine metabolism_Homo sapiens_hsa003400.83400659
72Chemical carcinogenesis_Homo sapiens_hsa052040.81256727
73Prostate cancer_Homo sapiens_hsa052150.79245776
74Base excision repair_Homo sapiens_hsa034100.77696293
75One carbon pool by folate_Homo sapiens_hsa006700.77447824
76Regulation of autophagy_Homo sapiens_hsa041400.76843233
77VEGF signaling pathway_Homo sapiens_hsa043700.73237612
78Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.73186320
79Pyruvate metabolism_Homo sapiens_hsa006200.72768867
80Renin secretion_Homo sapiens_hsa049240.71414443
81Tight junction_Homo sapiens_hsa045300.70241132
82Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.67844494
83Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.67684269
84Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.67398607
85Salmonella infection_Homo sapiens_hsa051320.65927897
86Ras signaling pathway_Homo sapiens_hsa040140.65778732
87Pertussis_Homo sapiens_hsa051330.65316689
88Staphylococcus aureus infection_Homo sapiens_hsa051500.64965029
89Ether lipid metabolism_Homo sapiens_hsa005650.64541139
90Renin-angiotensin system_Homo sapiens_hsa046140.64465448
91Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.64328600
92Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.63373428
93Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.63046671
94Arachidonic acid metabolism_Homo sapiens_hsa005900.62266882
95Protein digestion and absorption_Homo sapiens_hsa049740.62216118
96Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.62001284
97Fatty acid biosynthesis_Homo sapiens_hsa000610.61962563
98Transcriptional misregulation in cancer_Homo sapiens_hsa052020.61941804
99ABC transporters_Homo sapiens_hsa020100.61536541
100Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.60939299
1012-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.59741429
102Sulfur metabolism_Homo sapiens_hsa009200.59327102
103Metabolic pathways_Homo sapiens_hsa011000.58344115
104Proteoglycans in cancer_Homo sapiens_hsa052050.58300195
105Intestinal immune network for IgA production_Homo sapiens_hsa046720.58032081
106Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.56355625
107Wnt signaling pathway_Homo sapiens_hsa043100.56294935
108Tuberculosis_Homo sapiens_hsa051520.55724820
109Vitamin digestion and absorption_Homo sapiens_hsa049770.53925661
110Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.53676338
111Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.53470181
112Prion diseases_Homo sapiens_hsa050200.52076881
113Long-term depression_Homo sapiens_hsa047300.51691229
114Morphine addiction_Homo sapiens_hsa050320.51096165
115Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.50789186
116Cyanoamino acid metabolism_Homo sapiens_hsa004600.50282527
117Complement and coagulation cascades_Homo sapiens_hsa046100.50144967
118Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.49321908
119Phosphatidylinositol signaling system_Homo sapiens_hsa040700.49119628
120Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.47299489
121Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.46839756
122beta-Alanine metabolism_Homo sapiens_hsa004100.45469298
123Collecting duct acid secretion_Homo sapiens_hsa049660.45195911
124Cardiac muscle contraction_Homo sapiens_hsa042600.44978875
125GABAergic synapse_Homo sapiens_hsa047270.43974945
126Amphetamine addiction_Homo sapiens_hsa050310.43868467
127Platelet activation_Homo sapiens_hsa046110.43181291
128Cell cycle_Homo sapiens_hsa041100.43075855
129Primary bile acid biosynthesis_Homo sapiens_hsa001200.42734407
130PPAR signaling pathway_Homo sapiens_hsa033200.42603235
131Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.42142316
132Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.41256615
133Phagosome_Homo sapiens_hsa041450.41139922
134Starch and sucrose metabolism_Homo sapiens_hsa005000.40844505
135Glycerolipid metabolism_Homo sapiens_hsa005610.40292789
136Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.39741483
137Retinol metabolism_Homo sapiens_hsa008300.38453765
138Thyroid cancer_Homo sapiens_hsa052160.36916993
139Endocytosis_Homo sapiens_hsa041440.36139301
140Propanoate metabolism_Homo sapiens_hsa006400.35911785
141MicroRNAs in cancer_Homo sapiens_hsa052060.35515120
142Rap1 signaling pathway_Homo sapiens_hsa040150.35272893
143Inositol phosphate metabolism_Homo sapiens_hsa005620.34916850
144Tryptophan metabolism_Homo sapiens_hsa003800.34558817
145Peroxisome_Homo sapiens_hsa041460.34185611
146Fatty acid metabolism_Homo sapiens_hsa012120.33082643
147Drug metabolism - other enzymes_Homo sapiens_hsa009830.32949316
148Regulation of actin cytoskeleton_Homo sapiens_hsa048100.32947291
149Epstein-Barr virus infection_Homo sapiens_hsa051690.32447992
150Melanogenesis_Homo sapiens_hsa049160.32138491
151Pathways in cancer_Homo sapiens_hsa052000.31280861
152Axon guidance_Homo sapiens_hsa043600.30679734
153Caffeine metabolism_Homo sapiens_hsa002320.30146898
154Glycerophospholipid metabolism_Homo sapiens_hsa005640.29690811
155Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.28035884
156SNARE interactions in vesicular transport_Homo sapiens_hsa041300.27291277
157Taste transduction_Homo sapiens_hsa047420.25675966
158Long-term potentiation_Homo sapiens_hsa047200.25455018
159Oocyte meiosis_Homo sapiens_hsa041140.23822242
160RNA degradation_Homo sapiens_hsa030180.23782031
161Choline metabolism in cancer_Homo sapiens_hsa052310.22541101
162Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.20624012

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