SLC39A4

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the zinc/iron-regulated transporter-like protein (ZIP) family. The encoded protein localizes to cell membranes and is required for zinc uptake in the intestine. Mutations in this gene result in acrodermatitis enteropathica. Multiple transcript variants encoding different isoforms have been found for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1proline biosynthetic process (GO:0006561)7.32425731
2proline metabolic process (GO:0006560)5.97568963
3transcription from mitochondrial promoter (GO:0006390)5.95643761
4sulfur amino acid catabolic process (GO:0000098)5.77041687
5angiotensin maturation (GO:0002003)5.10220698
6embryonic process involved in female pregnancy (GO:0060136)5.02804279
7NADH metabolic process (GO:0006734)4.94365597
8vitamin transmembrane transport (GO:0035461)4.82448289
9negative regulation of fatty acid biosynthetic process (GO:0045717)4.80127134
10replication fork processing (GO:0031297)4.54728320
11regulation of systemic arterial blood pressure by renin-angiotensin (GO:0003081)4.52843555
12intestinal cholesterol absorption (GO:0030299)4.48528182
13serine family amino acid catabolic process (GO:0009071)4.28827224
14positive regulation of protein homooligomerization (GO:0032464)4.27211859
15DNA deamination (GO:0045006)4.21268306
16regulation of integrin activation (GO:0033623)4.19992867
17glutamine family amino acid biosynthetic process (GO:0009084)4.18602611
18regulation of protein homooligomerization (GO:0032462)4.13371382
19heme transport (GO:0015886)4.11395220
20establishment of apical/basal cell polarity (GO:0035089)4.07741057
21very-low-density lipoprotein particle assembly (GO:0034379)4.01621600
22mitochondrial DNA metabolic process (GO:0032042)4.01521745
23alkaloid metabolic process (GO:0009820)3.92514986
24glycine metabolic process (GO:0006544)3.92131716
25erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)3.91160883
26L-phenylalanine metabolic process (GO:0006558)3.91160883
27regulation of cholesterol homeostasis (GO:2000188)3.89342643
28regulation of guanylate cyclase activity (GO:0031282)3.87800151
29mitotic G1 DNA damage checkpoint (GO:0031571)3.85530705
30intestinal epithelial cell development (GO:0060576)3.81127953
31cysteine metabolic process (GO:0006534)3.79375020
32fat-soluble vitamin biosynthetic process (GO:0042362)3.76105502
33oxidative demethylation (GO:0070989)3.69888808
34triglyceride-rich lipoprotein particle remodeling (GO:0034370)3.69791136
35maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)3.67585508
36mitochondrial ATP synthesis coupled proton transport (GO:0042776)3.66967209
37quinone biosynthetic process (GO:1901663)3.64540038
38pantothenate metabolic process (GO:0015939)3.64481576
39regulation of mitochondrial translation (GO:0070129)3.62969087
40ATP synthesis coupled proton transport (GO:0015986)3.57227703
41energy coupled proton transport, down electrochemical gradient (GO:0015985)3.57227703
42glyoxylate metabolic process (GO:0046487)3.55718186
43mitotic G1/S transition checkpoint (GO:0044819)3.53947464
44triglyceride homeostasis (GO:0070328)3.51331083
45acylglycerol homeostasis (GO:0055090)3.51331083
46serine family amino acid metabolic process (GO:0009069)3.49604361
47vitamin transport (GO:0051180)3.48916288
48protein complex biogenesis (GO:0070271)3.48667031
49deoxyribonucleoside monophosphate metabolic process (GO:0009162)3.47797623
50kynurenine metabolic process (GO:0070189)3.47666896
51glutathione biosynthetic process (GO:0006750)3.46713639
52folic acid metabolic process (GO:0046655)3.46266630
53mitochondrial electron transport, NADH to ubiquinone (GO:0006120)3.45877143
54L-phenylalanine catabolic process (GO:0006559)3.44066661
55erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)3.44066661
56aromatic amino acid family catabolic process (GO:0009074)3.38559707
57embryonic placenta development (GO:0001892)3.37861645
58trophectodermal cell differentiation (GO:0001829)3.35459762
59establishment or maintenance of monopolar cell polarity (GO:0061339)3.35158704
60establishment of monopolar cell polarity (GO:0061162)3.35158704
61electron transport chain (GO:0022900)3.33889977
62respiratory electron transport chain (GO:0022904)3.33621100
63indole-containing compound catabolic process (GO:0042436)3.32919973
64indolalkylamine catabolic process (GO:0046218)3.32919973
65tryptophan catabolic process (GO:0006569)3.32919973
66mitochondrial respiratory chain complex assembly (GO:0033108)3.31769095
67formation of translation preinitiation complex (GO:0001731)3.29995819
68cholesterol efflux (GO:0033344)3.29499043
69G1 DNA damage checkpoint (GO:0044783)3.29105638
70plasma lipoprotein particle assembly (GO:0034377)3.27984495
71mRNA cleavage (GO:0006379)3.23845450
72serine family amino acid biosynthetic process (GO:0009070)3.23405293
73establishment of protein localization to mitochondrial membrane (GO:0090151)3.22033430
74negative regulation of fatty acid metabolic process (GO:0045922)3.21185758
75labyrinthine layer development (GO:0060711)3.20967737
76proteasome assembly (GO:0043248)3.20757504
77intestinal absorption (GO:0050892)3.20609743
78purine nucleobase biosynthetic process (GO:0009113)3.20250322
79pyrimidine-containing compound transmembrane transport (GO:0072531)3.20176241
80nonribosomal peptide biosynthetic process (GO:0019184)3.19040176
81somatic hypermutation of immunoglobulin genes (GO:0016446)3.15542522
82somatic diversification of immune receptors via somatic mutation (GO:0002566)3.15542522
83bile acid metabolic process (GO:0008206)3.15307745
84urea metabolic process (GO:0019627)3.14692963
85urea cycle (GO:0000050)3.14692963
86fructose metabolic process (GO:0006000)3.13874131
87epoxygenase P450 pathway (GO:0019373)3.12226384
88mitochondrial respiratory chain complex I assembly (GO:0032981)3.11620339
89NADH dehydrogenase complex assembly (GO:0010257)3.11620339
90mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.11620339
91bile acid and bile salt transport (GO:0015721)3.11234222
92negative regulation of fibrinolysis (GO:0051918)3.10887387
93purine ribonucleoside bisphosphate metabolic process (GO:0034035)3.10664317
943-phosphoadenosine 5-phosphosulfate metabolic process (GO:0050427)3.10664317
95regulation of protein activation cascade (GO:2000257)3.07913682
96L-ascorbic acid metabolic process (GO:0019852)3.06926691
97homocysteine metabolic process (GO:0050667)3.05832868
98tryptophan metabolic process (GO:0006568)3.04660406
99biotin metabolic process (GO:0006768)3.03263742
100vitamin biosynthetic process (GO:0009110)3.01945191
101GDP-mannose metabolic process (GO:0019673)3.01109857
102cytolysis (GO:0019835)3.00991540
103high-density lipoprotein particle remodeling (GO:0034375)3.00700412
104positive regulation of cellular amine metabolic process (GO:0033240)3.00657279
105positive regulation of guanylate cyclase activity (GO:0031284)2.98220528
106nitrogen cycle metabolic process (GO:0071941)2.96138961
107regulation of systemic arterial blood pressure mediated by a chemical signal (GO:0003044)2.95795407
108endocrine process (GO:0050886)2.95795407
109regulation of systemic arterial blood pressure by hormone (GO:0001990)2.95795407
110pyrimidine deoxyribonucleotide catabolic process (GO:0009223)2.93140466
111negative regulation of sterol transport (GO:0032372)2.92955479
112negative regulation of cholesterol transport (GO:0032375)2.92955479
113nucleotide transmembrane transport (GO:1901679)2.92653393
114cholesterol homeostasis (GO:0042632)2.92305666
115protein-lipid complex remodeling (GO:0034368)2.92303617
116macromolecular complex remodeling (GO:0034367)2.92303617
117plasma lipoprotein particle remodeling (GO:0034369)2.92303617
118regulation of complement activation (GO:0030449)2.91456440
119diacylglycerol metabolic process (GO:0046339)2.89646000
120amino-acid betaine metabolic process (GO:0006577)2.89015897
121complement activation, alternative pathway (GO:0006957)2.86816222
122sterol homeostasis (GO:0055092)2.86483185
123cobalamin metabolic process (GO:0009235)2.86365497
124negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)2.86172112
125aromatic amino acid family metabolic process (GO:0009072)2.86104737
126cellular ketone body metabolic process (GO:0046950)2.84307016
127sulfur amino acid metabolic process (GO:0000096)2.84202988
128negative regulation of Ras GTPase activity (GO:0034261)2.83900742
129protein-lipid complex assembly (GO:0065005)2.83871638
130arginine metabolic process (GO:0006525)2.83623335
131low-density lipoprotein particle remodeling (GO:0034374)2.83079454
132cytochrome complex assembly (GO:0017004)2.82424602
133iron coordination entity transport (GO:1901678)2.82418437
134regulation of cholesterol esterification (GO:0010872)2.82314286
135nucleoside diphosphate biosynthetic process (GO:0009133)2.81935330
136negative regulation of protein oligomerization (GO:0032460)2.81612179
137mannosylation (GO:0097502)2.80763872
138plasma lipoprotein particle organization (GO:0071827)2.80341203
139regulation of bile acid biosynthetic process (GO:0070857)2.80085430
140oxaloacetate metabolic process (GO:0006107)2.79395809
141reverse cholesterol transport (GO:0043691)2.78612647
142nucleotide-sugar biosynthetic process (GO:0009226)2.78175646
143nucleotide salvage (GO:0043173)2.78094133
144nucleobase biosynthetic process (GO:0046112)2.77455608
145oxidative phosphorylation (GO:0006119)2.76536093
146nucleoside transmembrane transport (GO:1901642)2.76378261
147regulation of fibrinolysis (GO:0051917)2.75593628
148glutathione derivative biosynthetic process (GO:1901687)2.75403787
149glutathione derivative metabolic process (GO:1901685)2.75403787
150regulation of triglyceride catabolic process (GO:0010896)2.75369989
151mitochondrial RNA metabolic process (GO:0000959)2.75136396
152drug metabolic process (GO:0017144)2.73498106
153oligosaccharide catabolic process (GO:0009313)2.70769403
154pseudouridine synthesis (GO:0001522)2.69622598
155urate metabolic process (GO:0046415)2.69324140
156quinone metabolic process (GO:1901661)2.68986065
157sulfate transmembrane transport (GO:1902358)2.67082728
158positive regulation of fatty acid biosynthetic process (GO:0045723)2.66430892
159base-excision repair, AP site formation (GO:0006285)2.65166182
160glutathione metabolic process (GO:0006749)2.64642621
161ketone biosynthetic process (GO:0042181)2.63522367
162lipoprotein metabolic process (GO:0042157)2.63117908
163pyrimidine deoxyribonucleotide metabolic process (GO:0009219)2.63080659
164respiratory chain complex IV assembly (GO:0008535)2.62607793
165flavonoid metabolic process (GO:0009812)2.61511678
166peptide hormone processing (GO:0016486)2.61305813
167maturation of 5.8S rRNA (GO:0000460)2.60083847
168mitochondrial calcium ion transport (GO:0006851)2.59700320
169regulation of metalloenzyme activity (GO:0048552)2.59198829
170regulation of systemic arterial blood pressure (GO:0003073)2.58998692
171protein maturation by protein folding (GO:0022417)2.56548785
172glycosphingolipid catabolic process (GO:0046479)2.55582891
173glycolipid catabolic process (GO:0019377)2.54900872
174modified amino acid transport (GO:0072337)2.53833786
175carbohydrate derivative transport (GO:1901264)2.53066097
176positive regulation of triglyceride lipase activity (GO:0061365)2.50426410
177positive regulation of lipoprotein lipase activity (GO:0051006)2.50426410

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1ESR1_17901129_ChIP-ChIP_LIVER_Mouse4.11935156
2TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat3.74209421
3RXR_22158963_ChIP-Seq_LIVER_Mouse3.65654609
4* PPARA_22158963_ChIP-Seq_LIVER_Mouse3.28393409
5E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.92232277
6SMAD1_18555785_ChIP-Seq_MESCs_Mouse2.69181828
7LXR_22158963_ChIP-Seq_LIVER_Mouse2.58590031
8CEBPA_23403033_ChIP-Seq_LIVER_Mouse2.56581346
9KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.55909128
10TP63_17297297_ChIP-ChIP_HaCaT_Human2.39437520
11FOXO1_23066095_ChIP-Seq_LIVER_Mouse2.33650838
12POU5F1_18700969_ChIP-ChIP_MESCs_Mouse2.32396384
13KLF5_18264089_ChIP-ChIP_MESCs_Mouse2.32098923
14KLF4_18264089_ChIP-ChIP_MESCs_Mouse2.32098923
15KLF2_18264089_ChIP-ChIP_MESCs_Mouse2.32098923
16MYC_18555785_ChIP-Seq_MESCs_Mouse2.18881233
17NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.17053128
18STAT3_1855785_ChIP-Seq_MESCs_Mouse2.16780687
19* NACC1_18358816_ChIP-ChIP_MESCs_Mouse2.16403086
20SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.15830679
21* NR0B1_18358816_ChIP-ChIP_MESCs_Mouse2.15424318
22EGR1_23403033_ChIP-Seq_LIVER_Mouse2.14574349
23PDX1_19855005_ChIP-ChIP_MIN6_Mouse2.13809386
24ZNF263_19887448_ChIP-Seq_K562_Human2.11776260
25GABP_17652178_ChIP-ChIP_JURKAT_Human2.06067097
26* KLF4_18358816_ChIP-ChIP_MESCs_Mouse2.05153172
27* NANOG_18700969_ChIP-ChIP_MESCs_Mouse2.02822073
28EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.00866871
29PPARG_19300518_ChIP-PET_3T3-L1_Mouse2.00693651
30CEBPB_23403033_ChIP-Seq_LIVER_Mouse2.00269908
31SRF_21415370_ChIP-Seq_HL-1_Mouse1.96496945
32SOX2_18358816_ChIP-ChIP_MESCs_Mouse1.96274201
33ESR1_15608294_ChIP-ChIP_MCF-7_Human1.95283694
34EST1_17652178_ChIP-ChIP_JURKAT_Human1.93478254
35HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.93260660
36TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.88085004
37* BCL6_27268052_Chip-Seq_Bcells_Human1.82910897
38MYC_19079543_ChIP-ChIP_MESCs_Mouse1.80380659
39TCF3_18692474_ChIP-Seq_MEFs_Mouse1.79457789
40* ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.75726373
41ELF1_17652178_ChIP-ChIP_JURKAT_Human1.74351609
42SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.72590485
43MYC_18358816_ChIP-ChIP_MESCs_Mouse1.71540860
44NANOG_18555785_ChIP-Seq_MESCs_Mouse1.71120735
45TCF3_18692474_ChIP-Seq_MESCs_Mouse1.69326818
46NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.67136613
47CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.64451628
48CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.59894008
49POU5F1_16518401_ChIP-PET_MESCs_Mouse1.59225421
50DCP1A_22483619_ChIP-Seq_HELA_Human1.58063549
51* P68_20966046_ChIP-Seq_HELA_Human1.57020785
52E2F1_20622854_ChIP-Seq_HELA_Human1.52570365
53CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.52064200
54CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.50225580
55DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.49698753
56RACK7_27058665_Chip-Seq_MCF-7_Human1.48839371
57RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.48136947
58XRN2_22483619_ChIP-Seq_HELA_Human1.47611943
59GATA4_25053715_ChIP-Seq_YYC3_Human1.46903513
60YY1_22570637_ChIP-Seq_MALME-3M_Human1.46015852
61FOXM1_23109430_ChIP-Seq_U2OS_Human1.45964351
62E2F7_22180533_ChIP-Seq_HELA_Human1.44370114
63THAP11_20581084_ChIP-Seq_MESCs_Mouse1.44331223
64LXR_22292898_ChIP-Seq_THP-1_Human1.42517811
65HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.40727406
66SOX2_18692474_ChIP-Seq_MEFs_Mouse1.40129714
67MYC_19030024_ChIP-ChIP_MESCs_Mouse1.39835749
68KLF4_18555785_ChIP-Seq_MESCs_Mouse1.38657064
69NANOG_18358816_ChIP-ChIP_MESCs_Mouse1.38237630
70OCT4_18692474_ChIP-Seq_MEFs_Mouse1.37722583
71CDX2_20551321_ChIP-Seq_CACO-2_Human1.37573137
72JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.37016295
73SOX2_27498859_Chip-Seq_STOMACH_Mouse1.36122295
74EBNA2_21746931_ChIP-Seq_IB4-LCL_Human1.35997495
75BMI1_19503595_ChIP-Seq_MEFsC_Mouse1.34995832
76RBPJ_21746931_ChIP-Seq_IB4-LCL_Human1.33107024
77FOXP3_21729870_ChIP-Seq_TREG_Human1.33002225
78ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.32948219
79* E2F1_18555785_ChIP-Seq_MESCs_Mouse1.32261386
80VDR_21846776_ChIP-Seq_THP-1_Human1.32071038
81FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.30757524
82RXRA_24833708_ChIP-Seq_LIVER_Mouse1.30479630
83SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.30463253
84VDR_23849224_ChIP-Seq_CD4+_Human1.29426007
85* POU5F1_18692474_ChIP-Seq_MESCs_Mouse1.28742236
86RARG_19884340_ChIP-ChIP_MEFs_Mouse1.28492596
87CTCF_26484167_Chip-Seq_Bcells_Mouse1.27241864
88CTCF_18555785_ChIP-Seq_MESCs_Mouse1.25865968
89P300_27268052_Chip-Seq_Bcells_Human1.25137784
90NANOG_21062744_ChIP-ChIP_HESCs_Human1.24287069
91* FOXP1_21924763_ChIP-Seq_HESCs_Human1.24024348
92SA1_27219007_Chip-Seq_Bcells_Human1.23491939
93STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.23313739
94POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.22983289
95SMAD2/3_21741376_ChIP-Seq_ESCs_Human1.22961697
96NANOG_18692474_ChIP-Seq_MEFs_Mouse1.22761174
97NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.22210731
98CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.22182911
99ESR2_21235772_ChIP-Seq_MCF-7_Human1.21724871
100ELF1_20517297_ChIP-Seq_JURKAT_Human1.20699210
101NANOG_18692474_ChIP-Seq_MESCs_Mouse1.19521752
102SOX2_18692474_ChIP-Seq_MESCs_Mouse1.19101351
103RARA_24833708_ChIP-Seq_LIVER_Mouse1.18928708
104RARB_24833708_ChIP-Seq_LIVER_Mouse1.18923083
105PU.1_20513432_ChIP-Seq_Bcells_Mouse1.18716623
106* CTCF_20526341_ChIP-Seq_ESCs_Human1.18576350
107* TET1_21451524_ChIP-Seq_MESCs_Mouse1.18194613
108FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.18167955
109TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.16558662
110NANOG_18347094_ChIP-ChIP_MESCs_Mouse1.16452794
111ERG_21242973_ChIP-ChIP_JURKAT_Human1.16012403
112AR_21909140_ChIP-Seq_LNCAP_Human1.15667844
113IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.15658527
114POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.14868767
115* CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.13634545
116SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.12926294
117SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.11617167
118SREBP2_21459322_ChIP-Seq_LIVER_Mouse1.11174744
119SRY_22984422_ChIP-ChIP_TESTIS_Rat1.10427243
120KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.09764127
121NELFA_20434984_ChIP-Seq_ESCs_Mouse1.09462459
122ETS1_20019798_ChIP-Seq_JURKAT_Human1.09400792
123RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.07943003
124TTF2_22483619_ChIP-Seq_HELA_Human1.07861075
125ATF3_27146783_Chip-Seq_COLON_Human1.07485680
126* EOMES_20176728_ChIP-ChIP_TSCs_Mouse1.07236167
127NANOG_20526341_ChIP-Seq_ESCs_Human1.06928828
128* TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.06708811
129HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.06123819
130CREB1_15753290_ChIP-ChIP_HEK293T_Human1.05780168
131TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.05185586
132KAP1_27257070_Chip-Seq_ESCs_Mouse1.04160800
133SPI1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.03131104
134YY1_21170310_ChIP-Seq_MESCs_Mouse1.03125001
135IRF8_22096565_ChIP-ChIP_GC-B_Human1.02274384
136KDM5A_27292631_Chip-Seq_BREAST_Human1.01840663
137STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.01294639
138TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.00810678
139ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.00777989
140SA1_27219007_Chip-Seq_ERYTHROID_Human0.99975894
141SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.99854152
142* GATA6_25053715_ChIP-Seq_YYC3_Human0.99770330
143P53_21459846_ChIP-Seq_SAOS-2_Human0.99656885
144KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human0.98715907
145* BCOR_27268052_Chip-Seq_Bcells_Human0.98694112
146SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse0.98429450
147* ERA_21632823_ChIP-Seq_H3396_Human0.97908057
148RAC3_21632823_ChIP-Seq_H3396_Human0.97863079
149CTCF_27219007_Chip-Seq_ERYTHROID_Human0.96671660
150PHF8_20622854_ChIP-Seq_HELA_Human0.96357410
151STAT1_20625510_ChIP-Seq_HELA_Human0.96222487
152ZNF652_21678463_ChIP-ChIP_ZR75-1_Human0.96037385
153PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse0.95873760
154MYCN_18555785_ChIP-Seq_MESCs_Mouse0.95180086
155HIF1A_21447827_ChIP-Seq_MCF-7_Human0.95085727
156CLOCK_20551151_ChIP-Seq_293T_Human0.94665204
157GABP_19822575_ChIP-Seq_HepG2_Human0.94621377
158ETS1_21867929_ChIP-Seq_TH2_Mouse0.93423033
159* ELK3_25401928_ChIP-Seq_HUVEC_Human0.91439940
160TCF7L2_21901280_ChIP-Seq_H4IIE_Rat0.90635404

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005085_abnormal_gallbladder_physiolo4.85526682
2MP0005360_urolithiasis4.79145988
3MP0002139_abnormal_hepatobiliary_system4.73481762
4MP0005365_abnormal_bile_salt4.36421165
5MP0009840_abnormal_foam_cell3.55738367
6MP0003806_abnormal_nucleotide_metabolis3.26459443
7MP0008875_abnormal_xenobiotic_pharmacok3.10858091
8MP0008057_abnormal_DNA_replication3.04779450
9MP0003183_abnormal_peptide_metabolism2.59048220
10MP0001666_abnormal_nutrient_absorption2.47257208
11MP0004019_abnormal_vitamin_homeostasis2.45994540
12MP0004147_increased_porphyrin_level2.33503342
13MP0004264_abnormal_extraembryonic_tissu2.27675440
14MP0009278_abnormal_bone_marrow2.26655074
15MP0002876_abnormal_thyroid_physiology2.24783149
16MP0009379_abnormal_foot_pigmentation2.20936983
17MP0010329_abnormal_lipoprotein_level2.14830550
18MP0010030_abnormal_orbit_morphology2.09491855
19MP0003252_abnormal_bile_duct2.00545259
20MP0003195_calcinosis1.98630351
21MP0003191_abnormal_cellular_cholesterol1.95714685
22MP0000678_abnormal_parathyroid_gland1.92245214
23MP0003693_abnormal_embryo_hatching1.87637598
24MP0004957_abnormal_blastocyst_morpholog1.84347228
25MP0005636_abnormal_mineral_homeostasis1.83358033
26MP0005332_abnormal_amino_acid1.81042542
27MP0003453_abnormal_keratinocyte_physiol1.79982868
28MP0010234_abnormal_vibrissa_follicle1.78479014
29MP0005083_abnormal_biliary_tract1.73590211
30MP0000609_abnormal_liver_physiology1.72183101
31MP0002009_preneoplasia1.66617480
32MP0002796_impaired_skin_barrier1.65546940
33MP0000566_synostosis1.63723976
34MP0001664_abnormal_digestion1.61243515
35MP0010352_gastrointestinal_tract_polyps1.57554097
36MP0001765_abnormal_ion_homeostasis1.54905615
37MP0009780_abnormal_chondrocyte_physiolo1.54146538
38MP0004043_abnormal_pH_regulation1.54059685
39MP0000462_abnormal_digestive_system1.42335412
40MP0005397_hematopoietic_system_phenotyp1.40486602
41MP0001545_abnormal_hematopoietic_system1.40486602
42MP0008995_early_reproductive_senescence1.40110955
43MP0000490_abnormal_crypts_of1.39954819
44MP0006036_abnormal_mitochondrial_physio1.36922779
45MP0005319_abnormal_enzyme/_coenzyme1.36202869
46MP0003119_abnormal_digestive_system1.35481791
47MP0003111_abnormal_nucleus_morphology1.34976892
48MP0003786_premature_aging1.34560650
49MP0005058_abnormal_lysosome_morphology1.30218389
50MP0008872_abnormal_physiological_respon1.29707401
51MP0003656_abnormal_erythrocyte_physiolo1.28975669
52MP0010094_abnormal_chromosome_stability1.28366045
53MP0002118_abnormal_lipid_homeostasis1.28202802
54MP0005646_abnormal_pituitary_gland1.27284534
55MP0002086_abnormal_extraembryonic_tissu1.27179040
56MP0005670_abnormal_white_adipose1.26999850
57* MP0003718_maternal_effect1.25684279
58MP0000538_abnormal_urinary_bladder1.22462945
59MP0005171_absent_coat_pigmentation1.21080053
60MP0001756_abnormal_urination1.16939379
61MP0001764_abnormal_homeostasis1.16590501
62MP0003705_abnormal_hypodermis_morpholog1.14645478
63MP0005464_abnormal_platelet_physiology1.11733170
64MP0003890_abnormal_embryonic-extraembry1.11109967
65MP0003172_abnormal_lysosome_physiology1.09445275
66MP0002138_abnormal_hepatobiliary_system1.09124551
67MP0000579_abnormal_nail_morphology1.08230170
68MP0009053_abnormal_anal_canal1.07333137
69MP0004233_abnormal_muscle_weight1.06853506
70MP0001730_embryonic_growth_arrest1.05355892
71MP0002136_abnormal_kidney_physiology1.03406395
72MP0000477_abnormal_intestine_morphology1.03202603
73MP0005266_abnormal_metabolism1.02170426
74MP0010155_abnormal_intestine_physiology1.01857047
75MP0005377_hearing/vestibular/ear_phenot1.01081276
76MP0003878_abnormal_ear_physiology1.01081276
77MP0003283_abnormal_digestive_organ1.00689865
78MP0003638_abnormal_response/metabolism_0.98641746
79MP0009642_abnormal_blood_homeostasis0.97178066
80MP0000598_abnormal_liver_morphology0.97175452
81MP0005501_abnormal_skin_physiology0.96892185
82MP0003567_abnormal_fetal_cardiomyocyte0.96423630
83MP0005448_abnormal_energy_balance0.94937922
84MP0005076_abnormal_cell_differentiation0.94751242
85MP0001663_abnormal_digestive_system0.94505996
86* MP0005380_embryogenesis_phenotype0.93911509
87* MP0001672_abnormal_embryogenesis/_devel0.93911509
88MP0004133_heterotaxia0.92748269
89MP0002132_abnormal_respiratory_system0.90498197
90MP0005410_abnormal_fertilization0.89699430
91MP0005584_abnormal_enzyme/coenzyme_acti0.89348278
92MP0002693_abnormal_pancreas_physiology0.88123576
93* MP0001697_abnormal_embryo_size0.87904087
94MP0005023_abnormal_wound_healing0.87529718
95MP0000470_abnormal_stomach_morphology0.87496309
96MP0002089_abnormal_postnatal_growth/wei0.87145953
97MP0002653_abnormal_ependyma_morphology0.86717273
98MP0004782_abnormal_surfactant_physiolog0.86504430
99MP0003315_abnormal_perineum_morphology0.85815333
100MP0001873_stomach_inflammation0.85393788
101MP0002060_abnormal_skin_morphology0.85249609
102MP0008469_abnormal_protein_level0.84947440
103MP0000516_abnormal_urinary_system0.84867565
104MP0005367_renal/urinary_system_phenotyp0.84867565
105MP0008932_abnormal_embryonic_tissue0.84655444
106MP0003879_abnormal_hair_cell0.83948749
107MP0002084_abnormal_developmental_patter0.83940662
108MP0002098_abnormal_vibrissa_morphology0.83892355
109MP0001905_abnormal_dopamine_level0.83670714
110MP0009643_abnormal_urine_homeostasis0.83096969
111MP0003077_abnormal_cell_cycle0.82896876
112MP0002282_abnormal_trachea_morphology0.81947174
113MP0002163_abnormal_gland_morphology0.81817235
114MP0005376_homeostasis/metabolism_phenot0.81666860
115MP0003186_abnormal_redox_activity0.81638794
116MP0002085_abnormal_embryonic_tissue0.81516269
117MP0002254_reproductive_system_inflammat0.80872571
118MP0003953_abnormal_hormone_level0.80547363
119MP0002160_abnormal_reproductive_system0.80286442
120MP0000372_irregular_coat_pigmentation0.79624069
121MP0004197_abnormal_fetal_growth/weight/0.79440261
122MP0001881_abnormal_mammary_gland0.77127845
123MP0000681_abnormal_thyroid_gland0.76401624
124MP0005451_abnormal_body_composition0.76192846
125MP0003866_abnormal_defecation0.75882635
126MP0000350_abnormal_cell_proliferation0.75535760
127MP0002269_muscular_atrophy0.75025858
128MP0005381_digestive/alimentary_phenotyp0.74586555
129MP0002019_abnormal_tumor_incidence0.73883153
130MP0009115_abnormal_fat_cell0.72706846
131* MP0002080_prenatal_lethality0.72047532
132* MP0005395_other_phenotype0.71832229
133MP0000639_abnormal_adrenal_gland0.71051193
134MP0000371_diluted_coat_color0.70936429
135MP0009697_abnormal_copulation0.70349643
136MP0005166_decreased_susceptibility_to0.69616470
137MP0008058_abnormal_DNA_repair0.69279803
138MP0006082_CNS_inflammation0.69108487
139MP0010307_abnormal_tumor_latency0.68911613
140MP0003941_abnormal_skin_development0.68399408
141MP0009333_abnormal_splenocyte_physiolog0.68263234
142* MP0003984_embryonic_growth_retardation0.68172717
143MP0000230_abnormal_systemic_arterial0.67482252
144* MP0002088_abnormal_embryonic_growth/wei0.66318462
145MP0001845_abnormal_inflammatory_respons0.66243030
146MP0002111_abnormal_tail_morphology0.65799363
147MP0002078_abnormal_glucose_homeostasis0.65252622
148MP0000537_abnormal_urethra_morphology0.65195463
149MP0002909_abnormal_adrenal_gland0.62936653
150MP0002148_abnormal_hypersensitivity_rea0.62370476
151MP0002166_altered_tumor_susceptibility0.61311393
152MP0005389_reproductive_system_phenotype0.61140811
153MP0005645_abnormal_hypothalamus_physiol0.60701211
154MP0002938_white_spotting0.59932641
155MP0005379_endocrine/exocrine_gland_phen0.59197509
156MP0005174_abnormal_tail_pigmentation0.58252734
157MP0005408_hypopigmentation0.55567645
158MP0003123_paternal_imprinting0.54035633
159MP0002837_dystrophic_cardiac_calcinosis0.53898971

Predicted human phenotypes

RankGene SetZ-score
1Hypobetalipoproteinemia (HP:0003563)5.05208964
2Abnormality of monocarboxylic acid metabolism (HP:0010996)4.56130783
3Intrahepatic cholestasis (HP:0001406)4.51093230
4Abnormality of aromatic amino acid family metabolism (HP:0004338)4.33182690
5Hypochromic microcytic anemia (HP:0004840)4.33003797
6Abnormality of proline metabolism (HP:0010907)4.06461944
7Hydroxyprolinuria (HP:0003080)4.06461944
8* Pustule (HP:0200039)3.91671646
9Hyperglycinuria (HP:0003108)3.78188772
10Deep venous thrombosis (HP:0002625)3.77867554
11Hyperglycinemia (HP:0002154)3.74679284
12Xanthomatosis (HP:0000991)3.74220329
13Polycythemia (HP:0001901)3.66011398
14Abnormal mitochondria in muscle tissue (HP:0008316)3.61641629
15Vaginal fistula (HP:0004320)3.61243734
16Concave nail (HP:0001598)3.56057097
17Hypolipoproteinemia (HP:0010981)3.52632203
18Gout (HP:0001997)3.51206419
19Facial hemangioma (HP:0000329)3.47122812
20Acute encephalopathy (HP:0006846)3.44788531
21Poikiloderma (HP:0001029)3.44255994
22Turricephaly (HP:0000262)3.41724600
23Hepatic necrosis (HP:0002605)3.41530414
24Rectovaginal fistula (HP:0000143)3.40511230
25Rectal fistula (HP:0100590)3.40511230
26Ulnar bowing (HP:0003031)3.38390477
27Aplasia/Hypoplasia involving the carpal bones (HP:0006502)3.37339501
28Acute necrotizing encephalopathy (HP:0006965)3.34782449
29Mitochondrial inheritance (HP:0001427)3.28496889
30Glycosuria (HP:0003076)3.27909650
31Abnormality of urine glucose concentration (HP:0011016)3.27909650
32Abnormality of glycine metabolism (HP:0010895)3.20087554
33Abnormality of serine family amino acid metabolism (HP:0010894)3.20087554
34Hepatocellular necrosis (HP:0001404)3.19992875
35Abnormal activity of mitochondrial respiratory chain (HP:0011922)3.17586217
36Decreased activity of mitochondrial respiratory chain (HP:0008972)3.17586217
37Rib fusion (HP:0000902)3.17070340
38Abnormality of the vitamin B12 metabolism (HP:0004341)3.15684877
39Abnormality of vitamin B metabolism (HP:0004340)3.15430089
40Abnormal hemoglobin (HP:0011902)3.08422079
41Short humerus (HP:0005792)3.05520079
42Male infertility (HP:0003251)3.05484895
43Increased CSF lactate (HP:0002490)3.02826447
44Aplasia/hypoplasia of the humerus (HP:0006507)2.99825464
45Hyperammonemia (HP:0001987)2.98607886
46Annular pancreas (HP:0001734)2.98557708
47Tongue fasciculations (HP:0001308)2.98512947
48Fat malabsorption (HP:0002630)2.97946250
49Opisthotonus (HP:0002179)2.96472453
50Abnormality of the level of lipoprotein cholesterol (HP:0010979)2.95895658
51Prolonged partial thromboplastin time (HP:0003645)2.94862477
52Intestinal fistula (HP:0100819)2.92719609
53Abnormality of glutamine family amino acid metabolism (HP:0010902)2.88239947
54Type I transferrin isoform profile (HP:0003642)2.87056655
55Abnormality of dicarboxylic acid metabolism (HP:0010995)2.85854360
56Dicarboxylic aciduria (HP:0003215)2.85854360
57Hyperlipoproteinemia (HP:0010980)2.83324164
58Increased IgM level (HP:0003496)2.80413993
59Malnutrition (HP:0004395)2.80206059
60Nausea (HP:0002018)2.78262133
61Muscle fibrillation (HP:0010546)2.73512599
62Abnormality of sulfur amino acid metabolism (HP:0004339)2.71552490
63Absent radius (HP:0003974)2.69683697
64Complement deficiency (HP:0004431)2.69460230
65Myocardial infarction (HP:0001658)2.65476344
66Progressive macrocephaly (HP:0004481)2.63425867
67* Lethargy (HP:0001254)2.62553047
68Confusion (HP:0001289)2.62370097
69Generalized aminoaciduria (HP:0002909)2.61953080
70Coronal craniosynostosis (HP:0004440)2.60913130
71Abnormality of pyrimidine metabolism (HP:0004353)2.60766136
72Lactic acidosis (HP:0003128)2.60084480
73Increased intramyocellular lipid droplets (HP:0012240)2.59918798
74Cerebral palsy (HP:0100021)2.59344332
75Abnormal isoelectric focusing of serum transferrin (HP:0003160)2.58986048
76Abnormal protein N-linked glycosylation (HP:0012347)2.58986048
77Abnormal protein glycosylation (HP:0012346)2.58986048
78Abnormal glycosylation (HP:0012345)2.58986048
79Megaloblastic anemia (HP:0001889)2.57952424
80Increased muscle lipid content (HP:0009058)2.57922156
81Hypoalphalipoproteinemia (HP:0003233)2.57196303
82Absent forearm bone (HP:0003953)2.56835492
83Aplasia involving forearm bones (HP:0009822)2.56835492
84Dysautonomia (HP:0002459)2.55346656
85Acanthocytosis (HP:0001927)2.47946589
86Delayed CNS myelination (HP:0002188)2.47628588
87Breast hypoplasia (HP:0003187)2.47301638
88Cerebral edema (HP:0002181)2.46940271
89Petechiae (HP:0000967)2.42766999
90Pigmentary retinal degeneration (HP:0001146)2.42634382
91Widely patent fontanelles and sutures (HP:0004492)2.42257336
92Increased serum lactate (HP:0002151)2.39225058
93Abnormality of vitamin metabolism (HP:0100508)2.35637111
94Methylmalonic aciduria (HP:0012120)2.35013189
95Aplasia/Hypoplasia of the vertebrae (HP:0008515)2.33533771
96Vertebral hypoplasia (HP:0008417)2.33533771
97Abnormality of male internal genitalia (HP:0000022)2.28793853
98Steatorrhea (HP:0002570)2.26628024
993-Methylglutaconic aciduria (HP:0003535)2.25769982
100Abnormality of magnesium homeostasis (HP:0004921)2.24730390
101Abnormality of aspartate family amino acid metabolism (HP:0010899)2.24527988
102Hypochromic anemia (HP:0001931)2.24268460
103Hyperthyroidism (HP:0000836)2.23025737
104Microretrognathia (HP:0000308)2.22562534
105Impulsivity (HP:0100710)2.21648648
106Hemorrhage of the eye (HP:0011885)2.21322323
107Esophageal varix (HP:0002040)2.21195584
108Abnormality of nucleobase metabolism (HP:0010932)2.21052083
109Seborrheic dermatitis (HP:0001051)2.19605885
110Respiratory failure (HP:0002878)2.17947265
111Abnormality of complement system (HP:0005339)2.17356890
112Reduced antithrombin III activity (HP:0001976)2.16317574
113Mucopolysacchariduria (HP:0008155)2.16132310
114Urinary glycosaminoglycan excretion (HP:0003541)2.16132310
115Abnormality of methionine metabolism (HP:0010901)2.15015349
116Squamous cell carcinoma (HP:0002860)2.14616578
117Abnormality of small intestinal villus morphology (HP:0011472)2.13620563
118Villous atrophy (HP:0011473)2.13620563
119Aplasia/Hypoplasia involving the musculature (HP:0001460)2.12379169
120Macrocytic anemia (HP:0001972)2.12375160
121Metabolic acidosis (HP:0001942)2.10692027
122Patellar aplasia (HP:0006443)2.10165423
123Abnormality of placental membranes (HP:0011409)2.09576474
124Amniotic constriction ring (HP:0009775)2.09576474
125Abnormality of serum amino acid levels (HP:0003112)2.09176257
126Abnormal number of erythroid precursors (HP:0012131)2.08481587
127Ileus (HP:0002595)2.06851828
128Testicular atrophy (HP:0000029)2.06016407
129Aplasia of the musculature (HP:0100854)2.03023270
130Orthostatic hypotension (HP:0001278)2.02781859
131Diaphragmatic weakness (HP:0009113)2.02475548
132Lipid accumulation in hepatocytes (HP:0006561)2.02085678
133Abnormality of purine metabolism (HP:0004352)2.01195056
134Bowing of the arm (HP:0006488)2.00604285
135Bowed forearm bones (HP:0003956)2.00604285
136Aplasia/Hypoplasia of the patella (HP:0006498)2.00151861
137Chronic diarrhea (HP:0002028)1.99770708
138Increased serum pyruvate (HP:0003542)1.97616570
139Dysostosis multiplex (HP:0000943)1.97419525
140Spastic diplegia (HP:0001264)1.96688951
141Ketosis (HP:0001946)1.96184893
142Epidermoid cyst (HP:0200040)1.95752223
143Abnormality of pyruvate family amino acid metabolism (HP:0010915)1.95308369
144Abnormality of alanine metabolism (HP:0010916)1.95308369
145Hyperalaninemia (HP:0003348)1.95308369
146Vascular calcification (HP:0004934)1.95182854
147Growth hormone excess (HP:0000845)1.95154542
148Alkalosis (HP:0001948)1.94006624
149Increased purine levels (HP:0004368)1.93327851
150Hyperuricemia (HP:0002149)1.93327851
151Abnormality of the labia minora (HP:0012880)1.91733675
152Proximal tubulopathy (HP:0000114)1.91351429
153Renal Fanconi syndrome (HP:0001994)1.90022390
154Capillary hemangiomas (HP:0005306)1.89535174
155Vomiting (HP:0002013)1.89515669
156Hypoglycemic coma (HP:0001325)1.89176442
157Increased hepatocellular lipid droplets (HP:0006565)1.89097538
158Abnormal urine phosphate concentration (HP:0012599)1.88723865
159Plantar hyperkeratosis (HP:0007556)1.88452043
160Hyperphosphaturia (HP:0003109)1.88048344
161Abnormality of glycolysis (HP:0004366)1.87999111
162Short chin (HP:0000331)1.87757002
163Abnormality of the common coagulation pathway (HP:0010990)1.86612532
164Abnormality of mucopolysaccharide metabolism (HP:0011020)1.85839821
165Abnormality of polysaccharide metabolism (HP:0011012)1.85839821
166Abnormality of glycosaminoglycan metabolism (HP:0004371)1.85839821
167Abnormality of the aortic arch (HP:0012303)1.85542889
168Ketoacidosis (HP:0001993)1.84361917
169Abnormal hair laboratory examination (HP:0003328)1.83987634
170Joint hemorrhage (HP:0005261)1.82291542
171Abnormal trabecular bone morphology (HP:0100671)1.81858752
172Hypokinesia (HP:0002375)1.81402422
173Pancreatic islet-cell hyperplasia (HP:0004510)1.80648329
174Abnormal cartilage morphology (HP:0002763)1.80394741
175Hypercholesterolemia (HP:0003124)1.80275913
176Nephrolithiasis (HP:0000787)1.79800635
177Abnormal pupillary function (HP:0007686)1.79562729
178Purpura (HP:0000979)1.79562368
179Glomerulosclerosis (HP:0000096)1.78498360
180CNS demyelination (HP:0007305)1.74625315

Predicted kinase interactions (KEA)

RankGene SetZ-score
1ICK4.73726548
2EPHA24.50186051
3DDR24.23382233
4MAPK154.11223592
5NME24.06590825
6VRK23.94914488
7MAP3K63.15872871
8AKT33.09288271
9MAP3K113.05740637
10PINK12.95461180
11MATK2.63440877
12BUB12.46842528
13WNK42.35501125
14NME12.31910143
15TYRO32.31349928
16PIM22.30235243
17FGR2.18886947
18IRAK32.14677745
19CSK2.03625486
20TLK11.98808137
21WEE11.85360838
22TESK11.83576032
23DYRK1B1.76559993
24BMX1.75725685
25DAPK11.72635445
26CDK81.70327877
27CDK71.63575201
28STK161.52528228
29PDGFRA1.52474179
30BCKDK1.50067500
31CDK61.45388199
32MAPKAPK31.44776071
33PIM11.41247785
34NUAK11.41095562
35PRKD21.38025797
36ADRBK21.36853763
37EIF2AK11.32427096
38YES11.31473303
39ABL21.28528351
40LATS21.28195739
41MUSK1.23990801
42SMG11.21802654
43MAPK111.19682901
44LMTK21.19071918
45MAP2K61.18620630
46PLK11.15927523
47GSK3A1.11943503
48MST1R1.11252177
49GRK11.10858219
50FLT31.06552351
51FGFR41.04117226
52DYRK30.98614615
53MAP4K20.97718493
54NEK10.97059871
55CHEK20.96831555
56RPS6KB20.95067305
57LIMK10.92381327
58STK390.90947137
59MAP2K20.90944868
60MAP3K120.89944279
61TXK0.89521881
62NEK20.88908696
63TRPM70.86942857
64IKBKB0.86534581
65UHMK10.84469848
66SCYL20.84055569
67DAPK20.82596642
68PRKAA10.82568178
69TTK0.81561235
70RPS6KL10.81275457
71RPS6KC10.81275457
72TAOK20.78908595
73MAP4K10.78306299
74ITK0.78229454
75MTOR0.77939159
76BMPR1B0.77102121
77STK30.76949142
78MAP3K100.73180708
79PTK20.72814976
80PRKCI0.71752158
81MST40.71565527
82VRK10.70908617
83CSF1R0.70044873
84PTK60.69296230
85STK100.69271325
86RPS6KA60.69247721
87PAK40.68949175
88ZAK0.68170953
89ILK0.67986238
90MAPKAPK50.67319250
91PBK0.66671831
92LATS10.66024581
93AURKB0.65663926
94INSRR0.62647007
95CDC42BPA0.61777368
96CSNK1G10.61692444
97CSNK1G30.60914322
98GRK60.59912338
99RPS6KA10.59609826
100MAP3K30.59459465
101BRSK20.59129969
102MAP3K80.58564735
103ERN10.57805389
104TAOK10.57778378
105CAMK2G0.56850434
106TESK20.54521637
107STK38L0.52987540
108AURKA0.52829007
109MAP3K20.52055888
110OXSR10.50608952
111MAP3K90.50099493
112PRKAA20.49871702
113TBK10.49577781
114ALK0.49302654
115FRK0.47256576
116CDK120.47238876
117PHKG10.46898062
118PHKG20.46898062
119CSNK2A10.46643126
120CDK40.45269323
121ERBB40.44312720
122TAOK30.43601247
123TRIB30.42927236
124MAPK40.42654865
125EGFR0.41805421
126ACVR1B0.41015085
127MET0.39536506
128MYLK0.39110410
129PDPK10.39027417
130SIK10.38983064
131RIPK10.38926291
132PRKG20.38723059
133DAPK30.38544426
134CDK20.36809405
135RAF10.36278017
136PAK10.34540278
137MAPKAPK20.34537417
138PRKCA0.33589486
139PLK40.31257752
140CAMK2B0.31165334
141LRRK20.30982227
142ARAF0.30700307
143CAMK2D0.30692399
144CSNK1A10.30261155
145PRKCZ0.29924310
146RPS6KA50.29253129
147ADRBK10.29062834
148CSNK1A1L0.28830107
149CSNK2A20.28803814
150PDK20.28329300
151MAP3K10.28047626
152PRKCD0.27960700
153PKN20.27155401
154MAPK10.26560847
155HIPK20.26483367
156ERBB20.25625048
157TSSK60.25464423
158CHUK0.24398017
159MAPK30.24107877
160KDR0.23758983
161CSNK1E0.22915334

Predicted pathways (KEGG)

RankGene SetZ-score
1Folate biosynthesis_Homo sapiens_hsa007902.86144986
2Fatty acid biosynthesis_Homo sapiens_hsa000612.80444073
3Primary bile acid biosynthesis_Homo sapiens_hsa001202.72050608
4Vitamin B6 metabolism_Homo sapiens_hsa007502.68029070
5Arginine biosynthesis_Homo sapiens_hsa002202.55944162
6Glycine, serine and threonine metabolism_Homo sapiens_hsa002602.44150889
7Ascorbate and aldarate metabolism_Homo sapiens_hsa000532.38145852
8Pentose and glucuronate interconversions_Homo sapiens_hsa000402.32176059
9Oxidative phosphorylation_Homo sapiens_hsa001902.30644821
10Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006302.13804507
11Nitrogen metabolism_Homo sapiens_hsa009102.10801897
12Ribosome_Homo sapiens_hsa030102.02643189
13Biosynthesis of amino acids_Homo sapiens_hsa012301.97914800
142-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.97814679
15Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.95829694
16Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.94241795
17Tryptophan metabolism_Homo sapiens_hsa003801.85216456
18Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.82894002
19Arginine and proline metabolism_Homo sapiens_hsa003301.82773606
20Parkinsons disease_Homo sapiens_hsa050121.80473620
21Drug metabolism - other enzymes_Homo sapiens_hsa009831.77877725
22Base excision repair_Homo sapiens_hsa034101.76009223
23Mismatch repair_Homo sapiens_hsa034301.74437259
24Fatty acid metabolism_Homo sapiens_hsa012121.74184296
25Fat digestion and absorption_Homo sapiens_hsa049751.73337827
26Sulfur relay system_Homo sapiens_hsa041221.72351862
27Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.68088994
28Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.67669762
29Complement and coagulation cascades_Homo sapiens_hsa046101.62469201
30Histidine metabolism_Homo sapiens_hsa003401.61337707
31Vitamin digestion and absorption_Homo sapiens_hsa049771.60300329
32Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.59750890
33Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.56843805
34Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.46707578
35Fructose and mannose metabolism_Homo sapiens_hsa000511.45364696
36Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.44880530
37Chemical carcinogenesis_Homo sapiens_hsa052041.43981524
38Selenocompound metabolism_Homo sapiens_hsa004501.43637689
39Fatty acid degradation_Homo sapiens_hsa000711.41579123
40Cysteine and methionine metabolism_Homo sapiens_hsa002701.37479260
41Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.37368688
42Caffeine metabolism_Homo sapiens_hsa002321.37070224
43Glutathione metabolism_Homo sapiens_hsa004801.36842954
44Maturity onset diabetes of the young_Homo sapiens_hsa049501.36006834
45Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.35843696
46Arachidonic acid metabolism_Homo sapiens_hsa005901.33972700
47Butanoate metabolism_Homo sapiens_hsa006501.30581385
48Retinol metabolism_Homo sapiens_hsa008301.29879088
49Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.28796702
50Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.26364253
51Other glycan degradation_Homo sapiens_hsa005111.25330806
52DNA replication_Homo sapiens_hsa030301.24670209
53Huntingtons disease_Homo sapiens_hsa050161.23805955
54Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.18105140
55beta-Alanine metabolism_Homo sapiens_hsa004101.17867062
56Pentose phosphate pathway_Homo sapiens_hsa000301.14843129
57PPAR signaling pathway_Homo sapiens_hsa033201.13290018
58Alzheimers disease_Homo sapiens_hsa050101.12503369
59Sulfur metabolism_Homo sapiens_hsa009201.12129966
60Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.10952223
61N-Glycan biosynthesis_Homo sapiens_hsa005101.08502822
62Bile secretion_Homo sapiens_hsa049761.07239978
63Peroxisome_Homo sapiens_hsa041461.06302492
64Carbon metabolism_Homo sapiens_hsa012001.03915640
65Starch and sucrose metabolism_Homo sapiens_hsa005001.03013591
66Staphylococcus aureus infection_Homo sapiens_hsa051501.02129216
67Steroid biosynthesis_Homo sapiens_hsa001001.00038883
68Steroid hormone biosynthesis_Homo sapiens_hsa001400.98033521
69p53 signaling pathway_Homo sapiens_hsa041150.95391279
70Galactose metabolism_Homo sapiens_hsa000520.94787922
71Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.94666310
72Circadian rhythm_Homo sapiens_hsa047100.92810280
73Phenylalanine metabolism_Homo sapiens_hsa003600.90756600
74RNA transport_Homo sapiens_hsa030130.90684665
75Ether lipid metabolism_Homo sapiens_hsa005650.87962200
76Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.85902668
77One carbon pool by folate_Homo sapiens_hsa006700.85791702
78Purine metabolism_Homo sapiens_hsa002300.84464819
79Glycerophospholipid metabolism_Homo sapiens_hsa005640.84447031
80Protein digestion and absorption_Homo sapiens_hsa049740.81431381
81Propanoate metabolism_Homo sapiens_hsa006400.81259714
82Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.81103084
83Glycerolipid metabolism_Homo sapiens_hsa005610.79887048
84Sphingolipid metabolism_Homo sapiens_hsa006000.78601518
85ABC transporters_Homo sapiens_hsa020100.78242977
86Intestinal immune network for IgA production_Homo sapiens_hsa046720.77647651
87Cyanoamino acid metabolism_Homo sapiens_hsa004600.76580012
88Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.72885766
89Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.71246619
90Protein export_Homo sapiens_hsa030600.70886256
91Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.70354294
92Asthma_Homo sapiens_hsa053100.69211808
93Fatty acid elongation_Homo sapiens_hsa000620.68620973
94Nucleotide excision repair_Homo sapiens_hsa034200.67016016
95mTOR signaling pathway_Homo sapiens_hsa041500.64840896
96Pyruvate metabolism_Homo sapiens_hsa006200.64308181
97Tyrosine metabolism_Homo sapiens_hsa003500.62639227
98Lysine degradation_Homo sapiens_hsa003100.62481205
99Adherens junction_Homo sapiens_hsa045200.61659981
100Bladder cancer_Homo sapiens_hsa052190.61410881
101Hippo signaling pathway_Homo sapiens_hsa043900.58613256
102Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.55203412
103Renin-angiotensin system_Homo sapiens_hsa046140.55071887
104Proteasome_Homo sapiens_hsa030500.52318099
105Metabolic pathways_Homo sapiens_hsa011000.51075431
106Spliceosome_Homo sapiens_hsa030400.50392145
107SNARE interactions in vesicular transport_Homo sapiens_hsa041300.46643247
108Carbohydrate digestion and absorption_Homo sapiens_hsa049730.46572042
109Cell cycle_Homo sapiens_hsa041100.44414585
110Glycosaminoglycan degradation_Homo sapiens_hsa005310.44194614
111Hedgehog signaling pathway_Homo sapiens_hsa043400.41572043
112Pyrimidine metabolism_Homo sapiens_hsa002400.41178155
113Primary immunodeficiency_Homo sapiens_hsa053400.40777544
114Tight junction_Homo sapiens_hsa045300.40034441
115Longevity regulating pathway - mammal_Homo sapiens_hsa042110.39256937
116Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.38796363
117RNA polymerase_Homo sapiens_hsa030200.38697969
118Notch signaling pathway_Homo sapiens_hsa043300.38431653
119Linoleic acid metabolism_Homo sapiens_hsa005910.38085774
120* Mineral absorption_Homo sapiens_hsa049780.36781612
121alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.33796546
122Regulation of autophagy_Homo sapiens_hsa041400.33030827
123Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.31175219
124Homologous recombination_Homo sapiens_hsa034400.31105093
125Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.25994797

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