SLC39A5

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene belongs to the ZIP family of zinc transporters that transport zinc into cells from outside, and play a crucial role in controlling intracellular zinc levels. Zinc is an essential cofactor for many enzymes and proteins involved in gene transcription, growth, development and differentiation. Mutations in this gene have been associated with autosomal dominant high myopia (MYP24). Alternatively spliced transcript variants have been found for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1digestion (GO:0007586)9.88646294
2intestinal absorption (GO:0050892)8.28314936
3protein retention in ER lumen (GO:0006621)7.87140480
4angiotensin maturation (GO:0002003)7.83330364
5epoxygenase P450 pathway (GO:0019373)7.37465585
6maintenance of protein localization in endoplasmic reticulum (GO:0035437)7.27285926
7regulation of systemic arterial blood pressure by renin-angiotensin (GO:0003081)7.12126532
8cysteine metabolic process (GO:0006534)6.83205416
9transcytosis (GO:0045056)6.27756479
10cobalamin metabolic process (GO:0009235)6.21954472
11very-low-density lipoprotein particle assembly (GO:0034379)6.02376824
12negative regulation of digestive system process (GO:0060457)5.66871205
13NADH metabolic process (GO:0006734)5.55747739
14fat-soluble vitamin biosynthetic process (GO:0042362)5.54721988
15regulation of bile acid biosynthetic process (GO:0070857)5.40066561
16regulation of guanylate cyclase activity (GO:0031282)5.38577083
17drug metabolic process (GO:0017144)5.37333113
18urea metabolic process (GO:0019627)5.16048982
19lipoprotein transport (GO:0042953)5.14216358
20homocysteine metabolic process (GO:0050667)5.11701041
21urea cycle (GO:0000050)5.08011443
22cellular modified amino acid catabolic process (GO:0042219)5.00391893
23proline biosynthetic process (GO:0006561)4.97950120
24cholesterol catabolic process (GO:0006707)4.96777743
25sterol catabolic process (GO:0016127)4.96777743
26serine family amino acid biosynthetic process (GO:0009070)4.95742057
27exogenous drug catabolic process (GO:0042738)4.90069671
28cellular glucuronidation (GO:0052695)4.83239688
29diacylglycerol metabolic process (GO:0046339)4.82667959
30fructose metabolic process (GO:0006000)4.78990436
31L-phenylalanine catabolic process (GO:0006559)4.78450888
32erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)4.78450888
33L-phenylalanine metabolic process (GO:0006558)4.74544056
34erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)4.74544056
35uronic acid metabolic process (GO:0006063)4.74159047
36glucuronate metabolic process (GO:0019585)4.74159047
37branched-chain amino acid catabolic process (GO:0009083)4.71389284
38hormone catabolic process (GO:0042447)4.71245341
39nitrogen cycle metabolic process (GO:0071941)4.69774703
40bile acid and bile salt transport (GO:0015721)4.68766229
41aspartate family amino acid catabolic process (GO:0009068)4.61597805
42ethanol oxidation (GO:0006069)4.55117443
43plasma lipoprotein particle organization (GO:0071827)4.39578821
44endocrine process (GO:0050886)4.39119342
45regulation of systemic arterial blood pressure by hormone (GO:0001990)4.39119342
46regulation of systemic arterial blood pressure mediated by a chemical signal (GO:0003044)4.39119342
47peptidyl-proline hydroxylation (GO:0019511)4.33377534
48cholesterol efflux (GO:0033344)4.32094654
49regulation of phospholipase A2 activity (GO:0032429)4.29334405
50triglyceride-rich lipoprotein particle remodeling (GO:0034370)4.28453883
51proline metabolic process (GO:0006560)4.27498437
52branched-chain amino acid metabolic process (GO:0009081)4.18903442
53serine family amino acid metabolic process (GO:0009069)4.15349447
54protein-lipid complex subunit organization (GO:0071825)4.14414472
55sulfur amino acid catabolic process (GO:0000098)4.13124503
56low-density lipoprotein particle remodeling (GO:0034374)4.09703663
57bile acid metabolic process (GO:0008206)4.07900208
58omega-hydroxylase P450 pathway (GO:0097267)4.06407134
59glycolipid catabolic process (GO:0019377)4.04464775
60alkaloid metabolic process (GO:0009820)4.02166485
61valine metabolic process (GO:0006573)4.00207026
62negative regulation of cholesterol transport (GO:0032375)3.99580549
63negative regulation of sterol transport (GO:0032372)3.99580549
64lysine catabolic process (GO:0006554)3.96396958
65lysine metabolic process (GO:0006553)3.96396958
66positive regulation of guanylate cyclase activity (GO:0031284)3.95582107
67arginine metabolic process (GO:0006525)3.89261353
68membrane lipid catabolic process (GO:0046466)3.87631829
69regulation of systemic arterial blood pressure (GO:0003073)3.85643708
70positive regulation of lipid catabolic process (GO:0050996)3.84980980
71renal system process involved in regulation of blood volume (GO:0001977)3.82395472
72fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)3.81882742
73regulation of cholesterol homeostasis (GO:2000188)3.80353164
74cholesterol transport (GO:0030301)3.78861308
75sterol transport (GO:0015918)3.78861308
764-hydroxyproline metabolic process (GO:0019471)3.77026114
77intestinal epithelial cell development (GO:0060576)3.76568603
78regulation of protein activation cascade (GO:2000257)3.74444409
79antibacterial humoral response (GO:0019731)3.67955095
80renal system process involved in regulation of systemic arterial blood pressure (GO:0003071)3.67651583
81leukotriene biosynthetic process (GO:0019370)3.64655609
82ethanol metabolic process (GO:0006067)3.62842261
83regulation of complement activation (GO:0030449)3.57121848
84negative regulation of fibrinolysis (GO:0051918)3.57107315
85short-chain fatty acid metabolic process (GO:0046459)3.53199802
86positive regulation of triglyceride lipase activity (GO:0061365)3.52614663
87positive regulation of lipoprotein lipase activity (GO:0051006)3.52614663
88positive regulation of fatty acid biosynthetic process (GO:0045723)3.51016984
89regulation of fibrinolysis (GO:0051917)3.49854853
90peptidyl-glutamic acid carboxylation (GO:0017187)3.49716564
91protein carboxylation (GO:0018214)3.49716564
92complement activation, classical pathway (GO:0006958)3.49333056
93phenylpropanoid metabolic process (GO:0009698)3.49072015
94GDP-mannose metabolic process (GO:0019673)3.46683015
95reverse cholesterol transport (GO:0043691)3.46359250
96complement activation, alternative pathway (GO:0006957)3.45843748
97glyoxylate metabolic process (GO:0046487)3.45218765
98antimicrobial humoral response (GO:0019730)3.44924869
99mitochondrial calcium ion transport (GO:0006851)3.44402008
100drug transport (GO:0015893)3.40475170
101L-serine metabolic process (GO:0006563)3.39820401
102vitamin transmembrane transport (GO:0035461)3.38696881
103regulation of digestive system process (GO:0044058)3.37019642
104digestive system process (GO:0022600)3.35231459
105maintenance of gastrointestinal epithelium (GO:0030277)3.32808994
106regulation of cGMP biosynthetic process (GO:0030826)3.31513021
107glycine metabolic process (GO:0006544)3.30727859
108coenzyme catabolic process (GO:0009109)3.30247112
109cellular amino acid catabolic process (GO:0009063)3.28908301
110ceramide catabolic process (GO:0046514)3.28802610
111regulation of cellular extravasation (GO:0002691)3.27945217
112vitamin transport (GO:0051180)3.25527174
113L-ascorbic acid metabolic process (GO:0019852)3.25366721
114vitamin biosynthetic process (GO:0009110)3.25288519
115peptide catabolic process (GO:0043171)3.23268148
116peptide hormone processing (GO:0016486)3.21424487
117high-density lipoprotein particle remodeling (GO:0034375)3.20560673
118receptor guanylyl cyclase signaling pathway (GO:0007168)3.20439822
119acylglycerol homeostasis (GO:0055090)3.19513309
120triglyceride homeostasis (GO:0070328)3.19513309
121galactose catabolic process (GO:0019388)3.16620204
122aromatic amino acid family catabolic process (GO:0009074)3.14670261
123phospholipid efflux (GO:0033700)3.09246723
124protein-lipid complex remodeling (GO:0034368)3.07335445
125macromolecular complex remodeling (GO:0034367)3.07335445
126plasma lipoprotein particle remodeling (GO:0034369)3.07335445
127nonribosomal peptide biosynthetic process (GO:0019184)3.06817236
128complement activation (GO:0006956)3.06700054
129regulation of cholesterol metabolic process (GO:0090181)3.06486900
130glutamine family amino acid biosynthetic process (GO:0009084)3.06409497
131protein hydroxylation (GO:0018126)3.05934498
132protein activation cascade (GO:0072376)3.05701754
133creatine metabolic process (GO:0006600)3.05194595
134endocrine pancreas development (GO:0031018)3.04865101
135drinking behavior (GO:0042756)3.04473241
136UDP-N-acetylglucosamine metabolic process (GO:0006047)3.03938462
137serine family amino acid catabolic process (GO:0009071)3.03558857
138regulation of cholesterol esterification (GO:0010872)3.03088038
139plasma lipoprotein particle assembly (GO:0034377)3.02454441
140glutathione derivative metabolic process (GO:1901685)3.00385206
141glutathione derivative biosynthetic process (GO:1901687)3.00385206
142urate metabolic process (GO:0046415)3.00337303
143alpha-amino acid catabolic process (GO:1901606)3.00313047
144steroid catabolic process (GO:0006706)2.99168533
145glutathione biosynthetic process (GO:0006750)2.98519441
146glutamate metabolic process (GO:0006536)2.96501550
147carboxylic acid catabolic process (GO:0046395)2.96384609
148organic acid catabolic process (GO:0016054)2.96384609
149mitochondrial ATP synthesis coupled proton transport (GO:0042776)2.95306498
150lipoprotein metabolic process (GO:0042157)2.95211582
151sulfur amino acid biosynthetic process (GO:0000097)2.94544275
152regulation of triglyceride catabolic process (GO:0010896)2.94027166
153tetrapyrrole metabolic process (GO:0033013)2.93869532
154innate immune response in mucosa (GO:0002227)2.93200301
155cholesterol homeostasis (GO:0042632)2.92399281
156signal peptide processing (GO:0006465)2.90483476
157sterol homeostasis (GO:0055092)2.90450107
158flavonoid metabolic process (GO:0009812)2.86307780
159fatty acid catabolic process (GO:0009062)2.85575651
160protein-lipid complex assembly (GO:0065005)2.81592086
161drug catabolic process (GO:0042737)2.79016035
162sulfur amino acid metabolic process (GO:0000096)2.78575105
163alpha-amino acid biosynthetic process (GO:1901607)2.78381590
164cellular ketone body metabolic process (GO:0046950)2.77929070
165biotin metabolic process (GO:0006768)2.77056510
166drug transmembrane transport (GO:0006855)2.76075984
167positive regulation of heat generation (GO:0031652)2.73879372
168regulation of fever generation (GO:0031620)2.72150795
169intestinal cholesterol absorption (GO:0030299)13.5988793
170exocrine pancreas development (GO:0031017)10.6753343

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1ESR1_17901129_ChIP-ChIP_LIVER_Mouse7.25137947
2TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat5.23572744
3RXR_22158963_ChIP-Seq_LIVER_Mouse4.61421763
4PPARA_22158963_ChIP-Seq_LIVER_Mouse4.46588969
5LXR_22158963_ChIP-Seq_LIVER_Mouse3.82108073
6FOXO1_23066095_ChIP-Seq_LIVER_Mouse3.22422742
7SOX9_22984422_ChIP-ChIP_TESTIS_Rat3.19987343
8PPARG_19300518_ChIP-PET_3T3-L1_Mouse3.19884788
9* HNF4A_19761587_ChIP-ChIP_CACO-2_Human3.04650795
10IRF1_21803131_ChIP-Seq_MONOCYTES_Human2.97838580
11GATA4_25053715_ChIP-Seq_YYC3_Human2.95697500
12CDX2_20551321_ChIP-Seq_CACO-2_Human2.86120347
13CEBPA_23403033_ChIP-Seq_LIVER_Mouse2.81298666
14FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.76724600
15SOX2_27498859_Chip-Seq_STOMACH_Mouse2.72967792
16ERG_21242973_ChIP-ChIP_JURKAT_Human2.69382123
17TP63_17297297_ChIP-ChIP_HaCaT_Human2.58243900
18STAT6_21828071_ChIP-Seq_BEAS2B_Human2.56785831
19EGR1_23403033_ChIP-Seq_LIVER_Mouse2.55912634
20GATA6_25053715_ChIP-Seq_YYC3_Human2.18643474
21STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse2.11958919
22PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.87102926
23MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.85606594
24IRF8_22096565_ChIP-ChIP_GC-B_Human1.85041478
25SOX2_20726797_ChIP-Seq_SW620_Human1.79581357
26THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.79345821
27ESR2_21235772_ChIP-Seq_MCF-7_Human1.73243821
28CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.69604139
29RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.69261048
30BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.68069164
31ESR1_21235772_ChIP-Seq_MCF-7_Human1.62837394
32CDX2_19796622_ChIP-Seq_MESCs_Mouse1.62360451
33PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse1.60305749
34FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.58513293
35PPARD_23208498_ChIP-Seq_MDA-MB-231_Human1.56945915
36BP1_19119308_ChIP-ChIP_Hs578T_Human1.54564666
37TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.50047075
38ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.47907775
39CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.46616938
40BMI1_19503595_ChIP-Seq_MEFsC_Mouse1.45721549
41GATA1_22025678_ChIP-Seq_K562_Human1.38068316
42EGR1_19032775_ChIP-ChIP_M12_Human1.36633559
43PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse1.36236602
44NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.36001002
45NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.35532797
46NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.32564795
47TCF4_18268006_ChIP-ChIP_LS174T_Human1.30823960
48TAF2_19829295_ChIP-Seq_ESCs_Human1.29550243
49FOXA2_19822575_ChIP-Seq_HepG2_Human1.22489304
50SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.21622240
51IRF1_19129219_ChIP-ChIP_H3396_Human1.19472873
52TET1_21451524_ChIP-Seq_MESCs_Mouse1.16785453
53CTCF_27219007_Chip-Seq_Bcells_Human1.16706494
54KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.16423438
55KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.16423438
56KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.16423438
57LXR_22292898_ChIP-Seq_THP-1_Human1.16026583
58HNF4A_19822575_ChIP-Seq_HepG2_Human1.15766171
59* SMAD2/3_21741376_ChIP-Seq_ESCs_Human1.13897808
60SA1_27219007_Chip-Seq_ERYTHROID_Human1.11881887
61* BCL6_27268052_Chip-Seq_Bcells_Human1.11033877
62ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.08686129
63PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.06246397
64SRY_22984422_ChIP-ChIP_TESTIS_Rat1.05355364
65CLOCK_20551151_ChIP-Seq_293T_Human1.05143247
66CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.04358894
67P63_26484246_Chip-Seq_KERATINOCYTES_Human1.02889664
68ESET_19884257_ChIP-Seq_ESCs_Mouse1.02093703
69FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human1.01986130
70PPAR_26484153_Chip-Seq_NCI-H1993_Human1.00530746
71* SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.99841521
72CREB1_26743006_Chip-Seq_LNCaP_Human0.97869119
73CTCF_20526341_ChIP-Seq_ESCs_Human0.97072601
74NANOG_20526341_ChIP-Seq_ESCs_Human0.96869353
75AR_21915096_ChIP-Seq_LNCaP-1F5_Human0.96506585
76SA1_27219007_Chip-Seq_Bcells_Human0.96489386
77DNAJC2_21179169_ChIP-ChIP_NT2_Human0.96267547
78KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human0.94224473
79ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.92550837
80MYC_19915707_ChIP-ChIP_AK7_Human0.91967652
81CDX2_22108803_ChIP-Seq_LS180_Human0.90678507
82SOX3_22085726_ChIP-Seq_MUSCLE_Mouse0.90407046
83RARG_19884340_ChIP-ChIP_MEFs_Mouse0.90315065
84STAT1_20625510_ChIP-Seq_HELA_Human0.89903972
85CHD7_19251738_ChIP-ChIP_MESCs_Mouse0.89896791
86TP63_22573176_ChIP-Seq_HFKS_Human0.89398291
87FOXA1_25552417_ChIP-Seq_VCAP_Human0.89354993
88* ERA_21632823_ChIP-Seq_H3396_Human0.89090366
89SOX2_22085726_ChIP-Seq_NPCs_Mouse0.88952646
90RACK7_27058665_Chip-Seq_MCF-7_Human0.88920687
91ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.88557447
92RUNX1_27514584_Chip-Seq_MCF-7_Human0.88153491
93CEBPB_22108803_ChIP-Seq_LS180_Human0.87477998
94RAD21_21589869_ChIP-Seq_MESCs_Mouse0.87361204
95AR_20517297_ChIP-Seq_VCAP_Human0.87078301
96E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human0.86434435
97ERG_20517297_ChIP-Seq_VCAP_Human0.86051641
98ESR1_15608294_ChIP-ChIP_MCF-7_Human0.85777216
99OCT4_20526341_ChIP-Seq_ESCs_Human0.85660317
100JARID1B-DAIN_22020125_ChIP-Seq_ESCs_Mouse0.85551438
101EBNA1_20929547_Chip-Seq_RAJI-cells_Human0.85056550
102TCF7L2_21901280_ChIP-Seq_H4IIE_Rat0.84931217
103TRIM28_21343339_ChIP-Seq_HEK293_Human0.84717538
104KAP1_22055183_ChIP-Seq_ESCs_Mouse0.84239822
105FOXO3_23340844_ChIP-Seq_DLD1_Human0.84045699
106ZNF263_19887448_ChIP-Seq_K562_Human0.83844012
107* P68_20966046_ChIP-Seq_HELA_Human0.82601694
108GATA2_20887958_ChIP-Seq_HPC-7_Mouse0.81964436
109* E2F1_20622854_ChIP-Seq_HELA_Human0.81868156
110MYC_19829295_ChIP-Seq_ESCs_Human0.81180746
111ATF3_27146783_Chip-Seq_COLON_Human0.80794650
112RARA_24833708_ChIP-Seq_LIVER_Mouse0.80766342
113GATA2_19941826_ChIP-Seq_K562_Human0.80551808
114SOX2_21211035_ChIP-Seq_LN229_Human0.79530817
115ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human0.79134275
116P300_27268052_Chip-Seq_Bcells_Human0.78915335
117PBX1_22567123_ChIP-ChIP_OVCAR3_Human0.78803285
118SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse0.78497193
119GATA1_19941826_ChIP-Seq_K562_Human0.78141123
120HTT_18923047_ChIP-ChIP_STHdh_Human0.77965799
121DROSHA_22980978_ChIP-Seq_HELA_Human0.77874404
122KLF5_25053715_ChIP-Seq_YYC3_Human0.77760611
123NR4A2_19515692_ChIP-ChIP_MN9D_Mouse0.77649934
124* PHF8_20622854_ChIP-Seq_HELA_Human0.77507069
125* P53_21459846_ChIP-Seq_SAOS-2_Human0.76860814
126RXR_22108803_ChIP-Seq_LS180_Human0.76576490
127P63_20808887_ChIP-Seq_KERATINOCYTES_Human0.76213082
128TFAP2C_20629094_ChIP-Seq_MCF-7_Human0.76171446
129* BCOR_27268052_Chip-Seq_Bcells_Human0.75446185
130CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human0.74040093
131CTCF_18555785_ChIP-Seq_MESCs_Mouse0.73856601
132CREB1_26743006_Chip-Seq_LNCaP-abl_Human0.73656584
133TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.73004196
134* SREBP2_21459322_ChIP-Seq_LIVER_Mouse0.72560262
135GATA3_24758297_ChIP-Seq_MCF-7_Human0.70496597

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0001666_abnormal_nutrient_absorption8.31068012
2MP0005083_abnormal_biliary_tract7.06574263
3MP0005365_abnormal_bile_salt6.22358985
4MP0005360_urolithiasis5.26965739
5MP0005220_abnormal_exocrine_pancreas4.63036397
6MP0005085_abnormal_gallbladder_physiolo4.36191491
7MP0005084_abnormal_gallbladder_morpholo4.15990832
8MP0002139_abnormal_hepatobiliary_system4.08451050
9MP0003868_abnormal_feces_composition3.80077092
10MP0004264_abnormal_extraembryonic_tissu2.66569734
11MP0001664_abnormal_digestion2.39619965
12MP0005332_abnormal_amino_acid2.37733561
13MP0005451_abnormal_body_composition2.36984477
14MP0008875_abnormal_xenobiotic_pharmacok2.02327819
15MP0010329_abnormal_lipoprotein_level1.99911780
16MP0004019_abnormal_vitamin_homeostasis1.92660507
17MP0003252_abnormal_bile_duct1.88298140
18MP0005409_darkened_coat_color1.78668153
19MP0003959_abnormal_lean_body1.73200832
20MP0009643_abnormal_urine_homeostasis1.70068288
21MP0002118_abnormal_lipid_homeostasis1.66449791
22MP0003806_abnormal_nucleotide_metabolis1.62100862
23MP0002693_abnormal_pancreas_physiology1.61758251
24MP0003191_abnormal_cellular_cholesterol1.59372051
25MP0005670_abnormal_white_adipose1.56649788
26MP0001873_stomach_inflammation1.54453127
27MP0010234_abnormal_vibrissa_follicle1.53681495
28MP0005448_abnormal_energy_balance1.46320747
29MP0009840_abnormal_foam_cell1.43324969
30MP0001663_abnormal_digestive_system1.41163039
31MP0002277_abnormal_respiratory_mucosa1.40220181
32MP0003638_abnormal_response/metabolism_1.38171384
33MP0003879_abnormal_hair_cell1.33592041
34MP0002138_abnormal_hepatobiliary_system1.29692991
35MP0003705_abnormal_hypodermis_morpholog1.28353008
36MP0001764_abnormal_homeostasis1.28263404
37MP0005381_digestive/alimentary_phenotyp1.24572717
38MP0004043_abnormal_pH_regulation1.24189202
39MP0005636_abnormal_mineral_homeostasis1.19609424
40MP0000490_abnormal_crypts_of1.15254494
41MP0000678_abnormal_parathyroid_gland1.11630975
42MP0005166_decreased_susceptibility_to1.07400336
43MP0004147_increased_porphyrin_level1.06601062
44MP0000462_abnormal_digestive_system1.05945861
45MP0000566_synostosis1.05932351
46MP0001944_abnormal_pancreas_morphology1.05365447
47MP0005408_hypopigmentation1.04093643
48MP0005165_increased_susceptibility_to1.00997522
49MP0003718_maternal_effect0.98080054
50MP0000609_abnormal_liver_physiology0.96699935
51MP0008004_abnormal_stomach_pH0.96088846
52MP0010352_gastrointestinal_tract_polyps0.95883401
53MP0004782_abnormal_surfactant_physiolog0.95357627
54MP0002971_abnormal_brown_adipose0.94990873
55MP0003878_abnormal_ear_physiology0.94481589
56MP0005377_hearing/vestibular/ear_phenot0.94481589
57MP0001765_abnormal_ion_homeostasis0.91354078
58MP0005319_abnormal_enzyme/_coenzyme0.90047059
59MP0002796_impaired_skin_barrier0.88124165
60MP0003656_abnormal_erythrocyte_physiolo0.87642067
61MP0000470_abnormal_stomach_morphology0.87320929
62MP0008872_abnormal_physiological_respon0.87093509
63MP0003186_abnormal_redox_activity0.86777909
64MP0002078_abnormal_glucose_homeostasis0.85526727
65MP0004858_abnormal_nervous_system0.85289014
66MP0006036_abnormal_mitochondrial_physio0.85268415
67MP0002876_abnormal_thyroid_physiology0.83137122
68MP0005535_abnormal_body_temperature0.82258326
69MP0009379_abnormal_foot_pigmentation0.79997907
70MP0001756_abnormal_urination0.78852095
71MP0009765_abnormal_xenobiotic_induced0.75841126
72MP0001188_hyperpigmentation0.75261539
73MP0010155_abnormal_intestine_physiology0.74421703
74MP0009115_abnormal_fat_cell0.74357795
75MP0009697_abnormal_copulation0.70947705
76MP0005584_abnormal_enzyme/coenzyme_acti0.69685948
77MP0002089_abnormal_postnatal_growth/wei0.68668603
78MP0009384_cardiac_valve_regurgitation0.68579424
79MP0003953_abnormal_hormone_level0.67109084
80MP0004270_analgesia0.66842093
81MP0000598_abnormal_liver_morphology0.64615807
82MP0002136_abnormal_kidney_physiology0.63933985
83MP0004233_abnormal_muscle_weight0.63365591
84MP0000538_abnormal_urinary_bladder0.62678497
85MP0002098_abnormal_vibrissa_morphology0.62271940
86MP0003195_calcinosis0.61234739
87MP0009642_abnormal_blood_homeostasis0.60783187
88MP0005058_abnormal_lysosome_morphology0.59667797
89MP0003866_abnormal_defecation0.59209405
90MP0003329_amyloid_beta_deposits0.57917993
91MP0009785_altered_susceptibility_to0.57475276
92MP0000249_abnormal_blood_vessel0.56845057
93MP0000604_amyloidosis0.55209203
94MP0001501_abnormal_sleep_pattern0.55014657
95MP0005666_abnormal_adipose_tissue0.54612925
96MP0001845_abnormal_inflammatory_respons0.50835980
97MP0000613_abnormal_salivary_gland0.49919170
98MP0003183_abnormal_peptide_metabolism0.46639267
99MP0002132_abnormal_respiratory_system0.46222637
100MP0008469_abnormal_protein_level0.46100664
101MP0009764_decreased_sensitivity_to0.45905946
102MP0002166_altered_tumor_susceptibility0.44796217
103MP0005395_other_phenotype0.44430538
104MP0005025_abnormal_response_to0.41459729
105MP0008789_abnormal_olfactory_epithelium0.41398930
106MP0000477_abnormal_intestine_morphology0.41335498
107MP0000537_abnormal_urethra_morphology0.40892144
108MP0003436_decreased_susceptibility_to0.40820520
109MP0002822_catalepsy0.38530818
110MP0005334_abnormal_fat_pad0.36743615
111MP0000230_abnormal_systemic_arterial0.36272620
112MP0000003_abnormal_adipose_tissue0.36119984
113MP0002896_abnormal_bone_mineralization0.35986769
114MP0006054_spinal_hemorrhage0.35962732
115MP0005452_abnormal_adipose_tissue0.35868950
116MP0002249_abnormal_larynx_morphology0.35535281
117MP0009763_increased_sensitivity_to0.33426345
118MP0006035_abnormal_mitochondrial_morpho0.32570149
119MP0005501_abnormal_skin_physiology0.31950908
120MP0006082_CNS_inflammation0.31717997
121MP0005376_homeostasis/metabolism_phenot0.30693369
122MP0004185_abnormal_adipocyte_glucose0.28866023
123MP0002928_abnormal_bile_duct0.28589253
124MP0002069_abnormal_eating/drinking_beha0.28542225
125MP0000467_abnormal_esophagus_morphology0.28457195
126MP0002254_reproductive_system_inflammat0.27998093
127MP0002135_abnormal_kidney_morphology0.27940360
128MP0001731_abnormal_postnatal_growth0.27917021
129MP0001485_abnormal_pinna_reflex0.26825338
130MP0009333_abnormal_splenocyte_physiolog0.26659435
131MP0003300_gastrointestinal_ulcer0.26008011

Predicted human phenotypes

RankGene SetZ-score
1Fat malabsorption (HP:0002630)5.84836880
2Steatorrhea (HP:0002570)5.52263226
3Systemic lupus erythematosus (HP:0002725)5.44479354
4Gout (HP:0001997)5.03754148
5Complement deficiency (HP:0004431)4.89401010
6Abnormality of aromatic amino acid family metabolism (HP:0004338)4.67124704
7Hyperglycinuria (HP:0003108)4.46105596
8Abnormality of complement system (HP:0005339)4.14388864
9Widely patent fontanelles and sutures (HP:0004492)4.05541423
10Abnormality of serine family amino acid metabolism (HP:0010894)4.03659361
11Abnormality of glycine metabolism (HP:0010895)4.03659361
12Prolonged partial thromboplastin time (HP:0003645)4.01552135
13Ketosis (HP:0001946)3.95932457
14Abnormality of glutamine family amino acid metabolism (HP:0010902)3.85975445
15Short chin (HP:0000331)3.84620793
16Abnormality of sulfur amino acid metabolism (HP:0004339)3.73843159
17Glomerulonephritis (HP:0000099)3.73297830
18Hemorrhage of the eye (HP:0011885)3.72453204
19Decreased subcutaneous fat (HP:0001002)3.72113953
20Abnormality of aspartate family amino acid metabolism (HP:0010899)3.63103549
21Pancreatitis (HP:0001733)3.59397374
22Hyperglycinemia (HP:0002154)3.56548552
23Ileus (HP:0002595)3.52650620
24Ketoacidosis (HP:0001993)3.48948926
25Abnormality of the intrinsic pathway (HP:0010989)3.48000232
26Chronic diarrhea (HP:0002028)3.47394005
27Hypoglycemic coma (HP:0001325)3.46489128
28Hypobetalipoproteinemia (HP:0003563)3.38000885
29Type I diabetes mellitus (HP:0100651)3.37984541
30Abnormality of subcutaneous fat tissue (HP:0001001)3.26062521
31Joint hemorrhage (HP:0005261)3.25396597
32Acute encephalopathy (HP:0006846)3.23059977
33Pigmentary retinal degeneration (HP:0001146)3.21395814
34Increased purine levels (HP:0004368)3.21346420
35Hyperuricemia (HP:0002149)3.21346420
36Facial shape deformation (HP:0011334)3.20219277
37Potter facies (HP:0002009)3.20219277
38Hyperammonemia (HP:0001987)3.19773967
39Malnutrition (HP:0004395)3.17557507
40Proximal tubulopathy (HP:0000114)3.16741731
41Glycosuria (HP:0003076)3.13073094
42Abnormality of urine glucose concentration (HP:0011016)3.13073094
43Exocrine pancreatic insufficiency (HP:0001738)3.10320288
44Abnormality of pyrimidine metabolism (HP:0004353)3.09989691
45Nausea (HP:0002018)3.01806775
46Intrahepatic cholestasis (HP:0001406)3.00642342
47Epidermoid cyst (HP:0200040)2.97296610
48Wide cranial sutures (HP:0010537)2.92939258
49Cerebral edema (HP:0002181)2.92107572
50Abnormality of dicarboxylic acid metabolism (HP:0010995)2.87487128
51Dicarboxylic aciduria (HP:0003215)2.87487128
52Acanthocytosis (HP:0001927)2.84542999
53Abnormality of fatty-acid metabolism (HP:0004359)2.84224036
54Abnormality of purine metabolism (HP:0004352)2.83950922
55Decreased circulating renin level (HP:0003351)2.83811090
56Lethargy (HP:0001254)2.82687739
57Nephrolithiasis (HP:0000787)2.79055757
58Hyperlipoproteinemia (HP:0010980)2.78708930
59Xanthomatosis (HP:0000991)2.76171904
60Nephritis (HP:0000123)2.73253862
61Abnormality of the common coagulation pathway (HP:0010990)2.72816215
62Abnormality of the vitamin B12 metabolism (HP:0004341)2.68278737
63Hypophosphatemia (HP:0002148)2.64502720
64Abnormality of monocarboxylic acid metabolism (HP:0010996)2.63888733
65Metabolic acidosis (HP:0001942)2.63029290
66Abnormal urine phosphate concentration (HP:0012599)2.62727565
67Hepatic necrosis (HP:0002605)2.62674498
68Abnormality of vitamin B metabolism (HP:0004340)2.60772123
69Maternal diabetes (HP:0009800)2.59167380
70Hypolipoproteinemia (HP:0010981)2.58056377
71Vascular calcification (HP:0004934)2.56653095
72Metabolic alkalosis (HP:0200114)2.54576147
73Thin bony cortex (HP:0002753)2.54108244
74Megaloblastic anemia (HP:0001889)2.53898879
75Abnormality of methionine metabolism (HP:0010901)2.53037546
76Reduced antithrombin III activity (HP:0001976)2.51640295
77Conjugated hyperbilirubinemia (HP:0002908)2.51126890
78Abnormal tarsal ossification (HP:0008369)2.46206256
79Congenital sensorineural hearing impairment (HP:0008527)2.45743644
80Methylmalonic aciduria (HP:0012120)2.45580385
81Hypoglycemic seizures (HP:0002173)2.44737147
82Vomiting (HP:0002013)2.43519044
83Generalized aminoaciduria (HP:0002909)2.42423438
84Abnormality of renin-angiotensin system (HP:0000847)2.38608015
85Confusion (HP:0001289)2.35021665
86Acute necrotizing encephalopathy (HP:0006965)2.33044445
87Abnormality of renal excretion (HP:0011036)2.32294933
88Prenatal maternal abnormality (HP:0002686)2.31681748
89Hypoplasia of the pons (HP:0012110)2.31323071
90Hepatocellular necrosis (HP:0001404)2.29169215
91Hypotension (HP:0002615)2.28625106
92Spontaneous abortion (HP:0005268)2.28274540
93Hyperactive renin-angiotensin system (HP:0000841)2.27377419
94Hydroxyprolinuria (HP:0003080)2.27288693
95Abnormality of proline metabolism (HP:0010907)2.27288693
96Abnormal mitochondria in muscle tissue (HP:0008316)2.24776498
97Mitochondrial inheritance (HP:0001427)2.24523038
98Opisthotonus (HP:0002179)2.23971147
99Abnormality of vitamin metabolism (HP:0100508)2.23804765
100Abnormality of the pons (HP:0007361)2.23466766
101Symptomatic seizures (HP:0011145)2.23278030
102Cardiovascular calcification (HP:0011915)2.22881241
103Abnormality of nucleobase metabolism (HP:0010932)2.22251048
104Deep venous thrombosis (HP:0002625)2.20493964
105Vacuolated lymphocytes (HP:0001922)2.19871787
106Abnormality of long-chain fatty-acid metabolism (HP:0010964)2.19745321
107Abdominal distention (HP:0003270)2.18702983
108Flat acetabular roof (HP:0003180)2.17607504
109Abnormality of the level of lipoprotein cholesterol (HP:0010979)2.15842428
110Hypercholesterolemia (HP:0003124)2.13949484
111Delayed epiphyseal ossification (HP:0002663)2.13585904
112Late onset (HP:0003584)2.12805949
113Abnormal pancreas size (HP:0012094)2.12101911
114Hyperphosphaturia (HP:0003109)2.11852421
115Delayed CNS myelination (HP:0002188)2.08792307
116Focal segmental glomerulosclerosis (HP:0000097)2.07608240
117Cerebral palsy (HP:0100021)2.07126759
118Abnormality of the pancreatic islet cells (HP:0006476)2.06713443
119Abnormality of endocrine pancreas physiology (HP:0012093)2.06713443
120Hypoproteinemia (HP:0003075)2.06554924
121Tubulointerstitial fibrosis (HP:0005576)2.05064116
122Premature skin wrinkling (HP:0100678)2.04119314
123Cortical dysplasia (HP:0002539)2.03883706
124Rickets (HP:0002748)2.03041609
125Abnormal enzyme/coenzyme activity (HP:0012379)2.02229535
126Poikilocytosis (HP:0004447)2.02106582
127Abnormality of alkaline phosphatase activity (HP:0004379)2.02005245
128Abnormality of magnesium homeostasis (HP:0004921)2.01687234
129Abnormal glycosylation (HP:0012345)2.01305739
130Abnormal isoelectric focusing of serum transferrin (HP:0003160)2.01305739
131Abnormal protein N-linked glycosylation (HP:0012347)2.01305739
132Abnormal protein glycosylation (HP:0012346)2.01305739
133Irritability (HP:0000737)2.00344002
134Abnormality of serum amino acid levels (HP:0003112)2.00093743
135Renal salt wasting (HP:0000127)1.99936768
136Hypophosphatemic rickets (HP:0004912)1.99553853
137Alkalosis (HP:0001948)1.98548800
138Hyperbilirubinemia (HP:0002904)1.98421533
139Progressive macrocephaly (HP:0004481)1.96146659
140Abnormality of carpal bone ossification (HP:0006257)1.89504974
141Renal tubular acidosis (HP:0001947)1.88029041
142Hypoalphalipoproteinemia (HP:0003233)1.87934633
143Abnormality of the costochondral junction (HP:0000919)1.86932937
144Amyloidosis (HP:0011034)1.85513998
145Villous atrophy (HP:0011473)1.85309697
146Abnormality of small intestinal villus morphology (HP:0011472)1.85309697
147Gingival bleeding (HP:0000225)1.81653814
148Elevated alkaline phosphatase (HP:0003155)1.80268701

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BCKDK9.07488944
2ACVR1B7.02681750
3MAP2K24.77685092
4ERN14.49633642
5RIPK14.01192398
6EPHA23.87163334
7FGFR43.68131721
8NME13.37207679
9FRK3.11607866
10WNK43.10334624
11EIF2AK32.61633062
12TESK22.27516829
13STK392.23118451
14MAPK152.07304857
15MST1R2.00725281
16MAP3K101.98947355
17NME21.97872336
18PKN21.93086401
19LMTK21.91499044
20OXSR11.91431593
21MST41.91000572
22FGFR31.89590472
23MAP2K11.63215702
24INSRR1.59435450
25TYK21.53571185
26TAOK31.50032657
27EPHA41.48091988
28SCYL21.44457499
29GRK61.36979011
30TRIB31.36925316
31EPHA31.35823714
32MAP2K61.33824624
33WNK31.33655318
34PAK21.29805912
35IRAK31.26951741
36PTK61.22031248
37AKT31.14704347
38MAP4K11.13604060
39PIK3CG1.13150686
40MAP3K21.10097302
41RPS6KB21.09187432
42MAP3K121.08746149
43MAPKAPK31.03365616
44ZAP701.01007635
45MET0.97961967
46PIK3CA0.95641501
47STK160.84087901
48PRKG20.83082964
49DYRK1A0.80967089
50TNIK0.76441897
51CDC42BPA0.76301182
52PRKCI0.73908552
53MAP3K110.70320325
54STK240.70185438
55EPHB10.69443660
56TBK10.68444263
57MAP3K80.66315587
58LRRK20.64151670
59ICK0.63234597
60PDPK10.62965835
61RET0.59626087
62DAPK20.58357288
63PRKCZ0.55661177
64PDK20.55393896
65MAPK110.55306930
66GRK10.54992066
67NLK0.54537197
68PRPF4B0.54321574
69TAOK10.53714176
70CSF1R0.53202156
71SRC0.53194782
72PDGFRA0.52849590
73FLT30.52159111
74BRAF0.49742041
75RIPK40.49114403
76KSR20.47182123
77MATK0.46910091
78TESK10.46849718
79DYRK1B0.45158422
80PTK20.44809906
81PDK10.43231705
82MAP3K10.41672302
83IRAK20.40319998
84MAPKAPK50.38984664
85TYRO30.38320063
86CASK0.38247826
87MAP3K30.37306131
88ITK0.36480549
89CDK190.35689281
90GSK3A0.34851231
91IGF1R0.34778665
92MUSK0.34730823
93PRKACB0.33945673
94CDK60.33689603
95MYLK0.33178877
96KDR0.33068696
97CAMK2B0.32951699
98PDGFRB0.32672294
99ABL20.31212278
100FYN0.31203364
101MAP3K70.30996228
102EIF2AK10.30249345
103MAPK120.29801085
104TGFBR20.29567327
105CSNK1A10.29374635
106IKBKE0.29174091
107JAK20.28927185
108CAMK2G0.28762958
109JAK10.28065373
110PIM10.27200916
111PRKCA0.26953021
112PRKCD0.26859088
113PRKAA20.26615756
114ERBB20.26524341
115DDR20.24490873
116PRKCQ0.24400762
117PRKACG0.24101872
118PRKAA10.24019328
119CAMK2D0.23907050
120IRAK10.23880363
121FGFR20.23792118
122FGR0.23790619
123CSK0.23653702
124CSNK1G30.23164755
125PINK10.22576648
126PRKACA0.22315359
127EPHB20.22000719
128CAMKK10.21829152
129YES10.21400531
130PAK30.20955602
131MAPK30.20777011
132RPS6KB10.20378133
133SIK10.20034322
134BMX0.19525160
135LYN0.18709990
136DAPK30.18267748
137TLK10.17818194
138SYK0.17640257
139NTRK10.17544601
140DYRK20.17535009
141CSNK1G10.17222055
142PDK40.17148300
143PDK30.17148300
144ADRBK20.16885262
145FER0.16166984
146STK100.15668722
147EEF2K0.13629663
148CSNK1E0.13524958
149VRK10.13334769

Predicted pathways (KEGG)

RankGene SetZ-score
1Fat digestion and absorption_Homo sapiens_hsa049755.32600612
2Pancreatic secretion_Homo sapiens_hsa049724.86303847
3Protein digestion and absorption_Homo sapiens_hsa049743.80810910
4Cyanoamino acid metabolism_Homo sapiens_hsa004602.90136531
5Folate biosynthesis_Homo sapiens_hsa007902.76043998
6Glycine, serine and threonine metabolism_Homo sapiens_hsa002602.67836425
7Vitamin digestion and absorption_Homo sapiens_hsa049772.62600522
8Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.50100914
9Maturity onset diabetes of the young_Homo sapiens_hsa049502.45052130
10Glycerolipid metabolism_Homo sapiens_hsa005612.32328293
11Ascorbate and aldarate metabolism_Homo sapiens_hsa000532.15024703
12Propanoate metabolism_Homo sapiens_hsa006402.08607917
13Steroid biosynthesis_Homo sapiens_hsa001001.93073109
14Sulfur metabolism_Homo sapiens_hsa009201.87095697
15Renin-angiotensin system_Homo sapiens_hsa046141.82821293
16Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.81831833
17Protein export_Homo sapiens_hsa030601.76809616
18Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.74583933
19Arginine and proline metabolism_Homo sapiens_hsa003301.69390143
20Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.59507701
212-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.58024370
22Fatty acid degradation_Homo sapiens_hsa000711.51247771
23Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.49065470
24Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.47343928
25Tryptophan metabolism_Homo sapiens_hsa003801.44788484
26Butanoate metabolism_Homo sapiens_hsa006501.41853768
27Starch and sucrose metabolism_Homo sapiens_hsa005001.37421024
28Arginine biosynthesis_Homo sapiens_hsa002201.35693117
29Histidine metabolism_Homo sapiens_hsa003401.31858934
30Nitrogen metabolism_Homo sapiens_hsa009101.31479491
31beta-Alanine metabolism_Homo sapiens_hsa004101.29476849
32Primary bile acid biosynthesis_Homo sapiens_hsa001201.29284714
33Pyruvate metabolism_Homo sapiens_hsa006201.28328869
34Oxidative phosphorylation_Homo sapiens_hsa001901.26801227
35Pentose and glucuronate interconversions_Homo sapiens_hsa000401.21598507
36alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.21229913
37Glutathione metabolism_Homo sapiens_hsa004801.16724912
38Parkinsons disease_Homo sapiens_hsa050121.16356734
39Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.14668741
40Fructose and mannose metabolism_Homo sapiens_hsa000511.10486333
41Staphylococcus aureus infection_Homo sapiens_hsa051501.09677689
42Biosynthesis of amino acids_Homo sapiens_hsa012301.08285236
43Linoleic acid metabolism_Homo sapiens_hsa005911.07930498
44Mineral absorption_Homo sapiens_hsa049781.06862032
45Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.04939858
46Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.02946539
47Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.98391432
48Bile secretion_Homo sapiens_hsa049760.97166301
49Galactose metabolism_Homo sapiens_hsa000520.96378873
50Peroxisome_Homo sapiens_hsa041460.95381243
51Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.95041978
52Carbon metabolism_Homo sapiens_hsa012000.90834104
53Selenocompound metabolism_Homo sapiens_hsa004500.90121438
54Alzheimers disease_Homo sapiens_hsa050100.89567930
55Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.89416997
56Fatty acid metabolism_Homo sapiens_hsa012120.89308507
57Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.87533399
58Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.85183235
59Cysteine and methionine metabolism_Homo sapiens_hsa002700.84251966
60PPAR signaling pathway_Homo sapiens_hsa033200.83370250
61Fatty acid elongation_Homo sapiens_hsa000620.81648081
62Chemical carcinogenesis_Homo sapiens_hsa052040.80884739
63Carbohydrate digestion and absorption_Homo sapiens_hsa049730.80335886
64Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.78331457
65Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.78326644
66Other glycan degradation_Homo sapiens_hsa005110.72002826
67Sulfur relay system_Homo sapiens_hsa041220.65219280
68Metabolic pathways_Homo sapiens_hsa011000.64648978
69Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.64221445
70Arachidonic acid metabolism_Homo sapiens_hsa005900.61191709
71Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.59492168
72Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.59436536
73Huntingtons disease_Homo sapiens_hsa050160.51553531
74Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.50526708
75Asthma_Homo sapiens_hsa053100.49118495
76Ether lipid metabolism_Homo sapiens_hsa005650.46229495
77Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.45615979
78Pentose phosphate pathway_Homo sapiens_hsa000300.44426631
79Drug metabolism - other enzymes_Homo sapiens_hsa009830.44066051
80Intestinal immune network for IgA production_Homo sapiens_hsa046720.41580102
81Fatty acid biosynthesis_Homo sapiens_hsa000610.40941593
82Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.40363487
83N-Glycan biosynthesis_Homo sapiens_hsa005100.39828340
84Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.37635954
85Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.37160168
86Insulin resistance_Homo sapiens_hsa049310.36544555
87One carbon pool by folate_Homo sapiens_hsa006700.35598179
88Phenylalanine metabolism_Homo sapiens_hsa003600.35504669
89Vibrio cholerae infection_Homo sapiens_hsa051100.34935097
90Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.34651102
91Vitamin B6 metabolism_Homo sapiens_hsa007500.31650537
92Ribosome_Homo sapiens_hsa030100.29480688
93Complement and coagulation cascades_Homo sapiens_hsa046100.29397437
94Retinol metabolism_Homo sapiens_hsa008300.26310406
95Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.25720614
96Adipocytokine signaling pathway_Homo sapiens_hsa049200.24780945
97Glycerophospholipid metabolism_Homo sapiens_hsa005640.23596973
98Pertussis_Homo sapiens_hsa051330.23378476
99Prion diseases_Homo sapiens_hsa050200.23266178
100Allograft rejection_Homo sapiens_hsa053300.22719884
101Steroid hormone biosynthesis_Homo sapiens_hsa001400.22402857
102Glucagon signaling pathway_Homo sapiens_hsa049220.20602912
103Autoimmune thyroid disease_Homo sapiens_hsa053200.19774085
104ABC transporters_Homo sapiens_hsa020100.19191997
105Lysine degradation_Homo sapiens_hsa003100.18753211
106Influenza A_Homo sapiens_hsa051640.18593657
107Caffeine metabolism_Homo sapiens_hsa002320.16764338
108Graft-versus-host disease_Homo sapiens_hsa053320.16476970
109Sphingolipid metabolism_Homo sapiens_hsa006000.12312587
110Thyroid hormone synthesis_Homo sapiens_hsa049180.11346390
111Insulin secretion_Homo sapiens_hsa049110.10838361
112Renin secretion_Homo sapiens_hsa049240.09669486
113Type I diabetes mellitus_Homo sapiens_hsa049400.08269168
114Tyrosine metabolism_Homo sapiens_hsa003500.07817507
115Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.07520127
116Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.07419160
117African trypanosomiasis_Homo sapiens_hsa051430.04096579
118Glycosaminoglycan degradation_Homo sapiens_hsa005310.01659745
119Hepatitis C_Homo sapiens_hsa051600.00503516
120AMPK signaling pathway_Homo sapiens_hsa04152-0.0232875
121Cocaine addiction_Homo sapiens_hsa05030-0.0167981

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