SLC39A6

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: Zinc is an essential cofactor for hundreds of enzymes. It is involved in protein, nucleic acid, carbohydrate, and lipid metabolism, as well as in the control of gene transcription, growth, development, and differentiation. SLC39A6 belongs to a subfamily of proteins that show structural characteristics of zinc transporters (Taylor and Nicholson, 2003 [PubMed 12659941]). NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1positive regulation of keratinocyte differentiation (GO:0045618)5.56367013
2intestinal epithelial cell development (GO:0060576)4.96282367
3dichotomous subdivision of an epithelial terminal unit (GO:0060600)4.92959007
4ear development (GO:0043583)4.64815983
5regulation of branching involved in prostate gland morphogenesis (GO:0060687)4.63461500
6vagina development (GO:0060068)4.36614434
7regulation of centriole replication (GO:0046599)4.21908863
8desmosome organization (GO:0002934)4.15399042
9positive regulation of epidermal cell differentiation (GO:0045606)4.15025863
10hemidesmosome assembly (GO:0031581)4.14141023
11cardiac right ventricle morphogenesis (GO:0003215)4.03050961
12prostate epithelial cord arborization involved in prostate glandular acinus morphogenesis (GO:0060523.99927391
13branching involved in mammary gland duct morphogenesis (GO:0060444)3.56580865
14female genitalia development (GO:0030540)3.55620357
15retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)3.51446268
16epithelial cell maturation (GO:0002070)3.43395318
17regulation of Arp2/3 complex-mediated actin nucleation (GO:0034315)3.41690796
18apical protein localization (GO:0045176)3.41684301
19regulation of water loss via skin (GO:0033561)3.35104686
20uterus development (GO:0060065)3.25165790
21ER overload response (GO:0006983)3.24379415
22hepatocyte apoptotic process (GO:0097284)3.22937834
23body morphogenesis (GO:0010171)3.22791623
24axonal fasciculation (GO:0007413)3.16346807
25mammary gland epithelial cell proliferation (GO:0033598)3.15037911
26mammary gland alveolus development (GO:0060749)3.11432335
27COPII vesicle coating (GO:0048208)3.11412012
28asymmetric protein localization (GO:0008105)3.11056580
29regulation of keratinocyte differentiation (GO:0045616)3.10727320
30neuron cell-cell adhesion (GO:0007158)3.10270678
31axon extension involved in axon guidance (GO:0048846)3.09976419
32neuron projection extension involved in neuron projection guidance (GO:1902284)3.09976419
33gonadal mesoderm development (GO:0007506)3.09475825
34layer formation in cerebral cortex (GO:0021819)3.06343536
35maternal placenta development (GO:0001893)3.04875346
36chondrocyte proliferation (GO:0035988)3.04706552
37regulation of fatty acid beta-oxidation (GO:0031998)3.04159954
38insulin-like growth factor receptor signaling pathway (GO:0048009)3.03373534
39branching involved in prostate gland morphogenesis (GO:0060442)3.03285713
40positive regulation of calcium ion-dependent exocytosis (GO:0045956)2.96085887
41norepinephrine metabolic process (GO:0042415)2.93138575
42cell migration in hindbrain (GO:0021535)2.89845616
43ectodermal placode formation (GO:0060788)2.89406337
44negative regulation of organelle assembly (GO:1902116)2.88487027
45axon extension (GO:0048675)2.84819204
46polarized epithelial cell differentiation (GO:0030859)2.82490610
47negative regulation of axon guidance (GO:1902668)2.82097341
48striated muscle atrophy (GO:0014891)2.79720015
49neuron recognition (GO:0008038)2.78901846
50dendrite morphogenesis (GO:0048813)2.77820429
51adenylate cyclase-activating dopamine receptor signaling pathway (GO:0007191)2.75706352
52response to stimulus involved in regulation of muscle adaptation (GO:0014874)2.75599638
53protein retention in ER lumen (GO:0006621)2.72065213
54semaphorin-plexin signaling pathway (GO:0071526)2.71671997
55epithelial cell differentiation involved in prostate gland development (GO:0060742)2.69079512
56piRNA metabolic process (GO:0034587)2.67736127
57establishment of planar polarity (GO:0001736)2.67027893
58establishment of tissue polarity (GO:0007164)2.67027893
59regulation of short-term neuronal synaptic plasticity (GO:0048172)2.66683130
60maintenance of protein localization in endoplasmic reticulum (GO:0035437)2.66456740
61biotin metabolic process (GO:0006768)2.65633949
62TOR signaling (GO:0031929)2.65491496
63negative regulation of microtubule polymerization (GO:0031115)2.64457772
64positive regulation of epidermis development (GO:0045684)2.64345280
65spliceosomal tri-snRNP complex assembly (GO:0000244)2.62463459
66central nervous system projection neuron axonogenesis (GO:0021952)2.61294237
67negative regulation of axon extension involved in axon guidance (GO:0048843)2.61262991
68proline biosynthetic process (GO:0006561)2.61146994
69embryonic body morphogenesis (GO:0010172)2.59872777
70regulation of mammary gland epithelial cell proliferation (GO:0033599)2.59838876
71positive regulation of axon extension (GO:0045773)2.57280598
72muscle atrophy (GO:0014889)2.56947279
73embryonic camera-type eye morphogenesis (GO:0048596)2.56233074
74establishment of skin barrier (GO:0061436)2.56033554
75regulation of glucose import in response to insulin stimulus (GO:2001273)2.53936022
76sequestering of extracellular ligand from receptor (GO:0035581)2.53059765
77regulation of cell proliferation involved in kidney development (GO:1901722)2.53041863
78establishment of nucleus localization (GO:0040023)2.52905534
79positive regulation of translational initiation (GO:0045948)2.52660764
80prostate gland epithelium morphogenesis (GO:0060740)2.52392770
81adherens junction assembly (GO:0034333)2.49498911
82negative regulation of keratinocyte proliferation (GO:0010839)2.49382413
83exocrine pancreas development (GO:0031017)2.49258208
84vesicle coating (GO:0006901)2.49084276
85regulation of axon guidance (GO:1902667)2.49074629
86dendritic spine morphogenesis (GO:0060997)2.48475803
87peptidyl-tyrosine autophosphorylation (GO:0038083)2.47991794
88regulation of attachment of spindle microtubules to kinetochore (GO:0051988)2.47172851
89ectoderm development (GO:0007398)2.46979302
90positive regulation of protein depolymerization (GO:1901881)2.46712078
91keratinocyte development (GO:0003334)2.46164752
92positive regulation of nitric-oxide synthase activity (GO:0051000)2.45607992
93neuron projection extension (GO:1990138)2.44791246
94positive regulation of G2/M transition of mitotic cell cycle (GO:0010971)2.44608734
95positive regulation of cell cycle G2/M phase transition (GO:1902751)2.44608734
96regulation of centrosome duplication (GO:0010824)2.44401366
97embryonic eye morphogenesis (GO:0048048)2.43801031
98amyloid precursor protein catabolic process (GO:0042987)2.43330400
99skeletal muscle adaptation (GO:0043501)2.42764087
100intracellular estrogen receptor signaling pathway (GO:0030520)2.41223449
101cardiac ventricle morphogenesis (GO:0003208)2.41069950
102melanin metabolic process (GO:0006582)2.40475799
103exploration behavior (GO:0035640)2.40360719
104post-embryonic morphogenesis (GO:0009886)2.40283279
105prostate gland growth (GO:0060736)2.40244871
106negative regulation of cell size (GO:0045792)2.39062529
107negative regulation of fibroblast growth factor receptor signaling pathway (GO:0040037)2.38274105
108limb bud formation (GO:0060174)2.38247457
109nuclear pore complex assembly (GO:0051292)2.36729978
110clathrin coat assembly (GO:0048268)2.36073654
111cellular response to prostaglandin stimulus (GO:0071379)2.35622644
112cell-substrate junction assembly (GO:0007044)2.34423999
113surfactant homeostasis (GO:0043129)2.33570478
114L-alpha-amino acid transmembrane transport (GO:1902475)2.32928375
115positive regulation of skeletal muscle tissue development (GO:0048643)2.32494703
116regulation of axon extension involved in axon guidance (GO:0048841)2.32170990
117paraxial mesoderm development (GO:0048339)2.31698306
118synaptic vesicle exocytosis (GO:0016079)2.31649188
119collagen fibril organization (GO:0030199)2.31458606
120protein complex localization (GO:0031503)2.30924057
121protein localization to synapse (GO:0035418)2.29842095
122regulation of axon extension (GO:0030516)2.29192432
123epithelial tube branching involved in lung morphogenesis (GO:0060441)2.27321965
124innervation (GO:0060384)2.27264116
125nuclear-transcribed mRNA poly(A) tail shortening (GO:0000289)2.26959473
126regulation of protein localization to cell surface (GO:2000008)2.26020129
127pyrimidine nucleobase catabolic process (GO:0006208)2.24174727
128dermatan sulfate biosynthetic process (GO:0030208)2.24034427
129negative chemotaxis (GO:0050919)2.23114392
130peptidyl-arginine N-methylation (GO:0035246)2.22391349
131peptidyl-arginine methylation (GO:0018216)2.22391349
132peptidyl-arginine omega-N-methylation (GO:0035247)2.16603127
133ganglion development (GO:0061548)2.15036710
134central nervous system neuron axonogenesis (GO:0021955)2.14784547
135positive regulation of fibroblast migration (GO:0010763)2.14742350
136positive regulation of synapse assembly (GO:0051965)2.14491974
137regulation of NFAT protein import into nucleus (GO:0051532)2.13315614
138metanephric mesenchyme development (GO:0072075)2.12219008
139regulation of extent of cell growth (GO:0061387)2.11853913
140kidney mesenchyme development (GO:0072074)2.08742309
141dermatan sulfate metabolic process (GO:0030205)2.08368259
142proline transport (GO:0015824)2.08270201
143negative regulation of fatty acid transport (GO:2000192)2.07783055
144retinal ganglion cell axon guidance (GO:0031290)2.07282374
145developmental cell growth (GO:0048588)2.07009309
146locomotory exploration behavior (GO:0035641)2.06317022
147negative regulation of axon extension (GO:0030517)2.06246053
148sympathetic nervous system development (GO:0048485)2.05989725
149regulation of early endosome to late endosome transport (GO:2000641)2.05950717
150vocalization behavior (GO:0071625)2.05675512
151positive regulation of actin filament depolymerization (GO:0030836)2.05653754
152positive regulation of meiosis (GO:0045836)2.05436388
153regulation of inhibitory postsynaptic membrane potential (GO:0060080)2.04887507
154neuron migration (GO:0001764)2.04599648
155male meiosis (GO:0007140)2.03308753
156regulation of synaptic vesicle exocytosis (GO:2000300)2.03246543
157chondrocyte development (GO:0002063)2.02870792
158positive regulation of protein complex disassembly (GO:0043243)2.02306521
159response to pheromone (GO:0019236)2.02205968
160regulation of respiratory gaseous exchange by neurological system process (GO:0002087)2.01903240
161COPI coating of Golgi vesicle (GO:0048205)2.01864837
162Golgi transport vesicle coating (GO:0048200)2.01864837
163SMAD protein complex assembly (GO:0007183)2.01133560
164cytoskeleton-dependent cytokinesis (GO:0061640)2.00669537
165synaptic vesicle maturation (GO:0016188)2.00093068
166negative regulation of axonogenesis (GO:0050771)1.99405747
167positive regulation of male gonad development (GO:2000020)1.99062640
168regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway 1.98669139
169positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling1.98669139
170positive regulation of axonogenesis (GO:0050772)1.98561388
171mitotic sister chromatid cohesion (GO:0007064)1.96113659
172dopaminergic neuron differentiation (GO:0071542)1.96103488
173positive regulation of meiotic cell cycle (GO:0051446)1.95722088
174mitotic cytokinesis (GO:0000281)1.95149331
175regulation of meiosis (GO:0040020)1.94483375
176proximal/distal pattern formation (GO:0009954)1.94213645
177craniofacial suture morphogenesis (GO:0097094)1.92140863
178protein targeting to plasma membrane (GO:0072661)1.91992488
179glutamate secretion (GO:0014047)1.91937666
180heparan sulfate proteoglycan metabolic process (GO:0030201)1.91038975
181cerebellum development (GO:0021549)1.89910853
182cerebral cortex radially oriented cell migration (GO:0021799)1.89665098
183hippocampus development (GO:0021766)1.88916298
184cerebellar Purkinje cell layer development (GO:0021680)1.88718516
185regulation of cAMP-dependent protein kinase activity (GO:2000479)1.87545606
186ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway (GO:0043161.86984457
187hippo signaling (GO:0035329)1.86776561
188dopamine biosynthetic process (GO:0042416)1.85975983
189postsynaptic membrane organization (GO:0001941)1.85560336
190negative regulation of catenin import into nucleus (GO:0035414)1.85317228

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TP63_17297297_ChIP-ChIP_HaCaT_Human5.44898886
2ESR1_20079471_ChIP-ChIP_T-47D_Human5.25354662
3ESR1_21235772_ChIP-Seq_MCF-7_Human5.07292891
4EZH2_22144423_ChIP-Seq_EOC_Human4.47772117
5ESR2_21235772_ChIP-Seq_MCF-7_Human4.06127043
6ESR1_15608294_ChIP-ChIP_MCF-7_Human3.98001680
7HIF1A_21447827_ChIP-Seq_MCF-7_Human3.43365684
8ZNF263_19887448_ChIP-Seq_K562_Human2.75480892
9AHR_22903824_ChIP-Seq_MCF-7_Human2.65422390
10STAT6_21828071_ChIP-Seq_BEAS2B_Human2.56389705
11E2F7_22180533_ChIP-Seq_HELA_Human2.52161582
12TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse2.46328984
13RBPJ_22232070_ChIP-Seq_NCS_Mouse2.46198062
14TFAP2C_20629094_ChIP-Seq_MCF-7_Human2.44687457
15JARID2_20064375_ChIP-Seq_MESCs_Mouse2.40420913
16FOXM1_23109430_ChIP-Seq_U2OS_Human2.40033863
17EZH2_27304074_Chip-Seq_ESCs_Mouse2.39726060
18ZFP322A_24550733_ChIP-Seq_MESCs_Mouse2.25253913
19RNF2_18974828_ChIP-Seq_MESCs_Mouse2.17698168
20EZH2_18974828_ChIP-Seq_MESCs_Mouse2.17698168
21GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.17338005
22RUNX1_27514584_Chip-Seq_MCF-7_Human2.17283640
23AR_21909140_ChIP-Seq_LNCAP_Human2.16184825
24GATA3_24758297_ChIP-Seq_MCF-7_Human2.16170682
25SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.15445120
26ZNF274_21170338_ChIP-Seq_K562_Hela2.14738402
27GBX2_23144817_ChIP-Seq_PC3_Human2.13815606
28PADI4_21655091_ChIP-ChIP_MCF-7_Human2.11008302
29SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.10504011
30RNF2_27304074_Chip-Seq_ESCs_Mouse2.10061373
31JARID2_20075857_ChIP-Seq_MESCs_Mouse2.07120895
32EED_16625203_ChIP-ChIP_MESCs_Mouse2.06718976
33SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.04603884
34NR4A2_19515692_ChIP-ChIP_MN9D_Mouse2.02514182
35SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.00938996
36SALL1_21062744_ChIP-ChIP_HESCs_Human1.99216264
37ARNT_22903824_ChIP-Seq_MCF-7_Human1.98808800
38TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.98117845
39AR_21572438_ChIP-Seq_LNCaP_Human1.96272032
40SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.93543453
41STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.93381327
42PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.90765722
43RNF2_27304074_Chip-Seq_NSC_Mouse1.89087367
44TRIM28_21343339_ChIP-Seq_HEK293_Human1.88721858
45KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.88348453
46ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.84724682
47CBX2_27304074_Chip-Seq_ESCs_Mouse1.84662649
48ZFX_18555785_ChIP-Seq_MESCs_Mouse1.83445205
49ER_23166858_ChIP-Seq_MCF-7_Human1.82070321
50CTBP2_25329375_ChIP-Seq_LNCAP_Human1.81098406
51MTF2_20144788_ChIP-Seq_MESCs_Mouse1.80083576
52CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.78060425
53WT1_19549856_ChIP-ChIP_CCG9911_Human1.77262495
54CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.75268306
55RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.73927681
56DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.71986705
57PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.69064221
58BMI1_23680149_ChIP-Seq_NPCS_Mouse1.67968129
59* FOXM1_26456572_ChIP-Seq_MCF-7_Human1.67575971
60SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.67165269
61EZH2_27294783_Chip-Seq_ESCs_Mouse1.65763043
62MYC_18555785_ChIP-Seq_MESCs_Mouse1.65408687
63HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.63616284
64WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.63379533
65RACK7_27058665_Chip-Seq_MCF-7_Human1.63189904
66IKZF1_21737484_ChIP-ChIP_HCT116_Human1.61597799
67* CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.58957752
68SUZ12_27294783_Chip-Seq_ESCs_Mouse1.57367976
69PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.55608586
70FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.55435131
71E2F1_21310950_ChIP-Seq_MCF-7_Human1.51770913
72* NELFA_20434984_ChIP-Seq_ESCs_Mouse1.50399117
73HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.48976895
74* CLOCK_20551151_ChIP-Seq_293T_Human1.47223712
75PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.46983990
76IGF1R_20145208_ChIP-Seq_DFB_Human1.44581504
77SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.44538068
78DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.43476342
79NR3C1_23031785_ChIP-Seq_PC12_Mouse1.41001218
80* MYCN_18555785_ChIP-Seq_MESCs_Mouse1.38939326
81DCP1A_22483619_ChIP-Seq_HELA_Human1.38576729
82KDM5A_27292631_Chip-Seq_BREAST_Human1.36125515
83CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse1.35707444
84OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.35262870
85EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.34445533
86CHD1_26751641_Chip-Seq_LNCaP_Human1.34010990
87TDRD3_21172665_ChIP-Seq_MCF-7_Human1.33470524
88ELF5_23300383_ChIP-Seq_T47D_Human1.33383089
89RING1B_27294783_Chip-Seq_NPCs_Mouse1.31573326
90* CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.29544347
91SMAD4_21799915_ChIP-Seq_A2780_Human1.26245520
92NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.25048683
93POU3F2_20337985_ChIP-ChIP_501MEL_Human1.23861239
94SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.23247185
95EWS_26573619_Chip-Seq_HEK293_Human1.23139911
96REST_21632747_ChIP-Seq_MESCs_Mouse1.22379123
97EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.21378423
98ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.19813683
99CDX2_19796622_ChIP-Seq_MESCs_Mouse1.19687559
100YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.18440745
101TOP2B_26459242_ChIP-Seq_MCF-7_Human1.18376296
102CTBP1_25329375_ChIP-Seq_LNCAP_Human1.18313659
103P300_19829295_ChIP-Seq_ESCs_Human1.18302071
104TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.18186703
105ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.17729576
106* ZNF217_24962896_ChIP-Seq_MCF-7_Human1.17163342
107ZFP281_18757296_ChIP-ChIP_E14_Mouse1.16753427
108* KLF4_18555785_ChIP-Seq_MESCs_Mouse1.15677137
109MYC_19030024_ChIP-ChIP_MESCs_Mouse1.15242305
110SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.14731861
111YAP1_20516196_ChIP-Seq_MESCs_Mouse1.14728534
112RING1B_27294783_Chip-Seq_ESCs_Mouse1.14467753
113TP53_18474530_ChIP-ChIP_U2OS_Human1.14248019
114SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.14218193
115ZFP57_27257070_Chip-Seq_ESCs_Mouse1.13655579
116FUS_26573619_Chip-Seq_HEK293_Human1.13499305
117MYC_19079543_ChIP-ChIP_MESCs_Mouse1.13300436
118TP53_20018659_ChIP-ChIP_R1E_Mouse1.13091595
119DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.12904543
120KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.12334688
121SMAD_19615063_ChIP-ChIP_OVARY_Human1.11763791
122SOX2_21211035_ChIP-Seq_LN229_Gbm1.11745432
123SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.08203519
124TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.08192504
125SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.06940406
126SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.06940406
127SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.05766822
128* JUN_21703547_ChIP-Seq_K562_Human1.05486700
129* AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.05344774
130DROSHA_22980978_ChIP-Seq_HELA_Human1.05339452
131XRN2_22483619_ChIP-Seq_HELA_Human1.05037349
132NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.04598480
133* OLIG2_26023283_ChIP-Seq_AINV15_Mouse1.04345182
134REST_18959480_ChIP-ChIP_MESCs_Mouse1.03348897
135EGR1_19374776_ChIP-ChIP_THP-1_Human1.03016243
136TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.02807640
137CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.02138011
138TP63_19390658_ChIP-ChIP_HaCaT_Human1.01112876
139AR_25329375_ChIP-Seq_VCAP_Human1.00507593
140STAT3_23295773_ChIP-Seq_U87_Human1.00116756
141TAF15_26573619_Chip-Seq_HEK293_Human1.00097136
142EOMES_20176728_ChIP-ChIP_TSCs_Mouse0.99951526
143BCAT_22108803_ChIP-Seq_LS180_Human0.98201611
144BRD4_25478319_ChIP-Seq_HGPS_Human0.98122163
145SMAD3_21741376_ChIP-Seq_ESCs_Human0.97969257
146ELK4_26923725_Chip-Seq_MESODERM_Mouse0.97895135
147SMAD3_21741376_ChIP-Seq_EPCs_Human0.97746328
148PIAS1_25552417_ChIP-Seq_VCAP_Human0.95836818
149HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse0.95407897
150P53_22127205_ChIP-Seq_FIBROBLAST_Human0.94828346
151POU5F1_18555785_ChIP-Seq_MESCs_Mouse0.93792323
152CJUN_26792858_Chip-Seq_BT549_Human0.93431911
153PRDM14_20953172_ChIP-Seq_ESCs_Human0.93242854
154KDM2B_26808549_Chip-Seq_K562_Human0.93137948
155POU5F1_16153702_ChIP-ChIP_HESCs_Human0.92978948
156FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human0.92815441
157* GABP_19822575_ChIP-Seq_HepG2_Human0.92320088
158EP300_21415370_ChIP-Seq_HL-1_Mouse0.92235174
159MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse0.92121608
160TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse0.92050115
161NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse0.91620630
162RARB_27405468_Chip-Seq_BRAIN_Mouse0.91536090
163TRIM28_19339689_ChIP-ChIP_MESCs_Mouse0.91279030
164ZFP281_18358816_ChIP-ChIP_MESCs_Mouse0.91207117
165PKCTHETA_26484144_Chip-Seq_BREAST_Human0.91143971
166TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.91093829
167GATA6_25053715_ChIP-Seq_YYC3_Human0.87934385
168CCND1_20090754_ChIP-ChIP_RETINA_Mouse0.84179525
169ERG_21242973_ChIP-ChIP_JURKAT_Human0.81277862
170SOX17_20123909_ChIP-Seq_XEN_Mouse0.80759867
171E2F4_17652178_ChIP-ChIP_JURKAT_Human0.80261559
172FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human0.79644217
173SOX9_24532713_ChIP-Seq_HFSC_Mouse0.79462957
174SOX2_27498859_Chip-Seq_STOMACH_Mouse0.79239431
175SREBP1_19666523_ChIP-Seq_LIVER_Mouse0.77415034
176* MYC_18358816_ChIP-ChIP_MESCs_Mouse0.76616006
177TFEB_21752829_ChIP-Seq_HELA_Human0.75947867
178E2F1_18555785_ChIP-Seq_MESCs_Mouse0.75483805
179POU5F1_18700969_ChIP-ChIP_MESCs_Mouse0.75195122
180ATF3_27146783_Chip-Seq_COLON_Human0.74584307

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0000579_abnormal_nail_morphology3.12173286
2MP0010234_abnormal_vibrissa_follicle3.09587183
3MP0000569_abnormal_digit_pigmentation3.08272068
4MP0005408_hypopigmentation2.85668259
5MP0003941_abnormal_skin_development2.83704567
6MP0004264_abnormal_extraembryonic_tissu2.83472339
7MP0004381_abnormal_hair_follicle2.60052331
8MP0003122_maternal_imprinting2.58265716
9MP0008438_abnormal_cutaneous_collagen2.57645112
10MP0004859_abnormal_synaptic_plasticity2.57047847
11MP0000383_abnormal_hair_follicle2.54301841
12MP0002796_impaired_skin_barrier2.48824044
13MP0010678_abnormal_skin_adnexa2.44318103
14MP0005503_abnormal_tendon_morphology2.35953154
15MP0003123_paternal_imprinting2.24599298
16MP0000427_abnormal_hair_cycle2.17299137
17MP0006276_abnormal_autonomic_nervous2.15053589
18MP0002098_abnormal_vibrissa_morphology1.97059086
19MP0000462_abnormal_digestive_system1.95452158
20MP0003121_genomic_imprinting1.95345022
21MP0000778_abnormal_nervous_system1.92250250
22MP0005623_abnormal_meninges_morphology1.90829829
23MP0005275_abnormal_skin_tensile1.85859990
24MP0003787_abnormal_imprinting1.85429950
25MP0004782_abnormal_surfactant_physiolog1.75505418
26MP0002184_abnormal_innervation1.74313485
27MP0000377_abnormal_hair_follicle1.71316206
28MP0004270_analgesia1.69202877
29MP0005248_abnormal_Harderian_gland1.67996920
30MP0003942_abnormal_urinary_system1.66386655
31MP0001299_abnormal_eye_distance/1.66028668
32MP0008877_abnormal_DNA_methylation1.62949912
33MP0003385_abnormal_body_wall1.59064661
34MP0005501_abnormal_skin_physiology1.58667846
35MP0000467_abnormal_esophagus_morphology1.58289809
36MP0005645_abnormal_hypothalamus_physiol1.56246276
37MP0003635_abnormal_synaptic_transmissio1.55511181
38MP0002735_abnormal_chemical_nociception1.53849231
39MP0002060_abnormal_skin_morphology1.53726398
40MP0000627_abnormal_mammary_gland1.53233335
41MP0000372_irregular_coat_pigmentation1.49194612
42MP0002009_preneoplasia1.48965460
43MP0002734_abnormal_mechanical_nocicepti1.47854174
44MP0009250_abnormal_appendicular_skeleto1.46158696
45MP0002751_abnormal_autonomic_nervous1.46154311
46MP0000537_abnormal_urethra_morphology1.45045569
47MP0002102_abnormal_ear_morphology1.43593317
48MP0001849_ear_inflammation1.39062655
49MP0009672_abnormal_birth_weight1.38955773
50MP0000538_abnormal_urinary_bladder1.36869952
51MP0002063_abnormal_learning/memory/cond1.35013296
52MP0005075_abnormal_melanosome_morpholog1.34362649
53MP0003693_abnormal_embryo_hatching1.33728713
54MP0005257_abnormal_intraocular_pressure1.33293584
55MP0002282_abnormal_trachea_morphology1.32668696
56MP0002733_abnormal_thermal_nociception1.32633775
57MP0001968_abnormal_touch/_nociception1.32444255
58MP0010030_abnormal_orbit_morphology1.32424162
59MP0005409_darkened_coat_color1.31092658
60MP0002909_abnormal_adrenal_gland1.30178747
61MP0003755_abnormal_palate_morphology1.28348058
62MP0000534_abnormal_ureter_morphology1.28018029
63MP0000762_abnormal_tongue_morphology1.27609073
64MP0004858_abnormal_nervous_system1.26355141
65MP0010386_abnormal_urinary_bladder1.26078270
66MP0002160_abnormal_reproductive_system1.25623259
67MP0010771_integument_phenotype1.23301772
68MP0004811_abnormal_neuron_physiology1.19266863
69MP0002177_abnormal_outer_ear1.18869469
70MP0001216_abnormal_epidermal_layer1.18437561
71MP0005187_abnormal_penis_morphology1.14828931
72MP0003861_abnormal_nervous_system1.14079130
73MP0003315_abnormal_perineum_morphology1.13316353
74MP0003880_abnormal_central_pattern1.12012420
75MP0002572_abnormal_emotion/affect_behav1.11155673
76MP0001919_abnormal_reproductive_system1.10434766
77MP0005508_abnormal_skeleton_morphology1.09967621
78MP0003937_abnormal_limbs/digits/tail_de1.09502214
79MP0002089_abnormal_postnatal_growth/wei1.08415426
80MP0002116_abnormal_craniofacial_bone1.08198211
81MP0009053_abnormal_anal_canal1.07859271
82MP0000566_synostosis1.07614190
83MP0002697_abnormal_eye_size1.07054690
84MP0000647_abnormal_sebaceous_gland1.06828592
85MP0002822_catalepsy1.06764183
86MP0000631_abnormal_neuroendocrine_gland1.06532996
87MP0000955_abnormal_spinal_cord1.06021614
88MP0001727_abnormal_embryo_implantation1.05330764
89MP0002736_abnormal_nociception_after1.05061213
90MP0005423_abnormal_somatic_nervous1.04977043
91MP0003936_abnormal_reproductive_system1.04775776
92MP0003091_abnormal_cell_migration1.04702217
93MP0008932_abnormal_embryonic_tissue1.04468644
94MP0001881_abnormal_mammary_gland1.03195811
95MP0009703_decreased_birth_body1.03174692
96MP0001970_abnormal_pain_threshold1.03142278
97MP0003566_abnormal_cell_adhesion1.02878968
98MP0000733_abnormal_muscle_development1.02406783
99MP0001186_pigmentation_phenotype1.00867824
100MP0001958_emphysema0.99744436
101MP0002653_abnormal_ependyma_morphology0.99407547
102MP0000049_abnormal_middle_ear0.98783420
103MP0009384_cardiac_valve_regurgitation0.98386130
104MP0000371_diluted_coat_color0.98248008
105MP0001348_abnormal_lacrimal_gland0.98011224
106MP0003279_aneurysm0.97124411
107MP0003115_abnormal_respiratory_system0.96722846
108MP0002932_abnormal_joint_morphology0.96497414
109MP0002882_abnormal_neuron_morphology0.95819131
110MP0009780_abnormal_chondrocyte_physiolo0.95019997
111MP0002557_abnormal_social/conspecific_i0.94673069
112MP0005646_abnormal_pituitary_gland0.93117996
113MP0002152_abnormal_brain_morphology0.92981984
114MP0008789_abnormal_olfactory_epithelium0.92952655
115MP0004134_abnormal_chest_morphology0.92886273
116MP0004272_abnormal_basement_membrane0.92805577
117MP0010094_abnormal_chromosome_stability0.91304716
118MP0005076_abnormal_cell_differentiation0.90577899
119MP0008260_abnormal_autophagy0.90364745
120MP0001440_abnormal_grooming_behavior0.90204667
121MP0002234_abnormal_pharynx_morphology0.89017923
122MP0000428_abnormal_craniofacial_morphol0.89001846
123MP0002075_abnormal_coat/hair_pigmentati0.88804488
124MP0004957_abnormal_blastocyst_morpholog0.88379985
125MP0003705_abnormal_hypodermis_morpholog0.88231657
126MP0001177_atelectasis0.87871696
127MP0002938_white_spotting0.87030639
128MP0003283_abnormal_digestive_organ0.86958141
129MP0002295_abnormal_pulmonary_circulatio0.85040857
130MP0002109_abnormal_limb_morphology0.84794943
131MP0003935_abnormal_craniofacial_develop0.84416951
132MP0002081_perinatal_lethality0.80983157
133MP0001529_abnormal_vocalization0.80380756
134MP0004233_abnormal_muscle_weight0.79750543
135MP0009745_abnormal_behavioral_response0.79737768
136MP0002064_seizures0.79376255
137MP0001340_abnormal_eyelid_morphology0.79290539
138MP0002896_abnormal_bone_mineralization0.79210271
139MP0010307_abnormal_tumor_latency0.78866310
140MP0002233_abnormal_nose_morphology0.77866604
141MP0004742_abnormal_vestibular_system0.77429872
142MP0008057_abnormal_DNA_replication0.77064717
143MP0003890_abnormal_embryonic-extraembry0.76890222
144MP0002877_abnormal_melanocyte_morpholog0.76814986
145MP0004197_abnormal_fetal_growth/weight/0.76785232
146MP0005171_absent_coat_pigmentation0.75957888
147MP0008007_abnormal_cellular_replicative0.75480835
148MP0004185_abnormal_adipocyte_glucose0.75303477
149MP0002085_abnormal_embryonic_tissue0.75113737
150MP0002114_abnormal_axial_skeleton0.75072891
151MP0009046_muscle_twitch0.75004353
152MP0002108_abnormal_muscle_morphology0.74499927
153MP0005394_taste/olfaction_phenotype0.74018750
154MP0005499_abnormal_olfactory_system0.74018750
155MP0001984_abnormal_olfaction0.73964445
156MP0000013_abnormal_adipose_tissue0.72406335
157MP0002084_abnormal_developmental_patter0.72375977
158MP0003329_amyloid_beta_deposits0.71559457
159MP0002113_abnormal_skeleton_development0.70638042
160MP0000432_abnormal_head_morphology0.70424964
161MP0005197_abnormal_uvea_morphology0.70042105
162MP0001697_abnormal_embryo_size0.69568634
163MP0008995_early_reproductive_senescence0.68496481
164MP0003453_abnormal_keratinocyte_physiol0.68483994

Predicted human phenotypes

RankGene SetZ-score
1J-shaped sella turcica (HP:0002680)4.71402918
2Abnormality of nail color (HP:0100643)4.00472628
3Septate vagina (HP:0001153)3.54840917
4Aplasia/Hypoplasia of the frontal sinuses (HP:0009119)3.19782316
5Breast carcinoma (HP:0003002)3.17039633
6Micronodular cirrhosis (HP:0001413)3.10587353
7Premature rupture of membranes (HP:0001788)3.10006798
8Sparse lateral eyebrow (HP:0005338)2.92154147
9Deep philtrum (HP:0002002)2.88862471
10Hypopigmentation of the fundus (HP:0007894)2.88736063
11Deformed sella turcica (HP:0002681)2.86234847
12Chromosomal breakage induced by crosslinking agents (HP:0003221)2.82106318
13Germ cell neoplasia (HP:0100728)2.81502192
14Protrusio acetabuli (HP:0003179)2.75787931
15Curly hair (HP:0002212)2.75689079
16Chromsome breakage (HP:0040012)2.65745585
17Abnormality of the frontal sinuses (HP:0002687)2.58393472
18Aplasia/Hypoplasia involving the sinuses (HP:0009120)2.53153239
19Concave nail (HP:0001598)2.45944115
20Arterial tortuosity (HP:0005116)2.44178470
21Vascular tortuosity (HP:0004948)2.43960246
22Abnormality of dentin (HP:0010299)2.42522579
23Long toe (HP:0010511)2.40699154
24Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)2.40576136
25Short 4th metacarpal (HP:0010044)2.40576136
26Shallow orbits (HP:0000586)2.39832335
27Onycholysis (HP:0001806)2.33932986
28Bladder diverticulum (HP:0000015)2.30757570
29Fragile nails (HP:0001808)2.30275489
30Flat acetabular roof (HP:0003180)2.22580787
31Agitation (HP:0000713)2.20568657
32Pterygium (HP:0001059)2.16130887
33Cutaneous melanoma (HP:0012056)2.14307019
34Milia (HP:0001056)2.11647166
35Wrist flexion contracture (HP:0001239)2.10023607
36Hypoventilation (HP:0002791)2.07374188
37Morphological abnormality of the middle ear (HP:0008609)2.05429407
38Broad face (HP:0000283)2.04192930
39Soft skin (HP:0000977)2.03919659
40Bowel diverticulosis (HP:0005222)2.03189414
41Shoulder girdle muscle weakness (HP:0003547)2.02755791
42Back pain (HP:0003418)2.02585369
43Limb dystonia (HP:0002451)2.01656934
44Genu recurvatum (HP:0002816)2.01109844
45Amyotrophic lateral sclerosis (HP:0007354)2.00728412
46Aortic dissection (HP:0002647)1.99445113
47Abnormality of the sella turcica (HP:0002679)1.98756189
48Right ventricular cardiomyopathy (HP:0011663)1.97604949
49Heterochromia iridis (HP:0001100)1.95486365
50Advanced eruption of teeth (HP:0006288)1.95204260
51Fibular aplasia (HP:0002990)1.91409118
52Buphthalmos (HP:0000557)1.91285805
53Pili torti (HP:0003777)1.89150468
54Decreased number of large peripheral myelinated nerve fibers (HP:0003387)1.88497662
55Selective tooth agenesis (HP:0001592)1.88454694
56Renal duplication (HP:0000075)1.86690114
57Cervical subluxation (HP:0003308)1.85774019
58Dilatation of the ascending aorta (HP:0005111)1.85305996
59Microglossia (HP:0000171)1.85100302
60Neoplasm of the thyroid gland (HP:0100031)1.82973080
61Wormian bones (HP:0002645)1.82462690
62Elevated circulating parathyroid hormone (PTH) level (HP:0003165)1.82389072
63Mutism (HP:0002300)1.82079282
64Focal seizures (HP:0007359)1.81984838
65Severe Myopia (HP:0011003)1.80720137
66Hypoplasia of the brainstem (HP:0002365)1.80181724
67Aplasia/Hypoplasia of the brainstem (HP:0007362)1.80181724
68Nephroblastoma (Wilms tumor) (HP:0002667)1.78648806
69Papillary thyroid carcinoma (HP:0002895)1.78069756
70Macroorchidism (HP:0000053)1.77519273
71Lissencephaly (HP:0001339)1.77352794
72Deviation of the thumb (HP:0009603)1.76795013
73Plantar hyperkeratosis (HP:0007556)1.76160429
74Spinal cord lesions (HP:0100561)1.75455171
75Syringomyelia (HP:0003396)1.75455171
76Hyperparathyroidism (HP:0000843)1.74867305
77Smooth philtrum (HP:0000319)1.74505034
78Aplasia/Hypoplasia of the vertebrae (HP:0008515)1.74448280
79Vertebral hypoplasia (HP:0008417)1.74448280
80Natal tooth (HP:0000695)1.73758265
81High pitched voice (HP:0001620)1.71878686
82Abdominal distention (HP:0003270)1.71546702
83Abnormality of the proximal phalanges of the hand (HP:0009834)1.71443682
84Abnormality of the umbilical cord (HP:0010881)1.71386869
85Uterine leiomyosarcoma (HP:0002891)1.71214991
86Leiomyosarcoma (HP:0100243)1.71214991
87Broad nasal tip (HP:0000455)1.70743902
88Open mouth (HP:0000194)1.69881008
89Spinal cord compression (HP:0002176)1.69851640
90Insidious onset (HP:0003587)1.69106993
91Termporal pattern (HP:0011008)1.69106993
92Papilledema (HP:0001085)1.68455847
93Embryonal renal neoplasm (HP:0011794)1.66563802
94Broad ribs (HP:0000885)1.66384270
95Atrophic scars (HP:0001075)1.66372819
96Ankle clonus (HP:0011448)1.65850706
97Ankle contracture (HP:0006466)1.65374601
98Heterotopia (HP:0002282)1.65307717
99Enlarged penis (HP:0000040)1.64727622
100Overgrowth (HP:0001548)1.63950567
101Ridged nail (HP:0001807)1.63905573
102Absent eyelashes (HP:0000561)1.63288704
103Hereditary nonpolyposis colorectal carcinoma (HP:0006716)1.63130755
104Visual hallucinations (HP:0002367)1.62621781
105Meckel diverticulum (HP:0002245)1.62473927
106Cerebral aneurysm (HP:0004944)1.61384459
107Sacral dimple (HP:0000960)1.61274955
108Hypercortisolism (HP:0001578)1.60864046
109Dental crowding (HP:0000678)1.60706249
110Hallux valgus (HP:0001822)1.60486679
111Pseudobulbar signs (HP:0002200)1.60379674
112Vertebral arch anomaly (HP:0008438)1.59695338
113Abnormality of the 4th metacarpal (HP:0010012)1.59306628
114Deviation of the hallux (HP:0010051)1.59266087
115Increased nuchal translucency (HP:0010880)1.58901561
116Asymmetry of the thorax (HP:0001555)1.57528122
117Amelogenesis imperfecta (HP:0000705)1.57466566
118Tracheal stenosis (HP:0002777)1.57254033
119Abnormality of the distal phalanx of the thumb (HP:0009617)1.55424317
120Testicular atrophy (HP:0000029)1.55228772
121Facial cleft (HP:0002006)1.54947344
122Hyperthyroidism (HP:0000836)1.54687956
123Transitional cell carcinoma of the bladder (HP:0006740)1.54670387
124Cutaneous finger syndactyly (HP:0010554)1.54246255
125Proximal placement of thumb (HP:0009623)1.54093113
126Congenital glaucoma (HP:0001087)1.54073448
127Abnormality of the musculature of the pelvis (HP:0001469)1.53700702
128Abnormality of the hip-girdle musculature (HP:0001445)1.53700702
129Absent frontal sinuses (HP:0002688)1.53618878
130Pelvic girdle muscle weakness (HP:0003749)1.53172382
131Atrophy/Degeneration involving motor neurons (HP:0007373)1.52328058
132Abnormality of the preputium (HP:0100587)1.51932852
133Follicular hyperkeratosis (HP:0007502)1.51867115
134Bicornuate uterus (HP:0000813)1.51341003
135Renal dysplasia (HP:0000110)1.51179950
136Abnormality of the ileum (HP:0001549)1.50732499
137Myelomeningocele (HP:0002475)1.50400538
138Hand muscle atrophy (HP:0009130)1.48806806
139Atonic seizures (HP:0010819)1.48497117
140Hyperextensible skin (HP:0000974)1.48478006
141Freckling (HP:0001480)1.47390117
142Overlapping toe (HP:0001845)1.47344553
143Megalencephaly (HP:0001355)1.46372119
144Aortic aneurysm (HP:0004942)1.46118171
145Round face (HP:0000311)1.45404359
146Broad long bones (HP:0005622)1.44560316
147Neonatal short-limb short stature (HP:0008921)1.44008207
148Hyperacusis (HP:0010780)1.43880680
149Apathy (HP:0000741)1.42532518
150Thyroid carcinoma (HP:0002890)1.41678690
151Failure to thrive in infancy (HP:0001531)1.40887930
152Aqueductal stenosis (HP:0002410)1.40885992
153Inappropriate behavior (HP:0000719)1.40239145
154Menstrual irregularities (HP:0000858)1.38718869
155Adducted thumb (HP:0001181)1.38268285
156Abnormality of the odontoid process (HP:0003310)1.37941497
157Increased density of long bones (HP:0006392)1.37924986
158Fetal akinesia sequence (HP:0001989)1.37494736
159Joint laxity (HP:0001388)1.37231366
160Neoplasm of the heart (HP:0100544)1.36917469
161Mitral regurgitation (HP:0001653)1.36429857
162Short nail (HP:0001799)1.36176566
163Midline defect of the nose (HP:0004122)1.35795426
164Exostoses (HP:0100777)1.35452498
165Cerebral inclusion bodies (HP:0100314)1.35280871
166Broad phalanx (HP:0006009)1.34449895
167Broad distal phalanx of finger (HP:0009836)1.34241738
168Male infertility (HP:0003251)1.33231172
169Exotropia (HP:0000577)1.33110215
170Rhinitis (HP:0012384)1.32614450
171Abnormality of oral frenula (HP:0000190)1.32399062
172Thoracolumbar scoliosis (HP:0002944)1.32005217
173Testicular neoplasm (HP:0010788)1.30895758
174Aplasia/Hypoplasia of the sternum (HP:0006714)1.30869487
175Flat cornea (HP:0007720)1.30639078
176Narrow nasal bridge (HP:0000446)1.30496463
177Abnormality of the calcaneus (HP:0008364)1.30371905

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MARK14.34273788
2SIK13.94882038
3PKN23.43291014
4PIK3CA3.12085637
5LATS23.08219573
6NTRK32.97437721
7NEK62.65816814
8LIMK12.56576029
9MAP3K92.55124308
10RPS6KB22.54611578
11ERBB32.42237410
12MINK12.27869258
13NTRK22.25517218
14MUSK2.15229438
15PLK22.10729893
16DDR22.05878570
17EEF2K2.04711876
18NME22.03397405
19KSR11.98507167
20TRIM281.93868102
21PDGFRA1.93764051
22EIF2AK11.91775236
23PAK61.90865267
24TESK11.87146810
25MAPK131.86858401
26SIK21.83756724
27MAP3K41.81331316
28MAPKAPK31.79322374
29LATS11.78020623
30SRPK11.76750382
31KSR21.76254313
32DYRK21.70926846
33EPHB21.60978028
34PRKD31.58414106
35TYRO31.54595226
36PAK31.51370839
37NTRK11.49796794
38SMG11.49788428
39CHUK1.48341858
40TSSK61.47813044
41CSNK1G21.36217945
42FGFR41.31546816
43RPS6KB11.27969771
44SIK31.27820135
45SCYL21.26570476
46MAP3K61.25109058
47CSNK1G31.23434008
48PAK41.22185103
49MAP2K21.22140080
50CDK141.19709910
51CDK81.18559454
52EPHA21.17457063
53PBK1.16995643
54BMPR1B1.16682819
55RET1.15444536
56MAP2K71.15302901
57CDK71.15007359
58FER1.13099370
59MAP3K21.12580216
60CSNK1A1L1.11569288
61PTK2B1.09681750
62CDK181.09425827
63PAK21.08114167
64PRKCI1.05238860
65CDK151.02786679
66EIF2AK31.02522664
67UHMK11.01195142
68WEE11.00473674
69CDC70.98525757
70PNCK0.95357622
71TAOK10.93069194
72RPS6KA40.92367242
73ERBB40.92293292
74EIF2AK20.91431414
75TTK0.89509828
76BCR0.89217988
77CDK11A0.88916354
78EPHA30.88504463
79PDGFRB0.87857975
80RPS6KA20.85853646
81MOS0.85390588
82CDK50.84878752
83PLK30.84849812
84PTK20.83543235
85BRD40.83123223
86TRIB30.81922677
87FGFR20.81448522
88MAPKAPK50.80205103
89CASK0.79737485
90NEK10.78807128
91CAMK2G0.78176833
92PIM20.77744124
93CAMK2B0.77058950
94CSNK1G10.75764451
95IRAK30.64912815
96ILK0.64259667
97PTK60.61488718
98TGFBR10.61042245
99AKT20.60138608
100DYRK1A0.59242938
101CAMK2D0.55807178
102FGFR10.55429547
103ICK0.54210647
104MKNK10.52232067
105ALK0.52198162
106ROCK20.52176211
107GRK50.52113235
108GRK60.51595302
109DMPK0.51594972
110MARK20.51506534
111RAF10.50923482
112MTOR0.50467530
113MET0.50186362
114MAPK90.49976545
115TESK20.49781082
116MAP2K10.48424302
117STK30.48087903
118MST1R0.46286877
119ROCK10.45267855
120STK390.45190324
121CHEK20.44648850
122AURKA0.44194625
123CDK90.43988304
124CAMK2A0.43822425
125RPS6KA10.43032294
126PASK0.42508721
127CDK60.41258936
128MAP2K40.41243024
129HIPK20.41023635
130PRKCG0.38303962
131ATR0.37891331
132ADRBK10.37839595
133AURKB0.37783545
134CDK120.36988328
135PLK10.36461145
136MAPK100.35622363
137BRAF0.35143901
138MAPK80.34165922
139FES0.34070927
140PRKCH0.33875547
141BRSK10.33799791
142TTN0.33636806
143TAF10.33529597
144CSNK1D0.33260848
145CDK10.32473387
146MAP3K120.32061543
147MAP3K50.30763853
148CSNK1E0.30687629
149ARAF0.29987731
150MAPKAPK20.27790896
151PRKD10.27353720
152BUB10.26973369
153DYRK30.26594789

Predicted pathways (KEGG)

RankGene SetZ-score
1Steroid biosynthesis_Homo sapiens_hsa001001.86663370
2Central carbon metabolism in cancer_Homo sapiens_hsa052301.83687388
3Longevity regulating pathway - multiple species_Homo sapiens_hsa042131.82851160
4AMPK signaling pathway_Homo sapiens_hsa041521.69772702
5Axon guidance_Homo sapiens_hsa043601.66973291
6Synaptic vesicle cycle_Homo sapiens_hsa047211.65165273
7Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.51247097
8Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.50243614
9Longevity regulating pathway - mammal_Homo sapiens_hsa042111.43395673
10Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.43151871
11Colorectal cancer_Homo sapiens_hsa052101.41021261
12Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.33397316
13Dopaminergic synapse_Homo sapiens_hsa047281.33060137
14Nicotine addiction_Homo sapiens_hsa050331.32195120
15Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.29900782
16Glioma_Homo sapiens_hsa052141.29570759
17Long-term depression_Homo sapiens_hsa047301.28621623
18Vibrio cholerae infection_Homo sapiens_hsa051101.26482002
19RNA transport_Homo sapiens_hsa030131.25050064
20Cocaine addiction_Homo sapiens_hsa050301.25018568
21Insulin signaling pathway_Homo sapiens_hsa049101.24347995
22Oocyte meiosis_Homo sapiens_hsa041141.22849299
23Serotonergic synapse_Homo sapiens_hsa047261.22363845
24Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.22302624
25Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.22062898
26Small cell lung cancer_Homo sapiens_hsa052221.21379404
27Estrogen signaling pathway_Homo sapiens_hsa049151.19950919
28Endometrial cancer_Homo sapiens_hsa052131.19017050
29Tight junction_Homo sapiens_hsa045301.17589842
30Gap junction_Homo sapiens_hsa045401.17512244
31Non-homologous end-joining_Homo sapiens_hsa034501.15729745
32Cholinergic synapse_Homo sapiens_hsa047251.14361815
33Chronic myeloid leukemia_Homo sapiens_hsa052201.14242373
34Renal cell carcinoma_Homo sapiens_hsa052111.12636409
35GnRH signaling pathway_Homo sapiens_hsa049121.12576312
36Progesterone-mediated oocyte maturation_Homo sapiens_hsa049141.11616147
37Neurotrophin signaling pathway_Homo sapiens_hsa047221.11591261
38Long-term potentiation_Homo sapiens_hsa047201.11413016
39Circadian entrainment_Homo sapiens_hsa047131.11270967
40Hippo signaling pathway_Homo sapiens_hsa043901.11171220
41Dorso-ventral axis formation_Homo sapiens_hsa043201.08793408
42Sphingolipid metabolism_Homo sapiens_hsa006001.08754821
43ErbB signaling pathway_Homo sapiens_hsa040121.08158185
44Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.06658642
45Hedgehog signaling pathway_Homo sapiens_hsa043401.06462163
46Other types of O-glycan biosynthesis_Homo sapiens_hsa005141.06457911
47Acute myeloid leukemia_Homo sapiens_hsa052211.06190081
48MicroRNAs in cancer_Homo sapiens_hsa052061.06116059
49Amphetamine addiction_Homo sapiens_hsa050311.05751800
50Pancreatic cancer_Homo sapiens_hsa052121.05280123
51Cell cycle_Homo sapiens_hsa041101.01718200
52Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.00861176
53Regulation of lipolysis in adipocytes_Homo sapiens_hsa049231.00674195
54Glutamatergic synapse_Homo sapiens_hsa047241.00187567
55GABAergic synapse_Homo sapiens_hsa047271.00083778
56Melanogenesis_Homo sapiens_hsa049160.98474739
57TGF-beta signaling pathway_Homo sapiens_hsa043500.96513021
58Protein export_Homo sapiens_hsa030600.95890301
59Spliceosome_Homo sapiens_hsa030400.95467097
60Pentose phosphate pathway_Homo sapiens_hsa000300.93562127
61Proteoglycans in cancer_Homo sapiens_hsa052050.92323537
62Vitamin B6 metabolism_Homo sapiens_hsa007500.92187970
63VEGF signaling pathway_Homo sapiens_hsa043700.92134615
64Focal adhesion_Homo sapiens_hsa045100.91970331
65ECM-receptor interaction_Homo sapiens_hsa045120.91763380
66Wnt signaling pathway_Homo sapiens_hsa043100.91463684
67Morphine addiction_Homo sapiens_hsa050320.90804736
68Basal cell carcinoma_Homo sapiens_hsa052170.90757030
69Oxytocin signaling pathway_Homo sapiens_hsa049210.88449745
70Olfactory transduction_Homo sapiens_hsa047400.87315962
71Shigellosis_Homo sapiens_hsa051310.87301255
72Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.87100838
73Phagosome_Homo sapiens_hsa041450.87039581
74Insulin secretion_Homo sapiens_hsa049110.87022206
75Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.86863921
76Adherens junction_Homo sapiens_hsa045200.86836224
77N-Glycan biosynthesis_Homo sapiens_hsa005100.86583033
78Inositol phosphate metabolism_Homo sapiens_hsa005620.84445950
79Prolactin signaling pathway_Homo sapiens_hsa049170.83737456
80Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.83480657
81Fatty acid biosynthesis_Homo sapiens_hsa000610.82685812
82Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.82262818
83Renin secretion_Homo sapiens_hsa049240.82111828
84Melanoma_Homo sapiens_hsa052180.82023173
85AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.81605723
86Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.80647386
87Phospholipase D signaling pathway_Homo sapiens_hsa040720.80353449
88MAPK signaling pathway_Homo sapiens_hsa040100.80337070
89Biosynthesis of amino acids_Homo sapiens_hsa012300.80255315
90Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.80006792
91Endocytosis_Homo sapiens_hsa041440.79979660
92Thyroid cancer_Homo sapiens_hsa052160.79800879
93Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.79606935
94Bladder cancer_Homo sapiens_hsa052190.79408786
95Fructose and mannose metabolism_Homo sapiens_hsa000510.79261966
96Aldosterone synthesis and secretion_Homo sapiens_hsa049250.79217963
97Fanconi anemia pathway_Homo sapiens_hsa034600.79213253
98Ovarian steroidogenesis_Homo sapiens_hsa049130.78657617
99mRNA surveillance pathway_Homo sapiens_hsa030150.77458908
100mTOR signaling pathway_Homo sapiens_hsa041500.77195028
101Fatty acid elongation_Homo sapiens_hsa000620.76914701
102Choline metabolism in cancer_Homo sapiens_hsa052310.76643567
103Viral myocarditis_Homo sapiens_hsa054160.76249533
104Lysine degradation_Homo sapiens_hsa003100.74854942
105Thyroid hormone signaling pathway_Homo sapiens_hsa049190.73123133
106Fatty acid metabolism_Homo sapiens_hsa012120.72904429
107Sphingolipid signaling pathway_Homo sapiens_hsa040710.71679913
108Prostate cancer_Homo sapiens_hsa052150.70630856
109Taste transduction_Homo sapiens_hsa047420.70119758
110Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.69915913
111Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.69471960
112Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.69266778
113Collecting duct acid secretion_Homo sapiens_hsa049660.69167787
114Ras signaling pathway_Homo sapiens_hsa040140.68912506
115Non-small cell lung cancer_Homo sapiens_hsa052230.68674812
116Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.68461809
117Phosphatidylinositol signaling system_Homo sapiens_hsa040700.68129746
118Rap1 signaling pathway_Homo sapiens_hsa040150.67804570
119Regulation of actin cytoskeleton_Homo sapiens_hsa048100.67342454
120Insulin resistance_Homo sapiens_hsa049310.67146894
121Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.67105071
122Alcoholism_Homo sapiens_hsa050340.66234620
123Amoebiasis_Homo sapiens_hsa051460.65033333
124Dilated cardiomyopathy_Homo sapiens_hsa054140.64475879
125p53 signaling pathway_Homo sapiens_hsa041150.64347052
126Salmonella infection_Homo sapiens_hsa051320.63640132
127Gastric acid secretion_Homo sapiens_hsa049710.63095721
128Pathways in cancer_Homo sapiens_hsa052000.62809662
129Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.62256890
130Proteasome_Homo sapiens_hsa030500.62209053
131Type II diabetes mellitus_Homo sapiens_hsa049300.60919712
132Hepatitis C_Homo sapiens_hsa051600.58673538
133PI3K-Akt signaling pathway_Homo sapiens_hsa041510.58236339
134Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.57632599
135Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.54725441
136Glucagon signaling pathway_Homo sapiens_hsa049220.54612413
137Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.53708907
138HIF-1 signaling pathway_Homo sapiens_hsa040660.52098005
139Thyroid hormone synthesis_Homo sapiens_hsa049180.49571269
140Nucleotide excision repair_Homo sapiens_hsa034200.48763583
141Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.47205701
142Notch signaling pathway_Homo sapiens_hsa043300.44849476
143Base excision repair_Homo sapiens_hsa034100.44439883
144FoxO signaling pathway_Homo sapiens_hsa040680.41924954

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