SLC39A7

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene transports zinc from the Golgi and endoplasmic reticulum to the cytoplasm. This transport may be important for activation of tyrosine kinases, some of which could be involved in cancer progression. Therefore, modulation of the encoded protein could be useful as a therapeutic agent against cancer. Alternative splicing results in multiple transcript variants. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1Golgi transport vesicle coating (GO:0048200)9.87542919
2COPI coating of Golgi vesicle (GO:0048205)9.87542919
3maintenance of protein localization in endoplasmic reticulum (GO:0035437)7.50278016
4protein retention in ER lumen (GO:0006621)6.80568192
5activation of signaling protein activity involved in unfolded protein response (GO:0006987)6.13550842
6positive regulation of nuclease activity (GO:0032075)5.91053760
7retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)5.63848294
8COPII vesicle coating (GO:0048208)5.60248675
9regulation of nuclease activity (GO:0032069)5.34792760
10endoplasmic reticulum unfolded protein response (GO:0030968)5.34138463
11cellular response to unfolded protein (GO:0034620)5.12513549
12exocrine pancreas development (GO:0031017)5.01736734
13ER-nucleus signaling pathway (GO:0006984)4.90145264
14cellular response to topologically incorrect protein (GO:0035967)4.88046786
154-hydroxyproline metabolic process (GO:0019471)4.73624097
16protein maturation by protein folding (GO:0022417)4.45292263
17vesicle coating (GO:0006901)4.39891563
18response to endoplasmic reticulum stress (GO:0034976)4.33761671
19ER-associated ubiquitin-dependent protein catabolic process (GO:0030433)4.20757390
20peptidyl-proline hydroxylation (GO:0019511)4.11547227
21apoptotic cell clearance (GO:0043277)3.99250917
22response to unfolded protein (GO:0006986)3.98473440
23response to topologically incorrect protein (GO:0035966)3.83916901
24protein localization to endosome (GO:0036010)3.83765206
25protein hydroxylation (GO:0018126)3.72267736
26peptidyl-asparagine modification (GO:0018196)3.68528414
27L-alpha-amino acid transmembrane transport (GO:1902475)3.68513752
28protein N-linked glycosylation via asparagine (GO:0018279)3.67595428
29proline biosynthetic process (GO:0006561)3.64939333
30maternal placenta development (GO:0001893)3.61106740
31folic acid-containing compound biosynthetic process (GO:0009396)3.59271883
32sequestering of metal ion (GO:0051238)3.45249502
33regulation of early endosome to late endosome transport (GO:2000641)3.43742891
34planar cell polarity pathway involved in neural tube closure (GO:0090179)3.39983264
35skin morphogenesis (GO:0043589)3.37643612
36desmosome organization (GO:0002934)3.36311922
37protein N-linked glycosylation (GO:0006487)3.34418343
38polarized epithelial cell differentiation (GO:0030859)3.33368031
39cell-substrate junction assembly (GO:0007044)3.30406050
40regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway (GO:19022353.29889283
41endocrine pancreas development (GO:0031018)3.28009767
42negative regulation of cell size (GO:0045792)3.27886757
43adherens junction assembly (GO:0034333)3.26695694
44hemidesmosome assembly (GO:0031581)3.23528502
45intestinal cholesterol absorption (GO:0030299)3.21578434
46regulation of extracellular matrix disassembly (GO:0010715)3.19386835
47cell-substrate adherens junction assembly (GO:0007045)3.16656788
48focal adhesion assembly (GO:0048041)3.16656788
49cellular response to vitamin D (GO:0071305)3.12537610
50regulation of translational fidelity (GO:0006450)3.10625748
51barbed-end actin filament capping (GO:0051016)3.10468946
52regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)3.09245962
53cytoskeletal anchoring at plasma membrane (GO:0007016)3.08066195
54Golgi organization (GO:0007030)3.06898657
55regulation of cholesterol homeostasis (GO:2000188)3.06878478
56cellular response to vitamin (GO:0071295)3.05135687
57collagen fibril organization (GO:0030199)3.03491579
58cellular response to nutrient (GO:0031670)3.01178729
59protein autoprocessing (GO:0016540)2.98609648
60signal peptide processing (GO:0006465)2.98270652
61proline metabolic process (GO:0006560)2.96904115
62protein heterotrimerization (GO:0070208)2.96088073
63pinocytosis (GO:0006907)2.94927928
64tricarboxylic acid metabolic process (GO:0072350)2.91861598
65pentose-phosphate shunt (GO:0006098)2.90647906
66very-low-density lipoprotein particle assembly (GO:0034379)2.90356919
67regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)2.89173085
68low-density lipoprotein particle clearance (GO:0034383)2.87070640
69glucose 6-phosphate metabolic process (GO:0051156)2.85233616
70positive regulation of extracellular matrix organization (GO:1903055)2.84976749
71UDP-N-acetylglucosamine metabolic process (GO:0006047)2.83963902
72peptide hormone processing (GO:0016486)2.83456133
73valine metabolic process (GO:0006573)2.83324901
74endodermal cell differentiation (GO:0035987)2.83279768
75maintenance of protein localization in organelle (GO:0072595)2.82234984
76chondrocyte proliferation (GO:0035988)2.82042581
77negative regulation of fatty acid transport (GO:2000192)2.80960869
78ER to Golgi vesicle-mediated transport (GO:0006888)2.79041968
79branching involved in mammary gland duct morphogenesis (GO:0060444)2.78832808
80basement membrane organization (GO:0071711)2.75226971
81stress fiber assembly (GO:0043149)2.75213137
82establishment of apical/basal cell polarity (GO:0035089)2.70214572
83regulation of vascular endothelial growth factor signaling pathway (GO:1900746)2.69208168
84positive regulation of blood vessel endothelial cell migration (GO:0043536)2.68812659
85semaphorin-plexin signaling pathway (GO:0071526)2.67497339
86regulation of cholesterol biosynthetic process (GO:0045540)2.67160960
87positive regulation of histone deacetylation (GO:0031065)2.66916096
88regulation of type B pancreatic cell apoptotic process (GO:2000674)2.64128350
89regulation of mammary gland epithelial cell proliferation (GO:0033599)2.63969735
90dichotomous subdivision of an epithelial terminal unit (GO:0060600)2.63006176
91membrane protein ectodomain proteolysis (GO:0006509)2.62603762
92regulation of plasminogen activation (GO:0010755)2.62050378
93sulfur amino acid catabolic process (GO:0000098)2.62049580
94positive regulation of triglyceride biosynthetic process (GO:0010867)2.62016403
95embryo implantation (GO:0007566)2.60378477
96keratan sulfate catabolic process (GO:0042340)2.60064380
97regulation of fatty acid beta-oxidation (GO:0031998)2.59867180
98epithelial cell differentiation involved in prostate gland development (GO:0060742)2.58865585
99hyaluronan catabolic process (GO:0030214)2.58713076
100insulin-like growth factor receptor signaling pathway (GO:0048009)2.58175563
101NADPH regeneration (GO:0006740)2.57832078
102toxin metabolic process (GO:0009404)2.57152103
103activation of Rac GTPase activity (GO:0032863)2.56642422
104regulation of apoptotic cell clearance (GO:2000425)2.55176193
105positive regulation of glycogen biosynthetic process (GO:0045725)2.54874501
106protein-lipid complex assembly (GO:0065005)2.54820612
107plasma lipoprotein particle assembly (GO:0034377)2.54051787
108mannose metabolic process (GO:0006013)2.53412258
109intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress (GO:0070059)2.53261195
110macroautophagy (GO:0016236)2.52970347
111positive regulation of osteoblast proliferation (GO:0033690)2.52819067
112ER overload response (GO:0006983)2.52432832
113embryonic process involved in female pregnancy (GO:0060136)2.52002535
114regulation of glucose import in response to insulin stimulus (GO:2001273)2.51708055
115astrocyte differentiation (GO:0048708)2.49442225
116cell adhesion mediated by integrin (GO:0033627)2.48065653
117regulation of extracellular matrix organization (GO:1903053)2.47954235
118multicellular organismal macromolecule metabolic process (GO:0044259)2.47772562
119negative regulation of fibrinolysis (GO:0051918)2.47404025
120positive regulation of membrane protein ectodomain proteolysis (GO:0051044)2.46488613
121tooth mineralization (GO:0034505)2.45214388
122glandular epithelial cell development (GO:0002068)2.45138126
123endothelial cell morphogenesis (GO:0001886)2.42703188
124epithelial cell-cell adhesion (GO:0090136)2.42078171
125type B pancreatic cell development (GO:0003323)2.42067590
126glutamine family amino acid biosynthetic process (GO:0009084)2.41404415
127glucose catabolic process (GO:0006007)2.40731637
128negative regulation of glycoprotein biosynthetic process (GO:0010561)2.40704602
129negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)2.40356445
130intestinal absorption (GO:0050892)2.39914063
131antigen processing and presentation of endogenous peptide antigen (GO:0002483)2.39665675
132antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)2.39665675
133adhesion of symbiont to host (GO:0044406)2.39044657
134endothelial cell chemotaxis (GO:0035767)2.38733278
135collagen catabolic process (GO:0030574)2.38653362
136regulation of ER to Golgi vesicle-mediated transport (GO:0060628)2.38373117
137cerebellar Purkinje cell layer development (GO:0021680)2.38176823
138negative regulation of chondrocyte differentiation (GO:0032331)2.37806789
139nucleotide-sugar biosynthetic process (GO:0009226)2.36774432
140pteridine-containing compound biosynthetic process (GO:0042559)2.36469381
141vascular endothelial growth factor receptor signaling pathway (GO:0048010)2.36451162
142glandular epithelial cell differentiation (GO:0002067)2.35651261
143cellular copper ion homeostasis (GO:0006878)2.33841387
144regulation of fibrinolysis (GO:0051917)2.33774445
145cellular modified amino acid catabolic process (GO:0042219)2.33760105
146cellular zinc ion homeostasis (GO:0006882)2.33552357
147surfactant homeostasis (GO:0043129)2.32985862
148extracellular matrix disassembly (GO:0022617)2.32919692
149Wnt signaling pathway, planar cell polarity pathway (GO:0060071)2.32468180
150collagen metabolic process (GO:0032963)2.32229118
151peptide catabolic process (GO:0043171)2.30264214
152peptidyl-glutamic acid carboxylation (GO:0017187)2.29501026
153protein carboxylation (GO:0018214)2.29501026

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TP63_17297297_ChIP-ChIP_HaCaT_Human3.43357157
2FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse3.21998196
3CLOCK_20551151_ChIP-Seq_293T_Human3.16080425
4* ESR1_17901129_ChIP-ChIP_LIVER_Mouse3.15051141
5RARG_19884340_ChIP-ChIP_MEFs_Mouse3.02238760
6PPARG_19300518_ChIP-PET_3T3-L1_Mouse2.67416464
7NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.60399363
8EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.44891830
9EGR1_19374776_ChIP-ChIP_THP-1_Human2.44076946
10TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse2.36230635
11TRIM28_21343339_ChIP-Seq_HEK293_Human2.33839811
12PPARA_22158963_ChIP-Seq_LIVER_Mouse2.32001757
13RXR_22158963_ChIP-Seq_LIVER_Mouse2.30587124
14MYC_22102868_ChIP-Seq_BL_Human2.17381672
15THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse2.13883654
16PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse2.08883080
17LXR_22292898_ChIP-Seq_THP-1_Human2.02318907
18ELK3_25401928_ChIP-Seq_HUVEC_Human1.99000198
19TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.98007676
20TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.96947974
21TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.88037662
22ATF3_27146783_Chip-Seq_COLON_Human1.82139295
23AR_21909140_ChIP-Seq_LNCAP_Human1.82085015
24STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.78936931
25RACK7_27058665_Chip-Seq_MCF-7_Human1.75614218
26RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.75011746
27E2F7_22180533_ChIP-Seq_HELA_Human1.74257541
28TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.73955536
29LXR_22158963_ChIP-Seq_LIVER_Mouse1.73206299
30DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.72813763
31ZNF263_19887448_ChIP-Seq_K562_Human1.66422222
32HIF1A_21447827_ChIP-Seq_MCF-7_Human1.63991031
33KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.58347937
34SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.55157068
35VDR_21846776_ChIP-Seq_THP-1_Human1.54984456
36FOXM1_23109430_ChIP-Seq_U2OS_Human1.54188654
37NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.48419716
38ESR2_21235772_ChIP-Seq_MCF-7_Human1.47367125
39ESR1_21235772_ChIP-Seq_MCF-7_Human1.44440732
40EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.43711641
41SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.43604575
42MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.43386351
43KDM2B_26808549_Chip-Seq_K562_Human1.43271068
44P300_27058665_Chip-Seq_ZR-75-30cells_Human1.42588048
45TFEB_21752829_ChIP-Seq_HELA_Human1.42409378
46TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.41688738
47GATA1_22025678_ChIP-Seq_K562_Human1.38647568
48* ZFX_18555785_ChIP-Seq_MESCs_Mouse1.37507038
49POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.36258010
50SOX2_27498859_Chip-Seq_STOMACH_Mouse1.35152319
51ZFP281_18757296_ChIP-ChIP_E14_Mouse1.34616817
52* CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.34553053
53CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.34105821
54ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.33885206
55FOXP2_23625967_ChIP-Seq_PFSK-1_AND_SK-N-MC_Human1.31799951
56KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.31001875
57KDM2B_26808549_Chip-Seq_DND41_Human1.30777196
58* MYC_18555785_ChIP-Seq_MESCs_Mouse1.30749136
59* DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.30053388
60ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.29108541
61ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.27857872
62KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.26615581
63KDM2B_26808549_Chip-Seq_SUP-B15_Human1.24918646
64CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.22224755
65KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.20388217
66CHD1_26751641_Chip-Seq_LNCaP_Human1.19958831
67CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.19727633
68NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.18272455
69ATF3_23680149_ChIP-Seq_GBM1-GSC_Human1.17845558
70* PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.17017009
71CREB1_26743006_Chip-Seq_LNCaP_Human1.16919275
72SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.15309235
73SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.15309235
74STAT6_21828071_ChIP-Seq_BEAS2B_Human1.15054309
75TCF7_22412390_ChIP-Seq_EML_Mouse1.14664941
76HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.14223122
77SREBP1_19666523_ChIP-Seq_LIVER_Mouse1.14100505
78ELF1_20517297_ChIP-Seq_JURKAT_Human1.13147346
79STAT3_1855785_ChIP-Seq_MESCs_Mouse1.12818873
80EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.12520783
81HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.12344833
82CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.12216272
83UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.12123311
84ERG_21242973_ChIP-ChIP_JURKAT_Human1.11162330
85KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.10560103
86CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.10473843
87E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.10469518
88NCOR1_26117541_ChIP-Seq_K562_Human1.08758568
89FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.07518570
90RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.06951283
91GATA6_25053715_ChIP-Seq_YYC3_Human1.06451128
92* TP53_22127205_ChIP-Seq_IMR90_Human1.05284743
93KLF4_18555785_ChIP-Seq_MESCs_Mouse1.04693219
94SOX9_24532713_ChIP-Seq_HFSC_Mouse1.04635342
95P68_20966046_ChIP-Seq_HELA_Human1.04049695
96TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.04023061
97CTCF_27219007_Chip-Seq_ERYTHROID_Human1.03788952
98TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.03461210
99XRN2_22483619_ChIP-Seq_HELA_Human1.02834836
100SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.01440045
101NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.01300368
102ZFP281_18358816_ChIP-ChIP_MESCs_Mouse0.99929293
103SREBP2_21459322_ChIP-Seq_LIVER_Mouse0.99405635
104WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse0.99064381
105TET1_21451524_ChIP-Seq_MESCs_Mouse0.98669478
106ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.97699590
107NANOG_18700969_ChIP-ChIP_MESCs_Mouse0.96039840
108UBF1/2_26484160_Chip-Seq_HMECs_Human0.95633978
109HNF4A_19761587_ChIP-ChIP_CACO-2_Human0.94706298
110ZFP281_27345836_Chip-Seq_ESCs_Mouse0.94213181
111EOMES_20176728_ChIP-ChIP_TSCs_Mouse0.92911142
112UTX_26944678_Chip-Seq_JUKART_Human0.92779821
113P63_26484246_Chip-Seq_KERATINOCYTES_Human0.92118213
114* MYC_19079543_ChIP-ChIP_MESCs_Mouse0.91851398
115ESR1_15608294_ChIP-ChIP_MCF-7_Human0.91808185
116RUNX1_27514584_Chip-Seq_MCF-7_Human0.91787268
117NELFA_20434984_ChIP-Seq_ESCs_Mouse0.91450418
118TBX20_22328084_ChIP-Seq_HEART_Mouse0.90892351
119TBX20_22080862_ChIP-Seq_HEART_Mouse0.90892351
120NKX2-5_21415370_ChIP-Seq_HL-1_Mouse0.90626067
121FOXO3_23340844_ChIP-Seq_DLD1_Human0.90437414
122NFIB_24661679_ChIP-Seq_LUNG_Mouse0.89726739
123* DMRT1_23473982_ChIP-Seq_TESTES_Mouse0.89610969
124TAL1_20887958_ChIP-Seq_HPC-7_Mouse0.87914764
125SA1_27219007_Chip-Seq_ERYTHROID_Human0.87610268
126GATA3_20176728_ChIP-ChIP_TSCs_Mouse0.87333989
127NOTCH1_17114293_ChIP-ChIP_T-ALL_Human0.87333247

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008438_abnormal_cutaneous_collagen5.03782011
2MP0003705_abnormal_hypodermis_morpholog4.06300009
3MP0003283_abnormal_digestive_organ3.43981854
4MP0006054_spinal_hemorrhage2.92787181
5MP0005275_abnormal_skin_tensile2.81326870
6MP0005220_abnormal_exocrine_pancreas2.68740224
7MP0000013_abnormal_adipose_tissue2.55308676
8MP0002877_abnormal_melanocyte_morpholog2.47139342
9MP0005451_abnormal_body_composition2.32458703
10MP0005083_abnormal_biliary_tract2.17276157
11MP0003566_abnormal_cell_adhesion2.12784840
12MP0003300_gastrointestinal_ulcer2.10885399
13MP0004272_abnormal_basement_membrane2.06481143
14MP0010352_gastrointestinal_tract_polyps1.92755072
15MP0001944_abnormal_pancreas_morphology1.91782203
16MP0005058_abnormal_lysosome_morphology1.90797877
17MP0010234_abnormal_vibrissa_follicle1.90502072
18MP0005503_abnormal_tendon_morphology1.89970940
19MP0003279_aneurysm1.85330021
20MP0009840_abnormal_foam_cell1.76205608
21MP0000003_abnormal_adipose_tissue1.75499723
22MP0001666_abnormal_nutrient_absorption1.74393169
23MP0005365_abnormal_bile_salt1.71586543
24MP0005257_abnormal_intraocular_pressure1.67857069
25MP0002896_abnormal_bone_mineralization1.62915807
26MP0002139_abnormal_hepatobiliary_system1.61242935
27MP0009780_abnormal_chondrocyte_physiolo1.61226947
28MP0003195_calcinosis1.58708360
29MP0005023_abnormal_wound_healing1.58295220
30MP0001958_emphysema1.57657752
31MP0005409_darkened_coat_color1.57065435
32MP0003941_abnormal_skin_development1.55316594
33MP0002693_abnormal_pancreas_physiology1.52377952
34MP0009384_cardiac_valve_regurgitation1.50413032
35MP0002909_abnormal_adrenal_gland1.48141660
36MP0004264_abnormal_extraembryonic_tissu1.46492415
37MP0005076_abnormal_cell_differentiation1.45067308
38MP0003453_abnormal_keratinocyte_physiol1.40451904
39MP0003806_abnormal_nucleotide_metabolis1.27268133
40MP0002060_abnormal_skin_morphology1.27131914
41MP0003252_abnormal_bile_duct1.26715615
42MP0008260_abnormal_autophagy1.24751246
43MP0008961_abnormal_basal_metabolism1.23446566
44MP0010030_abnormal_orbit_morphology1.22565653
45MP0002796_impaired_skin_barrier1.22325985
46MP0001915_intracranial_hemorrhage1.21115070
47MP0001849_ear_inflammation1.20036571
48MP0009643_abnormal_urine_homeostasis1.19027020
49MP0010368_abnormal_lymphatic_system1.18797378
50MP0003091_abnormal_cell_migration1.18386253
51MP0005375_adipose_tissue_phenotype1.17781761
52MP0005508_abnormal_skeleton_morphology1.16832656
53MP0003950_abnormal_plasma_membrane1.15099895
54MP0000751_myopathy1.15070683
55MP0000537_abnormal_urethra_morphology1.14343769
56MP0003329_amyloid_beta_deposits1.13835919
57MP0003172_abnormal_lysosome_physiology1.10675258
58MP0002295_abnormal_pulmonary_circulatio1.10289543
59MP0005623_abnormal_meninges_morphology1.10092176
60MP0004043_abnormal_pH_regulation1.07488785
61MP0002089_abnormal_postnatal_growth/wei1.05824563
62MP0004185_abnormal_adipocyte_glucose1.04956389
63MP0003959_abnormal_lean_body1.04161079
64MP0000462_abnormal_digestive_system1.03533375
65MP0005501_abnormal_skin_physiology1.03482036
66MP0001730_embryonic_growth_arrest1.03400899
67MP0002078_abnormal_glucose_homeostasis1.02752618
68MP0005408_hypopigmentation1.02709251
69MP0009053_abnormal_anal_canal1.02473664
70MP0000678_abnormal_parathyroid_gland1.02267992
71MP0004233_abnormal_muscle_weight1.01643426
72MP0002234_abnormal_pharynx_morphology1.01410681
73MP0000750_abnormal_muscle_regeneration1.00788565
74MP0003183_abnormal_peptide_metabolism1.00605924
75MP0000762_abnormal_tongue_morphology0.99530538
76MP0001243_abnormal_dermal_layer0.97078861
77MP0000428_abnormal_craniofacial_morphol0.94615477
78MP0003385_abnormal_body_wall0.93426128
79MP0001756_abnormal_urination0.92927787
80MP0003868_abnormal_feces_composition0.92883347
81MP0000733_abnormal_muscle_development0.91908977
82MP0002269_muscular_atrophy0.91777351
83MP0001299_abnormal_eye_distance/0.91566634
84MP0003119_abnormal_digestive_system0.87742363
85MP0001216_abnormal_epidermal_layer0.86334483
86MP0002086_abnormal_extraembryonic_tissu0.86130035
87MP0001348_abnormal_lacrimal_gland0.86102537
88MP0005197_abnormal_uvea_morphology0.86029326
89MP0005621_abnormal_cell_physiology0.85324084
90MP0000163_abnormal_cartilage_morphology0.85056450
91MP0003045_fibrosis0.84986635
92MP0003795_abnormal_bone_structure0.84858655
93MP0004782_abnormal_surfactant_physiolog0.83931884
94MP0002837_dystrophic_cardiac_calcinosis0.82474874
95MP0001661_extended_life_span0.82201273
96MP0000467_abnormal_esophagus_morphology0.81660064
97MP0000566_synostosis0.80394723
98MP0003942_abnormal_urinary_system0.80369936
99MP0005360_urolithiasis0.80303993
100MP0000609_abnormal_liver_physiology0.79884860
101MP0002928_abnormal_bile_duct0.79585947
102MP0000534_abnormal_ureter_morphology0.79373713
103MP0002168_other_aberrant_phenotype0.78657158
104MP0005085_abnormal_gallbladder_physiolo0.77179310
105MP0000747_muscle_weakness0.77098869
106MP0004858_abnormal_nervous_system0.76865006
107MP0005165_increased_susceptibility_to0.76463490
108MP0005666_abnormal_adipose_tissue0.75263016
109MP0005390_skeleton_phenotype0.75202191
110MP0002080_prenatal_lethality0.74503242
111MP0001533_abnormal_skeleton_physiology0.74256371
112MP0010329_abnormal_lipoprotein_level0.74145505
113MP0000598_abnormal_liver_morphology0.73783741
114MP0003115_abnormal_respiratory_system0.72751719
115MP0000858_altered_metastatic_potential0.72574798
116MP0003984_embryonic_growth_retardation0.72570539
117MP0004197_abnormal_fetal_growth/weight/0.72044627
118MP0001614_abnormal_blood_vessel0.71493070
119MP0000613_abnormal_salivary_gland0.71008770
120MP0002254_reproductive_system_inflammat0.70862918
121MP0005380_embryogenesis_phenotype0.70527794
122MP0001672_abnormal_embryogenesis/_devel0.70527794
123MP0010630_abnormal_cardiac_muscle0.69951027
124MP0002933_joint_inflammation0.69721147
125MP0010386_abnormal_urinary_bladder0.69280835
126MP0000767_abnormal_smooth_muscle0.68306411
127MP0001542_abnormal_bone_strength0.68280786
128MP0005319_abnormal_enzyme/_coenzyme0.68011134
129MP0003123_paternal_imprinting0.67948091
130MP0009672_abnormal_birth_weight0.67874235
131MP0003191_abnormal_cellular_cholesterol0.67851825
132MP0002998_abnormal_bone_remodeling0.67362483
133MP0002088_abnormal_embryonic_growth/wei0.67100567
134MP0000627_abnormal_mammary_gland0.66667368
135MP0003122_maternal_imprinting0.66406972
136MP0002113_abnormal_skeleton_development0.66341724
137MP0005670_abnormal_white_adipose0.66261925
138MP0000604_amyloidosis0.66099404
139MP0005332_abnormal_amino_acid0.65979117
140MP0002115_abnormal_skeleton_extremities0.65931317
141MP0002108_abnormal_muscle_morphology0.65212687

Predicted human phenotypes

RankGene SetZ-score
1Protrusio acetabuli (HP:0003179)5.51062456
2Premature rupture of membranes (HP:0001788)5.02139958
3Cerebral aneurysm (HP:0004944)3.83730432
4Hyperinsulinemic hypoglycemia (HP:0000825)3.42832872
5Cervical subluxation (HP:0003308)3.40614014
6Hypoglycemic coma (HP:0001325)3.40560611
7Ankle contracture (HP:0006466)3.19759834
8Hypoglycemic seizures (HP:0002173)3.18100468
9Aortic dissection (HP:0002647)3.07556529
10Arterial tortuosity (HP:0005116)3.06542531
11Vascular tortuosity (HP:0004948)3.04553795
12Mucopolysacchariduria (HP:0008155)2.97111542
13Urinary glycosaminoglycan excretion (HP:0003541)2.97111542
14Shallow orbits (HP:0000586)2.95819071
15Dysostosis multiplex (HP:0000943)2.95485307
16Flat acetabular roof (HP:0003180)2.93985916
17Peritonitis (HP:0002586)2.93970942
18Hand muscle atrophy (HP:0009130)2.87577775
19Aortic aneurysm (HP:0004942)2.87390810
20Abnormality of endocrine pancreas physiology (HP:0012093)2.83694170
21Abnormality of the pancreatic islet cells (HP:0006476)2.83694170
22Hyperacusis (HP:0010780)2.82233127
23Abnormality of the intrinsic pathway (HP:0010989)2.80738130
24Bladder diverticulum (HP:0000015)2.79506530
25Late onset (HP:0003584)2.76943142
26Atrophic scars (HP:0001075)2.75735983
27Distal upper limb amyotrophy (HP:0007149)2.75117247
28Upper limb amyotrophy (HP:0009129)2.75117247
29Aneurysm (HP:0002617)2.74631177
30Elevated circulating parathyroid hormone (PTH) level (HP:0003165)2.74055405
31Vertebral compression fractures (HP:0002953)2.69790706
32Abnormality of polysaccharide metabolism (HP:0011012)2.68840591
33Abnormality of glycosaminoglycan metabolism (HP:0004371)2.68840591
34Abnormality of mucopolysaccharide metabolism (HP:0011020)2.68840591
35Soft skin (HP:0000977)2.63105388
36Ketoacidosis (HP:0001993)2.60999302
37Abnormality of carpal bone ossification (HP:0006257)2.56982397
38Dilatation of the ascending aorta (HP:0005111)2.55951071
39Blue sclerae (HP:0000592)2.51263075
40Asymmetry of the thorax (HP:0001555)2.51077638
41Long toe (HP:0010511)2.49134429
42Broad metatarsal (HP:0001783)2.41932550
43Symptomatic seizures (HP:0011145)2.40309935
44Mitral valve prolapse (HP:0001634)2.40071763
45Back pain (HP:0003418)2.38057741
46Disproportionate tall stature (HP:0001519)2.33835424
47Fragile skin (HP:0001030)2.32834986
48Congenital glaucoma (HP:0001087)2.31014334
49Short nail (HP:0001799)2.30494842
50Abnormal ossification of hand bones (HP:0005921)2.30442277
51Turricephaly (HP:0000262)2.29659391
52Thin bony cortex (HP:0002753)2.29142408
53Wormian bones (HP:0002645)2.28865566
54Genu recurvatum (HP:0002816)2.28796734
55Thoracolumbar scoliosis (HP:0002944)2.26023815
56Abnormality of dentin (HP:0010299)2.24884946
57Elbow flexion contracture (HP:0002987)2.22844429
58Osteolytic defects of the hand bones (HP:0009699)2.22407283
59Osteolytic defects of the phalanges of the hand (HP:0009771)2.22407283
60Hyperglycemia (HP:0003074)2.21867127
61Abnormal delivery (HP:0001787)2.21719375
62Bowel diverticulosis (HP:0005222)2.19904731
63Large for gestational age (HP:0001520)2.16554160
64Abnormality of the acetabulum (HP:0003170)2.14661257
65Renal duplication (HP:0000075)2.13412066
66Mildly elevated creatine phosphokinase (HP:0008180)2.13055358
67Insulin resistance (HP:0000855)2.12559815
68Ulnar bowing (HP:0003031)2.11020194
69Joint stiffness (HP:0001387)2.09368330
70Broad face (HP:0000283)2.08163033
71Coxa vara (HP:0002812)2.06985704
72Biconcave vertebral bodies (HP:0004586)2.06894553
73Mitral stenosis (HP:0001718)2.06203342
74Abnormality of the common coagulation pathway (HP:0010990)2.06133921
75Insomnia (HP:0100785)2.04288337
76Hemorrhage of the eye (HP:0011885)2.03028207
77Hyperextensible skin (HP:0000974)2.01729933
78Ankyloglossia (HP:0010296)2.00665871
79Beaking of vertebral bodies (HP:0004568)2.00017655
80Severe short stature (HP:0003510)1.99856588
81Ketosis (HP:0001946)1.99632627
82Abdominal distention (HP:0003270)1.99069815
83Abnormality of aromatic amino acid family metabolism (HP:0004338)1.98820637
84Ectopia lentis (HP:0001083)1.97395578
85Advanced eruption of teeth (HP:0006288)1.96495951
86Joint laxity (HP:0001388)1.95439174
87Nonimmune hydrops fetalis (HP:0001790)1.95039639
88Natal tooth (HP:0000695)1.95029862
89Distal lower limb amyotrophy (HP:0008944)1.94312462
90Mitral regurgitation (HP:0001653)1.93689658
91Platyspondyly (HP:0000926)1.92839729
92Spinal rigidity (HP:0003306)1.92786905
93Xanthomatosis (HP:0000991)1.91839185
94Pancreatic islet-cell hyperplasia (HP:0004510)1.91594666
95Follicular hyperkeratosis (HP:0007502)1.91251307
96Type 1 muscle fiber predominance (HP:0003803)1.91164829
97Cardiovascular calcification (HP:0011915)1.90280726
98Breech presentation (HP:0001623)1.89855692
99Insulin-resistant diabetes mellitus (HP:0000831)1.89213442
100Striae distensae (HP:0001065)1.89039352
101Increased connective tissue (HP:0009025)1.88587469
102Deep venous thrombosis (HP:0002625)1.88048371
103Skin nodule (HP:0200036)1.87065577
104Cupped ribs (HP:0000887)1.85127455
105Protuberant abdomen (HP:0001538)1.84946507
106Difficulty climbing stairs (HP:0003551)1.82939690
107Radial bowing (HP:0002986)1.82885490
108Bowed forearm bones (HP:0003956)1.82844624
109Bowing of the arm (HP:0006488)1.82844624
110Abnormality of oral frenula (HP:0000190)1.80209182
111Abnormal tarsal ossification (HP:0008369)1.79303714
112Increased variability in muscle fiber diameter (HP:0003557)1.79289952
113Abnormal hand bone ossification (HP:0010660)1.78644863
114Vacuolated lymphocytes (HP:0001922)1.78438211
115Generalized amyotrophy (HP:0003700)1.78414536
116Gout (HP:0001997)1.77525199
117Abnormality of complement system (HP:0005339)1.77108335
118Achilles tendon contracture (HP:0001771)1.76640336
119Abnormal pancreas size (HP:0012094)1.76584909
120Cholecystitis (HP:0001082)1.76397597
121Abnormal gallbladder physiology (HP:0012438)1.76397597
122Abnormal cartilage morphology (HP:0002763)1.75944986
123Myocardial infarction (HP:0001658)1.75810633
124Nuclear cataract (HP:0100018)1.73154255
125Hypercortisolism (HP:0001578)1.72720953
126Trismus (HP:0000211)1.72345096
127Abnormality of the Achilles tendon (HP:0005109)1.72054597
128Cerebral inclusion bodies (HP:0100314)1.70717701
129Spondylolisthesis (HP:0003302)1.69413461
130Lymphangioma (HP:0100764)1.69132749
131Abnormality of the distal phalanges of the toes (HP:0010182)1.68977361
132Exocrine pancreatic insufficiency (HP:0001738)1.68835649
133Premature skin wrinkling (HP:0100678)1.68083308
134Neonatal short-limb short stature (HP:0008921)1.67725903
135Enlarged penis (HP:0000040)1.67197010
136Neonatal death (HP:0003811)1.66791902
137Abnormality of the calcaneus (HP:0008364)1.66407782
138Metaphyseal cupping (HP:0003021)1.66022464
139Osteoarthritis (HP:0002758)1.65857747
140Vascular calcification (HP:0004934)1.65665902
141Missing ribs (HP:0000921)1.65008753
142Spastic diplegia (HP:0001264)1.64735993
143Osteopenia (HP:0000938)1.64089033
144Abnormal foot bone ossification (HP:0010675)1.62990175
145Distal lower limb muscle weakness (HP:0009053)1.62608873
146Long palpebral fissure (HP:0000637)1.62500716
147Hyperparathyroidism (HP:0000843)1.60466395
148Spinal cord compression (HP:0002176)1.58821044
149Small epiphyses (HP:0010585)1.57747595
150Flattened epiphyses (HP:0003071)1.57694771
151Arnold-Chiari malformation (HP:0002308)1.57597799

Predicted kinase interactions (KEA)

RankGene SetZ-score
1ERN15.47871969
2TRIB34.79934621
3PKN23.47186153
4PASK2.96923322
5SMG12.85139124
6IRAK32.71721780
7EEF2K2.62112921
8PDGFRA2.61402572
9SIK12.58312259
10SCYL22.38821991
11BCKDK2.27480077
12FLT32.23514733
13PTK62.23190562
14MST1R2.15697266
15TTN2.11241899
16DDR22.11076115
17MAP3K101.99903019
18MAPK151.79370712
19INSRR1.77846907
20EPHA21.75568557
21PTK21.70791817
22TAOK31.58639651
23PRPF4B1.56771412
24RIPK11.52029396
25MAPKAPK31.48305262
26LRRK21.45823920
27PAK41.45620194
28MET1.42205135
29FGFR41.36530803
30PAK21.33022376
31TESK11.29371136
32PRKD31.27506318
33LATS11.25833702
34NTRK11.25377082
35LMTK21.19226691
36MTOR1.15632121
37BMX1.11672369
38HIPK21.11347407
39MAP2K21.10718699
40TESK21.09304315
41EPHA31.04871473
42EPHB11.04337311
43FER1.03057045
44ARAF1.00534928
45DYRK1B1.00398850
46PIK3CG0.99259994
47MYLK0.94007130
48EIF2AK10.91399223
49FGFR30.89743953
50PAK30.89357091
51ZAP700.88360717
52LATS20.87323975
53ERBB40.87284589
54TAOK20.86410097
55RPS6KA40.86192944
56FRK0.85767431
57MAP3K30.84378499
58MAP3K20.83866110
59PDGFRB0.80301535
60CDK70.79497684
61NEK90.78467199
62RPS6KB20.77972495
63KDR0.75349470
64EIF2AK30.74891324
65PDPK10.72658269
66ICK0.71818035
67FGFR10.69612302
68RET0.68931692
69TGFBR20.68719365
70NME20.68246353
71ILK0.66040894
72MAP3K60.65210231
73TTK0.64482386
74CAMK1G0.63556990
75MAP2K30.63429709
76MAP3K80.63284167
77MAP3K10.62693822
78STK380.61715382
79MAP3K110.61375191
80MAP2K10.60711651
81JAK30.60685556
82ALK0.60657931
83KSR20.59455250
84MOS0.57165490
85CLK10.56103144
86PRKCH0.55710509
87EPHB20.55584179
88LIMK10.55528438
89BRAF0.53691549
90CDC42BPA0.53580121
91CDK120.52587761
92PRKCI0.51265673
93PIM20.49416441
94PRKD10.47595027
95PRKD20.47180381
96WNK40.47045562
97JAK10.46953519
98TGFBR10.46661661
99TRPM70.45831059
100STK100.44939668
101DMPK0.44664147
102GSK3A0.44655668
103TBK10.44131711
104MAP3K130.43505990
105AKT20.42918690
106MARK20.42617143
107ROCK20.41967254
108CAMKK10.41748794
109JAK20.41050652
110CSK0.39038801
111PBK0.38933392
112DYRK30.38904718
113NEK20.38718799
114TYRO30.37673708
115CAMK1D0.37528477
116UHMK10.36580844
117CDK80.36494487
118DAPK30.35544762
119PAK10.34785373
120CAMKK20.34710547
121TYK20.34214722
122CDK90.33257648
123BRSK10.32288878
124NEK10.30700569
125INSR0.30107224
126CDK60.29715491
127CDK40.28592597
128RPS6KL10.27586847
129RPS6KC10.27586847
130RPS6KA20.27329021
131PRKG20.26707748
132MAPK110.23934369
133TAOK10.23836235
134MAPKAPK20.23774133
135SRC0.22990333
136IGF1R0.22601370

Predicted pathways (KEGG)

RankGene SetZ-score
1Maturity onset diabetes of the young_Homo sapiens_hsa049505.14922115
2Protein processing in endoplasmic reticulum_Homo sapiens_hsa041414.05835873
3Protein export_Homo sapiens_hsa030603.35409979
4N-Glycan biosynthesis_Homo sapiens_hsa005102.31422673
5Selenocompound metabolism_Homo sapiens_hsa004502.27172503
6Sulfur metabolism_Homo sapiens_hsa009202.06240932
7Protein digestion and absorption_Homo sapiens_hsa049741.94020971
8Bladder cancer_Homo sapiens_hsa052191.79858967
9Lysosome_Homo sapiens_hsa041421.76900286
10Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.68560272
11Glycosaminoglycan degradation_Homo sapiens_hsa005311.68547614
12Fat digestion and absorption_Homo sapiens_hsa049751.67674286
13Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.57879419
14Other glycan degradation_Homo sapiens_hsa005111.56014803
15ECM-receptor interaction_Homo sapiens_hsa045121.55608729
16Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.48772914
17Folate biosynthesis_Homo sapiens_hsa007901.48266471
18Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.39609486
192-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.39171761
20Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.34285616
21Focal adhesion_Homo sapiens_hsa045101.31019102
22Tryptophan metabolism_Homo sapiens_hsa003801.27503197
23Vibrio cholerae infection_Homo sapiens_hsa051101.27042894
24Nitrogen metabolism_Homo sapiens_hsa009101.21447871
25Fatty acid degradation_Homo sapiens_hsa000711.20768503
26Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.16117474
27Fatty acid biosynthesis_Homo sapiens_hsa000611.14073622
28Galactose metabolism_Homo sapiens_hsa000521.13927311
29Insulin resistance_Homo sapiens_hsa049311.13910626
30Biosynthesis of amino acids_Homo sapiens_hsa012301.10201501
31One carbon pool by folate_Homo sapiens_hsa006701.09601574
32Prion diseases_Homo sapiens_hsa050201.08375977
33Pancreatic secretion_Homo sapiens_hsa049721.07834837
34Non-small cell lung cancer_Homo sapiens_hsa052231.07190840
35Chronic myeloid leukemia_Homo sapiens_hsa052201.05678485
36Central carbon metabolism in cancer_Homo sapiens_hsa052301.04545673
37Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.02971248
38Proteoglycans in cancer_Homo sapiens_hsa052051.00890324
39Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.98458304
40Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.96868284
41VEGF signaling pathway_Homo sapiens_hsa043700.96396066
42Amoebiasis_Homo sapiens_hsa051460.93968136
43Lysine degradation_Homo sapiens_hsa003100.93867140
44Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.93856898
45Carbohydrate digestion and absorption_Homo sapiens_hsa049730.91470064
46Thyroid hormone signaling pathway_Homo sapiens_hsa049190.90961294
47mTOR signaling pathway_Homo sapiens_hsa041500.90659168
48Renal cell carcinoma_Homo sapiens_hsa052110.90063752
49Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.89394274
50Small cell lung cancer_Homo sapiens_hsa052220.88561110
51Fatty acid metabolism_Homo sapiens_hsa012120.84852296
52Carbon metabolism_Homo sapiens_hsa012000.83802973
53Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.82576006
54Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.82208040
55Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.82120903
56Arginine and proline metabolism_Homo sapiens_hsa003300.81592912
57Sulfur relay system_Homo sapiens_hsa041220.81228007
58Caffeine metabolism_Homo sapiens_hsa002320.81056454
59Type II diabetes mellitus_Homo sapiens_hsa049300.80810120
60Renin-angiotensin system_Homo sapiens_hsa046140.80721965
61Steroid biosynthesis_Homo sapiens_hsa001000.77883719
62Thyroid hormone synthesis_Homo sapiens_hsa049180.77170988
63Glioma_Homo sapiens_hsa052140.76917938
64Arginine biosynthesis_Homo sapiens_hsa002200.76369000
65Sphingolipid metabolism_Homo sapiens_hsa006000.75240081
66Adherens junction_Homo sapiens_hsa045200.75135704
67Primary bile acid biosynthesis_Homo sapiens_hsa001200.75110846
68Regulation of actin cytoskeleton_Homo sapiens_hsa048100.74030399
69Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.73015853
70Starch and sucrose metabolism_Homo sapiens_hsa005000.72694284
71Thyroid cancer_Homo sapiens_hsa052160.72033497
72Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.70765087
73Complement and coagulation cascades_Homo sapiens_hsa046100.70748312
74AMPK signaling pathway_Homo sapiens_hsa041520.70087188
75ErbB signaling pathway_Homo sapiens_hsa040120.69864374
76Antigen processing and presentation_Homo sapiens_hsa046120.68989721
77Insulin secretion_Homo sapiens_hsa049110.68889467
78Tight junction_Homo sapiens_hsa045300.68471366
79Shigellosis_Homo sapiens_hsa051310.67728998
80Vitamin B6 metabolism_Homo sapiens_hsa007500.66405180
81Notch signaling pathway_Homo sapiens_hsa043300.66018277
82Fructose and mannose metabolism_Homo sapiens_hsa000510.65482777
83HIF-1 signaling pathway_Homo sapiens_hsa040660.64954224
84AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.64936795
85Insulin signaling pathway_Homo sapiens_hsa049100.63666035
86Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.63157224
87Hepatitis C_Homo sapiens_hsa051600.63014728
88Adipocytokine signaling pathway_Homo sapiens_hsa049200.62750086
89Hippo signaling pathway_Homo sapiens_hsa043900.59405696
90Apoptosis_Homo sapiens_hsa042100.58940283
91Longevity regulating pathway - mammal_Homo sapiens_hsa042110.58202075
92Glucagon signaling pathway_Homo sapiens_hsa049220.58124663
93Legionellosis_Homo sapiens_hsa051340.57299238
94PI3K-Akt signaling pathway_Homo sapiens_hsa041510.56681544
95Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.56652998
96Pathways in cancer_Homo sapiens_hsa052000.55706832
97Endocytosis_Homo sapiens_hsa041440.55692082
98Cyanoamino acid metabolism_Homo sapiens_hsa004600.55570154
99Drug metabolism - other enzymes_Homo sapiens_hsa009830.54424598
100Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.53918316
101Phenylalanine metabolism_Homo sapiens_hsa003600.53193750
102Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.51482961
103Hepatitis B_Homo sapiens_hsa051610.51396621
104Prolactin signaling pathway_Homo sapiens_hsa049170.50990705
105Bile secretion_Homo sapiens_hsa049760.50730568
106Prostate cancer_Homo sapiens_hsa052150.50547640
107Estrogen signaling pathway_Homo sapiens_hsa049150.49676750
108Pyruvate metabolism_Homo sapiens_hsa006200.49044545
109Salmonella infection_Homo sapiens_hsa051320.49018152
110Dilated cardiomyopathy_Homo sapiens_hsa054140.48430323
111Acute myeloid leukemia_Homo sapiens_hsa052210.48221662
112MicroRNAs in cancer_Homo sapiens_hsa052060.47975631
113PPAR signaling pathway_Homo sapiens_hsa033200.46931273
114Endometrial cancer_Homo sapiens_hsa052130.46610504
115Neurotrophin signaling pathway_Homo sapiens_hsa047220.45834313
116Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.45804147
117Pancreatic cancer_Homo sapiens_hsa052120.45522027
118GnRH signaling pathway_Homo sapiens_hsa049120.45142864
119Tyrosine metabolism_Homo sapiens_hsa003500.44594814
120Melanoma_Homo sapiens_hsa052180.44208010
121Vitamin digestion and absorption_Homo sapiens_hsa049770.43627021
122Pentose phosphate pathway_Homo sapiens_hsa000300.42396583
123Leukocyte transendothelial migration_Homo sapiens_hsa046700.42042280
124Butanoate metabolism_Homo sapiens_hsa006500.41969032
125Viral carcinogenesis_Homo sapiens_hsa052030.40071840
126Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.38661643
127Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.37847662
128Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.36756045

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