SLC39A8

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the SLC39 family of solute-carrier genes, which show structural characteristics of zinc transporters. The encoded protein is glycosylated and found in the plasma membrane and mitochondria, and functions in the cellular import of zinc at the onset of inflammation. It is also thought to be the primary transporter of the toxic cation cadmium, which is found in cigarette smoke. Multiple transcript variants encoding different isoforms have been found for this gene. Additional alternatively spliced transcript variants of this gene have been described, but their full-length nature is not known. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1surfactant homeostasis (GO:0043129)7.32917095
2chemical homeostasis within a tissue (GO:0048875)5.80956438
3regulation of vitamin D biosynthetic process (GO:0060556)5.60230206
4regulation of mononuclear cell migration (GO:0071675)4.86613118
5response to peptidoglycan (GO:0032494)4.83350136
6negative regulation of interleukin-12 production (GO:0032695)4.81627506
7cysteine metabolic process (GO:0006534)4.70159487
8regulation of vitamin metabolic process (GO:0030656)4.69919885
9alpha-linolenic acid metabolic process (GO:0036109)4.62288985
10lipopolysaccharide-mediated signaling pathway (GO:0031663)4.61464152
11positive regulation of gamma-delta T cell activation (GO:0046645)4.34644677
12cellular response to thyroid hormone stimulus (GO:0097067)4.28405984
13urate metabolic process (GO:0046415)4.22620769
14protoporphyrinogen IX metabolic process (GO:0046501)4.20944774
15positive regulation of interleukin-2 biosynthetic process (GO:0045086)4.09138410
16regulation of fever generation (GO:0031620)4.05084712
17positive regulation of chemokine biosynthetic process (GO:0045080)4.04814899
18erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)3.98761780
19L-phenylalanine catabolic process (GO:0006559)3.98761780
20protoporphyrinogen IX biosynthetic process (GO:0006782)3.96819142
21regulation of podosome assembly (GO:0071801)3.96082347
22lysine catabolic process (GO:0006554)3.95131246
23lysine metabolic process (GO:0006553)3.95131246
24transcytosis (GO:0045056)3.95011041
25positive regulation of heat generation (GO:0031652)3.91257189
26sulfur amino acid catabolic process (GO:0000098)3.86443485
27L-phenylalanine metabolic process (GO:0006558)3.85297143
28erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)3.85297143
29positive regulation of granulocyte macrophage colony-stimulating factor production (GO:0032725)3.82298867
30ethanol oxidation (GO:0006069)3.80624893
31complement activation, alternative pathway (GO:0006957)3.79575429
32pyrimidine-containing compound transmembrane transport (GO:0072531)3.77974587
33aromatic amino acid family catabolic process (GO:0009074)3.76290220
34drug transmembrane transport (GO:0006855)3.71908529
35negative regulation of myeloid cell apoptotic process (GO:0033033)3.71771818
36valine metabolic process (GO:0006573)3.68835392
37regulation of chemokine biosynthetic process (GO:0045073)3.66669086
38neutrophil activation involved in immune response (GO:0002283)3.65940579
39indole-containing compound catabolic process (GO:0042436)3.62697297
40indolalkylamine catabolic process (GO:0046218)3.62697297
41tryptophan catabolic process (GO:0006569)3.62697297
42regulation of endothelial cell differentiation (GO:0045601)3.61458516
43homocysteine metabolic process (GO:0050667)3.60158652
44sodium-independent organic anion transport (GO:0043252)3.59565504
45regulation of triglyceride catabolic process (GO:0010896)3.57559788
46cellular response to zinc ion (GO:0071294)3.56070101
47regulation of macrophage chemotaxis (GO:0010758)3.54185075
48regulation of gamma-delta T cell activation (GO:0046643)3.53463360
49peptidyl-glutamic acid carboxylation (GO:0017187)3.52597519
50protein carboxylation (GO:0018214)3.52597519
51regulation of protein activation cascade (GO:2000257)3.52244834
52monocyte chemotaxis (GO:0002548)3.50317750
53NIK/NF-kappaB signaling (GO:0038061)3.48432810
54tryptophan metabolic process (GO:0006568)3.47443976
55kynurenine metabolic process (GO:0070189)3.44894046
56regulation of complement activation (GO:0030449)3.43682566
57eosinophil chemotaxis (GO:0048245)3.43118527
58lymph vessel development (GO:0001945)3.42447940
59regulation of interleukin-2 biosynthetic process (GO:0045076)3.40455112
60positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)3.39905352
61triglyceride-rich lipoprotein particle remodeling (GO:0034370)3.39533487
62response to thyroid hormone (GO:0097066)3.39446565
63fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)3.39079153
64regulation of granulocyte macrophage colony-stimulating factor production (GO:0032645)3.38287960
65urea metabolic process (GO:0019627)3.36728675
66urea cycle (GO:0000050)3.36728675
67negative regulation of erythrocyte differentiation (GO:0045647)3.35266153
68negative regulation of fibrinolysis (GO:0051918)3.35054098
69high-density lipoprotein particle remodeling (GO:0034375)3.32714835
70macrophage activation involved in immune response (GO:0002281)3.32032391
71modulation by symbiont of host defense response (GO:0052031)3.29861899
72modulation by organism of immune response of other organism involved in symbiotic interaction (GO:003.29861899
73modulation by organism of defense response of other organism involved in symbiotic interaction (GO:03.29861899
74positive regulation by organism of defense response of other organism involved in symbiotic interact3.29861899
75modulation by symbiont of host immune response (GO:0052553)3.29861899
76positive regulation by symbiont of host defense response (GO:0052509)3.29861899
77heme transport (GO:0015886)3.29321772
78cellular extravasation (GO:0045123)3.26709308
79positive regulation of membrane protein ectodomain proteolysis (GO:0051044)3.25519912
80regulation of chronic inflammatory response (GO:0002676)3.21746157
81glyoxylate metabolic process (GO:0046487)3.20755741
82regulation of vasculogenesis (GO:2001212)3.20388192
83pattern specification involved in kidney development (GO:0061004)3.20367491
84positive regulation of heterotypic cell-cell adhesion (GO:0034116)3.17626781
85reverse cholesterol transport (GO:0043691)3.16146361
86cellular response to ethanol (GO:0071361)3.14731311
87immunoglobulin mediated immune response (GO:0016064)3.13504814
88positive regulation of NF-kappaB import into nucleus (GO:0042346)3.12771380
89response to phenylpropanoid (GO:0080184)3.12416875
90glycosphingolipid catabolic process (GO:0046479)3.11257691
91hormone catabolic process (GO:0042447)3.11075339
92amino-acid betaine metabolic process (GO:0006577)3.10889521
93T-helper 1 type immune response (GO:0042088)3.09812268
94acetyl-CoA metabolic process (GO:0006084)3.08658409
95peptide catabolic process (GO:0043171)3.08615852
96phosphate ion transmembrane transport (GO:0035435)3.08459507
97drug transport (GO:0015893)3.07709298
98nitrogen cycle metabolic process (GO:0071941)3.06098893
99regulation of vascular endothelial growth factor signaling pathway (GO:1900746)3.05660854
100eosinophil migration (GO:0072677)3.04792488
101response to nitrosative stress (GO:0051409)3.04474889
102bile acid biosynthetic process (GO:0006699)3.03483685
103serine family amino acid catabolic process (GO:0009071)3.03327411
104response to muramyl dipeptide (GO:0032495)3.02559992
105regulation of fibrinolysis (GO:0051917)3.01780760
106germinal center formation (GO:0002467)3.01433224
107hemidesmosome assembly (GO:0031581)3.01176960
108low-density lipoprotein particle clearance (GO:0034383)3.00378093
109positive regulation of lipoprotein lipase activity (GO:0051006)2.99518930
110positive regulation of triglyceride lipase activity (GO:0061365)2.99518930
111ethanol metabolic process (GO:0006067)2.99207831
112regulation of T-helper 1 cell differentiation (GO:0045625)2.98410577
113positive regulation of type 2 immune response (GO:0002830)2.97557893
114negative regulation of lipid storage (GO:0010888)2.96832889
115cellular biogenic amine catabolic process (GO:0042402)2.96379788
116amine catabolic process (GO:0009310)2.96379788
117response to protozoan (GO:0001562)2.95701216
118phospholipid homeostasis (GO:0055091)2.95370216
119plasma lipoprotein particle clearance (GO:0034381)2.93541397
120oligosaccharide catabolic process (GO:0009313)2.93143201
121regulation of interleukin-12 production (GO:0032655)2.93116136
122cellular response to lipopolysaccharide (GO:0071222)2.92969846
123linoleic acid metabolic process (GO:0043651)2.92933806
124drug catabolic process (GO:0042737)2.92508150
125regulation of cytokine secretion involved in immune response (GO:0002739)2.92328008
126negative regulation of cholesterol transport (GO:0032375)2.90038639
127negative regulation of sterol transport (GO:0032372)2.90038639
128positive regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043372)2.89995067
129negative regulation of leukocyte mediated cytotoxicity (GO:0001911)2.89368746
130negative regulation of cell killing (GO:0031342)2.89368746
131regulation of lymphocyte chemotaxis (GO:1901623)2.88026206
132negative regulation of nitric oxide biosynthetic process (GO:0045019)2.87758587
133very-low-density lipoprotein particle assembly (GO:0034379)2.87238936
134plasma lipoprotein particle assembly (GO:0034377)2.85449803
135positive regulation of p38MAPK cascade (GO:1900745)2.85319710
136T cell migration (GO:0072678)2.85297644
137regulation of sequestering of triglyceride (GO:0010889)2.85140636
138short-chain fatty acid metabolic process (GO:0046459)2.84498236
139cholesterol efflux (GO:0033344)2.84263635
140regulation of heat generation (GO:0031650)2.84072478
141granulocyte activation (GO:0036230)2.82806705
142triglyceride homeostasis (GO:0070328)2.81532596
143acylglycerol homeostasis (GO:0055090)2.81532596
144cellular response to molecule of bacterial origin (GO:0071219)2.80866687
145positive regulation of T-helper cell differentiation (GO:0045624)2.79853006
146macrophage differentiation (GO:0030225)2.79768615
147glycolipid catabolic process (GO:0019377)2.79545724
148lymphocyte chemotaxis (GO:0048247)2.78999951
149protein-lipid complex remodeling (GO:0034368)2.77924037
150macromolecular complex remodeling (GO:0034367)2.77924037
151plasma lipoprotein particle remodeling (GO:0034369)2.77924037
152cellular modified amino acid catabolic process (GO:0042219)2.77508045
153defense response to protozoan (GO:0042832)2.77244245
154L-ascorbic acid metabolic process (GO:0019852)2.77095832
155regulation of interferon-alpha production (GO:0032647)2.76552471
156thioester biosynthetic process (GO:0035384)2.74790489
157acyl-CoA biosynthetic process (GO:0071616)2.74790489
158negative regulation of interleukin-17 production (GO:0032700)2.73789616
159fatty-acyl-CoA biosynthetic process (GO:0046949)2.73114300
160bile acid and bile salt transport (GO:0015721)2.72899126
161cellular response to cadmium ion (GO:0071276)2.71918727
162regulation of immunoglobulin secretion (GO:0051023)2.71717756
163negative regulation of lipase activity (GO:0060192)2.71518801
164response to xenobiotic stimulus (GO:0009410)2.71482781
165decidualization (GO:0046697)2.71282978
166heme biosynthetic process (GO:0006783)2.71201697
167positive regulation of antigen processing and presentation (GO:0002579)2.70641909
168interferon-gamma-mediated signaling pathway (GO:0060333)2.70469745
169regulation of tumor necrosis factor biosynthetic process (GO:0042534)2.70365886
170positive regulation of syncytium formation by plasma membrane fusion (GO:0060143)2.69973213
171regulation of gamma-delta T cell differentiation (GO:0045586)2.69939796
172positive regulation of acute inflammatory response (GO:0002675)2.68869353
173regulation of membrane protein ectodomain proteolysis (GO:0051043)2.68139554
174response to mercury ion (GO:0046689)2.67116624
175regulation of T cell tolerance induction (GO:0002664)2.66743234
176regulation of dendritic cell antigen processing and presentation (GO:0002604)2.66584237
177positive regulation of CD4-positive, alpha-beta T cell activation (GO:2000516)2.66146981
178positive regulation of endothelial cell differentiation (GO:0045603)2.66099386
179acute-phase response (GO:0006953)2.65453278
180lipoprotein metabolic process (GO:0042157)2.65206961
181iron ion import (GO:0097286)2.65113644
182phosphate ion transport (GO:0006817)2.64981796
183regulation of cholesterol storage (GO:0010885)2.64358068
184serine family amino acid metabolic process (GO:0009069)2.63706865
185bile acid metabolic process (GO:0008206)2.63308875
186positive regulation of inflammatory response to antigenic stimulus (GO:0002863)2.62890887
187fatty acid oxidation (GO:0019395)2.60906898
188positive regulation of triglyceride metabolic process (GO:0090208)2.60379462
189regulation of interferon-beta biosynthetic process (GO:0045357)2.58795123
190regulation of antigen processing and presentation (GO:0002577)2.58474557
191positive regulation of interleukin-10 production (GO:0032733)2.58404773
192antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)2.58350061
193positive regulation of interferon-alpha production (GO:0032727)2.57291996
194myeloid cell activation involved in immune response (GO:0002275)2.57184608
195positive regulation of B cell differentiation (GO:0045579)2.56569761
196negative regulation of cytokine production involved in immune response (GO:0002719)2.56387139
197antigen processing and presentation of endogenous peptide antigen (GO:0002483)2.53627355
198positive regulation of interleukin-12 production (GO:0032735)2.53366834
199hydrogen peroxide biosynthetic process (GO:0050665)2.53159615

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1* ESR1_17901129_ChIP-ChIP_LIVER_Mouse7.13328938
2RXR_22158963_ChIP-Seq_LIVER_Mouse5.12092487
3PPARG_19300518_ChIP-PET_3T3-L1_Mouse4.94784429
4PPARA_22158963_ChIP-Seq_LIVER_Mouse4.57247540
5LXR_22158963_ChIP-Seq_LIVER_Mouse4.35078038
6GATA1_22025678_ChIP-Seq_K562_Human4.09249668
7IRF8_21731497_ChIP-ChIP_J774_Mouse3.98734233
8EGR1_23403033_ChIP-Seq_LIVER_Mouse3.89482414
9EGR1_19374776_ChIP-ChIP_THP-1_Human3.61541755
10TP63_17297297_ChIP-ChIP_HaCaT_Human3.58248311
11* STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse3.44370626
12TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse3.37171854
13IRF8_27001747_Chip-Seq_BMDM_Mouse3.33066999
14* MECOM_23826213_ChIP-Seq_KASUMI_Mouse3.02169081
15FOXO1_23066095_ChIP-Seq_LIVER_Mouse2.96513554
16CLOCK_20551151_ChIP-Seq_293T_Human2.93587742
17CEBPA_23403033_ChIP-Seq_LIVER_Mouse2.93390337
18* STAT4_19710469_ChIP-ChIP_TH1__Mouse2.69802613
19IRF8_22096565_ChIP-ChIP_GC-B_Mouse2.62447256
20TRIM28_21343339_ChIP-Seq_HEK293_Human2.61194150
21* ESR1_21235772_ChIP-Seq_MCF-7_Human2.55188652
22NR1I2_20693526_ChIP-Seq_LIVER_Mouse2.55135375
23STAT3_20064451_ChIP-Seq_CD4+T_Mouse2.52166394
24CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.51290601
25* STAT6_20620947_ChIP-Seq_CD4_POS_T_Human2.45921813
26SPI1_22096565_ChIP-ChIP_GC-B_Mouse2.42308843
27ESR2_21235772_ChIP-Seq_MCF-7_Human2.21921541
28STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse2.16165177
29RARG_19884340_ChIP-ChIP_MEFs_Mouse2.14386894
30FOXP3_17237761_ChIP-ChIP_TREG_Mouse2.13511100
31* SPI1_23547873_ChIP-Seq_NB4_Human2.07058277
32VDR_21846776_ChIP-Seq_THP-1_Human2.02822590
33HNF4A_19761587_ChIP-ChIP_CACO-2_Human2.02263269
34GATA4_25053715_ChIP-Seq_YYC3_Human2.02253035
35VDR_24763502_ChIP-Seq_THP-1_Human2.01787877
36CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.92353483
37RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.90565394
38PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.88859843
39SOX2_27498859_Chip-Seq_STOMACH_Mouse1.84954669
40MYB_26560356_Chip-Seq_TH2_Human1.84687608
41MYC_22102868_ChIP-Seq_BL_Human1.81932893
42SOX2_20726797_ChIP-Seq_SW620_Human1.79443048
43GATA1_19941826_ChIP-Seq_K562_Human1.78402644
44SPI1_23127762_ChIP-Seq_K562_Human1.73069764
45ZNF263_19887448_ChIP-Seq_K562_Human1.72810017
46FOXO3_23340844_ChIP-Seq_DLD1_Human1.71653298
47GATA2_21666600_ChIP-Seq_HMVEC_Human1.69812667
48TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.67904527
49* SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.67723774
50MAF_26560356_Chip-Seq_TH1_Human1.65885413
51PPAR_26484153_Chip-Seq_NCI-H1993_Human1.64591969
52SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.63385283
53* SALL4_18804426_ChIP-ChIP_XEN_Mouse1.60720568
54VDR_24787735_ChIP-Seq_THP-1_Human1.57652903
55RUNX_20019798_ChIP-Seq_JUKART_Human1.57080037
56RUNX1_22412390_ChIP-Seq_EML_Mouse1.56449239
57NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.55113055
58ESR1_20079471_ChIP-ChIP_T-47D_Human1.54508820
59IRF8_22096565_ChIP-ChIP_GC-B_Human1.53158462
60SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.52756655
61PU_27001747_Chip-Seq_BMDM_Mouse1.48125923
62CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.47264185
63PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.46019707
64RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.46005054
65NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.44511752
66FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.44189254
67MYB_26560356_Chip-Seq_TH1_Human1.43613292
68GATA2_22383799_ChIP-Seq_G1ME_Mouse1.43090570
69CDX2_20551321_ChIP-Seq_CACO-2_Human1.41783658
70KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.40482270
71AR_21915096_ChIP-Seq_LNCaP-1F5_Human1.38794997
72CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.37601438
73FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.35959779
74* GATA2_19941826_ChIP-Seq_K562_Human1.33269521
75SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.31761242
76SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.31761242
77ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.31662886
78MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.30575779
79GATA6_25053715_ChIP-Seq_YYC3_Human1.30519246
80CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.30227982
81FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.29148151
82E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.29120487
83LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.29014578
84UTX_26944678_Chip-Seq_JUKART_Human1.28863603
85SOX9_24532713_ChIP-Seq_HFSC_Mouse1.28792269
86FOXA2_19822575_ChIP-Seq_HepG2_Human1.27351803
87TCF7_22412390_ChIP-Seq_EML_Mouse1.26975015
88TFEB_21752829_ChIP-Seq_HELA_Human1.25972162
89TCF7L2_21901280_ChIP-Seq_H4IIE_Rat1.25743121
90Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.24174730
91HIF1A_21447827_ChIP-Seq_MCF-7_Human1.22859351
92FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human1.22733107
93LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.21920647
94SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.20581490
95ZNF217_24962896_ChIP-Seq_MCF-7_Human1.19693316
96SMAD_19615063_ChIP-ChIP_OVARY_Human1.19266547
97CDX2_19796622_ChIP-Seq_MESCs_Mouse1.18924345
98PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.18326674
99* TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.17611580
100TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.17221340
101E2F7_22180533_ChIP-Seq_HELA_Human1.17208088
102TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.14602481
103CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse1.13756677
104GATA3_24758297_ChIP-Seq_MCF-7_Human1.11962118
105FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human1.11076228
106P63_26484246_Chip-Seq_KERATINOCYTES_Human1.10876991
107PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse1.10553303
108KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.09755887
109ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.09628192
110GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.08002881
111RACK7_27058665_Chip-Seq_MCF-7_Human1.07666909
112AR_21909140_ChIP-Seq_LNCAP_Human1.07235420
113BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.06506316
114NCOR1_26117541_ChIP-Seq_K562_Human1.06035287
115GATA3_27048872_Chip-Seq_THYMUS_Human1.05991017
116SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.05250277
117* GATA1_19941827_ChIP-Seq_MEL_Mouse1.04954001
118ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.04716139
119NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.03321294
120STAT3_1855785_ChIP-Seq_MESCs_Mouse1.01446377
121* KDM2B_26808549_Chip-Seq_SUP-B15_Human1.00046212
122PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse0.99198369
123MAF_26560356_Chip-Seq_TH2_Human0.98756285
124* EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse0.98062562
125KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human0.97643914
126ERG_20887958_ChIP-Seq_HPC-7_Mouse0.96413519
127KLF1_20508144_ChIP-Seq_FETAL-LIVER-ERYTHROID_Mouse0.95927416
128ELK3_25401928_ChIP-Seq_HUVEC_Human0.95777451
129* TBX20_22328084_ChIP-Seq_HEART_Mouse0.95751508
130* TBX20_22080862_ChIP-Seq_HEART_Mouse0.95751508
131CJUN_26792858_Chip-Seq_BT549_Human0.95742041
132SCL_19346495_ChIP-Seq_HPC-7_Human0.95489393
133IRF1_21803131_ChIP-Seq_MONOCYTES_Human0.94969152
134CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse0.94002206
135ESR1_15608294_ChIP-ChIP_MCF-7_Human0.93224492
136THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse0.92211286
137GATA3_26560356_Chip-Seq_TH2_Human0.92102286
138GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.91989407
139BP1_19119308_ChIP-ChIP_Hs578T_Human0.90825095
140RUNX1_27514584_Chip-Seq_MCF-7_Human0.90409424
141HNF4A_19822575_ChIP-Seq_HepG2_Human0.90144326
142ESR1_22446102_ChIP-Seq_UTERUS_Mouse0.89518299
143FOXM1_26456572_ChIP-Seq_MCF-7_Human0.86917084
144STAT6_21828071_ChIP-Seq_BEAS2B_Human0.86070159
145LXR_22292898_ChIP-Seq_THP-1_Human0.85837636
146KDM2B_26808549_Chip-Seq_DND41_Human0.85139907
147NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse0.82872046
148JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.82156197
149TP63_23658742_ChIP-Seq_EP156T_Human0.80954137
150CHD7_19251738_ChIP-ChIP_MESCs_Mouse0.80882033
151FOXA1_25552417_ChIP-Seq_VCAP_Human0.80363870
152* MYB_21317192_ChIP-Seq_ERMYB_Mouse0.80039835
153TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat0.79818898
154HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse0.79271577
155ATF3_27146783_Chip-Seq_COLON_Human0.78935398
156BRD4_27068464_Chip-Seq_AML-cells_Mouse0.78288154
157JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.78150412
158* GATA1_22383799_ChIP-Seq_G1ME_Mouse0.76983478
159KDM2B_26808549_Chip-Seq_HPB-ALL_Human0.76602706
160NRF2_20460467_ChIP-Seq_MEFs_Mouse0.76164427
161NFE2L2_20460467_ChIP-Seq_MEFs_Mouse0.76164427
162NFIB_24661679_ChIP-Seq_LUNG_Mouse0.71761782
163AHR_22903824_ChIP-Seq_MCF-7_Human0.70626200
164SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse0.70612610
165EP300_21415370_ChIP-Seq_HL-1_Mouse0.70260070

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002139_abnormal_hepatobiliary_system4.60354396
2MP0005360_urolithiasis4.36701795
3MP0005085_abnormal_gallbladder_physiolo3.85720941
4MP0005083_abnormal_biliary_tract3.56140749
5MP0009785_altered_susceptibility_to3.33194465
6MP0004782_abnormal_surfactant_physiolog3.27433524
7MP0004147_increased_porphyrin_level3.21158119
8MP0002148_abnormal_hypersensitivity_rea3.19114222
9MP0005365_abnormal_bile_salt3.16631255
10MP0001881_abnormal_mammary_gland2.85325987
11MP0008875_abnormal_xenobiotic_pharmacok2.84285435
12MP0001835_abnormal_antigen_presentation2.78304124
13MP0010368_abnormal_lymphatic_system2.73595249
14MP0010234_abnormal_vibrissa_follicle2.72647949
15MP0006082_CNS_inflammation2.69934248
16MP0005000_abnormal_immune_tolerance2.64672345
17MP0001790_abnormal_immune_system2.55025097
18MP0005387_immune_system_phenotype2.55025097
19MP0002419_abnormal_innate_immunity2.51352578
20MP0002138_abnormal_hepatobiliary_system2.49212222
21MP0009278_abnormal_bone_marrow2.44912939
22MP0004019_abnormal_vitamin_homeostasis2.44767761
23MP0005025_abnormal_response_to2.42311624
24MP0005671_abnormal_response_to2.36585890
25MP0001879_abnormal_lymphatic_vessel2.32817559
26MP0003656_abnormal_erythrocyte_physiolo2.29386166
27MP0001666_abnormal_nutrient_absorption2.28213297
28MP0006054_spinal_hemorrhage2.21687881
29MP0005397_hematopoietic_system_phenotyp2.20970623
30MP0001545_abnormal_hematopoietic_system2.20970623
31MP0010329_abnormal_lipoprotein_level2.20459623
32MP0001853_heart_inflammation2.12308971
33MP0002452_abnormal_antigen_presenting2.10944450
34MP0003191_abnormal_cellular_cholesterol2.10152207
35MP0000685_abnormal_immune_system2.07188421
36MP0001958_emphysema2.06992652
37MP0002723_abnormal_immune_serum2.03265180
38MP0003300_gastrointestinal_ulcer2.03115593
39MP0001800_abnormal_humoral_immune1.99300784
40MP0003075_altered_response_to1.98147354
41MP0001533_abnormal_skeleton_physiology1.96658365
42MP0002098_abnormal_vibrissa_morphology1.91403539
43MP0000604_amyloidosis1.87400911
44MP0002405_respiratory_system_inflammati1.85546192
45MP0003252_abnormal_bile_duct1.80553920
46MP0005332_abnormal_amino_acid1.79850736
47MP0002254_reproductive_system_inflammat1.79314617
48MP0002998_abnormal_bone_remodeling1.77424691
49MP0002796_impaired_skin_barrier1.76513516
50MP0002420_abnormal_adaptive_immunity1.75657723
51MP0001819_abnormal_immune_cell1.75604070
52MP0003705_abnormal_hypodermis_morpholog1.75126959
53MP0004272_abnormal_basement_membrane1.74742630
54MP0001845_abnormal_inflammatory_respons1.71888497
55MP0003806_abnormal_nucleotide_metabolis1.65480958
56MP0003724_increased_susceptibility_to1.62120714
57MP0005451_abnormal_body_composition1.60083509
58MP0009643_abnormal_urine_homeostasis1.57777030
59MP0005167_abnormal_blood-brain_barrier1.57403145
60MP0009333_abnormal_splenocyte_physiolog1.52381244
61MP0005636_abnormal_mineral_homeostasis1.51664611
62MP0004264_abnormal_extraembryonic_tissu1.51413390
63MP0004510_myositis1.46540999
64MP0003448_altered_tumor_morphology1.45931901
65MP0003172_abnormal_lysosome_physiology1.45713272
66MP0002877_abnormal_melanocyte_morpholog1.41848943
67MP0003763_abnormal_thymus_physiology1.41408319
68MP0000609_abnormal_liver_physiology1.39764657
69MP0002118_abnormal_lipid_homeostasis1.39132908
70MP0008004_abnormal_stomach_pH1.38416569
71MP0005310_abnormal_salivary_gland1.35420967
72MP0004808_abnormal_hematopoietic_stem1.34636947
73MP0010678_abnormal_skin_adnexa1.33838845
74MP0000716_abnormal_immune_system1.33382048
75MP0000858_altered_metastatic_potential1.32073853
76MP0005501_abnormal_skin_physiology1.26036955
77MP0002398_abnormal_bone_marrow1.24429490
78MP0005408_hypopigmentation1.22963340
79MP0009840_abnormal_foam_cell1.21365587
80MP0009764_decreased_sensitivity_to1.20732565
81MP0005319_abnormal_enzyme/_coenzyme1.17269192
82MP0005647_abnormal_sex_gland1.17155085
83MP0002132_abnormal_respiratory_system1.13508757
84MP0002429_abnormal_blood_cell1.12298987
85MP0001756_abnormal_urination1.11204000
86MP0003186_abnormal_redox_activity1.10062840
87MP0000689_abnormal_spleen_morphology1.09216519
88MP0000627_abnormal_mammary_gland1.08619224
89MP0005275_abnormal_skin_tensile1.08064062
90MP0000383_abnormal_hair_follicle1.07836957
91MP0003690_abnormal_glial_cell1.07773069
92MP0002136_abnormal_kidney_physiology1.04214750
93MP0002722_abnormal_immune_system1.02261254
94MP0001873_stomach_inflammation1.01945479
95MP0009763_increased_sensitivity_to1.01554300
96MP0001765_abnormal_ion_homeostasis1.00770022
97MP0008995_early_reproductive_senescence0.99953222
98MP0003566_abnormal_cell_adhesion0.99950573
99MP0003828_pulmonary_edema0.97396269
100MP0000377_abnormal_hair_follicle0.97288899
101MP0000566_synostosis0.95519315
102MP0002295_abnormal_pulmonary_circulatio0.93534529
103MP0005164_abnormal_response_to0.92797543
104MP0001764_abnormal_homeostasis0.90444689
105MP0003453_abnormal_keratinocyte_physiol0.89457504
106MP0003795_abnormal_bone_structure0.89285114
107MP0009765_abnormal_xenobiotic_induced0.89155025
108MP0005584_abnormal_enzyme/coenzyme_acti0.86733271
109MP0001216_abnormal_epidermal_layer0.85602830
110MP0003329_amyloid_beta_deposits0.85177251
111MP0002006_tumorigenesis0.84280495
112MP0005390_skeleton_phenotype0.83936885
113MP0003091_abnormal_cell_migration0.81649132
114MP0001542_abnormal_bone_strength0.80889530
115MP0005058_abnormal_lysosome_morphology0.80397257
116MP0000579_abnormal_nail_morphology0.79326890
117MP0005084_abnormal_gallbladder_morpholo0.77883459
118MP0002060_abnormal_skin_morphology0.77474542
119MP0002166_altered_tumor_susceptibility0.77460900
120MP0003868_abnormal_feces_composition0.77417452
121MP0000598_abnormal_liver_morphology0.77168801
122MP0005076_abnormal_cell_differentiation0.77086534
123MP0009384_cardiac_valve_regurgitation0.76456405
124MP0010307_abnormal_tumor_latency0.75386675
125MP0004947_skin_inflammation0.75375381
126MP0005023_abnormal_wound_healing0.74910312
127MP0000465_gastrointestinal_hemorrhage0.73912662
128MP0001851_eye_inflammation0.73547668
129MP0000537_abnormal_urethra_morphology0.73040383
130MP0002133_abnormal_respiratory_system0.72190161
131MP0005388_respiratory_system_phenotype0.72190161
132MP0004883_abnormal_blood_vessel0.71880181
133MP0008469_abnormal_protein_level0.71670795
134MP0004130_abnormal_muscle_cell0.71545768
135MP0002332_abnormal_exercise_endurance0.71425995
136MP0003011_delayed_dark_adaptation0.71375266
137MP0003303_peritoneal_inflammation0.70746775
138MP0003638_abnormal_response/metabolism_0.70365783
139MP0009931_abnormal_skin_appearance0.69536337
140MP0000249_abnormal_blood_vessel0.68934711
141MP0005220_abnormal_exocrine_pancreas0.68739012
142MP0000767_abnormal_smooth_muscle0.67447956
143MP0005166_decreased_susceptibility_to0.67259766
144MP0001727_abnormal_embryo_implantation0.65614823
145MP0002933_joint_inflammation0.65492435
146MP0005464_abnormal_platelet_physiology0.65177414
147MP0008260_abnormal_autophagy0.64954720
148MP0008438_abnormal_cutaneous_collagen0.64564571
149MP0002135_abnormal_kidney_morphology0.64273635
150MP0000647_abnormal_sebaceous_gland0.63653845
151MP0002837_dystrophic_cardiac_calcinosis0.63384677
152MP0000920_abnormal_myelination0.62924040
153MP0005670_abnormal_white_adipose0.62853666
154MP0005165_increased_susceptibility_to0.62333717
155MP0010155_abnormal_intestine_physiology0.61373080
156MP0003195_calcinosis0.60904890
157MP0003436_decreased_susceptibility_to0.60790067
158MP0009053_abnormal_anal_canal0.60291202
159MP0010352_gastrointestinal_tract_polyps0.59881043
160MP0000343_altered_response_to0.59822642
161MP0000703_abnormal_thymus_morphology0.59248061
162MP0010771_integument_phenotype0.59215867
163MP0003183_abnormal_peptide_metabolism0.57288648
164MP0008874_decreased_physiological_sensi0.56959740

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of liposaccharide metabolism (HP:0010968)5.96271314
2Abnormality of glycosphingolipid metabolism (HP:0004343)5.96271314
3Abnormality of glycolipid metabolism (HP:0010969)5.96271314
4Abnormality of macrophages (HP:0004311)4.81178969
5Eczematoid dermatitis (HP:0000976)4.76621178
6Deep venous thrombosis (HP:0002625)4.67257713
7Interstitial pulmonary disease (HP:0006530)4.53906971
8Recurrent abscess formation (HP:0002722)4.51816735
9Recurrent bacterial skin infections (HP:0005406)4.49032829
10Onycholysis (HP:0001806)4.35312440
11Gout (HP:0001997)4.22535043
12Polycythemia (HP:0001901)4.04917626
13Intrahepatic cholestasis (HP:0001406)3.97845100
14Complement deficiency (HP:0004431)3.84004355
15Mediastinal lymphadenopathy (HP:0100721)3.81620320
16Abnormality of purine metabolism (HP:0004352)3.81337064
17Increased cerebral lipofuscin (HP:0011813)3.79114899
18Abnormality of the heme biosynthetic pathway (HP:0010472)3.65738452
19Hyperactive renin-angiotensin system (HP:0000841)3.63137075
20Stomatitis (HP:0010280)3.57609443
21Autoimmune thrombocytopenia (HP:0001973)3.56760643
22Dysostosis multiplex (HP:0000943)3.56614634
23Abnormality of monocarboxylic acid metabolism (HP:0010996)3.56454066
24Tubulointerstitial fibrosis (HP:0005576)3.53503842
25Recurrent gram-negative bacterial infections (HP:0005420)3.49909711
26Loss of speech (HP:0002371)3.48433324
27Esophageal varix (HP:0002040)3.47638053
28Increased serum ferritin (HP:0003281)3.44653341
29Xanthomatosis (HP:0000991)3.43858641
30Increased neuronal autofluorescent lipopigment (HP:0002074)3.17466043
31Hepatocellular carcinoma (HP:0001402)3.16585401
32Abnormality of aromatic amino acid family metabolism (HP:0004338)3.15670253
33Abnormality of glutamine family amino acid metabolism (HP:0010902)3.11305826
34Vascular calcification (HP:0004934)3.10475874
35Poikilocytosis (HP:0004447)3.09996538
36Hyperglycinuria (HP:0003108)3.06813986
37Abnormality of nucleobase metabolism (HP:0010932)3.02729027
38T lymphocytopenia (HP:0005403)3.00596335
39Disinhibition (HP:0000734)2.97754645
40Recurrent viral infections (HP:0004429)2.97715582
41Prolonged partial thromboplastin time (HP:0003645)2.95337363
42Glomerulonephritis (HP:0000099)2.94383726
43Neurofibrillary tangles (HP:0002185)2.92668246
44Recurrent skin infections (HP:0001581)2.91229798
45Recurrent fungal infections (HP:0002841)2.88093381
46Hematochezia (HP:0002573)2.85665510
47Abnormality of the common coagulation pathway (HP:0010990)2.84549665
48Acanthocytosis (HP:0001927)2.83648925
49Joint hemorrhage (HP:0005261)2.82921323
50Hypoglycemic coma (HP:0001325)2.82320089
51Abnormality of the intrinsic pathway (HP:0010989)2.82290733
52Cardiovascular calcification (HP:0011915)2.81443788
53Orchitis (HP:0100796)2.78943273
54Abnormality of complement system (HP:0005339)2.78126576
55Myositis (HP:0100614)2.77577034
56Hyperuricemia (HP:0002149)2.74562163
57Increased purine levels (HP:0004368)2.74562163
58Epidermoid cyst (HP:0200040)2.73218310
59Abnormality of T cell number (HP:0011839)2.72866794
60Abnormality of mucopolysaccharide metabolism (HP:0011020)2.70280856
61Abnormality of polysaccharide metabolism (HP:0011012)2.70280856
62Abnormality of glycosaminoglycan metabolism (HP:0004371)2.70280856
63Hypobetalipoproteinemia (HP:0003563)2.69841694
64Hyperglycinemia (HP:0002154)2.69095057
65Abnormality of sulfur amino acid metabolism (HP:0004339)2.68810344
66Obstructive lung disease (HP:0006536)2.68466431
67Chronic obstructive pulmonary disease (HP:0006510)2.68466431
68Fat malabsorption (HP:0002630)2.65088115
69Abnormality of serine family amino acid metabolism (HP:0010894)2.63636957
70Abnormality of glycine metabolism (HP:0010895)2.63636957
71Mucopolysacchariduria (HP:0008155)2.61950432
72Urinary glycosaminoglycan excretion (HP:0003541)2.61950432
73Hyperbilirubinemia (HP:0002904)2.60043144
74Hyperlipoproteinemia (HP:0010980)2.59910791
75Malnutrition (HP:0004395)2.59208507
76Increased IgM level (HP:0003496)2.57619509
77Retrobulbar optic neuritis (HP:0100654)2.57236170
78Optic neuritis (HP:0100653)2.57236170
79Metaphyseal irregularity (HP:0003025)2.56776685
80Renal salt wasting (HP:0000127)2.55565082
81Nephritis (HP:0000123)2.55398260
82Mutism (HP:0002300)2.54688651
83Nausea (HP:0002018)2.54364551
84Aortic aneurysm (HP:0004942)2.54108058
85Autoimmune hemolytic anemia (HP:0001890)2.53198537
86Reticulocytosis (HP:0001923)2.52092394
87Thoracic kyphosis (HP:0002942)2.49909799
88Gingivitis (HP:0000230)2.48545940
89Amelogenesis imperfecta (HP:0000705)2.47720803
90Abnormality of transition element cation homeostasis (HP:0011030)2.46671721
91Ketosis (HP:0001946)2.41531010
92Petechiae (HP:0000967)2.39796756
93Abnormality of chloride homeostasis (HP:0011422)2.38730762
94Right ventricular cardiomyopathy (HP:0011663)2.36244960
95Hyperammonemia (HP:0001987)2.36127773
96Hepatosplenomegaly (HP:0001433)2.34749696
97Tachypnea (HP:0002789)2.34531172
98Vasculitis (HP:0002633)2.33703983
99Respiratory distress (HP:0002098)2.32683282
100Hypochromic microcytic anemia (HP:0004840)2.32183710
101Woolly hair (HP:0002224)2.30204268
102Hemorrhage of the eye (HP:0011885)2.29084839
103Spontaneous hematomas (HP:0007420)2.28841993
104Hemoptysis (HP:0002105)2.28149547
105Hypolipoproteinemia (HP:0010981)2.27322422
106Potter facies (HP:0002009)2.26199366
107Facial shape deformation (HP:0011334)2.26199366
108Spastic diplegia (HP:0001264)2.25156308
109Abnormality of aspartate family amino acid metabolism (HP:0010899)2.24873376
110Pulmonary infiltrates (HP:0002113)2.23793761
111Hypergammaglobulinemia (HP:0010702)2.23444496
112Myocardial infarction (HP:0001658)2.23124422
113Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)2.22724018
114Amyloidosis (HP:0011034)2.22086247
115Elevated erythrocyte sedimentation rate (HP:0003565)2.22035161
116Abnormality of the level of lipoprotein cholesterol (HP:0010979)2.21213720
117Hypoalphalipoproteinemia (HP:0003233)2.20018244
118Abnormality of the nasal mucosa (HP:0000433)2.19924268
119Cerebral inclusion bodies (HP:0100314)2.19261930
120Combined immunodeficiency (HP:0005387)2.16617424
121Abnormality of renal excretion (HP:0011036)2.16354159
122Bone pain (HP:0002653)2.15958619
123Ileus (HP:0002595)2.15835205
124Steatorrhea (HP:0002570)2.14952059
125Chronic mucocutaneous candidiasis (HP:0002728)2.14620577
126Recurrent cutaneous fungal infections (HP:0011370)2.14620577
127Premature loss of primary teeth (HP:0006323)2.14365174
128Hydroxyprolinuria (HP:0003080)2.14122578
129Abnormality of proline metabolism (HP:0010907)2.14122578
130Cellulitis (HP:0100658)2.12850594
131Tubulointerstitial abnormality (HP:0001969)2.11954082
132Cholelithiasis (HP:0001081)2.11613813
133Microcytic anemia (HP:0001935)2.11048198
134Tetraparesis (HP:0002273)2.09758478
135Chronic bronchitis (HP:0004469)2.07572126
136Abnormality of iron homeostasis (HP:0011031)2.07002474
137Hypercholesterolemia (HP:0003124)2.06198769
138Meningitis (HP:0001287)2.05121775
139Progressive neurologic deterioration (HP:0002344)2.04148938
140Purpura (HP:0000979)2.04033109
141Osteomyelitis (HP:0002754)2.03979116
142Abnormality of the prostate (HP:0008775)2.03855126
143Polyneuropathy (HP:0001271)2.03841765
144Metabolic acidosis (HP:0001942)2.02747628
145Glomerulosclerosis (HP:0000096)2.02527825
146Leukocytosis (HP:0001974)2.02172243
147Tubulointerstitial nephritis (HP:0001970)2.01338284
148Osteolytic defects of the hand bones (HP:0009699)2.01176885
149Osteolytic defects of the phalanges of the hand (HP:0009771)2.01176885
150Diminished motivation (HP:0000745)1.99966731
151Rickets (HP:0002748)1.99940961
152Conjunctival telangiectasia (HP:0000524)1.99558704
153Nonimmune hydrops fetalis (HP:0001790)1.99157051
154Abnormality of T cells (HP:0002843)1.99017374
155Urticaria (HP:0001025)1.97950954
156Keratoconjunctivitis sicca (HP:0001097)1.97437696
157Abnormality of the vasculature of the conjunctiva (HP:0008054)1.97055775
158Systemic lupus erythematosus (HP:0002725)1.96600189
159Ketoacidosis (HP:0001993)1.96500525
160Aortic dissection (HP:0002647)1.96236602
161Widely patent fontanelles and sutures (HP:0004492)1.95698189
162Milia (HP:0001056)1.95375279
163Colitis (HP:0002583)1.95030012
164Joint swelling (HP:0001386)1.94777361
165Prostate neoplasm (HP:0100787)1.94411760
166Vacuolated lymphocytes (HP:0001922)1.93877718
167Abnormality of fatty-acid metabolism (HP:0004359)1.93820971
168Plantar hyperkeratosis (HP:0007556)1.93517455
169Gastrointestinal infarctions (HP:0005244)1.93355449
170Abnormal gallbladder morphology (HP:0012437)1.93100100
171Congenital, generalized hypertrichosis (HP:0004540)1.92487698
172Hypoglycemic seizures (HP:0002173)1.90893873
173Pili torti (HP:0003777)1.90650576
174Personality changes (HP:0000751)1.90370471
175Apathy (HP:0000741)1.90321074
176Abnormal cartilage morphology (HP:0002763)1.90190940
177Abnormality of the lumbar spine (HP:0100712)1.88295663
178Abnormality of B cell number (HP:0010975)1.87838375
179Nuclear cataract (HP:0100018)1.87721150
180Neuronal loss in central nervous system (HP:0002529)1.87301149
181Recurrent bronchitis (HP:0002837)1.86389818
182Keratoconjunctivitis (HP:0001096)1.86175476
183Amaurosis fugax (HP:0100576)1.85745545
184Pustule (HP:0200039)1.85348661
185Abnormality of the periventricular white matter (HP:0002518)1.84731735
186Progressive visual loss (HP:0000529)1.84411136

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TIE14.30494922
2KDR3.75372153
3TGFBR23.49969060
4ERN13.22393412
5SIK13.03136205
6MATK2.91496278
7LATS12.57527111
8BCKDK2.47610786
9TXK2.43123295
10MST42.39892480
11PRPF4B2.37762585
12FRK2.31333273
13GRK72.28640028
14TAOK22.15832901
15IKBKB2.12839155
16DDR22.12383536
17RIPK42.11847470
18LRRK22.07900573
19BLK2.04461688
20EEF2K2.03656389
21MAP4K12.01082127
22PKN22.00438372
23MAP3K31.90853317
24FGFR41.90221007
25MYLK1.86461690
26MAP3K131.84563367
27PTK61.84050194
28TRIB31.75866813
29EPHB21.75742664
30IRAK41.73607482
31TAOK31.73024290
32MAPKAPK31.72142558
33STK101.71246963
34RIPK11.68983179
35MST1R1.67126451
36GRK11.66752595
37PIM21.58412096
38EPHA21.55623597
39CAMK1D1.55028294
40NUAK11.47957020
41NEK91.43653814
42FGR1.43358698
43ACVR1B1.41523206
44FGFR21.40317022
45BMPR21.37544986
46ZAP701.33610454
47PDK21.27368289
48TGFBR11.21930791
49FER1.19689653
50HIPK21.18609772
51CHUK1.13831264
52TYK21.07757676
53MAP2K31.07648425
54CDK61.07554500
55PIK3CG1.07134883
56CDC42BPA1.06186650
57EPHB11.05484735
58LYN1.03782083
59PDK31.01396404
60PDK41.01396404
61INSRR1.00039192
62STK30.98161438
63MOS0.93976440
64CSF1R0.93374984
65CAMK1G0.92942408
66MAP3K10.92644934
67KIT0.92550121
68PRKAA20.92357496
69TBK10.92083473
70STK38L0.91500301
71JAK20.89173905
72SYK0.87782199
73PDGFRB0.87255227
74STK240.83407689
75WNK40.83255137
76IRAK10.82991493
77MAP3K20.82755724
78PAK40.81916329
79ADRBK20.80594808
80TRPM70.80257926
81MAP2K20.79716744
82STK390.78277801
83CLK10.77096005
84TAOK10.76613487
85SMG10.75943197
86JAK30.74474134
87RPS6KB20.73357321
88LCK0.73154401
89PIM10.72870205
90EPHA30.72558582
91GSK3A0.72456740
92BTK0.71652384
93MAPK110.69911880
94PRKG20.69399874
95PBK0.68412253
96LMTK20.67857331
97SCYL20.66363993
98MET0.64977212
99PTK20.64643859
100FLT30.64440010
101FGFR30.64154477
102DAPK20.62665475
103HCK0.62424282
104PIK3CA0.62263656
105JAK10.61468432
106TESK20.61244441
107IRAK20.60824568
108IRAK30.60665638
109MAP3K140.60449280
110EIF2AK30.59628631
111PDGFRA0.59512913
112RPS6KL10.58412141
113RPS6KC10.58412141
114MAPK150.57747204
115AKT30.57489982
116MAP3K70.57414422
117LATS20.54897913
118EGFR0.54300225
119NME20.52919853
120RPS6KA40.52630155
121CDK40.52429280
122DYRK1B0.52359323
123MAP3K50.52208227
124CSK0.51395346
125DAPK10.50120993
126PAK20.49768339
127ARAF0.48812497
128MAPK120.48090217
129IGF1R0.47443408
130FES0.47154366
131PTK2B0.46958522
132EIF2AK10.45033872
133MAP2K10.44808438
134DAPK30.44213544
135MAPK40.44031003
136OXSR10.43882922
137RAF10.42762580
138MARK30.42732071
139RPS6KA60.42249818
140ERBB20.42048153
141KSR20.41990358
142IKBKE0.40962300
143NLK0.40744083
144CAMKK20.40494438
145TEC0.39592255
146EIF2AK20.39506317
147ABL10.37873932
148MAP3K80.37706809
149TTN0.35950431
150ALK0.34533937
151BMX0.33595774
152ITK0.33309347
153RPS6KA20.32767710
154ABL20.32305736
155PDK10.31555781
156MAP3K110.31234140
157BRAF0.30803482
158PDPK10.30168445
159MAPK70.30019097

Predicted pathways (KEGG)

RankGene SetZ-score
1Caffeine metabolism_Homo sapiens_hsa002324.14292213
2Fatty acid biosynthesis_Homo sapiens_hsa000613.28484757
3Rheumatoid arthritis_Homo sapiens_hsa053232.96294439
4Primary bile acid biosynthesis_Homo sapiens_hsa001202.94974954
5Ascorbate and aldarate metabolism_Homo sapiens_hsa000532.82040410
6Toll-like receptor signaling pathway_Homo sapiens_hsa046202.73162291
7Leishmaniasis_Homo sapiens_hsa051402.54570836
8NF-kappa B signaling pathway_Homo sapiens_hsa040642.52812962
9NOD-like receptor signaling pathway_Homo sapiens_hsa046212.50832503
10Osteoclast differentiation_Homo sapiens_hsa043802.45065825
11Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010402.42485393
12Fatty acid degradation_Homo sapiens_hsa000712.38491640
13Nitrogen metabolism_Homo sapiens_hsa009102.33644385
14Allograft rejection_Homo sapiens_hsa053302.32429364
15Graft-versus-host disease_Homo sapiens_hsa053322.31277815
16TNF signaling pathway_Homo sapiens_hsa046682.30481265
17Complement and coagulation cascades_Homo sapiens_hsa046102.29737075
18Asthma_Homo sapiens_hsa053102.23952221
19Propanoate metabolism_Homo sapiens_hsa006402.23589156
20Tryptophan metabolism_Homo sapiens_hsa003802.22434328
21Arginine biosynthesis_Homo sapiens_hsa002202.16053995
22Inflammatory bowel disease (IBD)_Homo sapiens_hsa053212.14338187
23Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.11807306
24Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006302.08277720
25PPAR signaling pathway_Homo sapiens_hsa033202.07835028
26Butirosin and neomycin biosynthesis_Homo sapiens_hsa005242.04299079
27Pentose and glucuronate interconversions_Homo sapiens_hsa000402.02956414
28Tuberculosis_Homo sapiens_hsa051521.97137401
29Fatty acid metabolism_Homo sapiens_hsa012121.90407627
30Intestinal immune network for IgA production_Homo sapiens_hsa046721.89035356
31Peroxisome_Homo sapiens_hsa041461.88302029
32RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.86848367
33Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.86578167
34Salmonella infection_Homo sapiens_hsa051321.83592771
35beta-Alanine metabolism_Homo sapiens_hsa004101.81573620
36Hematopoietic cell lineage_Homo sapiens_hsa046401.78496433
37Autoimmune thyroid disease_Homo sapiens_hsa053201.77253205
38Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.77064822
39Vitamin digestion and absorption_Homo sapiens_hsa049771.76281058
40Selenocompound metabolism_Homo sapiens_hsa004501.76151241
41Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.72419853
42Type I diabetes mellitus_Homo sapiens_hsa049401.72088382
43Antigen processing and presentation_Homo sapiens_hsa046121.66591027
44ABC transporters_Homo sapiens_hsa020101.65809081
45Histidine metabolism_Homo sapiens_hsa003401.61478720
46Pyruvate metabolism_Homo sapiens_hsa006201.60069087
47Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.59893178
48Chemical carcinogenesis_Homo sapiens_hsa052041.59263054
49Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.58291052
50Influenza A_Homo sapiens_hsa051641.57538730
51Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.57518411
52Bile secretion_Homo sapiens_hsa049761.55685632
53Staphylococcus aureus infection_Homo sapiens_hsa051501.53614466
54African trypanosomiasis_Homo sapiens_hsa051431.47258175
55Measles_Homo sapiens_hsa051621.45640904
56Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.44418939
57Phagosome_Homo sapiens_hsa041451.43317355
58Retinol metabolism_Homo sapiens_hsa008301.42824532
59Primary immunodeficiency_Homo sapiens_hsa053401.42562068
60Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.42011007
61Herpes simplex infection_Homo sapiens_hsa051681.41988392
62B cell receptor signaling pathway_Homo sapiens_hsa046621.39862366
63Fat digestion and absorption_Homo sapiens_hsa049751.38072363
64Sulfur metabolism_Homo sapiens_hsa009201.33529132
65Prion diseases_Homo sapiens_hsa050201.28952545
66Chemokine signaling pathway_Homo sapiens_hsa040621.25376231
67Steroid hormone biosynthesis_Homo sapiens_hsa001401.24792393
68Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.20648223
69Drug metabolism - other enzymes_Homo sapiens_hsa009831.18243770
70Shigellosis_Homo sapiens_hsa051311.17026933
71Hepatitis B_Homo sapiens_hsa051611.15285403
72Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051201.14738397
73Sulfur relay system_Homo sapiens_hsa041221.12354647
74Butanoate metabolism_Homo sapiens_hsa006501.10667773
75Jak-STAT signaling pathway_Homo sapiens_hsa046301.10572426
762-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.10538380
77Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.08855141
78Fatty acid elongation_Homo sapiens_hsa000621.08823447
79Mineral absorption_Homo sapiens_hsa049781.07986951
80Cyanoamino acid metabolism_Homo sapiens_hsa004601.05229436
81Acute myeloid leukemia_Homo sapiens_hsa052211.05225560
82Viral myocarditis_Homo sapiens_hsa054161.02572625
83Arginine and proline metabolism_Homo sapiens_hsa003301.01488982
84Apoptosis_Homo sapiens_hsa042100.97112813
85Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.96518104
86Glutathione metabolism_Homo sapiens_hsa004800.95173643
87Glycerolipid metabolism_Homo sapiens_hsa005610.93804540
88T cell receptor signaling pathway_Homo sapiens_hsa046600.91155883
89Phenylalanine metabolism_Homo sapiens_hsa003600.91012910
90Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.90271564
91Systemic lupus erythematosus_Homo sapiens_hsa053220.87796436
92Galactose metabolism_Homo sapiens_hsa000520.86514781
93Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.85608280
94Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.82737722
95Carbon metabolism_Homo sapiens_hsa012000.81232321
96ECM-receptor interaction_Homo sapiens_hsa045120.81097479
97Starch and sucrose metabolism_Homo sapiens_hsa005000.80924329
98Lysine degradation_Homo sapiens_hsa003100.80867247
99Folate biosynthesis_Homo sapiens_hsa007900.79135572
100Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.71345330
101Tyrosine metabolism_Homo sapiens_hsa003500.68856260
102Transcriptional misregulation in cancer_Homo sapiens_hsa052020.67346912
103Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.64741449
104Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.64377043
105Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.63456548
106Cysteine and methionine metabolism_Homo sapiens_hsa002700.63205155
107Vitamin B6 metabolism_Homo sapiens_hsa007500.62664231
108Epstein-Barr virus infection_Homo sapiens_hsa051690.62145942
109Small cell lung cancer_Homo sapiens_hsa052220.61380573
110Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.61306257
111Biosynthesis of amino acids_Homo sapiens_hsa012300.60907737
112Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.60061611
113Viral carcinogenesis_Homo sapiens_hsa052030.58150148
114Prolactin signaling pathway_Homo sapiens_hsa049170.57045643
115Renin-angiotensin system_Homo sapiens_hsa046140.56897298
116Protein digestion and absorption_Homo sapiens_hsa049740.56742146
117Adipocytokine signaling pathway_Homo sapiens_hsa049200.56720140
118Pentose phosphate pathway_Homo sapiens_hsa000300.55376851
119Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.55107392
120Chronic myeloid leukemia_Homo sapiens_hsa052200.54840667
121Steroid biosynthesis_Homo sapiens_hsa001000.54593329
122Pancreatic cancer_Homo sapiens_hsa052120.53771064
123Collecting duct acid secretion_Homo sapiens_hsa049660.53187998
124Sphingolipid metabolism_Homo sapiens_hsa006000.51265655
125Adherens junction_Homo sapiens_hsa045200.51044313
126Insulin resistance_Homo sapiens_hsa049310.50821570
127Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.49668743
128Hepatitis C_Homo sapiens_hsa051600.49399394
129Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.48878496
130Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.48643161
131VEGF signaling pathway_Homo sapiens_hsa043700.48375033
132Leukocyte transendothelial migration_Homo sapiens_hsa046700.47340557
133Lysosome_Homo sapiens_hsa041420.47073600
134Amoebiasis_Homo sapiens_hsa051460.46283094
135HTLV-I infection_Homo sapiens_hsa051660.45975168
136Maturity onset diabetes of the young_Homo sapiens_hsa049500.45675868
137Platelet activation_Homo sapiens_hsa046110.45045989
138Malaria_Homo sapiens_hsa051440.41228638
139Toxoplasmosis_Homo sapiens_hsa051450.39433803
140Sphingolipid signaling pathway_Homo sapiens_hsa040710.38839315
141Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.38549843
142Bladder cancer_Homo sapiens_hsa052190.38062917
143Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.37652078
144Focal adhesion_Homo sapiens_hsa045100.34725861
145Other glycan degradation_Homo sapiens_hsa005110.34365585
146Metabolic pathways_Homo sapiens_hsa011000.33160927
147Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.32815125
148AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.32651426
149HIF-1 signaling pathway_Homo sapiens_hsa040660.31294876
150Glycosaminoglycan degradation_Homo sapiens_hsa005310.30346823
151Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.28191370
152Neurotrophin signaling pathway_Homo sapiens_hsa047220.28146580
153Pertussis_Homo sapiens_hsa051330.27293643
154Tight junction_Homo sapiens_hsa045300.27081972
155N-Glycan biosynthesis_Homo sapiens_hsa005100.25383499
156Vibrio cholerae infection_Homo sapiens_hsa051100.25261707
157AMPK signaling pathway_Homo sapiens_hsa041520.24600002
158alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.23502375
159One carbon pool by folate_Homo sapiens_hsa006700.21271219
160Renal cell carcinoma_Homo sapiens_hsa052110.19511228
161Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.19408219
162Type II diabetes mellitus_Homo sapiens_hsa049300.18575458
163Fructose and mannose metabolism_Homo sapiens_hsa000510.17980671
164Non-small cell lung cancer_Homo sapiens_hsa052230.17211769
165Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.16913206
166Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.15415207
167Legionellosis_Homo sapiens_hsa051340.15091235
168Endocytosis_Homo sapiens_hsa041440.10478603
169Proteoglycans in cancer_Homo sapiens_hsa052050.09740426
170SNARE interactions in vesicular transport_Homo sapiens_hsa041300.08054119

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