SLC39A9

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)5.48584732
2L-phenylalanine catabolic process (GO:0006559)5.48584732
3alpha-linolenic acid metabolic process (GO:0036109)5.25218680
4erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)5.20662226
5L-phenylalanine metabolic process (GO:0006558)5.20662226
6COPI coating of Golgi vesicle (GO:0048205)4.93281143
7Golgi transport vesicle coating (GO:0048200)4.93281143
8triglyceride-rich lipoprotein particle remodeling (GO:0034370)4.82028579
9intestinal cholesterol absorption (GO:0030299)4.75143423
10aromatic amino acid family catabolic process (GO:0009074)4.67715879
11cysteine metabolic process (GO:0006534)4.59155520
12lactate metabolic process (GO:0006089)4.50667508
13sulfur amino acid catabolic process (GO:0000098)4.49519572
14lysine catabolic process (GO:0006554)4.34340692
15lysine metabolic process (GO:0006553)4.34340692
16kynurenine metabolic process (GO:0070189)4.28597114
17protein carboxylation (GO:0018214)4.22698744
18peptidyl-glutamic acid carboxylation (GO:0017187)4.22698744
19high-density lipoprotein particle remodeling (GO:0034375)4.21573516
20glyoxylate metabolic process (GO:0046487)4.15517572
21intestinal absorption (GO:0050892)4.15058401
22homocysteine metabolic process (GO:0050667)4.13549195
23tryptophan catabolic process (GO:0006569)4.09717224
24indole-containing compound catabolic process (GO:0042436)4.09717224
25indolalkylamine catabolic process (GO:0046218)4.09717224
26reverse cholesterol transport (GO:0043691)4.04592860
27bile acid biosynthetic process (GO:0006699)4.02311473
28regulation of cholesterol homeostasis (GO:2000188)4.01612103
29fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)4.01207453
30keratinocyte development (GO:0003334)3.99102141
31cellular ketone body metabolic process (GO:0046950)3.94801548
32urea metabolic process (GO:0019627)3.93864217
33urea cycle (GO:0000050)3.93864217
34mitotic sister chromatid cohesion (GO:0007064)3.90130541
35regulation of triglyceride catabolic process (GO:0010896)3.89849579
36negative regulation of cholesterol transport (GO:0032375)3.88925714
37negative regulation of sterol transport (GO:0032372)3.88925714
38tryptophan metabolic process (GO:0006568)3.85702811
39cellular modified amino acid catabolic process (GO:0042219)3.83919481
40bile acid and bile salt transport (GO:0015721)3.83229026
41negative regulation of fibrinolysis (GO:0051918)3.76221957
42regulation of hexokinase activity (GO:1903299)3.76127751
43regulation of glucokinase activity (GO:0033131)3.76127751
44bile acid metabolic process (GO:0008206)3.75394519
45COPII vesicle coating (GO:0048208)3.74113281
46amino-acid betaine metabolic process (GO:0006577)3.72629528
47protein-lipid complex remodeling (GO:0034368)3.67188597
48macromolecular complex remodeling (GO:0034367)3.67188597
49plasma lipoprotein particle remodeling (GO:0034369)3.67188597
50valine metabolic process (GO:0006573)3.65684735
51phospholipid efflux (GO:0033700)3.59810319
52maintenance of protein localization in endoplasmic reticulum (GO:0035437)3.57582660
53positive regulation of protein autophosphorylation (GO:0031954)3.56687992
54complement activation, alternative pathway (GO:0006957)3.56209938
55regulation of protein activation cascade (GO:2000257)3.54840981
56nitrogen cycle metabolic process (GO:0071941)3.54521771
57positive regulation of glycolytic process (GO:0045821)3.53155816
58histone H2A acetylation (GO:0043968)3.51221519
59cholesterol efflux (GO:0033344)3.49703106
60drug catabolic process (GO:0042737)3.48602077
61serine family amino acid catabolic process (GO:0009071)3.47113588
62acylglycerol homeostasis (GO:0055090)3.43400626
63triglyceride homeostasis (GO:0070328)3.43400626
64ketone body metabolic process (GO:1902224)3.42089350
65regulation of cholesterol esterification (GO:0010872)3.41801797
66plasma lipoprotein particle assembly (GO:0034377)3.40075709
67alpha-amino acid catabolic process (GO:1901606)3.39540539
68protein retention in ER lumen (GO:0006621)3.39200675
69drug transmembrane transport (GO:0006855)3.37835360
70DNA double-strand break processing (GO:0000729)3.35943180
71signal peptide processing (GO:0006465)3.35922186
72positive regulation of fatty acid beta-oxidation (GO:0032000)3.35888444
73regulation of fibrinolysis (GO:0051917)3.35139145
74regulation of complement activation (GO:0030449)3.34596934
75coenzyme catabolic process (GO:0009109)3.33056699
764-hydroxyproline metabolic process (GO:0019471)3.32705240
772-oxoglutarate metabolic process (GO:0006103)3.32384089
78cellular amino acid catabolic process (GO:0009063)3.28252705
79aromatic amino acid family metabolic process (GO:0009072)3.26400669
80glutamate metabolic process (GO:0006536)3.25974729
81short-chain fatty acid metabolic process (GO:0046459)3.24076492
82regulation of fatty acid beta-oxidation (GO:0031998)3.23534303
83ethanol oxidation (GO:0006069)3.22731816
84positive regulation of mitotic sister chromatid separation (GO:1901970)3.22653084
85positive regulation of mitotic metaphase/anaphase transition (GO:0045842)3.22653084
86positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)3.22653084
87lipoprotein metabolic process (GO:0042157)3.20892202
88dicarboxylic acid biosynthetic process (GO:0043650)3.20805779
89plasma lipoprotein particle clearance (GO:0034381)3.18453708
90protein-lipid complex assembly (GO:0065005)3.15385767
91positive regulation of lipid catabolic process (GO:0050996)3.15283761
92phospholipid homeostasis (GO:0055091)3.15209953
93regulation of cholesterol biosynthetic process (GO:0045540)3.13937211
94sterol homeostasis (GO:0055092)3.13021638
95cholesterol homeostasis (GO:0042632)3.12786861
96tyrosine metabolic process (GO:0006570)3.11591564
97positive regulation of triglyceride metabolic process (GO:0090208)3.10766736
98retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)3.07902918
99aspartate family amino acid catabolic process (GO:0009068)3.06452096
100fatty acid oxidation (GO:0019395)3.05520285
101fatty acid beta-oxidation (GO:0006635)3.05443914
102cellular glucuronidation (GO:0052695)3.03364980
103positive regulation of triglyceride lipase activity (GO:0061365)3.03197663
104positive regulation of lipoprotein lipase activity (GO:0051006)3.03197663
105regulation of cholesterol metabolic process (GO:0090181)3.03037319
106plasma lipoprotein particle organization (GO:0071827)3.02810110
107lipid oxidation (GO:0034440)2.99967263
108cholesterol transport (GO:0030301)2.99262839
109sterol transport (GO:0015918)2.99262839
110positive regulation of fatty acid biosynthetic process (GO:0045723)2.98908801
111inositol phosphate catabolic process (GO:0071545)2.96687361
112activation of signaling protein activity involved in unfolded protein response (GO:0006987)2.93358633
113UDP-N-acetylglucosamine metabolic process (GO:0006047)2.93096231
114positive regulation of glycoprotein biosynthetic process (GO:0010560)2.92801241
115benzene-containing compound metabolic process (GO:0042537)2.91628567
116resolution of meiotic recombination intermediates (GO:0000712)2.83449630
117regulation of protein glycosylation (GO:0060049)2.82407682
118regulation of type B pancreatic cell apoptotic process (GO:2000674)2.81881196
119* zinc ion transport (GO:0006829)2.79919003
120negative regulation of neurological system process (GO:0031645)2.78281550
121regulation of attachment of spindle microtubules to kinetochore (GO:0051988)2.76469647
122intraciliary transport (GO:0042073)2.76464617
123regulation of ER to Golgi vesicle-mediated transport (GO:0060628)2.74327477
124branched-chain amino acid catabolic process (GO:0009083)2.73278426
125prenylation (GO:0097354)2.73000553
126protein prenylation (GO:0018342)2.73000553
127proteasome assembly (GO:0043248)2.72853564
128positive regulation of glycoprotein metabolic process (GO:1903020)2.72531538
129heme transport (GO:0015886)2.71884221
130regulation of centriole replication (GO:0046599)2.71793632
131metaphase plate congression (GO:0051310)2.71044194
132peptidyl-cysteine modification (GO:0018198)2.69861186
133negative regulation of execution phase of apoptosis (GO:1900118)2.69266463
134sphingomyelin metabolic process (GO:0006684)2.65337500
135replication fork processing (GO:0031297)2.64426015
136regulation of DNA endoreduplication (GO:0032875)2.64380238
137regulation of Rac protein signal transduction (GO:0035020)2.63345186
138kinetochore organization (GO:0051383)2.63105828
139negative regulation of JUN kinase activity (GO:0043508)2.62640512
140prostate gland growth (GO:0060736)2.62088834
141polyol catabolic process (GO:0046174)2.58959649
142xenobiotic catabolic process (GO:0042178)2.58248205
143water-soluble vitamin biosynthetic process (GO:0042364)2.57523523
144protein K6-linked ubiquitination (GO:0085020)2.57356180
145respiratory chain complex IV assembly (GO:0008535)2.56804227
146cytochrome complex assembly (GO:0017004)2.53495493
147endocrine pancreas development (GO:0031018)2.51146448
148response to pheromone (GO:0019236)2.50701784
149non-recombinational repair (GO:0000726)2.50667938
150double-strand break repair via nonhomologous end joining (GO:0006303)2.50667938
151positive regulation of macroautophagy (GO:0016239)2.49140516
152synapsis (GO:0007129)2.48633431
153phosphorylated carbohydrate dephosphorylation (GO:0046838)2.47452368
154inositol phosphate dephosphorylation (GO:0046855)2.47452368
155kinetochore assembly (GO:0051382)2.45636538
156cullin deneddylation (GO:0010388)2.44351742
157intestinal epithelial cell development (GO:0060576)2.42838860
158regulation of keratinocyte proliferation (GO:0010837)2.42682813
159establishment of chromosome localization (GO:0051303)2.41335964
160regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway (GO:19022352.37728275
161attachment of spindle microtubules to kinetochore (GO:0008608)2.37300458
162positive regulation of actin filament depolymerization (GO:0030836)2.37226861
163ER overload response (GO:0006983)2.34605533
164protein heterotetramerization (GO:0051290)2.34109421
165negative regulation of tumor necrosis factor-mediated signaling pathway (GO:0010804)2.33837418
166negative regulation of dendrite development (GO:2000171)2.32605454
167female gonad development (GO:0008585)2.30968401
168platelet dense granule organization (GO:0060155)2.29420709
169lipid particle organization (GO:0034389)2.26819683
170positive regulation of response to nutrient levels (GO:0032109)2.25185336
171positive regulation of response to extracellular stimulus (GO:0032106)2.25185336
172limb bud formation (GO:0060174)2.24106801
173aldehyde catabolic process (GO:0046185)2.24092941
174negative regulation of DNA-dependent DNA replication (GO:2000104)2.24048405
175negative regulation of hormone biosynthetic process (GO:0032353)2.23645182
176dolichol-linked oligosaccharide biosynthetic process (GO:0006488)2.23312643
177dorsal/ventral axis specification (GO:0009950)2.19963619
178genitalia morphogenesis (GO:0035112)2.18300439
179spindle checkpoint (GO:0031577)2.16997000
180nucleotide transmembrane transport (GO:1901679)2.16881468
181mitotic metaphase plate congression (GO:0007080)2.15758576
182brain morphogenesis (GO:0048854)2.15472829
183intra-Golgi vesicle-mediated transport (GO:0006891)2.15319993
184DNA ligation (GO:0006266)2.15091313
185regulation of protein autophosphorylation (GO:0031952)2.14973501
186Leydig cell differentiation (GO:0033327)2.14376539
187negative regulation of dendrite morphogenesis (GO:0050774)2.13272360
188retinol metabolic process (GO:0042572)2.12851843
189histone exchange (GO:0043486)2.12721870
190response to X-ray (GO:0010165)2.12231430
191cholesterol biosynthetic process (GO:0006695)2.12057803
192transcytosis (GO:0045056)2.11130697
193sphingosine metabolic process (GO:0006670)2.09492281
194sphingoid metabolic process (GO:0046519)2.08745417
195recombinational repair (GO:0000725)2.08426251

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1ESR1_17901129_ChIP-ChIP_LIVER_Mouse8.71039581
2RXR_22158963_ChIP-Seq_LIVER_Mouse6.41492641
3PPARA_22158963_ChIP-Seq_LIVER_Mouse5.66755205
4LXR_22158963_ChIP-Seq_LIVER_Mouse5.29424727
5PPARG_19300518_ChIP-PET_3T3-L1_Mouse4.21837174
6FOXO1_23066095_ChIP-Seq_LIVER_Mouse3.84664973
7EGR1_23403033_ChIP-Seq_LIVER_Mouse3.78171826
8SALL1_21062744_ChIP-ChIP_HESCs_Human3.46855515
9NR1I2_20693526_ChIP-Seq_LIVER_Mouse3.44737423
10CEBPA_23403033_ChIP-Seq_LIVER_Mouse3.21324323
11GATA1_22025678_ChIP-Seq_K562_Human2.95492485
12* POU3F2_20337985_ChIP-ChIP_501MEL_Human2.80300364
13CLOCK_20551151_ChIP-Seq_293T_Human2.78689265
14CEBPD_23245923_ChIP-Seq_MEFs_Mouse2.64708116
15CEBPB_23403033_ChIP-Seq_LIVER_Mouse2.48717319
16ZFP57_27257070_Chip-Seq_ESCs_Mouse2.48470547
17* KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.39944272
18SOX2_27498859_Chip-Seq_STOMACH_Mouse2.23015028
19FUS_26573619_Chip-Seq_HEK293_Human2.20530504
20AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human2.17354521
21TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse2.16852090
22GBX2_23144817_ChIP-Seq_PC3_Human2.16191837
23ZNF274_21170338_ChIP-Seq_K562_Hela2.11698203
24* ELK1_19687146_ChIP-ChIP_HELA_Human2.11125257
25EWS_26573619_Chip-Seq_HEK293_Human1.99556917
26BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.97822244
27FOXA2_19822575_ChIP-Seq_HepG2_Human1.97339123
28HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.95454543
29GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.93554378
30P300_19829295_ChIP-Seq_ESCs_Human1.88790132
31STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.88083911
32TAF15_26573619_Chip-Seq_HEK293_Human1.87417568
33* GABP_17652178_ChIP-ChIP_JURKAT_Human1.87352248
34PIAS1_25552417_ChIP-Seq_VCAP_Human1.87276732
35AR_21909140_ChIP-Seq_LNCAP_Human1.86207310
36FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.84201460
37TP63_17297297_ChIP-ChIP_HaCaT_Human1.83431183
38E2F4_17652178_ChIP-ChIP_JURKAT_Human1.81892488
39TCF7L2_21901280_ChIP-Seq_H4IIE_Rat1.80485685
40VDR_22108803_ChIP-Seq_LS180_Human1.76062822
41FLI1_27457419_Chip-Seq_LIVER_Mouse1.72034955
42PADI4_21655091_ChIP-ChIP_MCF-7_Human1.67477255
43FOXM1_23109430_ChIP-Seq_U2OS_Human1.65134957
44ESR1_21235772_ChIP-Seq_MCF-7_Human1.63771415
45RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.63173039
46* EST1_17652178_ChIP-ChIP_JURKAT_Human1.63028155
47SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.61904830
48ESR2_21235772_ChIP-Seq_MCF-7_Human1.61866017
49FOXM1_26456572_ChIP-Seq_MCF-7_Human1.61684031
50SMAD_19615063_ChIP-ChIP_OVARY_Human1.60863184
51NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.58095229
52GATA4_25053715_ChIP-Seq_YYC3_Human1.57723178
53MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.57576825
54KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.56877633
55OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.56798606
56PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.56436355
57IGF1R_20145208_ChIP-Seq_DFB_Human1.56370659
58* ER_23166858_ChIP-Seq_MCF-7_Human1.56051482
59STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.54979820
60SMAD4_21799915_ChIP-Seq_A2780_Human1.54779417
61BCAT_22108803_ChIP-Seq_LS180_Human1.54264395
62CTBP2_25329375_ChIP-Seq_LNCAP_Human1.52361220
63SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.52011224
64EZH2_27294783_Chip-Seq_NPCs_Mouse1.49390559
65ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.48229893
66SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.46023157
67NANOG_18555785_Chip-Seq_ESCs_Mouse1.45852824
68PCGF2_27294783_Chip-Seq_ESCs_Mouse1.45116081
69CDX2_19796622_ChIP-Seq_MESCs_Mouse1.44556367
70TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.44278132
71AR_21915096_ChIP-Seq_LNCaP-1F5_Human1.43686894
72SUZ12_27294783_Chip-Seq_NPCs_Mouse1.42845480
73SMAD3_21741376_ChIP-Seq_EPCs_Human1.40763455
74* HNF4A_19822575_ChIP-Seq_HepG2_Human1.38292515
75SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.38280182
76RARG_19884340_ChIP-ChIP_MEFs_Mouse1.38067531
77FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.36532318
78ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.35106564
79HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.34257336
80NFE2_27457419_Chip-Seq_LIVER_Mouse1.33311709
81EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.31027727
82ESR1_20079471_ChIP-ChIP_T-47D_Human1.30258132
83TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.29261811
84WT1_19549856_ChIP-ChIP_CCG9911_Human1.29256084
85* AR_25329375_ChIP-Seq_VCAP_Human1.29137381
86E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.28645685
87FOXO3_23340844_ChIP-Seq_DLD1_Human1.27323695
88CDX2_22108803_ChIP-Seq_LS180_Human1.26097331
89GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.25566796
90GATA6_25053715_ChIP-Seq_YYC3_Human1.25045159
91SOX2_20726797_ChIP-Seq_SW620_Human1.24428870
92MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.24011552
93CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.23497614
94TRIM28_21343339_ChIP-Seq_HEK293_Human1.22937159
95P53_22387025_ChIP-Seq_ESCs_Mouse1.22675673
96ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.22232181
97CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.21346801
98CMYC_18555785_Chip-Seq_ESCs_Mouse1.20968235
99STAT3_23295773_ChIP-Seq_U87_Human1.20374818
100* UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.19851318
101* KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.19086318
102E2F1_18555785_Chip-Seq_ESCs_Mouse1.18866795
103TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.18603982
104SUZ12_18555785_Chip-Seq_ESCs_Mouse1.18402584
105ZNF263_19887448_ChIP-Seq_K562_Human1.17063226
106CTBP1_25329375_ChIP-Seq_LNCAP_Human1.16943250
107LXR_22292898_ChIP-Seq_THP-1_Human1.16744854
108PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.15985904
109IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.15886149
110CBP_20019798_ChIP-Seq_JUKART_Human1.15886149
111BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.15326864
112FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human1.14908498
113P300_18555785_Chip-Seq_ESCs_Mouse1.14470043
114CDX2_20551321_ChIP-Seq_CACO-2_Human1.13900562
115TCF4_22108803_ChIP-Seq_LS180_Human1.13695398
116CRX_20693478_ChIP-Seq_RETINA_Mouse1.13274713
117ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.12656989
118E2F7_22180533_ChIP-Seq_HELA_Human1.10118436
119FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.10064979
120STAT3_18555785_Chip-Seq_ESCs_Mouse1.09167755
121PCGF2_27294783_Chip-Seq_NPCs_Mouse1.08892611
122SOX2_18555785_Chip-Seq_ESCs_Mouse1.08287815
123ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.07975744
124PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.07603429
125TOP2B_26459242_ChIP-Seq_MCF-7_Human1.07422355
126FOXP2_23625967_ChIP-Seq_PFSK-1_AND_SK-N-MC_Human1.06544286
127KLF5_20875108_ChIP-Seq_MESCs_Mouse1.06032718
128BRD4_25478319_ChIP-Seq_HGPS_Human1.05024949
129TCF4_23295773_ChIP-Seq_U87_Human1.04702441
130CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.03784077
131PPAR_26484153_Chip-Seq_NCI-H1993_Human1.03203031
132TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.03140760
133RBPJ_22232070_ChIP-Seq_NCS_Mouse1.02634798
134AHR_22903824_ChIP-Seq_MCF-7_Human1.01996898
135NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.01539883
136NR3C1_21868756_ChIP-Seq_MCF10A_Human1.01460232
137ARNT_22903824_ChIP-Seq_MCF-7_Human1.01392416
138CJUN_26792858_Chip-Seq_BT549_Human1.01062165
139OCT4_18555785_Chip-Seq_ESCs_Mouse1.00841926
140GATA2_19941826_ChIP-Seq_K562_Human1.00718465
141FOXA1_25552417_ChIP-Seq_VCAP_Human1.00607189
142ZNF217_24962896_ChIP-Seq_MCF-7_Human1.00396319
143EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse1.00260939
144PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse0.98976454
145THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse0.98668555
146SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse0.97831100
147RACK7_27058665_Chip-Seq_MCF-7_Human0.97685505
148ESR1_22446102_ChIP-Seq_UTERUS_Mouse0.97577466
149GATA1_19941826_ChIP-Seq_K562_Human0.95107791
150SALL4_18804426_ChIP-ChIP_XEN_Mouse0.93392152
151* GATA3_24758297_ChIP-Seq_MCF-7_Human0.91716163
152KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human0.90627806
153FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human0.90563743
154P300_27058665_Chip-Seq_ZR-75-30cells_Human0.88395061
155TBX20_22328084_ChIP-Seq_HEART_Mouse0.85719164
156TBX20_22080862_ChIP-Seq_HEART_Mouse0.85719164
157RUNX1_27514584_Chip-Seq_MCF-7_Human0.85150728
158E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human0.83707313
159PRDM5_23873026_ChIP-Seq_MEFs_Mouse0.80572712
160ATF3_27146783_Chip-Seq_COLON_Human0.80218621
161SOX9_24532713_ChIP-Seq_HFSC_Mouse0.78315941
162IRF1_21803131_ChIP-Seq_MONOCYTES_Human0.77524888
163CREB1_26743006_Chip-Seq_LNCaP_Human0.76813328
164HIF1A_21447827_ChIP-Seq_MCF-7_Human0.76682783
165TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse0.76064774
166NRF2_20460467_ChIP-Seq_MEFs_Mouse0.74274363
167NFE2L2_20460467_ChIP-Seq_MEFs_Mouse0.74274363
168GATA1_19941827_ChIP-Seq_MEL_Mouse0.73759024
169NFIB_24661679_ChIP-Seq_LUNG_Mouse0.73425098
170KDM2B_26808549_Chip-Seq_HPB-ALL_Human0.70309578
171FOXA1_26743006_Chip-Seq_LNCaP-abl_Human0.69781783
172NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse0.69428176
173PPARD_23208498_ChIP-Seq_MDA-MB-231_Human0.69277450
174FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.69199449
175TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse0.68137945
176GATA3_20176728_ChIP-ChIP_TSCs_Mouse0.68105620
177HTT_18923047_ChIP-ChIP_STHdh_Human0.67896336
178RXRA_24833708_ChIP-Seq_LIVER_Mouse0.66021737
179SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.64682228
180ESR1_15608294_ChIP-ChIP_MCF-7_Human0.64340147
181* SREBP2_21459322_ChIP-Seq_LIVER_Mouse0.64190232
182MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human0.63609260
183Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse0.63030422
184CREB1_26743006_Chip-Seq_LNCaP-abl_Human0.62991257
185ERG_21242973_ChIP-ChIP_JURKAT_Human0.62240561
186MYC_22102868_ChIP-Seq_BL_Human0.61514938
187RXR_22108803_ChIP-Seq_LS180_Human0.61421554
188CTNNB1_20460455_ChIP-Seq_HCT116_Human0.61278682
189BRD4_27068464_Chip-Seq_AML-cells_Mouse0.61151387
190DMRT1_23473982_ChIP-Seq_TESTES_Mouse0.60397031

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002139_abnormal_hepatobiliary_system6.77736833
2MP0005360_urolithiasis6.29743051
3MP0005365_abnormal_bile_salt5.27253697
4MP0005085_abnormal_gallbladder_physiolo4.88754501
5MP0008875_abnormal_xenobiotic_pharmacok3.78098370
6MP0001666_abnormal_nutrient_absorption3.77550418
7MP0003252_abnormal_bile_duct3.70468059
8MP0010329_abnormal_lipoprotein_level3.15277155
9MP0002102_abnormal_ear_morphology2.91235460
10MP0009840_abnormal_foam_cell2.86974929
11MP0000372_irregular_coat_pigmentation2.86412958
12MP0005083_abnormal_biliary_tract2.73623583
13MP0003195_calcinosis2.45351522
14MP0010234_abnormal_vibrissa_follicle2.41747303
15MP0005367_renal/urinary_system_phenotyp2.39818695
16MP0000516_abnormal_urinary_system2.39818695
17MP0003806_abnormal_nucleotide_metabolis2.36859139
18MP0005332_abnormal_amino_acid2.32223245
19MP0008877_abnormal_DNA_methylation2.27724407
20MP0003300_gastrointestinal_ulcer2.27192341
21MP0003868_abnormal_feces_composition2.21646527
22MP0002938_white_spotting2.18901649
23MP0003787_abnormal_imprinting2.17980832
24MP0005379_endocrine/exocrine_gland_phen2.16754015
25MP0000427_abnormal_hair_cycle2.05228579
26MP0003191_abnormal_cellular_cholesterol2.02154864
27MP0005220_abnormal_exocrine_pancreas2.01265183
28MP0002118_abnormal_lipid_homeostasis1.99312711
29MP0003705_abnormal_hypodermis_morpholog1.99204288
30MP0000609_abnormal_liver_physiology1.97297470
31MP0002138_abnormal_hepatobiliary_system1.95890770
32MP0009780_abnormal_chondrocyte_physiolo1.90888843
33MP0008057_abnormal_DNA_replication1.85221862
34MP0010678_abnormal_skin_adnexa1.84121016
35MP0003950_abnormal_plasma_membrane1.71819957
36MP0010094_abnormal_chromosome_stability1.66943563
37MP0009643_abnormal_urine_homeostasis1.65476580
38MP0003122_maternal_imprinting1.64503237
39MP0005319_abnormal_enzyme/_coenzyme1.63746121
40MP0003183_abnormal_peptide_metabolism1.63470589
41MP0004264_abnormal_extraembryonic_tissu1.62788246
42MP0004019_abnormal_vitamin_homeostasis1.60358281
43MP0006072_abnormal_retinal_apoptosis1.58212008
44MP0003123_paternal_imprinting1.56921972
45MP0002837_dystrophic_cardiac_calcinosis1.56624854
46MP0000647_abnormal_sebaceous_gland1.56621948
47MP0003121_genomic_imprinting1.55758377
48MP0002163_abnormal_gland_morphology1.55054864
49MP0004043_abnormal_pH_regulation1.54318949
50MP0005058_abnormal_lysosome_morphology1.53409649
51MP0002909_abnormal_adrenal_gland1.49034248
52MP0006054_spinal_hemorrhage1.44839015
53MP0003011_delayed_dark_adaptation1.44299809
54MP0002090_abnormal_vision1.41895321
55MP0005075_abnormal_melanosome_morpholog1.41756429
56MP0003693_abnormal_embryo_hatching1.38044950
57MP0005171_absent_coat_pigmentation1.34952844
58MP0008058_abnormal_DNA_repair1.34715861
59MP0005187_abnormal_penis_morphology1.34224451
60MP0005253_abnormal_eye_physiology1.32926297
61MP0003718_maternal_effect1.29953166
62MP0005395_other_phenotype1.28114115
63MP0003941_abnormal_skin_development1.28043763
64MP0003283_abnormal_digestive_organ1.26422933
65MP0000569_abnormal_digit_pigmentation1.26379653
66MP0001944_abnormal_pancreas_morphology1.25627845
67MP0005584_abnormal_enzyme/coenzyme_acti1.24461481
68MP0002078_abnormal_glucose_homeostasis1.20969332
69MP0000383_abnormal_hair_follicle1.17531444
70MP0003890_abnormal_embryonic-extraembry1.15394798
71MP0003656_abnormal_erythrocyte_physiolo1.14564704
72MP0000604_amyloidosis1.14239982
73MP0002751_abnormal_autonomic_nervous1.11808543
74MP0004130_abnormal_muscle_cell1.08808227
75MP0001756_abnormal_urination1.08716723
76MP0003943_abnormal_hepatobiliary_system1.08075876
77MP0005551_abnormal_eye_electrophysiolog1.07507008
78MP0005636_abnormal_mineral_homeostasis1.06399118
79MP0010386_abnormal_urinary_bladder1.06324622
80MP0003937_abnormal_limbs/digits/tail_de1.04631173
81MP0008961_abnormal_basal_metabolism1.03736281
82MP0000598_abnormal_liver_morphology1.03519804
83MP0002877_abnormal_melanocyte_morpholog1.01926943
84MP0000013_abnormal_adipose_tissue1.01508834
85MP0000015_abnormal_ear_pigmentation1.00403822
86MP0005646_abnormal_pituitary_gland0.99721480
87MP0005174_abnormal_tail_pigmentation0.99233764
88MP0003786_premature_aging0.96761724
89MP0010307_abnormal_tumor_latency0.95834424
90MP0001324_abnormal_eye_pigmentation0.95591778
91MP0002693_abnormal_pancreas_physiology0.94611673
92MP0001764_abnormal_homeostasis0.94562565
93MP0004134_abnormal_chest_morphology0.93909436
94MP0002896_abnormal_bone_mineralization0.92627342
95MP0009703_decreased_birth_body0.90854599
96MP0002233_abnormal_nose_morphology0.90411635
97MP0009384_cardiac_valve_regurgitation0.90394990
98MP0002234_abnormal_pharynx_morphology0.88381978
99MP0001984_abnormal_olfaction0.88330630
100MP0001765_abnormal_ion_homeostasis0.87978671
101MP0002928_abnormal_bile_duct0.87609386
102MP0003186_abnormal_redox_activity0.87362557
103MP0003172_abnormal_lysosome_physiology0.86280626
104MP0009642_abnormal_blood_homeostasis0.84265737
105MP0005084_abnormal_gallbladder_morpholo0.83809875
106MP0005448_abnormal_energy_balance0.83062708
107MP0001529_abnormal_vocalization0.82423696
108MP0004957_abnormal_blastocyst_morpholog0.81188582
109MP0003329_amyloid_beta_deposits0.80970953
110MP0003755_abnormal_palate_morphology0.80392906
111MP0000462_abnormal_digestive_system0.80105460
112MP0000377_abnormal_hair_follicle0.80082388
113MP0002254_reproductive_system_inflammat0.79644618
114MP0005670_abnormal_white_adipose0.79207777
115MP0002295_abnormal_pulmonary_circulatio0.78993120
116MP0004215_abnormal_myocardial_fiber0.77307747
117MP0000371_diluted_coat_color0.76360835
118MP0000631_abnormal_neuroendocrine_gland0.76328306
119MP0000003_abnormal_adipose_tissue0.74973868
120MP0005666_abnormal_adipose_tissue0.73061410
121MP0005334_abnormal_fat_pad0.72299419
122MP0005647_abnormal_sex_gland0.71868555
123MP0004133_heterotaxia0.71523465
124MP0001929_abnormal_gametogenesis0.71311722
125MP0003953_abnormal_hormone_level0.70722755
126MP0002282_abnormal_trachea_morphology0.69513800
127MP0003111_abnormal_nucleus_morphology0.68949202
128MP0002136_abnormal_kidney_physiology0.68871542
129MP0003935_abnormal_craniofacial_develop0.68833862
130MP0002089_abnormal_postnatal_growth/wei0.68143608
131MP0002166_altered_tumor_susceptibility0.68083701
132MP0003690_abnormal_glial_cell0.66817647
133MP0010352_gastrointestinal_tract_polyps0.66305171
134MP0001663_abnormal_digestive_system0.65096974
135MP0008469_abnormal_protein_level0.64051129
136MP0004185_abnormal_adipocyte_glucose0.63824521
137MP0005451_abnormal_body_composition0.63666990
138MP0005375_adipose_tissue_phenotype0.63193283
139MP0009764_decreased_sensitivity_to0.62426495
140MP0005408_hypopigmentation0.61101188
141MP0001664_abnormal_digestion0.60896422
142MP0005381_digestive/alimentary_phenotyp0.60742902
143MP0000639_abnormal_adrenal_gland0.59593603
144MP0002971_abnormal_brown_adipose0.58507014
145MP0003638_abnormal_response/metabolism_0.58451852
146MP0001873_stomach_inflammation0.58066988
147MP0001270_distended_abdomen0.56402395
148MP0010368_abnormal_lymphatic_system0.56066186
149MP0005076_abnormal_cell_differentiation0.55878118
150MP0005248_abnormal_Harderian_gland0.55457353
151MP0009697_abnormal_copulation0.55215409
152MP0005535_abnormal_body_temperature0.55180336
153MP0002796_impaired_skin_barrier0.54946225
154MP0002168_other_aberrant_phenotype0.53668065
155MP0009763_increased_sensitivity_to0.52456374
156MP0000538_abnormal_urinary_bladder0.52128808
157MP0002876_abnormal_thyroid_physiology0.49635096
158MP0004782_abnormal_surfactant_physiolog0.48454498
159MP0009765_abnormal_xenobiotic_induced0.47813103
160MP0001881_abnormal_mammary_gland0.47172388
161MP0000230_abnormal_systemic_arterial0.47049194
162MP0003866_abnormal_defecation0.46323777
163MP0003075_altered_response_to0.46151915
164MP0004947_skin_inflammation0.46016709
165MP0000613_abnormal_salivary_gland0.45230366

Predicted human phenotypes

RankGene SetZ-score
1Intrahepatic cholestasis (HP:0001406)5.56412990
2Deep venous thrombosis (HP:0002625)5.14164414
3Abnormality of aromatic amino acid family metabolism (HP:0004338)5.02496658
4Xanthomatosis (HP:0000991)4.78637672
5Abnormality of monocarboxylic acid metabolism (HP:0010996)4.69227112
6Hypobetalipoproteinemia (HP:0003563)4.59764013
7Hypoglycemic coma (HP:0001325)4.27279317
8Ketosis (HP:0001946)4.17078711
9Ketoacidosis (HP:0001993)4.14503128
10Hypothermia (HP:0002045)3.94613343
11Intestinal atresia (HP:0011100)3.83880658
12Abnormality of the intrinsic pathway (HP:0010989)3.78763788
13Fat malabsorption (HP:0002630)3.74735869
14Abnormality of the common coagulation pathway (HP:0010990)3.72017453
15Hyperlipoproteinemia (HP:0010980)3.67242680
16Hypolipoproteinemia (HP:0010981)3.66558201
17Prolonged partial thromboplastin time (HP:0003645)3.63119695
18Abnormality of glutamine family amino acid metabolism (HP:0010902)3.57573256
19Conjugated hyperbilirubinemia (HP:0002908)3.54389476
20Complement deficiency (HP:0004431)3.47951528
21Hyperammonemia (HP:0001987)3.43010643
22Hypoglycemic seizures (HP:0002173)3.41865385
23Hyperglycinuria (HP:0003108)3.41440743
24Pancreatic islet-cell hyperplasia (HP:0004510)3.33473102
25Gout (HP:0001997)3.27858494
26Hypoalphalipoproteinemia (HP:0003233)3.26163475
27Abnormality of the level of lipoprotein cholesterol (HP:0010979)3.24927862
28Abnormality of glycine metabolism (HP:0010895)3.24007105
29Abnormality of serine family amino acid metabolism (HP:0010894)3.24007105
30Abnormality of sulfur amino acid metabolism (HP:0004339)3.21799520
31Neoplasm of the adrenal cortex (HP:0100641)3.18899035
32Symptomatic seizures (HP:0011145)3.13141798
33Enlarged penis (HP:0000040)3.12255271
34Abnormality of purine metabolism (HP:0004352)3.01599522
35Large for gestational age (HP:0001520)3.00469684
36Hyperglycinemia (HP:0002154)3.00123463
37Epidermoid cyst (HP:0200040)2.93299719
38Abnormality of long-chain fatty-acid metabolism (HP:0010964)2.92330577
39Hyperinsulinemic hypoglycemia (HP:0000825)2.90832950
40Abnormal tarsal ossification (HP:0008369)2.87736059
41Abnormality of fatty-acid metabolism (HP:0004359)2.85375906
42Protuberant abdomen (HP:0001538)2.79616602
43Late onset (HP:0003584)2.78302803
44Aqueductal stenosis (HP:0002410)2.77712958
45Steatorrhea (HP:0002570)2.62897272
46Hyperbilirubinemia (HP:0002904)2.59728610
47Hyperglycemia (HP:0003074)2.59402747
48Urinary glycosaminoglycan excretion (HP:0003541)2.57400924
49Mucopolysacchariduria (HP:0008155)2.57400924
50Neoplasm of the adrenal gland (HP:0100631)2.56422738
51Generalized aminoaciduria (HP:0002909)2.54553177
52Abnormality of nucleobase metabolism (HP:0010932)2.50405083
53Abnormality of the pancreatic islet cells (HP:0006476)2.49472332
54Abnormality of endocrine pancreas physiology (HP:0012093)2.49472332
55Skin nodule (HP:0200036)2.48174766
56Abnormality of aspartate family amino acid metabolism (HP:0010899)2.45617525
57Joint hemorrhage (HP:0005261)2.45361016
58Hepatocellular carcinoma (HP:0001402)2.43277897
59Volvulus (HP:0002580)2.41760594
60Abnormality of the renal cortex (HP:0011035)2.40083586
61Hypercholesterolemia (HP:0003124)2.38736972
62Abnormality of complement system (HP:0005339)2.37365085
63Sensory axonal neuropathy (HP:0003390)2.33991897
64Elevated circulating parathyroid hormone (PTH) level (HP:0003165)2.32947745
65Dysostosis multiplex (HP:0000943)2.31622981
66Abnormality of polysaccharide metabolism (HP:0011012)2.31378244
67Abnormality of glycosaminoglycan metabolism (HP:0004371)2.31378244
68Abnormality of mucopolysaccharide metabolism (HP:0011020)2.31378244
69Abnormality of proline metabolism (HP:0010907)2.31358634
70Hydroxyprolinuria (HP:0003080)2.31358634
71Malnutrition (HP:0004395)2.27486017
72Tongue fasciculations (HP:0001308)2.27231251
73Acanthocytosis (HP:0001927)2.26280136
74Mitral stenosis (HP:0001718)2.25959906
75Back pain (HP:0003418)2.25739596
76Myocardial infarction (HP:0001658)2.25618951
77Abdominal distention (HP:0003270)2.24823766
78Abnormal foot bone ossification (HP:0010675)2.24166537
79Rhabdomyosarcoma (HP:0002859)2.22739863
80Renal cortical cysts (HP:0000803)2.20626956
81Pancreatic cysts (HP:0001737)2.20069256
82Hyperventilation (HP:0002883)2.19556206
83Vascular calcification (HP:0004934)2.17330483
84Thyroiditis (HP:0100646)2.17248765
85Abnormality of vitamin B metabolism (HP:0004340)2.17042879
86Delayed gross motor development (HP:0002194)2.15826042
87Hamartoma of the eye (HP:0010568)2.15786260
88Sensorimotor neuropathy (HP:0007141)2.15476028
89Delayed CNS myelination (HP:0002188)2.14125984
90Abnormality of the astrocytes (HP:0100707)2.13476360
91Astrocytoma (HP:0009592)2.13476360
92Abnormality of chromosome stability (HP:0003220)2.11893512
93Ependymoma (HP:0002888)2.10994021
94Abnormality of the labia minora (HP:0012880)2.10275060
95Abnormal enzyme/coenzyme activity (HP:0012379)2.07608380
96Metabolic acidosis (HP:0001942)2.07430856
97Irritability (HP:0000737)2.05312682
98Cardiovascular calcification (HP:0011915)2.03065206
99Increased purine levels (HP:0004368)2.03056550
100Hyperuricemia (HP:0002149)2.03056550
101Thyroid carcinoma (HP:0002890)2.02798674
102Esophageal varix (HP:0002040)2.02275525
103Abnormality of methionine metabolism (HP:0010901)2.02113769
104Abnormal cartilage morphology (HP:0002763)2.01664429
105Turricephaly (HP:0000262)2.00691510
106Bilateral sensorineural hearing impairment (HP:0008619)1.99402724
107Glioma (HP:0009733)1.98641544
108Methylmalonic acidemia (HP:0002912)1.98433786
109Molar tooth sign on MRI (HP:0002419)1.97452996
110Abnormality of midbrain morphology (HP:0002418)1.97452996
111Patchy hypopigmentation of hair (HP:0011365)1.94769269
112Pancreatitis (HP:0001733)1.94578593
113Elevated alkaline phosphatase (HP:0003155)1.92454347
114Abnormality of alkaline phosphatase activity (HP:0004379)1.92324345
115Abnormal gallbladder morphology (HP:0012437)1.92030680
116Spastic diplegia (HP:0001264)1.91756711
117Breast carcinoma (HP:0003002)1.90159790
118Long toe (HP:0010511)1.89147370
119Abnormality of vitamin metabolism (HP:0100508)1.87890487
120Gastrointestinal atresia (HP:0002589)1.87713270
121Abnormal biliary tract morphology (HP:0012440)1.87484430
122Papillary thyroid carcinoma (HP:0002895)1.86378164
123Aplasia/Hypoplasia of the fovea (HP:0008060)1.86251632
124Hypoplasia of the fovea (HP:0007750)1.86251632
125Tubular atrophy (HP:0000092)1.84320443
126Hypomagnesemia (HP:0002917)1.84119977
127Conjunctival hamartoma (HP:0100780)1.84036139
128Curly hair (HP:0002212)1.84005192
129Abnormality of the duodenum (HP:0002246)1.81990124
130Insulin resistance (HP:0000855)1.81211557
131Pancreatic fibrosis (HP:0100732)1.80947293
132Dicarboxylic aciduria (HP:0003215)1.80555447
133Abnormality of dicarboxylic acid metabolism (HP:0010995)1.80555447
134Generalized myoclonic seizures (HP:0002123)1.80487520
135Right ventricular cardiomyopathy (HP:0011663)1.80275087
136Cutaneous melanoma (HP:0012056)1.80014290
137EEG with generalized epileptiform discharges (HP:0011198)1.79623582
138Abnormal sex determination (HP:0012244)1.79274439
139Sex reversal (HP:0012245)1.79274439
140True hermaphroditism (HP:0010459)1.77726425
141Prominent metopic ridge (HP:0005487)1.77046008
142Abnormality of macular pigmentation (HP:0008002)1.74697037
143Medial flaring of the eyebrow (HP:0010747)1.73364577
144Abnormality of the metopic suture (HP:0005556)1.72080463
145Hypokinesia (HP:0002375)1.71460072
146Widely patent fontanelles and sutures (HP:0004492)1.71246438
147Bifid tongue (HP:0010297)1.69665223
148Epileptiform EEG discharges (HP:0011182)1.69259040
149Hypsarrhythmia (HP:0002521)1.69028232
150Insulin-resistant diabetes mellitus (HP:0000831)1.68272398
151Lymphangioma (HP:0100764)1.67909383
152Retinal atrophy (HP:0001105)1.67774984
153Aplasia/Hypoplasia of the uvula (HP:0010293)1.67735361
154Meckel diverticulum (HP:0002245)1.67683464
155Alkalosis (HP:0001948)1.67545788
156Adrenal hypoplasia (HP:0000835)1.67436795
157Proximal tubulopathy (HP:0000114)1.67322356
158Abnormality of the gallbladder (HP:0005264)1.67284183
159Muscle fibrillation (HP:0010546)1.66194326
160Nephrolithiasis (HP:0000787)1.66163546
161Abnormal pancreas size (HP:0012094)1.66096506
162Overlapping toe (HP:0001845)1.66014048
163Aneurysm (HP:0002617)1.64841509
164Aortic aneurysm (HP:0004942)1.64830491
165Progressive inability to walk (HP:0002505)1.64773203
166Abnormality of the ileum (HP:0001549)1.64160008
167Muscular hypotonia of the trunk (HP:0008936)1.61127708
168Abnormality of the fovea (HP:0000493)1.60989293
169Tubulointerstitial nephritis (HP:0001970)1.60368686
170Hemiparesis (HP:0001269)1.60204782
171Furrowed tongue (HP:0000221)1.60172337
172Congenital malformation of the right heart (HP:0011723)1.59641971
173Double outlet right ventricle (HP:0001719)1.59641971
174Abnormality of the preputium (HP:0100587)1.58745975
175Meningioma (HP:0002858)1.57936393
176Nephronophthisis (HP:0000090)1.55738712
177Abnormality of the renal medulla (HP:0100957)1.53228122
178Sloping forehead (HP:0000340)1.52932432
179Progressive macrocephaly (HP:0004481)1.51865685

Predicted kinase interactions (KEA)

RankGene SetZ-score
1ERN14.75990684
2TRIB34.41188511
3FRK3.61376649
4BCKDK3.50091987
5TRIM283.47904568
6SIK13.45019850
7PKN23.34318659
8INSRR3.06879668
9TAOK32.91132038
10MST42.71711410
11LMTK22.68688679
12WEE12.49735764
13PNCK2.42391704
14ERBB32.41913004
15EIF2AK12.36271569
16BUB12.23123865
17PTK62.18714423
18FGFR42.14961166
19MKNK22.10611512
20BMPR1B1.98357476
21CASK1.97098627
22LATS11.95532336
23MAP3K21.94573926
24PLK31.92510685
25MAP3K121.87809727
26STK391.75931411
27ACVR1B1.74469689
28RIPK11.63227165
29PIK3CG1.52854067
30SCYL21.50214454
31EPHB11.47752657
32PLK21.46015236
33NLK1.43027815
34TAF11.40971167
35BCR1.40821351
36TTK1.36595370
37TNIK1.32158697
38STK38L1.30178652
39MAP3K31.30136113
40PBK1.28346519
41NEK11.27647795
42FLT31.27315013
43TSSK61.25127416
44MST1R1.23890045
45MAPK151.23669369
46TGFBR21.21842339
47PDGFRA1.20426475
48MKNK11.17617220
49EEF2K1.17490437
50CSNK1G11.15911433
51NTRK11.15613765
52MAP3K101.12068470
53AKT31.10217687
54GRK11.09313471
55STK31.08826008
56WNK31.07883970
57ZAK1.06742802
58RET1.05566522
59OXSR11.05361948
60MAP3K71.05188933
61PLK41.01785165
62JAK11.01249007
63FGFR21.01165280
64EIF2AK20.99781850
65MAPK130.98614809
66CAMK1D0.98000083
67MAP3K10.97363138
68EPHA30.96254187
69MAP4K20.94228059
70PTK20.93027114
71LRRK20.92159940
72SGK30.90957154
73PLK10.90436678
74CCNB10.88421989
75JAK20.87208613
76PRKCH0.84712259
77TYK20.84190176
78EIF2AK30.83864326
79ERBB20.83818938
80PASK0.82778552
81MUSK0.81311148
82PRKCE0.80936119
83FER0.79763593
84CAMKK10.79239612
85NEK90.78281517
86FGFR30.78039061
87HIPK20.77360566
88TRPM70.73845195
89MAPK110.73323917
90BRSK10.72892010
91YES10.72637326
92KSR20.72390135
93BMPR20.72047412
94PDK20.70708279
95PRKG20.70354878
96MTOR0.69900060
97MAP2K20.69122352
98CDK60.67860417
99VRK10.66183097
100MAP2K30.65643731
101PTK2B0.65450888
102CAMK1G0.65290411
103SGK20.63380004
104FGFR10.62168090
105IRAK30.61968896
106DAPK20.61524158
107BRD40.61236274
108PRKAA10.61105588
109JAK30.60250279
110KSR10.58940888
111MAP2K40.58898081
112MAP3K40.57178849
113PRKAA20.57101310
114ATM0.56593329
115ADRBK20.56205704
116ICK0.55448110
117SIK30.55064715
118MAP2K10.54933090
119STK40.54425154
120GRK60.53944538
121PRKD30.52959695
122STK240.52389884
123MET0.51382738
124DDR20.50657881
125TIE10.50486090
126CSNK1G30.50299286
127SGK2230.49948723
128SGK4940.49948723
129TAOK10.48981173
130MATK0.48905743
131CDK30.47222039
132MAPKAPK30.46948330
133TBK10.46826106
134EPHB20.46757001
135PAK20.46439029
136WNK40.46437799
137ROCK10.45981968
138PDPK10.45585546
139ZAP700.45487102
140PRKCI0.45023210
141VRK20.44868714
142ERBB40.44750929
143PRKCG0.44637106
144CAMK2D0.43504203
145PAK30.43332325
146NUAK10.43090869
147CSNK1G20.42977923
148GSK3A0.42834353
149MELK0.41762895
150IRAK10.41670169
151PRKACG0.41225932
152PIK3CA0.39114089
153AURKB0.37867880
154ATR0.37091586
155EGFR0.36971447
156MINK10.36921995
157NEK60.36587768
158BRSK20.35550178
159CAMKK20.34927436
160PDK10.34003729
161TGFBR10.33196601
162PDGFRB0.33150695
163PRKCZ0.31788369
164CSNK1A1L0.31315991
165NTRK30.29611723
166PHKG20.27003941
167PHKG10.27003941
168MYLK0.25674147
169EPHA20.24393464

Predicted pathways (KEGG)

RankGene SetZ-score
1Nitrogen metabolism_Homo sapiens_hsa009103.44184547
2Primary bile acid biosynthesis_Homo sapiens_hsa001203.34097371
3Non-homologous end-joining_Homo sapiens_hsa034502.99552702
4Ascorbate and aldarate metabolism_Homo sapiens_hsa000532.79411831
5Maturity onset diabetes of the young_Homo sapiens_hsa049502.76702663
6Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004002.51333017
7Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010402.50369098
8Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.48988379
9Fatty acid degradation_Homo sapiens_hsa000712.48199283
10Tryptophan metabolism_Homo sapiens_hsa003802.41752373
11Arginine biosynthesis_Homo sapiens_hsa002202.40914479
12Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006302.20571697
13Terpenoid backbone biosynthesis_Homo sapiens_hsa009002.11252565
14Sulfur metabolism_Homo sapiens_hsa009202.10594885
15Butanoate metabolism_Homo sapiens_hsa006502.08655175
16Fatty acid metabolism_Homo sapiens_hsa012121.96132687
17Proteasome_Homo sapiens_hsa030501.92299906
18Fat digestion and absorption_Homo sapiens_hsa049751.92252421
19Selenocompound metabolism_Homo sapiens_hsa004501.91530657
20Propanoate metabolism_Homo sapiens_hsa006401.86402136
21Bile secretion_Homo sapiens_hsa049761.85073539
22Complement and coagulation cascades_Homo sapiens_hsa046101.82116230
23Pentose and glucuronate interconversions_Homo sapiens_hsa000401.79142364
24Caffeine metabolism_Homo sapiens_hsa002321.77664826
25Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.75630374
26PPAR signaling pathway_Homo sapiens_hsa033201.74358114
27Peroxisome_Homo sapiens_hsa041461.62899485
28Starch and sucrose metabolism_Homo sapiens_hsa005001.58150854
29Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.57419598
302-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.57307912
31Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.55209027
32Sphingolipid metabolism_Homo sapiens_hsa006001.51663552
33Histidine metabolism_Homo sapiens_hsa003401.51205363
34Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.48541301
35Fanconi anemia pathway_Homo sapiens_hsa034601.48394019
36Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.41870147
37Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.41722307
38beta-Alanine metabolism_Homo sapiens_hsa004101.37121489
39Basal transcription factors_Homo sapiens_hsa030221.37064077
40Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.33430456
41ABC transporters_Homo sapiens_hsa020101.31204964
42Chemical carcinogenesis_Homo sapiens_hsa052041.29584510
43Pyruvate metabolism_Homo sapiens_hsa006201.26384309
44Collecting duct acid secretion_Homo sapiens_hsa049661.26222567
45Drug metabolism - other enzymes_Homo sapiens_hsa009831.24841660
46Vitamin digestion and absorption_Homo sapiens_hsa049771.24634711
47Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.24287507
48Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.22843005
49Circadian rhythm_Homo sapiens_hsa047101.20915213
50Homologous recombination_Homo sapiens_hsa034401.20484117
51Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.18432494
52Folate biosynthesis_Homo sapiens_hsa007901.18028789
53Phenylalanine metabolism_Homo sapiens_hsa003601.13465698
54Steroid hormone biosynthesis_Homo sapiens_hsa001401.12166522
55Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.11915369
56Steroid biosynthesis_Homo sapiens_hsa001001.10770269
57Mismatch repair_Homo sapiens_hsa034301.10500494
58Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.07860307
59Carbon metabolism_Homo sapiens_hsa012001.04453285
60Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.00490243
61Biosynthesis of amino acids_Homo sapiens_hsa012300.97964609
62Glycerolipid metabolism_Homo sapiens_hsa005610.97765152
63Lysine degradation_Homo sapiens_hsa003100.92717983
64RNA degradation_Homo sapiens_hsa030180.92288713
65Fatty acid elongation_Homo sapiens_hsa000620.92269692
66Retinol metabolism_Homo sapiens_hsa008300.91773357
67TGF-beta signaling pathway_Homo sapiens_hsa043500.91236321
68Staphylococcus aureus infection_Homo sapiens_hsa051500.90894275
69Cyanoamino acid metabolism_Homo sapiens_hsa004600.84044108
70Vibrio cholerae infection_Homo sapiens_hsa051100.83784474
71Carbohydrate digestion and absorption_Homo sapiens_hsa049730.83618500
72Cysteine and methionine metabolism_Homo sapiens_hsa002700.82634651
73Tyrosine metabolism_Homo sapiens_hsa003500.82005511
74Oocyte meiosis_Homo sapiens_hsa041140.81881152
75Oxidative phosphorylation_Homo sapiens_hsa001900.77807979
76Ether lipid metabolism_Homo sapiens_hsa005650.77062831
77Renin-angiotensin system_Homo sapiens_hsa046140.76989749
78Protein digestion and absorption_Homo sapiens_hsa049740.76688058
79p53 signaling pathway_Homo sapiens_hsa041150.75956369
80Insulin resistance_Homo sapiens_hsa049310.75137746
81Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.74050129
82RNA transport_Homo sapiens_hsa030130.72888904
83Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.70421678
84Phototransduction_Homo sapiens_hsa047440.69446816
85Nucleotide excision repair_Homo sapiens_hsa034200.68766873
86Galactose metabolism_Homo sapiens_hsa000520.67299217
87Glycosaminoglycan degradation_Homo sapiens_hsa005310.66893924
88Cell cycle_Homo sapiens_hsa041100.65591731
89N-Glycan biosynthesis_Homo sapiens_hsa005100.65525602
90Arginine and proline metabolism_Homo sapiens_hsa003300.63695152
91Regulation of autophagy_Homo sapiens_hsa041400.63073385
92Linoleic acid metabolism_Homo sapiens_hsa005910.61823792
93Sulfur relay system_Homo sapiens_hsa041220.61800564
94Fatty acid biosynthesis_Homo sapiens_hsa000610.57455801
95Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.55949767
96Pentose phosphate pathway_Homo sapiens_hsa000300.55572668
97Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.54430374
98Lysosome_Homo sapiens_hsa041420.53121615
99Fructose and mannose metabolism_Homo sapiens_hsa000510.52334485
100Glutathione metabolism_Homo sapiens_hsa004800.52276023
101RNA polymerase_Homo sapiens_hsa030200.51016459
102Type II diabetes mellitus_Homo sapiens_hsa049300.49331437
103Pancreatic secretion_Homo sapiens_hsa049720.49126712
104Adipocytokine signaling pathway_Homo sapiens_hsa049200.48675340
105Thyroid hormone synthesis_Homo sapiens_hsa049180.48055145
106alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.47177483
107Hippo signaling pathway_Homo sapiens_hsa043900.44172779
108Glucagon signaling pathway_Homo sapiens_hsa049220.41645910
109Insulin secretion_Homo sapiens_hsa049110.41004119
110Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.40088549
111Wnt signaling pathway_Homo sapiens_hsa043100.40019706
112AMPK signaling pathway_Homo sapiens_hsa041520.38618604
113Hedgehog signaling pathway_Homo sapiens_hsa043400.38252887
114Protein export_Homo sapiens_hsa030600.37624436
115Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.36184675
116Tight junction_Homo sapiens_hsa045300.35023525
117Mineral absorption_Homo sapiens_hsa049780.34473376
118Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.34440401
119Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.34311324
120Insulin signaling pathway_Homo sapiens_hsa049100.33182382
121Purine metabolism_Homo sapiens_hsa002300.32830820
122Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.31457393
123Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.30783652
124Vitamin B6 metabolism_Homo sapiens_hsa007500.30266270
125Metabolic pathways_Homo sapiens_hsa011000.25243099
126Other glycan degradation_Homo sapiens_hsa005110.24679999
127Glycerophospholipid metabolism_Homo sapiens_hsa005640.21766871
128Prion diseases_Homo sapiens_hsa050200.20818713
129Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.20472950
130Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.18930767
131One carbon pool by folate_Homo sapiens_hsa006700.17872069
132Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.17723369
133Central carbon metabolism in cancer_Homo sapiens_hsa052300.15668466
134Bladder cancer_Homo sapiens_hsa052190.15541555
135Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.15038779
136Longevity regulating pathway - mammal_Homo sapiens_hsa042110.14549157

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