SLC3A1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a type II membrane glycoprotein which is one of the components of the renal amino acid transporter which transports neutral and basic amino acids in the renal tubule and intestinal tract. Mutations and deletions in this gene are associated with cystinuria. Alternatively spliced transcript variants have been described, but their biological validity has not been determined. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1angiotensin maturation (GO:0002003)7.56224803
2lysine catabolic process (GO:0006554)7.41076874
3lysine metabolic process (GO:0006553)7.41076874
4urate metabolic process (GO:0046415)7.25869978
5drug transmembrane transport (GO:0006855)7.22235230
6cysteine metabolic process (GO:0006534)6.72045616
7erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)6.59184456
8L-phenylalanine catabolic process (GO:0006559)6.59184456
9aromatic amino acid family catabolic process (GO:0009074)6.51410526
10L-phenylalanine metabolic process (GO:0006558)6.44826260
11erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)6.44826260
12glyoxylate metabolic process (GO:0046487)6.44718300
13indolalkylamine catabolic process (GO:0046218)6.34748926
14tryptophan catabolic process (GO:0006569)6.34748926
15indole-containing compound catabolic process (GO:0042436)6.34748926
16drug transport (GO:0015893)6.21209139
17regulation of guanylate cyclase activity (GO:0031282)6.02098079
18tryptophan metabolic process (GO:0006568)5.94101743
19kynurenine metabolic process (GO:0070189)5.81068438
20regulation of systemic arterial blood pressure by renin-angiotensin (GO:0003081)5.67911440
21epoxygenase P450 pathway (GO:0019373)5.67261841
22homocysteine metabolic process (GO:0050667)5.57808216
23drug catabolic process (GO:0042737)5.50728654
24fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)5.25974250
25organic cation transport (GO:0015695)5.23880611
26serine family amino acid catabolic process (GO:0009071)5.12590919
27aspartate family amino acid catabolic process (GO:0009068)5.07253379
28intestinal absorption (GO:0050892)5.00504232
29phosphate ion transport (GO:0006817)4.99015228
30amino-acid betaine metabolic process (GO:0006577)4.95405348
31short-chain fatty acid metabolic process (GO:0046459)4.87122562
32sulfur amino acid catabolic process (GO:0000098)4.85240866
33response to mercury ion (GO:0046689)4.80349886
34exogenous drug catabolic process (GO:0042738)4.76726455
35positive regulation of guanylate cyclase activity (GO:0031284)4.76607009
36aromatic amino acid family metabolic process (GO:0009072)4.74979239
37glutamate metabolic process (GO:0006536)4.70845400
38cellular ketone body metabolic process (GO:0046950)4.69855199
39bile acid biosynthetic process (GO:0006699)4.68920597
40cellular modified amino acid catabolic process (GO:0042219)4.67811628
41serine family amino acid metabolic process (GO:0009069)4.63900849
422-oxoglutarate metabolic process (GO:0006103)4.61289445
43phosphate ion transmembrane transport (GO:0035435)4.59109307
44aminoglycoside antibiotic metabolic process (GO:0030647)4.56526980
45lipoprotein transport (GO:0042953)4.54542439
46fat-soluble vitamin biosynthetic process (GO:0042362)4.52557288
47indolalkylamine metabolic process (GO:0006586)4.46676407
48alpha-amino acid catabolic process (GO:1901606)4.46436313
49acetyl-CoA metabolic process (GO:0006084)4.43035607
50regulation of systemic arterial blood pressure mediated by a chemical signal (GO:0003044)4.34427203
51endocrine process (GO:0050886)4.34427203
52regulation of systemic arterial blood pressure by hormone (GO:0001990)4.34427203
53quaternary ammonium group transport (GO:0015697)4.32391333
54cellular amino acid catabolic process (GO:0009063)4.31406309
55valine metabolic process (GO:0006573)4.26551652
56amine catabolic process (GO:0009310)4.24476494
57cellular biogenic amine catabolic process (GO:0042402)4.24476494
58regulation of triglyceride catabolic process (GO:0010896)4.21143240
59benzene-containing compound metabolic process (GO:0042537)4.15927209
60urea metabolic process (GO:0019627)4.15671730
61urea cycle (GO:0000050)4.15671730
62fatty acid beta-oxidation (GO:0006635)4.14893171
63serine family amino acid biosynthetic process (GO:0009070)4.11951166
64tricarboxylic acid metabolic process (GO:0072350)4.09466639
65carnitine metabolic process (GO:0009437)4.07107362
66ketone body metabolic process (GO:1902224)4.05484433
67fatty acid oxidation (GO:0019395)4.03929493
68branched-chain amino acid metabolic process (GO:0009081)4.02671836
69fucose catabolic process (GO:0019317)4.02575057
70L-fucose metabolic process (GO:0042354)4.02575057
71L-fucose catabolic process (GO:0042355)4.02575057
72bile acid metabolic process (GO:0008206)4.01233148
73alpha-linolenic acid metabolic process (GO:0036109)4.01155138
74response to phenylpropanoid (GO:0080184)3.99277174
75lipid oxidation (GO:0034440)3.96054384
76sulfation (GO:0051923)3.93931121
77nonribosomal peptide biosynthetic process (GO:0019184)3.92455439
78vitamin D metabolic process (GO:0042359)3.90943133
79fructose metabolic process (GO:0006000)3.89810988
80nitrogen cycle metabolic process (GO:0071941)3.89789879
81regulation of cGMP biosynthetic process (GO:0030826)3.89101424
82carboxylic acid catabolic process (GO:0046395)3.85774718
83organic acid catabolic process (GO:0016054)3.85774718
84regulation of systemic arterial blood pressure (GO:0003073)3.84990853
85transepithelial transport (GO:0070633)3.84074953
86alkaloid metabolic process (GO:0009820)3.82368739
87tyrosine metabolic process (GO:0006570)3.80166902
88triglyceride-rich lipoprotein particle remodeling (GO:0034370)3.80055395
89digestion (GO:0007586)3.79325305
90cobalamin metabolic process (GO:0009235)3.78600703
91excretion (GO:0007588)3.76007787
92fatty acid catabolic process (GO:0009062)3.75065447
93cellular glucuronidation (GO:0052695)3.74064510
94glutathione biosynthetic process (GO:0006750)3.70617179
95regulation of cholesterol homeostasis (GO:2000188)3.70393738
96flavonoid metabolic process (GO:0009812)3.69871483
97monocarboxylic acid catabolic process (GO:0072329)3.68710892
98vitamin biosynthetic process (GO:0009110)3.67548164
99dicarboxylic acid biosynthetic process (GO:0043650)3.66428809
100peptide hormone processing (GO:0016486)3.65505612
101branched-chain amino acid catabolic process (GO:0009083)3.64999621
102indole-containing compound metabolic process (GO:0042430)3.62030431
103aldehyde catabolic process (GO:0046185)3.61761177
104uronic acid metabolic process (GO:0006063)3.61181827
105glucuronate metabolic process (GO:0019585)3.61181827
106receptor guanylyl cyclase signaling pathway (GO:0007168)3.61134208
107negative regulation of sterol transport (GO:0032372)3.59921114
108negative regulation of cholesterol transport (GO:0032375)3.59921114
109hormone catabolic process (GO:0042447)3.58480281
110drug metabolic process (GO:0017144)3.57512362
111amino-acid betaine transport (GO:0015838)3.56742198
112carnitine transport (GO:0015879)3.56742198
113renal absorption (GO:0070293)3.55810298
114ethanol oxidation (GO:0006069)3.55470838
115bile acid and bile salt transport (GO:0015721)3.54734956
116regulation of bile acid biosynthetic process (GO:0070857)3.53510775
117arginine metabolic process (GO:0006525)3.50918335
118positive regulation of fatty acid transport (GO:2000193)3.50588262
119glycine metabolic process (GO:0006544)3.46724593
120positive regulation of icosanoid secretion (GO:0032305)3.46724139
121coenzyme catabolic process (GO:0009109)3.46708271
1223-phosphoadenosine 5-phosphosulfate metabolic process (GO:0050427)3.44752029
123purine ribonucleoside bisphosphate metabolic process (GO:0034035)3.44752029
124regulation of cellular extravasation (GO:0002691)3.43335723
125dicarboxylic acid metabolic process (GO:0043648)3.42230589
126complement activation, alternative pathway (GO:0006957)3.40190050
127cytidine deamination (GO:0009972)3.39779055
128cytidine metabolic process (GO:0046087)3.39779055
129cytidine catabolic process (GO:0006216)3.39779055
130proline metabolic process (GO:0006560)3.35417604
131behavioral response to nicotine (GO:0035095)3.35415631
132glycine transport (GO:0015816)3.34474035
133NADH metabolic process (GO:0006734)3.33013596
134small molecule catabolic process (GO:0044282)3.31347642
135peptidyl-glutamic acid carboxylation (GO:0017187)3.31207024
136protein carboxylation (GO:0018214)3.31207024
137regulation of cGMP metabolic process (GO:0030823)3.31192319
138glutathione derivative biosynthetic process (GO:1901687)3.29630063
139glutathione derivative metabolic process (GO:1901685)3.29630063
140glycerol metabolic process (GO:0006071)3.29179732
141fat-soluble vitamin metabolic process (GO:0006775)3.26380686
142sulfate transmembrane transport (GO:1902358)3.26228911
143drinking behavior (GO:0042756)3.13993409
144vitamin transport (GO:0051180)3.13744518
145diacylglycerol metabolic process (GO:0046339)3.12925793
146virion attachment to host cell (GO:0019062)3.08013044
147adhesion of symbiont to host cell (GO:0044650)3.08013044
148auditory receptor cell differentiation (GO:0042491)3.05840196
149calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules (GO:0016338)3.01199894
150positive regulation of cGMP biosynthetic process (GO:0030828)3.00579289
151pyrimidine ribonucleoside catabolic process (GO:0046133)2.99100402
152vitamin A metabolic process (GO:0006776)2.92467903
153phosphatidylserine acyl-chain remodeling (GO:0036150)2.89158907
154renal system process involved in regulation of blood volume (GO:0001977)2.87353470
155cGMP biosynthetic process (GO:0006182)2.87175171
156quinone biosynthetic process (GO:1901663)2.85138826
157water-soluble vitamin biosynthetic process (GO:0042364)2.82539041
158proline transport (GO:0015824)2.81927092
159phosphatidylinositol acyl-chain remodeling (GO:0036149)2.81010443
160phenol-containing compound catabolic process (GO:0019336)2.78297556
161alditol metabolic process (GO:0019400)2.77393590
162phospholipase C-activating dopamine receptor signaling pathway (GO:0060158)2.76137540
163vitamin catabolic process (GO:0009111)2.69754110
164fat-soluble vitamin catabolic process (GO:0042363)2.69754110
165sulfate transport (GO:0008272)2.69036568
166glycosylceramide metabolic process (GO:0006677)2.66447286
167fucosylation (GO:0036065)2.63215203
168piRNA metabolic process (GO:0034587)2.63208487
169oxidative demethylation (GO:0070989)2.61982483
170very-low-density lipoprotein particle assembly (GO:0034379)2.59841845
171digestive system process (GO:0022600)2.58567090
172vitamin transmembrane transport (GO:0035461)2.57702791
173omega-hydroxylase P450 pathway (GO:0097267)2.56502216
174phosphate ion homeostasis (GO:0055062)2.56190122
175trivalent inorganic anion homeostasis (GO:0072506)2.56190122
176transcytosis (GO:0045056)2.55719941
177cellular response to nitric oxide (GO:0071732)2.55408741
178maintenance of gastrointestinal epithelium (GO:0030277)2.52401898
179sodium ion transport (GO:0006814)2.52185166
180antibacterial humoral response (GO:0019731)2.51585270
181positive regulation of respiratory burst (GO:0060267)2.50628062

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1RXR_22158963_ChIP-Seq_LIVER_Mouse7.38482931
2PPARA_22158963_ChIP-Seq_LIVER_Mouse6.35637084
3* LXR_22158963_ChIP-Seq_LIVER_Mouse5.71837559
4EGR1_23403033_ChIP-Seq_LIVER_Mouse5.25559099
5PPARG_19300518_ChIP-PET_3T3-L1_Mouse4.70686933
6FOXO1_23066095_ChIP-Seq_LIVER_Mouse4.02078624
7CEBPA_23403033_ChIP-Seq_LIVER_Mouse3.59861825
8NR1I2_20693526_ChIP-Seq_LIVER_Mouse3.52323296
9EZH2_22144423_ChIP-Seq_EOC_Human3.39421428
10CEBPB_23403033_ChIP-Seq_LIVER_Mouse3.12279951
11HNF4A_19761587_ChIP-ChIP_CACO-2_Human2.71340207
12TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse2.26283446
13ZNF274_21170338_ChIP-Seq_K562_Hela2.23134868
14TCF7L2_21901280_ChIP-Seq_H4IIE_Rat2.05264265
15ESR1_17901129_ChIP-ChIP_LIVER_Mouse10.1103915
16GBX2_23144817_ChIP-Seq_PC3_Human1.97969488
17ZFP57_27257070_Chip-Seq_ESCs_Mouse1.87329926
18ESR1_21235772_ChIP-Seq_MCF-7_Human1.87242249
19CLOCK_20551151_ChIP-Seq_293T_Human1.84727435
20POU3F2_20337985_ChIP-ChIP_501MEL_Human1.80002768
21GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.75907753
22CDX2_20551321_ChIP-Seq_CACO-2_Human1.73098456
23TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.72479537
24AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.70184211
25BCAT_22108803_ChIP-Seq_LS180_Human1.69007862
26FOXA2_19822575_ChIP-Seq_HepG2_Human1.68430071
27HNF4A_19822575_ChIP-Seq_HepG2_Human1.65436129
28TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.65380044
29SOX2_27498859_Chip-Seq_STOMACH_Mouse1.61462234
30CTBP1_25329375_ChIP-Seq_LNCAP_Human1.57984479
31* P300_19829295_ChIP-Seq_ESCs_Human1.56719094
32RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.56667662
33ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.54796124
34STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.53126607
35FLI1_27457419_Chip-Seq_LIVER_Mouse1.52989376
36CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.49093644
37CTBP2_25329375_ChIP-Seq_LNCAP_Human1.48598425
38NR3C1_21868756_ChIP-Seq_MCF10A_Human1.48146141
39ESR2_21235772_ChIP-Seq_MCF-7_Human1.48055760
40GATA4_25053715_ChIP-Seq_YYC3_Human1.47876949
41HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.47445677
42PCGF2_27294783_Chip-Seq_ESCs_Mouse1.46104461
43RARG_19884340_ChIP-ChIP_MEFs_Mouse1.43902486
44BMI1_23680149_ChIP-Seq_NPCS_Mouse1.38224323
45FOXA1_21572438_ChIP-Seq_LNCaP_Human1.36828835
46CBP_20019798_ChIP-Seq_JUKART_Human1.36803623
47IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.36803623
48ER_23166858_ChIP-Seq_MCF-7_Human1.36404607
49IRF1_19129219_ChIP-ChIP_H3396_Human1.33825386
50UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.33283790
51IGF1R_20145208_ChIP-Seq_DFB_Human1.32831651
52TCF4_22108803_ChIP-Seq_LS180_Human1.32590645
53SMAD4_21799915_ChIP-Seq_A2780_Human1.32158060
54TRIM28_21343339_ChIP-Seq_HEK293_Human1.30751449
55FOXA1_27270436_Chip-Seq_PROSTATE_Human1.30432602
56FOXA1_25329375_ChIP-Seq_VCAP_Human1.30432602
57PCGF2_27294783_Chip-Seq_NPCs_Mouse1.29297935
58FUS_26573619_Chip-Seq_HEK293_Human1.28828336
59EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.27290128
60NCOR_22424771_ChIP-Seq_293T_Human1.27057756
61ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.26520468
62PRDM14_20953172_ChIP-Seq_ESCs_Human1.25984321
63TOP2B_26459242_ChIP-Seq_MCF-7_Human1.24419459
64AR_25329375_ChIP-Seq_VCAP_Human1.22222245
65PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.21774615
66CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.21319361
67STAT3_23295773_ChIP-Seq_U87_Human1.20890207
68SUZ12_27294783_Chip-Seq_NPCs_Mouse1.20298606
69RXR_22108803_ChIP-Seq_LS180_Human1.20089306
70IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.20034793
71ETV2_25802403_ChIP-Seq_MESCs_Mouse1.19254696
72NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.18974838
73CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.18935474
74* TCF4_23295773_ChIP-Seq_U87_Human1.18619701
75CEBPA_26348894_ChIP-Seq_LIVER_Mouse1.18254809
76* SOX2_19829295_ChIP-Seq_ESCs_Human1.18176614
77* NANOG_19829295_ChIP-Seq_ESCs_Human1.18176614
78SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.17769311
79SMAD3_21741376_ChIP-Seq_EPCs_Human1.17414877
80NANOG_20526341_ChIP-Seq_ESCs_Human1.16930139
81PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.16539401
82NFE2_27457419_Chip-Seq_LIVER_Mouse1.15553164
83PBX1_22567123_ChIP-ChIP_OVCAR3_Human1.15117299
84DROSHA_22980978_ChIP-Seq_HELA_Human1.12561872
85SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.11931716
86KLF5_20875108_ChIP-Seq_MESCs_Mouse1.09829333
87EZH2_27294783_Chip-Seq_NPCs_Mouse1.09591448
88AR_21909140_ChIP-Seq_LNCAP_Human1.09552946
89CBX2_27304074_Chip-Seq_ESCs_Mouse1.08875376
90TP53_22573176_ChIP-Seq_HFKS_Human1.08021881
91GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.05602654
92PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.05441007
93GATA3_21878914_ChIP-Seq_MCF-7_Human1.05131182
94EWS_26573619_Chip-Seq_HEK293_Human1.04938563
95MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.04938166
96RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.04649391
97TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.04542389
98REST_21632747_ChIP-Seq_MESCs_Mouse1.04393105
99MYC_19829295_ChIP-Seq_ESCs_Human1.04357113
100BP1_19119308_ChIP-ChIP_Hs578T_Human1.03971468
101EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.03538145
102OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.02978244
103SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.02871408
104TAL1_26923725_Chip-Seq_HPCs_Mouse1.02583069
105E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.02003025
106ETV1_20927104_ChIP-Seq_GIST48_Human1.01920635
107GATA3_22897851_ChIP-Seq_JUKARTE6-1_Human1.01108770
108EED_16625203_ChIP-ChIP_MESCs_Mouse1.00953534
109SMAD4_21741376_ChIP-Seq_EPCs_Human0.99967966
110BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.99677019
111GLI1_17442700_ChIP-ChIP_MESCs_Mouse0.99466900
112CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse0.99446132
113* GATA6_25053715_ChIP-Seq_YYC3_Human0.99000791
114EGR1_19032775_ChIP-ChIP_M12_Human0.98939484
115AR_21915096_ChIP-Seq_LNCaP-1F5_Human0.97228830
116VDR_22108803_ChIP-Seq_LS180_Human0.95906847
117FOXO3_23340844_ChIP-Seq_DLD1_Human0.93074202
118LXR_22292898_ChIP-Seq_THP-1_Human0.91980555
119ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.90508524
120SOX2_20726797_ChIP-Seq_SW620_Human0.89957468
121RXRA_24833708_ChIP-Seq_LIVER_Mouse0.87464722
122SALL4_18804426_ChIP-ChIP_XEN_Mouse0.83191633
123PPAR_26484153_Chip-Seq_NCI-H1993_Human0.83154342
124THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse0.83017102
125Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse0.80815217
126STAT3_1855785_ChIP-Seq_MESCs_Mouse0.80720663
127RAD21_21589869_ChIP-Seq_MESCs_Mouse0.78090204
128GATA1_22025678_ChIP-Seq_K562_Human0.76505733
129BMI1_19503595_ChIP-Seq_MEFsC_Mouse0.76075053
130RACK7_27058665_Chip-Seq_MCF-7_Human0.74115614
131CDX2_19796622_ChIP-Seq_MESCs_Mouse0.73983451
132FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.73932910
133NRF2_20460467_ChIP-Seq_MEFs_Mouse0.72880171
134NFE2L2_20460467_ChIP-Seq_MEFs_Mouse0.72880171
135MYC_19915707_ChIP-ChIP_AK7_Human0.72663792
136EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human0.70947027
137HTT_18923047_ChIP-ChIP_STHdh_Human0.70560061
138AUTS2_25519132_ChIP-Seq_293T-REX_Human0.69760444
139* FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human0.69181391
140FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse0.68815206
141KAP1_22055183_ChIP-Seq_ESCs_Mouse0.67327368
142GATA2_19941826_ChIP-Seq_K562_Human0.67141876
143CDX2_22108803_ChIP-Seq_LS180_Human0.65364437
144NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human0.63072936
145STAT1_17558387_ChIP-Seq_HELA_Human0.62809342
146AR_20517297_ChIP-Seq_VCAP_Human0.62757647
147CEBPB_22108803_ChIP-Seq_LS180_Human0.60744830
148TAF2_19829295_ChIP-Seq_ESCs_Human0.60608446
149FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human0.60567166
150CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.60459354
151TP63_17297297_ChIP-ChIP_HaCaT_Human0.60291163
152ZNF263_19887448_ChIP-Seq_K562_Human0.60252648
153ESR1_22446102_ChIP-Seq_UTERUS_Mouse0.60099843
154SMAD2/3_21741376_ChIP-Seq_ESCs_Human0.58598434
155FOXA1_25552417_ChIP-Seq_VCAP_Human0.57862503
156TBX20_22328084_ChIP-Seq_HEART_Mouse0.57776812
157TBX20_22080862_ChIP-Seq_HEART_Mouse0.57776812
158IRF8_22096565_ChIP-ChIP_GC-B_Human0.57433378
159* SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.56797516
160PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.56131737
161P63_20808887_ChIP-Seq_KERATINOCYTES_Human0.55990551
162GATA2_20887958_ChIP-Seq_HPC-7_Mouse0.54441177
163TP63_23658742_ChIP-Seq_EP156T_Human0.53794321
164SREBP2_21459322_ChIP-Seq_LIVER_Mouse0.53446597
165SREBP1_19666523_ChIP-Seq_LIVER_Mouse0.53380660
166EBNA1_20929547_Chip-Seq_RAJI-cells_Human0.53355760
167GATA1_19941826_ChIP-Seq_K562_Human0.53111887
168* ESET_19884257_ChIP-Seq_ESCs_Mouse0.53009239
169* PIAS1_25552417_ChIP-Seq_VCAP_Human0.52964146
170ESR1_20079471_ChIP-ChIP_T-47D_Human0.52735964
171CBP_21632823_ChIP-Seq_H3396_Human0.52649201
172GATA3_20176728_ChIP-ChIP_TSCs_Mouse0.52616315
173ERG_21242973_ChIP-ChIP_JURKAT_Human0.52129252
174RARA_24833708_ChIP-Seq_LIVER_Mouse0.52031223
175TFAP2C_20629094_ChIP-Seq_MCF-7_Human0.49648490
176CREB1_26743006_Chip-Seq_LNCaP_Human0.49580136

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1* MP0005360_urolithiasis7.62970875
2MP0002139_abnormal_hepatobiliary_system7.10962741
3MP0005085_abnormal_gallbladder_physiolo4.99996982
4MP0005365_abnormal_bile_salt4.83128119
5MP0008875_abnormal_xenobiotic_pharmacok4.57217441
6* MP0005332_abnormal_amino_acid4.11171502
7MP0004019_abnormal_vitamin_homeostasis3.98808545
8MP0003195_calcinosis3.91106653
9MP0004043_abnormal_pH_regulation3.80940014
10MP0003252_abnormal_bile_duct3.77781609
11MP0003183_abnormal_peptide_metabolism3.39714567
12MP0003806_abnormal_nucleotide_metabolis3.10992967
13MP0002138_abnormal_hepatobiliary_system3.05860536
14* MP0009643_abnormal_urine_homeostasis2.82844159
15MP0001666_abnormal_nutrient_absorption2.70645796
16MP0009379_abnormal_foot_pigmentation2.40474963
17* MP0010329_abnormal_lipoprotein_level2.34216755
18MP0005636_abnormal_mineral_homeostasis2.24822640
19MP0001765_abnormal_ion_homeostasis2.17951207
20MP0001756_abnormal_urination2.11637688
21MP0003879_abnormal_hair_cell2.06299586
22MP0003191_abnormal_cellular_cholesterol2.02810765
23MP0009840_abnormal_foam_cell1.99342634
24MP0001664_abnormal_digestion1.97539800
25* MP0002136_abnormal_kidney_physiology1.81861114
26MP0005319_abnormal_enzyme/_coenzyme1.76210524
27MP0005584_abnormal_enzyme/coenzyme_acti1.75170710
28MP0001485_abnormal_pinna_reflex1.68520295
29* MP0002118_abnormal_lipid_homeostasis1.65670128
30MP0005083_abnormal_biliary_tract1.63560620
31MP0001501_abnormal_sleep_pattern1.62711343
32MP0000609_abnormal_liver_physiology1.59129681
33MP0005377_hearing/vestibular/ear_phenot1.54005314
34MP0003878_abnormal_ear_physiology1.54005314
35MP0001764_abnormal_homeostasis1.53352194
36MP0010155_abnormal_intestine_physiology1.51088356
37MP0005451_abnormal_body_composition1.48863314
38MP0003186_abnormal_redox_activity1.46926321
39MP0003646_muscle_fatigue1.43123113
40MP0002876_abnormal_thyroid_physiology1.40064776
41MP0003866_abnormal_defecation1.35359780
42MP0005084_abnormal_gallbladder_morpholo1.34724972
43MP0005551_abnormal_eye_electrophysiolog1.32423392
44MP0000678_abnormal_parathyroid_gland1.32340233
45MP0000538_abnormal_urinary_bladder1.31803537
46MP0005646_abnormal_pituitary_gland1.24413430
47MP0001873_stomach_inflammation1.23530921
48MP0003868_abnormal_feces_composition1.16012966
49MP0002102_abnormal_ear_morphology1.14138811
50MP0010386_abnormal_urinary_bladder1.13206570
51MP0004264_abnormal_extraembryonic_tissu1.11309764
52MP0005058_abnormal_lysosome_morphology1.10236746
53MP0006292_abnormal_olfactory_placode1.07759706
54MP0008877_abnormal_DNA_methylation1.06948173
55MP0006036_abnormal_mitochondrial_physio1.06326829
56MP0004270_analgesia1.06271618
57MP0010234_abnormal_vibrissa_follicle1.06138836
58MP0008961_abnormal_basal_metabolism1.03165302
59MP0001958_emphysema0.98798799
60MP0000427_abnormal_hair_cycle0.97189148
61MP0005535_abnormal_body_temperature0.96827893
62MP0008775_abnormal_heart_ventricle0.96536667
63MP0003300_gastrointestinal_ulcer0.94539050
64MP0009764_decreased_sensitivity_to0.93278393
65MP0005670_abnormal_white_adipose0.93263442
66MP0000598_abnormal_liver_morphology0.91391767
67* MP0009642_abnormal_blood_homeostasis0.91376707
68MP0002272_abnormal_nervous_system0.90638702
69MP0001986_abnormal_taste_sensitivity0.90114097
70MP0000631_abnormal_neuroendocrine_gland0.89886853
71MP0000230_abnormal_systemic_arterial0.89386511
72MP0005645_abnormal_hypothalamus_physiol0.87380328
73MP0002638_abnormal_pupillary_reflex0.87020508
74MP0002928_abnormal_bile_duct0.86776026
75MP0002837_dystrophic_cardiac_calcinosis0.84400388
76MP0002160_abnormal_reproductive_system0.82055711
77MP0004147_increased_porphyrin_level0.81485422
78MP0001661_extended_life_span0.80235604
79MP0001188_hyperpigmentation0.79962004
80MP0008469_abnormal_protein_level0.79432045
81MP0002168_other_aberrant_phenotype0.77970387
82MP0005410_abnormal_fertilization0.77829296
83MP0003705_abnormal_hypodermis_morpholog0.77517082
84MP0000604_amyloidosis0.77033483
85MP0003638_abnormal_response/metabolism_0.75913535
86MP0005220_abnormal_exocrine_pancreas0.75868866
87MP0005174_abnormal_tail_pigmentation0.73516360
88MP0002277_abnormal_respiratory_mucosa0.72995115
89MP0000026_abnormal_inner_ear0.72446862
90MP0004885_abnormal_endolymph0.72060091
91MP0003938_abnormal_ear_development0.71262657
92MP0002078_abnormal_glucose_homeostasis0.70252101
93MP0001968_abnormal_touch/_nociception0.69681525
94MP0000477_abnormal_intestine_morphology0.68765712
95* MP0002135_abnormal_kidney_morphology0.68449109
96MP0004142_abnormal_muscle_tone0.68131752
97MP0005408_hypopigmentation0.68070016
98MP0005666_abnormal_adipose_tissue0.66637463
99MP0005395_other_phenotype0.66403508
100MP0005389_reproductive_system_phenotype0.66247545
101MP0004215_abnormal_myocardial_fiber0.65703088
102MP0008789_abnormal_olfactory_epithelium0.65386483
103MP0002734_abnormal_mechanical_nocicepti0.64975410
104MP0002909_abnormal_adrenal_gland0.64608720
105MP0002796_impaired_skin_barrier0.64583468
106MP0002733_abnormal_thermal_nociception0.62372429
107MP0006276_abnormal_autonomic_nervous0.61976910
108MP0005376_homeostasis/metabolism_phenot0.61240601
109MP0001440_abnormal_grooming_behavior0.61185413
110MP0002736_abnormal_nociception_after0.60744416
111MP0003329_amyloid_beta_deposits0.60393819
112MP0004782_abnormal_surfactant_physiolog0.59321060
113MP0006035_abnormal_mitochondrial_morpho0.58372703
114MP0009765_abnormal_xenobiotic_induced0.58241084
115MP0002557_abnormal_social/conspecific_i0.58043576
116MP0001963_abnormal_hearing_physiology0.57565055
117MP0005647_abnormal_sex_gland0.56869801
118MP0005409_darkened_coat_color0.56041938
119MP0009763_increased_sensitivity_to0.54524844
120MP0002971_abnormal_brown_adipose0.54044502
121MP0003656_abnormal_erythrocyte_physiolo0.53933137
122MP0009697_abnormal_copulation0.49202496
123MP0003953_abnormal_hormone_level0.48417325
124MP0005266_abnormal_metabolism0.47160249
125MP0002089_abnormal_postnatal_growth/wei0.46398672
126MP0002896_abnormal_bone_mineralization0.45950789
127MP0003959_abnormal_lean_body0.45139028
128MP0005334_abnormal_fat_pad0.43133701
129MP0002254_reproductive_system_inflammat0.40929659
130MP0005166_decreased_susceptibility_to0.40475663
131MP0005167_abnormal_blood-brain_barrier0.40186901
132MP0003011_delayed_dark_adaptation0.39252788
133MP0003283_abnormal_digestive_organ0.36718423
134MP0009053_abnormal_anal_canal0.36637835
135MP0008872_abnormal_physiological_respon0.34832805
136MP0003724_increased_susceptibility_to0.34811026
137MP0001663_abnormal_digestive_system0.34596987
138MP0003690_abnormal_glial_cell0.34192635
139MP0002822_catalepsy0.34044133
140MP0003718_maternal_effect0.31544867
141MP0009384_cardiac_valve_regurgitation0.31482740
142MP0005448_abnormal_energy_balance0.31339487
143MP0002069_abnormal_eating/drinking_beha0.30800302
144MP0005501_abnormal_skin_physiology0.30571644
145MP0003075_altered_response_to0.29890778
146MP0002098_abnormal_vibrissa_morphology0.29184448
147MP0008873_increased_physiological_sensi0.27924400
148MP0009672_abnormal_birth_weight0.27604364
149MP0005381_digestive/alimentary_phenotyp0.27559219

Predicted human phenotypes

RankGene SetZ-score
1Gout (HP:0001997)5.88604741
2Increased circulating renin level (HP:0000848)5.49218247
3Hyperglycinuria (HP:0003108)5.45205574
4Metabolic alkalosis (HP:0200114)5.29454993
5Hypokalemic alkalosis (HP:0001949)5.26647331
6Hyperactive renin-angiotensin system (HP:0000841)5.18614892
7Hypomagnesemia (HP:0002917)4.94429730
8* Abnormality of glutamine family amino acid metabolism (HP:0010902)4.87986521
9Abnormality of aromatic amino acid family metabolism (HP:0004338)4.77748793
10Abnormality of serine family amino acid metabolism (HP:0010894)4.76341233
11Abnormality of glycine metabolism (HP:0010895)4.76341233
12Abnormality of chloride homeostasis (HP:0011422)4.55066686
13Abnormal urine output (HP:0012590)4.54429866
14Polyuria (HP:0000103)4.53724530
15Proximal tubulopathy (HP:0000114)4.53715275
16Abnormality of purine metabolism (HP:0004352)4.44194143
17Increased purine levels (HP:0004368)4.41321402
18Hyperuricemia (HP:0002149)4.41321402
19Abnormality of the vitamin B12 metabolism (HP:0004341)4.35576517
20Intrahepatic cholestasis (HP:0001406)4.30219788
21Alkalosis (HP:0001948)4.27221681
22Ketosis (HP:0001946)4.25887553
23Abnormality of vitamin B metabolism (HP:0004340)4.25746044
24Abnormality of magnesium homeostasis (HP:0004921)4.22735020
25Abnormality of renal excretion (HP:0011036)4.20718634
26Ketoacidosis (HP:0001993)4.18425497
27Xanthomatosis (HP:0000991)3.96430345
28Abnormality of monocarboxylic acid metabolism (HP:0010996)3.92823568
29Hyperglycinemia (HP:0002154)3.91857442
30Hyperammonemia (HP:0001987)3.84562521
31Congenital sensorineural hearing impairment (HP:0008527)3.83154460
32Abnormality of nucleobase metabolism (HP:0010932)3.75076269
33Decreased circulating renin level (HP:0003351)3.71541532
34Abnormality of fatty-acid metabolism (HP:0004359)3.69681711
35Polydipsia (HP:0001959)3.57762162
36Abnormal drinking behavior (HP:0030082)3.57762162
37Chronic diarrhea (HP:0002028)3.55240410
38Tetany (HP:0001281)3.54396109
39Generalized aminoaciduria (HP:0002909)3.48331854
40Deep venous thrombosis (HP:0002625)3.44972505
41Abnormality of renin-angiotensin system (HP:0000847)3.37341689
42Hyperaldosteronism (HP:0000859)3.37030988
43Renal salt wasting (HP:0000127)3.34898620
44Delayed CNS myelination (HP:0002188)3.34894788
45* Abnormality of aspartate family amino acid metabolism (HP:0010899)3.31714538
46Glycosuria (HP:0003076)3.31341143
47Abnormality of urine glucose concentration (HP:0011016)3.31341143
48Hydroxyprolinuria (HP:0003080)3.29757509
49Abnormality of proline metabolism (HP:0010907)3.29757509
50Pigmentary retinal degeneration (HP:0001146)3.26246470
51Hypobetalipoproteinemia (HP:0003563)3.24617179
52Abnormality of vitamin metabolism (HP:0100508)3.16225234
53* Abnormality of sulfur amino acid metabolism (HP:0004339)3.04499529
54Metabolic acidosis (HP:0001942)3.01747484
55Malnutrition (HP:0004395)2.93331102
56Renal tubular acidosis (HP:0001947)2.91274222
57Vascular calcification (HP:0004934)2.89856247
58Fat malabsorption (HP:0002630)2.82696743
59Dicarboxylic aciduria (HP:0003215)2.79933288
60Abnormality of dicarboxylic acid metabolism (HP:0010995)2.79933288
61Hypoglycemic coma (HP:0001325)2.76415397
62Prolonged partial thromboplastin time (HP:0003645)2.74558435
63Hyperphosphaturia (HP:0003109)2.72518211
64Chorioretinal atrophy (HP:0000533)2.69635579
65Complement deficiency (HP:0004431)2.65255385
66Hypercalciuria (HP:0002150)2.65072535
67Ileus (HP:0002595)2.64288673
68Lethargy (HP:0001254)2.62055652
69Vomiting (HP:0002013)2.59423291
70Rickets (HP:0002748)2.58086521
71Cardiovascular calcification (HP:0011915)2.56653253
72Joint hemorrhage (HP:0005261)2.54546138
73Conjugated hyperbilirubinemia (HP:0002908)2.53605906
74Enlarged kidneys (HP:0000105)2.53071207
75Hypokalemia (HP:0002900)2.52909807
76* Nephrolithiasis (HP:0000787)2.51241703
77Abnormality of serum amino acid levels (HP:0003112)2.48953372
78Abnormal urine phosphate concentration (HP:0012599)2.46251719
79Hyperlipoproteinemia (HP:0010980)2.42769913
80Confusion (HP:0001289)2.40964671
81Abnormality of the renal cortex (HP:0011035)2.38427487
82Tubular atrophy (HP:0000092)2.37490726
83Abnormality of pyrimidine metabolism (HP:0004353)2.36840521
84Epidermoid cyst (HP:0200040)2.36798172
85Hypolipoproteinemia (HP:0010981)2.34045264
86Pancreatic cysts (HP:0001737)2.33167802
87Hypophosphatemia (HP:0002148)2.32418398
88Hypothermia (HP:0002045)2.30275997
89Irritability (HP:0000737)2.30127933
90Enlarged epiphyses (HP:0010580)2.28406649
91Hepatocellular carcinoma (HP:0001402)2.26864017
92Widely patent fontanelles and sutures (HP:0004492)2.24787654
93Abnormal enzyme/coenzyme activity (HP:0012379)2.24696403
94Methylmalonic aciduria (HP:0012120)2.22222324
95Abnormality of long-chain fatty-acid metabolism (HP:0010964)2.21475443
96Abnormality of methionine metabolism (HP:0010901)2.21110351
97Megaloblastic anemia (HP:0001889)2.20585815
98Abnormality of the common coagulation pathway (HP:0010990)2.20011644
99Hyperbilirubinemia (HP:0002904)2.19315975
100Dehydration (HP:0001944)2.19052068
101Nephrocalcinosis (HP:0000121)2.18880971
102Potter facies (HP:0002009)2.15926646
103Facial shape deformation (HP:0011334)2.15926646
104Neonatal onset (HP:0003623)2.15436920
105Congenital stationary night blindness (HP:0007642)2.15257055
106Abnormality of potassium homeostasis (HP:0011042)2.13468922
107Sensorimotor neuropathy (HP:0007141)2.12424258
108Abnormality of alkaline phosphatase activity (HP:0004379)2.09244176
109Acanthocytosis (HP:0001927)2.09171682
110Abnormality of the level of lipoprotein cholesterol (HP:0010979)2.07974556
111Molar tooth sign on MRI (HP:0002419)2.05948095
112Abnormality of midbrain morphology (HP:0002418)2.05948095
113Abnormal albumin level (HP:0012116)2.04682012
114Hypoalbuminemia (HP:0003073)2.04682012
115Late onset (HP:0003584)2.04543458
116Spastic diplegia (HP:0001264)2.04464094
117Abolished electroretinogram (ERG) (HP:0000550)2.03946589
118Renal cortical cysts (HP:0000803)2.00938191
119Abnormal tarsal ossification (HP:0008369)1.99207637
120Nausea (HP:0002018)1.98213486
121Cerebral edema (HP:0002181)1.97684199
122Abnormality of macular pigmentation (HP:0008002)1.95097590
123Steatorrhea (HP:0002570)1.94346885
124Abnormality of the renal medulla (HP:0100957)1.92085590
125Vacuolated lymphocytes (HP:0001922)1.91093391
126Decreased central vision (HP:0007663)1.89426205
127Delayed epiphyseal ossification (HP:0002663)1.88600362
128Posterior subcapsular cataract (HP:0007787)1.88308488
129Pendular nystagmus (HP:0012043)1.86795596
130Aplasia/Hypoplasia of the tibia (HP:0005772)1.84082207
131Adrenal overactivity (HP:0002717)1.82726536
132Hyperventilation (HP:0002883)1.82246362
133Hypophosphatemic rickets (HP:0004912)1.81442081
134Abnormality of the costochondral junction (HP:0000919)1.80304543
135Pancreatic fibrosis (HP:0100732)1.77957231
136Attenuation of retinal blood vessels (HP:0007843)1.76276249
137Focal segmental glomerulosclerosis (HP:0000097)1.75782346
138True hermaphroditism (HP:0010459)1.73787849
139Short tibia (HP:0005736)1.72413106
140Hypotension (HP:0002615)1.68610030
141Stomach cancer (HP:0012126)1.67109030
142Hypoplasia of the uterus (HP:0000013)1.64746595
143Abnormal rod and cone electroretinograms (HP:0008323)1.64150617

Predicted kinase interactions (KEA)

RankGene SetZ-score
1WNK37.81882767
2WNK46.82241993
3OXSR16.37082113
4ACVR1B5.43500166
5BCKDK4.43623565
6STK393.12455702
7ADRBK22.60329690
8FGFR42.37339095
9TLK12.31658024
10STK38L2.23923430
11MST1R2.23855957
12ERN12.14897625
13BMPR1B1.94208022
14MAP4K21.79577523
15PIK3CA1.75843434
16CASK1.69794764
17FRK1.68456388
18NUAK11.67031780
19SGK4941.63429446
20SGK2231.63429446
21PDK31.62411816
22PDK41.62411816
23INSRR1.49926840
24TNIK1.46811457
25GRK61.43207749
26NEK11.40349258
27ERBB41.37242537
28TXK1.36283883
29SIK11.33545560
30PDK21.22583369
31ZAK1.19591565
32WNK11.17419792
33MST41.16525487
34MAPK111.15134434
35MAP3K91.14808890
36SGK31.09780370
37MAPK131.09029922
38PTK61.07674909
39MAP3K71.06675723
40SGK21.06178084
41EPHB10.93958628
42RIPK10.93695583
43PINK10.93101479
44EPHA30.90194092
45STK380.89923917
46MAP3K40.88618132
47TAOK30.86725218
48LATS10.85802627
49MAP2K40.83436879
50PRKAA20.82265773
51GSK3A0.79230372
52ABL20.78690061
53MET0.77797065
54MAP3K120.76800397
55PRKAA10.75933871
56PTK20.74104894
57MAP3K30.73838206
58NLK0.73617394
59PRKCE0.73598414
60ADRBK10.73383491
61MAPKAPK30.73118610
62CDK190.68295894
63TEC0.66450852
64STK240.66159117
65DYRK1B0.65941737
66EPHA20.65781672
67NTRK30.65543873
68KIT0.65041688
69LRRK20.64769274
70AKT30.64611383
71TIE10.64002245
72TRIB30.63037407
73NME10.60515839
74MATK0.57787442
75CAMK2A0.57261989
76PRKCZ0.56873115
77JAK20.56571157
78PDPK10.56537150
79MAP3K140.55153357
80TRIM280.54337792
81CAMKK20.53296746
82GRK70.52881478
83BCR0.52575520
84PRKCG0.52078785
85TYK20.50592107
86CSNK1A10.50366881
87PIK3CG0.50291103
88ITK0.48703738
89PIM10.48603352
90MAP3K100.47288238
91MAP3K20.46898103
92ERBB20.46848745
93MAP3K110.46200321
94PKN20.46019249
95PRKACG0.44750977
96PRKG10.44420114
97TGFBR20.43388757
98IKBKB0.42925767
99GRK50.42799504
100MAPK150.42710962
101STK30.42655612
102PAK30.42277900
103CSNK1G10.41867635
104SGK10.41303742
105MAP4K10.41000017
106MAP2K30.40860656
107FER0.40291518
108NEK90.40161006
109DAPK20.38193762
110MAP3K130.36250214
111PRKG20.35735893
112MUSK0.35608141
113IRAK30.35391013
114MAP2K70.35149143
115PDK10.33913663
116MYLK0.33540248
117MAP2K20.31964293
118NEK60.31390776
119CSNK1G20.30785043
120MAPK40.30639191
121OBSCN0.30410372
122CSNK1G30.30045462
123SYK0.29798828
124KDR0.28966476
125BRSK20.28963002
126TBK10.28247575
127PRKCI0.26633429
128MAP2K60.24506479
129LMTK20.24467538
130BMX0.24460077
131FGFR20.23987915
132STK100.23925931
133MAPK120.23659436
134PRKCA0.23489037
135PRKCD0.23446958
136CAMK2G0.23417685
137CSK0.22302136
138PRKCQ0.22121623
139IRAK20.20879717
140JAK10.18726933
141FLT30.18679168
142MAP2K10.17104317
143PAK40.16849518
144AKT20.15662941
145IGF1R0.15416601
146EPHA40.15357458
147IRAK10.14074677
148EPHB20.14017368
149PRKACA0.13392096
150PTK2B0.12370778
151STK110.12258832
152GRK10.09992733
153CDK60.09614920

Predicted pathways (KEGG)

RankGene SetZ-score
1Ascorbate and aldarate metabolism_Homo sapiens_hsa000533.37462748
2Primary bile acid biosynthesis_Homo sapiens_hsa001203.03976428
3Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006303.02522639
4Butanoate metabolism_Homo sapiens_hsa006502.96029825
5Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.86307303
6Tryptophan metabolism_Homo sapiens_hsa003802.72940879
7Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004002.66509825
8Nitrogen metabolism_Homo sapiens_hsa009102.61496517
9Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.60838518
10Propanoate metabolism_Homo sapiens_hsa006402.55395522
11Fatty acid degradation_Homo sapiens_hsa000712.53995680
12Pentose and glucuronate interconversions_Homo sapiens_hsa000402.53838793
132-Oxocarboxylic acid metabolism_Homo sapiens_hsa012102.50151447
14Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006012.45413299
15Arginine biosynthesis_Homo sapiens_hsa002202.43891876
16Cyanoamino acid metabolism_Homo sapiens_hsa004602.39201374
17Peroxisome_Homo sapiens_hsa041462.37794785
18Glycine, serine and threonine metabolism_Homo sapiens_hsa002602.30861261
19Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049642.27407573
20Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010402.15241220
21Vitamin digestion and absorption_Homo sapiens_hsa049771.97335198
22Bile secretion_Homo sapiens_hsa049761.91353761
23beta-Alanine metabolism_Homo sapiens_hsa004101.89863140
24Pyruvate metabolism_Homo sapiens_hsa006201.88774366
25Fatty acid metabolism_Homo sapiens_hsa012121.82161457
26Sulfur metabolism_Homo sapiens_hsa009201.76538619
27PPAR signaling pathway_Homo sapiens_hsa033201.76372076
28Histidine metabolism_Homo sapiens_hsa003401.66297515
29Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.64088151
30Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.62279649
31Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.61154567
32Ether lipid metabolism_Homo sapiens_hsa005651.52789688
33Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.50221031
34Complement and coagulation cascades_Homo sapiens_hsa046101.48864812
35Carbon metabolism_Homo sapiens_hsa012001.46747745
36Selenocompound metabolism_Homo sapiens_hsa004501.41629422
37Intestinal immune network for IgA production_Homo sapiens_hsa046721.40687659
38Starch and sucrose metabolism_Homo sapiens_hsa005001.40146751
39Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.39800248
40Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.39704406
41Chemical carcinogenesis_Homo sapiens_hsa052041.36104948
42Steroid hormone biosynthesis_Homo sapiens_hsa001401.33377021
43Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.32532968
44Phenylalanine metabolism_Homo sapiens_hsa003601.25820523
45Glutathione metabolism_Homo sapiens_hsa004801.25508143
46Folate biosynthesis_Homo sapiens_hsa007901.25139525
47Drug metabolism - other enzymes_Homo sapiens_hsa009831.24069353
48Arginine and proline metabolism_Homo sapiens_hsa003301.22952521
49Asthma_Homo sapiens_hsa053101.22593972
50Biosynthesis of amino acids_Homo sapiens_hsa012301.21435533
51Retinol metabolism_Homo sapiens_hsa008301.12908507
52Lysine degradation_Homo sapiens_hsa003101.12277109
53Caffeine metabolism_Homo sapiens_hsa002321.08386450
54Cysteine and methionine metabolism_Homo sapiens_hsa002701.08273287
55Fat digestion and absorption_Homo sapiens_hsa049751.07582088
56Fatty acid elongation_Homo sapiens_hsa000621.05349178
57Maturity onset diabetes of the young_Homo sapiens_hsa049501.01338208
58Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.97356813
59Tyrosine metabolism_Homo sapiens_hsa003500.93643158
60Phototransduction_Homo sapiens_hsa047440.93034335
61Glycerolipid metabolism_Homo sapiens_hsa005610.89884716
62Allograft rejection_Homo sapiens_hsa053300.88075239
63ABC transporters_Homo sapiens_hsa020100.86965938
64Autoimmune thyroid disease_Homo sapiens_hsa053200.82703383
65Steroid biosynthesis_Homo sapiens_hsa001000.82193721
66Mineral absorption_Homo sapiens_hsa049780.81420064
67Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.76301522
68Renin-angiotensin system_Homo sapiens_hsa046140.74735354
69Staphylococcus aureus infection_Homo sapiens_hsa051500.73991035
70Type I diabetes mellitus_Homo sapiens_hsa049400.73836883
71Pancreatic secretion_Homo sapiens_hsa049720.73101238
72Graft-versus-host disease_Homo sapiens_hsa053320.72261095
73Fructose and mannose metabolism_Homo sapiens_hsa000510.71490539
74Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.70868307
75Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.69802071
76Insulin secretion_Homo sapiens_hsa049110.65525504
77Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.64596607
78Sulfur relay system_Homo sapiens_hsa041220.63169618
79Pentose phosphate pathway_Homo sapiens_hsa000300.61796032
80Collecting duct acid secretion_Homo sapiens_hsa049660.60454955
81Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.57825175
82* Protein digestion and absorption_Homo sapiens_hsa049740.55443663
83Nicotine addiction_Homo sapiens_hsa050330.54811507
84Serotonergic synapse_Homo sapiens_hsa047260.54804423
85Metabolic pathways_Homo sapiens_hsa011000.54005475
86Ovarian steroidogenesis_Homo sapiens_hsa049130.52903702
87Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.47314178
88Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.45480055
89Renin secretion_Homo sapiens_hsa049240.43389836
90Carbohydrate digestion and absorption_Homo sapiens_hsa049730.42345082
91Galactose metabolism_Homo sapiens_hsa000520.40155706
92Other glycan degradation_Homo sapiens_hsa005110.39557441
93Taste transduction_Homo sapiens_hsa047420.37779480
94Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.36472131
95Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.35818920
96Cocaine addiction_Homo sapiens_hsa050300.35498110
97Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.34111706
98Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.31573492
99Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.31557724
100Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.30516656
101Vitamin B6 metabolism_Homo sapiens_hsa007500.28309457
102One carbon pool by folate_Homo sapiens_hsa006700.27104826
103Salivary secretion_Homo sapiens_hsa049700.25066202
104Olfactory transduction_Homo sapiens_hsa047400.24722452
105Thyroid hormone synthesis_Homo sapiens_hsa049180.22544929
106Dorso-ventral axis formation_Homo sapiens_hsa043200.22283181
107Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.22163824
108Gastric acid secretion_Homo sapiens_hsa049710.20003298
109Cardiac muscle contraction_Homo sapiens_hsa042600.17412986
110Insulin resistance_Homo sapiens_hsa049310.16862511
111Amphetamine addiction_Homo sapiens_hsa050310.15728539
112alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.14555806
113Morphine addiction_Homo sapiens_hsa050320.13372952
114Adipocytokine signaling pathway_Homo sapiens_hsa049200.12931855
115Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.12322829
116Vascular smooth muscle contraction_Homo sapiens_hsa042700.12192134
117Alzheimers disease_Homo sapiens_hsa050100.11584320
118Lysosome_Homo sapiens_hsa041420.10235401
119Oxidative phosphorylation_Homo sapiens_hsa001900.09950637
120Glycosaminoglycan degradation_Homo sapiens_hsa005310.09761699
121Fatty acid biosynthesis_Homo sapiens_hsa000610.07561864
122Arachidonic acid metabolism_Homo sapiens_hsa005900.06982671
123Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.03938627
124Glycerophospholipid metabolism_Homo sapiens_hsa005640.02789101
125Bladder cancer_Homo sapiens_hsa05219-0.1204511
126Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa00520-0.1203603
127Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604-0.1145386
128Linoleic acid metabolism_Homo sapiens_hsa00591-0.1098886
129Sphingolipid metabolism_Homo sapiens_hsa00600-0.1015020
130Hepatitis C_Homo sapiens_hsa05160-0.0821033
131Prion diseases_Homo sapiens_hsa05020-0.0760042
132Parkinsons disease_Homo sapiens_hsa05012-0.0741828
133AMPK signaling pathway_Homo sapiens_hsa04152-0.0130258
134Glucagon signaling pathway_Homo sapiens_hsa04922-0.0066248

Most similar genes based on co-expression Upload to Enrichr

Tissue Expression Export image »

Cell Line Expression Export image »