SLC40A1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene is a cell membrane protein that may be involved in iron export from duodenal epithelial cells. Defects in this gene are a cause of hemochromatosis type 4 (HFE4). NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1L-phenylalanine catabolic process (GO:0006559)6.65559536
2erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)6.65559536
3L-phenylalanine metabolic process (GO:0006558)6.30101648
4erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)6.30101648
5aromatic amino acid family catabolic process (GO:0009074)5.98067710
6triglyceride-rich lipoprotein particle remodeling (GO:0034370)5.96195253
7indole-containing compound catabolic process (GO:0042436)5.40875764
8indolalkylamine catabolic process (GO:0046218)5.40875764
9tryptophan catabolic process (GO:0006569)5.40875764
10high-density lipoprotein particle remodeling (GO:0034375)5.30883847
11tryptophan metabolic process (GO:0006568)5.25601979
12urea metabolic process (GO:0019627)5.24941112
13urea cycle (GO:0000050)5.24941112
14kynurenine metabolic process (GO:0070189)5.21786431
15bile acid biosynthetic process (GO:0006699)5.12547333
16glyoxylate metabolic process (GO:0046487)5.06226729
17protein carboxylation (GO:0018214)5.05475504
18peptidyl-glutamic acid carboxylation (GO:0017187)5.05475504
19complement activation, alternative pathway (GO:0006957)5.04488381
20regulation of protein activation cascade (GO:2000257)5.00684733
21alpha-linolenic acid metabolic process (GO:0036109)5.00340594
22negative regulation of fibrinolysis (GO:0051918)4.98473662
23reverse cholesterol transport (GO:0043691)4.98074943
24phospholipid efflux (GO:0033700)4.92623314
25regulation of fibrinolysis (GO:0051917)4.85971460
26sulfur amino acid catabolic process (GO:0000098)4.80152498
27nitrogen cycle metabolic process (GO:0071941)4.79431485
28cysteine metabolic process (GO:0006534)4.71707810
29regulation of complement activation (GO:0030449)4.70635065
30fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)4.68297965
31regulation of triglyceride catabolic process (GO:0010896)4.66871330
32glucocorticoid biosynthetic process (GO:0006704)4.66782629
33regulation of cholesterol esterification (GO:0010872)4.65836476
34plasma lipoprotein particle remodeling (GO:0034369)4.60926545
35protein-lipid complex remodeling (GO:0034368)4.60926545
36macromolecular complex remodeling (GO:0034367)4.60926545
37bile acid metabolic process (GO:0008206)4.51442211
38homocysteine metabolic process (GO:0050667)4.45326959
39acylglycerol homeostasis (GO:0055090)4.43889084
40triglyceride homeostasis (GO:0070328)4.43889084
41plasma lipoprotein particle assembly (GO:0034377)4.38798838
42plasma lipoprotein particle clearance (GO:0034381)4.37577691
43cholesterol efflux (GO:0033344)4.36038943
44serine family amino acid catabolic process (GO:0009071)4.34571832
45bile acid and bile salt transport (GO:0015721)4.31586530
46aromatic amino acid family metabolic process (GO:0009072)4.30312538
47tyrosine metabolic process (GO:0006570)4.24194757
48phospholipid homeostasis (GO:0055091)4.21336167
49thrombin receptor signaling pathway (GO:0070493)4.20697092
50amino-acid betaine metabolic process (GO:0006577)4.20638559
51lysine metabolic process (GO:0006553)4.17084165
52lysine catabolic process (GO:0006554)4.17084165
53negative regulation of cholesterol transport (GO:0032375)4.11528138
54negative regulation of sterol transport (GO:0032372)4.11528138
55positive regulation of triglyceride lipase activity (GO:0061365)3.98450514
56positive regulation of lipoprotein lipase activity (GO:0051006)3.98450514
57alpha-amino acid catabolic process (GO:1901606)3.95395982
58low-density lipoprotein particle remodeling (GO:0034374)3.93045538
59cellular biogenic amine catabolic process (GO:0042402)3.92543250
60amine catabolic process (GO:0009310)3.92543250
61protein-lipid complex assembly (GO:0065005)3.92486494
62epoxygenase P450 pathway (GO:0019373)3.91088141
63indolalkylamine metabolic process (GO:0006586)3.90111701
64imidazole-containing compound metabolic process (GO:0052803)3.88028607
65cellular ketone body metabolic process (GO:0046950)3.83595210
66plasma lipoprotein particle organization (GO:0071827)3.82144491
67fibrinolysis (GO:0042730)3.81981879
68exogenous drug catabolic process (GO:0042738)3.79202876
69cellular glucuronidation (GO:0052695)3.76308560
70regulation of cholesterol homeostasis (GO:2000188)3.75284806
71cholesterol homeostasis (GO:0042632)3.75070365
72very-low-density lipoprotein particle assembly (GO:0034379)3.73320393
73sterol homeostasis (GO:0055092)3.69226586
74lipoprotein metabolic process (GO:0042157)3.68940117
75glucocorticoid metabolic process (GO:0008211)3.66317319
76drug catabolic process (GO:0042737)3.66066842
77glutamate metabolic process (GO:0006536)3.64841833
78angiotensin maturation (GO:0002003)3.64257132
79cellular amino acid catabolic process (GO:0009063)3.63565647
80aldehyde catabolic process (GO:0046185)3.62488052
81benzene-containing compound metabolic process (GO:0042537)3.62098731
82complement activation (GO:0006956)3.61919060
83protein activation cascade (GO:0072376)3.60271553
84complement activation, classical pathway (GO:0006958)3.59803683
85protein-lipid complex subunit organization (GO:0071825)3.58908571
86blood coagulation, intrinsic pathway (GO:0007597)3.58620590
87positive regulation of lipid catabolic process (GO:0050996)3.56960794
88arginine metabolic process (GO:0006525)3.56188965
89dicarboxylic acid biosynthetic process (GO:0043650)3.55300119
90negative regulation of lipase activity (GO:0060192)3.54107699
91cellular modified amino acid catabolic process (GO:0042219)3.52458434
92androgen biosynthetic process (GO:0006702)3.46379282
93glucuronate metabolic process (GO:0019585)3.43341768
94uronic acid metabolic process (GO:0006063)3.43341768
95progesterone metabolic process (GO:0042448)3.43254386
96regulation of bile acid biosynthetic process (GO:0070857)3.41913990
97cofactor catabolic process (GO:0051187)3.41739650
98definitive hemopoiesis (GO:0060216)3.40837650
99glycine metabolic process (GO:0006544)3.38885088
100serine family amino acid metabolic process (GO:0009069)3.36702230
101regulation of systemic arterial blood pressure by renin-angiotensin (GO:0003081)3.33765979
102ethanol oxidation (GO:0006069)3.32817882
103coenzyme catabolic process (GO:0009109)3.32382461
104drug transmembrane transport (GO:0006855)3.31648597
105acute-phase response (GO:0006953)3.31220935
106response to nitrosative stress (GO:0051409)3.30183491
107intestinal cholesterol absorption (GO:0030299)3.29080828
108ketone body metabolic process (GO:1902224)3.28611692
109carboxylic acid catabolic process (GO:0046395)3.27932155
110organic acid catabolic process (GO:0016054)3.27932155
111hormone catabolic process (GO:0042447)3.27751274
112neutrophil activation involved in immune response (GO:0002283)3.18518525
113negative regulation of protein activation cascade (GO:2000258)3.17382919
114intestinal absorption (GO:0050892)3.13825775
115peptide catabolic process (GO:0043171)3.11998847
116negative regulation of complement activation (GO:0045916)3.09298157
117drug metabolic process (GO:0017144)3.07388951
118ethanol metabolic process (GO:0006067)3.04052311
119daunorubicin metabolic process (GO:0044597)3.02481633
120polyketide metabolic process (GO:0030638)3.02481633
121doxorubicin metabolic process (GO:0044598)3.02481633
122negative regulation of erythrocyte differentiation (GO:0045647)2.98240265
123C21-steroid hormone metabolic process (GO:0008207)2.93349998
124negative regulation of blood coagulation (GO:0030195)2.85074494
125negative regulation of hemostasis (GO:1900047)2.85074494
126fat-soluble vitamin biosynthetic process (GO:0042362)2.83555993
127hemoglobin metabolic process (GO:0020027)2.77944087
128cyclooxygenase pathway (GO:0019371)2.77813561
129positive regulation of hemostasis (GO:1900048)2.75614409
130positive regulation of blood coagulation (GO:0030194)2.75614409
131aminoglycoside antibiotic metabolic process (GO:0030647)2.71091749
132regulation of humoral immune response (GO:0002920)2.67551366
133C21-steroid hormone biosynthetic process (GO:0006700)2.67097479
134negative regulation of humoral immune response (GO:0002921)2.64387566
135positive regulation of coagulation (GO:0050820)2.62063484
136androgen metabolic process (GO:0008209)2.61535462
137protoporphyrinogen IX metabolic process (GO:0046501)2.61098266
138antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G2.58862579
139negative regulation of coagulation (GO:0050819)2.58545050
140leukotriene metabolic process (GO:0006691)2.58409747
141regulation of platelet activation (GO:0010543)2.58183513
142alkaloid metabolic process (GO:0009820)2.53357049
143antibacterial humoral response (GO:0019731)2.52953953
144regulation of hemostasis (GO:1900046)2.49848325
145regulation of blood coagulation (GO:0030193)2.49848325
146lipoprotein transport (GO:0042953)2.48330390
147positive regulation of systemic arterial blood pressure (GO:0003084)2.47934991
148flavonoid metabolic process (GO:0009812)2.46369573
149regulation of systemic arterial blood pressure by hormone (GO:0001990)2.45736281
150regulation of systemic arterial blood pressure mediated by a chemical signal (GO:0003044)2.45736281
151endocrine process (GO:0050886)2.45736281
152positive regulation of steroid metabolic process (GO:0045940)2.45534795
153phenylpropanoid metabolic process (GO:0009698)2.44328204
154positive regulation of fatty acid biosynthetic process (GO:0045723)2.43690076
155arginine catabolic process (GO:0006527)2.42883810
156xenobiotic metabolic process (GO:0006805)2.42360068

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1* RXR_22158963_ChIP-Seq_LIVER_Mouse7.47164818
2PPARA_22158963_ChIP-Seq_LIVER_Mouse6.52514805
3EGR1_23403033_ChIP-Seq_LIVER_Mouse6.36547175
4LXR_22158963_ChIP-Seq_LIVER_Mouse6.06954603
5CEBPA_23403033_ChIP-Seq_LIVER_Mouse4.61192713
6FOXO1_23066095_ChIP-Seq_LIVER_Mouse4.60332433
7PPARG_19300518_ChIP-PET_3T3-L1_Mouse4.11315345
8NR1I2_20693526_ChIP-Seq_LIVER_Mouse3.65932044
9CEBPB_23403033_ChIP-Seq_LIVER_Mouse3.56978262
10HNF4A_19761587_ChIP-ChIP_CACO-2_Human2.15609529
11IRF8_22096565_ChIP-ChIP_GC-B_Human2.10803016
12SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human2.10150907
13MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.08773763
14* ESR1_17901129_ChIP-ChIP_LIVER_Mouse10.5174314
15* GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.98926402
16GATA1_22025678_ChIP-Seq_K562_Human1.98235660
17CLOCK_20551151_ChIP-Seq_293T_Human1.87058890
18TCF7L2_21901280_ChIP-Seq_H4IIE_Rat1.85605883
19STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.82276675
20TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.81136082
21FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.80899673
22STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.74416096
23TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.69307367
24* Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.66452199
25IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.66256999
26FOXA2_19822575_ChIP-Seq_HepG2_Human1.65607789
27SPI1_23127762_ChIP-Seq_K562_Human1.51918484
28* HNF4A_19822575_ChIP-Seq_HepG2_Human1.30982708
29SOX2_27498859_Chip-Seq_STOMACH_Mouse1.28225752
30IRF8_27001747_Chip-Seq_BMDM_Mouse1.26590228
31RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.25392883
32* SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.24637839
33STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.23453223
34THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.22119301
35FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.19748417
36NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.19352620
37SALL4_18804426_ChIP-ChIP_XEN_Mouse1.15899861
38RUNX_20019798_ChIP-Seq_JUKART_Human1.15623685
39* GATA4_25053715_ChIP-Seq_YYC3_Human1.14544749
40* NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.13296184
41RARG_19884340_ChIP-ChIP_MEFs_Mouse1.12543713
42ESR1_15608294_ChIP-ChIP_MCF-7_Human1.10617197
43IRF8_21731497_ChIP-ChIP_J774_Mouse1.10184179
44RUNX1_22412390_ChIP-Seq_EML_Mouse1.09870266
45ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.09437251
46ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.08487088
47FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.07165720
48* GATA1_19941826_ChIP-Seq_K562_Human1.07022881
49HTT_18923047_ChIP-ChIP_STHdh_Human1.05649503
50CDX2_20551321_ChIP-Seq_CACO-2_Human1.00982716
51BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.00607657
52GATA2_21666600_ChIP-Seq_HMVEC_Human0.99921706
53STAT6_20620947_ChIP-Seq_CD4_POS_T_Human0.99058464
54ESR1_21235772_ChIP-Seq_MCF-7_Human0.97554313
55CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.95696762
56PBX1_22567123_ChIP-ChIP_OVCAR3_Human0.95309216
57PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse0.93949257
58VDR_24763502_ChIP-Seq_THP-1_Human0.92999969
59KLF1_20508144_ChIP-Seq_FETAL-LIVER-ERYTHROID_Mouse0.92548285
60BP1_19119308_ChIP-ChIP_Hs578T_Human0.91256441
61RXRA_24833708_ChIP-Seq_LIVER_Mouse0.90041946
62CDX2_22108803_ChIP-Seq_LS180_Human0.89807722
63* GATA2_19941826_ChIP-Seq_K562_Human0.88678820
64BRD4_27068464_Chip-Seq_AML-cells_Mouse0.87344492
65PPAR_26484153_Chip-Seq_NCI-H1993_Human0.86998549
66IRF8_22096565_ChIP-ChIP_GC-B_Mouse0.86467088
67FOXO3_23340844_ChIP-Seq_DLD1_Human0.86334943
68GATA1_19941827_ChIP-Seq_MEL86_Mouse0.86312508
69ESR1_20079471_ChIP-ChIP_T-47D_Human0.86150327
70* SOX2_20726797_ChIP-Seq_SW620_Human0.85619776
71* NFE2L2_20460467_ChIP-Seq_MEFs_Mouse0.85355176
72* NRF2_20460467_ChIP-Seq_MEFs_Mouse0.85355176
73SMAD_19615063_ChIP-ChIP_OVARY_Human0.85161354
74PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.83887144
75GATA1_19941827_ChIP-Seq_MEL_Mouse0.83020182
76* ZNF217_24962896_ChIP-Seq_MCF-7_Human0.81617462
77MYB_21317192_ChIP-Seq_ERMYB_Mouse0.81431645
78E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human0.81299623
79FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.80851217
80EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human0.80500391
81* AR_21915096_ChIP-Seq_LNCaP-1F5_Human0.80425062
82MEIS1_20887958_ChIP-Seq_HPC-7_Mouse0.79882595
83SPI1_23547873_ChIP-Seq_NB4_Human0.77907119
84GATA3_22897851_ChIP-Seq_JUKARTE6-1_Human0.76547611
85* TCF4_18268006_ChIP-ChIP_LS174T_Human0.76405124
86FOXA1_25552417_ChIP-Seq_VCAP_Human0.75888155
87FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human0.73807797
88PPARG_20176806_ChIP-Seq_3T3-L1_Mouse0.73698461
89P63_26484246_Chip-Seq_KERATINOCYTES_Human0.73648815
90FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human0.71743605
91ESR2_21235772_ChIP-Seq_MCF-7_Human0.70933558
92NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse0.69838203
93SCL_19346495_ChIP-Seq_HPC-7_Human0.69379727
94KAP1_22055183_ChIP-Seq_ESCs_Mouse0.67275931
95EGR1_19032775_ChIP-ChIP_M12_Human0.66847115
96TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.66470983
97CEBPB_22108803_ChIP-Seq_LS180_Human0.65048601
98GATA6_25053715_ChIP-Seq_YYC3_Human0.64448386
99SREBP2_21459322_ChIP-Seq_LIVER_Mouse0.62914177
100VDR_24787735_ChIP-Seq_THP-1_Human0.61488000
101LYL1_20887958_ChIP-Seq_HPC-7_Mouse0.58681847
102CDX2_19796622_ChIP-Seq_MESCs_Mouse0.58488946
103AR_20517297_ChIP-Seq_VCAP_Human0.57797121
104BMI1_19503595_ChIP-Seq_MEFsC_Mouse0.56660359
105AUTS2_25519132_ChIP-Seq_293T-REX_Human0.56052193
106GATA2_20887958_ChIP-Seq_HPC-7_Mouse0.54295596
107PPARG_20887899_ChIP-Seq_3T3-L1_Mouse0.53865404
108RARA_24833708_ChIP-Seq_LIVER_Mouse0.53533326
109TRIM28_21343339_ChIP-Seq_HEK293_Human0.53501959
110* GATA1_22383799_ChIP-Seq_G1ME_Mouse0.53424416
111PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse0.53237287
112* TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse0.52327157
113* GATA2_22383799_ChIP-Seq_G1ME_Mouse0.51958186
114RUNX1_20887958_ChIP-Seq_HPC-7_Mouse0.51807978
115CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human0.51049199
116ESR1_22446102_ChIP-Seq_UTERUS_Mouse0.50711345
117PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse0.50710023
118CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse0.50533465
119FOXA1_26743006_Chip-Seq_LNCaP-abl_Human0.49542025
120CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.49255327
121PPARD_23208498_ChIP-Seq_MDA-MB-231_Human0.49223938
122PU_27001747_Chip-Seq_BMDM_Mouse0.49209381
123LMO2_20887958_ChIP-Seq_HPC-7_Mouse0.48969330
124CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse0.48501125
125MYC_19915707_ChIP-ChIP_AK7_Human0.48136565
126SREBP1_19666523_ChIP-Seq_LIVER_Mouse0.47369474
127PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.46216702
128ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human0.46196568

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002139_abnormal_hepatobiliary_system7.67411268
2MP0005360_urolithiasis6.65846106
3MP0005085_abnormal_gallbladder_physiolo5.71205483
4MP0005365_abnormal_bile_salt5.61392730
5MP0008875_abnormal_xenobiotic_pharmacok4.33600050
6MP0003252_abnormal_bile_duct3.63927535
7MP0008004_abnormal_stomach_pH3.56987288
8MP0003806_abnormal_nucleotide_metabolis3.46628362
9MP0010329_abnormal_lipoprotein_level3.37299623
10MP0003191_abnormal_cellular_cholesterol3.35900654
11MP0009840_abnormal_foam_cell3.14047448
12MP0005083_abnormal_biliary_tract2.60231170
13MP0001666_abnormal_nutrient_absorption2.59947960
14MP0000465_gastrointestinal_hemorrhage2.59715745
15MP0003195_calcinosis2.55154296
16MP0004019_abnormal_vitamin_homeostasis2.38661692
17MP0005332_abnormal_amino_acid2.36523491
18* MP0000609_abnormal_liver_physiology2.06882330
19MP0002138_abnormal_hepatobiliary_system2.01651424
20MP0002118_abnormal_lipid_homeostasis1.90290146
21MP0010155_abnormal_intestine_physiology1.83450383
22MP0003656_abnormal_erythrocyte_physiolo1.79747290
23MP0009697_abnormal_copulation1.70396987
24MP0001545_abnormal_hematopoietic_system1.70266759
25MP0005397_hematopoietic_system_phenotyp1.70266759
26MP0005319_abnormal_enzyme/_coenzyme1.63436721
27MP0005167_abnormal_blood-brain_barrier1.60154828
28MP0003868_abnormal_feces_composition1.57025106
29MP0001764_abnormal_homeostasis1.56244138
30MP0001664_abnormal_digestion1.49136395
31MP0002254_reproductive_system_inflammat1.44907342
32MP0009643_abnormal_urine_homeostasis1.38522637
33MP0005584_abnormal_enzyme/coenzyme_acti1.32702238
34MP0001765_abnormal_ion_homeostasis1.28802384
35MP0009764_decreased_sensitivity_to1.28068609
36MP0003866_abnormal_defecation1.27895693
37MP0003186_abnormal_redox_activity1.27465524
38MP0005451_abnormal_body_composition1.22084641
39MP0010368_abnormal_lymphatic_system1.21146017
40MP0005084_abnormal_gallbladder_morpholo1.17413878
41MP0000598_abnormal_liver_morphology1.17016421
42MP0000604_amyloidosis1.16706439
43MP0003436_decreased_susceptibility_to1.13406195
44MP0003705_abnormal_hypodermis_morpholog1.12114850
45MP0008469_abnormal_protein_level1.11721960
46MP0008775_abnormal_heart_ventricle1.09212030
47MP0009763_increased_sensitivity_to1.08652373
48* MP0005636_abnormal_mineral_homeostasis1.08534009
49MP0005058_abnormal_lysosome_morphology1.07553963
50MP0001851_eye_inflammation1.07242708
51MP0002132_abnormal_respiratory_system1.07081789
52MP0003011_delayed_dark_adaptation1.05870727
53MP0005408_hypopigmentation1.05662592
54MP0002166_altered_tumor_susceptibility1.03736178
55MP0005464_abnormal_platelet_physiology1.02995892
56MP0005647_abnormal_sex_gland1.02133472
57MP0002909_abnormal_adrenal_gland1.00916372
58MP0003724_increased_susceptibility_to1.00574357
59MP0005387_immune_system_phenotype0.99501793
60MP0001790_abnormal_immune_system0.99501793
61MP0001663_abnormal_digestive_system0.99213347
62MP0002148_abnormal_hypersensitivity_rea0.97773486
63MP0004147_increased_porphyrin_level0.96916663
64MP0005165_increased_susceptibility_to0.92224283
65MP0004484_altered_response_of0.92042281
66* MP0009642_abnormal_blood_homeostasis0.91003190
67MP0005409_darkened_coat_color0.90567703
68MP0005000_abnormal_immune_tolerance0.89356498
69MP0002396_abnormal_hematopoietic_system0.89096266
70MP0001800_abnormal_humoral_immune0.84680050
71MP0005220_abnormal_exocrine_pancreas0.84125990
72MP0003300_gastrointestinal_ulcer0.83078417
73MP0001756_abnormal_urination0.81339827
74MP0000343_altered_response_to0.81299426
75MP0003828_pulmonary_edema0.78401285
76MP0003172_abnormal_lysosome_physiology0.78196200
77MP0003879_abnormal_hair_cell0.77653748
78MP0010352_gastrointestinal_tract_polyps0.77109898
79MP0009780_abnormal_chondrocyte_physiolo0.76894432
80MP0002723_abnormal_immune_serum0.76285721
81MP0008872_abnormal_physiological_respon0.75962230
82MP0005376_homeostasis/metabolism_phenot0.74883718
83MP0002078_abnormal_glucose_homeostasis0.74375783
84MP0009765_abnormal_xenobiotic_induced0.73283843
85MP0002928_abnormal_bile_duct0.72959383
86MP0001853_heart_inflammation0.72611354
87MP0002998_abnormal_bone_remodeling0.72166193
88* MP0002419_abnormal_innate_immunity0.72115852
89MP0005670_abnormal_white_adipose0.72013465
90MP0003303_peritoneal_inflammation0.70900699
91MP0003690_abnormal_glial_cell0.70841833
92MP0002971_abnormal_brown_adipose0.70353924
93MP0002136_abnormal_kidney_physiology0.70306536
94MP0001661_extended_life_span0.69114376
95MP0004782_abnormal_surfactant_physiolog0.68391961
96MP0004883_abnormal_blood_vessel0.68136525
97MP0004264_abnormal_extraembryonic_tissu0.65555955
98MP0001845_abnormal_inflammatory_respons0.65084551
99MP0006054_spinal_hemorrhage0.64420034
100MP0005334_abnormal_fat_pad0.63783263
101MP0009785_altered_susceptibility_to0.63474863
102MP0004130_abnormal_muscle_cell0.61558183
103MP0002876_abnormal_thyroid_physiology0.61291169
104MP0000639_abnormal_adrenal_gland0.61158919
105MP0003638_abnormal_response/metabolism_0.60563319
106MP0001879_abnormal_lymphatic_vessel0.60200771
107MP0005166_decreased_susceptibility_to0.58315879
108MP0003075_altered_response_to0.58202677
109MP0000249_abnormal_blood_vessel0.57345542
110MP0010234_abnormal_vibrissa_follicle0.56006286
111MP0006082_CNS_inflammation0.55480498
112MP0002837_dystrophic_cardiac_calcinosis0.54750557
113MP0005025_abnormal_response_to0.54057855
114MP0005164_abnormal_response_to0.53267864
115MP0009278_abnormal_bone_marrow0.53171442
116MP0005448_abnormal_energy_balance0.50433274
117MP0005535_abnormal_body_temperature0.50283991
118MP0001533_abnormal_skeleton_physiology0.49852833
119MP0009053_abnormal_anal_canal0.47336790
120MP0006036_abnormal_mitochondrial_physio0.47304379
121MP0003183_abnormal_peptide_metabolism0.47119994
122MP0003453_abnormal_keratinocyte_physiol0.46696355
123MP0002796_impaired_skin_barrier0.42976025
124MP0004947_skin_inflammation0.42531121
125MP0002098_abnormal_vibrissa_morphology0.42437435
126MP0002060_abnormal_skin_morphology0.41877285
127MP0001835_abnormal_antigen_presentation0.41792810
128MP0005266_abnormal_metabolism0.41734364
129MP0008873_increased_physiological_sensi0.41543717
130MP0001243_abnormal_dermal_layer0.41021385
131MP0000230_abnormal_systemic_arterial0.40170192
132MP0002135_abnormal_kidney_morphology0.38165874

Predicted human phenotypes

RankGene SetZ-score
1Deep venous thrombosis (HP:0002625)6.51988032
2Intrahepatic cholestasis (HP:0001406)6.42533879
3Abnormality of aromatic amino acid family metabolism (HP:0004338)6.35155357
4Prolonged partial thromboplastin time (HP:0003645)5.95035969
5Abnormality of monocarboxylic acid metabolism (HP:0010996)5.87466394
6Xanthomatosis (HP:0000991)5.81646023
7Prolonged bleeding time (HP:0003010)5.62651155
8Hypobetalipoproteinemia (HP:0003563)5.51491116
9Complement deficiency (HP:0004431)5.36115832
10Joint hemorrhage (HP:0005261)4.85386553
11Hyperlipoproteinemia (HP:0010980)4.83020103
12Hypoglycemic coma (HP:0001325)4.57216649
13Purpura (HP:0000979)4.56883831
14Abnormality of the common coagulation pathway (HP:0010990)4.55312792
15Petechiae (HP:0000967)4.53479925
16Hypolipoproteinemia (HP:0010981)4.41611369
17Epistaxis (HP:0000421)4.29672554
18Increased mean platelet volume (HP:0011877)4.23692936
19Abnormality of the level of lipoprotein cholesterol (HP:0010979)4.12233186
20Abnormality of the heme biosynthetic pathway (HP:0010472)4.07738954
21Abnormal platelet volume (HP:0011876)4.07543049
22Hypoalphalipoproteinemia (HP:0003233)4.07448762
23Epidermoid cyst (HP:0200040)4.01270935
24Abnormality of complement system (HP:0005339)3.97908607
25Abnormality of glutamine family amino acid metabolism (HP:0010902)3.96958522
26Hyperammonemia (HP:0001987)3.95961372
27Conjugated hyperbilirubinemia (HP:0002908)3.86921389
28Systemic lupus erythematosus (HP:0002725)3.82934423
29Ketosis (HP:0001946)3.82183399
30Fat malabsorption (HP:0002630)3.81150258
31Abnormality of the intrinsic pathway (HP:0010989)3.75387551
32Abnormality of sulfur amino acid metabolism (HP:0004339)3.71145364
33Abnormality of aspartate family amino acid metabolism (HP:0010899)3.62871733
34Abnormality of methionine metabolism (HP:0010901)3.57254977
35Hypercholesterolemia (HP:0003124)3.56353006
36Abnormality of pyrimidine metabolism (HP:0004353)3.45799485
37Hypoglycemic seizures (HP:0002173)3.43192638
38Decreased circulating renin level (HP:0003351)3.38950853
39Glomerulonephritis (HP:0000099)3.38807456
40Hyperglycinemia (HP:0002154)3.38541516
41Hyperbilirubinemia (HP:0002904)3.36186242
42Hyperglycinuria (HP:0003108)3.36054458
43Recurrent gram-negative bacterial infections (HP:0005420)3.30462273
44Myocardial infarction (HP:0001658)3.18818737
45Abnormality of glycine metabolism (HP:0010895)3.17563886
46Abnormality of serine family amino acid metabolism (HP:0010894)3.17563886
47Abnormality of fatty-acid metabolism (HP:0004359)3.17105446
48Spontaneous hematomas (HP:0007420)3.09395037
49Abnormal platelet function (HP:0011869)2.96777633
50Impaired platelet aggregation (HP:0003540)2.96777633
51Ketoacidosis (HP:0001993)2.96314670
52Hepatocellular carcinoma (HP:0001402)2.95202803
53Abnormality of long-chain fatty-acid metabolism (HP:0010964)2.94797218
54Abnormality of nucleobase metabolism (HP:0010932)2.94619765
55Eczematoid dermatitis (HP:0000976)2.92451679
56Acanthocytosis (HP:0001927)2.87926481
57Hypochromic microcytic anemia (HP:0004840)2.76744317
58Cerebral palsy (HP:0100021)2.75572758
59Hyperinsulinemic hypoglycemia (HP:0000825)2.75301472
60Polycythemia (HP:0001901)2.69891752
61Steatorrhea (HP:0002570)2.69528387
62Abnormality of purine metabolism (HP:0004352)2.69029905
63Esophageal varix (HP:0002040)2.66973815
64Skin nodule (HP:0200036)2.64504776
65Spontaneous abortion (HP:0005268)2.63911212
66Ileus (HP:0002595)2.60241136
67Poikilocytosis (HP:0004447)2.52543734
68Symptomatic seizures (HP:0011145)2.51718021
69Metabolic acidosis (HP:0001942)2.48749118
70Pancreatic islet-cell hyperplasia (HP:0004510)2.45719837
71Dicarboxylic aciduria (HP:0003215)2.42789367
72Abnormality of dicarboxylic acid metabolism (HP:0010995)2.42789367
73Abnormal gallbladder morphology (HP:0012437)2.42733635
74Delayed CNS myelination (HP:0002188)2.39824985
75Vascular calcification (HP:0004934)2.37154324
76Cholelithiasis (HP:0001081)2.33797835
77Gingival bleeding (HP:0000225)2.32922635
78Mitral stenosis (HP:0001718)2.32794629
79Abnormality of serum amino acid levels (HP:0003112)2.28874689
80Nephritis (HP:0000123)2.23830854
81Generalized aminoaciduria (HP:0002909)2.21982716
82Menorrhagia (HP:0000132)2.21097756
83Amyloidosis (HP:0011034)2.20187015
84Ventricular fibrillation (HP:0001663)2.17572765
85Hemorrhage of the eye (HP:0011885)2.16654800
86Enlarged kidneys (HP:0000105)2.15556893
87Abnormality of endocrine pancreas physiology (HP:0012093)2.14552305
88Abnormality of the pancreatic islet cells (HP:0006476)2.14552305
89Gout (HP:0001997)2.14179648
90Late onset (HP:0003584)2.13091959
91Chronic diarrhea (HP:0002028)2.12777555
92Malnutrition (HP:0004395)2.12486481
93Thrombophlebitis (HP:0004418)2.10213267
94Hyperglycemia (HP:0003074)2.10086809
95Irritability (HP:0000737)2.10001728
96Spastic diplegia (HP:0001264)2.09569793
97Glycosuria (HP:0003076)2.09470686
98Abnormality of urine glucose concentration (HP:0011016)2.09470686
99Cardiovascular calcification (HP:0011915)2.09400825
100Sensorimotor neuropathy (HP:0007141)2.08996031
101Pancreatitis (HP:0001733)2.08627052
102Reticulocytosis (HP:0001923)2.07466838
103Lethargy (HP:0001254)2.06683446
104Increased serum ferritin (HP:0003281)2.06499213
105Nausea (HP:0002018)2.02912416
106Abnormality of renin-angiotensin system (HP:0000847)2.02253477
107Microcytic anemia (HP:0001935)2.01226727
108Urinary glycosaminoglycan excretion (HP:0003541)2.00787891
109Mucopolysacchariduria (HP:0008155)2.00787891
110Widely patent fontanelles and sutures (HP:0004492)1.99695622
111Hydroxyprolinuria (HP:0003080)1.99681322
112Abnormality of proline metabolism (HP:0010907)1.99681322
113Abnormality of mucopolysaccharide metabolism (HP:0011020)1.99087536
114Abnormality of polysaccharide metabolism (HP:0011012)1.99087536
115Abnormality of glycosaminoglycan metabolism (HP:0004371)1.99087536
116Abnormal gallbladder physiology (HP:0012438)1.98390351
117Cholecystitis (HP:0001082)1.98390351
118Hyperaldosteronism (HP:0000859)1.96986123
119Abnormality of vitamin metabolism (HP:0100508)1.96894181
120Abnormal enzyme/coenzyme activity (HP:0012379)1.95643595
121Gingivitis (HP:0000230)1.94392757
122Abnormality of macrophages (HP:0004311)1.92385177
123Testicular neoplasm (HP:0010788)1.91678151
124* Abnormality of iron homeostasis (HP:0011031)1.91600338
125Abnormality of the gallbladder (HP:0005264)1.91427524
126Dysostosis multiplex (HP:0000943)1.90846229
127* Abnormality of transition element cation homeostasis (HP:0011030)1.90626440
128Alkalosis (HP:0001948)1.89415055
129Potter facies (HP:0002009)1.88253173
130Facial shape deformation (HP:0011334)1.88253173
131Paralysis (HP:0003470)1.87360361
132Rickets (HP:0002748)1.87200861
133Proximal tubulopathy (HP:0000114)1.86412334
134Pulmonary embolism (HP:0002204)1.86161777
135Myositis (HP:0100614)1.85607172
136Elevated alkaline phosphatase (HP:0003155)1.84484032
137Vacuolated lymphocytes (HP:0001922)1.84273277
138Vomiting (HP:0002013)1.83591137
139Growth hormone excess (HP:0000845)1.82127903
140Congenital sensorineural hearing impairment (HP:0008527)1.81680183
141Gastrointestinal infarctions (HP:0005244)1.80359888
142Bruising susceptibility (HP:0000978)1.79461096
143Opisthotonus (HP:0002179)1.78457479
144Pigmentary retinal degeneration (HP:0001146)1.77802287
145* Joint swelling (HP:0001386)1.76662828
146Arterial thrombosis (HP:0004420)1.73874929
147Gonadal dysgenesis (HP:0000133)1.72713573
148Orchitis (HP:0100796)1.72253224
149Inflammation of the large intestine (HP:0002037)1.70813847
150Recurrent abscess formation (HP:0002722)1.70501212
151Acne (HP:0001061)1.69840430
152Obstructive lung disease (HP:0006536)1.69801752
153Chronic obstructive pulmonary disease (HP:0006510)1.69801752
154Abnormality of the vasculature of the conjunctiva (HP:0008054)1.67875358
155Conjunctival telangiectasia (HP:0000524)1.66629465

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BCKDK4.38014168
2INSRR4.04959316
3ERN13.55308202
4FRK3.46614912
5FGFR43.02932727
6TIE12.95677734
7RIPK42.80187481
8TGFBR22.67161275
9TAOK32.63714417
10KDR2.59374668
11SIK12.54077483
12MST1R2.44571725
13MST42.40354217
14PIK3CG2.26564626
15TYK22.22956617
16PTK62.20479912
17GRK11.93539861
18MAPK151.90058281
19PKN21.79556243
20EIF2AK11.68410956
21MAP2K31.58228658
22TRIB31.57351966
23FLT31.55820112
24BMX1.53963886
25MAPK111.53008496
26IRAK31.48414897
27FER1.47965515
28SYK1.46372484
29MAP3K31.44941437
30CSK1.39191302
31CAMK1D1.37637072
32NEK91.37170809
33TBK11.35919490
34FES1.35675236
35MAP3K101.33388242
36MAP3K141.30264899
37IRAK41.29984282
38ERBB41.27071065
39JAK21.21831187
40PRKAA21.21651144
41PINK11.19658752
42MATK1.18326031
43MAP3K61.14691098
44TNK21.14233055
45MET1.11762678
46NUAK11.11242133
47BMPR21.09623738
48BLK1.08377506
49MAP3K51.07259226
50JAK11.06962612
51MAP3K21.06916561
52EPHB11.03789736
53RET1.02093037
54LATS10.99996533
55MAP2K20.99336125
56TAOK10.96894689
57ITK0.94718100
58TEC0.92817761
59MAPKAPK30.90052901
60CSF1R0.89918643
61GRK60.88124826
62PTK20.87449326
63SCYL20.85867796
64PRPF4B0.83628132
65PRKG20.83619014
66MAP2K60.83560172
67TXK0.82132950
68HIPK20.78630646
69ABL20.75110759
70CDK60.75054045
71SGK30.74910137
72MAP3K120.70674987
73IGF1R0.68755735
74CAMK1G0.67778656
75EPHA20.67658339
76DYRK1B0.67074791
77PDK10.66011572
78PIM10.65877927
79MAPK40.65465634
80EPHA30.64845830
81GSK3A0.64712013
82OBSCN0.63640352
83MAP2K40.62359725
84PIK3CA0.62052278
85MAP2K10.61618252
86TRPM70.61524005
87SGK20.60615543
88MAPK120.60597304
89IKBKE0.58591255
90PRKCQ0.58511419
91LCK0.58209341
92LMTK20.57914236
93PRKAA10.57890755
94MAP4K10.57303760
95AKT30.56889506
96ERBB20.56207229
97PRKCZ0.53904782
98MAPK70.53338092
99ACVR1B0.52721026
100STK100.52376632
101WNK30.51674885
102PRKACG0.51664763
103MYLK0.51266173
104BTK0.51161903
105IKBKB0.50622430
106CDC42BPA0.50435725
107MAPK30.50244203
108FGFR30.49976825
109MAP3K70.48847582
110ZAP700.47645300
111PTK2B0.47077836
112GRK50.46943893
113EGFR0.46763440
114PRKD10.45015440
115OXSR10.44216536
116RIPK10.44082013
117LYN0.43947424
118PBK0.43403218
119FGFR20.43397017
120DAPK20.40731044
121MAP3K110.39363807
122NLK0.37337215
123KIT0.36874321
124TAOK20.35973220
125MAP3K10.35934698
126PDPK10.33865047
127LRRK20.32747352
128GRK70.30598044
129HCK0.30361460
130FGR0.30285754
131PDGFRA0.28583440
132IRAK10.28108486
133JAK30.25794228
134STK30.25574833

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary bile acid biosynthesis_Homo sapiens_hsa001204.23292024
2Nitrogen metabolism_Homo sapiens_hsa009103.57006341
3Ascorbate and aldarate metabolism_Homo sapiens_hsa000533.32963976
4Complement and coagulation cascades_Homo sapiens_hsa046103.05793339
5Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004002.97516610
6Arginine biosynthesis_Homo sapiens_hsa002202.93208798
7Tryptophan metabolism_Homo sapiens_hsa003802.63118162
8Fatty acid degradation_Homo sapiens_hsa000712.51699965
9Staphylococcus aureus infection_Homo sapiens_hsa051502.48173876
10Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010402.39870445
11Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006302.35573004
12Pentose and glucuronate interconversions_Homo sapiens_hsa000402.28958369
13Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.25221319
14Glycine, serine and threonine metabolism_Homo sapiens_hsa002602.23047489
15Drug metabolism - cytochrome P450_Homo sapiens_hsa009822.07602099
16Histidine metabolism_Homo sapiens_hsa003402.07198307
17Peroxisome_Homo sapiens_hsa041462.05438466
18PPAR signaling pathway_Homo sapiens_hsa033201.99193889
19Caffeine metabolism_Homo sapiens_hsa002321.95164752
20Butanoate metabolism_Homo sapiens_hsa006501.90836580
21Steroid hormone biosynthesis_Homo sapiens_hsa001401.83999691
22Chemical carcinogenesis_Homo sapiens_hsa052041.82438733
23Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.78327574
24beta-Alanine metabolism_Homo sapiens_hsa004101.74514883
25Propanoate metabolism_Homo sapiens_hsa006401.71765006
26Fatty acid metabolism_Homo sapiens_hsa012121.68962157
27Retinol metabolism_Homo sapiens_hsa008301.66837747
28Bile secretion_Homo sapiens_hsa049761.66028872
29Drug metabolism - other enzymes_Homo sapiens_hsa009831.65751972
30ABC transporters_Homo sapiens_hsa020101.65122890
31Platelet activation_Homo sapiens_hsa046111.64439028
32Selenocompound metabolism_Homo sapiens_hsa004501.64246752
33Maturity onset diabetes of the young_Homo sapiens_hsa049501.53868160
34Sulfur metabolism_Homo sapiens_hsa009201.53800229
35Phenylalanine metabolism_Homo sapiens_hsa003601.50920378
36Fat digestion and absorption_Homo sapiens_hsa049751.49840134
37Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.48881959
38Starch and sucrose metabolism_Homo sapiens_hsa005001.46743942
39Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.39296084
40Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.35419492
41Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.27638065
42Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.25456493
43Tyrosine metabolism_Homo sapiens_hsa003501.25216965
44Folate biosynthesis_Homo sapiens_hsa007901.22015746
45Vitamin digestion and absorption_Homo sapiens_hsa049771.20230901
46Fatty acid elongation_Homo sapiens_hsa000621.18556432
472-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.12171204
48Pyruvate metabolism_Homo sapiens_hsa006201.08570153
49Asthma_Homo sapiens_hsa053100.97449111
50Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.95026121
51Steroid biosynthesis_Homo sapiens_hsa001000.93775110
52Carbon metabolism_Homo sapiens_hsa012000.92421270
53Arginine and proline metabolism_Homo sapiens_hsa003300.91863564
54Cysteine and methionine metabolism_Homo sapiens_hsa002700.90080647
55Biosynthesis of amino acids_Homo sapiens_hsa012300.87434439
56Hematopoietic cell lineage_Homo sapiens_hsa046400.86644547
57Lysine degradation_Homo sapiens_hsa003100.84504696
58Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.83042618
59Protein digestion and absorption_Homo sapiens_hsa049740.82152817
60Pancreatic secretion_Homo sapiens_hsa049720.81837528
61Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.81211866
62Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.77924456
63Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.77468843
64Cyanoamino acid metabolism_Homo sapiens_hsa004600.73471679
65Glycerolipid metabolism_Homo sapiens_hsa005610.69300736
66Glutathione metabolism_Homo sapiens_hsa004800.65949592
67Allograft rejection_Homo sapiens_hsa053300.61799627
68Sulfur relay system_Homo sapiens_hsa041220.61768227
69Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.61762794
70Vascular smooth muscle contraction_Homo sapiens_hsa042700.59471815
71Pentose phosphate pathway_Homo sapiens_hsa000300.59185059
72Autoimmune thyroid disease_Homo sapiens_hsa053200.58775608
73Renin secretion_Homo sapiens_hsa049240.57342404
74Vitamin B6 metabolism_Homo sapiens_hsa007500.53886126
75SNARE interactions in vesicular transport_Homo sapiens_hsa041300.49563313
76Glycosaminoglycan degradation_Homo sapiens_hsa005310.49417152
77Intestinal immune network for IgA production_Homo sapiens_hsa046720.49032356
78Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.48177918
79Sphingolipid metabolism_Homo sapiens_hsa006000.48168166
80Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.47347276
81Galactose metabolism_Homo sapiens_hsa000520.47042766
82One carbon pool by folate_Homo sapiens_hsa006700.45808094
83Graft-versus-host disease_Homo sapiens_hsa053320.45799166
84Type I diabetes mellitus_Homo sapiens_hsa049400.41797580
85Insulin resistance_Homo sapiens_hsa049310.41402536
86alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.40003104
87Metabolic pathways_Homo sapiens_hsa011000.38888057
88Jak-STAT signaling pathway_Homo sapiens_hsa046300.37968711
89Prion diseases_Homo sapiens_hsa050200.35753214
90Chemokine signaling pathway_Homo sapiens_hsa040620.33417446
91Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.33352961
92Osteoclast differentiation_Homo sapiens_hsa043800.32246995
93Linoleic acid metabolism_Homo sapiens_hsa005910.30295458
94Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.29653485
95Tuberculosis_Homo sapiens_hsa051520.28986135
96Toxoplasmosis_Homo sapiens_hsa051450.26352238
97Fructose and mannose metabolism_Homo sapiens_hsa000510.24581714
98B cell receptor signaling pathway_Homo sapiens_hsa046620.24453092
99Glycerophospholipid metabolism_Homo sapiens_hsa005640.24001586
100Adipocytokine signaling pathway_Homo sapiens_hsa049200.22537763
101ECM-receptor interaction_Homo sapiens_hsa045120.22374534
102Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.22288954
103Serotonergic synapse_Homo sapiens_hsa047260.21956811
104Lysosome_Homo sapiens_hsa041420.19769678
105Other glycan degradation_Homo sapiens_hsa005110.18868472
106Fatty acid biosynthesis_Homo sapiens_hsa000610.17382315
107Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.13879966
108* Mineral absorption_Homo sapiens_hsa049780.10543029
109Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.10507868
110Pertussis_Homo sapiens_hsa051330.08371250
111Ovarian steroidogenesis_Homo sapiens_hsa049130.07851705
112Arachidonic acid metabolism_Homo sapiens_hsa005900.06553933
113Renin-angiotensin system_Homo sapiens_hsa046140.03843971
114Hepatitis C_Homo sapiens_hsa051600.03706461
115Glucagon signaling pathway_Homo sapiens_hsa049220.03063745
116Carbohydrate digestion and absorption_Homo sapiens_hsa049730.02117947
117AMPK signaling pathway_Homo sapiens_hsa041520.01587087
118Leukocyte transendothelial migration_Homo sapiens_hsa04670-0.1107245
119Amoebiasis_Homo sapiens_hsa05146-0.1073630
120Insulin signaling pathway_Homo sapiens_hsa04910-0.1018726
121Systemic lupus erythematosus_Homo sapiens_hsa05322-0.0866290
122Toll-like receptor signaling pathway_Homo sapiens_hsa04620-0.0814463
123Ether lipid metabolism_Homo sapiens_hsa00565-0.0789799
124Malaria_Homo sapiens_hsa05144-0.0715728
125Legionellosis_Homo sapiens_hsa05134-0.0681674
126Leishmaniasis_Homo sapiens_hsa05140-0.0307329
127African trypanosomiasis_Homo sapiens_hsa05143-0.0191310

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