SLC41A1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1sarcomere organization (GO:0045214)6.82027415
2muscle filament sliding (GO:0030049)6.40823050
3actin-myosin filament sliding (GO:0033275)6.40823050
4myofibril assembly (GO:0030239)5.79960988
5actin-mediated cell contraction (GO:0070252)5.37325697
6cardiac muscle hypertrophy (GO:0003300)5.27073908
7sarcoplasmic reticulum calcium ion transport (GO:0070296)5.17064630
8sodium ion export (GO:0071436)5.14027691
9regulation of relaxation of muscle (GO:1901077)5.00825518
10striated muscle hypertrophy (GO:0014897)5.00700160
11regulation of the force of heart contraction (GO:0002026)4.83268226
12actomyosin structure organization (GO:0031032)4.73045591
13cellular potassium ion homeostasis (GO:0030007)4.69570176
14bundle of His cell to Purkinje myocyte communication (GO:0086069)4.67720053
15regulation of cell communication by electrical coupling (GO:0010649)4.53507112
16cardiac muscle tissue morphogenesis (GO:0055008)4.48311561
17muscle hypertrophy (GO:0014896)4.34104466
18cell communication by electrical coupling (GO:0010644)4.33960867
19response to stimulus involved in regulation of muscle adaptation (GO:0014874)4.31942683
20ventricular cardiac muscle tissue morphogenesis (GO:0055010)4.27629265
21cardiac muscle cell development (GO:0055013)4.21721424
22regulation of ventricular cardiac muscle cell membrane repolarization (GO:0060307)4.20850002
23actin filament-based movement (GO:0030048)4.19870449
24cell communication by electrical coupling involved in cardiac conduction (GO:0086064)4.18355902
25adult heart development (GO:0007512)4.15395020
26muscle tissue morphogenesis (GO:0060415)4.15224714
27NADH metabolic process (GO:0006734)4.09502560
28potassium ion import (GO:0010107)4.05262439
29muscle hypertrophy in response to stress (GO:0003299)4.03195915
30cardiac muscle adaptation (GO:0014887)4.03195915
31cardiac muscle hypertrophy in response to stress (GO:0014898)4.03195915
32regulation of cardioblast differentiation (GO:0051890)4.00768126
33cardiac cell development (GO:0055006)4.00384285
34regulation of striated muscle contraction (GO:0006942)3.80410340
35response to inactivity (GO:0014854)3.65782656
36cellular response to epinephrine stimulus (GO:0071872)3.51577788
37carnitine shuttle (GO:0006853)3.50852431
38atrioventricular valve morphogenesis (GO:0003181)3.46654914
39locomotory exploration behavior (GO:0035641)3.44968245
40skeletal muscle contraction (GO:0003009)3.44573454
41cellular sodium ion homeostasis (GO:0006883)3.41309702
42neurological system process involved in regulation of systemic arterial blood pressure (GO:0001976)3.39741644
43regulation of heart rate (GO:0002027)3.36727799
44cell-substrate adherens junction assembly (GO:0007045)3.33401650
45focal adhesion assembly (GO:0048041)3.33401650
46muscle contraction (GO:0006936)3.31632082
47desmosome organization (GO:0002934)3.27859507
48detection of calcium ion (GO:0005513)3.25823783
49heart trabecula formation (GO:0060347)3.24898012
50regulation of cardiac muscle contraction (GO:0055117)3.23771999
51response to epinephrine (GO:0071871)3.22348575
52potassium ion homeostasis (GO:0055075)3.21089651
53membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.20701124
54adherens junction assembly (GO:0034333)3.18903408
55tricarboxylic acid cycle (GO:0006099)3.18412819
56amino acid import (GO:0043090)3.17257699
57striated muscle adaptation (GO:0014888)3.15180747
58cardiac muscle cell action potential involved in contraction (GO:0086002)3.13845317
59regulation of membrane repolarization (GO:0060306)3.12698576
60positive regulation of potassium ion transmembrane transporter activity (GO:1901018)3.11886817
61cell communication involved in cardiac conduction (GO:0086065)3.08463880
62regulation of heart contraction (GO:0008016)3.07004788
63alanine transport (GO:0032328)3.06343121
64negative regulation of cytosolic calcium ion concentration (GO:0051481)3.02302784
65muscle system process (GO:0003012)3.02181384
66regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion (GO3.01956584
67peripheral nervous system axon ensheathment (GO:0032292)2.99350646
68myelination in peripheral nervous system (GO:0022011)2.99350646
69heart contraction (GO:0060047)2.99071860
70heart process (GO:0003015)2.99071860
71negative regulation of cardiac muscle cell apoptotic process (GO:0010667)2.98890375
72ventricular cardiac muscle cell development (GO:0055015)2.97888990
73L-amino acid import (GO:0043092)2.96287703
74negative regulation of potassium ion transmembrane transport (GO:1901380)2.95012714
75atrial septum morphogenesis (GO:0060413)2.94046370
76regulation of synapse structural plasticity (GO:0051823)2.92628610
77cell-substrate junction assembly (GO:0007044)2.90247391
78layer formation in cerebral cortex (GO:0021819)2.88374955
79regulation of cardiac muscle cell contraction (GO:0086004)2.86330133
80regulation of calcineurin-NFAT signaling cascade (GO:0070884)2.85598091
81regulation of p38MAPK cascade (GO:1900744)2.84463866
82regulation of actin filament-based movement (GO:1903115)2.84438098
83positive regulation of glycogen biosynthetic process (GO:0045725)2.83695883
84muscle cell cellular homeostasis (GO:0046716)2.83359162
85regulation of ATPase activity (GO:0043462)2.83064318
86regulation of ATP catabolic process (GO:1903289)2.83064318
87regulation of cardiac muscle contraction by calcium ion signaling (GO:0010882)2.82474277
88glial cell proliferation (GO:0014009)2.80960736
89regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum (GO:0010880)2.80636370
90ovulation cycle (GO:0042698)2.78204774
91plasma membrane repair (GO:0001778)2.78193172
92negative regulation of heart growth (GO:0061117)2.77544853
93negative regulation of cardiac muscle tissue growth (GO:0055022)2.77544853
94cardiac chamber formation (GO:0003207)2.77187896
95negative regulation of potassium ion transmembrane transporter activity (GO:1901017)2.76854923
96cardiac conduction (GO:0061337)2.74975683
97membrane repolarization (GO:0086009)2.74833432
98endothelial cell chemotaxis (GO:0035767)2.74736720
99fatty acid transmembrane transport (GO:1902001)2.73300232
100positive regulation of potassium ion transmembrane transport (GO:1901381)2.72920983
101cell migration involved in heart development (GO:0060973)2.71830714
102L-serine transport (GO:0015825)2.71692928
103calcium-mediated signaling using intracellular calcium source (GO:0035584)2.71020809
104C4-dicarboxylate transport (GO:0015740)2.70852301
105epithelial cell-cell adhesion (GO:0090136)2.68449918
106striated muscle cell development (GO:0055002)2.66070800
107cardiac muscle contraction (GO:0060048)2.66009983
108exocrine pancreas development (GO:0031017)2.65794598
109cardiac ventricle formation (GO:0003211)2.64162977
110serine transport (GO:0032329)2.63864828
111regulation of muscle system process (GO:0090257)2.61941843
112regulation of muscle contraction (GO:0006937)2.61699408
113positive regulation of heart contraction (GO:0045823)2.61595710
114positive regulation of ryanodine-sensitive calcium-release channel activity (GO:0060316)2.57644071
115synaptic vesicle maturation (GO:0016188)2.55718303
116regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)2.53632900
117cytoskeletal anchoring at plasma membrane (GO:0007016)2.53232441
118positive regulation of transcription from RNA polymerase II promoter in response to stress (GO:003602.51905014
119regulation of short-term neuronal synaptic plasticity (GO:0048172)2.51258522
120regulation of ARF protein signal transduction (GO:0032012)2.47725761
121regulation of skeletal muscle contraction (GO:0014819)2.45975155
122proline transport (GO:0015824)2.45496061
123negative regulation of amyloid precursor protein catabolic process (GO:1902992)2.41742093
124regulation of ryanodine-sensitive calcium-release channel activity (GO:0060314)2.41636459
125creatine metabolic process (GO:0006600)2.39881242
126positive regulation of potassium ion transport (GO:0043268)2.39658335
127negative regulation of astrocyte differentiation (GO:0048712)2.39515234
128positive regulation of sodium ion transport (GO:0010765)2.39514619
129gamma-aminobutyric acid transport (GO:0015812)2.38087227
130positive regulation of sodium ion transmembrane transport (GO:1902307)2.36882999
131positive regulation of glycogen metabolic process (GO:0070875)2.33827792
132relaxation of cardiac muscle (GO:0055119)2.33536980
133negative regulation of fatty acid transport (GO:2000192)2.33502126
134dermatan sulfate biosynthetic process (GO:0030208)2.31701572
135ventricular cardiac muscle cell action potential (GO:0086005)2.30719810
136establishment of nucleus localization (GO:0040023)2.30583374
137positive regulation of macrophage cytokine production (GO:0060907)2.29408966
138striated muscle contraction (GO:0006941)2.29151376
139exploration behavior (GO:0035640)2.28857261
140regulation of potassium ion transmembrane transport (GO:1901379)2.28715934
141regulation of interleukin-12 biosynthetic process (GO:0045075)2.28203503
142positive regulation of calcium ion transmembrane transporter activity (GO:1901021)2.28040396
143activation of protein kinase A activity (GO:0034199)2.27906522
144response to auditory stimulus (GO:0010996)2.27596510
145growth hormone receptor signaling pathway (GO:0060396)2.27186069
146peptidyl-proline hydroxylation (GO:0019511)2.26122070
147cardiac myofibril assembly (GO:0055003)2.25424158
148positive regulation of p38MAPK cascade (GO:1900745)2.25197964
149neurotransmitter-gated ion channel clustering (GO:0072578)2.24263249
150positive regulation of excitatory postsynaptic membrane potential (GO:2000463)2.23792276
151cell migration involved in sprouting angiogenesis (GO:0002042)2.23451052
152protein retention in ER lumen (GO:0006621)2.21397027
153insulin-like growth factor receptor signaling pathway (GO:0048009)2.21051554
154chondroitin sulfate catabolic process (GO:0030207)2.21030780
155regulation of sodium ion transport (GO:0002028)2.20471820
156positive regulation of synaptic transmission, glutamatergic (GO:0051968)2.19979615
157regulation of tight junction assembly (GO:2000810)2.18482082
158cardiac muscle cell action potential (GO:0086001)2.18130699
159dermatan sulfate metabolic process (GO:0030205)2.17386023
160auditory behavior (GO:0031223)2.17264814
161regulation of calcium ion transmembrane transporter activity (GO:1901019)2.16357346
162regulation of calcium ion transmembrane transport (GO:1903169)2.16357346
163protein hydroxylation (GO:0018126)2.16341756
164vocalization behavior (GO:0071625)2.16175087
165neuromuscular junction development (GO:0007528)2.15808546
166regulation of long-term neuronal synaptic plasticity (GO:0048169)2.15641207
167glycine transport (GO:0015816)2.13468019
168negative regulation of catenin import into nucleus (GO:0035414)2.13334926
169regulation of neuronal synaptic plasticity (GO:0048168)2.12891411
170cellular response to vascular endothelial growth factor stimulus (GO:0035924)2.12539573

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1AR_21572438_ChIP-Seq_LNCaP_Human2.50256860
2NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.38049853
3EZH2_22144423_ChIP-Seq_EOC_Human2.30382035
4TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse2.30118547
5PPARG_19300518_ChIP-PET_3T3-L1_Mouse2.25110494
6SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.23865601
7ESR2_21235772_ChIP-Seq_MCF-7_Human2.18733723
8STAT6_20620947_ChIP-Seq_CD4_POS_T_Human2.11662744
9DROSHA_22980978_ChIP-Seq_HELA_Human2.07220726
10MEF2A_21415370_ChIP-Seq_HL-1_Mouse2.01358907
11EZH2_18974828_ChIP-Seq_MESCs_Mouse1.95959853
12RNF2_18974828_ChIP-Seq_MESCs_Mouse1.95959853
13MTF2_20144788_ChIP-Seq_MESCs_Mouse1.90837033
14RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.90288872
15TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.90000026
16SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.87033808
17* KDM2B_26808549_Chip-Seq_SUP-B15_Human1.86389739
18SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.84917015
19* NKX2-5_21415370_ChIP-Seq_HL-1_Mouse1.82962685
20WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.79710354
21GATA4_21415370_ChIP-Seq_HL-1_Mouse1.78882510
22KDM2B_26808549_Chip-Seq_K562_Human1.77364346
23EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.76582022
24TRIM28_21343339_ChIP-Seq_HEK293_Human1.75526471
25ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.75408738
26ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.72294413
27* RARB_27405468_Chip-Seq_BRAIN_Mouse1.72167816
28TP63_17297297_ChIP-ChIP_HaCaT_Human1.71750535
29JARID2_20064375_ChIP-Seq_MESCs_Mouse1.71089794
30JARID2_20075857_ChIP-Seq_MESCs_Mouse1.70537054
31SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.69964869
32* KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.69706886
33RNF2_27304074_Chip-Seq_ESCs_Mouse1.68461637
34TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.67975251
35ELK3_25401928_ChIP-Seq_HUVEC_Human1.66881316
36STAT6_21828071_ChIP-Seq_BEAS2B_Human1.65685758
37CLOCK_20551151_ChIP-Seq_293T_Human1.65517063
38SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.65093034
39EP300_21415370_ChIP-Seq_HL-1_Mouse1.62282385
40SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.60328135
41WT1_19549856_ChIP-ChIP_CCG9911_Human1.58051142
42EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.57839012
43ZNF217_24962896_ChIP-Seq_MCF-7_Human1.57188409
44ERG_21242973_ChIP-ChIP_JURKAT_Human1.56718439
45THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.55749100
46ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.54973598
47SUZ12_27294783_Chip-Seq_ESCs_Mouse1.46847633
48* TBX20_22328084_ChIP-Seq_HEART_Mouse1.46123591
49* TBX20_22080862_ChIP-Seq_HEART_Mouse1.46123591
50RARG_19884340_ChIP-ChIP_MEFs_Mouse1.45886870
51IKZF1_21737484_ChIP-ChIP_HCT116_Human1.45755071
52* KDM2B_26808549_Chip-Seq_DND41_Human1.44366065
53NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.44037309
54* KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.43878553
55SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.43689526
56RXR_22108803_ChIP-Seq_LS180_Human1.43257523
57* ZFP281_18757296_ChIP-ChIP_E14_Mouse1.43186133
58ESR1_21235772_ChIP-Seq_MCF-7_Human1.41088612
59SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.39582725
60EZH2_27294783_Chip-Seq_ESCs_Mouse1.39001427
61SMAD_19615063_ChIP-ChIP_OVARY_Human1.36967464
62WT1_25993318_ChIP-Seq_PODOCYTE_Human1.36192139
63ESR1_20079471_ChIP-ChIP_T-47D_Human1.35448486
64EED_16625203_ChIP-ChIP_MESCs_Mouse1.34436705
65TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.33402126
66* ZFP281_27345836_Chip-Seq_ESCs_Mouse1.33238941
67FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.32507497
68* CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.31910913
69KDM2B_26808549_Chip-Seq_JURKAT_Human1.31716729
70ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.30672611
71TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.30560014
72ZNF263_19887448_ChIP-Seq_K562_Human1.30556602
73EZH2_27304074_Chip-Seq_ESCs_Mouse1.28890834
74MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.28697901
75UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.28478668
76* TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.27535725
77ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.27505570
78EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.27045842
79RUNX_20019798_ChIP-Seq_JUKART_Human1.26943225
80EGR1_19374776_ChIP-ChIP_THP-1_Human1.26517200
81AR_21909140_ChIP-Seq_LNCAP_Human1.26418036
82FOXO3_23340844_ChIP-Seq_DLD1_Human1.24874034
83* NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.22361138
84SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.21570888
85KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.21204579
86CDX2_19796622_ChIP-Seq_MESCs_Mouse1.20434460
87TP53_16413492_ChIP-PET_HCT116_Human1.20255176
88PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.18868390
89RING1B_27294783_Chip-Seq_ESCs_Mouse1.18053727
90DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.17583538
91DNAJC2_21179169_ChIP-ChIP_NT2_Human1.16872483
92AHR_22903824_ChIP-Seq_MCF-7_Human1.16593954
93LXR_22292898_ChIP-Seq_THP-1_Human1.15397677
94TP53_23651856_ChIP-Seq_MEFs_Mouse1.15176225
95TET1_21490601_ChIP-Seq_MESCs_Mouse1.14765074
96RUNX1_27514584_Chip-Seq_MCF-7_Human1.14693430
97SALL4_18804426_ChIP-ChIP_XEN_Mouse1.14387725
98ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.12961400
99SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.10994160
100SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.10994160
101TRIM28_17542650_ChIP-ChIP_NTERA2_Human1.10975173
102VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.10085898
103* KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.09904767
104ATF3_27146783_Chip-Seq_COLON_Human1.09357040
105HIF1A_21447827_ChIP-Seq_MCF-7_Human1.09254792
106SOX9_24532713_ChIP-Seq_HFSC_Mouse1.09206656
107ISL1_27105846_Chip-Seq_CPCs_Mouse1.09142941
108PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.08446098
109FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.08387765
110STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.05507924
111GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.05484809
112* AR_19668381_ChIP-Seq_PC3_Human1.04893364
113ARNT_22903824_ChIP-Seq_MCF-7_Human1.04858013
114GATA1_22025678_ChIP-Seq_K562_Human1.04668104
115TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.04241568
116UBF1/2_26484160_Chip-Seq_HMECs_Human1.04036013
117SMC4_20622854_ChIP-Seq_HELA_Human1.03628499
118SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.03085439
119SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.02956612
120* RACK7_27058665_Chip-Seq_MCF-7_Human1.01702375
121CTNNB1_20460455_ChIP-Seq_HCT116_Human1.01686364
122BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.01591598
123SMAD3_21741376_ChIP-Seq_HESCs_Human1.00900289
124ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.00580542
125SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.00113242
126NR3C1_23031785_ChIP-Seq_PC12_Mouse0.99673833
127ZFP322A_24550733_ChIP-Seq_MESCs_Mouse0.99658766
128RING1B_27294783_Chip-Seq_NPCs_Mouse0.98803442
129RUNX2_24764292_ChIP-Seq_MC3T3_Mouse0.98377992
130ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.97850242
131PPAR_26484153_Chip-Seq_NCI-H1993_Human0.97585686
132* CREB1_26743006_Chip-Seq_LNCaP_Human0.97447069
133* CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat0.95983431
134P300_27058665_Chip-Seq_ZR-75-30cells_Human0.95446930
135TCF7_22412390_ChIP-Seq_EML_Mouse0.95237540
136STAT3_19079543_ChIP-ChIP_MESCs_Mouse0.94457250
137GATA3_20176728_ChIP-ChIP_TSCs_Mouse0.93889069
138GATA2_21666600_ChIP-Seq_HMVEC_Human0.93395580
139SREBP1_19666523_ChIP-Seq_LIVER_Mouse0.93162718
140NFIB_24661679_ChIP-Seq_LUNG_Mouse0.93149575
141CREB1_26743006_Chip-Seq_LNCaP-abl_Human0.92766045
142REST_21632747_ChIP-Seq_MESCs_Mouse0.90697303
143KLF5_25053715_ChIP-Seq_YYC3_Human0.89618152
144CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human0.89544014

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0000751_myopathy3.37040467
2MP0004859_abnormal_synaptic_plasticity3.14995622
3MP0003646_muscle_fatigue2.70163783
4MP0009780_abnormal_chondrocyte_physiolo2.60600095
5MP0002254_reproductive_system_inflammat2.51672244
6MP0003705_abnormal_hypodermis_morpholog2.37074551
7MP0003300_gastrointestinal_ulcer2.34615597
8MP0004233_abnormal_muscle_weight2.29660966
9MP0000750_abnormal_muscle_regeneration2.25615896
10MP0004215_abnormal_myocardial_fiber2.16391759
11MP0004858_abnormal_nervous_system2.09482617
12MP0009384_cardiac_valve_regurgitation2.03808596
13MP0010368_abnormal_lymphatic_system2.01562592
14MP0004885_abnormal_endolymph1.97046730
15MP0004084_abnormal_cardiac_muscle1.96641904
16MP0008961_abnormal_basal_metabolism1.95825928
17MP0004130_abnormal_muscle_cell1.93384078
18MP0004087_abnormal_muscle_fiber1.90494087
19MP0005623_abnormal_meninges_morphology1.83561503
20MP0003045_fibrosis1.83303710
21MP0004510_myositis1.79585302
22MP0003690_abnormal_glial_cell1.79412977
23MP0003635_abnormal_synaptic_transmissio1.74528587
24MP0008569_lethality_at_weaning1.74340845
25MP0000749_muscle_degeneration1.73063683
26MP0002089_abnormal_postnatal_growth/wei1.66235041
27MP0003329_amyloid_beta_deposits1.65570489
28MP0003279_aneurysm1.62138545
29MP0005083_abnormal_biliary_tract1.60483965
30MP0004036_abnormal_muscle_relaxation1.57392430
31MP0005451_abnormal_body_composition1.56632187
32MP0002837_dystrophic_cardiac_calcinosis1.56614755
33MP0002332_abnormal_exercise_endurance1.52608551
34MP0005423_abnormal_somatic_nervous1.52438798
35MP0004145_abnormal_muscle_electrophysio1.52034337
36MP0002106_abnormal_muscle_physiology1.51916721
37MP0002127_abnormal_cardiovascular_syste1.50023891
38MP0008438_abnormal_cutaneous_collagen1.47635910
39MP0003075_altered_response_to1.43657328
40MP0003950_abnormal_plasma_membrane1.43436878
41MP0000733_abnormal_muscle_development1.41609744
42MP0000747_muscle_weakness1.40612137
43MP0005620_abnormal_muscle_contractility1.37696725
44MP0010234_abnormal_vibrissa_follicle1.36337873
45MP0002972_abnormal_cardiac_muscle1.35579877
46MP0005369_muscle_phenotype1.35095729
47MP0002909_abnormal_adrenal_gland1.34902905
48MP0004484_altered_response_of1.32980560
49MP0004185_abnormal_adipocyte_glucose1.32798772
50MP0004270_analgesia1.31131280
51MP0003828_pulmonary_edema1.29721025
52MP0005330_cardiomyopathy1.27900659
53MP0003137_abnormal_impulse_conducting1.27900214
54MP0005409_darkened_coat_color1.27837011
55MP0005275_abnormal_skin_tensile1.26766204
56MP0009745_abnormal_behavioral_response1.25709504
57MP0002063_abnormal_learning/memory/cond1.24450988
58MP0000759_abnormal_skeletal_muscle1.24360804
59MP0001502_abnormal_circadian_rhythm1.24274442
60MP0001958_emphysema1.24017907
61MP0002108_abnormal_muscle_morphology1.21615130
62MP0002822_catalepsy1.21459287
63MP0005165_increased_susceptibility_to1.21137539
64MP0001661_extended_life_span1.21003402
65MP0010630_abnormal_cardiac_muscle1.21001460
66MP0005503_abnormal_tendon_morphology1.20894172
67MP0002269_muscular_atrophy1.19474782
68MP0002877_abnormal_melanocyte_morpholog1.19026301
69MP0001881_abnormal_mammary_gland1.18586324
70MP0003221_abnormal_cardiomyocyte_apopto1.18573258
71MP0005666_abnormal_adipose_tissue1.15943080
72MP0005167_abnormal_blood-brain_barrier1.15875091
73MP0003633_abnormal_nervous_system1.14123882
74MP0001299_abnormal_eye_distance/1.12605147
75MP0005375_adipose_tissue_phenotype1.09976224
76MP0003303_peritoneal_inflammation1.09280220
77MP0003941_abnormal_skin_development1.09234473
78MP0005646_abnormal_pituitary_gland1.09224301
79MP0001486_abnormal_startle_reflex1.06659965
80MP0009046_muscle_twitch1.06474722
81MP0002090_abnormal_vision1.05557764
82MP0002064_seizures1.05386609
83MP0000266_abnormal_heart_morphology1.04700541
84MP0000003_abnormal_adipose_tissue1.02655262
85MP0006138_congestive_heart_failure1.01815443
86MP0001544_abnormal_cardiovascular_syste1.01280033
87MP0005385_cardiovascular_system_phenoty1.01280033
88MP0008775_abnormal_heart_ventricle0.99977927
89MP0003634_abnormal_glial_cell0.98761528
90MP0003566_abnormal_cell_adhesion0.98514187
91MP0001440_abnormal_grooming_behavior0.97804182
92MP0000579_abnormal_nail_morphology0.97604342
93MP0001873_stomach_inflammation0.94004552
94MP0001501_abnormal_sleep_pattern0.93300910
95MP0000767_abnormal_smooth_muscle0.92489758
96MP0003091_abnormal_cell_migration0.91698593
97MP0002128_abnormal_blood_circulation0.89358659
98MP0004272_abnormal_basement_membrane0.89308990
99MP0005377_hearing/vestibular/ear_phenot0.89043202
100MP0003878_abnormal_ear_physiology0.89043202
101MP0005076_abnormal_cell_differentiation0.88758168
102MP0000762_abnormal_tongue_morphology0.88543869
103MP0000013_abnormal_adipose_tissue0.88113294
104MP0010352_gastrointestinal_tract_polyps0.87118560
105MP0004085_abnormal_heartbeat0.85725075
106MP0002572_abnormal_emotion/affect_behav0.84907000
107MP0003763_abnormal_thymus_physiology0.83844103
108MP0002272_abnormal_nervous_system0.81557322
109MP0000428_abnormal_craniofacial_morphol0.80857485
110MP0001879_abnormal_lymphatic_vessel0.79649578
111MP0010030_abnormal_orbit_morphology0.78842123
112MP0005508_abnormal_skeleton_morphology0.76854634
113MP0002896_abnormal_bone_mineralization0.75958392
114MP0001348_abnormal_lacrimal_gland0.75928207
115MP0005670_abnormal_white_adipose0.74421056
116MP0008004_abnormal_stomach_pH0.72135426
117MP0004924_abnormal_behavior0.71669250
118MP0005386_behavior/neurological_phenoty0.71669250
119MP0000604_amyloidosis0.71103895
120MP0003631_nervous_system_phenotype0.71051036
121MP0001849_ear_inflammation0.71036956
122MP0002295_abnormal_pulmonary_circulatio0.66152557
123MP0005023_abnormal_wound_healing0.62540220
124MP0002925_abnormal_cardiovascular_devel0.62433139
125MP0002060_abnormal_skin_morphology0.60096741
126MP0003984_embryonic_growth_retardation0.59889509
127MP0009672_abnormal_birth_weight0.59691239
128MP0002971_abnormal_brown_adipose0.58220387
129MP0001730_embryonic_growth_arrest0.56984592
130MP0002088_abnormal_embryonic_growth/wei0.55662311
131MP0000534_abnormal_ureter_morphology0.53845878
132MP0003453_abnormal_keratinocyte_physiol0.52696523
133MP0002249_abnormal_larynx_morphology0.52416014
134MP0009250_abnormal_appendicular_skeleto0.52082062
135MP0001614_abnormal_blood_vessel0.51721545
136MP0005257_abnormal_intraocular_pressure0.48999741
137MP0002796_impaired_skin_barrier0.48110824
138MP0001915_intracranial_hemorrhage0.46015942
139MP0005380_embryogenesis_phenotype0.45713098
140MP0001672_abnormal_embryogenesis/_devel0.45713098
141MP0000343_altered_response_to0.45143509

Predicted human phenotypes

RankGene SetZ-score
1Distal lower limb muscle weakness (HP:0009053)4.56334088
2Nemaline bodies (HP:0003798)4.52511371
3Lipoatrophy (HP:0100578)4.15442236
4Centrally nucleated skeletal muscle fibers (HP:0003687)4.08063450
5Aplasia involving bones of the upper limbs (HP:0009823)3.92979869
6Aplasia of the phalanges of the hand (HP:0009802)3.92979869
7Aplasia involving bones of the extremities (HP:0009825)3.92979869
8Exercise-induced myalgia (HP:0003738)3.85810239
9Dilated cardiomyopathy (HP:0001644)3.66669219
10Neck muscle weakness (HP:0000467)3.45627439
11Megalencephaly (HP:0001355)3.37100478
12Exercise-induced muscle cramps (HP:0003710)3.33627617
13Difficulty running (HP:0009046)3.15512872
14EMG: neuropathic changes (HP:0003445)3.13455011
15Broad metatarsal (HP:0001783)3.05741448
16Sudden death (HP:0001699)2.98328270
17Muscle fiber splitting (HP:0003555)2.90630558
18Type 1 muscle fiber predominance (HP:0003803)2.83260698
19Abnormality of the calf musculature (HP:0001430)2.80811215
20Abnormality of the foot musculature (HP:0001436)2.80405042
21Round ear (HP:0100830)2.78052392
22Hyporeflexia of lower limbs (HP:0002600)2.77827312
23Aplasia/Hypoplasia of the pubic bone (HP:0009104)2.72073248
24Increased connective tissue (HP:0009025)2.69869374
25Spinal rigidity (HP:0003306)2.66556094
26Rhabdomyolysis (HP:0003201)2.63315063
27Foot dorsiflexor weakness (HP:0009027)2.61947781
28Myopathic facies (HP:0002058)2.60188073
29Ragged-red muscle fibers (HP:0003200)2.59177169
30Palpitations (HP:0001962)2.58027444
31Calf muscle hypertrophy (HP:0008981)2.54695013
32Prolonged QT interval (HP:0001657)2.53126267
33Hypoplastic ischia (HP:0003175)2.51743731
34Hemiplegia (HP:0002301)2.51190473
35Atrial fibrillation (HP:0005110)2.51159575
36Abnormality of binocular vision (HP:0011514)2.45717007
37Diplopia (HP:0000651)2.45717007
38Rimmed vacuoles (HP:0003805)2.45297619
39Areflexia of lower limbs (HP:0002522)2.44679963
40Shallow orbits (HP:0000586)2.41451195
41Muscle hypertrophy of the lower extremities (HP:0008968)2.40675300
42Primary atrial arrhythmia (HP:0001692)2.39241811
43Short hallux (HP:0010109)2.38229601
44Increased variability in muscle fiber diameter (HP:0003557)2.37548704
45Mildly elevated creatine phosphokinase (HP:0008180)2.33882028
46Protrusio acetabuli (HP:0003179)2.25315996
47Right ventricular cardiomyopathy (HP:0011663)2.24729831
48Difficulty climbing stairs (HP:0003551)2.24076033
49Aplasia/Hypoplasia of the hallux (HP:0008362)2.23499385
50Generalized muscle weakness (HP:0003324)2.23162212
51Premature rupture of membranes (HP:0001788)2.21863093
52Bundle branch block (HP:0011710)2.21224031
53Ventricular arrhythmia (HP:0004308)2.20532362
54Supraventricular tachycardia (HP:0004755)2.19706013
55Muscle fiber inclusion bodies (HP:0100299)2.19510258
56Supraventricular arrhythmia (HP:0005115)2.18553209
57Atrioventricular block (HP:0001678)2.18278909
58Abnormality of skeletal muscle fiber size (HP:0012084)2.15863406
59Abnormality of the tricuspid valve (HP:0001702)2.15813393
60Cerebral aneurysm (HP:0004944)2.15781555
61EMG: myopathic abnormalities (HP:0003458)2.14811288
62Abnormality of the ischium (HP:0003174)2.14714069
63Myoglobinuria (HP:0002913)2.13224974
64Abnormal atrioventricular conduction (HP:0005150)2.12971570
65Dysmetric saccades (HP:0000641)2.11199549
66Heart block (HP:0012722)2.10805723
67Ankle contracture (HP:0006466)2.09358904
68Ventricular tachycardia (HP:0004756)2.07880740
69Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)2.07848484
70Abnormality of the middle phalanges of the toes (HP:0010183)2.07476699
71Lower limb amyotrophy (HP:0007210)2.05384618
72Myotonia (HP:0002486)2.04811431
73Hemiparesis (HP:0001269)2.04391127
74Ventricular fibrillation (HP:0001663)2.02482297
75Progressive muscle weakness (HP:0003323)2.00129455
76Neonatal short-limb short stature (HP:0008921)1.99363703
77Distal lower limb amyotrophy (HP:0008944)1.97406605
78Adactyly (HP:0009776)1.97229898
79Bulbar palsy (HP:0001283)1.95237380
80Overgrowth (HP:0001548)1.95001271
81Obstructive sleep apnea (HP:0002870)1.93703590
82Action tremor (HP:0002345)1.93097308
83Focal seizures (HP:0007359)1.90819319
84Syncope (HP:0001279)1.89986358
85Aneurysm (HP:0002617)1.89844005
86Aortic aneurysm (HP:0004942)1.88969637
87Abnormality of the left ventricular outflow tract (HP:0011103)1.88952679
88Subaortic stenosis (HP:0001682)1.88952679
89Gowers sign (HP:0003391)1.88644009
90Bronchomalacia (HP:0002780)1.87631660
91Sudden cardiac death (HP:0001645)1.87504158
92Macroorchidism (HP:0000053)1.86627039
93Ulnar deviation of the wrist (HP:0003049)1.86238387
94Focal motor seizures (HP:0011153)1.84672229
95Cone-shaped epiphyses of the phalanges of the hand (HP:0010230)1.84294526
96Left ventricular hypertrophy (HP:0001712)1.82649734
97Scapular winging (HP:0003691)1.81952468
98Palmoplantar keratoderma (HP:0000982)1.80202524
99Arterial tortuosity (HP:0005116)1.79925532
100Mitral valve prolapse (HP:0001634)1.79270613
101Calcaneovalgus deformity (HP:0001848)1.78581925
102Vascular tortuosity (HP:0004948)1.78478009
103Generalized amyotrophy (HP:0003700)1.77972735
104Hypoplastic left heart (HP:0004383)1.77481805
105Muscular dystrophy (HP:0003560)1.76624744
106Epiphyseal dysplasia (HP:0002656)1.75077320
107Neoplasm of the heart (HP:0100544)1.74470207
108Asymmetric septal hypertrophy (HP:0001670)1.74184248
109Abnormality of the shoulder girdle musculature (HP:0001435)1.74162543
110Enlarged penis (HP:0000040)1.73745817
111Steppage gait (HP:0003376)1.73424710
112Proximal amyotrophy (HP:0007126)1.71464285
113Limb-girdle muscle weakness (HP:0003325)1.71451089
114Tarsal synostosis (HP:0008368)1.71176037
115Distal upper limb amyotrophy (HP:0007149)1.70861070
116Upper limb amyotrophy (HP:0009129)1.70861070
117Abnormality of the salivary glands (HP:0010286)1.69365812
118Fatigue (HP:0012378)1.69293327
119Bradycardia (HP:0001662)1.69053503
120Supranuclear gaze palsy (HP:0000605)1.68911018
121Maternal diabetes (HP:0009800)1.68267477
122Visual hallucinations (HP:0002367)1.67911628
123Limb-girdle muscle atrophy (HP:0003797)1.67856558
124Premature skin wrinkling (HP:0100678)1.66526468
125Hypoplastic heart (HP:0001961)1.65220980
126Osteolytic defects of the hand bones (HP:0009699)1.63996959
127Osteolytic defects of the phalanges of the hand (HP:0009771)1.63996959
128Abnormality of the epiphyses of the phalanges of the hand (HP:0005920)1.63595982
129Abnormal EKG (HP:0003115)1.62493981
130Long nose (HP:0003189)1.62476348
131Fragile skin (HP:0001030)1.61671679
132Mitral regurgitation (HP:0001653)1.61275057
133Distal arthrogryposis (HP:0005684)1.60810460
134Humeroradial synostosis (HP:0003041)1.60755545
135Synostosis involving the elbow (HP:0003938)1.60755545
136Cerebral inclusion bodies (HP:0100314)1.59578818
137Frequent falls (HP:0002359)1.59416062
138Limited hip movement (HP:0008800)1.59231204
139Achilles tendon contracture (HP:0001771)1.58923841
140Dysdiadochokinesis (HP:0002075)1.58809440
141Decreased number of large peripheral myelinated nerve fibers (HP:0003387)1.58612825
142Trigonocephaly (HP:0000243)1.58001074
143Muscle stiffness (HP:0003552)1.57910261
144Diaphragmatic weakness (HP:0009113)1.56019571
145Ulnar bowing (HP:0003031)1.55314236

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TRIB34.87023001
2MYLK3.62001000
3LMTK22.81210527
4RIPK12.70945756
5PHKG22.59331653
6PHKG12.59331653
7SIK12.52465995
8EPHA42.50677145
9TTN2.48352031
10DMPK2.24371748
11PKN22.21208191
12PRPF4B1.97743097
13NTRK21.74738986
14MAP3K71.74527605
15PRKD31.72778135
16TAOK11.70182728
17EPHB11.67025858
18EEF2K1.52641261
19OBSCN1.47035041
20NEK91.41756541
21PDGFRA1.39582646
22EPHA31.37351236
23ERN11.35792224
24NTRK31.34565268
25FGFR31.30778511
26TYRO31.29649752
27STK381.29393756
28DDR21.25321713
29MUSK1.21315880
30LIMK11.20830884
31BMX1.19297843
32PTK21.17880176
33LATS11.17531815
34SMG11.16691478
35PTK61.15756984
36TRPM71.14020977
37PIK3CA1.13589982
38RET1.11600468
39PDGFRB1.11119501
40PAK61.09818302
41MAP3K91.08648271
42CAMK2D1.08309615
43MAPK121.08134739
44FGFR41.03670774
45CAMK1G1.02057618
46MET1.00830651
47EPHA20.99954251
48PRKCH0.96869251
49CAMKK10.95683348
50SGK30.95585726
51MAP3K40.95437520
52TESK10.94833281
53MARK10.94542311
54KSR20.93715392
55MAP3K60.88597158
56JAK10.87855730
57ARAF0.87721333
58MOS0.85462014
59NTRK10.83518894
60DAPK20.83232252
61BCKDK0.82109826
62CAMK1D0.80837073
63SCYL20.80725803
64ROCK20.80219480
65TNIK0.79202533
66FGFR10.79027659
67FER0.78356074
68CAMK2G0.77571866
69ROCK10.74964741
70PAK30.74349957
71CDC42BPA0.73717270
72PDK20.73355463
73MAP3K100.71924758
74LRRK20.71582643
75CDK120.69738109
76SGK20.67616297
77PRKAA10.67086787
78ILK0.66968394
79PRKD10.66395725
80STK40.66261923
81MAPK70.66128233
82PDK30.65605443
83PDK40.65605443
84AKT20.65375220
85CAMK2B0.64899485
86MINK10.63203880
87FGFR20.62867721
88MTOR0.61778386
89ALK0.60902471
90SGK10.60683738
91MAP3K30.60317438
92MAP2K30.60066455
93PINK10.60006877
94RPS6KL10.59831319
95RPS6KC10.59831319
96STK110.59458050
97ERBB40.59417450
98CDK50.58447347
99ICK0.58410523
100CAMK10.56219232
101WNK10.56145843
102CHUK0.55932748
103MAPK100.55814252
104PAK20.55044230
105KSR10.54431735
106PDK10.53452260
107PAK40.53189987
108MAP3K10.52596058
109JAK30.52242764
110MARK20.51280585
111LATS20.50820623
112TGFBR20.50427523
113RPS6KA20.49768496
114SGK4940.48578252
115SGK2230.48578252
116DYRK1A0.47803147
117NEK60.47168349
118RAF10.47116497
119RPS6KA10.46766667
120PRKAA20.46460172
121PDPK10.46437689
122NEK10.45449665
123AKT30.45379228
124MST1R0.45240288
125MAP2K10.45147411
126MAP2K20.44696990
127MAP3K20.44483840
128PRKD20.44410545
129CAMK40.42866577
130NLK0.42672940
131CAMK2A0.42388009
132MAP2K40.42128991
133MAPK40.41050603
134MAPK110.40975180
135MAP3K130.40010621
136BRAF0.39423950
137RPS6KA30.39186107
138MAPKAPK30.39089713
139ZAP700.39035072
140PIK3CG0.38954224
141RPS6KA60.38161708
142TAOK20.38095005
143BRD40.37699183
144RPS6KB20.36660751
145UHMK10.36288203

Predicted pathways (KEGG)

RankGene SetZ-score
1Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004002.90965760
2Nitrogen metabolism_Homo sapiens_hsa009102.56838716
3Fatty acid biosynthesis_Homo sapiens_hsa000612.47367917
4Pancreatic secretion_Homo sapiens_hsa049722.35668094
5Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049642.15402205
6Dilated cardiomyopathy_Homo sapiens_hsa054141.82961247
7Gastric acid secretion_Homo sapiens_hsa049711.70587413
8Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.66186707
9Salivary secretion_Homo sapiens_hsa049701.57531425
10Protein digestion and absorption_Homo sapiens_hsa049741.53717956
11Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.51495124
12Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054101.50696121
13Carbon metabolism_Homo sapiens_hsa012001.49948018
14Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.49764941
15Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.47510036
16Circadian entrainment_Homo sapiens_hsa047131.35506784
17Insulin secretion_Homo sapiens_hsa049111.34007744
18Dorso-ventral axis formation_Homo sapiens_hsa043201.31047479
19Aldosterone synthesis and secretion_Homo sapiens_hsa049251.30615912
20Long-term potentiation_Homo sapiens_hsa047201.25730328
21Thyroid hormone signaling pathway_Homo sapiens_hsa049191.25461789
22Glutamatergic synapse_Homo sapiens_hsa047241.24510504
23Renin secretion_Homo sapiens_hsa049241.23561890
24GABAergic synapse_Homo sapiens_hsa047271.23287836
25Adipocytokine signaling pathway_Homo sapiens_hsa049201.22355170
26Prion diseases_Homo sapiens_hsa050201.20228147
27Regulation of lipolysis in adipocytes_Homo sapiens_hsa049231.17999042
28cAMP signaling pathway_Homo sapiens_hsa040241.15455223
29Calcium signaling pathway_Homo sapiens_hsa040201.14782466
30Biosynthesis of amino acids_Homo sapiens_hsa012301.13597869
31Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.13429982
32Pyruvate metabolism_Homo sapiens_hsa006201.11265618
33Oxytocin signaling pathway_Homo sapiens_hsa049211.10653174
34Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.10140636
35Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.09898741
36Olfactory transduction_Homo sapiens_hsa047401.09606469
37Circadian rhythm_Homo sapiens_hsa047101.09259166
38Nicotine addiction_Homo sapiens_hsa050331.09220270
39AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.08803091
40cGMP-PKG signaling pathway_Homo sapiens_hsa040221.07562972
41Viral myocarditis_Homo sapiens_hsa054161.07054599
42Pentose phosphate pathway_Homo sapiens_hsa000301.06386857
43Phenylalanine metabolism_Homo sapiens_hsa003601.05994149
44Morphine addiction_Homo sapiens_hsa050321.04049668
45Cocaine addiction_Homo sapiens_hsa050301.03345724
46GnRH signaling pathway_Homo sapiens_hsa049121.02298487
47Arginine and proline metabolism_Homo sapiens_hsa003301.01677069
48Cholinergic synapse_Homo sapiens_hsa047251.01237465
49Insulin resistance_Homo sapiens_hsa049310.98220611
50Cardiac muscle contraction_Homo sapiens_hsa042600.97517327
51Focal adhesion_Homo sapiens_hsa045100.96907560
52Estrogen signaling pathway_Homo sapiens_hsa049150.95372417
53Amphetamine addiction_Homo sapiens_hsa050310.93463756
54Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.93208550
55Carbohydrate digestion and absorption_Homo sapiens_hsa049730.93207273
56Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.90707082
57ECM-receptor interaction_Homo sapiens_hsa045120.89953914
58Proteoglycans in cancer_Homo sapiens_hsa052050.88920152
59VEGF signaling pathway_Homo sapiens_hsa043700.88260906
60Phospholipase D signaling pathway_Homo sapiens_hsa040720.87803659
61Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.87537436
62mTOR signaling pathway_Homo sapiens_hsa041500.85670834
63Type II diabetes mellitus_Homo sapiens_hsa049300.85398568
64Longevity regulating pathway - mammal_Homo sapiens_hsa042110.84686603
65Neurotrophin signaling pathway_Homo sapiens_hsa047220.84245654
66Arginine biosynthesis_Homo sapiens_hsa002200.83340337
67Endometrial cancer_Homo sapiens_hsa052130.83128222
68Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.82819768
69Lysine degradation_Homo sapiens_hsa003100.82210505
70Glioma_Homo sapiens_hsa052140.80972568
71MAPK signaling pathway_Homo sapiens_hsa040100.80656623
72Thyroid cancer_Homo sapiens_hsa052160.80052442
73Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.79368567
74Gap junction_Homo sapiens_hsa045400.78774986
75Toxoplasmosis_Homo sapiens_hsa051450.78258542
76Regulation of actin cytoskeleton_Homo sapiens_hsa048100.78061183
77Vascular smooth muscle contraction_Homo sapiens_hsa042700.77969497
78Insulin signaling pathway_Homo sapiens_hsa049100.77325346
79Adherens junction_Homo sapiens_hsa045200.76994177
80Melanogenesis_Homo sapiens_hsa049160.74771432
81Glucagon signaling pathway_Homo sapiens_hsa049220.74638827
82Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.74282172
83Dopaminergic synapse_Homo sapiens_hsa047280.74181772
84Fatty acid metabolism_Homo sapiens_hsa012120.74053761
85Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.73047960
86Central carbon metabolism in cancer_Homo sapiens_hsa052300.72972722
87Prolactin signaling pathway_Homo sapiens_hsa049170.72336923
88Non-small cell lung cancer_Homo sapiens_hsa052230.71930887
89Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.71329672
90Phosphatidylinositol signaling system_Homo sapiens_hsa040700.71042165
91ErbB signaling pathway_Homo sapiens_hsa040120.70935962
92Glycerolipid metabolism_Homo sapiens_hsa005610.70469067
93Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.69359416
94Rap1 signaling pathway_Homo sapiens_hsa040150.68852870
952-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.68076029
96Thyroid hormone synthesis_Homo sapiens_hsa049180.67960342
97Chronic myeloid leukemia_Homo sapiens_hsa052200.67783165
98Notch signaling pathway_Homo sapiens_hsa043300.66114351
99T cell receptor signaling pathway_Homo sapiens_hsa046600.65566774
100Bladder cancer_Homo sapiens_hsa052190.65476297
101Pancreatic cancer_Homo sapiens_hsa052120.64930674
102Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.64915511
103Renal cell carcinoma_Homo sapiens_hsa052110.64118857
104Bile secretion_Homo sapiens_hsa049760.62760763
105Osteoclast differentiation_Homo sapiens_hsa043800.62506731
106Amoebiasis_Homo sapiens_hsa051460.62231256
107Small cell lung cancer_Homo sapiens_hsa052220.62137061
108Prostate cancer_Homo sapiens_hsa052150.61820152
109Long-term depression_Homo sapiens_hsa047300.61651242
110Tight junction_Homo sapiens_hsa045300.61143572
111Ovarian steroidogenesis_Homo sapiens_hsa049130.60543443
112Hippo signaling pathway_Homo sapiens_hsa043900.60519801
113Choline metabolism in cancer_Homo sapiens_hsa052310.60141466
114Fructose and mannose metabolism_Homo sapiens_hsa000510.59644793
115Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.59335599
116Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.59140047
117HIF-1 signaling pathway_Homo sapiens_hsa040660.58270541
118Colorectal cancer_Homo sapiens_hsa052100.58048294
119MicroRNAs in cancer_Homo sapiens_hsa052060.57647897
120Basal cell carcinoma_Homo sapiens_hsa052170.57060123
121AMPK signaling pathway_Homo sapiens_hsa041520.55598742
122Propanoate metabolism_Homo sapiens_hsa006400.54790867
123Acute myeloid leukemia_Homo sapiens_hsa052210.54766558
124Galactose metabolism_Homo sapiens_hsa000520.54655694
125Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.52701909
126PPAR signaling pathway_Homo sapiens_hsa033200.52307261
127Fat digestion and absorption_Homo sapiens_hsa049750.52273218
128Inositol phosphate metabolism_Homo sapiens_hsa005620.51482651
129FoxO signaling pathway_Homo sapiens_hsa040680.48482066
130Fatty acid elongation_Homo sapiens_hsa000620.48379785
131Melanoma_Homo sapiens_hsa052180.46753681
132Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.44905361

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