SLC41A2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)5.44661450
2L-phenylalanine catabolic process (GO:0006559)5.44661450
3complement activation, alternative pathway (GO:0006957)5.37369937
4regulation of protein activation cascade (GO:2000257)5.25787514
5aromatic amino acid family catabolic process (GO:0009074)5.15282851
6erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)5.14257141
7L-phenylalanine metabolic process (GO:0006558)5.14257141
8indole-containing compound catabolic process (GO:0042436)4.96475775
9indolalkylamine catabolic process (GO:0046218)4.96475775
10tryptophan catabolic process (GO:0006569)4.96475775
11regulation of complement activation (GO:0030449)4.95066015
12protein carboxylation (GO:0018214)4.90916837
13peptidyl-glutamic acid carboxylation (GO:0017187)4.90916837
14triglyceride-rich lipoprotein particle remodeling (GO:0034370)4.88609445
15kynurenine metabolic process (GO:0070189)4.79193796
16urea cycle (GO:0000050)4.70502777
17urea metabolic process (GO:0019627)4.70502777
18tryptophan metabolic process (GO:0006568)4.64646498
19negative regulation of fibrinolysis (GO:0051918)4.52645802
20bile acid biosynthetic process (GO:0006699)4.51827676
21regulation of fibrinolysis (GO:0051917)4.36681909
22cysteine metabolic process (GO:0006534)4.31702364
23high-density lipoprotein particle remodeling (GO:0034375)4.27409832
24nitrogen cycle metabolic process (GO:0071941)4.26779415
25sulfur amino acid catabolic process (GO:0000098)4.06819349
26reverse cholesterol transport (GO:0043691)4.04958005
27glyoxylate metabolic process (GO:0046487)4.04244210
28alpha-linolenic acid metabolic process (GO:0036109)4.03957060
29negative regulation of protein activation cascade (GO:2000258)4.00222275
30homocysteine metabolic process (GO:0050667)3.99498556
31positive regulation of heterotypic cell-cell adhesion (GO:0034116)3.99489392
32epoxygenase P450 pathway (GO:0019373)3.88160214
33fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)3.84072710
34bile acid metabolic process (GO:0008206)3.81467783
35fibrinolysis (GO:0042730)3.80553286
36coenzyme catabolic process (GO:0009109)3.79820768
37protein-lipid complex remodeling (GO:0034368)3.74537806
38macromolecular complex remodeling (GO:0034367)3.74537806
39plasma lipoprotein particle remodeling (GO:0034369)3.74537806
40regulation of triglyceride catabolic process (GO:0010896)3.70015706
41exogenous drug catabolic process (GO:0042738)3.69305260
42aromatic amino acid family metabolic process (GO:0009072)3.67306773
43water-soluble vitamin biosynthetic process (GO:0042364)3.65669503
44acute-phase response (GO:0006953)3.63176041
45phospholipid efflux (GO:0033700)3.62845885
46plasma lipoprotein particle clearance (GO:0034381)3.61714472
47cholesterol efflux (GO:0033344)3.60440788
48complement activation, classical pathway (GO:0006958)3.59673213
49regulation of cholesterol esterification (GO:0010872)3.56957922
50xenobiotic catabolic process (GO:0042178)3.56882746
51bile acid and bile salt transport (GO:0015721)3.55638036
52indolalkylamine metabolic process (GO:0006586)3.55053024
53tyrosine metabolic process (GO:0006570)3.53608690
54complement activation (GO:0006956)3.52248330
55acylglycerol homeostasis (GO:0055090)3.50766297
56triglyceride homeostasis (GO:0070328)3.50766297
57omega-hydroxylase P450 pathway (GO:0097267)3.48309960
58lysine metabolic process (GO:0006553)3.47739257
59lysine catabolic process (GO:0006554)3.47739257
60serine family amino acid catabolic process (GO:0009071)3.46534648
61dicarboxylic acid biosynthetic process (GO:0043650)3.45537868
62cellular glucuronidation (GO:0052695)3.44251980
63opsonization (GO:0008228)3.39983026
64cellular ketone body metabolic process (GO:0046950)3.38212289
65phospholipid homeostasis (GO:0055091)3.35225588
66cellular modified amino acid catabolic process (GO:0042219)3.35061086
67protein activation cascade (GO:0072376)3.34330409
68cytolysis (GO:0019835)3.31712667
69heme transport (GO:0015886)3.30010013
70cellular biogenic amine catabolic process (GO:0042402)3.28954571
71amine catabolic process (GO:0009310)3.28954571
72glutamate metabolic process (GO:0006536)3.25434659
73negative regulation of cholesterol transport (GO:0032375)3.24846951
74negative regulation of sterol transport (GO:0032372)3.24846951
75cofactor catabolic process (GO:0051187)3.23669917
76vitamin biosynthetic process (GO:0009110)3.23370067
77alpha-amino acid catabolic process (GO:1901606)3.22497807
78uronic acid metabolic process (GO:0006063)3.20394752
79glucuronate metabolic process (GO:0019585)3.20394752
80regulation of cholesterol homeostasis (GO:2000188)3.16132741
81benzene-containing compound metabolic process (GO:0042537)3.14773553
82eosinophil chemotaxis (GO:0048245)3.14698687
83lipoprotein metabolic process (GO:0042157)3.14025417
84arginine metabolic process (GO:0006525)3.13812048
85amino-acid betaine metabolic process (GO:0006577)3.13154251
86regulation of plasminogen activation (GO:0010755)3.10074477
87positive regulation of heat generation (GO:0031652)3.07760092
88positive regulation of lipid catabolic process (GO:0050996)3.07537791
89positive regulation of fatty acid biosynthetic process (GO:0045723)3.04536018
90aldehyde catabolic process (GO:0046185)3.02303838
91plasma lipoprotein particle assembly (GO:0034377)3.01230639
92cellular amino acid catabolic process (GO:0009063)2.98947262
93regulation of humoral immune response (GO:0002920)2.98819736
94phenylpropanoid metabolic process (GO:0009698)2.98361869
95transcytosis (GO:0045056)2.93931511
96drug catabolic process (GO:0042737)2.93625882
97positive regulation of calcium ion import (GO:0090280)2.93146510
98positive regulation of triglyceride lipase activity (GO:0061365)2.92673508
99positive regulation of lipoprotein lipase activity (GO:0051006)2.92673508
100S-adenosylmethionine metabolic process (GO:0046500)2.91954767
101low-density lipoprotein particle remodeling (GO:0034374)2.89757307
102regulation of bile acid biosynthetic process (GO:0070857)2.88284885
103plasma lipoprotein particle organization (GO:0071827)2.87930753
104ketone body metabolic process (GO:1902224)2.86367293
105regulation of fever generation (GO:0031620)2.85142050
106negative regulation of hemostasis (GO:1900047)2.84700267
107negative regulation of blood coagulation (GO:0030195)2.84700267
108regulation of type B pancreatic cell apoptotic process (GO:2000674)2.84560940
109negative regulation of complement activation (GO:0045916)2.84272645
110oligosaccharide catabolic process (GO:0009313)2.83945197
111protein-lipid complex assembly (GO:0065005)2.83710780
112drug transmembrane transport (GO:0006855)2.83569202
113positive regulation of blood coagulation (GO:0030194)2.82399906
114positive regulation of hemostasis (GO:1900048)2.82399906
115regulation of heat generation (GO:0031650)2.81151569
116fat-soluble vitamin biosynthetic process (GO:0042362)2.81070630
117protein-lipid complex subunit organization (GO:0071825)2.78615989
118very-low-density lipoprotein particle assembly (GO:0034379)2.78182563
119eosinophil migration (GO:0072677)2.74831331
120regulation of mononuclear cell migration (GO:0071675)2.73991358
121negative regulation of inflammatory response to antigenic stimulus (GO:0002862)2.73941619
122regulation of cytokine secretion involved in immune response (GO:0002739)2.63257462
123regulation of hexokinase activity (GO:1903299)2.63194180
124regulation of glucokinase activity (GO:0033131)2.63194180
125positive regulation of granulocyte macrophage colony-stimulating factor production (GO:0032725)2.56902559
126retinal metabolic process (GO:0042574)2.56635354
127drug metabolic process (GO:0017144)2.52027603
128positive regulation of glycolytic process (GO:0045821)2.51643751
129retinol metabolic process (GO:0042572)2.48801158
130iron coordination entity transport (GO:1901678)2.48270933
131positive regulation of interleukin-8 biosynthetic process (GO:0045416)2.47669082
132endocrine pancreas development (GO:0031018)2.47301016
133oxidative demethylation (GO:0070989)2.45786791
134nitric oxide biosynthetic process (GO:0006809)2.45274719
135zinc ion transport (GO:0006829)2.44828633
136vitamin D metabolic process (GO:0042359)2.44479583
137regulation of chronic inflammatory response (GO:0002676)2.43875664
138positive regulation of prostaglandin secretion (GO:0032308)2.43801408
139membrane lipid catabolic process (GO:0046466)2.42989153
140regulation of acrosome reaction (GO:0060046)2.42825877
141flavonoid metabolic process (GO:0009812)2.42635283
142macroautophagy (GO:0016236)2.41781678
143positive regulation of insulin secretion involved in cellular response to glucose stimulus (GO:003572.40793141
144platelet dense granule organization (GO:0060155)2.40532027
145positive regulation of glycoprotein biosynthetic process (GO:0010560)2.40067672
146regulation of prostaglandin secretion (GO:0032306)2.37192219
147vasodilation (GO:0042311)2.35256652
148insulin secretion (GO:0030073)2.33082099
149sphingolipid catabolic process (GO:0030149)2.32006721
150regulation of vitamin D biosynthetic process (GO:0060556)2.30450341
151regulation of vitamin metabolic process (GO:0030656)2.29477125
152negative regulation of coagulation (GO:0050819)2.29399595
153urate metabolic process (GO:0046415)2.29352851
154positive regulation of nitric oxide biosynthetic process (GO:0045429)2.28111303
155peptide hormone processing (GO:0016486)2.27682386
156regulation of granulocyte macrophage colony-stimulating factor production (GO:0032645)2.27562138
157magnesium ion transport (GO:0015693)2.26903736
158sphingosine metabolic process (GO:0006670)2.26860890
159regulation of ER to Golgi vesicle-mediated transport (GO:0060628)2.26464996
160cobalamin metabolic process (GO:0009235)2.24781214

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1ESR1_17901129_ChIP-ChIP_LIVER_Mouse7.10035470
2RXR_22158963_ChIP-Seq_LIVER_Mouse5.08011009
3PPARA_22158963_ChIP-Seq_LIVER_Mouse4.23764485
4FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse4.20997171
5* LXR_22158963_ChIP-Seq_LIVER_Mouse4.20755177
6EGR1_23403033_ChIP-Seq_LIVER_Mouse4.03409784
7FOXO1_23066095_ChIP-Seq_LIVER_Mouse3.23941209
8* NR1I2_20693526_ChIP-Seq_LIVER_Mouse3.01128021
9CEBPA_23403033_ChIP-Seq_LIVER_Mouse2.58174447
10PPARG_19300518_ChIP-PET_3T3-L1_Mouse2.20048064
11CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.97809782
12* Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.94251681
13TRIM28_21343339_ChIP-Seq_HEK293_Human1.93298874
14IRF8_22096565_ChIP-ChIP_GC-B_Human1.90863022
15FLI1_27457419_Chip-Seq_LIVER_Mouse1.58874018
16NANOG_18555785_Chip-Seq_ESCs_Mouse1.57333425
17ZNF274_21170338_ChIP-Seq_K562_Hela1.54148030
18CDX2_19796622_ChIP-Seq_MESCs_Mouse1.52717322
19TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.52710009
20VDR_22108803_ChIP-Seq_LS180_Human1.52450018
21* NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.52184429
22* NRF2_20460467_ChIP-Seq_MEFs_Mouse1.52184429
23EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.49210977
24PCGF2_27294783_Chip-Seq_ESCs_Mouse1.48976635
25* EZH2_27294783_Chip-Seq_NPCs_Mouse1.46132109
26NFE2_27457419_Chip-Seq_LIVER_Mouse1.45971375
27FOXA2_19822575_ChIP-Seq_HepG2_Human1.45450134
28IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.45366292
29ER_23166858_ChIP-Seq_MCF-7_Human1.42346597
30CDX2_22108803_ChIP-Seq_LS180_Human1.42248948
31TCF7L2_21901280_ChIP-Seq_H4IIE_Rat1.41577830
32SUZ12_18555785_Chip-Seq_ESCs_Mouse1.41239985
33TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.40308371
34IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.38870690
35CBP_20019798_ChIP-Seq_JUKART_Human1.38870690
36* EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.37923786
37GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.36970997
38STAT3_18555785_Chip-Seq_ESCs_Mouse1.36123030
39CMYC_18555785_Chip-Seq_ESCs_Mouse1.36092182
40THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.35369365
41RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.34684975
42P53_22387025_ChIP-Seq_ESCs_Mouse1.34398706
43* OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.32559770
44E2F1_18555785_Chip-Seq_ESCs_Mouse1.31307695
45SMAD_19615063_ChIP-ChIP_OVARY_Human1.31036879
46SOX2_18555785_Chip-Seq_ESCs_Mouse1.30777565
47IGF1R_20145208_ChIP-Seq_DFB_Human1.30637192
48FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.30458183
49FUS_26573619_Chip-Seq_HEK293_Human1.28402339
50GBX2_23144817_ChIP-Seq_PC3_Human1.28002513
51SMAD3_21741376_ChIP-Seq_EPCs_Human1.26938851
52ZNF217_24962896_ChIP-Seq_MCF-7_Human1.26646967
53UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.25924845
54* SOX2_19829295_ChIP-Seq_ESCs_Human1.25690775
55* NANOG_19829295_ChIP-Seq_ESCs_Human1.25690775
56* CRX_20693478_ChIP-Seq_RETINA_Mouse1.24947055
57ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.24505262
58STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.23989432
59* STAT3_23295773_ChIP-Seq_U87_Human1.23591121
60MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.23544603
61* CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.23139621
62P300_18555785_Chip-Seq_ESCs_Mouse1.22505319
63* AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.21536293
64GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.21052892
65BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.20621513
66FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.20509213
67EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse1.20278509
68PIAS1_25552417_ChIP-Seq_VCAP_Human1.19582604
69CTBP1_25329375_ChIP-Seq_LNCAP_Human1.19484211
70SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.19083628
71* FOXM1_26456572_ChIP-Seq_MCF-7_Human1.16954413
72* PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.16248886
73NR3C1_21868756_ChIP-Seq_MCF10A_Human1.14287598
74KLF5_20875108_ChIP-Seq_MESCs_Mouse1.14085905
75CLOCK_20551151_ChIP-Seq_293T_Human1.13794048
76RARG_19884340_ChIP-ChIP_MEFs_Mouse1.13182876
77TCF4_22108803_ChIP-Seq_LS180_Human1.12953840
78NMYC_18555785_Chip-Seq_ESCs_Mouse1.12034726
79CTCF_18555785_Chip-Seq_ESCs_Mouse1.11451430
80OCT4_18555785_Chip-Seq_ESCs_Mouse1.11098761
81ESR2_21235772_ChIP-Seq_MCF-7_Human1.10958589
82* RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.09683837
83PU1_27457419_Chip-Seq_LIVER_Mouse1.08436638
84IRF8_21731497_ChIP-ChIP_J774_Mouse1.07866175
85NR3C1_23031785_ChIP-Seq_PC12_Mouse1.07028795
86* OCT4_21477851_ChIP-Seq_ESCs_Mouse1.05632135
87TAF15_26573619_Chip-Seq_HEK293_Human1.05065895
88* TCF4_23295773_ChIP-Seq_U87_Human1.04695366
89BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.04580062
90* IRF8_27001747_Chip-Seq_BMDM_Mouse1.03413106
91HTT_18923047_ChIP-ChIP_STHdh_Human1.03384932
92* STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.02207637
93HNF4A_19822575_ChIP-Seq_HepG2_Human1.01305294
94CJUN_26792858_Chip-Seq_BT549_Human1.00971741
95CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.00694905
96* SOX2_20726797_ChIP-Seq_SW620_Human0.98890896
97GATA1_22025678_ChIP-Seq_K562_Human0.97554609
98TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse0.97479279
99SMAD4_21799915_ChIP-Seq_A2780_Human0.95254625
100ESR1_21235772_ChIP-Seq_MCF-7_Human0.95041646
101* SUZ12_18555785_ChIP-Seq_MESCs_Mouse0.94016073
102AR_21572438_ChIP-Seq_LNCaP_Human0.93755810
103SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse0.93348385
104* SUZ12_20075857_ChIP-Seq_MESCs_Mouse0.93279624
105HNF4A_19761587_ChIP-ChIP_CACO-2_Human0.91892530
106BCAT_22108803_ChIP-Seq_LS180_Human0.91165813
107PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse0.90906909
108CTBP2_25329375_ChIP-Seq_LNCAP_Human0.90176132
109TP53_18474530_ChIP-ChIP_U2OS_Human0.89960409
110* SUZ12_18974828_ChIP-Seq_MESCs_Mouse0.88565586
111* MTF2_20144788_ChIP-Seq_MESCs_Mouse0.88564270
112AR_21915096_ChIP-Seq_LNCaP-1F5_Human0.88188818
113VDR_24787735_ChIP-Seq_THP-1_Human0.86577585
114AR_25329375_ChIP-Seq_VCAP_Human0.83540292
115* SUZ12_18692474_ChIP-Seq_MESCs_Mouse0.83506391
116* GATA2_21666600_ChIP-Seq_HMVEC_Human0.83337624
117SALL4_18804426_ChIP-ChIP_XEN_Mouse0.82687531
118PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human0.82185497
119SUZ12_16625203_ChIP-ChIP_MESCs_Mouse0.81958797
120ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.81311037
121P300_19829295_ChIP-Seq_ESCs_Human0.81302155
122TP63_23658742_ChIP-Seq_EP156T_Human0.80795126
123PPAR_26484153_Chip-Seq_NCI-H1993_Human0.80555010
124NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse0.80063804
125AHR_22903824_ChIP-Seq_MCF-7_Human0.80056610
126CEBPD_23245923_ChIP-Seq_MEFs_Mouse0.78682486
127* SOX2_27498859_Chip-Seq_STOMACH_Mouse0.76667655
128FOXO3_23340844_ChIP-Seq_DLD1_Human0.76086098
129CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse0.75605599
130CDX2_20551321_ChIP-Seq_CACO-2_Human0.74992344
131SMARCD1_25818293_ChIP-Seq_ESCs_Mouse0.74990296
132ARNT_22903824_ChIP-Seq_MCF-7_Human0.74589985
133TFAP2C_20629094_ChIP-Seq_MCF-7_Human0.73845720
134SMAD2/3_21741376_ChIP-Seq_EPCs_Human0.73813055
135ZFP57_27257070_Chip-Seq_ESCs_Mouse0.73490387
136GATA4_25053715_ChIP-Seq_YYC3_Human0.72180057
137RXR_22108803_ChIP-Seq_LS180_Human0.71665523
138SOX2_21211035_ChIP-Seq_LN229_Gbm0.71115345
139TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.70510265
140TP53_16413492_ChIP-PET_HCT116_Human0.69946560
141POU3F2_20337985_ChIP-ChIP_501MEL_Human0.69645112
142SUZ12_27294783_Chip-Seq_NPCs_Mouse0.69387279
143ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.69370247
144TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.68870367
145ESR1_20079471_ChIP-ChIP_T-47D_Human0.68679271
146* SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.68298116
147KDM2B_26808549_Chip-Seq_REH_Human0.67534521
148PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.67328927
149SMAD4_21741376_ChIP-Seq_HESCs_Human0.66806220
150SUZ12_18692474_ChIP-Seq_MEFs_Mouse0.66663117
151MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human0.66435258

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005360_urolithiasis6.84251511
2MP0002139_abnormal_hepatobiliary_system6.82009819
3MP0005085_abnormal_gallbladder_physiolo5.08049605
4MP0005365_abnormal_bile_salt4.76631831
5MP0008875_abnormal_xenobiotic_pharmacok3.79085880
6MP0003252_abnormal_bile_duct3.51073228
7MP0010329_abnormal_lipoprotein_level3.00743603
8MP0003195_calcinosis2.99108363
9MP0009840_abnormal_foam_cell2.72993134
10MP0003806_abnormal_nucleotide_metabolis2.53876611
11MP0003191_abnormal_cellular_cholesterol2.52046316
12MP0005332_abnormal_amino_acid2.42317191
13MP0002837_dystrophic_cardiac_calcinosis2.38990066
14MP0001666_abnormal_nutrient_absorption2.30667924
15MP0005083_abnormal_biliary_tract2.27609439
16MP0005379_endocrine/exocrine_gland_phen2.19051236
17MP0002138_abnormal_hepatobiliary_system2.04938473
18MP0006054_spinal_hemorrhage2.04377424
19MP0002163_abnormal_gland_morphology1.95826915
20MP0000604_amyloidosis1.90985091
21MP0003183_abnormal_peptide_metabolism1.86339156
22MP0004019_abnormal_vitamin_homeostasis1.80711148
23MP0000609_abnormal_liver_physiology1.77390102
24MP0002118_abnormal_lipid_homeostasis1.73409605
25MP0003705_abnormal_hypodermis_morpholog1.72047746
26MP0003868_abnormal_feces_composition1.67685984
27MP0008438_abnormal_cutaneous_collagen1.64577195
28MP0005319_abnormal_enzyme/_coenzyme1.60590189
29MP0009764_decreased_sensitivity_to1.57642343
30MP0002148_abnormal_hypersensitivity_rea1.55896433
31MP0010678_abnormal_skin_adnexa1.53234842
32MP0003950_abnormal_plasma_membrane1.49568649
33MP0002909_abnormal_adrenal_gland1.44669002
34MP0005584_abnormal_enzyme/coenzyme_acti1.37256926
35MP0005058_abnormal_lysosome_morphology1.35114398
36MP0009697_abnormal_copulation1.33256966
37MP0002693_abnormal_pancreas_physiology1.29180694
38MP0004043_abnormal_pH_regulation1.28694337
39MP0002876_abnormal_thyroid_physiology1.27976275
40MP0002254_reproductive_system_inflammat1.25205896
41MP0001944_abnormal_pancreas_morphology1.18697421
42MP0009643_abnormal_urine_homeostasis1.18408742
43MP0003436_decreased_susceptibility_to1.18090078
44MP0004510_myositis1.13995185
45MP0003656_abnormal_erythrocyte_physiolo1.13897118
46MP0008469_abnormal_protein_level1.11130348
47MP0005167_abnormal_blood-brain_barrier1.10464941
48MP0003303_peritoneal_inflammation1.08345018
49MP0003690_abnormal_glial_cell1.08070549
50MP0006082_CNS_inflammation1.06961725
51MP0003329_amyloid_beta_deposits1.04312517
52MP0005646_abnormal_pituitary_gland1.00791945
53MP0009780_abnormal_chondrocyte_physiolo1.00469070
54MP0003724_increased_susceptibility_to0.99621763
55MP0005166_decreased_susceptibility_to0.99594117
56MP0005310_abnormal_salivary_gland0.97199432
57MP0010386_abnormal_urinary_bladder0.95804507
58MP0005647_abnormal_sex_gland0.95754160
59MP0001764_abnormal_homeostasis0.94052367
60MP0000569_abnormal_digit_pigmentation0.93795634
61MP0009763_increased_sensitivity_to0.92214346
62MP0001756_abnormal_urination0.91367106
63MP0000343_altered_response_to0.91013971
64MP0009046_muscle_twitch0.90864541
65MP0010352_gastrointestinal_tract_polyps0.90783296
66MP0000538_abnormal_urinary_bladder0.90331582
67MP0001790_abnormal_immune_system0.89761765
68MP0005387_immune_system_phenotype0.89761765
69MP0005535_abnormal_body_temperature0.88899712
70MP0005636_abnormal_mineral_homeostasis0.88838511
71MP0003075_altered_response_to0.87603079
72MP0000598_abnormal_liver_morphology0.87001299
73MP0001533_abnormal_skeleton_physiology0.86951282
74MP0009384_cardiac_valve_regurgitation0.86728994
75MP0003879_abnormal_hair_cell0.86031847
76MP0003300_gastrointestinal_ulcer0.85256561
77MP0009642_abnormal_blood_homeostasis0.84835549
78MP0004858_abnormal_nervous_system0.84732280
79MP0005084_abnormal_gallbladder_morpholo0.84102522
80MP0005220_abnormal_exocrine_pancreas0.82273375
81MP0004130_abnormal_muscle_cell0.81600903
82MP0005164_abnormal_response_to0.81262337
83MP0005464_abnormal_platelet_physiology0.80841076
84MP0003172_abnormal_lysosome_physiology0.80257219
85MP0002332_abnormal_exercise_endurance0.80016106
86MP0002168_other_aberrant_phenotype0.78547600
87MP0002090_abnormal_vision0.78300989
88MP0002295_abnormal_pulmonary_circulatio0.78229606
89MP0002078_abnormal_glucose_homeostasis0.77335880
90MP0005257_abnormal_intraocular_pressure0.76990225
91MP0010368_abnormal_lymphatic_system0.74395362
92MP0002419_abnormal_innate_immunity0.73636364
93MP0000516_abnormal_urinary_system0.73323868
94MP0005367_renal/urinary_system_phenotyp0.73323868
95MP0009765_abnormal_xenobiotic_induced0.72800153
96MP0002136_abnormal_kidney_physiology0.72292754
97MP0005410_abnormal_fertilization0.70250276
98MP0001984_abnormal_olfaction0.70211865
99MP0002896_abnormal_bone_mineralization0.67777010
100MP0005334_abnormal_fat_pad0.65889202
101MP0005165_increased_susceptibility_to0.65805454
102MP0001501_abnormal_sleep_pattern0.65425056
103MP0005275_abnormal_skin_tensile0.65325351
104MP0003011_delayed_dark_adaptation0.64025584
105MP0002998_abnormal_bone_remodeling0.63876718
106MP0005551_abnormal_eye_electrophysiolog0.63632074
107MP0005448_abnormal_energy_balance0.62192600
108MP0003186_abnormal_redox_activity0.61710882
109MP0003953_abnormal_hormone_level0.60456702
110MP0008872_abnormal_physiological_respon0.60141108
111MP0005395_other_phenotype0.60111758
112MP0009785_altered_susceptibility_to0.59615337
113MP0002971_abnormal_brown_adipose0.58644655
114MP0002928_abnormal_bile_duct0.58518050
115MP0000427_abnormal_hair_cycle0.58461307
116MP0001845_abnormal_inflammatory_respons0.57987709
117MP0005376_homeostasis/metabolism_phenot0.57904837
118MP0005000_abnormal_immune_tolerance0.57880265
119MP0005503_abnormal_tendon_morphology0.57819398
120MP0008874_decreased_physiological_sensi0.57606270
121MP0000685_abnormal_immune_system0.56768211
122MP0009745_abnormal_behavioral_response0.56750820
123MP0001542_abnormal_bone_strength0.56641589
124MP0000230_abnormal_systemic_arterial0.55770185
125MP0001881_abnormal_mammary_gland0.54825102
126MP0001661_extended_life_span0.54346853
127MP0001765_abnormal_ion_homeostasis0.53258521
128MP0005408_hypopigmentation0.53183905
129MP0003633_abnormal_nervous_system0.53156438
130MP0010234_abnormal_vibrissa_follicle0.52446705
131MP0004947_skin_inflammation0.51909621
132MP0003091_abnormal_cell_migration0.51332910
133MP0001835_abnormal_antigen_presentation0.51104565
134MP0005197_abnormal_uvea_morphology0.50111887
135MP0004883_abnormal_blood_vessel0.49901056

Predicted human phenotypes

RankGene SetZ-score
1Complement deficiency (HP:0004431)6.08420453
2Deep venous thrombosis (HP:0002625)6.06088729
3Intrahepatic cholestasis (HP:0001406)5.65568055
4Prolonged partial thromboplastin time (HP:0003645)5.28824006
5Abnormality of aromatic amino acid family metabolism (HP:0004338)5.15040713
6Xanthomatosis (HP:0000991)5.09772858
7Abnormality of monocarboxylic acid metabolism (HP:0010996)4.92495022
8Abnormality of glycolipid metabolism (HP:0010969)4.82561204
9Abnormality of liposaccharide metabolism (HP:0010968)4.82561204
10Abnormality of glycosphingolipid metabolism (HP:0004343)4.82561204
11Abnormality of complement system (HP:0005339)4.65220077
12Hypobetalipoproteinemia (HP:0003563)4.60648565
13Abnormality of the common coagulation pathway (HP:0010990)4.57066870
14Joint hemorrhage (HP:0005261)4.26853366
15Hyperlipoproteinemia (HP:0010980)4.10155486
16Abnormality of glutamine family amino acid metabolism (HP:0010902)4.06184221
17Recurrent gram-negative bacterial infections (HP:0005420)4.01012229
18Epidermoid cyst (HP:0200040)3.88301895
19Systemic lupus erythematosus (HP:0002725)3.76279417
20Myocardial infarction (HP:0001658)3.71500644
21Spontaneous abortion (HP:0005268)3.68292029
22Hypolipoproteinemia (HP:0010981)3.63522374
23Conjugated hyperbilirubinemia (HP:0002908)3.59141209
24Fat malabsorption (HP:0002630)3.56674856
25Abnormality of the intrinsic pathway (HP:0010989)3.52300808
26Hypoalphalipoproteinemia (HP:0003233)3.32503320
27Abnormality of the level of lipoprotein cholesterol (HP:0010979)3.32315883
28Generalized aminoaciduria (HP:0002909)3.27793019
29Abnormality of sulfur amino acid metabolism (HP:0004339)3.22661971
30Glomerulonephritis (HP:0000099)3.20774888
31Hypothermia (HP:0002045)3.16397543
32Abnormality of vitamin metabolism (HP:0100508)3.11018567
33Hyperammonemia (HP:0001987)3.06662316
34Ketosis (HP:0001946)3.00516599
35Hematochezia (HP:0002573)3.00220157
36Abnormality of vitamin B metabolism (HP:0004340)2.94729814
37Hypercholesterolemia (HP:0003124)2.91089648
38Abnormality of aspartate family amino acid metabolism (HP:0010899)2.90730958
39Sensorimotor neuropathy (HP:0007141)2.88401668
40Skin nodule (HP:0200036)2.87839567
41Amyloidosis (HP:0011034)2.85777133
42Hyperglycinemia (HP:0002154)2.84629618
43Mitral stenosis (HP:0001718)2.77841653
44Mutism (HP:0002300)2.72174638
45Nuclear cataract (HP:0100018)2.71055380
46Disinhibition (HP:0000734)2.66887535
47Methylmalonic acidemia (HP:0002912)2.66169446
48Increased CSF protein (HP:0002922)2.65041470
49Glycosuria (HP:0003076)2.57846264
50Abnormality of urine glucose concentration (HP:0011016)2.57846264
51Abnormality of methionine metabolism (HP:0010901)2.57100717
52Gingival bleeding (HP:0000225)2.56331904
53Steatorrhea (HP:0002570)2.53380386
54Loss of speech (HP:0002371)2.49659788
55Nephritis (HP:0000123)2.49110598
56Hydroxyprolinuria (HP:0003080)2.45589480
57Abnormality of proline metabolism (HP:0010907)2.45589480
58Congenital sensorineural hearing impairment (HP:0008527)2.42682543
59Protuberant abdomen (HP:0001538)2.40560986
60Hepatocellular carcinoma (HP:0001402)2.38283593
61Azoospermia (HP:0000027)2.37215206
62Abnormality of glycine metabolism (HP:0010895)2.36954734
63Abnormality of serine family amino acid metabolism (HP:0010894)2.36954734
64Hyperglycinuria (HP:0003108)2.34151009
65Peritonitis (HP:0002586)2.31348006
66Methylmalonic aciduria (HP:0012120)2.30986842
67Ketoacidosis (HP:0001993)2.30203101
68Abnormality of purine metabolism (HP:0004352)2.30188436
69Thyroiditis (HP:0100646)2.29373332
70Abnormality of nucleobase metabolism (HP:0010932)2.29131740
71Urinary glycosaminoglycan excretion (HP:0003541)2.27188979
72Mucopolysacchariduria (HP:0008155)2.27188979
73Abnormality of pyrimidine metabolism (HP:0004353)2.27018349
74Proximal tubulopathy (HP:0000114)2.25410738
75Cholecystitis (HP:0001082)2.25001919
76Abnormal gallbladder physiology (HP:0012438)2.25001919
77Hypoglycemic coma (HP:0001325)2.23948150
78Conjunctival hamartoma (HP:0100780)2.23832478
79Vascular calcification (HP:0004934)2.23719280
80Hyperglycemia (HP:0003074)2.19997007
81Cardiovascular calcification (HP:0011915)2.19856706
82Exocrine pancreatic insufficiency (HP:0001738)2.16423045
83Abnormality of polysaccharide metabolism (HP:0011012)2.16404284
84Abnormality of glycosaminoglycan metabolism (HP:0004371)2.16404284
85Abnormality of mucopolysaccharide metabolism (HP:0011020)2.16404284
86Renal cortical cysts (HP:0000803)2.16158698
87Hemiparesis (HP:0001269)2.16108832
88Late onset (HP:0003584)2.14423454
89Progressive macrocephaly (HP:0004481)2.14421627
90Menorrhagia (HP:0000132)2.12873916
91Malnutrition (HP:0004395)2.12809488
92Hyperbilirubinemia (HP:0002904)2.09023065
93Abnormality of long-chain fatty-acid metabolism (HP:0010964)2.06544497
94Thrombophlebitis (HP:0004418)2.05661554
95Abnormality of the vitamin B12 metabolism (HP:0004341)2.02386575
96Esophageal varix (HP:0002040)2.02378584
97Acanthocytosis (HP:0001927)2.01839539
98Abnormality of fatty-acid metabolism (HP:0004359)2.00469961
99Hyperventilation (HP:0002883)1.98284032
100Vacuolated lymphocytes (HP:0001922)1.97620810
101Abnormal gallbladder morphology (HP:0012437)1.97482921
102Dysostosis multiplex (HP:0000943)1.96626596
103Stomatitis (HP:0010280)1.96502666
104Symptomatic seizures (HP:0011145)1.95180155
105Progressive neurologic deterioration (HP:0002344)1.94727585
106Status epilepticus (HP:0002133)1.94103991
107Axonal loss (HP:0003447)1.91491018
108Cholelithiasis (HP:0001081)1.90633593
109Hamartoma of the eye (HP:0010568)1.89871886
110Prolonged neonatal jaundice (HP:0006579)1.89188523
111Abnormality of the renal cortex (HP:0011035)1.87862977
112Albinism (HP:0001022)1.87857564
113Agitation (HP:0000713)1.87601872
114Hypophosphatemic rickets (HP:0004912)1.86900006
115Zonular cataract (HP:0010920)1.86517035
116Hypoglycemic seizures (HP:0002173)1.86242918
117Postural tremor (HP:0002174)1.86229071
118Irritability (HP:0000737)1.85599463
119Elevated circulating parathyroid hormone (PTH) level (HP:0003165)1.85531787
120Tongue fasciculations (HP:0001308)1.84315766
121Neonatal onset (HP:0003623)1.83885529
122Muscular hypotonia of the trunk (HP:0008936)1.82946120
123Lethargy (HP:0001254)1.82186783
124Abnormality of the lumbar spine (HP:0100712)1.81824540
125Stroke (HP:0001297)1.81373374
126Bone cyst (HP:0012062)1.79935328
127Pancreatitis (HP:0001733)1.79664023
128Pigmentary retinal degeneration (HP:0001146)1.78943934
129Hemorrhage of the eye (HP:0011885)1.77481989
130Metaphyseal irregularity (HP:0003025)1.77352843
1313-Methylglutaconic aciduria (HP:0003535)1.76511696
132Hypokinesia (HP:0002375)1.76031239
133Abnormality of serum amino acid levels (HP:0003112)1.73470322
134Gout (HP:0001997)1.72641484
135Medial flaring of the eyebrow (HP:0010747)1.71811308
136Large for gestational age (HP:0001520)1.71377250
137Metabolic acidosis (HP:0001942)1.70735783
138Abnormal enzyme/coenzyme activity (HP:0012379)1.70603468
139Acute necrotizing encephalopathy (HP:0006965)1.70531156
140Joint swelling (HP:0001386)1.70250630
141Intention tremor (HP:0002080)1.70078451
142Inappropriate behavior (HP:0000719)1.69905247
143Metaphyseal dysplasia (HP:0100255)1.69882019
144Nausea (HP:0002018)1.69226329
145Abnormal tarsal ossification (HP:0008369)1.68772121
146Hyperinsulinemic hypoglycemia (HP:0000825)1.68558243
147Cardiomegaly (HP:0001640)1.68035423
148Arthropathy (HP:0003040)1.67257712
149Upper motor neuron abnormality (HP:0002127)1.67150364
150Abnormality of the gallbladder (HP:0005264)1.65786892
151Ectopia lentis (HP:0001083)1.64690147
152Elevated alkaline phosphatase (HP:0003155)1.64208915
153Lower limb hyperreflexia (HP:0002395)1.63403710
154Rickets (HP:0002748)1.61907434
155Abnormal delivery (HP:0001787)1.61579685
156Abnormality of transition element cation homeostasis (HP:0011030)1.60398948
157Tetraparesis (HP:0002273)1.59774778
158Spastic diplegia (HP:0001264)1.59419555

Predicted kinase interactions (KEA)

RankGene SetZ-score
1ERN13.97401305
2TAOK33.40748648
3FRK3.33362575
4MST42.97739850
5TRIM282.69294378
6MAP4K22.62649620
7ACVR1B2.61599430
8MAP3K122.60855006
9ERBB42.58467314
10ADRBK22.48444209
11FGFR42.37700165
12BCKDK2.25814059
13INSRR2.21778138
14BCR2.11465487
15SIK12.10505661
16AKT32.10044836
17ERBB31.98441336
18GRK11.92546238
19LATS11.89152322
20MAP3K141.85929002
21MAP2K41.84161542
22DAPK21.75419786
23GRK71.74846924
24NEK91.73909459
25MST1R1.72361327
26JAK11.71815656
27STK241.71356647
28TYK21.70406681
29EPHA31.66408632
30BMPR1B1.60138779
31OXSR11.59451009
32PIK3CG1.57579813
33STK391.56317586
34MAP3K21.49114739
35TBK11.46093784
36NTRK11.46023370
37CSNK1G11.43520158
38MAP3K131.42371899
39CASK1.37126257
40RIPK41.33972774
41EIF2AK31.29137707
42MAP3K31.26193540
43CSNK1G21.24728414
44LMTK21.21405348
45TGFBR21.20051455
46CSNK1G31.19733123
47DDR21.18966800
48MAP3K91.17742009
49LATS21.17332242
50RIPK11.15562108
51TRPM71.13939987
52PTK61.10187362
53IRAK31.07166285
54PHKG11.04825555
55PHKG21.04825555
56SIK31.04446830
57SGK30.98451069
58PINK10.98343529
59CSNK1A1L0.97434698
60JAK20.96772907
61RET0.96488258
62MAP3K40.96004325
63MAP2K70.95142287
64ABL20.94969862
65TNIK0.93922131
66WNK30.91952174
67SGK20.91605921
68MAP2K60.91563439
69NTRK30.91382379
70STK38L0.91147042
71FER0.90327434
72NLK0.88375021
73CAMK1D0.88064810
74PRKCZ0.87972790
75TRIB30.85831601
76TAOK10.85504739
77FGFR30.85256594
78MAPK110.84025742
79LIMK10.82566777
80PRKCH0.82137913
81CAMKK10.81677306
82BMPR20.80030569
83TXK0.77983381
84MAP2K10.77838892
85PLK20.77027374
86MARK10.76170942
87EPHB10.75645006
88PDK20.72090410
89STK30.71458964
90BMX0.71091783
91PAK30.68265702
92PTK20.67328637
93KSR20.65586062
94MATK0.64726519
95SGK4940.64635961
96SGK2230.64635961
97PRKCG0.64613465
98PRKAA20.63221102
99PTK2B0.62771977
100PIM20.62228712
101PRKCE0.61053590
102CAMK1G0.60941873
103PDPK10.59201581
104ERBB20.59026214
105CHUK0.58684527
106MINK10.58612192
107MAP3K10.56739355
108GSK3A0.56301376
109CAMKK20.54878167
110JAK30.54498375
111CSF1R0.54282202
112EGFR0.53690711
113CSK0.52458896
114KIT0.51275974
115MAPK120.51257205
116PDGFRA0.51027840
117PRKACG0.50954058
118PAK60.50917538
119STK380.50897084
120PRKAA10.50430820
121IKBKB0.49613576
122MAP3K70.48968722
123GRK60.48282699
124IGF1R0.47235021
125PRKG20.46439189
126CAMK2G0.45867755
127ROCK10.45700660
128WNK40.44913179
129IKBKE0.44870561
130CAMK2D0.44686303
131PIK3CA0.43497181
132PRKCI0.42955043
133PKN10.41943715
134PRKCQ0.41376222
135CSNK1A10.41192188
136MAP3K50.40557279
137FGR0.40012118
138IRAK10.39992527
139CAMK2A0.39931971
140FGFR20.39739473
141FLT30.39616448
142EPHA40.39317864
143MYLK0.38977046
144MAPK130.38648384
145ABL10.37268242
146TESK10.37264672
147EIF2AK10.37159711
148ADRBK10.37071299
149DAPK10.33479912
150PRKG10.32720575
151PRKCA0.28715953
152MET0.27162740

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary bile acid biosynthesis_Homo sapiens_hsa001204.29601491
2Complement and coagulation cascades_Homo sapiens_hsa046103.30492321
3Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004003.16939158
4Nitrogen metabolism_Homo sapiens_hsa009103.09875531
5Arginine biosynthesis_Homo sapiens_hsa002203.01550694
6Ascorbate and aldarate metabolism_Homo sapiens_hsa000532.88633046
7Staphylococcus aureus infection_Homo sapiens_hsa051502.43794476
8Tryptophan metabolism_Homo sapiens_hsa003802.37721388
9Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010402.15002535
10Pentose and glucuronate interconversions_Homo sapiens_hsa000401.95683309
11Fatty acid degradation_Homo sapiens_hsa000711.95316035
12Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.89203691
13Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.84289846
14Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.77534954
15Peroxisome_Homo sapiens_hsa041461.75714705
16PPAR signaling pathway_Homo sapiens_hsa033201.75406209
17Protein export_Homo sapiens_hsa030601.71109606
18Butanoate metabolism_Homo sapiens_hsa006501.69880968
19Bile secretion_Homo sapiens_hsa049761.69561722
20Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.67689912
21Histidine metabolism_Homo sapiens_hsa003401.58589748
22Sulfur metabolism_Homo sapiens_hsa009201.54094405
23Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.53155842
24Steroid hormone biosynthesis_Homo sapiens_hsa001401.51689392
25Caffeine metabolism_Homo sapiens_hsa002321.46785133
26Type I diabetes mellitus_Homo sapiens_hsa049401.44597218
27Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.43933605
28Chemical carcinogenesis_Homo sapiens_hsa052041.43752179
29Fatty acid metabolism_Homo sapiens_hsa012121.37222185
30Starch and sucrose metabolism_Homo sapiens_hsa005001.32271084
31Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.30464014
32Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.29776816
33Propanoate metabolism_Homo sapiens_hsa006401.28102074
34Retinol metabolism_Homo sapiens_hsa008301.26981047
35Phenylalanine metabolism_Homo sapiens_hsa003601.26875608
36Linoleic acid metabolism_Homo sapiens_hsa005911.26760379
37Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.24139747
38Sphingolipid metabolism_Homo sapiens_hsa006001.23313332
39Steroid biosynthesis_Homo sapiens_hsa001001.22495079
40beta-Alanine metabolism_Homo sapiens_hsa004101.22488014
41Tyrosine metabolism_Homo sapiens_hsa003501.20168902
42Fat digestion and absorption_Homo sapiens_hsa049751.18226256
43Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.16106528
44Asthma_Homo sapiens_hsa053101.15565700
45Drug metabolism - other enzymes_Homo sapiens_hsa009831.13132183
46Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.08276231
47Vitamin digestion and absorption_Homo sapiens_hsa049771.07629417
48ABC transporters_Homo sapiens_hsa020101.05790533
49Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.05171896
50Intestinal immune network for IgA production_Homo sapiens_hsa046721.00896506
51Selenocompound metabolism_Homo sapiens_hsa004501.00192913
52Prion diseases_Homo sapiens_hsa050200.97039417
53Vibrio cholerae infection_Homo sapiens_hsa051100.91279629
54Legionellosis_Homo sapiens_hsa051340.90443623
55Maturity onset diabetes of the young_Homo sapiens_hsa049500.89133087
56Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.88498647
572-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.87170700
58Pyruvate metabolism_Homo sapiens_hsa006200.85062612
59Allograft rejection_Homo sapiens_hsa053300.84336667
60Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.83484506
61Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.80063294
62Oxidative phosphorylation_Homo sapiens_hsa001900.78892876
63Folate biosynthesis_Homo sapiens_hsa007900.78835275
64Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.78202487
65Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.77526760
66SNARE interactions in vesicular transport_Homo sapiens_hsa041300.73549792
67Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.72104341
68Circadian rhythm_Homo sapiens_hsa047100.70971808
69Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.69937813
70Ether lipid metabolism_Homo sapiens_hsa005650.69275019
71Autoimmune thyroid disease_Homo sapiens_hsa053200.68158466
72Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.67880912
73alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.66561472
74Arachidonic acid metabolism_Homo sapiens_hsa005900.66127929
75Cysteine and methionine metabolism_Homo sapiens_hsa002700.65979431
76Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.65377117
77Graft-versus-host disease_Homo sapiens_hsa053320.63124610
78Lysosome_Homo sapiens_hsa041420.61236600
79NOD-like receptor signaling pathway_Homo sapiens_hsa046210.59937354
80Arginine and proline metabolism_Homo sapiens_hsa003300.59519441
81Vitamin B6 metabolism_Homo sapiens_hsa007500.58449849
82Fatty acid elongation_Homo sapiens_hsa000620.55814959
83Glycerolipid metabolism_Homo sapiens_hsa005610.54690211
84Lysine degradation_Homo sapiens_hsa003100.54496125
85Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.53885166
86Carbon metabolism_Homo sapiens_hsa012000.50993759
87Biosynthesis of amino acids_Homo sapiens_hsa012300.50784736
88Insulin secretion_Homo sapiens_hsa049110.50677212
89Glycosaminoglycan degradation_Homo sapiens_hsa005310.49460612
90Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.49444131
91Cyanoamino acid metabolism_Homo sapiens_hsa004600.45160131
92Pancreatic secretion_Homo sapiens_hsa049720.44604073
93NF-kappa B signaling pathway_Homo sapiens_hsa040640.44482040
94Renin-angiotensin system_Homo sapiens_hsa046140.44297531
95Fatty acid biosynthesis_Homo sapiens_hsa000610.43452671
96Phototransduction_Homo sapiens_hsa047440.42575075
97Salmonella infection_Homo sapiens_hsa051320.42172328
98Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.41806655
99Adipocytokine signaling pathway_Homo sapiens_hsa049200.41628487
100Phagosome_Homo sapiens_hsa041450.41066916
101Amoebiasis_Homo sapiens_hsa051460.39701464
102Insulin resistance_Homo sapiens_hsa049310.39195625
103Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.38021146
104Pertussis_Homo sapiens_hsa051330.34568691
105African trypanosomiasis_Homo sapiens_hsa051430.34499244
106Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.33945671
107Mineral absorption_Homo sapiens_hsa049780.30391594
108Synaptic vesicle cycle_Homo sapiens_hsa047210.30058508
109Toll-like receptor signaling pathway_Homo sapiens_hsa046200.27681470
110Fructose and mannose metabolism_Homo sapiens_hsa000510.26710040
111Collecting duct acid secretion_Homo sapiens_hsa049660.26361181
112Thyroid hormone synthesis_Homo sapiens_hsa049180.25979106
113Rheumatoid arthritis_Homo sapiens_hsa053230.25681485
114Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.25597664
115Type II diabetes mellitus_Homo sapiens_hsa049300.25461527
116Malaria_Homo sapiens_hsa051440.25163462
117Ovarian steroidogenesis_Homo sapiens_hsa049130.22016660
118Tuberculosis_Homo sapiens_hsa051520.21566688
119Protein digestion and absorption_Homo sapiens_hsa049740.20818013
120Sulfur relay system_Homo sapiens_hsa041220.20361616
121Glutathione metabolism_Homo sapiens_hsa004800.19459046
122Galactose metabolism_Homo sapiens_hsa000520.19442912
123Carbohydrate digestion and absorption_Homo sapiens_hsa049730.19367191
124Hepatitis C_Homo sapiens_hsa051600.16804932
125Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.16128925
126Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.15195456
127Metabolic pathways_Homo sapiens_hsa011000.15184137
128TNF signaling pathway_Homo sapiens_hsa046680.14565555
129Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.14565150
130Glycerophospholipid metabolism_Homo sapiens_hsa005640.14553299
131Leishmaniasis_Homo sapiens_hsa051400.13633601
132Other glycan degradation_Homo sapiens_hsa005110.10880750
133Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.10584098

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