SLC41A3

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1sarcomere organization (GO:0045214)6.84441034
2muscle filament sliding (GO:0030049)6.27287159
3actin-myosin filament sliding (GO:0033275)6.27287159
4positive regulation of ryanodine-sensitive calcium-release channel activity (GO:0060316)5.85216557
5myofibril assembly (GO:0030239)5.84075971
6regulation of skeletal muscle contraction (GO:0014819)5.75787531
7cardiac myofibril assembly (GO:0055003)5.66053278
8regulation of plasminogen activation (GO:0010755)5.59845355
9homocysteine metabolic process (GO:0050667)5.55809936
10regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum (GO:0010880)5.46106845
11tricarboxylic acid cycle (GO:0006099)5.46025768
12heme biosynthetic process (GO:0006783)5.43599605
13sarcoplasmic reticulum calcium ion transport (GO:0070296)5.30451512
14protoporphyrinogen IX metabolic process (GO:0046501)5.29891126
15porphyrin-containing compound biosynthetic process (GO:0006779)5.23515637
16regulation of relaxation of muscle (GO:1901077)5.18806109
17polyketide metabolic process (GO:0030638)5.17135225
18doxorubicin metabolic process (GO:0044598)5.17135225
19daunorubicin metabolic process (GO:0044597)5.17135225
20protoporphyrinogen IX biosynthetic process (GO:0006782)5.10790110
21actin-mediated cell contraction (GO:0070252)5.01058086
22synaptic vesicle docking involved in exocytosis (GO:0016081)4.93977760
23heart process (GO:0003015)4.93644681
24heart contraction (GO:0060047)4.93644681
25desmosome organization (GO:0002934)4.92608557
26cardiac muscle contraction (GO:0060048)4.91567948
27tetrapyrrole biosynthetic process (GO:0033014)4.87916205
28regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion (GO4.80460592
29regulation of cell communication by electrical coupling (GO:0010649)4.58420757
30synaptic vesicle maturation (GO:0016188)4.53358151
31plasma membrane repair (GO:0001778)4.46045099
32negative regulation of catenin import into nucleus (GO:0035414)4.43753889
33regulation of actin filament-based movement (GO:1903115)4.40592973
34glutamate secretion (GO:0014047)4.39420560
35oxidative phosphorylation (GO:0006119)4.38434628
36regulation of cardiac muscle contraction by calcium ion signaling (GO:0010882)4.35738891
37striated muscle contraction (GO:0006941)4.34509795
38heme metabolic process (GO:0042168)4.34021379
39skeletal muscle adaptation (GO:0043501)4.32034832
40negative regulation of potassium ion transmembrane transporter activity (GO:1901017)4.24347908
41regulation of ryanodine-sensitive calcium-release channel activity (GO:0060314)4.23341724
42cardiac muscle cell development (GO:0055013)4.20908927
43regulation of acetyl-CoA biosynthetic process from pyruvate (GO:0010510)4.11726955
44microtubule nucleation (GO:0007020)4.10364457
45sulfur amino acid catabolic process (GO:0000098)4.08887102
46oxygen transport (GO:0015671)4.07081742
47porphyrin-containing compound metabolic process (GO:0006778)4.04644346
48negative regulation of potassium ion transmembrane transport (GO:1901380)4.01949143
49actomyosin structure organization (GO:0031032)3.95850340
50response to stimulus involved in regulation of muscle adaptation (GO:0014874)3.94357124
51gas transport (GO:0015669)3.89341300
52skeletal muscle contraction (GO:0003009)3.88493618
53cardiac cell development (GO:0055006)3.87088271
54protein-chromophore linkage (GO:0018298)3.86801654
55synaptic vesicle exocytosis (GO:0016079)3.85468043
56mitochondrial ATP synthesis coupled proton transport (GO:0042776)3.79611157
57cellular response to zinc ion (GO:0071294)3.79521274
58regulation of striated muscle contraction (GO:0006942)3.78689394
59galactose metabolic process (GO:0006012)3.77781354
60carnitine shuttle (GO:0006853)3.76375156
61quinone biosynthetic process (GO:1901663)3.74799777
62ubiquinone biosynthetic process (GO:0006744)3.74799777
63regulation of acyl-CoA biosynthetic process (GO:0050812)3.71328978
64regulation of sarcomere organization (GO:0060297)3.68687646
65galactose catabolic process (GO:0019388)3.67343254
66cochlea development (GO:0090102)3.66313902
67white fat cell differentiation (GO:0050872)3.65971332
68NADH metabolic process (GO:0006734)3.64722696
69creatine metabolic process (GO:0006600)3.63740829
70innervation (GO:0060384)3.62232001
71striated muscle atrophy (GO:0014891)3.58808853
72cysteine metabolic process (GO:0006534)3.57362169
73cardiac muscle hypertrophy (GO:0003300)3.56112146
74respiratory electron transport chain (GO:0022904)3.54610602
75actin filament-based movement (GO:0030048)3.54522992
76mitochondrial electron transport, NADH to ubiquinone (GO:0006120)3.51037788
77regulation of short-term neuronal synaptic plasticity (GO:0048172)3.50768827
78regulation of ventricular cardiac muscle cell membrane repolarization (GO:0060307)3.48073184
79positive regulation of calcium ion-dependent exocytosis (GO:0045956)3.47861727
80pyrimidine ribonucleoside catabolic process (GO:0046133)3.46251982
81electron transport chain (GO:0022900)3.45951652
82oxaloacetate metabolic process (GO:0006107)3.45095139
83ATP synthesis coupled proton transport (GO:0015986)3.44847383
84energy coupled proton transport, down electrochemical gradient (GO:0015985)3.44847383
85striated muscle hypertrophy (GO:0014897)3.43589157
86negative regulation of cell size (GO:0045792)3.40540886
87regulation of synaptic vesicle exocytosis (GO:2000300)3.39680467
88negative regulation of cAMP-mediated signaling (GO:0043951)3.37722759
89primary amino compound metabolic process (GO:1901160)3.36858508
90carnitine transmembrane transport (GO:1902603)3.31596264
91regulation of cofactor metabolic process (GO:0051193)3.31125326
92regulation of coenzyme metabolic process (GO:0051196)3.31125326
93cardiac muscle tissue morphogenesis (GO:0055008)3.30415652
94protein retention in ER lumen (GO:0006621)3.27672151
95response to parathyroid hormone (GO:0071107)3.27485098
96peptidyl-proline hydroxylation (GO:0019511)3.26693235
97muscle atrophy (GO:0014889)3.25283028
98inner ear receptor cell development (GO:0060119)3.24895546
99RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)3.24425612
100tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)3.24425612
101erythrocyte maturation (GO:0043249)3.22625453
102phosphatidylglycerol biosynthetic process (GO:0006655)3.21417695
103muscle hypertrophy (GO:0014896)3.20676310
104gamma-aminobutyric acid signaling pathway (GO:0007214)3.18045424
105antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G3.17629565
106positive regulation of calcium ion transmembrane transporter activity (GO:1901021)3.17424412
107cell migration involved in heart development (GO:0060973)3.17286196
108erythrocyte development (GO:0048821)3.16814907
109positive regulation of synapse maturation (GO:0090129)3.16683434
110maintenance of protein localization in endoplasmic reticulum (GO:0035437)3.15207171
111purine nucleotide salvage (GO:0032261)3.14912586
112folic acid-containing compound biosynthetic process (GO:0009396)3.14589551
1132-oxoglutarate metabolic process (GO:0006103)3.13823774
114locomotory exploration behavior (GO:0035641)3.13708613
115striated muscle adaptation (GO:0014888)3.11346206
116regulation of ATP catabolic process (GO:1903289)3.10815115
117regulation of ATPase activity (GO:0043462)3.10815115
118cellular potassium ion homeostasis (GO:0030007)3.10675729
119adult heart development (GO:0007512)3.10647610
120ubiquinone metabolic process (GO:0006743)3.10431449
121fatty acid transmembrane transport (GO:1902001)3.08968324
1224-hydroxyproline metabolic process (GO:0019471)3.08924414
123postsynaptic membrane organization (GO:0001941)3.07163609
124neuronal ion channel clustering (GO:0045161)3.06785388
125sodium ion export (GO:0071436)3.05273823
126response to inactivity (GO:0014854)3.04498723
127regulation of sequestering of triglyceride (GO:0010889)3.03331926
128cerebellar granule cell differentiation (GO:0021707)3.02452585
129behavioral defense response (GO:0002209)3.02344142
130behavioral fear response (GO:0001662)3.02344142
131neurotransmitter secretion (GO:0007269)3.01912020
132positive regulation of cation channel activity (GO:2001259)3.00971339
133response to muscle activity (GO:0014850)2.99833144
134exploration behavior (GO:0035640)2.98826694
135aerobic respiration (GO:0009060)2.97166265
136tricarboxylic acid metabolic process (GO:0072350)2.94999263
137regulation of cardiac muscle contraction (GO:0055117)2.94903117
138amino-acid betaine transport (GO:0015838)2.94690892
139carnitine transport (GO:0015879)2.94690892
140regulation of tight junction assembly (GO:2000810)2.94478148
141negative regulation of chondrocyte differentiation (GO:0032331)2.93811694
142muscle tissue morphogenesis (GO:0060415)2.91997108
143muscle contraction (GO:0006936)2.91334566
144aminoglycoside antibiotic metabolic process (GO:0030647)2.89493198
145epithelial to mesenchymal transition involved in endocardial cushion formation (GO:0003198)2.89285112
146succinate metabolic process (GO:0006105)2.87390042
147glycogen catabolic process (GO:0005980)2.86880351
148heart trabecula formation (GO:0060347)2.86733973
149ventricular cardiac muscle tissue morphogenesis (GO:0055010)2.86142121
150COPII vesicle coating (GO:0048208)2.84934058
151regulation of female receptivity (GO:0045924)2.83613065
152neuronal action potential propagation (GO:0019227)2.82320263
153regulation of neuronal synaptic plasticity (GO:0048168)2.80198323
154negative regulation of Ras GTPase activity (GO:0034261)2.78081293
155regulation of synaptic vesicle transport (GO:1902803)2.75419493
156regulation of synapse maturation (GO:0090128)2.74431279
157positive regulation of endothelial cell differentiation (GO:0045603)2.70964485
158mating behavior (GO:0007617)2.65809912
159pteridine-containing compound biosynthetic process (GO:0042559)2.65684596
160fear response (GO:0042596)2.65074105
161growth hormone secretion (GO:0030252)2.62577948
162artery smooth muscle contraction (GO:0014824)2.61263998
163negative regulation of DNA biosynthetic process (GO:2000279)2.59611539
164vocalization behavior (GO:0071625)2.59234661
165protein hydroxylation (GO:0018126)2.57772082
166transferrin transport (GO:0033572)2.56653648
167histone H4-K12 acetylation (GO:0043983)2.55701432
168membrane depolarization during cardiac muscle cell action potential (GO:0086012)2.50361781
169regulation of vesicle fusion (GO:0031338)2.49821777
170neuromuscular process controlling balance (GO:0050885)2.48479414
171long term synaptic depression (GO:0060292)2.47632064
172cellular sodium ion homeostasis (GO:0006883)2.47512504
173dendritic spine organization (GO:0097061)2.47082265
174layer formation in cerebral cortex (GO:0021819)2.47077796
175negative regulation of keratinocyte proliferation (GO:0010839)2.44388983
176Golgi transport vesicle coating (GO:0048200)2.42614644
177COPI coating of Golgi vesicle (GO:0048205)2.42614644
178regulation of gonadotropin secretion (GO:0032276)2.41337668
179establishment of mitochondrion localization (GO:0051654)2.40864448
180synaptic vesicle endocytosis (GO:0048488)2.39938159
181positive regulation of excitatory postsynaptic membrane potential (GO:2000463)2.39785921
182cerebellar Purkinje cell layer development (GO:0021680)2.39438182
183ionotropic glutamate receptor signaling pathway (GO:0035235)2.37171225
184dicarboxylic acid biosynthetic process (GO:0043650)2.37028281
185negative regulation of blood vessel endothelial cell migration (GO:0043537)2.36422584
186ferric iron transport (GO:0015682)2.35148986
187trivalent inorganic cation transport (GO:0072512)2.35148986
188regulation of synaptic plasticity (GO:0048167)2.34766084
189cytoskeletal anchoring at plasma membrane (GO:0007016)2.34459592
190regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)2.33976104
191cAMP biosynthetic process (GO:0006171)2.29372113
192proline metabolic process (GO:0006560)2.28278955
193tonic smooth muscle contraction (GO:0014820)2.27943174
194retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)2.27899814
195phosphate ion transport (GO:0006817)2.27724477
196ATP hydrolysis coupled proton transport (GO:0015991)2.27453717
197energy coupled proton transmembrane transport, against electrochemical gradient (GO:0015988)2.27453717
198response to lipoprotein particle (GO:0055094)2.26634839
199regulation of long-term neuronal synaptic plasticity (GO:0048169)2.25866836
200activation of signaling protein activity involved in unfolded protein response (GO:0006987)2.25372505

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse5.80110715
2BP1_19119308_ChIP-ChIP_Hs578T_Human4.42976640
3TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat3.91877208
4PPARG_19300518_ChIP-PET_3T3-L1_Mouse3.76639235
5EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.54950037
6GATA1_22025678_ChIP-Seq_K562_Human3.31029256
7* SCL_19346495_ChIP-Seq_HPC-7_Human3.07765755
8* GATA1_19941827_ChIP-Seq_MEL_Mouse2.87998497
9* LYL1_20887958_ChIP-Seq_HPC-7_Mouse2.84899329
10TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse2.69282156
11* RUNX1_20887958_ChIP-Seq_HPC-7_Mouse2.67561139
12ESRRB_18555785_ChIP-Seq_MESCs_Mouse2.61629411
13TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse2.48785403
14IRF8_22096565_ChIP-ChIP_GC-B_Human2.46926799
15MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human2.39710686
16MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.37949062
17STAT6_20620947_ChIP-Seq_CD4_POS_T_Human2.32143115
18* GATA1_22383799_ChIP-Seq_G1ME_Mouse2.30833382
19EZH2_22144423_ChIP-Seq_EOC_Human2.26116283
20GATA1_19941826_ChIP-Seq_K562_Human2.24711712
21* LMO2_20887958_ChIP-Seq_HPC-7_Mouse2.22758831
22RNF2_18974828_ChIP-Seq_MESCs_Mouse2.22435018
23EZH2_18974828_ChIP-Seq_MESCs_Mouse2.22435018
24DROSHA_22980978_ChIP-Seq_HELA_Human2.05815263
25KLF1_20508144_ChIP-Seq_FETAL-LIVER-ERYTHROID_Mouse2.05074671
26TBX20_22080862_ChIP-Seq_HEART_Mouse2.03398853
27TBX20_22328084_ChIP-Seq_HEART_Mouse2.03398853
28TRIM28_21343339_ChIP-Seq_HEK293_Human2.02804594
29SRF_21415370_ChIP-Seq_HL-1_Mouse2.02054800
30NR4A2_19515692_ChIP-ChIP_MN9D_Mouse2.01994470
31SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.00194088
32* GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.99507205
33PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.97830253
34JARID2_20075857_ChIP-Seq_MESCs_Mouse1.97434191
35* FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.96713812
36RARB_27405468_Chip-Seq_BRAIN_Mouse1.95922361
37* TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.94702080
38DNAJC2_21179169_ChIP-ChIP_NT2_Human1.93060224
39SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.92117921
40* THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.91922396
41EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.91214252
42MYB_21317192_ChIP-Seq_ERMYB_Mouse1.91108122
43REST_18959480_ChIP-ChIP_MESCs_Mouse1.90960062
44MTF2_20144788_ChIP-Seq_MESCs_Mouse1.90123731
45SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.89364416
46TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.86434715
47ESR2_21235772_ChIP-Seq_MCF-7_Human1.85240316
48EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.79132253
49* SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.78080317
50SPI1_20517297_ChIP-Seq_HL60_Human1.76719146
51ZNF263_19887448_ChIP-Seq_K562_Human1.75898337
52VDR_21846776_ChIP-Seq_THP-1_Human1.75208765
53GATA4_21415370_ChIP-Seq_HL-1_Mouse1.75195445
54TET1_21490601_ChIP-Seq_MESCs_Mouse1.71113329
55CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.70463236
56JARID2_20064375_ChIP-Seq_MESCs_Mouse1.70148603
57GATA2_19941826_ChIP-Seq_K562_Human1.68966174
58KDM2B_26808549_Chip-Seq_K562_Human1.67850250
59* MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.66887177
60* TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.66740015
61RARG_19884340_ChIP-ChIP_MEFs_Mouse1.64540092
62CTCF_27219007_Chip-Seq_Bcells_Human1.63959693
63SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.63644303
64REST_21632747_ChIP-Seq_MESCs_Mouse1.63579955
65SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.62157296
66* CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.61265285
67SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.59947811
68* SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.59822329
69SUZ12_27294783_Chip-Seq_ESCs_Mouse1.59686818
70CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.56972078
71RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.55556599
72ZFP281_18757296_ChIP-ChIP_E14_Mouse1.53618116
73RNF2_27304074_Chip-Seq_ESCs_Mouse1.52195118
74* GATA2_22383799_ChIP-Seq_G1ME_Mouse1.52110972
75ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.51714287
76BCL6_27268052_Chip-Seq_Bcells_Human1.51083174
77ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.50492811
78NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.49916951
79PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.49913574
80EED_16625203_ChIP-ChIP_MESCs_Mouse1.49434344
81EP300_21415370_ChIP-Seq_HL-1_Mouse1.49401671
82EZH2_27304074_Chip-Seq_ESCs_Mouse1.49056982
83MEF2A_21415370_ChIP-Seq_HL-1_Mouse1.45074919
84ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.44914742
85BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.44839816
86SPI1_23127762_ChIP-Seq_K562_Human1.44326462
87SMC4_20622854_ChIP-Seq_HELA_Human1.43051423
88STAT4_19710469_ChIP-ChIP_TH1__Mouse1.42658365
89ERG_21242973_ChIP-ChIP_JURKAT_Human1.42483287
90NKX2-5_21415370_ChIP-Seq_HL-1_Mouse1.41673134
91EZH2_27294783_Chip-Seq_ESCs_Mouse1.40384766
92* TCF7_22412390_ChIP-Seq_EML_Mouse1.39509782
93RACK7_27058665_Chip-Seq_MCF-7_Human1.39065729
94BRD4_27068464_Chip-Seq_AML-cells_Mouse1.39049373
95GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.38251841
96UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.37860057
97SREBP1_19666523_ChIP-Seq_LIVER_Mouse1.36237540
98RUNX1_22412390_ChIP-Seq_EML_Mouse1.36165909
99MAF_26560356_Chip-Seq_TH1_Human1.34405687
100IRF8_27001747_Chip-Seq_BMDM_Mouse1.34280424
101NOTCH1_21737748_ChIP-Seq_TLL_Human1.33667204
102TET1_21451524_ChIP-Seq_MESCs_Mouse1.33599927
103GATA3_20176728_ChIP-ChIP_TSCs_Mouse1.33598258
104STAT3_19079543_ChIP-ChIP_MESCs_Mouse1.32715997
105TP53_20018659_ChIP-ChIP_R1E_Mouse1.31172807
106IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.30344446
107ELF1_20517297_ChIP-Seq_JURKAT_Human1.30073242
108* WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.29340726
109NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.28650830
110SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.27147059
111RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.26955584
112SPI1_23547873_ChIP-Seq_NB4_Human1.21770279
113MYC_22102868_ChIP-Seq_BL_Human1.21587294
114SMAD2/3_21741376_ChIP-Seq_ESCs_Human1.20746348
115* SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.20567245
116CTNNB1_20460455_ChIP-Seq_HCT116_Human1.19921993
117* EBNA2_21746931_ChIP-Seq_IB4-LCL_Human1.19029955
118TP53_22127205_ChIP-Seq_IMR90_Human1.18661103
119CREB1_26743006_Chip-Seq_LNCaP_Human1.18608435
120SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.18016950
121BCOR_27268052_Chip-Seq_Bcells_Human1.17975207
122RAD21_21589869_ChIP-Seq_MESCs_Mouse1.17360126
123SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.15552028
124* PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse1.15347268
125SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.15003291
126MYB_26560356_Chip-Seq_TH2_Human1.14247708
127TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.13419453
128VDR_24763502_ChIP-Seq_THP-1_Human1.13020468
129ERG_20887958_ChIP-Seq_HPC-7_Mouse1.12886543
130* GATA1_19941827_ChIP-Seq_MEL86_Mouse1.12821826
131ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.11569919
132STAT1_20625510_ChIP-Seq_HELA_Human1.11549852
133CTCF_21964334_ChIP-Seq_BJAB-B_Human1.11306256
134LXR_22292898_ChIP-Seq_THP-1_Human1.10090133
135ZFP281_27345836_Chip-Seq_ESCs_Mouse1.10048974
136CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.09786182
137TP63_22573176_ChIP-Seq_HFKS_Human1.09247511
138UTX_26944678_Chip-Seq_JUKART_Human1.09140538
139OLIG2_26023283_ChIP-Seq_AINV15_Mouse1.08744592
140* RBPJ_21746931_ChIP-Seq_IB4-LCL_Human1.08375605
141CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.08128625
142ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.07147444
143E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.07127494
144PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.06305291
145RUNX_20019798_ChIP-Seq_JUKART_Human1.06248531
146SRY_22984422_ChIP-ChIP_TESTIS_Rat1.05953857
147ESR1_21235772_ChIP-Seq_MCF-7_Human1.05452244
148DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.04341446
149CTCF_21964334_Chip-Seq_Bcells_Human1.04007367
150YY1_22570637_ChIP-Seq_MALME-3M_Human1.03967348
151ELK3_25401928_ChIP-Seq_HUVEC_Human1.03376516
152P68_20966046_ChIP-Seq_HELA_Human1.03169555
153IRF8_21731497_ChIP-ChIP_J774_Mouse1.02421808
154RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.01466165
155SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.00209941
156* TBX5_21415370_ChIP-Seq_HL-1_Mouse0.99918689
157TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.99260908
158CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse0.99134597
159IRF1_21803131_ChIP-Seq_MONOCYTES_Human0.98829240
160CTCF_26484167_Chip-Seq_Bcells_Mouse0.98748383
161TP53_23651856_ChIP-Seq_MEFs_Mouse0.97963201
162RXR_22158963_ChIP-Seq_LIVER_Mouse0.97561380
163PHC1_16625203_ChIP-ChIP_MESCs_Mouse0.96642613
164NR0B1_18358816_ChIP-ChIP_MESCs_Mouse0.96408666
165SA1_27219007_Chip-Seq_ERYTHROID_Human0.96356619
166HOXB4_20404135_ChIP-ChIP_EML_Mouse0.96103305
167JARID1B-DAIN_22020125_ChIP-Seq_ESCs_Mouse0.95522729
168JARID1A_20064375_ChIP-Seq_MESCs_Mouse0.94776385
169RNF2_16625203_ChIP-ChIP_MESCs_Mouse0.94129463
170PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse0.93375726
171PPARD_23208498_ChIP-Seq_MDA-MB-231_Human0.91563428
172P300_27058665_Chip-Seq_ZR-75-30cells_Human0.91554005
173HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse0.91545588
174ELF1_17652178_ChIP-ChIP_JURKAT_Human0.91350037
175OCT4_20526341_ChIP-Seq_ESCs_Human0.90222383
176* WT1_25993318_ChIP-Seq_PODOCYTE_Human0.89071909
177GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.88722973
178* KDM2B_26808549_Chip-Seq_SUP-B15_Human0.88632331
179RUNX2_24764292_ChIP-Seq_MC3T3_Mouse0.88005075
180MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human0.87998328
181SIN3A_21632747_ChIP-Seq_MESCs_Mouse0.87841889
182TFAP2A_17053090_ChIP-ChIP_MCF-7_Human0.87221989
183CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse0.86374624
184MYC_27129775_Chip-Seq_CORNEA_Mouse0.85576730
185RING1B_27294783_Chip-Seq_ESCs_Mouse0.85406373
186RARA_24833708_ChIP-Seq_LIVER_Mouse0.85116537
187FOXO1_23066095_ChIP-Seq_LIVER_Mouse0.84598224
188MITF_21258399_ChIP-Seq_MELANOMA_Human0.82576774

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003646_muscle_fatigue5.64374030
2MP0002837_dystrophic_cardiac_calcinosis5.19606234
3MP0000751_myopathy4.46622586
4MP0004147_increased_porphyrin_level4.35092137
5MP0004859_abnormal_synaptic_plasticity4.12311367
6MP0000749_muscle_degeneration4.08824809
7MP0004084_abnormal_cardiac_muscle4.04582956
8MP0004215_abnormal_myocardial_fiber3.83579032
9MP0003656_abnormal_erythrocyte_physiolo3.81121870
10MP0003705_abnormal_hypodermis_morpholog3.53621456
11MP0004036_abnormal_muscle_relaxation3.35202556
12MP0009780_abnormal_chondrocyte_physiolo3.28715932
13MP0000013_abnormal_adipose_tissue2.98330704
14MP0004270_analgesia2.97729785
15MP0004145_abnormal_muscle_electrophysio2.89055384
16MP0005330_cardiomyopathy2.84680862
17MP0005646_abnormal_pituitary_gland2.82408744
18MP0008775_abnormal_heart_ventricle2.79802216
19MP0003880_abnormal_central_pattern2.54275428
20MP0002106_abnormal_muscle_physiology2.51837207
21MP0004087_abnormal_muscle_fiber2.50649985
22MP0002736_abnormal_nociception_after2.43890319
23MP0003635_abnormal_synaptic_transmissio2.40356124
24MP0005423_abnormal_somatic_nervous2.35722099
25MP0002972_abnormal_cardiac_muscle2.30921808
26MP0002269_muscular_atrophy2.29220999
27MP0004130_abnormal_muscle_cell2.24195706
28MP0006036_abnormal_mitochondrial_physio2.23167499
29MP0000747_muscle_weakness2.22948076
30MP0004885_abnormal_endolymph2.22214819
31MP0005620_abnormal_muscle_contractility2.14765247
32MP0001968_abnormal_touch/_nociception2.13084889
33MP0000750_abnormal_muscle_regeneration2.06989279
34MP0000759_abnormal_skeletal_muscle2.04250961
35MP0005369_muscle_phenotype2.03438370
36MP0005360_urolithiasis2.03024088
37MP0003183_abnormal_peptide_metabolism2.02117474
38MP0004510_myositis1.99659148
39MP0005385_cardiovascular_system_phenoty1.97906611
40MP0001544_abnormal_cardiovascular_syste1.97906611
41MP0002734_abnormal_mechanical_nocicepti1.94279629
42MP0002063_abnormal_learning/memory/cond1.93429689
43MP0001486_abnormal_startle_reflex1.89726214
44MP0010630_abnormal_cardiac_muscle1.85249343
45MP0004484_altered_response_of1.81334910
46MP0002064_seizures1.81309945
47MP0003137_abnormal_impulse_conducting1.79214414
48MP0001661_extended_life_span1.77266783
49MP0003828_pulmonary_edema1.75752180
50MP0000003_abnormal_adipose_tissue1.73732817
51MP0000343_altered_response_to1.67167328
52MP0002735_abnormal_chemical_nociception1.65114760
53MP0008569_lethality_at_weaning1.63723477
54MP0002272_abnormal_nervous_system1.61509347
55MP0009745_abnormal_behavioral_response1.58227975
56MP0009046_muscle_twitch1.57685529
57MP0006138_congestive_heart_failure1.56539318
58MP0002572_abnormal_emotion/affect_behav1.53219641
59MP0005397_hematopoietic_system_phenotyp1.46509063
60MP0001545_abnormal_hematopoietic_system1.46509063
61MP0003122_maternal_imprinting1.46263845
62MP0000534_abnormal_ureter_morphology1.45604739
63MP0001270_distended_abdomen1.39176660
64MP0002332_abnormal_exercise_endurance1.38807043
65MP0003329_amyloid_beta_deposits1.38570479
66MP0004085_abnormal_heartbeat1.38136734
67MP0002184_abnormal_innervation1.38057405
68MP0003221_abnormal_cardiomyocyte_apopto1.35187978
69MP0008995_early_reproductive_senescence1.35095986
70MP0005670_abnormal_white_adipose1.29831070
71MP0001502_abnormal_circadian_rhythm1.27694707
72MP0002822_catalepsy1.25387427
73MP0005410_abnormal_fertilization1.23517628
74MP0006054_spinal_hemorrhage1.23397578
75MP0003279_aneurysm1.21784071
76MP0003123_paternal_imprinting1.18955013
77MP0001835_abnormal_antigen_presentation1.16948284
78MP0010030_abnormal_orbit_morphology1.15836921
79MP0004185_abnormal_adipocyte_glucose1.13516786
80MP0000681_abnormal_thyroid_gland1.12113210
81MP0005623_abnormal_meninges_morphology1.12058661
82MP0000955_abnormal_spinal_cord1.11844794
83MP0006276_abnormal_autonomic_nervous1.11794416
84MP0002066_abnormal_motor_capabilities/c1.11025209
85MP0003283_abnormal_digestive_organ1.09797793
86MP0002249_abnormal_larynx_morphology1.04678498
87MP0004233_abnormal_muscle_weight1.04674525
88MP0006035_abnormal_mitochondrial_morpho1.04581576
89MP0002396_abnormal_hematopoietic_system1.01580393
90MP0004808_abnormal_hematopoietic_stem0.99552126
91MP0002733_abnormal_thermal_nociception0.98496165
92MP0001853_heart_inflammation0.97925198
93MP0001440_abnormal_grooming_behavior0.97407376
94MP0003942_abnormal_urinary_system0.97207759
95MP0002877_abnormal_melanocyte_morpholog0.96874928
96MP0000678_abnormal_parathyroid_gland0.95989139
97MP0002067_abnormal_sensory_capabilities0.95593764
98MP0001984_abnormal_olfaction0.95471021
99MP0001970_abnormal_pain_threshold0.95029292
100MP0002882_abnormal_neuron_morphology0.94927984
101MP0005666_abnormal_adipose_tissue0.93400161
102MP0002938_white_spotting0.92708898
103MP0002229_neurodegeneration0.92408639
104MP0000566_synostosis0.92231252
105MP0002557_abnormal_social/conspecific_i0.91630474
106MP0003633_abnormal_nervous_system0.91620338
107MP0003634_abnormal_glial_cell0.91120779
108MP0005266_abnormal_metabolism0.90140547
109MP0002132_abnormal_respiratory_system0.89524254
110MP0000266_abnormal_heart_morphology0.89225816
111MP0002295_abnormal_pulmonary_circulatio0.88139842
112MP0000920_abnormal_myelination0.87638995
113MP0002127_abnormal_cardiovascular_syste0.87140290
114MP0000685_abnormal_immune_system0.86560836
115MP0009785_altered_susceptibility_to0.85213357
116MP0005367_renal/urinary_system_phenotyp0.84236334
117MP0000516_abnormal_urinary_system0.84236334
118MP0003567_abnormal_fetal_cardiomyocyte0.84159687
119MP0005464_abnormal_platelet_physiology0.83909926
120MP0000026_abnormal_inner_ear0.83148105
121MP0003724_increased_susceptibility_to0.81102019
122MP0000762_abnormal_tongue_morphology0.80618635
123MP0003631_nervous_system_phenotype0.80482297
124MP0002069_abnormal_eating/drinking_beha0.80432041
125MP0004811_abnormal_neuron_physiology0.79957115
126MP0001963_abnormal_hearing_physiology0.79504799
127MP0001299_abnormal_eye_distance/0.79485077
128MP0003806_abnormal_nucleotide_metabolis0.79285708
129MP0001849_ear_inflammation0.78960677
130MP0005671_abnormal_response_to0.78293945
131MP0005165_increased_susceptibility_to0.78225212
132MP0005332_abnormal_amino_acid0.77707078
133MP0005551_abnormal_eye_electrophysiolog0.76154646
134MP0005083_abnormal_biliary_tract0.75111592
135MP0002108_abnormal_muscle_morphology0.74944517
136MP0002896_abnormal_bone_mineralization0.74558669
137MP0002148_abnormal_hypersensitivity_rea0.74076211
138MP0001905_abnormal_dopamine_level0.73867987
139MP0002419_abnormal_innate_immunity0.71732770
140MP0000631_abnormal_neuroendocrine_gland0.71475903
141MP0001756_abnormal_urination0.71258660
142MP0003191_abnormal_cellular_cholesterol0.71203633
143MP0005025_abnormal_response_to0.69576057
144MP0000733_abnormal_muscle_development0.69131484
145MP0002398_abnormal_bone_marrow0.68572041
146MP0001501_abnormal_sleep_pattern0.68109356
147MP0000230_abnormal_systemic_arterial0.68075013
148MP0004043_abnormal_pH_regulation0.67685589
149MP0000778_abnormal_nervous_system0.67610569
150MP0004858_abnormal_nervous_system0.67294580
151MP0001348_abnormal_lacrimal_gland0.67153379
152MP0002089_abnormal_postnatal_growth/wei0.66912273
153MP0001944_abnormal_pancreas_morphology0.66865388
154MP0005319_abnormal_enzyme/_coenzyme0.64997694
155MP0001340_abnormal_eyelid_morphology0.64976502
156MP0002128_abnormal_blood_circulation0.64313887
157MP0005636_abnormal_mineral_homeostasis0.64193048
158MP0003436_decreased_susceptibility_to0.64056204
159MP0002909_abnormal_adrenal_gland0.63721589
160MP0003878_abnormal_ear_physiology0.62177064
161MP0005377_hearing/vestibular/ear_phenot0.62177064
162MP0001790_abnormal_immune_system0.61927316
163MP0005387_immune_system_phenotype0.61927316
164MP0003566_abnormal_cell_adhesion0.61397928
165MP0005000_abnormal_immune_tolerance0.60181808
166MP0005058_abnormal_lysosome_morphology0.59544743
167MP0000358_abnormal_cell_content/0.58385423
168MP0008469_abnormal_protein_level0.57461017
169MP0009278_abnormal_bone_marrow0.56672322
170MP0002078_abnormal_glucose_homeostasis0.56309825
171MP0002429_abnormal_blood_cell0.55525876
172MP0002722_abnormal_immune_system0.55325649
173MP0002723_abnormal_immune_serum0.53058898
174MP0003186_abnormal_redox_activity0.52394823
175MP0010368_abnormal_lymphatic_system0.51974662
176MP0002405_respiratory_system_inflammati0.51475655
177MP0005584_abnormal_enzyme/coenzyme_acti0.50213817
178MP0005503_abnormal_tendon_morphology0.49861111
179MP0000689_abnormal_spleen_morphology0.49752117
180MP0001879_abnormal_lymphatic_vessel0.49715427
181MP0001819_abnormal_immune_cell0.49637275
182MP0003763_abnormal_thymus_physiology0.48676454
183MP0002420_abnormal_adaptive_immunity0.48537765
184MP0002452_abnormal_antigen_presenting0.48344012
185MP0008438_abnormal_cutaneous_collagen0.47382823
186MP0003879_abnormal_hair_cell0.47072184

Predicted human phenotypes

RankGene SetZ-score
1Exercise-induced muscle cramps (HP:0003710)6.22696395
2Exercise-induced myalgia (HP:0003738)5.99818870
3Action tremor (HP:0002345)5.62147744
4Calf muscle hypertrophy (HP:0008981)5.49491415
5Muscle hypertrophy of the lower extremities (HP:0008968)5.32872456
6Sudden death (HP:0001699)5.27252610
7Abnormality of the heme biosynthetic pathway (HP:0010472)5.12337879
8Myoglobinuria (HP:0002913)5.11867702
9Ventricular tachycardia (HP:0004756)4.91253412
10Subaortic stenosis (HP:0001682)4.35770792
11Abnormality of the left ventricular outflow tract (HP:0011103)4.35770792
12Asymmetric septal hypertrophy (HP:0001670)4.28515837
13Muscle fiber splitting (HP:0003555)4.20371974
14Rhabdomyolysis (HP:0003201)4.10083749
15Lipoatrophy (HP:0100578)4.08654522
16Atrial fibrillation (HP:0005110)4.08044321
17Abnormality of the calf musculature (HP:0001430)4.07932329
18Myokymia (HP:0002411)3.91946662
19Supraventricular tachycardia (HP:0004755)3.79156082
20Primary atrial arrhythmia (HP:0001692)3.79017737
21Esophageal varix (HP:0002040)3.77989141
22Supraventricular arrhythmia (HP:0005115)3.69822562
23Hyporeflexia of lower limbs (HP:0002600)3.66487637
24Palpitations (HP:0001962)3.61525664
25Increased connective tissue (HP:0009025)3.53036245
26EMG: myopathic abnormalities (HP:0003458)3.50538817
27Ankle clonus (HP:0011448)3.49112146
28Myotonia (HP:0002486)3.49000264
29Dilated cardiomyopathy (HP:0001644)3.48793042
30Heterochromia iridis (HP:0001100)3.47348946
31Bundle branch block (HP:0011710)3.41788233
32Muscle fiber inclusion bodies (HP:0100299)3.30980566
33Constricted visual fields (HP:0001133)3.30583165
34Hepatic necrosis (HP:0002605)3.22040941
35White forelock (HP:0002211)3.20323916
36Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)3.18407234
37Abnormal mitochondria in muscle tissue (HP:0008316)3.15952769
38Abnormal umbilical cord blood vessels (HP:0011403)3.05622925
39Single umbilical artery (HP:0001195)3.05622925
40Abnormality of the fetal cardiovascular system (HP:0010948)3.05622925
41Muscle stiffness (HP:0003552)3.04160709
42Acute necrotizing encephalopathy (HP:0006965)2.99948438
43Type 1 muscle fiber predominance (HP:0003803)2.96268614
44Hepatocellular necrosis (HP:0001404)2.92776132
45Difficulty running (HP:0009046)2.90252446
46Syncope (HP:0001279)2.88432921
47Congenital sensorineural hearing impairment (HP:0008527)2.81389390
48Difficulty climbing stairs (HP:0003551)2.78525551
49Focal motor seizures (HP:0011153)2.78484144
50Heart block (HP:0012722)2.72213093
51Intention tremor (HP:0002080)2.68761602
52Mitochondrial inheritance (HP:0001427)2.68112116
53Patchy hypopigmentation of hair (HP:0011365)2.66937893
54Prolonged QT interval (HP:0001657)2.66754266
55Oligomenorrhea (HP:0000876)2.66195624
56Increased muscle lipid content (HP:0009058)2.65324514
57Biconcave vertebral bodies (HP:0004586)2.64608248
58Diaphragmatic weakness (HP:0009113)2.64445109
59Reticulocytosis (HP:0001923)2.64358543
60Abnormal atrioventricular conduction (HP:0005150)2.64205791
61Fatigue (HP:0012378)2.62778518
62Focal seizures (HP:0007359)2.61139796
63Abnormality of the lower motor neuron (HP:0002366)2.60976094
64Supranuclear gaze palsy (HP:0000605)2.60271467
65Esophageal neoplasm (HP:0100751)2.58102509
66Neoplasm of head and neck (HP:0012288)2.58102509
67Visceral angiomatosis (HP:0100761)2.57988489
68Impaired vibration sensation in the lower limbs (HP:0002166)2.57781766
69Nemaline bodies (HP:0003798)2.57520558
70Hypoalphalipoproteinemia (HP:0003233)2.55377870
71Decreased activity of mitochondrial respiratory chain (HP:0008972)2.54368789
72Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.54368789
73Distal upper limb amyotrophy (HP:0007149)2.52894352
74Upper limb amyotrophy (HP:0009129)2.52894352
75Areflexia of lower limbs (HP:0002522)2.50112120
76Increased intramyocellular lipid droplets (HP:0012240)2.49642780
77Increased CSF lactate (HP:0002490)2.49106519
78Hand muscle atrophy (HP:0009130)2.47458008
79Exercise intolerance (HP:0003546)2.46866474
80Cholelithiasis (HP:0001081)2.45877029
81Depression (HP:0000716)2.45402898
82Ventricular arrhythmia (HP:0004308)2.43002367
83Atonic seizures (HP:0010819)2.41029537
84Acute encephalopathy (HP:0006846)2.40862293
85Poikilocytosis (HP:0004447)2.40680471
86Right ventricular cardiomyopathy (HP:0011663)2.38671637
87Myocardial infarction (HP:0001658)2.36746075
88Ketoacidosis (HP:0001993)2.35150860
89Clonus (HP:0002169)2.31383440
90Lactic acidosis (HP:0003128)2.30540850
91Hypoglycemic coma (HP:0001325)2.29499405
92Progressive macrocephaly (HP:0004481)2.29213303
93Hemangiomatosis (HP:0007461)2.29136530
94Distal arthrogryposis (HP:0005684)2.28819444
95Abnormality of skeletal muscle fiber size (HP:0012084)2.28397087
96Spastic gait (HP:0002064)2.26888300
97Spontaneous hematomas (HP:0007420)2.26281588
98Ulnar deviation of the wrist (HP:0003049)2.25473554
99Increased variability in muscle fiber diameter (HP:0003557)2.24762468
100Cerebral hypomyelination (HP:0006808)2.24402955
101Abnormality of the umbilical cord (HP:0010881)2.24091572
102Truncal ataxia (HP:0002078)2.23196568
103Abnormal number of erythroid precursors (HP:0012131)2.22758008
104Atrioventricular block (HP:0001678)2.22707893
105Distal lower limb muscle weakness (HP:0009053)2.22485703
106Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.20174929
107Abnormality of alanine metabolism (HP:0010916)2.20174929
108Hyperalaninemia (HP:0003348)2.20174929
109Myopathic facies (HP:0002058)2.18620130
110Back pain (HP:0003418)2.17528407
111Polycythemia (HP:0001901)2.17309467
112Nausea (HP:0002018)2.17138028
113Abnormality of the tricuspid valve (HP:0001702)2.15341781
114Conjugated hyperbilirubinemia (HP:0002908)2.14959951
115Petechiae (HP:0000967)2.12161022
116Dysmetria (HP:0001310)2.10699182
117Thin ribs (HP:0000883)2.10505181
118Tinnitus (HP:0000360)2.10165973
119Neck muscle weakness (HP:0000467)2.09894772
120Abnormal gallbladder morphology (HP:0012437)2.09610522
121Insulin-resistant diabetes mellitus (HP:0000831)2.08573986
122Hypoplastic left heart (HP:0004383)2.08572480
123Maternal diabetes (HP:0009800)2.08032547
124Limb-girdle muscle atrophy (HP:0003797)2.07979734
125Abnormal EKG (HP:0003115)2.07717075
126Protrusio acetabuli (HP:0003179)2.07633744
127Left ventricular hypertrophy (HP:0001712)2.06781004
128Progressive muscle weakness (HP:0003323)2.05550553
129Respiratory failure (HP:0002878)2.05547103
130Abnormality of glycolysis (HP:0004366)2.05329227
131Ragged-red muscle fibers (HP:0003200)2.05207318
132Insomnia (HP:0100785)2.04471693
133Neuroendocrine neoplasm (HP:0100634)2.04016780
134Pheochromocytoma (HP:0002666)2.02833345
135Reduced subcutaneous adipose tissue (HP:0003758)2.01254824
136Epileptic encephalopathy (HP:0200134)2.00750975
137Generalized aminoaciduria (HP:0002909)2.00247665
138Hammertoe (HP:0001765)1.99659216
139Increased serum ferritin (HP:0003281)1.98935262
140Facial diplegia (HP:0001349)1.96076760
141Abnormality of dicarboxylic acid metabolism (HP:0010995)1.93124085
142Dicarboxylic aciduria (HP:0003215)1.93124085
143Large for gestational age (HP:0001520)1.92313393
144Poor speech (HP:0002465)1.92250908
145Generalized muscle weakness (HP:0003324)1.91150506
146Muscular dystrophy (HP:0003560)1.90877328
147Rimmed vacuoles (HP:0003805)1.90684013
148Cerebral edema (HP:0002181)1.90074229
149Prolonged bleeding time (HP:0003010)1.90027712
150Abnormality of the nasal mucosa (HP:0000433)1.89862900
151Increased serum pyruvate (HP:0003542)1.89459596
152Testicular atrophy (HP:0000029)1.87865088
153Tubulointerstitial nephritis (HP:0001970)1.87010074
154Akinesia (HP:0002304)1.84817339
155Febrile seizures (HP:0002373)1.83217855
156Obstructive sleep apnea (HP:0002870)1.82520668
157Ileus (HP:0002595)1.81033885
158Hypopigmentation of the fundus (HP:0007894)1.79260996
159Rapidly progressive (HP:0003678)1.78278924
160Urinary incontinence (HP:0000020)1.77512270
161Abnormality of carpal bone ossification (HP:0006257)1.74988483
162Postural tremor (HP:0002174)1.74909923
163Spinal canal stenosis (HP:0003416)1.74254835
164Mildly elevated creatine phosphokinase (HP:0008180)1.73091809
165Athetosis (HP:0002305)1.68529826
166Abnormality of the corticospinal tract (HP:0002492)1.68503336
167Lower limb muscle weakness (HP:0007340)1.68317680
168Urinary bladder sphincter dysfunction (HP:0002839)1.68069319
169Decreased number of large peripheral myelinated nerve fibers (HP:0003387)1.67954766
170Delusions (HP:0000746)1.66553964
171Venous abnormality (HP:0002624)1.66515699
172Hypoplastic heart (HP:0001961)1.66136093
173Premature rupture of membranes (HP:0001788)1.63697557
174Distal lower limb amyotrophy (HP:0008944)1.63380547
175Anxiety (HP:0000739)1.61087483
176Scanning speech (HP:0002168)1.61006191
177Lower limb amyotrophy (HP:0007210)1.60329611
178Neurofibrillary tangles (HP:0002185)1.58799283
179Hyperphosphatemia (HP:0002905)1.57898549
180Conjunctival telangiectasia (HP:0000524)1.56268613
181Growth hormone excess (HP:0000845)1.55106648
182Bowel incontinence (HP:0002607)1.54753196
183Decreased subcutaneous fat (HP:0001002)1.54124898
184Visual hallucinations (HP:0002367)1.53376930
185Homocystinuria (HP:0002156)1.52727362
186Abnormality of homocysteine metabolism (HP:0010919)1.52727362
187Urinary urgency (HP:0000012)1.52478801
188Progressive cerebellar ataxia (HP:0002073)1.51896312
189Cerebral aneurysm (HP:0004944)1.51643499
190Spinal rigidity (HP:0003306)1.51370238
191Absence seizures (HP:0002121)1.51017638

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TTN5.10030253
2OBSCN3.88119374
3PDK43.30892860
4PDK33.30892860
5PHKG23.08649758
6PHKG13.08649758
7NTRK32.90433706
8EPHA42.82121158
9NME22.63646088
10NTRK22.59225010
11MARK12.57676167
12MYLK2.46355400
13PAK62.35519693
14MUSK2.31756387
15TRIB32.15149368
16BCKDK2.13196378
17MAP2K32.07496187
18TIE12.03853194
19PKN22.03625329
20PINK11.94548930
21PDK21.90267409
22LMTK21.83999042
23UHMK11.82524922
24TGFBR21.76443691
25FLT31.76125494
26EPHA21.72837821
27KIT1.72256739
28ICK1.68994240
29EPHB21.68254953
30CDK91.66786970
31GRK71.59086114
32DAPK21.58223192
33SGK4941.56356159
34SGK2231.56356159
35NTRK11.55835826
36ZAK1.51146541
37RIPK11.47622525
38MAPKAPK31.44879310
39PRPF4B1.36099183
40MAP4K11.36091281
41NEK11.34066935
42CAMK2B1.31984657
43PIM21.30743222
44LATS21.25146398
45MAP3K91.23705902
46TAOK31.22401034
47TYK21.21402052
48DMPK1.21225480
49CDK51.17897761
50STK241.16949749
51TRPM71.14664246
52MAP3K111.14464021
53CAMKK11.14365388
54DAPK11.14245671
55SGK31.14073379
56JAK31.13885073
57NEK61.13732719
58SMG11.12840261
59TAOK21.09547874
60TBK11.08225849
61RPS6KB21.05969980
62CAMK2G1.05939988
63MINK11.05281060
64INSRR1.04636727
65MAP3K51.04624232
66ARAF1.04358144
67PIK3CA1.03862599
68MAPK121.03812851
69CCNB11.03509974
70EEF2K1.01641345
71TEC1.01600821
72PAK40.98933338
73KSR20.98820987
74TYRO30.98270806
75TXK0.96623753
76SGK20.95830350
77DYRK1B0.95577565
78MAP3K70.94403136
79STK380.93187972
80EIF2AK10.92827032
81PTK20.91062622
82BRSK10.90776794
83MARK20.89147987
84STK40.88795363
85PDGFRA0.87889066
86MST1R0.87636240
87CAMKK20.87221679
88KDR0.86024866
89SIK30.83552843
90JAK10.82511841
91TGFBR10.82363372
92MAP2K10.81807822
93FGR0.81406508
94LIMK10.80472085
95NEK90.79752645
96MAPK110.79462238
97MTOR0.76747408
98CDK190.74560964
99ERN10.73087786
100GRK50.72946853
101MAP2K60.72542120
102PRKCG0.72538627
103ZAP700.71922652
104PTK60.71381795
105MAPKAPK50.70864192
106RPS6KB10.69753433
107PDPK10.67974392
108SYK0.67806495
109JAK20.67494392
110DYRK20.65698875
111CASK0.65652862
112BTK0.65468240
113CAMK2A0.63693180
114AKT20.63609427
115NME10.61699271
116CDC42BPA0.61445996
117PRKAA20.60656793
118CDK80.59972715
119PIK3CG0.59844657
120CAMK10.59471819
121MET0.58086385
122IRAK30.58067266
123MAP3K30.57388419
124CDK150.55500617
125SIK20.54394436
126MARK30.53931138
127CDK11A0.53869995
128DYRK30.53547110
129ILK0.53171934
130CDK180.52628833
131CAMK40.51870570
132PTK2B0.51722617
133MATK0.51420565
134CAMK2D0.50953381
135MAP2K70.50760763
136PRKAA10.50250393
137IRAK20.49208185
138SIK10.49095257
139RPS6KC10.49010747
140RPS6KL10.49010747
141RPS6KA60.48563840
142ROCK20.47037745
143TESK10.46832012
144MAP3K10.45718036
145CDK140.45133142
146CSNK1A10.44662455
147VRK10.42975806
148PIM10.42347988
149MAP2K40.41114872
150MAPK100.40804326
151SCYL20.40091535
152DAPK30.39959133
153PLK20.39191125
154PAK20.38775346
155RPS6KA40.37931934
156IKBKB0.37515097
157ROCK10.37215309
158PRKCI0.36663007
159SGK10.36630955
160PDK10.35749465
161PRKG20.34396057
162MAPKAPK20.33957189
163IKBKE0.33729523
164EPHB10.33260297
165PRKD10.31916895
166BRSK20.29746818
167IRAK40.29727328
168PRKACG0.28384797
169WNK10.27746631
170PRKD30.27536972
171TAOK10.26975940
172WEE10.26105978

Predicted pathways (KEGG)

RankGene SetZ-score
1Citrate cycle (TCA cycle)_Homo sapiens_hsa000205.65356564
2Cardiac muscle contraction_Homo sapiens_hsa042603.78476243
3Parkinsons disease_Homo sapiens_hsa050123.48990050
4Oxidative phosphorylation_Homo sapiens_hsa001903.27463509
5Synaptic vesicle cycle_Homo sapiens_hsa047213.10685881
6Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054103.08402820
7Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008603.07532321
82-Oxocarboxylic acid metabolism_Homo sapiens_hsa012103.06739288
9Dilated cardiomyopathy_Homo sapiens_hsa054142.79599793
10Nicotine addiction_Homo sapiens_hsa050332.66120716
11Arginine biosynthesis_Homo sapiens_hsa002202.65653023
12Propanoate metabolism_Homo sapiens_hsa006402.59169735
13Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049322.52453809
14Alzheimers disease_Homo sapiens_hsa050102.47390386
15GABAergic synapse_Homo sapiens_hsa047272.36965505
16Huntingtons disease_Homo sapiens_hsa050162.29301682
17Vibrio cholerae infection_Homo sapiens_hsa051102.12576292
18Carbon metabolism_Homo sapiens_hsa012002.11229120
19Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.09325942
20Fatty acid degradation_Homo sapiens_hsa000712.08478786
21Collecting duct acid secretion_Homo sapiens_hsa049662.08409526
22Morphine addiction_Homo sapiens_hsa050321.99567120
23Circadian entrainment_Homo sapiens_hsa047131.97615480
24Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.84757230
25Glutamatergic synapse_Homo sapiens_hsa047241.84523124
26Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.80490101
27Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.77241800
28Pyruvate metabolism_Homo sapiens_hsa006201.76518561
29Dopaminergic synapse_Homo sapiens_hsa047281.72149275
30Sulfur relay system_Homo sapiens_hsa041221.64632867
31Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.63603594
32Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.63536661
33Starch and sucrose metabolism_Homo sapiens_hsa005001.51594013
34Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.51182330
35Long-term potentiation_Homo sapiens_hsa047201.46772805
36Viral myocarditis_Homo sapiens_hsa054161.33520523
37Fatty acid metabolism_Homo sapiens_hsa012121.33423792
38Cholinergic synapse_Homo sapiens_hsa047251.33240571
39Galactose metabolism_Homo sapiens_hsa000521.32814324
40Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.31163408
41Amphetamine addiction_Homo sapiens_hsa050311.29134955
42Cocaine addiction_Homo sapiens_hsa050301.29121423
43Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.28709240
44DNA replication_Homo sapiens_hsa030301.28413949
45Other types of O-glycan biosynthesis_Homo sapiens_hsa005141.22840497
46Adipocytokine signaling pathway_Homo sapiens_hsa049201.22578698
47Aldosterone synthesis and secretion_Homo sapiens_hsa049251.17938390
48Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.15092728
49Insulin resistance_Homo sapiens_hsa049311.13508396
50Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.11788756
51Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.10876909
52Leishmaniasis_Homo sapiens_hsa051401.09671464
53Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.09242119
54Glucagon signaling pathway_Homo sapiens_hsa049221.09182788
55Legionellosis_Homo sapiens_hsa051341.00493271
56Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.96926828
57Hematopoietic cell lineage_Homo sapiens_hsa046400.95738146
58GnRH signaling pathway_Homo sapiens_hsa049120.95665772
59Osteoclast differentiation_Homo sapiens_hsa043800.93993017
60Phenylalanine metabolism_Homo sapiens_hsa003600.93952441
61Insulin signaling pathway_Homo sapiens_hsa049100.93788348
62Salivary secretion_Homo sapiens_hsa049700.93626705
63Cyanoamino acid metabolism_Homo sapiens_hsa004600.91795636
64Gastric acid secretion_Homo sapiens_hsa049710.90845813
65Serotonergic synapse_Homo sapiens_hsa047260.90717117
66Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.90666331
67Prion diseases_Homo sapiens_hsa050200.90493675
68Circadian rhythm_Homo sapiens_hsa047100.89164722
69Long-term depression_Homo sapiens_hsa047300.88050285
70Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.87789410
71Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.87757504
72Pentose phosphate pathway_Homo sapiens_hsa000300.86468599
73Fructose and mannose metabolism_Homo sapiens_hsa000510.84010082
74Toxoplasmosis_Homo sapiens_hsa051450.82736639
75Folate biosynthesis_Homo sapiens_hsa007900.79553025
76Taste transduction_Homo sapiens_hsa047420.79283809
77Glioma_Homo sapiens_hsa052140.78474536
78Phosphatidylinositol signaling system_Homo sapiens_hsa040700.78197557
79Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.76552131
80Measles_Homo sapiens_hsa051620.76025619
81Glycosaminoglycan degradation_Homo sapiens_hsa005310.75319289
82HIF-1 signaling pathway_Homo sapiens_hsa040660.75101512
83Fatty acid biosynthesis_Homo sapiens_hsa000610.74709106
84Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.74165021
85Calcium signaling pathway_Homo sapiens_hsa040200.72163661
86Estrogen signaling pathway_Homo sapiens_hsa049150.71577935
87cGMP-PKG signaling pathway_Homo sapiens_hsa040220.71356197
88Maturity onset diabetes of the young_Homo sapiens_hsa049500.71229532
89Platelet activation_Homo sapiens_hsa046110.70247089
90Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.69999962
91Regulation of autophagy_Homo sapiens_hsa041400.69847626
92Thyroid hormone signaling pathway_Homo sapiens_hsa049190.68323780
93Axon guidance_Homo sapiens_hsa043600.67963122
94Biosynthesis of amino acids_Homo sapiens_hsa012300.67830916
95cAMP signaling pathway_Homo sapiens_hsa040240.67775439
96Toll-like receptor signaling pathway_Homo sapiens_hsa046200.67295548
97Gap junction_Homo sapiens_hsa045400.66028334
98Bile secretion_Homo sapiens_hsa049760.65217559
99Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.64469789
100ErbB signaling pathway_Homo sapiens_hsa040120.64290159
101Vitamin B6 metabolism_Homo sapiens_hsa007500.61050609
102Tuberculosis_Homo sapiens_hsa051520.59667329
103Glycerophospholipid metabolism_Homo sapiens_hsa005640.59075223
104Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.58954551
105Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.58512384
106One carbon pool by folate_Homo sapiens_hsa006700.58153367
107Choline metabolism in cancer_Homo sapiens_hsa052310.57978577
108Central carbon metabolism in cancer_Homo sapiens_hsa052300.57049921
109Type II diabetes mellitus_Homo sapiens_hsa049300.56278038
110Melanogenesis_Homo sapiens_hsa049160.56108895
111Antigen processing and presentation_Homo sapiens_hsa046120.55966961
112Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.52998993
113Phospholipase D signaling pathway_Homo sapiens_hsa040720.52879313
114AMPK signaling pathway_Homo sapiens_hsa041520.52841833
115Other glycan degradation_Homo sapiens_hsa005110.52470534
116Olfactory transduction_Homo sapiens_hsa047400.51956894
117Thyroid hormone synthesis_Homo sapiens_hsa049180.51791558
118Jak-STAT signaling pathway_Homo sapiens_hsa046300.49421866
119ECM-receptor interaction_Homo sapiens_hsa045120.47467672
120ABC transporters_Homo sapiens_hsa020100.47428705
121VEGF signaling pathway_Homo sapiens_hsa043700.47187186
122Ribosome_Homo sapiens_hsa030100.46155573
123Influenza A_Homo sapiens_hsa051640.46120079
124PPAR signaling pathway_Homo sapiens_hsa033200.45950492
125Acute myeloid leukemia_Homo sapiens_hsa052210.45823289
126Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.45456092
127Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.44712890
128SNARE interactions in vesicular transport_Homo sapiens_hsa041300.44377357
129Apoptosis_Homo sapiens_hsa042100.44073613
130Herpes simplex infection_Homo sapiens_hsa051680.43817496
131Primary immunodeficiency_Homo sapiens_hsa053400.42962870
132mTOR signaling pathway_Homo sapiens_hsa041500.42593029
133Purine metabolism_Homo sapiens_hsa002300.42441172
134Arginine and proline metabolism_Homo sapiens_hsa003300.41794974
135Inositol phosphate metabolism_Homo sapiens_hsa005620.40379290
136Metabolic pathways_Homo sapiens_hsa011000.39824525
137Ras signaling pathway_Homo sapiens_hsa040140.39123306
138Sphingolipid signaling pathway_Homo sapiens_hsa040710.38719531
139Tyrosine metabolism_Homo sapiens_hsa003500.37448264
140Neurotrophin signaling pathway_Homo sapiens_hsa047220.36862123
141Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.36725698
142Pertussis_Homo sapiens_hsa051330.35736371
143Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.35693951
144Malaria_Homo sapiens_hsa051440.35548320
145Oxytocin signaling pathway_Homo sapiens_hsa049210.35413875
146Pyrimidine metabolism_Homo sapiens_hsa002400.35235917
147Vascular smooth muscle contraction_Homo sapiens_hsa042700.32455153
148Base excision repair_Homo sapiens_hsa034100.31315108
149beta-Alanine metabolism_Homo sapiens_hsa004100.30891084
150NF-kappa B signaling pathway_Homo sapiens_hsa040640.30550803
151RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.28383922
152Focal adhesion_Homo sapiens_hsa045100.28114760
153Carbohydrate digestion and absorption_Homo sapiens_hsa049730.27148512
154AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.26999706
155alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.24822216
156Cysteine and methionine metabolism_Homo sapiens_hsa002700.24804798
157Hepatitis B_Homo sapiens_hsa051610.24442019
158Lysosome_Homo sapiens_hsa041420.23710152
159Salmonella infection_Homo sapiens_hsa051320.23483787
160Amoebiasis_Homo sapiens_hsa051460.23015378
161Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.21813798
162Renin secretion_Homo sapiens_hsa049240.21769600
163Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.19435688
164Asthma_Homo sapiens_hsa053100.19398110
165Phagosome_Homo sapiens_hsa041450.19223550
166Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.18926256
167Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.18872053
168Insulin secretion_Homo sapiens_hsa049110.18835898
169Longevity regulating pathway - mammal_Homo sapiens_hsa042110.18813276

Most similar genes based on co-expression Upload to Enrichr

Tissue Expression Export image »

Cell Line Expression Export image »