SLC43A2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the L-amino acid transporter-3 or SLC43 family of transporters. The encoded protein mediates sodium-, chloride-, and pH-independent transport of L-isomers of neutral amino acids, including leucine, phenylalanine, valine and methionine. This protein may contribute to the transfer of amino acids across the placental membrane to the fetus. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1negative regulation of interleukin-12 production (GO:0032695)5.33820747
2positive regulation by symbiont of host defense response (GO:0052509)4.69431146
3modulation by symbiont of host defense response (GO:0052031)4.69431146
4modulation by organism of immune response of other organism involved in symbiotic interaction (GO:004.69431146
5modulation by organism of defense response of other organism involved in symbiotic interaction (GO:04.69431146
6positive regulation by organism of defense response of other organism involved in symbiotic interact4.69431146
7modulation by symbiont of host immune response (GO:0052553)4.69431146
8adhesion of symbiont to host cell (GO:0044650)3.98568922
9virion attachment to host cell (GO:0019062)3.98568922
10regulation of interferon-beta biosynthetic process (GO:0045357)3.96334347
11lipopolysaccharide-mediated signaling pathway (GO:0031663)3.91831550
12positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)3.83554161
13immunoglobulin mediated immune response (GO:0016064)3.80544973
14detection of molecule of bacterial origin (GO:0032490)3.80436147
15angiotensin maturation (GO:0002003)3.79012761
16detection of other organism (GO:0098543)3.73738857
17cellular extravasation (GO:0045123)3.73110358
18macrophage activation involved in immune response (GO:0002281)3.60382627
19T-helper 1 type immune response (GO:0042088)3.60061540
20germinal center formation (GO:0002467)3.54990851
21regulation of gamma-delta T cell activation (GO:0046643)3.47407951
22detection of bacterium (GO:0016045)3.45661458
23regulation of dendritic cell antigen processing and presentation (GO:0002604)3.42059102
24detection of external biotic stimulus (GO:0098581)3.40487527
25defense response to protozoan (GO:0042832)3.36016912
26antigen processing and presentation of endogenous peptide antigen (GO:0002483)3.34887439
27lipoprotein transport (GO:0042953)3.31806132
28antigen processing and presentation of endogenous antigen (GO:0019883)3.27726319
29response to muramyl dipeptide (GO:0032495)3.26761860
30neutrophil activation involved in immune response (GO:0002283)3.23774115
31response to protozoan (GO:0001562)3.23686938
32NIK/NF-kappaB signaling (GO:0038061)3.23537245
33regulation of tumor necrosis factor biosynthetic process (GO:0042534)3.22083954
34interferon-gamma-mediated signaling pathway (GO:0060333)3.21139995
35regulation of mast cell activation involved in immune response (GO:0033006)3.18921213
36adhesion of symbiont to host (GO:0044406)3.18658266
37regulation of mast cell activation (GO:0033003)3.17820825
38response to lipoprotein particle (GO:0055094)3.14375307
39negative regulation of cytokine production involved in immune response (GO:0002719)3.14079496
40regulation of vitamin D biosynthetic process (GO:0060556)3.13063224
41positive regulation of p38MAPK cascade (GO:1900745)3.12064470
42leukocyte aggregation (GO:0070486)3.10840950
43macroautophagy (GO:0016236)3.09685828
44regulation of antigen processing and presentation (GO:0002577)3.09417867
45detection of biotic stimulus (GO:0009595)3.08176397
46positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)3.08158694
47regulation of T-helper 2 cell differentiation (GO:0045628)3.07856789
48type I interferon signaling pathway (GO:0060337)3.06456897
49cellular response to type I interferon (GO:0071357)3.06456897
50antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)3.05962404
51response to type I interferon (GO:0034340)3.05144256
52positive regulation of type 2 immune response (GO:0002830)3.04640398
53negative regulation of cell killing (GO:0031342)3.04293360
54negative regulation of leukocyte mediated cytotoxicity (GO:0001911)3.04293360
55positive regulation of mast cell degranulation (GO:0043306)3.02573070
56positive regulation of mast cell activation involved in immune response (GO:0033008)3.02573070
57response to host immune response (GO:0052572)3.02144136
58response to immune response of other organism involved in symbiotic interaction (GO:0052564)3.02144136
59positive regulation of interleukin-2 biosynthetic process (GO:0045086)3.00750535
60regulation of T cell tolerance induction (GO:0002664)3.00517316
61regulation of myeloid leukocyte mediated immunity (GO:0002886)2.96184323
62positive regulation of NF-kappaB import into nucleus (GO:0042346)2.95206379
63negative regulation of lymphocyte mediated immunity (GO:0002707)2.93344971
64regulation of interleukin-12 production (GO:0032655)2.91699140
65production of molecular mediator involved in inflammatory response (GO:0002532)2.91294217
66intestinal absorption (GO:0050892)2.90330002
67negative regulation of T cell mediated immunity (GO:0002710)2.89767582
68regulation of tolerance induction (GO:0002643)2.89483172
69negative regulation of erythrocyte differentiation (GO:0045647)2.87134510
70positive regulation of chemokine biosynthetic process (GO:0045080)2.86544828
71regulation of mononuclear cell migration (GO:0071675)2.84982762
72intestinal cholesterol absorption (GO:0030299)2.82269494
73hydrogen peroxide biosynthetic process (GO:0050665)2.81621137
74neutrophil chemotaxis (GO:0030593)2.81073300
75myeloid dendritic cell differentiation (GO:0043011)2.78467617
76positive regulation of heat generation (GO:0031652)2.78088653
77mannose metabolic process (GO:0006013)2.77952390
78positive regulation of toll-like receptor signaling pathway (GO:0034123)2.77703056
79regulation of podosome assembly (GO:0071801)2.77286642
80microglial cell activation (GO:0001774)2.74986542
81negative regulation of leukocyte mediated immunity (GO:0002704)2.74701812
82neutrophil migration (GO:1990266)2.73988879
83response to host (GO:0075136)2.73735109
84response to host defenses (GO:0052200)2.73735109
85response to defenses of other organism involved in symbiotic interaction (GO:0052173)2.73735109
86antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G2.73725944
87myeloid leukocyte activation (GO:0002274)2.73558871
88regulation of T-helper 1 cell differentiation (GO:0045625)2.71804727
89B cell mediated immunity (GO:0019724)2.71753534
90cellular potassium ion homeostasis (GO:0030007)2.70780446
91protein localization to endosome (GO:0036010)2.64675157
92positive regulation of interleukin-8 biosynthetic process (GO:0045416)2.63866747
93regulation of ARF protein signal transduction (GO:0032012)2.63393691
94protein kinase C signaling (GO:0070528)2.63033105
95regulation of nitric-oxide synthase biosynthetic process (GO:0051769)2.62529743
96negative regulation of myeloid cell apoptotic process (GO:0033033)2.61722940
97peptide hormone processing (GO:0016486)2.58390003
98regulation of B cell receptor signaling pathway (GO:0050855)2.55547626
99L-amino acid import (GO:0043092)2.53613229
100sodium ion export (GO:0071436)2.53162328
101regulation of beta-amyloid formation (GO:1902003)2.49875727
102positive regulation of gamma-delta T cell activation (GO:0046645)2.47021574
103macrophage activation (GO:0042116)2.44804556
104positive regulation of membrane protein ectodomain proteolysis (GO:0051044)2.43979846
105myeloid cell activation involved in immune response (GO:0002275)2.42089370
106negative regulation of amyloid precursor protein catabolic process (GO:1902992)2.41401738
107neutrophil mediated immunity (GO:0002446)2.38383943
108potassium ion import (GO:0010107)2.38162398
109positive regulation of cellular amide metabolic process (GO:0034250)2.36965623
110regulation of leukocyte degranulation (GO:0043300)2.36076731
111cytidine deamination (GO:0009972)2.35499114
112cytidine metabolic process (GO:0046087)2.35499114
113cytidine catabolic process (GO:0006216)2.35499114
114apoptotic cell clearance (GO:0043277)2.34080428
115positive regulation of antigen processing and presentation (GO:0002579)2.33117101
116respiratory burst (GO:0045730)2.31719809
117I-kappaB phosphorylation (GO:0007252)2.30583149
118regulation of systemic arterial blood pressure by renin-angiotensin (GO:0003081)2.28792523
119retrograde transport, vesicle recycling within Golgi (GO:0000301)2.28095010
120glycosylceramide metabolic process (GO:0006677)2.27852701
121neutrophil activation (GO:0042119)2.27732112
122regulation of p38MAPK cascade (GO:1900744)2.27275229
123regulation of regulated secretory pathway (GO:1903305)2.26775480
124regulation of cellular amide metabolic process (GO:0034248)2.25696570
125leukocyte migration involved in inflammatory response (GO:0002523)2.25259168
126negative regulation of toll-like receptor 4 signaling pathway (GO:0034144)2.23671160
127granulocyte activation (GO:0036230)2.20417302
128positive regulation of interferon-alpha production (GO:0032727)2.18434620
129positive regulation of leukocyte degranulation (GO:0043302)2.17206081
130establishment of protein localization to Golgi (GO:0072600)2.16122832
131protein targeting to Golgi (GO:0000042)2.15741315
132regulation of ARF GTPase activity (GO:0032312)2.14504827
133negative regulation of bone resorption (GO:0045779)2.14276305
134negative regulation of platelet-derived growth factor receptor signaling pathway (GO:0010642)2.13414426
135pyrimidine ribonucleoside catabolic process (GO:0046133)2.13226446
136nerve growth factor signaling pathway (GO:0038180)2.12267759
137regulation of amyloid precursor protein catabolic process (GO:1902991)2.10402086
138phagosome maturation (GO:0090382)2.09484160
139regulation of interferon-alpha production (GO:0032647)2.09213747
140regulation of cholesterol storage (GO:0010885)2.08895301
141regulation of mast cell degranulation (GO:0043304)2.07948996
142negative regulation of interleukin-1 beta production (GO:0032691)2.06210666
143peptide catabolic process (GO:0043171)2.05928381
144B cell receptor signaling pathway (GO:0050853)2.05845016
145cytoskeletal anchoring at plasma membrane (GO:0007016)2.05676538
146negative regulation of antigen receptor-mediated signaling pathway (GO:0050858)2.05606128
147phospholipid translocation (GO:0045332)2.05103814
148lipid translocation (GO:0034204)2.05103814
149amino acid import (GO:0043090)2.04745361
150viral entry into host cell (GO:0046718)2.04668227
151relaxation of cardiac muscle (GO:0055119)2.04064262
152response to peptidoglycan (GO:0032494)2.03892589
153positive regulation of mast cell activation (GO:0033005)2.02967591
154regulation of antigen processing and presentation of peptide antigen (GO:0002583)2.02188107
155response to hepatocyte growth factor (GO:0035728)2.01632424
156cellular response to hepatocyte growth factor stimulus (GO:0035729)2.01632424
157negative regulation of interleukin-1 production (GO:0032692)2.00687730
158regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway (GO:19022352.00357573
159Golgi to endosome transport (GO:0006895)1.99610785
160actin filament polymerization (GO:0030041)1.98891269
161negative regulation of interleukin-6 production (GO:0032715)1.98573688
162cortical actin cytoskeleton organization (GO:0030866)1.98463337

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1IRF8_21731497_ChIP-ChIP_J774_Mouse2.89788984
2* SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse2.79528768
3* Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse2.72444084
4IRF8_27001747_Chip-Seq_BMDM_Mouse2.70530856
5IRF8_22096565_ChIP-ChIP_GC-B_Human2.47790504
6VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human2.45255230
7IRF8_22096565_ChIP-ChIP_GC-B_Mouse2.41507284
8BP1_19119308_ChIP-ChIP_Hs578T_Human2.23061256
9* NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse2.13047655
10STAT4_19710469_ChIP-ChIP_TH1__Mouse2.11693115
11SPI1_23547873_ChIP-Seq_NB4_Human2.08038034
12STAT6_20620947_ChIP-Seq_CD4_POS_T_Human2.01653007
13SPI1_22096565_ChIP-ChIP_GC-B_Mouse2.00126558
14* SPI1_23127762_ChIP-Seq_K562_Human1.95357851
15DROSHA_22980978_ChIP-Seq_HELA_Human1.91231066
16CDX2_19796622_ChIP-Seq_MESCs_Mouse1.78800301
17MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.76216955
18MAF_26560356_Chip-Seq_TH1_Human1.73122390
19TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.65188756
20GATA1_22025678_ChIP-Seq_K562_Human1.65101064
21* CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.64325066
22GATA2_21666600_ChIP-Seq_HMVEC_Human1.62532942
23LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.55766113
24SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.52203166
25VDR_24787735_ChIP-Seq_THP-1_Human1.48204745
26NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.46357724
27UTX_26944678_Chip-Seq_JUKART_Human1.46306828
28EGR1_19374776_ChIP-ChIP_THP-1_Human1.45142643
29MYB_26560356_Chip-Seq_TH2_Human1.43684264
30GATA1_19941826_ChIP-Seq_K562_Human1.41586672
31GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.39975184
32STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.36847533
33MYC_22102868_ChIP-Seq_BL_Human1.35674048
34RUNX_20019798_ChIP-Seq_JUKART_Human1.35148309
35MYB_21317192_ChIP-Seq_ERMYB_Mouse1.35118588
36SCL_19346495_ChIP-Seq_HPC-7_Human1.34664790
37E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.33631655
38THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.32023051
39ZNF217_24962896_ChIP-Seq_MCF-7_Human1.31932973
40KDM2B_26808549_Chip-Seq_SUP-B15_Human1.30332099
41PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.29947949
42CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse1.29394947
43NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.28516659
44ELK3_25401928_ChIP-Seq_HUVEC_Human1.28427691
45TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.27695744
46GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.27095185
47BRD4_27068464_Chip-Seq_AML-cells_Mouse1.26832117
48MAF_26560356_Chip-Seq_TH2_Human1.26808061
49VDR_24763502_ChIP-Seq_THP-1_Human1.26109000
50CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse1.25346779
51SMAD_19615063_ChIP-ChIP_OVARY_Human1.25181372
52FOXO3_23340844_ChIP-Seq_DLD1_Human1.24186976
53PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse1.23838145
54SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.23156133
55BCL6_27268052_Chip-Seq_Bcells_Human1.22394150
56PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.21424317
57ESR2_21235772_ChIP-Seq_MCF-7_Human1.21335501
58GATA2_19941826_ChIP-Seq_K562_Human1.20419547
59STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.20224824
60PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.20118212
61MYB_26560356_Chip-Seq_TH1_Human1.18951775
62SOX2_27498859_Chip-Seq_STOMACH_Mouse1.18070075
63IKZF1_21737484_ChIP-ChIP_HCT116_Human1.17560887
64BCOR_27268052_Chip-Seq_Bcells_Human1.16608432
65ESR1_21235772_ChIP-Seq_MCF-7_Human1.16130274
66EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.16028078
67NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.15063607
68AHR_22903824_ChIP-Seq_MCF-7_Human1.14772329
69FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.14365852
70BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.14022238
71ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.12821088
72GATA1_19941827_ChIP-Seq_MEL_Mouse1.10761209
73SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.10438836
74WT1_25993318_ChIP-Seq_PODOCYTE_Human1.10102914
75KDM2B_26808549_Chip-Seq_K562_Human1.10064469
76FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.09853197
77VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human1.09744791
78* KDM2B_26808549_Chip-Seq_DND41_Human1.09618127
79* CDX2_20551321_ChIP-Seq_CACO-2_Human1.09224452
80FOXA2_19822575_ChIP-Seq_HepG2_Human1.07470168
81ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.07020592
82FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.06915639
83GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.06637250
84LXR_22292898_ChIP-Seq_THP-1_Human1.04905716
85GATA2_22383799_ChIP-Seq_G1ME_Mouse1.04198610
86RARB_27405468_Chip-Seq_BRAIN_Mouse1.04137296
87TCF7_22412390_ChIP-Seq_EML_Mouse1.03584257
88MTF2_20144788_ChIP-Seq_MESCs_Mouse1.03541302
89* FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.03473395
90* PU_27001747_Chip-Seq_BMDM_Mouse1.01495287
91FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.01193703
92GATA3_26560356_Chip-Seq_TH2_Human1.00384731
93RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human0.99614303
94VDR_21846776_ChIP-Seq_THP-1_Human0.99373415
95ARNT_22903824_ChIP-Seq_MCF-7_Human0.98936573
96IRF1_21803131_ChIP-Seq_MONOCYTES_Human0.98740447
97STAT6_21828071_ChIP-Seq_BEAS2B_Human0.98705485
98PU.1_20513432_ChIP-Seq_Bcells_Mouse0.97741863
99RUNX1_22412390_ChIP-Seq_EML_Mouse0.95860139
100STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse0.95396130
101CTNNB1_20460455_ChIP-Seq_HCT116_Human0.94242545
102* GATA1_22383799_ChIP-Seq_G1ME_Mouse0.92073133
103PPAR_26484153_Chip-Seq_NCI-H1993_Human0.90824595
104GATA3_27048872_Chip-Seq_THYMUS_Human0.90506698
105* KDM2B_26808549_Chip-Seq_HPB-ALL_Human0.89851649
106MEIS1_20887958_ChIP-Seq_HPC-7_Mouse0.87789803
107RXR_22108803_ChIP-Seq_LS180_Human0.87634723
108SOX9_24532713_ChIP-Seq_HFSC_Mouse0.87478639
109LXR_22158963_ChIP-Seq_LIVER_Mouse0.87334855
110SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse0.85728900
111NR3C1_23031785_ChIP-Seq_PC12_Mouse0.85600532
112MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human0.85599360
113CTCF_27219007_Chip-Seq_ERYTHROID_Human0.85141058
114ELF1_20517297_ChIP-Seq_JURKAT_Human0.84990556
115REST_21632747_ChIP-Seq_MESCs_Mouse0.84885251
116NFIB_24661679_ChIP-Seq_LUNG_Mouse0.84569763
117* STAT1_20625510_ChIP-Seq_HELA_Human0.84324549
118GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.83722051
119* TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.83524288
120RUNX1_20887958_ChIP-Seq_HPC-7_Mouse0.83408202
121SUZ12_18555785_ChIP-Seq_MESCs_Mouse0.82899932
122SOX2_20726797_ChIP-Seq_SW620_Human0.81940276
123GBX2_23144817_ChIP-Seq_PC3_Human0.79933783
124EGR1_19032775_ChIP-ChIP_M12_Human0.79811836
125* KDM2B_26808549_Chip-Seq_SIL-ALL_Human0.79407308
126SUZ12_18692474_ChIP-Seq_MESCs_Mouse0.78544203
127KLF5_25053715_ChIP-Seq_YYC3_Human0.77834209
128DNAJC2_21179169_ChIP-ChIP_NT2_Human0.77798866
129CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.76913740
130SMAD2/3_21741376_ChIP-Seq_ESCs_Human0.76563305
131PPARA_22158963_ChIP-Seq_LIVER_Mouse0.75563198
132SA1_27219007_Chip-Seq_ERYTHROID_Human0.75273593
133LYL1_20887958_ChIP-Seq_HPC-7_Mouse0.75157669
134EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human0.74773828
135TP53_16413492_ChIP-PET_HCT116_Human0.74633731
136P300_27058665_Chip-Seq_ZR-75-30cells_Human0.74377922
137SUZ12_27294783_Chip-Seq_ESCs_Mouse0.73791993
138KDM2B_26808549_Chip-Seq_JURKAT_Human0.72630246
139AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.72430784
140NRF2_20460467_ChIP-Seq_MEFs_Mouse0.72416154
141NFE2L2_20460467_ChIP-Seq_MEFs_Mouse0.72416154
142RUNX1_27514584_Chip-Seq_MCF-7_Human0.72246867

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005058_abnormal_lysosome_morphology4.86382776
2MP0003183_abnormal_peptide_metabolism4.69461378
3MP0000569_abnormal_digit_pigmentation3.96113653
4MP0003172_abnormal_lysosome_physiology3.88950731
5MP0009840_abnormal_foam_cell3.16987642
6MP0003300_gastrointestinal_ulcer3.00879136
7MP0003303_peritoneal_inflammation2.70509763
8MP0004043_abnormal_pH_regulation2.42269438
9MP0003690_abnormal_glial_cell2.34606029
10MP0009764_decreased_sensitivity_to2.24912961
11MP0000604_amyloidosis2.14842688
12MP0005360_urolithiasis2.13694988
13MP0000920_abnormal_myelination1.99023602
14MP0005451_abnormal_body_composition1.97439313
15MP0006082_CNS_inflammation1.89048778
16MP0003191_abnormal_cellular_cholesterol1.88299076
17MP0004510_myositis1.86646646
18MP0002419_abnormal_innate_immunity1.85872570
19MP0001835_abnormal_antigen_presentation1.82245754
20MP0005174_abnormal_tail_pigmentation1.82171421
21MP0009780_abnormal_chondrocyte_physiolo1.81694887
22MP0001790_abnormal_immune_system1.80097869
23MP0005387_immune_system_phenotype1.80097869
24MP0003436_decreased_susceptibility_to1.77342453
25MP0005310_abnormal_salivary_gland1.75770750
26MP0000343_altered_response_to1.74661535
27MP0002909_abnormal_adrenal_gland1.67569107
28MP0001666_abnormal_nutrient_absorption1.67470013
29MP0005000_abnormal_immune_tolerance1.55465955
30MP0010386_abnormal_urinary_bladder1.54401932
31MP0004947_skin_inflammation1.52754282
32MP0003866_abnormal_defecation1.49659507
33MP0005464_abnormal_platelet_physiology1.49193671
34MP0005397_hematopoietic_system_phenotyp1.45277226
35MP0001545_abnormal_hematopoietic_system1.45277226
36MP0000015_abnormal_ear_pigmentation1.34333368
37MP0004270_analgesia1.34282986
38MP0003634_abnormal_glial_cell1.34174394
39MP0002693_abnormal_pancreas_physiology1.34172757
40MP0003075_altered_response_to1.33324963
41MP0002452_abnormal_antigen_presenting1.32208837
42MP0009333_abnormal_splenocyte_physiolog1.32149212
43MP0005167_abnormal_blood-brain_barrier1.31708282
44MP0005025_abnormal_response_to1.28769741
45MP0002139_abnormal_hepatobiliary_system1.28497702
46MP0001853_heart_inflammation1.28267019
47MP0008961_abnormal_basal_metabolism1.26160218
48MP0005257_abnormal_intraocular_pressure1.25042512
49MP0008260_abnormal_autophagy1.23982741
50MP0002723_abnormal_immune_serum1.22292802
51MP0002398_abnormal_bone_marrow1.21212489
52MP0008004_abnormal_stomach_pH1.20515671
53MP0004859_abnormal_synaptic_plasticity1.19504443
54MP0001800_abnormal_humoral_immune1.19452650
55MP0003828_pulmonary_edema1.19005307
56MP0003329_amyloid_beta_deposits1.18972026
57MP0003045_fibrosis1.18825432
58MP0000858_altered_metastatic_potential1.18127909
59MP0003448_altered_tumor_morphology1.16403371
60MP0001533_abnormal_skeleton_physiology1.13882046
61MP0002277_abnormal_respiratory_mucosa1.12364088
62MP0001765_abnormal_ion_homeostasis1.11903605
63MP0000685_abnormal_immune_system1.11080463
64MP0003806_abnormal_nucleotide_metabolis1.10926692
65MP0002148_abnormal_hypersensitivity_rea1.10086833
66MP0001819_abnormal_immune_cell1.09470384
67MP0002420_abnormal_adaptive_immunity1.08880647
68MP0003633_abnormal_nervous_system1.07625004
69MP0000689_abnormal_spleen_morphology1.07568073
70MP0001958_emphysema1.07164730
71MP0002998_abnormal_bone_remodeling1.07006805
72MP0002429_abnormal_blood_cell1.06692732
73MP0003453_abnormal_keratinocyte_physiol1.04322341
74MP0009278_abnormal_bone_marrow1.04099832
75MP0002138_abnormal_hepatobiliary_system1.03862084
76MP0009643_abnormal_urine_homeostasis1.03543654
77MP0003656_abnormal_erythrocyte_physiolo1.03257572
78MP0001845_abnormal_inflammatory_respons1.02070716
79MP0005671_abnormal_response_to1.01692754
80MP0004264_abnormal_extraembryonic_tissu1.01262555
81MP0003879_abnormal_hair_cell0.99382853
82MP0001851_eye_inflammation0.99069137
83MP0006054_spinal_hemorrhage0.98673845
84MP0002722_abnormal_immune_system0.98324466
85MP0002332_abnormal_exercise_endurance0.97515558
86MP0000538_abnormal_urinary_bladder0.97254334
87MP0005164_abnormal_response_to0.96830092
88MP0002229_neurodegeneration0.95373596
89MP0009046_muscle_twitch0.93633174
90MP0004883_abnormal_blood_vessel0.92816440
91MP0004885_abnormal_endolymph0.92224087
92MP0002064_seizures0.92212589
93MP0003763_abnormal_thymus_physiology0.92106730
94MP0003283_abnormal_digestive_organ0.91819758
95MP0008569_lethality_at_weaning0.90198965
96MP0003195_calcinosis0.89769603
97MP0010678_abnormal_skin_adnexa0.89204627
98MP0005166_decreased_susceptibility_to0.89146478
99MP0004742_abnormal_vestibular_system0.89081257
100MP0005409_darkened_coat_color0.88927478
101MP0010155_abnormal_intestine_physiology0.85224254
102MP0005390_skeleton_phenotype0.84443210
103MP0000462_abnormal_digestive_system0.83955239
104MP0008469_abnormal_protein_level0.83592035
105MP0002136_abnormal_kidney_physiology0.83304448
106MP0000383_abnormal_hair_follicle0.83165888
107MP0002254_reproductive_system_inflammat0.82258813
108MP0002405_respiratory_system_inflammati0.82178693
109MP0004858_abnormal_nervous_system0.82081537
110MP0009763_increased_sensitivity_to0.81953204
111MP0003252_abnormal_bile_duct0.81467795
112MP0009785_altered_susceptibility_to0.80987967
113MP0001756_abnormal_urination0.80669185
114MP0009765_abnormal_xenobiotic_induced0.80476598
115MP0002877_abnormal_melanocyte_morpholog0.78947469
116MP0002078_abnormal_glucose_homeostasis0.78494624
117MP0004019_abnormal_vitamin_homeostasis0.78283002
118MP0002090_abnormal_vision0.78158325
119MP0000465_gastrointestinal_hemorrhage0.75303320
120MP0001873_stomach_inflammation0.73760009
121MP0010329_abnormal_lipoprotein_level0.73713786
122MP0000716_abnormal_immune_system0.72477965
123MP0008874_decreased_physiological_sensi0.72356101
124MP0005381_digestive/alimentary_phenotyp0.71864015
125MP0001663_abnormal_digestive_system0.71372689
126MP0003795_abnormal_bone_structure0.69217737
127MP0002118_abnormal_lipid_homeostasis0.69206518
128MP0003724_increased_susceptibility_to0.68277598
129MP0002928_abnormal_bile_duct0.67786160
130MP0003631_nervous_system_phenotype0.67757480
131MP0000003_abnormal_adipose_tissue0.67602377
132MP0002933_joint_inflammation0.66889783
133MP0001849_ear_inflammation0.66587277
134MP0000249_abnormal_blood_vessel0.66178717
135MP0002132_abnormal_respiratory_system0.64325226
136MP0005535_abnormal_body_temperature0.62813664
137MP0001501_abnormal_sleep_pattern0.60907738
138MP0003646_muscle_fatigue0.59805623
139MP0005319_abnormal_enzyme/_coenzyme0.58042533
140MP0000371_diluted_coat_color0.57533550
141MP0005076_abnormal_cell_differentiation0.55326540
142MP0000703_abnormal_thymus_morphology0.55067121
143MP0005647_abnormal_sex_gland0.54412985

Predicted human phenotypes

RankGene SetZ-score
1Increased cerebral lipofuscin (HP:0011813)5.15074508
2Orchitis (HP:0100796)5.11762814
3Dysostosis multiplex (HP:0000943)5.11080074
4Myositis (HP:0100614)4.98842116
5Retrobulbar optic neuritis (HP:0100654)4.93997707
6Optic neuritis (HP:0100653)4.93997707
7Vacuolated lymphocytes (HP:0001922)4.79727316
8Urinary glycosaminoglycan excretion (HP:0003541)4.54810684
9Mucopolysacchariduria (HP:0008155)4.54810684
10Abnormality of mucopolysaccharide metabolism (HP:0011020)4.47778248
11Abnormality of polysaccharide metabolism (HP:0011012)4.47778248
12Abnormality of glycosaminoglycan metabolism (HP:0004371)4.47778248
13Abnormality of liposaccharide metabolism (HP:0010968)4.40759961
14Abnormality of glycosphingolipid metabolism (HP:0004343)4.40759961
15Abnormality of glycolipid metabolism (HP:0010969)4.40759961
16Increased neuronal autofluorescent lipopigment (HP:0002074)4.17956128
17Recurrent abscess formation (HP:0002722)4.10077660
18Mediastinal lymphadenopathy (HP:0100721)4.05743272
19Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)3.95175808
20Supranuclear gaze palsy (HP:0000605)3.85476997
21Neurofibrillary tangles (HP:0002185)3.85236894
22Elevated erythrocyte sedimentation rate (HP:0003565)3.69352666
23Recurrent bacterial skin infections (HP:0005406)3.65307853
24Abnormality of macrophages (HP:0004311)3.56511029
25Keratoconjunctivitis sicca (HP:0001097)3.32508558
26Axonal loss (HP:0003447)3.32149741
27Loss of speech (HP:0002371)3.31565840
28Eczematoid dermatitis (HP:0000976)3.22484733
29Keratoconjunctivitis (HP:0001096)3.13163939
30Systemic lupus erythematosus (HP:0002725)3.12420550
31Gastrointestinal infarctions (HP:0005244)3.11338730
32Vasculitis (HP:0002633)3.06085284
33Cerebral inclusion bodies (HP:0100314)3.04396662
34Hemoptysis (HP:0002105)2.99919333
35Meningitis (HP:0001287)2.95820849
36Spontaneous hematomas (HP:0007420)2.95145173
37Autoimmune thrombocytopenia (HP:0001973)2.93429893
38Neuronal loss in central nervous system (HP:0002529)2.91790361
39Pulmonary infiltrates (HP:0002113)2.91718569
40Encephalitis (HP:0002383)2.81994751
41Gingivitis (HP:0000230)2.78564818
42Increased serum ferritin (HP:0003281)2.70314523
43Elevated circulating parathyroid hormone (PTH) level (HP:0003165)2.67991741
44Urticaria (HP:0001025)2.65846583
45Tetany (HP:0001281)2.64400085
46Episodic fever (HP:0001954)2.59324079
47Peripheral demyelination (HP:0011096)2.58995392
48Disinhibition (HP:0000734)2.58926174
49Chronic mucocutaneous candidiasis (HP:0002728)2.53697907
50Recurrent cutaneous fungal infections (HP:0011370)2.53697907
51Petechiae (HP:0000967)2.47523721
52Increased IgE level (HP:0003212)2.47482639
53Retinal atrophy (HP:0001105)2.44148143
54Recurrent gram-negative bacterial infections (HP:0005420)2.41724967
55Purpura (HP:0000979)2.39862342
56Increased circulating renin level (HP:0000848)2.39368304
57Leukocytosis (HP:0001974)2.35184978
58Arterial thrombosis (HP:0004420)2.34922878
59Hyperactive renin-angiotensin system (HP:0000841)2.33978962
60Gangrene (HP:0100758)2.31889445
61Anorexia (HP:0002039)2.29721041
62Global brain atrophy (HP:0002283)2.29469976
63Pulmonary embolism (HP:0002204)2.29302227
64Polyneuropathy (HP:0001271)2.26714268
65Asymmetric septal hypertrophy (HP:0001670)2.26264399
66Abnormality of iron homeostasis (HP:0011031)2.26035343
67Slow saccadic eye movements (HP:0000514)2.25722305
68Abnormal delayed hypersensitivity skin test (HP:0002963)2.25603197
69Chest pain (HP:0100749)2.25515009
70Interstitial pulmonary disease (HP:0006530)2.25492472
71T lymphocytopenia (HP:0005403)2.24846359
72Abnormality of chloride homeostasis (HP:0011422)2.21947295
73Hypokalemic alkalosis (HP:0001949)2.21643104
74Metabolic alkalosis (HP:0200114)2.21295682
75Abnormality of renin-angiotensin system (HP:0000847)2.18370694
76Recurrent skin infections (HP:0001581)2.17906689
77Malnutrition (HP:0004395)2.17872413
78Increased IgM level (HP:0003496)2.17040809
79Increased CSF protein (HP:0002922)2.16261143
80Recurrent fungal infections (HP:0002841)2.15575142
81Colitis (HP:0002583)2.15448574
82Glomerulonephritis (HP:0000099)2.14294993
83Cellulitis (HP:0100658)2.11968883
84J-shaped sella turcica (HP:0002680)2.10264149
85Abnormality of T cell number (HP:0011839)2.10182157
86Vertigo (HP:0002321)2.08314912
87Abnormality of the pleura (HP:0002103)2.07884574
88Pustule (HP:0200039)2.05827322
89Decreased circulating renin level (HP:0003351)2.03784598
90Amyloidosis (HP:0011034)2.00857605
91Hypophosphatemia (HP:0002148)2.00812876
92Hepatosplenomegaly (HP:0001433)1.99644955
93Progressive visual loss (HP:0000529)1.98875716
94Recurrent viral infections (HP:0004429)1.98857703
95Inflammation of the large intestine (HP:0002037)1.98082343
96Acne (HP:0001061)1.97759696
97Prolonged bleeding time (HP:0003010)1.97533471
98Agnosia (HP:0010524)1.96509112
99Stomatitis (HP:0010280)1.96385218
100Mutism (HP:0002300)1.96357550
101Abnormality of transition element cation homeostasis (HP:0011030)1.94766363
102Diplopia (HP:0000651)1.94697555
103Abnormality of binocular vision (HP:0011514)1.94697555
104Abdominal distention (HP:0003270)1.93499519
105Memory impairment (HP:0002354)1.93470805
106Hydroxyprolinuria (HP:0003080)1.92399982
107Abnormality of proline metabolism (HP:0010907)1.92399982
108Myocardial infarction (HP:0001658)1.91919960
109Abnormality of the endocardium (HP:0004306)1.91687786
110Thyroiditis (HP:0100646)1.91296087
111Conjugated hyperbilirubinemia (HP:0002908)1.89206481
112Protuberant abdomen (HP:0001538)1.88736372
113Abnormality of the vasculature of the conjunctiva (HP:0008054)1.87845151
114Premature loss of primary teeth (HP:0006323)1.87388173
115Nuclear cataract (HP:0100018)1.87142537
116Apathy (HP:0000741)1.85923052
117Abnormality of the pericardium (HP:0001697)1.85365893
118Hematochezia (HP:0002573)1.84388879
119Epistaxis (HP:0000421)1.84238396
120Gastrointestinal inflammation (HP:0004386)1.82637986
121Thoracic kyphosis (HP:0002942)1.81907933
122Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)1.81853519
123Clumsiness (HP:0002312)1.81308527
124Progressive neurologic deterioration (HP:0002344)1.78870238
125Papilledema (HP:0001085)1.75769615
126Thick nail (HP:0001805)1.73844773
127Pathologic fracture (HP:0002756)1.72399486
128Onion bulb formation (HP:0003383)1.71859653
129Diminished motivation (HP:0000745)1.71777268
130Macroorchidism (HP:0000053)1.71279144
131Ovoid vertebral bodies (HP:0003300)1.69679209
132Psychosis (HP:0000709)1.69300993
133Obstructive lung disease (HP:0006536)1.68532186
134Chronic obstructive pulmonary disease (HP:0006510)1.68532186
135Abnormal urine output (HP:0012590)1.68116084
136Neurodegeneration (HP:0002180)1.67618997
137Chronic otitis media (HP:0000389)1.65729748
138Bone pain (HP:0002653)1.65206560
139Spastic tetraparesis (HP:0001285)1.62458165
140Dementia (HP:0000726)1.61653946
141Periodontitis (HP:0000704)1.61487191
142Frequent falls (HP:0002359)1.61418645
143Hypokalemia (HP:0002900)1.60695819
144Akinesia (HP:0002304)1.60513447
145Hyperinsulinemic hypoglycemia (HP:0000825)1.60095222
146Intention tremor (HP:0002080)1.59696944
147Coarse hair (HP:0002208)1.59445036
148Abnormality of renal excretion (HP:0011036)1.58512385
149Postural instability (HP:0002172)1.58438639
150Restrictive lung disease (HP:0002091)1.56764099
151Inappropriate behavior (HP:0000719)1.55806865
152Abnormal drinking behavior (HP:0030082)1.55573157
153Polydipsia (HP:0001959)1.55573157

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TAOK33.11958544
2RIPK42.93495615
3EPHB12.40271125
4CAMK1G2.23732840
5INSRR2.22736865
6MAP3K112.18743532
7MATK2.17151556
8ERN12.15105927
9MAP2K32.08973218
10RIPK12.00468190
11MAP3K21.98062304
12CAMK1D1.95468626
13IRAK31.94464380
14MAP3K31.84787942
15TAOK21.79675732
16PTK61.78952298
17TXK1.76916847
18FES1.75599480
19MAP4K11.74010555
20GRK71.73780318
21TYK21.63129947
22TNK21.61475421
23BLK1.51418004
24KIT1.49665166
25IRAK41.48003297
26MAP3K131.47227095
27SIK21.46785801
28WNK41.46601558
29TBK11.42420956
30JAK11.41130595
31OXSR11.39023779
32ACVR1B1.38118053
33FRK1.36781826
34MAP3K91.35749988
35HIPK21.34188576
36WNK11.34029750
37MAP3K141.30026657
38DDR21.29943934
39CAMKK21.27759137
40GRK61.27601277
41DAPK21.25538689
42PRKCH1.24813214
43MAP3K11.23388716
44NTRK11.23043235
45MAP3K101.22478265
46KSR21.18787716
47ITK1.17010955
48CDC42BPA1.16900062
49SIK31.15873001
50IRAK11.14982776
51HCK1.13531091
52SCYL21.13092020
53NME21.12550444
54ADRBK21.11290801
55IRAK21.09635909
56STK391.08156299
57FGR1.06576105
58MAPK151.03803536
59TGFBR21.03433444
60CSK1.02967608
61CSF1R1.02777766
62JAK21.00855365
63PDPK11.00146268
64IKBKE0.98396031
65SGK30.98324144
66BMPR20.97654348
67ZAP700.94823489
68CHUK0.94074064
69MARK30.91592880
70PDGFRB0.91213013
71TRIB30.90135567
72SYK0.89825632
73MARK20.89210874
74SGK4940.88916813
75SGK2230.88916813
76CAMKK10.86529282
77FYN0.84328487
78ICK0.83997612
79PTK20.81217401
80PDK10.80984800
81PRKD20.80331312
82LCK0.79580901
83PKN10.78391153
84MST40.76981068
85TESK20.74846534
86MAP2K60.73832860
87PAK60.72528843
88EPHA30.70174889
89RET0.70103107
90BTK0.68865538
91PRKD30.68076367
92PRKG20.67876190
93EGFR0.67547806
94LMTK20.67256757
95CLK10.67139932
96CDK120.67128212
97MET0.65982796
98MAP3K70.65203310
99MAP3K50.64028002
100PIM20.61432722
101MOS0.60042121
102CDK50.59680899
103RPS6KL10.59534063
104RPS6KC10.59534063
105PRKD10.59183318
106SIK10.58595262
107DYRK1B0.57199461
108RPS6KA60.56949894
109TYRO30.56710869
110FGFR30.54780302
111SGK20.54632024
112PRPF4B0.54475250
113TAOK10.50126583
114RPS6KA20.49239968
115MAPK120.48624911
116SGK10.48601991
117ABL20.47710012
118STK110.47700328
119PRKCQ0.46843344
120DMPK0.46622417
121MST1R0.45514791
122MAPK70.45436477
123LYN0.45242317
124MAP2K20.44840851
125SRC0.44784836
126GSK3A0.44219394
127STK100.43696642
128STK380.42677486
129ABL10.42270759
130JAK30.42258733
131PIM10.42025733
132WNK30.41582976
133YES10.41529645
134BRD40.41515321
135BMX0.41055959
136IKBKB0.40723465
137MAPK40.37380934
138MAP2K40.35627844
139PRKCZ0.33589579
140STK240.31576167
141KSR10.29557036
142PRKAA20.27413751
143PRKCD0.27175859

Predicted pathways (KEGG)

RankGene SetZ-score
1Glycosaminoglycan degradation_Homo sapiens_hsa005312.75305581
2Lysosome_Homo sapiens_hsa041422.69312680
3Carbohydrate digestion and absorption_Homo sapiens_hsa049732.35618054
4Allograft rejection_Homo sapiens_hsa053302.33767477
5Graft-versus-host disease_Homo sapiens_hsa053322.28459642
6Butirosin and neomycin biosynthesis_Homo sapiens_hsa005242.20743864
7Other glycan degradation_Homo sapiens_hsa005112.10288148
8Maturity onset diabetes of the young_Homo sapiens_hsa049502.07291586
9Inflammatory bowel disease (IBD)_Homo sapiens_hsa053212.02277875
10Mineral absorption_Homo sapiens_hsa049782.02037329
11Autoimmune thyroid disease_Homo sapiens_hsa053201.96347124
12Type I diabetes mellitus_Homo sapiens_hsa049401.86863353
13Legionellosis_Homo sapiens_hsa051341.85956940
14Type II diabetes mellitus_Homo sapiens_hsa049301.83281791
15Asthma_Homo sapiens_hsa053101.81539440
16Intestinal immune network for IgA production_Homo sapiens_hsa046721.80506369
17Renin-angiotensin system_Homo sapiens_hsa046141.71682085
18Sphingolipid metabolism_Homo sapiens_hsa006001.55200635
19RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.52849688
20Caffeine metabolism_Homo sapiens_hsa002321.47925000
21Osteoclast differentiation_Homo sapiens_hsa043801.44286428
22Influenza A_Homo sapiens_hsa051641.43318688
23African trypanosomiasis_Homo sapiens_hsa051431.41401720
24Antigen processing and presentation_Homo sapiens_hsa046121.40968763
25Fat digestion and absorption_Homo sapiens_hsa049751.40764732
26Collecting duct acid secretion_Homo sapiens_hsa049661.37353962
27Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.31317059
28Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.29743969
29Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.25929685
30Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.24971951
31B cell receptor signaling pathway_Homo sapiens_hsa046621.24724562
32Insulin secretion_Homo sapiens_hsa049111.23998767
33Measles_Homo sapiens_hsa051621.23962241
34Staphylococcus aureus infection_Homo sapiens_hsa051501.23697465
35Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.22686329
36Tuberculosis_Homo sapiens_hsa051521.20408401
37Jak-STAT signaling pathway_Homo sapiens_hsa046301.19893493
38Phosphatidylinositol signaling system_Homo sapiens_hsa040701.18276949
39Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.17361011
40Leishmaniasis_Homo sapiens_hsa051401.14562175
41Synaptic vesicle cycle_Homo sapiens_hsa047211.13758182
42Primary immunodeficiency_Homo sapiens_hsa053401.13526436
43Acute myeloid leukemia_Homo sapiens_hsa052211.11545476
44Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.10856086
45Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.09644243
46Viral myocarditis_Homo sapiens_hsa054161.08302077
47Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.07750668
48Herpes simplex infection_Homo sapiens_hsa051681.06501581
49Phagosome_Homo sapiens_hsa041451.06226693
50Toll-like receptor signaling pathway_Homo sapiens_hsa046201.05790389
51Vitamin digestion and absorption_Homo sapiens_hsa049771.04798281
52Dorso-ventral axis formation_Homo sapiens_hsa043201.02895211
53Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.01683441
54Gastric acid secretion_Homo sapiens_hsa049711.01442413
55Pertussis_Homo sapiens_hsa051331.00623590
56Vibrio cholerae infection_Homo sapiens_hsa051100.97829164
57ABC transporters_Homo sapiens_hsa020100.92809999
58Chemokine signaling pathway_Homo sapiens_hsa040620.92693677
59Hepatitis B_Homo sapiens_hsa051610.91019612
60Rheumatoid arthritis_Homo sapiens_hsa053230.89332442
61Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.89082294
62Pancreatic secretion_Homo sapiens_hsa049720.87910324
63Thyroid hormone synthesis_Homo sapiens_hsa049180.87798674
64Shigellosis_Homo sapiens_hsa051310.87391453
65Endocytosis_Homo sapiens_hsa041440.85952889
66Inositol phosphate metabolism_Homo sapiens_hsa005620.85255440
67Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.84867242
68Bile secretion_Homo sapiens_hsa049760.84360137
69Adipocytokine signaling pathway_Homo sapiens_hsa049200.82514975
70Sphingolipid signaling pathway_Homo sapiens_hsa040710.81312156
71Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.81200383
72Renin secretion_Homo sapiens_hsa049240.80291512
73Salivary secretion_Homo sapiens_hsa049700.77819789
74Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.75763218
75Salmonella infection_Homo sapiens_hsa051320.74678481
76Phospholipase D signaling pathway_Homo sapiens_hsa040720.74556696
77Galactose metabolism_Homo sapiens_hsa000520.73645386
78Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.72651341
79Leukocyte transendothelial migration_Homo sapiens_hsa046700.72341056
80Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.70884207
81Morphine addiction_Homo sapiens_hsa050320.70661455
82Protein digestion and absorption_Homo sapiens_hsa049740.69871954
83Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.69847368
84Prion diseases_Homo sapiens_hsa050200.69723925
85AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.69410497
86Starch and sucrose metabolism_Homo sapiens_hsa005000.69018487
87Bladder cancer_Homo sapiens_hsa052190.67298406
88Cholinergic synapse_Homo sapiens_hsa047250.67072708
89Aldosterone synthesis and secretion_Homo sapiens_hsa049250.66574045
90NF-kappa B signaling pathway_Homo sapiens_hsa040640.64379177
91Insulin resistance_Homo sapiens_hsa049310.63930425
92Renal cell carcinoma_Homo sapiens_hsa052110.63649254
93Neurotrophin signaling pathway_Homo sapiens_hsa047220.63133745
94T cell receptor signaling pathway_Homo sapiens_hsa046600.62843145
95Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.61704981
96Toxoplasmosis_Homo sapiens_hsa051450.60298739
97NOD-like receptor signaling pathway_Homo sapiens_hsa046210.60164575
98Cocaine addiction_Homo sapiens_hsa050300.59809766
99Malaria_Homo sapiens_hsa051440.59430537
100Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.58886868
101Chronic myeloid leukemia_Homo sapiens_hsa052200.58793656
102Olfactory transduction_Homo sapiens_hsa047400.57997085
103Circadian entrainment_Homo sapiens_hsa047130.57323158
104Choline metabolism in cancer_Homo sapiens_hsa052310.56913163
105Hematopoietic cell lineage_Homo sapiens_hsa046400.56899278
106Hepatitis C_Homo sapiens_hsa051600.56430212
107Glycerolipid metabolism_Homo sapiens_hsa005610.55638829
108Long-term potentiation_Homo sapiens_hsa047200.55378638
109Sulfur metabolism_Homo sapiens_hsa009200.55258649
110Glutamatergic synapse_Homo sapiens_hsa047240.55099789
111Estrogen signaling pathway_Homo sapiens_hsa049150.54966137
112Pancreatic cancer_Homo sapiens_hsa052120.52656286
113GABAergic synapse_Homo sapiens_hsa047270.52638444
114Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.52482663
115Long-term depression_Homo sapiens_hsa047300.50901835
116SNARE interactions in vesicular transport_Homo sapiens_hsa041300.50859344
117Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.50749192
118Glycerophospholipid metabolism_Homo sapiens_hsa005640.50564488
119VEGF signaling pathway_Homo sapiens_hsa043700.50444363
120Platelet activation_Homo sapiens_hsa046110.48925534
121GnRH signaling pathway_Homo sapiens_hsa049120.48777247
122Histidine metabolism_Homo sapiens_hsa003400.48515086
123cAMP signaling pathway_Homo sapiens_hsa040240.48141649
124Epstein-Barr virus infection_Homo sapiens_hsa051690.48071450
125Notch signaling pathway_Homo sapiens_hsa043300.47903534
126TNF signaling pathway_Homo sapiens_hsa046680.47259136
127Regulation of actin cytoskeleton_Homo sapiens_hsa048100.46833657
128Apoptosis_Homo sapiens_hsa042100.45650766
129cGMP-PKG signaling pathway_Homo sapiens_hsa040220.45623449
130Prolactin signaling pathway_Homo sapiens_hsa049170.45366446
131Taste transduction_Homo sapiens_hsa047420.44788898
132Amoebiasis_Homo sapiens_hsa051460.44530529
133Complement and coagulation cascades_Homo sapiens_hsa046100.43928277
134HIF-1 signaling pathway_Homo sapiens_hsa040660.39134068
135MAPK signaling pathway_Homo sapiens_hsa040100.37167680
136FoxO signaling pathway_Homo sapiens_hsa040680.36042908
137Non-small cell lung cancer_Homo sapiens_hsa052230.34770343
138Transcriptional misregulation in cancer_Homo sapiens_hsa052020.29632549
139PPAR signaling pathway_Homo sapiens_hsa033200.28448294
140mTOR signaling pathway_Homo sapiens_hsa041500.26000775
141Regulation of autophagy_Homo sapiens_hsa041400.22974677
142Ovarian steroidogenesis_Homo sapiens_hsa049130.22524586
143HTLV-I infection_Homo sapiens_hsa051660.20777611
144Viral carcinogenesis_Homo sapiens_hsa052030.20643112
145Rap1 signaling pathway_Homo sapiens_hsa040150.20189619

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