SLC43A3

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1protoporphyrinogen IX metabolic process (GO:0046501)5.88793667
2protoporphyrinogen IX biosynthetic process (GO:0006782)5.73290242
3heme biosynthetic process (GO:0006783)4.45418108
4regulation of vitamin D biosynthetic process (GO:0060556)4.43996076
5response to peptidoglycan (GO:0032494)4.24257202
6porphyrin-containing compound biosynthetic process (GO:0006779)4.21982417
7negative regulation of interleukin-12 production (GO:0032695)4.06383004
8lipopolysaccharide-mediated signaling pathway (GO:0031663)3.85524005
9tetrapyrrole biosynthetic process (GO:0033014)3.80345884
10NIK/NF-kappaB signaling (GO:0038061)3.77673419
11positive regulation of gamma-delta T cell activation (GO:0046645)3.68888494
12DNA strand elongation involved in DNA replication (GO:0006271)3.68884321
13immunoglobulin mediated immune response (GO:0016064)3.62604038
14blood vessel maturation (GO:0001955)3.61366315
15telomere maintenance via semi-conservative replication (GO:0032201)3.60383955
16positive regulation of interleukin-2 biosynthetic process (GO:0045086)3.54283740
17DNA strand elongation (GO:0022616)3.51028600
18DNA replication checkpoint (GO:0000076)3.49301110
19regulation of vitamin metabolic process (GO:0030656)3.47867725
20cellular response to thyroid hormone stimulus (GO:0097067)3.45359765
21positive regulation of chemokine biosynthetic process (GO:0045080)3.39886849
22heme metabolic process (GO:0042168)3.38262492
23protein localization to kinetochore (GO:0034501)3.37444500
24myeloid dendritic cell differentiation (GO:0043011)3.35377088
25definitive hemopoiesis (GO:0060216)3.32880054
26negative regulation of erythrocyte differentiation (GO:0045647)3.31772401
27porphyrin-containing compound metabolic process (GO:0006778)3.30814662
28DNA replication initiation (GO:0006270)3.30401337
29response to thyroid hormone (GO:0097066)3.25665977
30regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)3.24897495
31negative regulation of myeloid cell apoptotic process (GO:0033033)3.21575337
32type I interferon signaling pathway (GO:0060337)3.19445131
33cellular response to type I interferon (GO:0071357)3.19445131
34telomere maintenance via recombination (GO:0000722)3.18231280
35erythrocyte maturation (GO:0043249)3.17244239
36response to type I interferon (GO:0034340)3.15560180
37endothelial tube morphogenesis (GO:0061154)3.15312105
38morphogenesis of an endothelium (GO:0003159)3.15312105
39germinal center formation (GO:0002467)3.13552232
40T-helper 1 type immune response (GO:0042088)3.12842555
41response to protozoan (GO:0001562)3.12803391
42myeloid dendritic cell activation (GO:0001773)3.12755783
43pinocytosis (GO:0006907)3.12571404
44glycosphingolipid catabolic process (GO:0046479)3.12485591
45regulation of podosome assembly (GO:0071801)3.10964859
46lymph vessel development (GO:0001945)3.10712988
47macrophage activation involved in immune response (GO:0002281)3.07770950
48regulation of chemokine biosynthetic process (GO:0045073)3.03669194
49antigen processing and presentation of endogenous peptide antigen (GO:0002483)3.03572703
50antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)3.03572703
51protein localization to chromosome, centromeric region (GO:0071459)3.02936532
52regulation of chronic inflammatory response (GO:0002676)3.01685424
53vascular endothelial growth factor signaling pathway (GO:0038084)3.00399498
54mitotic recombination (GO:0006312)2.99898219
55regulation of cytokine secretion involved in immune response (GO:0002739)2.98917538
56positive regulation of respiratory burst (GO:0060267)2.98863552
57regulation of mononuclear cell migration (GO:0071675)2.98462874
58positive regulation by symbiont of host defense response (GO:0052509)2.98196313
59modulation by symbiont of host defense response (GO:0052031)2.98196313
60modulation by organism of immune response of other organism involved in symbiotic interaction (GO:002.98196313
61modulation by organism of defense response of other organism involved in symbiotic interaction (GO:02.98196313
62positive regulation by organism of defense response of other organism involved in symbiotic interact2.98196313
63modulation by symbiont of host immune response (GO:0052553)2.98196313
64attachment of spindle microtubules to kinetochore (GO:0008608)2.96916335
65regulation of interferon-alpha production (GO:0032647)2.96309455
66regulation of tumor necrosis factor biosynthetic process (GO:0042534)2.93916694
67B cell mediated immunity (GO:0019724)2.91856655
68positive regulation of syncytium formation by plasma membrane fusion (GO:0060143)2.91718219
69neutrophil activation involved in immune response (GO:0002283)2.91568447
70DNA unwinding involved in DNA replication (GO:0006268)2.89274765
71regulation of endothelial cell differentiation (GO:0045601)2.88989631
72interferon-gamma-mediated signaling pathway (GO:0060333)2.88916958
73regulation of T-helper 1 cell differentiation (GO:0045625)2.88747352
74regulation of spindle organization (GO:0090224)2.87578645
75keratan sulfate catabolic process (GO:0042340)2.86847730
76barbed-end actin filament capping (GO:0051016)2.85167503
77dendritic cell differentiation (GO:0097028)2.84449639
78mature B cell differentiation involved in immune response (GO:0002313)2.82677675
79folic acid metabolic process (GO:0046655)2.81919967
80regulation of type I interferon-mediated signaling pathway (GO:0060338)2.81477557
81positive regulation of membrane protein ectodomain proteolysis (GO:0051044)2.81400599
82mitotic metaphase plate congression (GO:0007080)2.79564532
83defense response to protozoan (GO:0042832)2.79511741
84nucleobase biosynthetic process (GO:0046112)2.78316794
85response to muramyl dipeptide (GO:0032495)2.77616671
86glycolipid catabolic process (GO:0019377)2.75068495
87regulation of interleukin-2 biosynthetic process (GO:0045076)2.73627312
88angiogenesis involved in wound healing (GO:0060055)2.73210055
89oligosaccharide catabolic process (GO:0009313)2.73206708
90CD4-positive or CD8-positive, alpha-beta T cell lineage commitment (GO:0043369)2.72571420
91mitotic nuclear envelope disassembly (GO:0007077)2.71956745
92response to folic acid (GO:0051593)2.71815328
93negative regulation of cytokine production involved in immune response (GO:0002719)2.70950131
94opsonization (GO:0008228)2.70414149
95surfactant homeostasis (GO:0043129)2.70071222
96cellular response to nitric oxide (GO:0071732)2.69889081
97purine nucleobase biosynthetic process (GO:0009113)2.69251056
98cellular response to arsenic-containing substance (GO:0071243)2.65413475
99regulation of interferon-gamma-mediated signaling pathway (GO:0060334)2.64453367
100cellular response to lipopolysaccharide (GO:0071222)2.64406595
101positive regulation of interferon-alpha production (GO:0032727)2.64155998
102negative regulation of inflammatory response to antigenic stimulus (GO:0002862)2.62768977
103positive regulation of vasculogenesis (GO:2001214)2.62410821
104response to xenobiotic stimulus (GO:0009410)2.61630629
105regulation of response to interferon-gamma (GO:0060330)2.61360908
106CENP-A containing nucleosome assembly (GO:0034080)2.61319676
107endothelium development (GO:0003158)2.59998651
108negative regulation of nitric-oxide synthase activity (GO:0051001)2.59030848
109positive regulation of B cell differentiation (GO:0045579)2.58995791
110amino sugar catabolic process (GO:0046348)2.58979120
111histone-serine phosphorylation (GO:0035404)2.58343675
112regulation of immunoglobulin secretion (GO:0051023)2.57830172
113telomere maintenance via telomere lengthening (GO:0010833)2.57306442
114antigen processing and presentation of endogenous antigen (GO:0019883)2.55352094
115positive regulation of endothelial cell differentiation (GO:0045603)2.53811951
116IMP biosynthetic process (GO:0006188)2.53674653
117regulation of interferon-beta biosynthetic process (GO:0045357)2.53052635
118cellular response to vascular endothelial growth factor stimulus (GO:0035924)2.52512000
119cellular response to molecule of bacterial origin (GO:0071219)2.52487702
120mitotic chromosome condensation (GO:0007076)2.52333702
121gas transport (GO:0015669)2.52201145
122venous blood vessel morphogenesis (GO:0048845)2.52060497
123regulation of membrane protein ectodomain proteolysis (GO:0051043)2.51051600
124T cell migration (GO:0072678)2.50561359
125protein localization to endosome (GO:0036010)2.49071975
126negative regulation of growth of symbiont in host (GO:0044130)2.48805804
127negative regulation of growth of symbiont involved in interaction with host (GO:0044146)2.48805804
128modulation of growth of symbiont involved in interaction with host (GO:0044144)2.48805804
129regulation of growth of symbiont in host (GO:0044126)2.48805804
130regulation of dendritic cell antigen processing and presentation (GO:0002604)2.47776017
131regulation of monocyte differentiation (GO:0045655)2.47577337
132valine metabolic process (GO:0006573)2.46539849
133modulation by symbiont of host cellular process (GO:0044068)2.45692115
134membrane disassembly (GO:0030397)2.45402379
135nuclear envelope disassembly (GO:0051081)2.45402379
136cellular response to interferon-gamma (GO:0071346)2.45333630
137regulation of interleukin-12 production (GO:0032655)2.44451225
138regulation of cholesterol storage (GO:0010885)2.43186067
139positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)2.42944687
140positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)2.42365639
141DNA deamination (GO:0045006)2.42102295
142regulation of gamma-delta T cell activation (GO:0046643)2.41762399
143cellular extravasation (GO:0045123)2.40740306
144retina vasculature morphogenesis in camera-type eye (GO:0061299)2.39466865
145monocyte chemotaxis (GO:0002548)2.39269750
146regulation of syncytium formation by plasma membrane fusion (GO:0060142)2.38599881
147low-density lipoprotein particle clearance (GO:0034383)2.38239459
148metaphase plate congression (GO:0051310)2.37902686
149regulation of inflammatory response to antigenic stimulus (GO:0002861)2.37486688
150myeloid cell activation involved in immune response (GO:0002275)2.36118123
151positive regulation of antigen processing and presentation (GO:0002579)2.34604024
152ceramide catabolic process (GO:0046514)2.34435061
153negative regulation of toll-like receptor 4 signaling pathway (GO:0034144)2.34237327
154ribosomal small subunit assembly (GO:0000028)2.34130928
155chromatin remodeling at centromere (GO:0031055)2.33999545
156regulation of mitotic spindle organization (GO:0060236)2.33963159
157positive regulation of natural killer cell differentiation (GO:0032825)2.33664190
158positive regulation of isotype switching (GO:0045830)2.33443163
159regulation of superoxide anion generation (GO:0032928)2.33440922
160regulation of B cell apoptotic process (GO:0002902)2.33435139
161negative regulation of nitric oxide biosynthetic process (GO:0045019)2.33335047
162peptide catabolic process (GO:0043171)2.33056379
163purine nucleotide salvage (GO:0032261)2.32245761
164positive regulation of granulocyte macrophage colony-stimulating factor production (GO:0032725)2.32090444
165response to interferon-gamma (GO:0034341)2.32064087
166DNA replication-independent nucleosome organization (GO:0034724)2.31873831
167DNA replication-independent nucleosome assembly (GO:0006336)2.31873831
168positive regulation of immunoglobulin mediated immune response (GO:0002891)2.31731635
169positive regulation of B cell mediated immunity (GO:0002714)2.31731635
170kinetochore organization (GO:0051383)2.30731384
171tetrapyrrole metabolic process (GO:0033013)2.30649565
172cellular response to cadmium ion (GO:0071276)2.29647270
173response to nitric oxide (GO:0071731)2.29315986
174IMP metabolic process (GO:0046040)2.29097178
175ovulation from ovarian follicle (GO:0001542)2.28169996
176negative regulation of phagocytosis (GO:0050765)2.26641506
177regulation of vasculogenesis (GO:2001212)2.26050481
178defense response to fungus (GO:0050832)2.25365539
179deoxyribonucleoside monophosphate metabolic process (GO:0009162)2.23561669
180regulation of complement activation (GO:0030449)2.22294668
181one-carbon compound transport (GO:0019755)2.21321808
182pigment biosynthetic process (GO:0046148)2.20117420
183homocysteine metabolic process (GO:0050667)2.19744839
184positive regulation of chromosome segregation (GO:0051984)2.19104569
185basement membrane organization (GO:0071711)2.18337977
186iron ion import (GO:0097286)2.17502599
187mitotic sister chromatid segregation (GO:0000070)2.17135178
188regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)2.16948740
189establishment of chromosome localization (GO:0051303)2.16171211
190nucleotide-excision repair, DNA gap filling (GO:0006297)2.15812133
191folic acid-containing compound biosynthetic process (GO:0009396)2.15428482
192lymphangiogenesis (GO:0001946)2.15310519
193hemoglobin metabolic process (GO:0020027)2.14032177
194regulation of integrin-mediated signaling pathway (GO:2001044)2.11718286
195erythrocyte differentiation (GO:0030218)2.11583594
196regulation of protein activation cascade (GO:2000257)2.10790918
197embryonic hemopoiesis (GO:0035162)2.10566282
198cellular hyperosmotic response (GO:0071474)2.09403145
199regulation of vascular endothelial growth factor signaling pathway (GO:1900746)2.08436647

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human8.22678062
2FOXM1_23109430_ChIP-Seq_U2OS_Human3.71132725
3EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.70827748
4PPARG_19300518_ChIP-PET_3T3-L1_Mouse3.42374114
5* GATA1_22025678_ChIP-Seq_K562_Human2.93599077
6E2F4_17652178_ChIP-ChIP_JURKAT_Human2.92690639
7FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.45813518
8ESR1_17901129_ChIP-ChIP_LIVER_Mouse2.41755927
9AR_21909140_ChIP-Seq_LNCAP_Human2.34800694
10EGR1_19374776_ChIP-ChIP_THP-1_Human2.31677150
11* SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse2.27461039
12MYC_18555785_ChIP-Seq_MESCs_Mouse2.23769845
13IRF8_27001747_Chip-Seq_BMDM_Mouse2.10804802
14IRF8_22096565_ChIP-ChIP_GC-B_Human2.00374327
15MYB_21317192_ChIP-Seq_ERMYB_Mouse1.89605278
16* SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.80564824
17E2F1_21310950_ChIP-Seq_MCF-7_Human1.76890089
18CLOCK_20551151_ChIP-Seq_293T_Human1.74843231
19KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.74342962
20SCL_19346495_ChIP-Seq_HPC-7_Human1.72413842
21VDR_21846776_ChIP-Seq_THP-1_Human1.63500024
22MYC_18358816_ChIP-ChIP_MESCs_Mouse1.62199747
23TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.59248362
24CREB1_15753290_ChIP-ChIP_HEK293T_Human1.56839106
25TFEB_21752829_ChIP-Seq_HELA_Human1.56805551
26ETS1_20019798_ChIP-Seq_JURKAT_Human1.54774282
27MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.54262703
28NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.54087679
29TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.53532883
30SPI1_23127762_ChIP-Seq_K562_Human1.52330399
31MYC_19030024_ChIP-ChIP_MESCs_Mouse1.51477351
32NELFA_20434984_ChIP-Seq_ESCs_Mouse1.50288862
33* MYC_22102868_ChIP-Seq_BL_Human1.49200114
34STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.48032564
35EST1_17652178_ChIP-ChIP_JURKAT_Human1.47838013
36RUNX1_22412390_ChIP-Seq_EML_Mouse1.47243856
37TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.46429808
38* GATA1_22383799_ChIP-Seq_G1ME_Mouse1.45979305
39GATA1_19941826_ChIP-Seq_K562_Human1.45907968
40* TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.43683920
41STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.43542124
42LXR_22292898_ChIP-Seq_THP-1_Human1.42755910
43RXR_22158963_ChIP-Seq_LIVER_Mouse1.42706280
44HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.42589205
45* ELK3_25401928_ChIP-Seq_HUVEC_Human1.41877384
46RARG_19884340_ChIP-ChIP_MEFs_Mouse1.41509282
47PPARA_22158963_ChIP-Seq_LIVER_Mouse1.41219215
48MYC_19079543_ChIP-ChIP_MESCs_Mouse1.40780219
49Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.40085245
50* NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.37520411
51TRIM28_21343339_ChIP-Seq_HEK293_Human1.37258911
52DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.35638876
53CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.35073327
54* KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.34953780
55JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.34780844
56IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.33774039
57* GATA1_19941827_ChIP-Seq_MEL_Mouse1.32565266
58MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.32202086
59STAT3_1855785_ChIP-Seq_MESCs_Mouse1.32019215
60BP1_19119308_ChIP-ChIP_Hs578T_Human1.30959912
61* BRD4_27068464_Chip-Seq_AML-cells_Mouse1.30703695
62E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.29749527
63ELF1_17652178_ChIP-ChIP_JURKAT_Human1.27549831
64VDR_23849224_ChIP-Seq_CD4+_Human1.26767628
65EGR1_23403033_ChIP-Seq_LIVER_Mouse1.25863083
66* MAF_26560356_Chip-Seq_TH2_Human1.25026884
67E2F1_18555785_ChIP-Seq_MESCs_Mouse1.24984254
68GABP_17652178_ChIP-ChIP_JURKAT_Human1.24517223
69CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.22843681
70HOXB4_20404135_ChIP-ChIP_EML_Mouse1.22246382
71PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.21942112
72* FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.21639809
73TCF7_22412390_ChIP-Seq_EML_Mouse1.20685768
74MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.20435526
75DCP1A_22483619_ChIP-Seq_HELA_Human1.19868472
76HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.18598212
77RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.18389118
78CIITA_25753668_ChIP-Seq_RAJI_Human1.18244286
79CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.17212069
80IRF8_21731497_ChIP-ChIP_J774_Mouse1.17142659
81ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.16466383
82XRN2_22483619_ChIP-Seq_HELA_Human1.15238145
83PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.14710236
84* MAF_26560356_Chip-Seq_TH1_Human1.13546733
85NKX2-5_21415370_ChIP-Seq_HL-1_Mouse1.13012920
86SRF_21415370_ChIP-Seq_HL-1_Mouse1.12345877
87STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.11660439
88SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.10823280
89FOXP3_21729870_ChIP-Seq_TREG_Human1.10665994
90GATA2_22383799_ChIP-Seq_G1ME_Mouse1.09839282
91* KDM2B_26808549_Chip-Seq_SUP-B15_Human1.09707433
92* ERG_20887958_ChIP-Seq_HPC-7_Mouse1.09459268
93SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.09284786
94GFI1B_20887958_ChIP-Seq_HPC-7_Mouse1.08933137
95ZNF263_19887448_ChIP-Seq_K562_Human1.08473435
96FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.08364093
97STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.08249257
98HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.08026168
99NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.06885054
100* CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.06748187
101SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.06346596
102* SPI1_23547873_ChIP-Seq_NB4_Human1.05431122
103CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.05015805
104* STAT4_19710469_ChIP-ChIP_TH1__Mouse1.03660571
105LXR_22158963_ChIP-Seq_LIVER_Mouse1.03123083
106* KDM2B_26808549_Chip-Seq_DND41_Human1.02476458
107* TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.02435781
108CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human1.01353671
109IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.01198938
110TP63_17297297_ChIP-ChIP_HaCaT_Human1.00683205
111TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.00199638
112* LMO2_20887958_ChIP-Seq_HPC-7_Mouse0.99197133
113SRY_22984422_ChIP-ChIP_TESTIS_Rat0.99193669
114PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse0.99038160
115NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse0.98709264
116PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse0.98450299
117CCND1_20090754_ChIP-ChIP_RETINA_Mouse0.98119958
118MYB_26560356_Chip-Seq_TH1_Human0.97636190
119* ELF1_20517297_ChIP-Seq_JURKAT_Human0.97600259
120HNF4A_19761587_ChIP-ChIP_CACO-2_Human0.97054279
121PU.1_20513432_ChIP-Seq_Bcells_Mouse0.97032736
122ELK1_19687146_ChIP-ChIP_HELA_Human0.96848701
123MYBL2_22936984_ChIP-ChIP_MESCs_Mouse0.95798445
124GABP_19822575_ChIP-Seq_HepG2_Human0.95238832
125GATA2_21666600_ChIP-Seq_HMVEC_Human0.95057998
126* UTX_26944678_Chip-Seq_JUKART_Human0.94727829
127NCOR1_26117541_ChIP-Seq_K562_Human0.94541810
128VDR_24763502_ChIP-Seq_THP-1_Human0.94357107
129CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human0.93816460
130NOTCH1_17114293_ChIP-ChIP_T-ALL_Human0.92959206
131* MYB_26560356_Chip-Seq_TH2_Human0.91523537
132RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human0.89961769

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004147_increased_porphyrin_level3.87167130
2MP0010368_abnormal_lymphatic_system3.46275490
3MP0008438_abnormal_cutaneous_collagen3.43938043
4MP0003656_abnormal_erythrocyte_physiolo3.17935971
5MP0005058_abnormal_lysosome_morphology3.13816056
6MP0003436_decreased_susceptibility_to3.12874997
7MP0002148_abnormal_hypersensitivity_rea2.90783374
8MP0006054_spinal_hemorrhage2.79382759
9MP0005503_abnormal_tendon_morphology2.75333080
10MP0005000_abnormal_immune_tolerance2.44108525
11MP0001879_abnormal_lymphatic_vessel2.42417247
12MP0005451_abnormal_body_composition2.42355042
13MP0005275_abnormal_skin_tensile2.40734923
14MP0003693_abnormal_embryo_hatching2.36130937
15MP0004510_myositis2.35151136
16MP0001790_abnormal_immune_system2.34102015
17MP0005387_immune_system_phenotype2.34102015
18MP0003724_increased_susceptibility_to2.31173546
19MP0002396_abnormal_hematopoietic_system2.30151022
20MP0006082_CNS_inflammation2.29446870
21MP0005671_abnormal_response_to2.19078751
22MP0003806_abnormal_nucleotide_metabolis2.15371974
23MP0003111_abnormal_nucleus_morphology2.03916953
24MP0002452_abnormal_antigen_presenting2.02814792
25MP0002723_abnormal_immune_serum1.94447541
26MP0001800_abnormal_humoral_immune1.93546940
27MP0001545_abnormal_hematopoietic_system1.92010709
28MP0005397_hematopoietic_system_phenotyp1.92010709
29MP0004947_skin_inflammation1.77913915
30MP0004272_abnormal_basement_membrane1.77800036
31MP0003075_altered_response_to1.75557992
32MP0002138_abnormal_hepatobiliary_system1.75153634
33MP0003172_abnormal_lysosome_physiology1.74199096
34MP0002420_abnormal_adaptive_immunity1.74061015
35MP0010094_abnormal_chromosome_stability1.73662470
36MP0001819_abnormal_immune_cell1.72448367
37MP0001958_emphysema1.68178086
38MP0003566_abnormal_cell_adhesion1.63370954
39MP0002405_respiratory_system_inflammati1.60659049
40MP0001845_abnormal_inflammatory_respons1.54366357
41MP0000604_amyloidosis1.52775557
42MP0003077_abnormal_cell_cycle1.49316310
43MP0003453_abnormal_keratinocyte_physiol1.47807872
44MP0004084_abnormal_cardiac_muscle1.46957096
45MP0003828_pulmonary_edema1.45727658
46MP0004957_abnormal_blastocyst_morpholog1.44212919
47MP0000858_altered_metastatic_potential1.41628651
48MP0003705_abnormal_hypodermis_morpholog1.38893003
49MP0000716_abnormal_immune_system1.38506733
50MP0002998_abnormal_bone_remodeling1.37469484
51MP0010155_abnormal_intestine_physiology1.35837086
52MP0004808_abnormal_hematopoietic_stem1.31334334
53MP0000343_altered_response_to1.28185841
54MP0003448_altered_tumor_morphology1.27239974
55MP0005023_abnormal_wound_healing1.26880875
56MP0003186_abnormal_redox_activity1.26026665
57MP0000749_muscle_degeneration1.26024078
58MP0002166_altered_tumor_susceptibility1.22448463
59MP0010352_gastrointestinal_tract_polyps1.22236166
60MP0003279_aneurysm1.21156024
61MP0003567_abnormal_fetal_cardiomyocyte1.19806393
62MP0000465_gastrointestinal_hemorrhage1.16350461
63MP0003191_abnormal_cellular_cholesterol1.14834532
64MP0000767_abnormal_smooth_muscle1.13891646
65MP0009840_abnormal_foam_cell1.13005414
66MP0008057_abnormal_DNA_replication1.12349018
67MP0005365_abnormal_bile_salt1.10893197
68MP0001661_extended_life_span1.10661535
69MP0000750_abnormal_muscle_regeneration1.10186574
70MP0000685_abnormal_immune_system1.09761826
71MP0002332_abnormal_exercise_endurance1.09589639
72MP0005310_abnormal_salivary_gland1.09510409
73MP0008775_abnormal_heart_ventricle1.09224566
74MP0009764_decreased_sensitivity_to1.08665361
75MP0005464_abnormal_platelet_physiology1.08215607
76MP0005166_decreased_susceptibility_to1.06841095
77MP0010307_abnormal_tumor_latency1.05577442
78MP0005330_cardiomyopathy1.04452375
79MP0009333_abnormal_splenocyte_physiolog1.03673188
80MP0000751_myopathy1.02817099
81MP0001544_abnormal_cardiovascular_syste1.01942019
82MP0005385_cardiovascular_system_phenoty1.01942019
83MP0002139_abnormal_hepatobiliary_system1.00876378
84MP0003300_gastrointestinal_ulcer0.99824929
85MP0009763_increased_sensitivity_to0.98361486
86MP0003091_abnormal_cell_migration0.97045544
87MP0001533_abnormal_skeleton_physiology0.96674142
88MP0005076_abnormal_cell_differentiation0.96090587
89MP0003221_abnormal_cardiomyocyte_apopto0.95503009
90MP0009785_altered_susceptibility_to0.93933721
91MP0000249_abnormal_blood_vessel0.93631225
92MP0001873_stomach_inflammation0.93600807
93MP0005319_abnormal_enzyme/_coenzyme0.93237737
94MP0002398_abnormal_bone_marrow0.92712913
95MP0009278_abnormal_bone_marrow0.92384772
96MP0002722_abnormal_immune_system0.91606434
97MP0000689_abnormal_spleen_morphology0.90977483
98MP0005360_urolithiasis0.90008572
99MP0004215_abnormal_myocardial_fiber0.89940311
100MP0008875_abnormal_xenobiotic_pharmacok0.89330139
101MP0001853_heart_inflammation0.88995410
102MP0001835_abnormal_antigen_presentation0.88523828
103MP0000609_abnormal_liver_physiology0.87883860
104MP0005167_abnormal_blood-brain_barrier0.87806558
105MP0005164_abnormal_response_to0.87612206
106MP0008260_abnormal_autophagy0.86727931
107MP0001756_abnormal_urination0.86705277
108MP0006138_congestive_heart_failure0.86466079
109MP0008007_abnormal_cellular_replicative0.85783943
110MP0002429_abnormal_blood_cell0.85682996
111MP0005670_abnormal_white_adipose0.84807473
112MP0003984_embryonic_growth_retardation0.83498738
113MP0002019_abnormal_tumor_incidence0.83380974
114MP0000490_abnormal_crypts_of0.83372218
115MP0003763_abnormal_thymus_physiology0.83358297
116MP0002128_abnormal_blood_circulation0.83306281
117MP0002060_abnormal_skin_morphology0.83266588
118MP0006036_abnormal_mitochondrial_physio0.82921784
119MP0002877_abnormal_melanocyte_morpholog0.82853697
120MP0010630_abnormal_cardiac_muscle0.82458091
121MP0005025_abnormal_response_to0.82234803
122MP0002088_abnormal_embryonic_growth/wei0.81230086
123MP0001730_embryonic_growth_arrest0.81219943
124MP0009643_abnormal_urine_homeostasis0.81218913
125MP0002254_reproductive_system_inflammat0.80300473
126MP0004782_abnormal_surfactant_physiolog0.80280268
127MP0000598_abnormal_liver_morphology0.80202127
128MP0002086_abnormal_extraembryonic_tissu0.80171813
129MP0001542_abnormal_bone_strength0.79974259
130MP0008469_abnormal_protein_level0.79563787
131MP0005165_increased_susceptibility_to0.79222859
132MP0002108_abnormal_muscle_morphology0.78884245
133MP0003950_abnormal_plasma_membrane0.78769545
134MP0002006_tumorigenesis0.78655039
135MP0003303_peritoneal_inflammation0.78226719
136MP0000703_abnormal_thymus_morphology0.77648202
137MP0002419_abnormal_innate_immunity0.77396146
138MP0001243_abnormal_dermal_layer0.77200761
139MP0010329_abnormal_lipoprotein_level0.76783440
140MP0001915_intracranial_hemorrhage0.74747646
141MP0008004_abnormal_stomach_pH0.71282553
142MP0000371_diluted_coat_color0.70045453
143MP0003795_abnormal_bone_structure0.69057359
144MP0005390_skeleton_phenotype0.65897831
145MP0000313_abnormal_cell_death0.65265222
146MP0009697_abnormal_copulation0.63419337
147MP0009765_abnormal_xenobiotic_induced0.61870749
148MP0005647_abnormal_sex_gland0.61134855

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of glycolipid metabolism (HP:0010969)5.73299985
2Abnormality of liposaccharide metabolism (HP:0010968)5.73299985
3Abnormality of glycosphingolipid metabolism (HP:0004343)5.73299985
4Abnormality of the heme biosynthetic pathway (HP:0010472)5.59969565
5Polycythemia (HP:0001901)4.96315018
6Poikilocytosis (HP:0004447)3.99971586
7Increased cerebral lipofuscin (HP:0011813)3.98517682
8Spontaneous hematomas (HP:0007420)3.85842431
9Systemic lupus erythematosus (HP:0002725)3.75988007
10Vacuolated lymphocytes (HP:0001922)3.75463978
11Abnormality of macrophages (HP:0004311)3.71863852
12Loss of speech (HP:0002371)3.58833883
13Ileus (HP:0002595)3.50766942
14Ankle contracture (HP:0006466)3.41677638
15Increased neuronal autofluorescent lipopigment (HP:0002074)3.38633752
16Dysostosis multiplex (HP:0000943)3.37848425
17Recurrent abscess formation (HP:0002722)3.28271070
18Nonimmune hydrops fetalis (HP:0001790)3.25247796
19Diaphragmatic weakness (HP:0009113)3.23112896
20Recurrent bacterial skin infections (HP:0005406)3.20078735
21Microcytic anemia (HP:0001935)3.15001453
22Hematochezia (HP:0002573)3.14521170
23Reduced subcutaneous adipose tissue (HP:0003758)3.14286451
24Nausea (HP:0002018)3.10196761
25Recurrent viral infections (HP:0004429)3.08958158
26Mediastinal lymphadenopathy (HP:0100721)3.07542721
27Protrusio acetabuli (HP:0003179)3.04432081
28Congenital, generalized hypertrichosis (HP:0004540)3.03838855
29Premature rupture of membranes (HP:0001788)2.94970587
30Cholecystitis (HP:0001082)2.88800818
31Abnormal gallbladder physiology (HP:0012438)2.88800818
32Abnormality of the nasal mucosa (HP:0000433)2.79449838
33Myocardial infarction (HP:0001658)2.78741308
34Hypoglycemic coma (HP:0001325)2.78518639
35Conjunctival telangiectasia (HP:0000524)2.74060588
36Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)2.72734244
37Orchitis (HP:0100796)2.71961777
38Petechiae (HP:0000967)2.67344954
39Cervical subluxation (HP:0003308)2.65639776
40Hepatosplenomegaly (HP:0001433)2.65306821
41Osteolytic defects of the hand bones (HP:0009699)2.63876404
42Osteolytic defects of the phalanges of the hand (HP:0009771)2.63876404
43Myositis (HP:0100614)2.62907552
44Increased connective tissue (HP:0009025)2.60856520
45Broad metatarsal (HP:0001783)2.54370306
46Birth length less than 3rd percentile (HP:0003561)2.53578481
47Disinhibition (HP:0000734)2.53556613
48Retrobulbar optic neuritis (HP:0100654)2.52685289
49Optic neuritis (HP:0100653)2.52685289
50Recurrent gram-negative bacterial infections (HP:0005420)2.52012067
51Chronic obstructive pulmonary disease (HP:0006510)2.51165508
52Obstructive lung disease (HP:0006536)2.51165508
53Abnormality of mucopolysaccharide metabolism (HP:0011020)2.45188149
54Abnormality of polysaccharide metabolism (HP:0011012)2.45188149
55Abnormality of glycosaminoglycan metabolism (HP:0004371)2.45188149
56Hypertensive crisis (HP:0100735)2.44817005
57Fatigue (HP:0012378)2.44660077
58Enlarged penis (HP:0000040)2.43459642
59Reticulocytosis (HP:0001923)2.43065949
60Hepatocellular carcinoma (HP:0001402)2.41016693
61Wrist flexion contracture (HP:0001239)2.40876366
62Recurrent fungal infections (HP:0002841)2.39525817
63Nuclear cataract (HP:0100018)2.38431513
64Stomatitis (HP:0010280)2.37426212
65Abnormality of the vasculature of the conjunctiva (HP:0008054)2.34154418
66Muscle fiber splitting (HP:0003555)2.28993631
67Mucopolysacchariduria (HP:0008155)2.28900674
68Urinary glycosaminoglycan excretion (HP:0003541)2.28900674
69Meningitis (HP:0001287)2.28771308
70Axonal loss (HP:0003447)2.28176887
71Esophageal varix (HP:0002040)2.27858059
72Abnormal number of erythroid precursors (HP:0012131)2.27851813
73Hypoplasia of the capital femoral epiphysis (HP:0003090)2.26880067
74Autoimmune hemolytic anemia (HP:0001890)2.26709836
75Upper motor neuron abnormality (HP:0002127)2.26157422
76Acanthocytosis (HP:0001927)2.23657009
77Elevated erythrocyte sedimentation rate (HP:0003565)2.23605291
78Increased IgM level (HP:0003496)2.23378321
79Increased IgE level (HP:0003212)2.21907862
80High pitched voice (HP:0001620)2.20818468
81Gastrointestinal stroma tumor (HP:0100723)2.18894352
82Abnormality of reticulocytes (HP:0004312)2.16860742
83Complement deficiency (HP:0004431)2.16685269
84Increased serum ferritin (HP:0003281)2.16340307
85Pancreatic islet-cell hyperplasia (HP:0004510)2.16177095
86Prolonged bleeding time (HP:0003010)2.15851589
87Deep venous thrombosis (HP:0002625)2.15188089
88Abnormality of complement system (HP:0005339)2.14371902
89Pulmonary infiltrates (HP:0002113)2.13975354
90Vasculitis (HP:0002633)2.13457901
91Glomerulonephritis (HP:0000099)2.11657813
92Hypertriglyceridemia (HP:0002155)2.08387683
93Ragged-red muscle fibers (HP:0003200)2.07805565
94Interstitial pulmonary disease (HP:0006530)2.07617550
95Lipoatrophy (HP:0100578)2.07524629
96IgA deficiency (HP:0002720)2.07173447
97Diminished motivation (HP:0000745)2.05849324
98Autoimmune thrombocytopenia (HP:0001973)2.05195380
99Breast hypoplasia (HP:0003187)2.05069343
100Neurofibrillary tangles (HP:0002185)2.04892992
101Apathy (HP:0000741)2.04617612
102Mucosal telangiectasiae (HP:0100579)2.03074888
103Mutism (HP:0002300)2.03031774
104B lymphocytopenia (HP:0010976)2.02849306
105Abnormality of cells of the erythroid lineage (HP:0012130)2.02579086
106Personality changes (HP:0000751)2.01448090
107Combined immunodeficiency (HP:0005387)2.00737902
108Epistaxis (HP:0000421)1.97972060
109Colitis (HP:0002583)1.97472134
110Hypochromic anemia (HP:0001931)1.97454560
111Hypochromic microcytic anemia (HP:0004840)1.97374707
112Neuronal loss in central nervous system (HP:0002529)1.97285630
113Recurrent skin infections (HP:0001581)1.96639288
114Neoplasm of head and neck (HP:0012288)1.95830236
115Esophageal neoplasm (HP:0100751)1.95830236
116Paralysis (HP:0003470)1.94874207
117Pustule (HP:0200039)1.94067069
118Abnormality of iron homeostasis (HP:0011031)1.92702110
119Hyperbilirubinemia (HP:0002904)1.92672162
120Hypergammaglobulinemia (HP:0010702)1.91530185
121Agammaglobulinemia (HP:0004432)1.90570643
122Keratoconjunctivitis sicca (HP:0001097)1.90272813
123Progressive neurologic deterioration (HP:0002344)1.89896041
124Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)1.89807033
125Thrombocytosis (HP:0001894)1.89323462
126Insulin resistance (HP:0000855)1.89114767
127Spinal rigidity (HP:0003306)1.88276012
128Abnormal platelet function (HP:0011869)1.88138551
129Impaired platelet aggregation (HP:0003540)1.88138551
130Cerebral aneurysm (HP:0004944)1.86593485
131Multiple enchondromatosis (HP:0005701)1.85641331
132Entropion (HP:0000621)1.84872908
133Mitral stenosis (HP:0001718)1.84806424
134Neonatal death (HP:0003811)1.84617317
135Amaurosis fugax (HP:0100576)1.84489205
136Ventricular tachycardia (HP:0004756)1.84311866
137Urticaria (HP:0001025)1.83611061
138Osteomyelitis (HP:0002754)1.83276240
139Thoracic kyphosis (HP:0002942)1.82822450
140Aortic aneurysm (HP:0004942)1.82764746
141Amyloidosis (HP:0011034)1.82656518
142Cholelithiasis (HP:0001081)1.82622046
143Abnormality of B cell number (HP:0010975)1.82465122
144Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)1.81964708
145Absent epiphyses (HP:0010577)1.81964708
146Rough bone trabeculation (HP:0100670)1.81614323
147Slender build (HP:0001533)1.81334267
148Agnosia (HP:0010524)1.81209234
149Prolonged neonatal jaundice (HP:0006579)1.81204302
150Gangrene (HP:0100758)1.80960633
151Vertebral compression fractures (HP:0002953)1.78854710
152Large hands (HP:0001176)1.78208707
153Granulocytopenia (HP:0001913)1.77095164
154Acrocyanosis (HP:0001063)1.75426012
155Pulmonary artery stenosis (HP:0004415)1.74663083
156Aortic dissection (HP:0002647)1.74183731
157Abnormality of the intrinsic pathway (HP:0010989)1.72421142
158Chronic otitis media (HP:0000389)1.72080889
159Thrombophlebitis (HP:0004418)1.71957541
160Aortic valve stenosis (HP:0001650)1.71744583
161Abnormality of transition element cation homeostasis (HP:0011030)1.71712886
162Cellulitis (HP:0100658)1.70877861
163Ureteral duplication (HP:0000073)1.70698964
164Eosinophilia (HP:0001880)1.70678797
165Reticulocytopenia (HP:0001896)1.70273708
166Chondrocalcinosis (HP:0000934)1.68809211
167Growth hormone excess (HP:0000845)1.68397929
168Abnormality of the umbilical cord (HP:0010881)1.68271605
169Purpura (HP:0000979)1.66966544
170Long foot (HP:0001833)1.65920334
171Abnormality of fatty-acid metabolism (HP:0004359)1.65571602
172Insulin-resistant diabetes mellitus (HP:0000831)1.63142669
173Abnormality of dicarboxylic acid metabolism (HP:0010995)1.60065586
174Dicarboxylic aciduria (HP:0003215)1.60065586
175Eczematoid dermatitis (HP:0000976)1.59437864
176Gastrointestinal dysmotility (HP:0002579)1.59055595
177Generalized amyotrophy (HP:0003700)1.58017548

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TIE14.52662733
2KDR3.36111884
3INSRR3.19935407
4MAP3K142.97017927
5PRPF4B2.91533539
6EIF2AK12.88188955
7TGFBR22.75732231
8BUB12.68388002
9WEE12.61418317
10TAOK22.59931575
11RIPK42.49139648
12CDC72.20954833
13TGFBR12.07369685
14TESK22.00384580
15TRPM71.92120191
16BLK1.84997632
17TRIB31.81163247
18NME21.80978602
19ERN11.72272207
20MATK1.68862068
21MAP2K31.65949452
22GRK71.57601214
23BRSK21.56809462
24PLK41.54300329
25NEK21.53890982
26TTN1.53865570
27STK101.52423952
28ZAK1.51227961
29FLT31.50816362
30TYK21.49338076
31DDR21.47930563
32MOS1.45852248
33MAP3K131.45317037
34FGFR41.45177197
35MAP4K11.42318108
36STK41.39598760
37PIM21.38873069
38SMG11.38386492
39BCKDK1.33917602
40ICK1.30208367
41JAK31.29379987
42ACVR1B1.24529793
43PKN21.23401051
44EEF2K1.21634003
45NEK91.15055645
46VRK11.13795509
47BMPR21.13533246
48LRRK21.13176251
49ZAP701.11298744
50ARAF1.10666484
51NEK11.10456417
52RPS6KA41.09521480
53MAP3K31.06926404
54CCNB11.05375016
55PIM11.05279487
56SIK31.04055425
57TESK11.03343074
58KIT1.02308132
59EIF2AK31.00627250
60TEC1.00490704
61TSSK61.00185800
62CDK120.99836852
63IRAK30.99595100
64STK240.99434664
65VRK20.99330551
66AURKB0.99324274
67CDK40.99016897
68MAP3K80.96570351
69FGR0.95800058
70MYLK0.93973802
71CSK0.92469351
72STK30.92347017
73SYK0.92334708
74TTK0.92226538
75PINK10.91461905
76TAOK30.88712687
77PDGFRA0.88535321
78MAP3K10.87740570
79CDC42BPA0.86921921
80BRSK10.83870351
81EPHB10.83711901
82EPHA30.82782269
83RIPK10.82574661
84TAOK10.81706586
85PLK10.81439968
86STK160.81180683
87ATR0.78007028
88JAK10.76514187
89TXK0.74304251
90LYN0.73930995
91PAK40.73605357
92MARK30.70893411
93TBK10.69841217
94CSF1R0.64918296
95CHUK0.64266127
96JAK20.63336521
97CDK70.63325111
98IRAK40.63044257
99MAP3K100.59931585
100MAP3K50.59749030
101EIF2AK20.59562476
102DYRK30.59012053
103SIK20.56866202
104RAF10.54011988
105MAPK110.53981118
106ILK0.53743408
107ABL20.53249197
108PDK20.52498964
109LCK0.50716259
110BTK0.50608699
111MKNK10.50580068
112NLK0.50004399
113BMX0.49793632
114CAMK1D0.49773788
115PBK0.49679030
116RPS6KB20.49485089
117HCK0.48227368
118PDK30.48116194
119PDK40.48116194
120MAPK120.48052308
121CDK60.47931425
122IKBKE0.47795554
123FGFR30.46706740
124AURKA0.46688175
125SRPK10.45832987
126BRAF0.45451208
127PLK30.44402372
128SIK10.43947632
129SCYL20.42232469
130MST1R0.42145347
131MAPKAPK30.42040295
132IKBKB0.41117179
133HIPK20.41049982
134MAP3K60.39749809
135RPS6KA50.38255346
136DAPK10.38212482
137MAP3K110.38137058
138MAPKAPK20.38024475
139PAK10.37622334
140PTK60.37575175
141ALK0.37330437
142CLK10.36731998
143MAPK40.36080074
144EPHA20.34919778
145PDPK10.33980709
146CHEK20.33847166
147IRAK20.30269859
148FES0.29877190
149MTOR0.27060222
150CHEK10.26610241

Predicted pathways (KEGG)

RankGene SetZ-score
1DNA replication_Homo sapiens_hsa030304.25559616
2Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008602.84779190
3Mismatch repair_Homo sapiens_hsa034302.48242388
4Base excision repair_Homo sapiens_hsa034102.43041906
5Asthma_Homo sapiens_hsa053102.42482465
6Allograft rejection_Homo sapiens_hsa053302.40864760
7Toll-like receptor signaling pathway_Homo sapiens_hsa046202.40844399
8Vitamin B6 metabolism_Homo sapiens_hsa007502.27434812
9Osteoclast differentiation_Homo sapiens_hsa043802.23113103
10Rheumatoid arthritis_Homo sapiens_hsa053232.19997044
11Lysosome_Homo sapiens_hsa041422.14950059
12Cell cycle_Homo sapiens_hsa041102.08385015
13Proteasome_Homo sapiens_hsa030502.03351401
14Graft-versus-host disease_Homo sapiens_hsa053322.01004700
15Autoimmune thyroid disease_Homo sapiens_hsa053201.96059582
16TNF signaling pathway_Homo sapiens_hsa046681.86268687
17Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.84468266
18Caffeine metabolism_Homo sapiens_hsa002321.82732513
19Homologous recombination_Homo sapiens_hsa034401.79495315
20Pertussis_Homo sapiens_hsa051331.75738277
21Glycosaminoglycan degradation_Homo sapiens_hsa005311.72766637
22Tuberculosis_Homo sapiens_hsa051521.71092076
23Pyrimidine metabolism_Homo sapiens_hsa002401.65902396
24NOD-like receptor signaling pathway_Homo sapiens_hsa046211.62967705
25One carbon pool by folate_Homo sapiens_hsa006701.61686024
26Nucleotide excision repair_Homo sapiens_hsa034201.55694606
27Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.50449833
28Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.47872372
29Type I diabetes mellitus_Homo sapiens_hsa049401.44697811
30B cell receptor signaling pathway_Homo sapiens_hsa046621.42670403
31Pentose phosphate pathway_Homo sapiens_hsa000301.40855224
32RNA transport_Homo sapiens_hsa030131.40181184
33Ribosome_Homo sapiens_hsa030101.37620702
34Salmonella infection_Homo sapiens_hsa051321.37115338
35Drug metabolism - other enzymes_Homo sapiens_hsa009831.35063033
36Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.33863595
37p53 signaling pathway_Homo sapiens_hsa041151.33836183
38Fatty acid degradation_Homo sapiens_hsa000711.24561077
39Small cell lung cancer_Homo sapiens_hsa052221.23976540
40Folate biosynthesis_Homo sapiens_hsa007901.23819433
41Prion diseases_Homo sapiens_hsa050201.22988589
42Shigellosis_Homo sapiens_hsa051311.22849320
43Bladder cancer_Homo sapiens_hsa052191.22801569
442-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.21747089
45Malaria_Homo sapiens_hsa051441.21128193
46Complement and coagulation cascades_Homo sapiens_hsa046101.20605280
47Systemic lupus erythematosus_Homo sapiens_hsa053221.20365414
48African trypanosomiasis_Homo sapiens_hsa051431.20351045
49Spliceosome_Homo sapiens_hsa030401.18367471
50Selenocompound metabolism_Homo sapiens_hsa004501.17606251
51RNA polymerase_Homo sapiens_hsa030201.15763706
52Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.15366744
53Phagosome_Homo sapiens_hsa041451.13609336
54ECM-receptor interaction_Homo sapiens_hsa045121.13257409
55Glutathione metabolism_Homo sapiens_hsa004801.08682196
56Herpes simplex infection_Homo sapiens_hsa051681.06945660
57Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.05176119
58Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.05047021
59Hepatitis C_Homo sapiens_hsa051601.02488449
60Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.01944477
61Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.01070185
62Carbon metabolism_Homo sapiens_hsa012001.00227330
63Antigen processing and presentation_Homo sapiens_hsa046120.98986444
64Apoptosis_Homo sapiens_hsa042100.96128920
65PPAR signaling pathway_Homo sapiens_hsa033200.94521770
66Fanconi anemia pathway_Homo sapiens_hsa034600.94394437
67Propanoate metabolism_Homo sapiens_hsa006400.93252332
68Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.92874277
69Purine metabolism_Homo sapiens_hsa002300.91845039
70Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.90160940
71Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.88999966
72Viral myocarditis_Homo sapiens_hsa054160.88604357
73Fructose and mannose metabolism_Homo sapiens_hsa000510.88031745
74Non-homologous end-joining_Homo sapiens_hsa034500.87967302
75Tryptophan metabolism_Homo sapiens_hsa003800.87897877
76Hematopoietic cell lineage_Homo sapiens_hsa046400.86979377
77Viral carcinogenesis_Homo sapiens_hsa052030.84866503
78Vitamin digestion and absorption_Homo sapiens_hsa049770.81680102
79Staphylococcus aureus infection_Homo sapiens_hsa051500.78900463
80Cysteine and methionine metabolism_Homo sapiens_hsa002700.78394737
81Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.78132485
82Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.76957176
83ABC transporters_Homo sapiens_hsa020100.75080136
84Pentose and glucuronate interconversions_Homo sapiens_hsa000400.74866572
85AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.73326076
86Renin-angiotensin system_Homo sapiens_hsa046140.73205561
87Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.72786184
88NF-kappa B signaling pathway_Homo sapiens_hsa040640.72769860
89Legionellosis_Homo sapiens_hsa051340.72453797
90Sulfur relay system_Homo sapiens_hsa041220.72060692
91Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.71375558
92Measles_Homo sapiens_hsa051620.70631000
93Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.70553853
94Lysine degradation_Homo sapiens_hsa003100.70544364
95Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.68644102
96Toxoplasmosis_Homo sapiens_hsa051450.67927180
97Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.66116418
98Epstein-Barr virus infection_Homo sapiens_hsa051690.65961913
99Focal adhesion_Homo sapiens_hsa045100.65814054
100Leishmaniasis_Homo sapiens_hsa051400.65531100
101Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.64374339
102Fatty acid metabolism_Homo sapiens_hsa012120.64204602
103RNA degradation_Homo sapiens_hsa030180.63149876
104Chemokine signaling pathway_Homo sapiens_hsa040620.62814733
105HTLV-I infection_Homo sapiens_hsa051660.62104339
106Primary bile acid biosynthesis_Homo sapiens_hsa001200.62016991
107beta-Alanine metabolism_Homo sapiens_hsa004100.61998575
108Biosynthesis of amino acids_Homo sapiens_hsa012300.60752218
109Galactose metabolism_Homo sapiens_hsa000520.60342790
110Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.59983924
111T cell receptor signaling pathway_Homo sapiens_hsa046600.59838258
112Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.59152823
113Hepatitis B_Homo sapiens_hsa051610.58224445
114Jak-STAT signaling pathway_Homo sapiens_hsa046300.57359050
115Amoebiasis_Homo sapiens_hsa051460.56732431
116Primary immunodeficiency_Homo sapiens_hsa053400.56509382
117Transcriptional misregulation in cancer_Homo sapiens_hsa052020.55790271
118Leukocyte transendothelial migration_Homo sapiens_hsa046700.54909715
119Insulin resistance_Homo sapiens_hsa049310.54602879
120Chronic myeloid leukemia_Homo sapiens_hsa052200.52092953
121Adipocytokine signaling pathway_Homo sapiens_hsa049200.51282359
122VEGF signaling pathway_Homo sapiens_hsa043700.49450290
123Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.49138350
124Intestinal immune network for IgA production_Homo sapiens_hsa046720.47998234
125HIF-1 signaling pathway_Homo sapiens_hsa040660.46475245
126Peroxisome_Homo sapiens_hsa041460.45467714
127Sphingolipid metabolism_Homo sapiens_hsa006000.42527122
128Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.42414331
129Acute myeloid leukemia_Homo sapiens_hsa052210.42235879
130Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.42035481
131Prolactin signaling pathway_Homo sapiens_hsa049170.40727337
132Influenza A_Homo sapiens_hsa051640.40485812
133Starch and sucrose metabolism_Homo sapiens_hsa005000.40424647
134Pancreatic cancer_Homo sapiens_hsa052120.40250807
135PI3K-Akt signaling pathway_Homo sapiens_hsa041510.39822043
136Other glycan degradation_Homo sapiens_hsa005110.39723784
137Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.39514130
138RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.39394313
139MicroRNAs in cancer_Homo sapiens_hsa052060.39037300
140Central carbon metabolism in cancer_Homo sapiens_hsa052300.36387853
141SNARE interactions in vesicular transport_Homo sapiens_hsa041300.30861686
142Non-small cell lung cancer_Homo sapiens_hsa052230.28892876
143Sphingolipid signaling pathway_Homo sapiens_hsa040710.26723288

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