SLC44A3

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1Golgi transport vesicle coating (GO:0048200)7.92578362
2COPI coating of Golgi vesicle (GO:0048205)7.92578362
3maintenance of protein localization in endoplasmic reticulum (GO:0035437)6.33840928
4protein retention in ER lumen (GO:0006621)5.95976042
5endocrine pancreas development (GO:0031018)5.50897654
6intestinal cholesterol absorption (GO:0030299)5.19155554
7COPII vesicle coating (GO:0048208)5.18287140
8exocrine pancreas development (GO:0031017)5.06008173
9retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)5.00127234
10cellular glucuronidation (GO:0052695)4.89778026
11glucuronate metabolic process (GO:0019585)4.68752541
12uronic acid metabolic process (GO:0006063)4.68752541
13glandular epithelial cell differentiation (GO:0002067)4.32456589
14signal peptide processing (GO:0006465)4.25243742
15peptide hormone processing (GO:0016486)4.22390423
16erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)4.18231892
17L-phenylalanine catabolic process (GO:0006559)4.18231892
18intestinal absorption (GO:0050892)4.16088759
19L-phenylalanine metabolic process (GO:0006558)3.95863571
20erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)3.95863571
21epoxygenase P450 pathway (GO:0019373)3.88301551
22auditory receptor cell differentiation (GO:0042491)3.81936186
23angiotensin maturation (GO:0002003)3.79791351
24purine ribonucleoside bisphosphate metabolic process (GO:0034035)3.72437219
253-phosphoadenosine 5-phosphosulfate metabolic process (GO:0050427)3.72437219
26desmosome organization (GO:0002934)3.68221964
27sulfur amino acid catabolic process (GO:0000098)3.68167347
28drug transmembrane transport (GO:0006855)3.67765779
29regulation of cell-cell adhesion mediated by cadherin (GO:2000047)3.66646072
30flavonoid metabolic process (GO:0009812)3.66207029
31ethanol oxidation (GO:0006069)3.56061491
32fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)3.53772058
33regulation of systemic arterial blood pressure by renin-angiotensin (GO:0003081)3.52933110
34regulation of type B pancreatic cell apoptotic process (GO:2000674)3.51066219
35activation of signaling protein activity involved in unfolded protein response (GO:0006987)3.51035222
36phenylpropanoid metabolic process (GO:0009698)3.44361081
37ER overload response (GO:0006983)3.44269238
38vesicle coating (GO:0006901)3.37828238
39regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway (GO:19022353.37701847
40bile acid and bile salt transport (GO:0015721)3.31944097
41intestinal epithelial cell development (GO:0060576)3.29922993
42positive regulation of nuclease activity (GO:0032075)3.26545331
43protein maturation by protein folding (GO:0022417)3.24956041
44sequestering of metal ion (GO:0051238)3.24649539
45UDP-N-acetylglucosamine metabolic process (GO:0006047)3.23666734
46bile acid metabolic process (GO:0008206)3.23491756
47digestion (GO:0007586)3.22419607
48positive regulation of glycolytic process (GO:0045821)3.22244922
49peptide catabolic process (GO:0043171)3.18235232
50ER-associated ubiquitin-dependent protein catabolic process (GO:0030433)3.15752945
51drug metabolic process (GO:0017144)3.13865939
52drug transport (GO:0015893)3.13804623
53columnar/cuboidal epithelial cell development (GO:0002066)3.11921098
54daunorubicin metabolic process (GO:0044597)3.11407150
55polyketide metabolic process (GO:0030638)3.11407150
56doxorubicin metabolic process (GO:0044598)3.11407150
57negative regulation of protein activation cascade (GO:2000258)3.10309789
58endoplasmic reticulum unfolded protein response (GO:0030968)3.10038472
59negative regulation of complement activation (GO:0045916)3.08765969
60aminoglycoside antibiotic metabolic process (GO:0030647)3.08255195
61ethanol metabolic process (GO:0006067)3.07994152
62cellular response to unfolded protein (GO:0034620)3.06258713
63transcytosis (GO:0045056)3.02855505
64tyrosine metabolic process (GO:0006570)3.02453346
65type B pancreatic cell development (GO:0003323)3.00959318
66positive regulation of insulin secretion (GO:0032024)3.00401589
67very-low-density lipoprotein particle assembly (GO:0034379)2.98969750
68primary alcohol catabolic process (GO:0034310)2.98401989
69ER-nucleus signaling pathway (GO:0006984)2.97104200
70regulation of protein activation cascade (GO:2000257)2.95964062
71cellular response to topologically incorrect protein (GO:0035967)2.95853982
72valine metabolic process (GO:0006573)2.95387004
73thyroid hormone generation (GO:0006590)2.95349961
74regulation of nuclease activity (GO:0032069)2.95167077
75aromatic amino acid family catabolic process (GO:0009074)2.94846540
76homocysteine metabolic process (GO:0050667)2.94702295
77urate metabolic process (GO:0046415)2.94684822
78regulation of glucokinase activity (GO:0033131)2.94511852
79regulation of hexokinase activity (GO:1903299)2.94511852
80regulation of ER to Golgi vesicle-mediated transport (GO:0060628)2.93198095
81regulation of vascular endothelial growth factor signaling pathway (GO:1900746)2.91702107
82maintenance of gastrointestinal epithelium (GO:0030277)2.89328732
83regulation of guanylate cyclase activity (GO:0031282)2.89264843
84excretion (GO:0007588)2.89213097
85sodium ion homeostasis (GO:0055078)2.85652563
86negative regulation of digestive system process (GO:0060457)2.83958017
87plasma lipoprotein particle assembly (GO:0034377)2.82180961
88regulation of complement activation (GO:0030449)2.82115721
89cysteine metabolic process (GO:0006534)2.81461882
90urea metabolic process (GO:0019627)2.80625093
91phospholipid efflux (GO:0033700)2.80438387
92urea cycle (GO:0000050)2.79729927
934-hydroxyproline metabolic process (GO:0019471)2.78809708
94glandular epithelial cell development (GO:0002068)2.77730192
95nucleoside bisphosphate metabolic process (GO:0033865)2.76886489
96purine nucleoside bisphosphate metabolic process (GO:0034032)2.76886489
97ribonucleoside bisphosphate metabolic process (GO:0033875)2.76886489
98bundle of His cell to Purkinje myocyte communication (GO:0086069)2.75454775
99response to endoplasmic reticulum stress (GO:0034976)2.75444672
100protein autoprocessing (GO:0016540)2.75324168
101protein N-linked glycosylation via asparagine (GO:0018279)2.74914616
102peptidyl-asparagine modification (GO:0018196)2.73382417
103renal system process involved in regulation of blood volume (GO:0001977)2.73063600
104fatty acid beta-oxidation (GO:0006635)2.72233984
105biotin metabolic process (GO:0006768)2.72174792
106thyroid hormone metabolic process (GO:0042403)2.71739494
107drug catabolic process (GO:0042737)2.70384880
108toxin metabolic process (GO:0009404)2.69995572
109primary alcohol metabolic process (GO:0034308)2.69826924
110insulin secretion (GO:0030073)2.67606377
111NADH metabolic process (GO:0006734)2.67574523
112glyoxylate metabolic process (GO:0046487)2.64685826
113renal system process involved in regulation of systemic arterial blood pressure (GO:0003071)2.64478142
114regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)2.64444255
115regulation of cholesterol homeostasis (GO:2000188)2.64430137
116peptidyl-glutamic acid carboxylation (GO:0017187)2.63529558
117protein carboxylation (GO:0018214)2.63529558
118hair cell differentiation (GO:0035315)2.63183002
119inner ear receptor cell differentiation (GO:0060113)2.63172891
120acylglycerol homeostasis (GO:0055090)2.63025660
121triglyceride homeostasis (GO:0070328)2.63025660
122GDP-mannose metabolic process (GO:0019673)2.62323296
123fatty acid oxidation (GO:0019395)2.61775913
124reverse cholesterol transport (GO:0043691)2.60507486
125intra-Golgi vesicle-mediated transport (GO:0006891)2.59506131
126hormone catabolic process (GO:0042447)2.59479389
127pyrimidine-containing compound transmembrane transport (GO:0072531)2.59241207
128short-chain fatty acid metabolic process (GO:0046459)2.57908915
129branched-chain amino acid catabolic process (GO:0009083)2.57340058
130multicellular organismal water homeostasis (GO:0050891)2.56985160
131positive regulation of peptide hormone secretion (GO:0090277)2.56913520
132positive regulation of glycoprotein metabolic process (GO:1903020)2.56885227
133regulation of systemic arterial blood pressure by hormone (GO:0001990)2.56738165
134regulation of systemic arterial blood pressure mediated by a chemical signal (GO:0003044)2.56738165
135endocrine process (GO:0050886)2.56738165
136lipid oxidation (GO:0034440)2.56115113
137digestive system process (GO:0022600)2.54612107
138protein N-linked glycosylation (GO:0006487)2.54358875
139fat-soluble vitamin biosynthetic process (GO:0042362)2.54242362
140positive regulation of glycoprotein biosynthetic process (GO:0010560)2.53773286
141positive regulation of fatty acid biosynthetic process (GO:0045723)2.53765662
142branched-chain amino acid metabolic process (GO:0009081)2.53438676
143regulation of bile acid biosynthetic process (GO:0070857)2.52932912
144regulation of cholesterol metabolic process (GO:0090181)2.52683297
145protein-lipid complex assembly (GO:0065005)2.52679180
146peptide metabolic process (GO:0006518)2.52222613
147surfactant homeostasis (GO:0043129)2.52162273
148regulation of cholesterol esterification (GO:0010872)2.51830352
149negative regulation of keratinocyte proliferation (GO:0010839)2.51382237
150phosphate ion transmembrane transport (GO:0035435)2.50765827
151high-density lipoprotein particle remodeling (GO:0034375)2.50198482
152nucleotide-sugar biosynthetic process (GO:0009226)2.48793960
153nitric oxide mediated signal transduction (GO:0007263)2.48534268
154fatty acid catabolic process (GO:0009062)2.48509914
155vitamin transmembrane transport (GO:0035461)2.48172165
156arginine metabolic process (GO:0006525)2.47906795
157O-glycan processing (GO:0016266)2.47734075
158ER to Golgi vesicle-mediated transport (GO:0006888)2.47390943
159calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules (GO:0016338)2.45990897
160actin filament depolymerization (GO:0030042)2.45682489
161regulation of insulin secretion (GO:0050796)2.45659416
162detection of chemical stimulus involved in sensory perception of bitter taste (GO:0001580)2.45422798
163positive regulation of peptide secretion (GO:0002793)2.45161300
164L-alpha-amino acid transmembrane transport (GO:1902475)2.45115252
165bile acid biosynthetic process (GO:0006699)2.44564574
166glycoside metabolic process (GO:0016137)2.44275584
167complement activation, classical pathway (GO:0006958)2.44095242
168glutamine family amino acid biosynthetic process (GO:0009084)2.42823612
169phenol-containing compound catabolic process (GO:0019336)2.42803893
170phospholipid homeostasis (GO:0055091)2.42424262
171vitamin transport (GO:0051180)2.42135859
172renal absorption (GO:0070293)2.41641957
173glutathione derivative metabolic process (GO:1901685)2.41417231
174glutathione derivative biosynthetic process (GO:1901687)2.41417231
175retinol metabolic process (GO:0042572)2.40803816
176xenobiotic catabolic process (GO:0042178)2.40539919
177regulation of heart rate by cardiac conduction (GO:0086091)2.39686458

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1ESR1_17901129_ChIP-ChIP_LIVER_Mouse5.57980639
2RXR_22158963_ChIP-Seq_LIVER_Mouse4.55368294
3FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse4.07443933
4PPARA_22158963_ChIP-Seq_LIVER_Mouse4.01453725
5LXR_22158963_ChIP-Seq_LIVER_Mouse4.00897264
6GATA1_22025678_ChIP-Seq_K562_Human3.50141407
7FOXO1_23066095_ChIP-Seq_LIVER_Mouse3.36586948
8* SOX2_27498859_Chip-Seq_STOMACH_Mouse3.09013777
9EGR1_23403033_ChIP-Seq_LIVER_Mouse3.08716431
10CEBPA_23403033_ChIP-Seq_LIVER_Mouse2.75048724
11PPARG_19300518_ChIP-PET_3T3-L1_Mouse2.69468137
12NR1I2_20693526_ChIP-Seq_LIVER_Mouse2.66951055
13ESR1_21235772_ChIP-Seq_MCF-7_Human2.52398135
14* GATA4_25053715_ChIP-Seq_YYC3_Human2.44043369
15* FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human2.34959963
16* STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse2.29543909
17FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human2.17921519
18SOX2_20726797_ChIP-Seq_SW620_Human2.07625597
19TP63_17297297_ChIP-ChIP_HaCaT_Human2.07559282
20CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.97394824
21STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.89831931
22ZNF217_24962896_ChIP-Seq_MCF-7_Human1.88711429
23ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.88328442
24HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.84252684
25TCF4_18268006_ChIP-ChIP_LS174T_Human1.79027011
26CLOCK_20551151_ChIP-Seq_293T_Human1.75851006
27AR_21915096_ChIP-Seq_LNCaP-1F5_Human1.69945303
28ESR2_21235772_ChIP-Seq_MCF-7_Human1.67221220
29TRIM28_21343339_ChIP-Seq_HEK293_Human1.65431472
30CDX2_20551321_ChIP-Seq_CACO-2_Human1.65069972
31* FOXA2_19822575_ChIP-Seq_HepG2_Human1.59544649
32* GATA6_25053715_ChIP-Seq_YYC3_Human1.57711431
33GATA3_24758297_ChIP-Seq_MCF-7_Human1.52030985
34TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.51138195
35FOXA1_25552417_ChIP-Seq_VCAP_Human1.44497261
36TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.43961893
37PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.41936415
38ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.41306802
39* PIAS1_25552417_ChIP-Seq_VCAP_Human1.36316486
40TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.35566285
41RARG_19884340_ChIP-ChIP_MEFs_Mouse1.26675175
42DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.23991962
43HIF1A_21447827_ChIP-Seq_MCF-7_Human1.23055016
44CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.21814948
45PPARD_23208498_ChIP-Seq_MDA-MB-231_Human1.21747209
46PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.20993389
47TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.19985569
48TCF7L2_21901280_ChIP-Seq_H4IIE_Rat1.18100233
49ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.17371144
50* PPAR_26484153_Chip-Seq_NCI-H1993_Human1.16553987
51PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.16522184
52* ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.14626841
53ESR1_20079471_ChIP-ChIP_T-47D_Human1.14444622
54KLF5_25053715_ChIP-Seq_YYC3_Human1.13982122
55FOXA1_26743006_Chip-Seq_LNCaP-abl_Human1.13672960
56FOXO3_23340844_ChIP-Seq_DLD1_Human1.13507420
57GATA2_21666600_ChIP-Seq_HMVEC_Human1.12479607
58* HNF4A_19822575_ChIP-Seq_HepG2_Human1.11006998
59MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.10786072
60FOXM1_26456572_ChIP-Seq_MCF-7_Human1.10651035
61BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.10600855
62GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.09570407
63ERG_20517297_ChIP-Seq_VCAP_Human1.08204906
64* TP53_18474530_ChIP-ChIP_U2OS_Human1.07195351
65SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.06089501
66PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.05428483
67AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.05283654
68* SALL4_18804426_ChIP-ChIP_XEN_Mouse1.03854671
69CDX2_19796622_ChIP-Seq_MESCs_Mouse1.01283258
70RUNX1_27514584_Chip-Seq_MCF-7_Human1.01222477
71AR_20517297_ChIP-Seq_VCAP_Human1.00964386
72IRF8_22096565_ChIP-ChIP_GC-B_Human0.98256446
73SOX2_18358816_ChIP-ChIP_MESCs_Mouse0.96419661
74NR3C1_21868756_ChIP-Seq_MCF10A_Human0.95287369
75* NRF2_20460467_ChIP-Seq_MEFs_Mouse0.95126276
76* NFE2L2_20460467_ChIP-Seq_MEFs_Mouse0.95126276
77CTNNB1_20460455_ChIP-Seq_HCT116_Human0.95109806
78TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.93098212
79AHR_22903824_ChIP-Seq_MCF-7_Human0.92086904
80* FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human0.91380041
81SMAD3_21741376_ChIP-Seq_HESCs_Human0.91272776
82* SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse0.90375213
83TCF4_22108803_ChIP-Seq_LS180_Human0.88268475
84TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse0.88000072
85HTT_18923047_ChIP-ChIP_STHdh_Human0.86486939
86CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.85547332
87BCAT_22108803_ChIP-Seq_LS180_Human0.85055733
88BMI1_19503595_ChIP-Seq_MEFsC_Mouse0.85010696
89SMAD4_21741376_ChIP-Seq_HESCs_Human0.83609958
90* AR_21909140_ChIP-Seq_LNCAP_Human0.83506354
91SMAD2_18955504_ChIP-ChIP_HaCaT_Human0.83427995
92SMAD3_18955504_ChIP-ChIP_HaCaT_Human0.83427995
93NANOG_18700969_ChIP-ChIP_MESCs_Mouse0.82797929
94STAT6_21828071_ChIP-Seq_BEAS2B_Human0.82641067
95* CJUN_26792858_Chip-Seq_BT549_Human0.80841137
96* STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse0.80833813
97TP53_16413492_ChIP-PET_HCT116_Human0.80530144
98* HNFA_21074721_ChIP-Seq_CACO-2_Human0.80501923
99MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse0.80326105
100CDX2_22108803_ChIP-Seq_LS180_Human0.79970260
101FOXA1_21572438_ChIP-Seq_LNCaP_Human0.79057240
102RXR_22108803_ChIP-Seq_LS180_Human0.78609850
103GATA3_20176728_ChIP-ChIP_TSCs_Mouse0.77978970
104ARNT_22903824_ChIP-Seq_MCF-7_Human0.77825515
105PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.77810657
106* TP63_23658742_ChIP-Seq_EP156T_Human0.77703062
107* PCGF4_22325352_ChIP-Seq_293T-Rex_Human0.76694837
108SOX9_24532713_ChIP-Seq_HFSC_Mouse0.76511745
109WT1_25993318_ChIP-Seq_PODOCYTE_Human0.75895561
110* CDX2_21074721_ChIP-Seq_CACO-2_Mouse0.75821540
111* SMAD3_21741376_ChIP-Seq_EPCs_Human0.75715133
112EP300_21415370_ChIP-Seq_HL-1_Mouse0.75433095
113NFIB_24661679_ChIP-Seq_LUNG_Mouse0.75112005
114* SMAD4_21799915_ChIP-Seq_A2780_Human0.74812358
115* EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse0.74555010
116P63_26484246_Chip-Seq_KERATINOCYTES_Human0.74446789
117CHD7_19251738_ChIP-ChIP_MESCs_Mouse0.73986669
118ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human0.73004010
119EBNA1_20929547_Chip-Seq_RAJI-cells_Human0.72778641
120PPARG_20176806_ChIP-Seq_3T3-L1_Mouse0.72491689
121RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse0.68287628
122ETV2_25802403_ChIP-Seq_MESCs_Mouse0.67998005
123RARA_24833708_ChIP-Seq_LIVER_Mouse0.67050143
124* KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human0.66691625
125RACK7_27058665_Chip-Seq_MCF-7_Human0.66337890
126EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human0.66300611
127* KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human0.65974282
128CEBPA_26348894_ChIP-Seq_LIVER_Mouse0.65401841
129PBX1_22567123_ChIP-ChIP_OVCAR3_Human0.64604061
130ZNF274_21170338_ChIP-Seq_K562_Hela0.64522792

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002139_abnormal_hepatobiliary_system4.37573008
2MP0005365_abnormal_bile_salt4.30660749
3MP0001666_abnormal_nutrient_absorption3.51646528
4MP0003283_abnormal_digestive_organ3.42650779
5MP0003195_calcinosis3.32653973
6MP0005220_abnormal_exocrine_pancreas3.14694804
7MP0005085_abnormal_gallbladder_physiolo3.09432673
8MP0004043_abnormal_pH_regulation3.06750421
9MP0004264_abnormal_extraembryonic_tissu2.93708261
10MP0005360_urolithiasis2.86641258
11MP0005083_abnormal_biliary_tract2.83096609
12MP0002138_abnormal_hepatobiliary_system2.70494919
13MP0010386_abnormal_urinary_bladder2.64892987
14MP0009780_abnormal_chondrocyte_physiolo2.60032369
15MP0000013_abnormal_adipose_tissue2.57137467
16MP0001944_abnormal_pancreas_morphology2.55538905
17MP0002693_abnormal_pancreas_physiology2.52034077
18MP0003183_abnormal_peptide_metabolism2.48044617
19MP0003252_abnormal_bile_duct2.46288283
20MP0001986_abnormal_taste_sensitivity2.45766551
21MP0008875_abnormal_xenobiotic_pharmacok2.41321730
22MP0002909_abnormal_adrenal_gland2.38644400
23MP0000678_abnormal_parathyroid_gland2.33063974
24MP0002877_abnormal_melanocyte_morpholog2.32939568
25MP0005084_abnormal_gallbladder_morpholo2.25360223
26MP0005379_endocrine/exocrine_gland_phen2.22209299
27MP0008004_abnormal_stomach_pH2.19445735
28MP0003868_abnormal_feces_composition2.18234186
29MP0000462_abnormal_digestive_system1.98918835
30MP0010352_gastrointestinal_tract_polyps1.96234245
31MP0010329_abnormal_lipoprotein_level1.93471490
32MP0009643_abnormal_urine_homeostasis1.89705872
33MP0010234_abnormal_vibrissa_follicle1.80272328
34MP0003300_gastrointestinal_ulcer1.77993406
35MP0005409_darkened_coat_color1.74023137
36MP0004782_abnormal_surfactant_physiolog1.71116588
37MP0002254_reproductive_system_inflammat1.71076541
38MP0002078_abnormal_glucose_homeostasis1.63199514
39MP0002928_abnormal_bile_duct1.62095041
40MP0002876_abnormal_thyroid_physiology1.58205065
41MP0000003_abnormal_adipose_tissue1.53481684
42MP0010678_abnormal_skin_adnexa1.52488252
43MP0002118_abnormal_lipid_homeostasis1.51460479
44MP0001765_abnormal_ion_homeostasis1.46306475
45MP0000516_abnormal_urinary_system1.46305055
46MP0005367_renal/urinary_system_phenotyp1.46305055
47MP0001756_abnormal_urination1.44856910
48MP0004019_abnormal_vitamin_homeostasis1.43921110
49MP0003806_abnormal_nucleotide_metabolis1.40601347
50MP0002837_dystrophic_cardiac_calcinosis1.40128240
51MP0002796_impaired_skin_barrier1.39882423
52MP0005408_hypopigmentation1.38624738
53MP0005636_abnormal_mineral_homeostasis1.37292860
54MP0000538_abnormal_urinary_bladder1.33755264
55MP0003879_abnormal_hair_cell1.30603503
56MP0003941_abnormal_skin_development1.26990975
57MP0005645_abnormal_hypothalamus_physiol1.26821673
58MP0005332_abnormal_amino_acid1.26073213
59MP0001664_abnormal_digestion1.25159561
60MP0000613_abnormal_salivary_gland1.22426504
61MP0004270_analgesia1.18166264
62MP0001485_abnormal_pinna_reflex1.17504072
63MP0000609_abnormal_liver_physiology1.14836420
64MP0003953_abnormal_hormone_level1.14773684
65MP0000681_abnormal_thyroid_gland1.14350847
66MP0005058_abnormal_lysosome_morphology1.12518054
67MP0003191_abnormal_cellular_cholesterol1.11993952
68MP0002896_abnormal_bone_mineralization1.09376983
69MP0002822_catalepsy1.04121582
70MP0004147_increased_porphyrin_level1.02642256
71MP0001764_abnormal_homeostasis0.98882848
72MP0000566_synostosis0.98537967
73MP0000477_abnormal_intestine_morphology0.96843488
74MP0009379_abnormal_foot_pigmentation0.91309243
75MP0002168_other_aberrant_phenotype0.90972097
76MP0002098_abnormal_vibrissa_morphology0.90406948
77MP0003878_abnormal_ear_physiology0.88867179
78MP0005377_hearing/vestibular/ear_phenot0.88867179
79MP0003959_abnormal_lean_body0.88354374
80MP0009840_abnormal_foam_cell0.84220424
81MP0005448_abnormal_energy_balance0.84124637
82MP0005166_decreased_susceptibility_to0.83848575
83MP0002132_abnormal_respiratory_system0.83041622
84MP0002163_abnormal_gland_morphology0.82736495
85MP0001270_distended_abdomen0.81514968
86MP0005319_abnormal_enzyme/_coenzyme0.78862938
87MP0005670_abnormal_white_adipose0.77038192
88MP0005501_abnormal_skin_physiology0.75596704
89MP0005375_adipose_tissue_phenotype0.75447222
90MP0000467_abnormal_esophagus_morphology0.73332861
91MP0006072_abnormal_retinal_apoptosis0.73269941
92MP0005310_abnormal_salivary_gland0.72976939
93MP0003186_abnormal_redox_activity0.71430645
94MP0006054_spinal_hemorrhage0.71092443
95MP0005334_abnormal_fat_pad0.69957874
96MP0009642_abnormal_blood_homeostasis0.69360450
97MP0005257_abnormal_intraocular_pressure0.69334210
98MP0005248_abnormal_Harderian_gland0.68011855
99MP0003045_fibrosis0.67538734
100MP0002295_abnormal_pulmonary_circulatio0.66031777
101MP0000537_abnormal_urethra_morphology0.65599161
102MP0004484_altered_response_of0.63605867
103MP0001849_ear_inflammation0.63342675
104MP0000230_abnormal_systemic_arterial0.63167283
105MP0003866_abnormal_defecation0.63013434
106MP0005646_abnormal_pituitary_gland0.62924975
107MP0005381_digestive/alimentary_phenotyp0.62447584
108MP0009384_cardiac_valve_regurgitation0.61858538
109MP0003011_delayed_dark_adaptation0.61801414
110MP0005535_abnormal_body_temperature0.61792310
111MP0002938_white_spotting0.60212668
112MP0008961_abnormal_basal_metabolism0.59964753
113MP0004272_abnormal_basement_membrane0.58543393
114MP0000639_abnormal_adrenal_gland0.58259674
115MP0002277_abnormal_respiratory_mucosa0.57743633
116MP0005410_abnormal_fertilization0.56714615
117MP0000377_abnormal_hair_follicle0.56680990
118MP0005584_abnormal_enzyme/coenzyme_acti0.56447055
119MP0002136_abnormal_kidney_physiology0.55070225
120MP0005666_abnormal_adipose_tissue0.53794443
121MP0000383_abnormal_hair_follicle0.53142563
122MP0010030_abnormal_orbit_morphology0.52880044
123MP0008872_abnormal_physiological_respon0.52110060
124MP0001188_hyperpigmentation0.51848892
125MP0003315_abnormal_perineum_morphology0.51574208
126MP0003122_maternal_imprinting0.51433036
127MP0000598_abnormal_liver_morphology0.50958459
128MP0000470_abnormal_stomach_morphology0.50922525
129MP0005395_other_phenotype0.50711378
130MP0010155_abnormal_intestine_physiology0.50396814
131MP0000534_abnormal_ureter_morphology0.49229920
132MP0001661_extended_life_span0.48991374
133MP0003119_abnormal_digestive_system0.47492325
134MP0004885_abnormal_endolymph0.47289666
135MP0002234_abnormal_pharynx_morphology0.46296267
136MP0001502_abnormal_circadian_rhythm0.45876452

Predicted human phenotypes

RankGene SetZ-score
1Hypoglycemic coma (HP:0001325)5.84527767
2Hypoglycemic seizures (HP:0002173)5.80733419
3Hyperinsulinemic hypoglycemia (HP:0000825)5.53932574
4Symptomatic seizures (HP:0011145)5.02644026
5Ketoacidosis (HP:0001993)4.60593879
6Abnormality of aromatic amino acid family metabolism (HP:0004338)4.26060258
7Hyperglycemia (HP:0003074)4.24774730
8Hyperactive renin-angiotensin system (HP:0000841)4.21084186
9Insulin-resistant diabetes mellitus (HP:0000831)3.86442863
10Conjugated hyperbilirubinemia (HP:0002908)3.85946316
11Metabolic alkalosis (HP:0200114)3.82260054
12Late onset (HP:0003584)3.78634342
13Gout (HP:0001997)3.78173029
14Abnormality of the intrinsic pathway (HP:0010989)3.72083407
15Decreased circulating renin level (HP:0003351)3.63884515
16Elevated circulating parathyroid hormone (PTH) level (HP:0003165)3.61820193
17Abnormal pancreas size (HP:0012094)3.52720369
18Abnormality of the pancreatic islet cells (HP:0006476)3.52417066
19Abnormality of endocrine pancreas physiology (HP:0012093)3.52417066
20Hypobetalipoproteinemia (HP:0003563)3.50670371
21Ketosis (HP:0001946)3.39749797
22Malnutrition (HP:0004395)3.26808544
23Abnormality of chloride homeostasis (HP:0011422)3.26493666
24Mucopolysacchariduria (HP:0008155)3.21059289
25Urinary glycosaminoglycan excretion (HP:0003541)3.21059289
26Intrahepatic cholestasis (HP:0001406)3.19504314
27Proximal tubulopathy (HP:0000114)3.14184995
28Hypolipoproteinemia (HP:0010981)3.13693485
29Abnormality of vitamin metabolism (HP:0100508)3.11760203
30Pancreatic islet-cell hyperplasia (HP:0004510)3.08238751
31Abnormality of polysaccharide metabolism (HP:0011012)3.01145299
32Abnormality of glycosaminoglycan metabolism (HP:0004371)3.01145299
33Abnormality of mucopolysaccharide metabolism (HP:0011020)3.01145299
34Focal segmental glomerulosclerosis (HP:0000097)2.99493424
35Generalized aminoaciduria (HP:0002909)2.94490626
36Abdominal distention (HP:0003270)2.94260262
37Insulin resistance (HP:0000855)2.83457179
38Abnormality of renin-angiotensin system (HP:0000847)2.80785098
39Exocrine pancreatic insufficiency (HP:0001738)2.80194346
40Right ventricular cardiomyopathy (HP:0011663)2.79410355
41Hypoalphalipoproteinemia (HP:0003233)2.77473385
42Abnormality of vitamin B metabolism (HP:0004340)2.76389291
43Large for gestational age (HP:0001520)2.75423499
44Abnormality of calcium-phosphate metabolism (HP:0100530)2.72255116
45Flat acetabular roof (HP:0003180)2.72103848
46Fat malabsorption (HP:0002630)2.69952221
47Hypokalemia (HP:0002900)2.68669643
48Abnormality of the common coagulation pathway (HP:0010990)2.67752847
49Dysostosis multiplex (HP:0000943)2.67186313
50Increased circulating renin level (HP:0000848)2.64308496
51Abnormality of purine metabolism (HP:0004352)2.62725873
52Chronic bronchitis (HP:0004469)2.61113602
53Hyperphosphatemia (HP:0002905)2.60594972
54Hydroxyprolinuria (HP:0003080)2.59604692
55Abnormality of proline metabolism (HP:0010907)2.59604692
56Hyperkalemia (HP:0002153)2.58040945
57Unilateral renal agenesis (HP:0000122)2.57564204
58Osteomalacia (HP:0002749)2.56071006
59Abnormality of monocarboxylic acid metabolism (HP:0010996)2.54420159
60Hyperaldosteronism (HP:0000859)2.54129609
61Prolonged partial thromboplastin time (HP:0003645)2.52445539
62Glomerulosclerosis (HP:0000096)2.51860438
63Vacuolated lymphocytes (HP:0001922)2.50551774
64Cardiovascular calcification (HP:0011915)2.49179662
65Hyperglycinuria (HP:0003108)2.48961476
66Glomerulonephritis (HP:0000099)2.47539583
67Abnormal tarsal ossification (HP:0008369)2.46881275
68Retinal atrophy (HP:0001105)2.43595692
69Abnormality of the level of lipoprotein cholesterol (HP:0010979)2.40174852
70Hypokalemic alkalosis (HP:0001949)2.39689435
71Glycosuria (HP:0003076)2.38382145
72Abnormality of urine glucose concentration (HP:0011016)2.38382145
73Congenital sensorineural hearing impairment (HP:0008527)2.38031018
74Complement deficiency (HP:0004431)2.37205209
75Renal cortical cysts (HP:0000803)2.34514645
76Hypotension (HP:0002615)2.33825913
77Abnormality of the vitamin B12 metabolism (HP:0004341)2.32093642
78Renal salt wasting (HP:0000127)2.30841910
79Nephritis (HP:0000123)2.30780011
80Delayed CNS myelination (HP:0002188)2.29580588
81Abnormality of potassium homeostasis (HP:0011042)2.28212905
82Xanthomatosis (HP:0000991)2.27588532
83Pigmentary retinal degeneration (HP:0001146)2.27233327
84Hyperparathyroidism (HP:0000843)2.20813240
85Abnormality of the renal cortex (HP:0011035)2.20276610
86Abnormality of long-chain fatty-acid metabolism (HP:0010964)2.19598943
87Systemic lupus erythematosus (HP:0002725)2.16883086
88Rickets (HP:0002748)2.16370087
89Hyponatremia (HP:0002902)2.14906028
90Enlarged kidneys (HP:0000105)2.14859019
91Widely patent fontanelles and sutures (HP:0004492)2.13657067
92Abnormal urine phosphate concentration (HP:0012599)2.13169142
93Alkalosis (HP:0001948)2.12981821
94Hypothermia (HP:0002045)2.12746989
95Abnormality of carpal bone ossification (HP:0006257)2.10842104
96Esophageal varix (HP:0002040)2.10083973
97Tachypnea (HP:0002789)2.07383978
98Pancreatitis (HP:0001733)2.06903980
99Respiratory insufficiency due to defective ciliary clearance (HP:0200073)2.04802671
100Congenital malformation of the right heart (HP:0011723)2.02260277
101Double outlet right ventricle (HP:0001719)2.02260277
102Protuberant abdomen (HP:0001538)2.01638655
103Abnormality of fatty-acid metabolism (HP:0004359)1.99343251
104Popliteal pterygium (HP:0009756)1.98989509
105Abnormal biliary tract morphology (HP:0012440)1.98338163
106Deep venous thrombosis (HP:0002625)1.97498031
107Hyperammonemia (HP:0001987)1.97289594
108Hyperglycinemia (HP:0002154)1.96253100
109Growth hormone excess (HP:0000845)1.96147613
110Metabolic acidosis (HP:0001942)1.95639077
111Increased purine levels (HP:0004368)1.90261476
112Hyperuricemia (HP:0002149)1.90261476
113Dicarboxylic aciduria (HP:0003215)1.90125542
114Abnormality of dicarboxylic acid metabolism (HP:0010995)1.90125542
115Goiter (HP:0000853)1.89824962
116Ileus (HP:0002595)1.89666838
117Nuclear cataract (HP:0100018)1.88334969
118Abnormality of magnesium homeostasis (HP:0004921)1.88286878
119Abnormality of serine family amino acid metabolism (HP:0010894)1.87510972
120Abnormality of glycine metabolism (HP:0010895)1.87510972
121Limb hypertonia (HP:0002509)1.87480460
122Vascular calcification (HP:0004934)1.87131683
123Tubulointerstitial fibrosis (HP:0005576)1.86525354
124Steatorrhea (HP:0002570)1.85360678
125Cystic liver disease (HP:0006706)1.85177837
126Sensorimotor neuropathy (HP:0007141)1.84929121
127Micronodular cirrhosis (HP:0001413)1.84835001
128Abnormality of aspartate family amino acid metabolism (HP:0010899)1.84491169
129Abnormality of nucleobase metabolism (HP:0010932)1.82173283
130Subcapsular cataract (HP:0000523)1.81996202
131Amelogenesis imperfecta (HP:0000705)1.80483108
132Abnormality of permanent molar morphology (HP:0011071)1.79621030
133Abnormality of the dental root (HP:0006486)1.79621030
134Taurodontia (HP:0000679)1.79621030
135Abnormality of complement system (HP:0005339)1.79392440
136Progressive neurologic deterioration (HP:0002344)1.79075164
137Renal tubular acidosis (HP:0001947)1.78809003
138Adrenal overactivity (HP:0002717)1.78190571
139Abnormality of sodium homeostasis (HP:0010931)1.77139708
140Facial shape deformation (HP:0011334)1.77006822
141Potter facies (HP:0002009)1.77006822
142Syncope (HP:0001279)1.76805721
143Abnormality of renal excretion (HP:0011036)1.76713700
144Hyperphosphaturia (HP:0003109)1.76518228
145Aplasia/hypoplasia of the uterus (HP:0008684)1.73806093
146Abnormality of glutamine family amino acid metabolism (HP:0010902)1.73636555
147Dehydration (HP:0001944)1.73582034
148Acute hepatic failure (HP:0006554)1.71921606
149Interstitial pulmonary disease (HP:0006530)1.71329510

Predicted kinase interactions (KEA)

RankGene SetZ-score
1INSRR5.39932439
2MAPK154.25363080
3FRK3.97818873
4PASK3.08227706
5MST1R3.03532591
6TAOK32.87997725
7MAP3K22.72756806
8ERN12.70339686
9ACVR1B2.61792787
10BCKDK2.60357422
11EPHA22.52325618
12OXSR12.50678205
13MAP3K122.39783089
14CASK2.39215120
15SIK12.39048248
16WNK42.14877631
17IRAK32.10041221
18MAP2K22.02650070
19LMTK22.00188810
20WNK31.97977495
21AKT31.96859617
22MET1.81690803
23PIK3CG1.81682748
24LATS11.80548609
25HIPK21.80409791
26ERBB31.80058149
27PRKD31.78144668
28PTK61.73983917
29EPHA31.56812906
30STK241.44831217
31FGFR21.37568778
32MAP3K31.32621938
33FGFR41.32296461
34FLT31.32288750
35FER1.30409814
36NUAK11.27446501
37PTK21.23198780
38TRIB31.21491781
39STK38L1.18897391
40TNIK1.15928510
41TAOK11.15802127
42EPHA41.14005409
43IRAK11.08760530
44TRIM281.05361123
45MST41.04885843
46PBK1.03112944
47PAK40.98601118
48MAP3K10.94463275
49MAP2K10.90859266
50STK30.86476523
51EIF2AK30.81859166
52BMPR1B0.81132196
53MAPKAPK30.79717511
54PRKG20.78054161
55DYRK1B0.77314801
56PAK30.76631640
57RIPK10.76074948
58NLK0.75462165
59EPHB10.74282601
60SGK20.72442333
61BMPR20.71503106
62ERBB20.68782997
63PDGFRA0.68770743
64NME10.67486894
65PHKG20.67185216
66PHKG10.67185216
67PIK3CA0.65919092
68ICK0.64776557
69TESK10.61950063
70STK380.61898387
71PRKAA10.61140029
72PRKCE0.60931150
73PRKCH0.59124823
74CAMK1D0.58665942
75PRKCI0.58640203
76CHUK0.57904250
77TRPM70.57877713
78SGK30.57681891
79PINK10.56162826
80TEC0.54218911
81CSNK1G10.53781039
82CDC42BPA0.53726182
83GSK3A0.52164871
84BRAF0.51276082
85PRKAA20.50810014
86RPS6KA20.49772085
87EPHB20.49404630
88BRSK20.49403956
89MINK10.49291402
90SGK2230.49030517
91SGK4940.49030517
92MUSK0.48708917
93CAMKK20.48522715
94LRRK20.48063452
95FGFR10.47238936
96ROCK10.46837352
97SIK30.46378745
98CAMK2G0.45751861
99ERBB40.44517057
100JAK20.43905796
101MAP4K20.43437116
102DDR20.42654048
103IRAK20.40592975
104ZAP700.39602651
105CSNK1A1L0.39373765
106IGF1R0.39195794
107PDPK10.37307443
108PRKD20.37278358
109ROCK20.37235154
110FGFR30.36010738
111CAMK2D0.35760972
112GRK10.34995202
113SRC0.34453911
114YES10.34308596
115RPS6KB20.33716649
116SCYL20.32838995
117CSK0.32782894
118PRKCZ0.32583379
119ITK0.31782558
120NTRK10.31741295
121EIF2AK10.31512765
122PRKACG0.31133024
123CSNK1A10.30722640
124STK390.30541226
125PDGFRB0.30387404
126BCR0.30094508
127DAPK20.29868229
128CSNK1G30.29355337
129MAP2K60.29204877
130NTRK30.28482940
131NEK90.28425984
132PRKCA0.27942375
133AKT20.26564964
134CAMK2B0.26458539
135MAP3K70.25462831
136JAK10.25401771
137ZAK0.25121454
138TIE10.24574890
139MTOR0.24440184
140MYLK0.23994160
141MARK30.23325109
142LATS20.23031098

Predicted pathways (KEGG)

RankGene SetZ-score
1Maturity onset diabetes of the young_Homo sapiens_hsa049506.76540356
2Sulfur metabolism_Homo sapiens_hsa009204.48958017
3Protein export_Homo sapiens_hsa030603.64803784
4Cyanoamino acid metabolism_Homo sapiens_hsa004602.53380286
5Fat digestion and absorption_Homo sapiens_hsa049752.41035867
6Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.30640619
7Protein processing in endoplasmic reticulum_Homo sapiens_hsa041412.24503818
8Tryptophan metabolism_Homo sapiens_hsa003802.03530688
9Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.99520429
10Fatty acid degradation_Homo sapiens_hsa000711.98577517
11Folate biosynthesis_Homo sapiens_hsa007901.77254921
12Selenocompound metabolism_Homo sapiens_hsa004501.73134047
13Pancreatic secretion_Homo sapiens_hsa049721.70938635
14Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.68224781
15Primary bile acid biosynthesis_Homo sapiens_hsa001201.60213575
16Pentose and glucuronate interconversions_Homo sapiens_hsa000401.59813746
17Histidine metabolism_Homo sapiens_hsa003401.57828183
18Butanoate metabolism_Homo sapiens_hsa006501.53252176
19Insulin secretion_Homo sapiens_hsa049111.51675208
20Other glycan degradation_Homo sapiens_hsa005111.49661746
21Propanoate metabolism_Homo sapiens_hsa006401.43040357
22Carbohydrate digestion and absorption_Homo sapiens_hsa049731.42958280
23ABC transporters_Homo sapiens_hsa020101.42897365
24Vibrio cholerae infection_Homo sapiens_hsa051101.42206492
25alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.41895738
26Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.33278174
27Linoleic acid metabolism_Homo sapiens_hsa005911.32666608
28Starch and sucrose metabolism_Homo sapiens_hsa005001.31041854
29Peroxisome_Homo sapiens_hsa041461.30413576
302-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.28045379
31Glycerolipid metabolism_Homo sapiens_hsa005611.25210350
32Fatty acid metabolism_Homo sapiens_hsa012121.24049384
33Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.21348848
34Vitamin B6 metabolism_Homo sapiens_hsa007501.19891828
35Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.19752851
36Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.19559490
37Tyrosine metabolism_Homo sapiens_hsa003501.17608845
38N-Glycan biosynthesis_Homo sapiens_hsa005101.17297291
39Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.17114970
40Protein digestion and absorption_Homo sapiens_hsa049741.16681399
41Glycosaminoglycan degradation_Homo sapiens_hsa005311.14958753
42Chemical carcinogenesis_Homo sapiens_hsa052041.13310015
43PPAR signaling pathway_Homo sapiens_hsa033201.05079133
44Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.02193220
45Galactose metabolism_Homo sapiens_hsa000521.02051373
46Phenylalanine metabolism_Homo sapiens_hsa003601.01874039
47Nitrogen metabolism_Homo sapiens_hsa009101.00204181
48Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.99028611
49beta-Alanine metabolism_Homo sapiens_hsa004100.98887739
50Vitamin digestion and absorption_Homo sapiens_hsa049770.98590912
51Lysosome_Homo sapiens_hsa041420.98237523
52Regulation of autophagy_Homo sapiens_hsa041400.92910394
53Mineral absorption_Homo sapiens_hsa049780.91289989
54Complement and coagulation cascades_Homo sapiens_hsa046100.86739872
55Drug metabolism - other enzymes_Homo sapiens_hsa009830.85804808
56Steroid hormone biosynthesis_Homo sapiens_hsa001400.84945408
57Fructose and mannose metabolism_Homo sapiens_hsa000510.84123818
58Tight junction_Homo sapiens_hsa045300.84085525
59Type II diabetes mellitus_Homo sapiens_hsa049300.82367491
60Arachidonic acid metabolism_Homo sapiens_hsa005900.81279939
61Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.81196735
62Bile secretion_Homo sapiens_hsa049760.80907789
63Arginine biosynthesis_Homo sapiens_hsa002200.80284159
64Renin-angiotensin system_Homo sapiens_hsa046140.79472787
65Thyroid hormone synthesis_Homo sapiens_hsa049180.78713194
66Insulin resistance_Homo sapiens_hsa049310.74072383
67Circadian rhythm_Homo sapiens_hsa047100.73300610
68Fatty acid elongation_Homo sapiens_hsa000620.72618507
69Retinol metabolism_Homo sapiens_hsa008300.71575288
70Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.71372553
71Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.69523812
72Pyruvate metabolism_Homo sapiens_hsa006200.64095445
73Arginine and proline metabolism_Homo sapiens_hsa003300.60647000
74Glycerophospholipid metabolism_Homo sapiens_hsa005640.55363780
75Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.54340593
76Taste transduction_Homo sapiens_hsa047420.54070173
77Lysine degradation_Homo sapiens_hsa003100.52150643
78Caffeine metabolism_Homo sapiens_hsa002320.51858007
79Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.47794134
80Fatty acid biosynthesis_Homo sapiens_hsa000610.47543071
81Glutathione metabolism_Homo sapiens_hsa004800.46582156
82Sulfur relay system_Homo sapiens_hsa041220.46545415
83Metabolic pathways_Homo sapiens_hsa011000.45822052
84Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.44927788
85Glucagon signaling pathway_Homo sapiens_hsa049220.43784876
86Sphingolipid metabolism_Homo sapiens_hsa006000.43091613
87Type I diabetes mellitus_Homo sapiens_hsa049400.42603411
88Biosynthesis of amino acids_Homo sapiens_hsa012300.42400005
89Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.42058481
90Adherens junction_Homo sapiens_hsa045200.40403424
91Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.37792667
92Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.35387863
93Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.34539415
94Cocaine addiction_Homo sapiens_hsa050300.34479498
95Ether lipid metabolism_Homo sapiens_hsa005650.33569740
96Collecting duct acid secretion_Homo sapiens_hsa049660.32863459
97Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.32857902
98Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.32235879
99SNARE interactions in vesicular transport_Homo sapiens_hsa041300.31162750
100Carbon metabolism_Homo sapiens_hsa012000.30575463
101Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.29487064
102Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.29407109
103Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.29119553
104Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.26869439
105Bladder cancer_Homo sapiens_hsa052190.25806566
106Prion diseases_Homo sapiens_hsa050200.25786316
107Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.25670386
108Prolactin signaling pathway_Homo sapiens_hsa049170.23787774
109Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.22855380
110Renin secretion_Homo sapiens_hsa049240.22193141
111Ovarian steroidogenesis_Homo sapiens_hsa049130.22016594
112Steroid biosynthesis_Homo sapiens_hsa001000.21829821
113ECM-receptor interaction_Homo sapiens_hsa045120.21514708
114Cysteine and methionine metabolism_Homo sapiens_hsa002700.21058025
115Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.20938654
116Amphetamine addiction_Homo sapiens_hsa050310.17963200

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