SLC44A4

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene may be a sodium-dependent transmembrane transport protein involved in the uptake of choline by cholinergic neurons. Defects in this gene can cause sialidosis, a lysosomal storage disease. Three transcript variants encoding different isoforms have been found for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)9.89737768
2epithelial cilium movement (GO:0003351)9.18470831
3primary alcohol catabolic process (GO:0034310)7.20542843
4bile acid and bile salt transport (GO:0015721)6.93346615
5axoneme assembly (GO:0035082)6.93201577
6ethanol metabolic process (GO:0006067)6.61699727
7maintenance of gastrointestinal epithelium (GO:0030277)6.56799808
8left/right pattern formation (GO:0060972)6.21576911
9intestinal epithelial cell development (GO:0060576)5.76820260
10ethanol oxidation (GO:0006069)5.70509975
11sulfate transmembrane transport (GO:1902358)5.67905494
12sulfur amino acid catabolic process (GO:0000098)5.60254675
13bundle of His cell to Purkinje myocyte communication (GO:0086069)5.56261197
14diterpenoid biosynthetic process (GO:0016102)5.53041162
15UDP-N-acetylglucosamine metabolic process (GO:0006047)5.50079624
16vitamin transmembrane transport (GO:0035461)5.37204910
17regulation of cilium movement (GO:0003352)5.26075748
18epithelial structure maintenance (GO:0010669)5.12496568
19calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules (GO:0016338)4.99665998
20sulfur compound transport (GO:0072348)4.88826935
213-phosphoadenosine 5-phosphosulfate metabolic process (GO:0050427)4.78342861
22purine ribonucleoside bisphosphate metabolic process (GO:0034035)4.78342861
23drug transmembrane transport (GO:0006855)4.74857941
24negative regulation of epidermal growth factor-activated receptor activity (GO:0007175)4.69573140
25left/right axis specification (GO:0070986)4.69301108
26sulfate transport (GO:0008272)4.66554372
27pyrimidine-containing compound transmembrane transport (GO:0072531)4.65795265
28intestinal absorption (GO:0050892)4.62908444
29sperm capacitation (GO:0048240)4.62265270
30positive regulation of glycoprotein biosynthetic process (GO:0010560)4.59646958
31O-glycan processing (GO:0016266)4.57697378
32ventricular system development (GO:0021591)4.37355700
33desmosome organization (GO:0002934)4.37051193
34one-carbon compound transport (GO:0019755)4.32913903
35actin filament depolymerization (GO:0030042)4.32487251
36regulation of protein glycosylation (GO:0060049)4.32231576
37positive regulation of glycoprotein metabolic process (GO:1903020)4.30227614
38drug transport (GO:0015893)4.29094513
39regulation of guanylate cyclase activity (GO:0031282)4.26080244
40microtubule bundle formation (GO:0001578)4.24684984
41flavonoid metabolic process (GO:0009812)4.18725393
42lung epithelium development (GO:0060428)4.11622301
43negative regulation of protein tyrosine kinase activity (GO:0061099)4.10466786
44negative regulation of toll-like receptor 4 signaling pathway (GO:0034144)4.05452516
45oligosaccharide biosynthetic process (GO:0009312)4.05086906
46cytidine deamination (GO:0009972)4.03678889
47cytidine metabolic process (GO:0046087)4.03678889
48cytidine catabolic process (GO:0006216)4.03678889
49renal absorption (GO:0070293)4.00678767
50phospholipase C-activating dopamine receptor signaling pathway (GO:0060158)3.96265892
51primary alcohol metabolic process (GO:0034308)3.88585885
52modified amino acid transport (GO:0072337)3.86922051
53negative regulation of keratinocyte proliferation (GO:0010839)3.85419242
54drug catabolic process (GO:0042737)3.84242609
55regulation of viral release from host cell (GO:1902186)3.79934807
56regulation of bile acid biosynthetic process (GO:0070857)3.79281030
57hemidesmosome assembly (GO:0031581)3.79109702
58cGMP-mediated signaling (GO:0019934)3.78829702
59negative regulation of humoral immune response (GO:0002921)3.78188299
60intraciliary transport (GO:0042073)3.71605800
61response to xenobiotic stimulus (GO:0009410)3.69831208
62multicellular organismal water homeostasis (GO:0050891)3.69629116
63terpenoid biosynthetic process (GO:0016114)3.69382636
64establishment of apical/basal cell polarity (GO:0035089)3.69262104
65transcytosis (GO:0045056)3.68355072
66cilium organization (GO:0044782)3.63611802
67tolerance induction (GO:0002507)3.63386482
68purine nucleoside bisphosphate biosynthetic process (GO:0034033)3.61715988
69ribonucleoside bisphosphate biosynthetic process (GO:0034030)3.61715988
70nucleoside bisphosphate biosynthetic process (GO:0033866)3.61715988
71glomerular epithelial cell development (GO:0072310)3.59392482
72epithelial cell-cell adhesion (GO:0090136)3.57643736
73regulation of interleukin-5 production (GO:0032674)3.57481124
74retinoic acid metabolic process (GO:0042573)3.56456291
75antibacterial humoral response (GO:0019731)3.54267291
76epoxygenase P450 pathway (GO:0019373)3.52846148
77cilium assembly (GO:0042384)3.52322302
78homocysteine metabolic process (GO:0050667)3.51640229
79retinol metabolic process (GO:0042572)3.51129525
80striated muscle atrophy (GO:0014891)3.45576306
81excretion (GO:0007588)3.45199536
82sodium ion homeostasis (GO:0055078)3.43568631
83digestive system process (GO:0022600)3.43238271
84fucose catabolic process (GO:0019317)3.42902991
85L-fucose metabolic process (GO:0042354)3.42902991
86L-fucose catabolic process (GO:0042355)3.42902991
87hepatocyte apoptotic process (GO:0097284)3.42817828
88thrombin receptor signaling pathway (GO:0070493)3.42409229
89vitamin transport (GO:0051180)3.41933779
90regulation of cell-cell adhesion mediated by cadherin (GO:2000047)3.41221988
91antimicrobial humoral response (GO:0019730)3.40836661
92regulation of interleukin-13 production (GO:0032656)3.38750461
93pyrimidine ribonucleoside catabolic process (GO:0046133)3.37706713
94bicarbonate transport (GO:0015701)3.35621279
95exogenous drug catabolic process (GO:0042738)3.33526558
96galactose catabolic process (GO:0019388)3.31910043
97regulation of cholesterol homeostasis (GO:2000188)3.30486254
98negative regulation of B cell mediated immunity (GO:0002713)3.29914576
99negative regulation of immunoglobulin mediated immune response (GO:0002890)3.29914576
100nucleotide-sugar biosynthetic process (GO:0009226)3.28188725
101positive regulation of epidermal cell differentiation (GO:0045606)3.25122260
102cysteine metabolic process (GO:0006534)3.21977305
103positive regulation of tolerance induction (GO:0002645)3.19433341
104regulation of systemic arterial blood pressure by renin-angiotensin (GO:0003081)3.17912291
105glutathione biosynthetic process (GO:0006750)3.15098851
106positive regulation of guanylate cyclase activity (GO:0031284)3.14729768
107water homeostasis (GO:0030104)3.14613467
108urate metabolic process (GO:0046415)3.13976633
109angiotensin maturation (GO:0002003)3.12433062
110diol metabolic process (GO:0034311)3.09762772
111sulfation (GO:0051923)3.09689228
112regulation of water loss via skin (GO:0033561)3.09545932
113regulation of microtubule-based movement (GO:0060632)3.09306508
114interferon-gamma secretion (GO:0072643)3.09075392
115phosphate ion transport (GO:0006817)3.05558231
116ribonucleoside bisphosphate metabolic process (GO:0033875)3.04791411
117nucleoside bisphosphate metabolic process (GO:0033865)3.04791411
118purine nucleoside bisphosphate metabolic process (GO:0034032)3.04791411
119sphingomyelin metabolic process (GO:0006684)3.04393717
120establishment or maintenance of monopolar cell polarity (GO:0061339)3.04144683
121establishment of monopolar cell polarity (GO:0061162)3.04144683
122response to hepatocyte growth factor (GO:0035728)3.01683536
123cellular response to hepatocyte growth factor stimulus (GO:0035729)3.01683536
124skeletal muscle adaptation (GO:0043501)3.00097741
125regulation of germinal center formation (GO:0002634)2.99798504
126phosphate ion transmembrane transport (GO:0035435)2.98224803
127positive regulation of respiratory burst (GO:0060267)2.96873110
128centriole assembly (GO:0098534)2.96472096
129regulation of vitamin metabolic process (GO:0030656)2.96337174
130branching involved in labyrinthine layer morphogenesis (GO:0060670)2.95977665
131nonribosomal peptide biosynthetic process (GO:0019184)2.94979103
132oligosaccharide catabolic process (GO:0009313)2.94842273
133carnitine transmembrane transport (GO:1902603)2.90987511
134positive regulation of protein targeting to membrane (GO:0090314)2.90806895
135regulation of calcineurin-NFAT signaling cascade (GO:0070884)2.90776377
136intestinal cholesterol absorption (GO:0030299)2.89203112
137phenol-containing compound catabolic process (GO:0019336)2.89139552
138fucose metabolic process (GO:0006004)2.88837440
139cell projection assembly (GO:0030031)2.88062709
140protein localization to cilium (GO:0061512)2.87389522
141negative regulation of T cell differentiation in thymus (GO:0033085)2.86990694
142microtubule-based movement (GO:0007018)2.86400569
143cellular ketone body metabolic process (GO:0046950)2.85285366
144carnitine transport (GO:0015879)2.84840811
145amino-acid betaine transport (GO:0015838)2.84840811
146regulation of autophagic vacuole assembly (GO:2000785)2.84539320
147progesterone metabolic process (GO:0042448)2.84325462
148drug metabolic process (GO:0017144)2.81100545
149cellular glucuronidation (GO:0052695)2.80747089
150glutathione derivative biosynthetic process (GO:1901687)2.80453585
151glutathione derivative metabolic process (GO:1901685)2.80453585
152ventricular cardiac muscle cell action potential (GO:0086005)2.79432914
153pantothenate metabolic process (GO:0015939)2.78612656
154thyroid hormone metabolic process (GO:0042403)2.76608115
155carnitine metabolic process (GO:0009437)2.76394194
156protein O-linked glycosylation (GO:0006493)2.76205221
157macrophage chemotaxis (GO:0048246)2.75780339
158cellular component assembly involved in morphogenesis (GO:0010927)2.74834813
159positive regulation of Cdc42 GTPase activity (GO:0043089)2.74460883
160hydrogen peroxide catabolic process (GO:0042744)2.74428108
161muscle atrophy (GO:0014889)2.74242183
162keratinocyte development (GO:0003334)2.72814247
163glutathione metabolic process (GO:0006749)2.72321875
164iron ion import (GO:0097286)2.71879390
165NADH metabolic process (GO:0006734)2.67841577
166cytoplasmic microtubule organization (GO:0031122)2.65380195
167uronic acid metabolic process (GO:0006063)2.62346980
168glucuronate metabolic process (GO:0019585)2.62346980
169quaternary ammonium group transport (GO:0015697)2.55615483
170digestion (GO:0007586)2.55532944
171establishment or maintenance of apical/basal cell polarity (GO:0035088)2.53704972
172establishment or maintenance of bipolar cell polarity (GO:0061245)2.53704972
173axonemal dynein complex assembly (GO:0070286)15.7588000
174cilium or flagellum-dependent cell motility (GO:0001539)13.0489002
175cilium movement (GO:0003341)10.9749893
176motile cilium assembly (GO:0044458)10.6443861

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TP63_17297297_ChIP-ChIP_HaCaT_Human6.93190008
2CDX2_20551321_ChIP-Seq_CACO-2_Human4.40814587
3SOX2_27498859_Chip-Seq_STOMACH_Mouse3.82982509
4TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse3.04514925
5* SOX2_20726797_ChIP-Seq_SW620_Human2.89054276
6CDX2_19796622_ChIP-Seq_MESCs_Mouse2.86691093
7GATA4_25053715_ChIP-Seq_YYC3_Human2.79298462
8GATA6_25053715_ChIP-Seq_YYC3_Human2.70432947
9ESR1_17901129_ChIP-ChIP_LIVER_Mouse2.70057849
10ESR1_21235772_ChIP-Seq_MCF-7_Human2.61403546
11DROSHA_22980978_ChIP-Seq_HELA_Human2.58215626
12PPARA_22158963_ChIP-Seq_LIVER_Mouse2.45862367
13STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse2.44617391
14HNF4A_19761587_ChIP-ChIP_CACO-2_Human2.43039911
15ESR2_21235772_ChIP-Seq_MCF-7_Human2.41134437
16RXR_22158963_ChIP-Seq_LIVER_Mouse2.22218866
17SMAD4_19686287_ChIP-ChIP_HaCaT_Human2.19905397
18PPARG_19300518_ChIP-PET_3T3-L1_Mouse2.19102930
19CHD7_19251738_ChIP-ChIP_MESCs_Mouse2.16759499
20SRY_22984422_ChIP-ChIP_TESTIS_Rat2.15004760
21ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse2.04050277
22* NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.96966574
23NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.92206248
24AR_21909140_ChIP-Seq_LNCAP_Human1.90935410
25LXR_22158963_ChIP-Seq_LIVER_Mouse1.88631411
26TRIM28_21343339_ChIP-Seq_HEK293_Human1.87157580
27PPAR_26484153_Chip-Seq_NCI-H1993_Human1.83717338
28SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.83395213
29RARG_19884340_ChIP-ChIP_MEFs_Mouse1.80956470
30* RACK7_27058665_Chip-Seq_MCF-7_Human1.80586622
31BMI1_19503595_ChIP-Seq_MEFsC_Mouse1.79649417
32ESR1_20079471_ChIP-ChIP_T-47D_Human1.78905118
33KLF5_25053715_ChIP-Seq_YYC3_Human1.77536021
34IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.77266201
35TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.74993619
36RUNX1_27514584_Chip-Seq_MCF-7_Human1.74436843
37FOXO3_23340844_ChIP-Seq_DLD1_Human1.72155681
38KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.70551860
39KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.66909100
40VDR_22108803_ChIP-Seq_LS180_Human1.64781599
41ESR1_15608294_ChIP-ChIP_MCF-7_Human1.61863985
42PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.59011402
43STAT1_20625510_ChIP-Seq_HELA_Human1.56937334
44* KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.55175968
45ATF3_27146783_Chip-Seq_COLON_Human1.53498523
46TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.51487110
47ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.50521651
48POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.47444940
49PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.46513370
50ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.45917448
51AHR_22903824_ChIP-Seq_MCF-7_Human1.45758051
52SMC4_20622854_ChIP-Seq_HELA_Human1.44158065
53RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.42759269
54ZNF263_19887448_ChIP-Seq_K562_Human1.40778161
55TCF4_18268006_ChIP-ChIP_LS174T_Human1.38260173
56GATA1_19941826_ChIP-Seq_K562_Human1.37773883
57CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.34579359
58PIAS1_25552417_ChIP-Seq_VCAP_Human1.34407527
59FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human1.32732762
60CLOCK_20551151_ChIP-Seq_293T_Human1.30840378
61RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.29436524
62GATA3_24758297_ChIP-Seq_MCF-7_Human1.28462921
63SOX9_24532713_ChIP-Seq_HFSC_Mouse1.28400830
64TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.22385560
65FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.22054953
66SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.19324963
67SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.19324963
68TP63_23658742_ChIP-Seq_EP156T_Human1.19200144
69STAT6_21828071_ChIP-Seq_BEAS2B_Human1.18196737
70* FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human1.17056557
71* AR_21915096_ChIP-Seq_LNCaP-1F5_Human1.16515384
72CTNNB1_20460455_ChIP-Seq_HCT116_Human1.15185523
73ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.14291969
74CTCF_27219007_Chip-Seq_Bcells_Human1.12941215
75FOXA1_25552417_ChIP-Seq_VCAP_Human1.11852350
76CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.11329154
77TCF3_18692474_ChIP-Seq_MEFs_Mouse1.10772965
78ARNT_22903824_ChIP-Seq_MCF-7_Human1.09794112
79EGR1_23403033_ChIP-Seq_LIVER_Mouse1.08814417
80JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.07730965
81GATA3_20176728_ChIP-ChIP_TSCs_Mouse1.07604347
82OCT4_18692474_ChIP-Seq_MEFs_Mouse1.07498932
83IKZF1_21737484_ChIP-ChIP_HCT116_Human1.06933952
84EGR1_19032775_ChIP-ChIP_M12_Human1.06899284
85P63_26484246_Chip-Seq_KERATINOCYTES_Human1.06735553
86* LXR_22292898_ChIP-Seq_THP-1_Human1.06426843
87BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.06297582
88FOXA1_26743006_Chip-Seq_LNCaP-abl_Human1.06293682
89GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.05948291
90SALL4_18804426_ChIP-ChIP_XEN_Mouse1.05693495
91CEBPB_22108803_ChIP-Seq_LS180_Human1.05097031
92NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.04451503
93* NANOG_18692474_ChIP-Seq_MEFs_Mouse1.04238080
94PPARD_23208498_ChIP-Seq_MDA-MB-231_Human1.04157706
95MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.04109736
96* SMAD2/3_21741376_ChIP-Seq_ESCs_Human1.03212310
97HNF4A_19822575_ChIP-Seq_HepG2_Human1.01412734
98P68_20966046_ChIP-Seq_HELA_Human1.00460836
99* CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human0.99730255
100CREB1_26743006_Chip-Seq_LNCaP_Human0.98145468
101STAT3_1855785_ChIP-Seq_MESCs_Mouse0.96281082
102PHF8_20622854_ChIP-Seq_HELA_Human0.96151938
103THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse0.95287346
104GATA2_19941826_ChIP-Seq_K562_Human0.94777807
105BCOR_27268052_Chip-Seq_Bcells_Human0.94456908
106RXR_22108803_ChIP-Seq_LS180_Human0.94036026
107NR3C1_21868756_ChIP-Seq_MCF10A_Human0.93511062
108UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human0.93297082
109CTCF_20526341_ChIP-Seq_ESCs_Human0.92824538
110TP63_22573176_ChIP-Seq_HFKS_Human0.91867529
111FOXO1_23066095_ChIP-Seq_LIVER_Mouse0.91153286
112ZNF217_24962896_ChIP-Seq_MCF-7_Human0.90447129
113RAD21_21589869_ChIP-Seq_MESCs_Mouse0.89526192
114IRF8_22096565_ChIP-ChIP_GC-B_Human0.88025797
115FOXM1_26456572_ChIP-Seq_MCF-7_Human0.87398164
116TDRD3_21172665_ChIP-Seq_MCF-7_Human0.87081948
117* PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.86762292
118P300_27268052_Chip-Seq_Bcells_Human0.86671079
119KAP1_22055183_ChIP-Seq_ESCs_Mouse0.86301026
120TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.85912103
121ELF1_20517297_ChIP-Seq_JURKAT_Human0.85390945
122HIF1A_21447827_ChIP-Seq_MCF-7_Human0.84986864
123BCL6_27268052_Chip-Seq_Bcells_Human0.84932848
124SA1_27219007_Chip-Seq_Bcells_Human0.84603768
125EOMES_20176728_ChIP-ChIP_TSCs_Mouse0.84311419
126TCF7L2_21901280_ChIP-Seq_H4IIE_Rat0.83591041
127HNFA_21074721_ChIP-Seq_CACO-2_Human0.83120634
128* FOXA2_19822575_ChIP-Seq_HepG2_Human0.81851712
129YY1_22570637_ChIP-Seq_MALME-3M_Human0.81452236
130CDX2_22108803_ChIP-Seq_LS180_Human0.81386333
131TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.80777630
132ETV1_20927104_ChIP-Seq_GIST48_Human0.80654099
133CDX2_21074721_ChIP-Seq_CACO-2_Mouse0.79912486
134GATA2_21666600_ChIP-Seq_HMVEC_Human0.79354248
135SMAD3_22036565_ChIP-Seq_ESCs_Mouse0.79228233
136* NANOG_18692474_ChIP-Seq_MESCs_Mouse0.79038062
137* E2F1_20622854_ChIP-Seq_HELA_Human0.78951783
138PCGF4_22325352_ChIP-Seq_293T-Rex_Human0.78170432
139* SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.76404827

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0010234_abnormal_vibrissa_follicle9.01238584
2MP0005360_urolithiasis4.12713029
3MP0004264_abnormal_extraembryonic_tissu4.01531320
4MP0002132_abnormal_respiratory_system3.87840238
5MP0003283_abnormal_digestive_organ3.54957976
6MP0002653_abnormal_ependyma_morphology3.47364214
7MP0001666_abnormal_nutrient_absorption3.34052177
8MP0005377_hearing/vestibular/ear_phenot3.19207502
9MP0003878_abnormal_ear_physiology3.19207502
10MP0003866_abnormal_defecation3.02883370
11MP0009780_abnormal_chondrocyte_physiolo2.83646457
12MP0000462_abnormal_digestive_system2.77282213
13MP0003315_abnormal_perineum_morphology2.67433377
14MP0002822_catalepsy2.66415648
15MP0004043_abnormal_pH_regulation2.64731119
16MP0009379_abnormal_foot_pigmentation2.52554057
17MP0004019_abnormal_vitamin_homeostasis2.41613200
18MP0000566_synostosis2.32674961
19MP0001873_stomach_inflammation2.31243532
20MP0005085_abnormal_gallbladder_physiolo2.28524149
21MP0008875_abnormal_xenobiotic_pharmacok2.25867368
22MP0001765_abnormal_ion_homeostasis2.24965094
23MP0000537_abnormal_urethra_morphology2.23565594
24MP0000678_abnormal_parathyroid_gland2.12605679
25MP0009643_abnormal_urine_homeostasis2.11033530
26MP0001663_abnormal_digestive_system2.10257419
27MP0005381_digestive/alimentary_phenotyp2.06932460
28MP0010155_abnormal_intestine_physiology2.05260008
29MP0002139_abnormal_hepatobiliary_system1.99093766
30MP0010352_gastrointestinal_tract_polyps1.97165398
31MP0010678_abnormal_skin_adnexa1.95731031
32MP0000477_abnormal_intestine_morphology1.94010583
33MP0000490_abnormal_crypts_of1.92187347
34MP0001664_abnormal_digestion1.89173628
35MP0002796_impaired_skin_barrier1.86689318
36MP0000538_abnormal_urinary_bladder1.76632401
37MP0005636_abnormal_mineral_homeostasis1.74286713
38MP0005365_abnormal_bile_salt1.73870543
39MP0003705_abnormal_hypodermis_morpholog1.73456431
40MP0005167_abnormal_blood-brain_barrier1.71392728
41MP0003806_abnormal_nucleotide_metabolis1.70129858
42MP0003252_abnormal_bile_duct1.69203593
43MP0003183_abnormal_peptide_metabolism1.62340124
44MP0001756_abnormal_urination1.61565003
45MP0005409_darkened_coat_color1.56309505
46MP0005083_abnormal_biliary_tract1.52292522
47MP0005310_abnormal_salivary_gland1.51618184
48MP0003300_gastrointestinal_ulcer1.45717083
49MP0005058_abnormal_lysosome_morphology1.45250591
50MP0000465_gastrointestinal_hemorrhage1.40815827
51MP0001984_abnormal_olfaction1.36139150
52MP0005332_abnormal_amino_acid1.34628561
53MP0002136_abnormal_kidney_physiology1.34337467
54MP0002168_other_aberrant_phenotype1.33711801
55MP0003191_abnormal_cellular_cholesterol1.32484864
56MP0002876_abnormal_thyroid_physiology1.31005565
57MP0005165_increased_susceptibility_to1.29871906
58MP0006054_spinal_hemorrhage1.27545519
59MP0002234_abnormal_pharynx_morphology1.27028692
60MP0004133_heterotaxia1.26521636
61MP0002098_abnormal_vibrissa_morphology1.24461512
62MP0008789_abnormal_olfactory_epithelium1.23012889
63MP0008004_abnormal_stomach_pH1.20367870
64MP0009053_abnormal_anal_canal1.20089982
65MP0001849_ear_inflammation1.17367987
66MP0002138_abnormal_hepatobiliary_system1.15394655
67MP0005501_abnormal_skin_physiology1.09265701
68MP0004947_skin_inflammation1.06829704
69MP0000470_abnormal_stomach_morphology1.05636879
70MP0005623_abnormal_meninges_morphology1.05195351
71MP0003453_abnormal_keratinocyte_physiol1.04410523
72MP0001216_abnormal_epidermal_layer1.02630058
73MP0003868_abnormal_feces_composition1.01248003
74MP0004782_abnormal_surfactant_physiolog1.00958996
75MP0002249_abnormal_larynx_morphology1.00886915
76MP0001485_abnormal_pinna_reflex0.98652018
77MP0004185_abnormal_adipocyte_glucose0.96889141
78MP0003303_peritoneal_inflammation0.95190423
79MP0005395_other_phenotype0.94012290
80MP0005166_decreased_susceptibility_to0.93238459
81MP0000681_abnormal_thyroid_gland0.92400973
82MP0003566_abnormal_cell_adhesion0.89025646
83MP0005084_abnormal_gallbladder_morpholo0.88573811
84MP0010329_abnormal_lipoprotein_level0.87385538
85MP0005319_abnormal_enzyme/_coenzyme0.86494087
86MP0002166_altered_tumor_susceptibility0.86122207
87MP0003045_fibrosis0.85023946
88MP0001188_hyperpigmentation0.79831900
89MP0000377_abnormal_hair_follicle0.79346843
90MP0003941_abnormal_skin_development0.77952880
91MP0005257_abnormal_intraocular_pressure0.77615672
92MP0005451_abnormal_body_composition0.76707582
93MP0003656_abnormal_erythrocyte_physiolo0.76386984
94MP0001346_abnormal_lacrimal_gland0.76379761
95MP0000762_abnormal_tongue_morphology0.72379332
96MP0000467_abnormal_esophagus_morphology0.70344106
97MP0002282_abnormal_trachea_morphology0.67405753
98MP0005670_abnormal_white_adipose0.65743112
99MP0002060_abnormal_skin_morphology0.65058039
100MP0000383_abnormal_hair_follicle0.65019777
101MP0002118_abnormal_lipid_homeostasis0.64995882
102MP0008872_abnormal_physiological_respon0.63494102
103MP0004147_increased_porphyrin_level0.63453915
104MP0002160_abnormal_reproductive_system0.62798956
105MP0001764_abnormal_homeostasis0.62731703
106MP0001790_abnormal_immune_system0.62141060
107MP0005387_immune_system_phenotype0.62141060
108MP0005666_abnormal_adipose_tissue0.60758395
109MP0002896_abnormal_bone_mineralization0.59782490
110MP0000516_abnormal_urinary_system0.58499470
111MP0005367_renal/urinary_system_phenotyp0.58499470
112MP0002009_preneoplasia0.58450034
113MP0005164_abnormal_response_to0.57864525
114MP0000858_altered_metastatic_potential0.57611882
115MP0005584_abnormal_enzyme/coenzyme_acti0.57479653
116MP0004858_abnormal_nervous_system0.55938480
117MP0006082_CNS_inflammation0.55747337
118MP0005023_abnormal_wound_healing0.55255937
119MP0000613_abnormal_salivary_gland0.52797028
120MP0000609_abnormal_liver_physiology0.52282519
121MP0004272_abnormal_basement_membrane0.51677947
122MP0009840_abnormal_foam_cell0.51089842
123MP0004484_altered_response_of0.48916259
124MP0010771_integument_phenotype0.47898355
125MP0002135_abnormal_kidney_morphology0.47374532
126MP0009384_cardiac_valve_regurgitation0.46414908
127MP0002909_abnormal_adrenal_gland0.46038957
128MP0003693_abnormal_embryo_hatching0.46027654
129MP0003075_altered_response_to0.45726366
130MP0002277_abnormal_respiratory_mucosa0.45340147
131MP0009642_abnormal_blood_homeostasis0.44839490
132MP0001845_abnormal_inflammatory_respons0.43626934
133MP0003879_abnormal_hair_cell0.43606525
134MP0009785_altered_susceptibility_to0.43398069
135MP0008873_increased_physiological_sensi0.41386683
136MP0005187_abnormal_penis_morphology0.41223721

Predicted human phenotypes

RankGene SetZ-score
1Abnormal respiratory motile cilium physiology (HP:0012261)9.92556683
2Absent/shortened dynein arms (HP:0200106)9.72693912
3Dynein arm defect of respiratory motile cilia (HP:0012255)9.72693912
4Abnormal ciliary motility (HP:0012262)9.66658966
5Rhinitis (HP:0012384)9.28928123
6Chronic bronchitis (HP:0004469)7.86653481
7Bronchiectasis (HP:0002110)7.10736087
8Nasal polyposis (HP:0100582)6.67528707
9Hyperactive renin-angiotensin system (HP:0000841)6.30879240
10Abnormality of the nasal mucosa (HP:0000433)5.81716987
11Metabolic alkalosis (HP:0200114)5.60305010
12Flat acetabular roof (HP:0003180)5.14105950
13Ileus (HP:0002595)5.08894949
14Right ventricular cardiomyopathy (HP:0011663)4.94823219
15Abnormality of chloride homeostasis (HP:0011422)4.89350680
16Abnormal tarsal ossification (HP:0008369)4.51019668
17Bronchitis (HP:0012387)4.42707247
18Abnormality of the 1st metacarpal (HP:0010009)4.37098514
19Recurrent sinusitis (HP:0011108)4.24203812
20Pustule (HP:0200039)3.94852537
21Abnormality of renin-angiotensin system (HP:0000847)3.93732520
22Infertility (HP:0000789)3.93638740
23Malnutrition (HP:0004395)3.88695867
24Abnormality of carpal bone ossification (HP:0006257)3.87789978
25Chronic sinusitis (HP:0011109)3.85505485
26Male infertility (HP:0003251)3.78185844
27Recurrent otitis media (HP:0000403)3.71093809
28Abdominal distention (HP:0003270)3.55077855
29Abnormality of the distal phalanx of the thumb (HP:0009617)3.53084501
30Cupped ribs (HP:0000887)3.46100070
31Hyperaldosteronism (HP:0000859)3.43323027
32Pili torti (HP:0003777)3.40464144
33Vacuolated lymphocytes (HP:0001922)3.39496906
34Abnormality of small intestinal villus morphology (HP:0011472)3.36910207
35Villous atrophy (HP:0011473)3.36910207
36Abnormality of glutamine family amino acid metabolism (HP:0010902)3.36577875
37Symphalangism affecting the phalanges of the hand (HP:0009773)3.31001949
38Abnormal foot bone ossification (HP:0010675)3.13729179
39Chronic otitis media (HP:0000389)3.09297627
40Neonatal short-limb short stature (HP:0008921)3.07645860
41Fragile nails (HP:0001808)3.05989699
42Alkalosis (HP:0001948)3.05685275
43Gout (HP:0001997)3.05329522
44Short phalanx of the thumb (HP:0009660)3.00166367
45Dehydration (HP:0001944)2.99633676
46Abnormal ossification of hand bones (HP:0005921)2.95248405
47Atelectasis (HP:0100750)2.94414456
48Occipital encephalocele (HP:0002085)2.90840023
49Abnormal hand bone ossification (HP:0010660)2.85923748
50Increased circulating renin level (HP:0000848)2.81670457
51Abnormality of the 2nd finger (HP:0004100)2.79528934
52Hyperglycinuria (HP:0003108)2.77669244
53Hypokalemia (HP:0002900)2.71028260
54Breech presentation (HP:0001623)2.68526362
55Biliary tract neoplasm (HP:0100574)2.66046585
56Hypomagnesemia (HP:0002917)2.65458471
57Abnormality of magnesium homeostasis (HP:0004921)2.64458365
58Ureteral stenosis (HP:0000071)2.61723468
59Abnormality of the proximal phalanges of the hand (HP:0009834)2.61098120
60Proximal tubulopathy (HP:0000114)2.59691811
61Onycholysis (HP:0001806)2.58703840
62Increased purine levels (HP:0004368)2.56446354
63Hyperuricemia (HP:0002149)2.56446354
64Abnormal cartilage morphology (HP:0002763)2.56139754
65Flattened epiphyses (HP:0003071)2.55475606
66True hermaphroditism (HP:0010459)2.48762260
67Hypokalemic alkalosis (HP:0001949)2.47150373
68Milia (HP:0001056)2.44167025
69Abnormality of the middle phalanges of the toes (HP:0010183)2.42887588
70Vertebral clefting (HP:0008428)2.41890715
71Decreased circulating renin level (HP:0003351)2.41393769
72Abnormality of monocarboxylic acid metabolism (HP:0010996)2.40528513
73Woolly hair (HP:0002224)2.40289861
74Abnormality of purine metabolism (HP:0004352)2.39984169
75Hyperkalemia (HP:0002153)2.39926188
76Pancreatic fibrosis (HP:0100732)2.38232646
77Ureteral obstruction (HP:0006000)2.37182922
78Aplasia/Hypoplasia involving the femoral head and neck (HP:0009108)2.37038300
79Short middle phalanx of finger (HP:0005819)2.34273887
80Aplasia/Hypoplasia of the phalanges of the thumb (HP:0009658)2.33739820
81Abnormality of renal excretion (HP:0011036)2.32679681
82Shawl scrotum (HP:0000049)2.32227223
83Cystic liver disease (HP:0006706)2.30500571
84Renal salt wasting (HP:0000127)2.29516812
85Posterior subcapsular cataract (HP:0007787)2.29316335
86Chronic diarrhea (HP:0002028)2.27086707
87Alopecia of scalp (HP:0002293)2.24984528
88Flat capital femoral epiphysis (HP:0003370)2.24542343
89Short hallux (HP:0010109)2.24382430
90Mildly elevated creatine phosphokinase (HP:0008180)2.23143994
91Hydroxyprolinuria (HP:0003080)2.22727390
92Abnormality of proline metabolism (HP:0010907)2.22727390
93Progressive sensorineural hearing impairment (HP:0000408)2.21947088
94Gastrointestinal dysmotility (HP:0002579)2.21689652
95Abnormal biliary tract morphology (HP:0012440)2.20720871
96Atrophic scars (HP:0001075)2.18328126
97Widely patent fontanelles and sutures (HP:0004492)2.18260280
98Hoarse voice (HP:0001609)2.18237336
99Spinal cord compression (HP:0002176)2.17495214
100Tracheal stenosis (HP:0002777)2.17031038
101Tetany (HP:0001281)2.16983900
102Cone-rod dystrophy (HP:0000548)2.15480739
103Micronodular cirrhosis (HP:0001413)2.15427486
104Palpitations (HP:0001962)2.12798315
105Focal segmental glomerulosclerosis (HP:0000097)2.12588665
106Abnormality of potassium homeostasis (HP:0011042)2.11148083
107Aplasia/Hypoplasia of the phalanges of the toes (HP:0010173)2.10225869
108Abnormality of the phalanges of the hallux (HP:0010057)2.08005071
109Cheilitis (HP:0100825)2.07223568
110Recurrent bronchitis (HP:0002837)2.06244210
111Congenital ichthyosiform erythroderma (HP:0007431)2.05880817
112Abnormal vertebral ossification (HP:0100569)2.04932744
113Aplasia/hypoplasia of the femur (HP:0005613)2.04522671
114Esophageal varix (HP:0002040)2.04182142
115Aplasia/Hypoplasia of the hallux (HP:0008362)2.03277790
116Hyponatremia (HP:0002902)2.03048643
117Abnormal urine output (HP:0012590)2.02539781
118Intrahepatic cholestasis (HP:0001406)2.01440375
119Myopathic facies (HP:0002058)2.01150208
120Glycosuria (HP:0003076)2.00035069
121Abnormality of urine glucose concentration (HP:0011016)2.00035069
122Respiratory insufficiency due to defective ciliary clearance (HP:0200073)11.4564457
123Abnormal respiratory epithelium morphology (HP:0012253)10.1420529
124Abnormal respiratory motile cilium morphology (HP:0005938)10.1420529
125Aplasia/Hypoplasia of the 1st metacarpal (HP:0010026)1.99629919
126Short 1st metacarpal (HP:0010034)1.99629919
127Visceral angiomatosis (HP:0100761)1.98270338
128Tubulointerstitial nephritis (HP:0001970)1.95861690
129Pancreatic cysts (HP:0001737)1.85474025
130Abnormality of midbrain morphology (HP:0002418)1.82687985
131Molar tooth sign on MRI (HP:0002419)1.82687985
132Bell-shaped thorax (HP:0001591)1.81042546
133Nephronophthisis (HP:0000090)1.79688625
134Fat malabsorption (HP:0002630)1.79209859
135Chronic hepatic failure (HP:0100626)1.74887924
136Abnormality of the distal phalanges of the toes (HP:0010182)1.70302993
137Postaxial foot polydactyly (HP:0001830)1.69737487
138Hemorrhage of the eye (HP:0011885)1.56177224
139Hypotension (HP:0002615)1.56156464
140Abnormality of sodium homeostasis (HP:0010931)1.49687135
141Tubular atrophy (HP:0000092)1.49642958
142Male pseudohermaphroditism (HP:0000037)1.49535185
143Abnormality of the renal medulla (HP:0100957)1.47924877
144Congenital hepatic fibrosis (HP:0002612)1.47172282
145Vascular calcification (HP:0004934)1.43665641
146Nephropathy (HP:0000112)1.42899108
147Adrenal overactivity (HP:0002717)1.42076382
148Abnormality of permanent molar morphology (HP:0011071)1.37246425
149Abnormality of the dental root (HP:0006486)1.37246425
150Taurodontia (HP:0000679)1.37246425
151Hand muscle atrophy (HP:0009130)1.37182815
152Lip pit (HP:0100267)1.35726402
153Abnormality of vitamin metabolism (HP:0100508)1.34796335
154Bifid scrotum (HP:0000048)1.34397871
155Absent frontal sinuses (HP:0002688)1.34244410
156Abnormal glucose tolerance (HP:0001952)1.33572659
157Furrowed tongue (HP:0000221)1.32523349
158Ventricular fibrillation (HP:0001663)1.31664780
159Asplenia (HP:0001746)1.31595895
160Aplasia/Hypoplasia of the spleen (HP:0010451)1.31302450
161Short thorax (HP:0010306)1.30445461
162Anencephaly (HP:0002323)1.27719514
163Abnormality of molar morphology (HP:0011070)1.26092332
164Abnormality of molar (HP:0011077)1.26092332
165Upper limb amyotrophy (HP:0009129)1.25930724
166Distal upper limb amyotrophy (HP:0007149)1.25930724
167Hyperphosphatemia (HP:0002905)1.24565176
168Glucose intolerance (HP:0000833)1.23489544
169Abnormality of the dental pulp (HP:0006479)1.21727646
170Stridor (HP:0010307)1.21688977
171Cardiovascular calcification (HP:0011915)1.21013623
172Steatorrhea (HP:0002570)1.20893756
173Popliteal pterygium (HP:0009756)1.20783029
174Short nail (HP:0001799)1.20647996

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAPK157.64861995
2TAOK35.87905177
3MST1R5.45600369
4PIK3CA5.27755322
5FRK4.16798016
6MST43.53118347
7RIPK13.44847774
8MAP2K23.28848046
9EPHA23.11590910
10EPHB22.75995025
11LMTK22.60173521
12MAP3K22.59346743
13ACVR1B2.52242862
14SMG12.29522216
15KSR22.15133927
16NME12.05591329
17MYLK1.95830456
18STK241.95106023
19MET1.89970303
20WNK41.88429305
21TAOK11.88213508
22GRK61.79793680
23PRKG21.73101877
24OXSR11.61447777
25TESK11.49899087
26EPHA31.47214038
27AKT31.45796259
28PTK21.33311215
29PTK61.31741452
30MAP2K11.31106033
31WNK31.27852210
32PRKCI1.22734118
33STK391.14101120
34TBK11.06646813
35PDK20.99243333
36FGFR40.98247715
37STK100.94752070
38MAP3K80.93475676
39CAMK2D0.92841286
40ERN10.90162829
41NEK60.88863935
42BCR0.86136408
43EEF2K0.85619470
44PAK40.82122145
45RIPK40.81945138
46FER0.80678444
47MAP3K30.78206545
48ARAF0.77918331
49DMPK0.77906815
50DDR20.75739453
51MARK20.73574480
52TTK0.72553796
53MATK0.70438504
54MAP3K140.67660333
55PDPK10.67034204
56FGFR30.65440359
57PTK2B0.62245585
58RPS6KB20.60867500
59MAP3K10.60284470
60ERBB20.59870238
61NEK10.59047854
62MAP3K100.57373624
63TYK20.56333826
64IRAK10.56319528
65MAP3K90.55244385
66STK38L0.54687526
67TRPM70.52961773
68STK380.52363175
69LRRK20.50311711
70BRSK20.49420471
71IKBKE0.47036681
72BCKDK0.45227315
73LATS10.45200368
74GRK10.44390820
75LIMK10.43405359
76PRKD20.42361644
77MELK0.42305924
78EPHB10.41795759
79AURKB0.41425110
80CAMK2G0.41142160
81PRKD30.40282000
82PDK10.40241048
83HIPK20.39310684
84PRKCD0.38230187
85MAPK110.38157756
86PRKAA20.37948790
87PAK10.37890921
88MAP3K70.37420755
89CAMK2B0.37192207
90MAP3K120.37078906
91MAP2K60.36866915
92CAMKK10.35759511
93STK110.35585486
94TESK20.34267739
95MAPKAPK30.33768399
96ICK0.33759409
97DYRK1B0.32999697
98ZAP700.31541738
99PIK3CG0.30969716
100SRC0.30829308
101NUAK10.29782346
102PRKCA0.29613865
103ERBB40.29606454
104PRKCQ0.29301663
105MAP3K110.27986487
106SGK10.26462310
107PDK30.26116461
108PDK40.26116461
109RET0.25929632
110RPS6KA20.25169335
111TNK20.23184646
112PAK30.22850029
113YES10.22653439
114PRKAA10.21752619
115CAMK1D0.21551035
116TLK10.21427838
117PRKCZ0.21135107
118CSK0.21066443
119PAK20.21048296
120FYN0.20322742
121TRIB30.20092103
122PIM20.19545069
123BMX0.18646547
124PKN20.18293070
125ERBB30.17247836
126DAPK30.16429622
127CDK60.16063179
128NLK0.14682480
129ROCK10.13954434
130IGF1R0.12947459
131CDC42BPA0.12470071
132SGK4940.11943343
133SGK2230.11943343
134ILK0.11914111
135TTN0.11737833
136RPS6KA10.11443266
137WNK10.11250646
138MAP2K30.10653759

Predicted pathways (KEGG)

RankGene SetZ-score
1Sulfur metabolism_Homo sapiens_hsa009205.76104600
2Mineral absorption_Homo sapiens_hsa049784.29981398
3Bile secretion_Homo sapiens_hsa049762.96544704
4Butirosin and neomycin biosynthesis_Homo sapiens_hsa005242.68066284
5Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006012.61215451
6Tyrosine metabolism_Homo sapiens_hsa003502.50281953
7Fat digestion and absorption_Homo sapiens_hsa049752.39581346
8Ascorbate and aldarate metabolism_Homo sapiens_hsa000532.27545512
9Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005122.14991153
10Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049642.14096625
11Fructose and mannose metabolism_Homo sapiens_hsa000511.95099301
12Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.93768805
13Renin-angiotensin system_Homo sapiens_hsa046141.84258174
14Pentose and glucuronate interconversions_Homo sapiens_hsa000401.83676426
15Histidine metabolism_Homo sapiens_hsa003401.76953649
16Vitamin digestion and absorption_Homo sapiens_hsa049771.76861340
17Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.74142855
18Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.73225030
19Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.63219530
20Butanoate metabolism_Homo sapiens_hsa006501.59925356
21Glutathione metabolism_Homo sapiens_hsa004801.53443964
22Tight junction_Homo sapiens_hsa045301.49865183
23Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.49265853
24Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.47471575
25Cyanoamino acid metabolism_Homo sapiens_hsa004601.44069428
26Protein digestion and absorption_Homo sapiens_hsa049741.40787430
27Galactose metabolism_Homo sapiens_hsa000521.40665962
28Tryptophan metabolism_Homo sapiens_hsa003801.38672698
29Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.31275119
30Glycerolipid metabolism_Homo sapiens_hsa005611.30181147
31Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.24498986
32Maturity onset diabetes of the young_Homo sapiens_hsa049501.23026035
33Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.22745654
34Other glycan degradation_Homo sapiens_hsa005111.22638477
35Fatty acid degradation_Homo sapiens_hsa000711.21587230
36Thyroid hormone synthesis_Homo sapiens_hsa049181.19477828
37Pancreatic secretion_Homo sapiens_hsa049721.12007100
38PPAR signaling pathway_Homo sapiens_hsa033201.09489203
39Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.08785561
40Starch and sucrose metabolism_Homo sapiens_hsa005001.08573522
41Propanoate metabolism_Homo sapiens_hsa006401.04127228
42Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.03313471
43Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.03115375
44alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.96177958
45Oxidative phosphorylation_Homo sapiens_hsa001900.94171562
46Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.93657108
47Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.92303635
48Salivary secretion_Homo sapiens_hsa049700.91020240
49Fatty acid biosynthesis_Homo sapiens_hsa000610.90957827
502-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.90923809
51Carbon metabolism_Homo sapiens_hsa012000.90830079
52Pyruvate metabolism_Homo sapiens_hsa006200.89871726
53Chemical carcinogenesis_Homo sapiens_hsa052040.88896396
54Leukocyte transendothelial migration_Homo sapiens_hsa046700.87618935
55Caffeine metabolism_Homo sapiens_hsa002320.87126039
56Hepatitis C_Homo sapiens_hsa051600.86152373
57Pentose phosphate pathway_Homo sapiens_hsa000300.85210930
58Carbohydrate digestion and absorption_Homo sapiens_hsa049730.84890983
59Folate biosynthesis_Homo sapiens_hsa007900.84724001
60Steroid hormone biosynthesis_Homo sapiens_hsa001400.83550616
61Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.81751724
62beta-Alanine metabolism_Homo sapiens_hsa004100.81416833
63Arginine and proline metabolism_Homo sapiens_hsa003300.79641685
64Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.78802628
65Huntingtons disease_Homo sapiens_hsa050160.78513638
66Salmonella infection_Homo sapiens_hsa051320.75475513
67Linoleic acid metabolism_Homo sapiens_hsa005910.69426167
68Arachidonic acid metabolism_Homo sapiens_hsa005900.69176067
69Gastric acid secretion_Homo sapiens_hsa049710.67480292
70Asthma_Homo sapiens_hsa053100.67017185
71Sphingolipid metabolism_Homo sapiens_hsa006000.66970176
72Intestinal immune network for IgA production_Homo sapiens_hsa046720.64784488
73Arginine biosynthesis_Homo sapiens_hsa002200.61893181
74Glycerophospholipid metabolism_Homo sapiens_hsa005640.60347872
75Alzheimers disease_Homo sapiens_hsa050100.59725501
76Bladder cancer_Homo sapiens_hsa052190.58448224
77Adherens junction_Homo sapiens_hsa045200.58177169
78Parkinsons disease_Homo sapiens_hsa050120.57740278
79Thyroid cancer_Homo sapiens_hsa052160.56376564
80ABC transporters_Homo sapiens_hsa020100.53574977
81Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.52077507
82Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.51914046
83Allograft rejection_Homo sapiens_hsa053300.49504152
84Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.49183305
85Peroxisome_Homo sapiens_hsa041460.49142745
86Fatty acid metabolism_Homo sapiens_hsa012120.46064398
87Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.46034287
88Autoimmune thyroid disease_Homo sapiens_hsa053200.45536149
89Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.45121636
90Metabolic pathways_Homo sapiens_hsa011000.44968027
91Phenylalanine metabolism_Homo sapiens_hsa003600.44945563
92Insulin resistance_Homo sapiens_hsa049310.44208317
93Vibrio cholerae infection_Homo sapiens_hsa051100.42935559
94Drug metabolism - other enzymes_Homo sapiens_hsa009830.42785359
95Type I diabetes mellitus_Homo sapiens_hsa049400.42302528
96Ether lipid metabolism_Homo sapiens_hsa005650.41637350
97Sulfur relay system_Homo sapiens_hsa041220.41616285
98Graft-versus-host disease_Homo sapiens_hsa053320.39592474
99Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.38267857
100Primary bile acid biosynthesis_Homo sapiens_hsa001200.37880904
101Staphylococcus aureus infection_Homo sapiens_hsa051500.36071994
102Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.31073723
103Selenocompound metabolism_Homo sapiens_hsa004500.29740073
104Notch signaling pathway_Homo sapiens_hsa043300.29703717
105Cardiac muscle contraction_Homo sapiens_hsa042600.29281998
106Steroid biosynthesis_Homo sapiens_hsa001000.29169726
107Nitrogen metabolism_Homo sapiens_hsa009100.28236066
108Retinol metabolism_Homo sapiens_hsa008300.28085314
109African trypanosomiasis_Homo sapiens_hsa051430.27590818
110Amoebiasis_Homo sapiens_hsa051460.26318465
111Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.26154430
112Pertussis_Homo sapiens_hsa051330.25398270
113N-Glycan biosynthesis_Homo sapiens_hsa005100.25045190
114Complement and coagulation cascades_Homo sapiens_hsa046100.24713377
115Renin secretion_Homo sapiens_hsa049240.24016103
116Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.23595407
117Antigen processing and presentation_Homo sapiens_hsa046120.22339172
118Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.21733514
119Cocaine addiction_Homo sapiens_hsa050300.20663401
120RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.20101390
121Toxoplasmosis_Homo sapiens_hsa051450.18253076
122Hematopoietic cell lineage_Homo sapiens_hsa046400.15770088
123Influenza A_Homo sapiens_hsa051640.15154665
124Biosynthesis of amino acids_Homo sapiens_hsa012300.15062416
125Lysosome_Homo sapiens_hsa041420.12468295
126Circadian rhythm_Homo sapiens_hsa047100.11935787
127Adipocytokine signaling pathway_Homo sapiens_hsa049200.09275959
128Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.07671203
129Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.07169631
130Phosphatidylinositol signaling system_Homo sapiens_hsa040700.06704956

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