SLC44A5

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1pyrimidine nucleobase catabolic process (GO:0006208)6.14374383
2regulation of short-term neuronal synaptic plasticity (GO:0048172)5.82124640
3regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act5.77871160
4vocalization behavior (GO:0071625)5.70355075
5locomotory exploration behavior (GO:0035641)5.68904008
6positive regulation of excitatory postsynaptic membrane potential (GO:2000463)5.66684067
7neuron cell-cell adhesion (GO:0007158)5.55902842
8regulation of glutamate receptor signaling pathway (GO:1900449)5.37954649
9ionotropic glutamate receptor signaling pathway (GO:0035235)5.29736776
10protein localization to synapse (GO:0035418)5.18365212
11synaptic vesicle maturation (GO:0016188)5.08803474
12nucleobase catabolic process (GO:0046113)4.94649132
13synaptic vesicle exocytosis (GO:0016079)4.92841499
14regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)4.82323956
15exploration behavior (GO:0035640)4.81469312
16neurotransmitter-gated ion channel clustering (GO:0072578)4.75603911
17synaptic transmission, glutamatergic (GO:0035249)4.70299445
18glutamate receptor signaling pathway (GO:0007215)4.66645352
19positive regulation of calcium ion-dependent exocytosis (GO:0045956)4.64292289
20positive regulation of synapse maturation (GO:0090129)4.44927601
21regulation of neuronal synaptic plasticity (GO:0048168)4.42551532
22neuron recognition (GO:0008038)4.39544189
23limb bud formation (GO:0060174)4.32904733
24glutamate secretion (GO:0014047)4.27668630
25regulation of long-term neuronal synaptic plasticity (GO:0048169)4.27094760
26regulation of synaptic vesicle exocytosis (GO:2000300)4.26469462
27postsynaptic membrane organization (GO:0001941)4.25876247
28neuron-neuron synaptic transmission (GO:0007270)4.23512262
29cerebral cortex radially oriented cell migration (GO:0021799)4.23107342
30axonal fasciculation (GO:0007413)4.22126594
31synaptic vesicle docking involved in exocytosis (GO:0016081)4.20126945
32regulation of synapse structural plasticity (GO:0051823)4.18378537
33dendritic spine morphogenesis (GO:0060997)4.05824179
34presynaptic membrane assembly (GO:0097105)4.05252883
35neurotransmitter secretion (GO:0007269)4.00728612
36layer formation in cerebral cortex (GO:0021819)3.98140170
37long-term memory (GO:0007616)3.97773747
38gamma-aminobutyric acid transport (GO:0015812)3.96191904
39central nervous system projection neuron axonogenesis (GO:0021952)3.95403752
40regulation of synaptic vesicle transport (GO:1902803)3.91885894
41proline transport (GO:0015824)3.86550495
42dendrite morphogenesis (GO:0048813)3.85684355
43regulation of excitatory postsynaptic membrane potential (GO:0060079)3.83703531
44positive regulation of membrane potential (GO:0045838)3.80530013
45transmission of nerve impulse (GO:0019226)3.73232149
46behavioral defense response (GO:0002209)3.72558135
47behavioral fear response (GO:0001662)3.72558135
48regulation of dendritic spine morphogenesis (GO:0061001)3.70190971
49neuronal action potential propagation (GO:0019227)3.68542669
50behavioral response to nicotine (GO:0035095)3.66837110
51presynaptic membrane organization (GO:0097090)3.66154927
52regulation of inhibitory postsynaptic membrane potential (GO:0060080)3.63324749
53regulation of postsynaptic membrane potential (GO:0060078)3.63081757
54response to pheromone (GO:0019236)3.61572579
55cell migration in hindbrain (GO:0021535)3.60369957
56regulation of synapse maturation (GO:0090128)3.57178335
57somite development (GO:0061053)3.56597193
58regulation of synaptic plasticity (GO:0048167)3.56380717
59membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.52805901
60gamma-aminobutyric acid signaling pathway (GO:0007214)3.49099882
61negative regulation of astrocyte differentiation (GO:0048712)3.48628179
62startle response (GO:0001964)3.44431641
63positive regulation of synaptic transmission, GABAergic (GO:0032230)3.44336559
64regulation of respiratory gaseous exchange by neurological system process (GO:0002087)3.43752291
65positive regulation of dendritic spine morphogenesis (GO:0061003)3.42811326
66regulation of synaptic transmission, glutamatergic (GO:0051966)3.40655377
67negative regulation of dendrite development (GO:2000171)3.40160935
68positive regulation of synaptic transmission, glutamatergic (GO:0051968)3.39584715
69response to histamine (GO:0034776)3.38476682
70negative regulation of synaptic transmission, GABAergic (GO:0032229)3.37569457
71innervation (GO:0060384)3.37538564
72long-term synaptic potentiation (GO:0060291)3.35545046
73cochlea development (GO:0090102)3.34146634
74fear response (GO:0042596)3.32952704
75retinal ganglion cell axon guidance (GO:0031290)3.28000488
76gonadal mesoderm development (GO:0007506)3.27735159
77positive regulation of dendritic spine development (GO:0060999)3.25073405
78cell communication by electrical coupling (GO:0010644)3.20368238
79learning (GO:0007612)3.19912650
80regulation of vesicle fusion (GO:0031338)3.19631585
81G-protein coupled glutamate receptor signaling pathway (GO:0007216)3.19539504
82neurotransmitter transport (GO:0006836)3.17656785
83negative regulation of synaptic transmission, glutamatergic (GO:0051967)3.17467223
84positive regulation of potassium ion transmembrane transporter activity (GO:1901018)3.17355190
85membrane depolarization (GO:0051899)3.15680705
86synapse assembly (GO:0007416)3.15148746
87central nervous system neuron axonogenesis (GO:0021955)3.15142285
88nonmotile primary cilium assembly (GO:0035058)3.14700179
89regulation of glutamate secretion (GO:0014048)3.14632976
90negative regulation of amino acid transport (GO:0051956)3.14451582
91synaptic vesicle endocytosis (GO:0048488)3.14269785
92regulation of dendritic spine development (GO:0060998)3.13960984
93neuromuscular process controlling balance (GO:0050885)3.12246164
94establishment of nucleus localization (GO:0040023)3.11039436
95dendritic spine organization (GO:0097061)3.09516424
96neuronal ion channel clustering (GO:0045161)3.07242691
97membrane depolarization during action potential (GO:0086010)3.04834501
98cerebellar granule cell differentiation (GO:0021707)3.03645580
99regulation of neurotransmitter secretion (GO:0046928)3.02643469
100cerebral cortex cell migration (GO:0021795)3.01979097
101positive regulation of synapse assembly (GO:0051965)3.01952119
102cerebellar Purkinje cell differentiation (GO:0021702)3.01835373
103G-protein coupled acetylcholine receptor signaling pathway (GO:0007213)2.99859824
104epithelial cilium movement (GO:0003351)2.97893148
105cell communication by electrical coupling involved in cardiac conduction (GO:0086064)2.97859564
106regulation of synaptic transmission (GO:0050804)2.96336496
107epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)2.95976501
108cellular potassium ion homeostasis (GO:0030007)2.95881014
109regulation of collateral sprouting (GO:0048670)2.95494730
110regulation of axon guidance (GO:1902667)2.94710137
111regulation of synaptic transmission, GABAergic (GO:0032228)2.94537466
112regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)2.94249599
113regulation of respiratory system process (GO:0044065)2.94074057
114dendrite development (GO:0016358)2.93998275
115intraciliary transport (GO:0042073)2.93375912
116regulation of neurotransmitter levels (GO:0001505)2.93251506
117synaptic transmission (GO:0007268)2.92723354
118auditory behavior (GO:0031223)2.92258637
119atrial cardiac muscle cell action potential (GO:0086014)2.83690616
120negative regulation of calcium ion-dependent exocytosis (GO:0045955)2.80901970
121regulation of non-canonical Wnt signaling pathway (GO:2000050)2.80202948
122sympathetic nervous system development (GO:0048485)2.79817320
123establishment of mitochondrion localization (GO:0051654)2.79256606
124positive regulation of protein homodimerization activity (GO:0090073)2.79005744
125regulation of synapse assembly (GO:0051963)2.73114853
126neural tube formation (GO:0001841)2.71954158
127olfactory bulb development (GO:0021772)2.71368251
128mechanosensory behavior (GO:0007638)2.70868183
129spinal cord development (GO:0021510)2.69694383
130cilium movement (GO:0003341)2.66562719
131behavioral response to ethanol (GO:0048149)2.66345693
132negative chemotaxis (GO:0050919)2.65389370
133cilium organization (GO:0044782)2.64845180
134cilium assembly (GO:0042384)2.64675971
135short-term memory (GO:0007614)2.63139131
136negative regulation of axon guidance (GO:1902668)2.58960446
137regulation of timing of cell differentiation (GO:0048505)2.58676591
138negative regulation of glial cell differentiation (GO:0045686)2.56442661
139negative regulation of cytosolic calcium ion concentration (GO:0051481)2.55581929
140limb development (GO:0060173)2.55446335
141appendage development (GO:0048736)2.55446335
142regulation of sarcomere organization (GO:0060297)2.55055677
143calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules (GO:0016339)2.55018103
144regulation of axon extension involved in axon guidance (GO:0048841)2.55010715
145neuron migration (GO:0001764)2.52975205
146hippocampus development (GO:0021766)2.52698835
147positive regulation of dendrite morphogenesis (GO:0050775)2.52637277
148regulation of development, heterochronic (GO:0040034)2.51743613
149C4-dicarboxylate transport (GO:0015740)2.49964038
150synaptic transmission, cholinergic (GO:0007271)2.49736376
151inner ear receptor stereocilium organization (GO:0060122)2.49714624
152cilium morphogenesis (GO:0060271)2.47162704
153ephrin receptor signaling pathway (GO:0048013)2.46709595
154regulation of Wnt signaling pathway, planar cell polarity pathway (GO:2000095)2.45888135
155negative regulation of mast cell activation (GO:0033004)2.44593125
156negative regulation of axon extension (GO:0030517)2.43597528
157axoneme assembly (GO:0035082)2.41129616
158neuron fate determination (GO:0048664)2.39985210
159heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules (GO:0007157)2.39601203
160microtubule anchoring (GO:0034453)2.39514721
161protein polyglutamylation (GO:0018095)2.39304433
162detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)2.39046010
163regulation of cilium movement (GO:0003352)2.37068146
164regulation of action potential (GO:0098900)2.36430772
165telencephalon cell migration (GO:0022029)2.35700332
166otic vesicle formation (GO:0030916)2.35310756
167smoothened signaling pathway (GO:0007224)2.35229380
168cranial nerve morphogenesis (GO:0021602)2.35145477
169cilium or flagellum-dependent cell motility (GO:0001539)2.34808457

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human7.01049857
2GBX2_23144817_ChIP-Seq_PC3_Human4.00594052
3* JARID2_20064375_ChIP-Seq_MESCs_Mouse3.11130996
4* SUZ12_18692474_ChIP-Seq_MESCs_Mouse3.02967805
5* SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.89972683
6RBPJ_22232070_ChIP-Seq_NCS_Mouse2.70391434
7EZH2_27304074_Chip-Seq_ESCs_Mouse2.66420292
8JARID2_20075857_ChIP-Seq_MESCs_Mouse2.64631066
9RNF2_18974828_ChIP-Seq_MESCs_Mouse2.63291502
10EZH2_18974828_ChIP-Seq_MESCs_Mouse2.63291502
11* SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.58708595
12SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.55845967
13REST_21632747_ChIP-Seq_MESCs_Mouse2.53101140
14SALL1_21062744_ChIP-ChIP_HESCs_Human2.52855214
15ZFP322A_24550733_ChIP-Seq_MESCs_Mouse2.43243779
16SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.41965807
17EED_16625203_ChIP-ChIP_MESCs_Mouse2.37833705
18* MTF2_20144788_ChIP-Seq_MESCs_Mouse2.32050065
19* SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.29747532
20EZH2_27294783_Chip-Seq_ESCs_Mouse2.22862113
21RNF2_27304074_Chip-Seq_ESCs_Mouse2.20061423
22CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons2.19790688
23* DROSHA_22980978_ChIP-Seq_HELA_Human2.17004839
24VDR_22108803_ChIP-Seq_LS180_Human2.15954278
25* SUZ12_27294783_Chip-Seq_ESCs_Mouse2.15563346
26GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.12415800
27HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.09525162
28* RARB_27405468_Chip-Seq_BRAIN_Mouse2.07904777
29EWS_26573619_Chip-Seq_HEK293_Human2.05753247
30REST_18959480_ChIP-ChIP_MESCs_Mouse1.98664913
31CTBP2_25329375_ChIP-Seq_LNCAP_Human1.98071510
32IKZF1_21737484_ChIP-ChIP_HCT116_Human1.91873165
33CTBP1_25329375_ChIP-Seq_LNCAP_Human1.88086241
34AR_21572438_ChIP-Seq_LNCaP_Human1.86065027
35TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.82727046
36NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.78648276
37ZFP57_27257070_Chip-Seq_ESCs_Mouse1.77916062
38* SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.76355648
39ZNF274_21170338_ChIP-Seq_K562_Hela1.75100536
40CBX2_27304074_Chip-Seq_ESCs_Mouse1.74516653
41FLI1_27457419_Chip-Seq_LIVER_Mouse1.70566500
42* SMAD4_21799915_ChIP-Seq_A2780_Human1.70316226
43PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.70123076
44TAF15_26573619_Chip-Seq_HEK293_Human1.68505181
45MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.67494835
46P300_19829295_ChIP-Seq_ESCs_Human1.61544196
47PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.60367899
48RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.54046076
49CBP_20019798_ChIP-Seq_JUKART_Human1.49259592
50IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.49259592
51PCGF2_27294783_Chip-Seq_ESCs_Mouse1.48398713
52MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.46319387
53EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.46224714
54SMAD3_21741376_ChIP-Seq_EPCs_Human1.45465828
55GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.42356998
56SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.41214112
57IGF1R_20145208_ChIP-Seq_DFB_Human1.36771831
58BMI1_23680149_ChIP-Seq_NPCS_Mouse1.36746547
59FUS_26573619_Chip-Seq_HEK293_Human1.36701310
60AR_25329375_ChIP-Seq_VCAP_Human1.34665834
61SOX2_21211035_ChIP-Seq_LN229_Gbm1.33318367
62RING1B_27294783_Chip-Seq_ESCs_Mouse1.33273719
63TOP2B_26459242_ChIP-Seq_MCF-7_Human1.32685235
64BCAT_22108803_ChIP-Seq_LS180_Human1.30321092
65OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.27782561
66RNF2_27304074_Chip-Seq_NSC_Mouse1.26794902
67ERG_21242973_ChIP-ChIP_JURKAT_Human1.24623096
68SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.24332461
69SUZ12_27294783_Chip-Seq_NPCs_Mouse1.24124566
70POU5F1_16153702_ChIP-ChIP_HESCs_Human1.23765984
71PIAS1_25552417_ChIP-Seq_VCAP_Human1.23567011
72* MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.23529357
73NR3C1_23031785_ChIP-Seq_PC12_Mouse1.23457169
74* STAT3_23295773_ChIP-Seq_U87_Human1.22517667
75PCGF2_27294783_Chip-Seq_NPCs_Mouse1.21995490
76RING1B_27294783_Chip-Seq_NPCs_Mouse1.21618444
77KLF5_20875108_ChIP-Seq_MESCs_Mouse1.19945560
78EZH2_27294783_Chip-Seq_NPCs_Mouse1.19684753
79POU3F2_20337985_ChIP-ChIP_501MEL_Human1.19217202
80AR_19668381_ChIP-Seq_PC3_Human1.19149872
81KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.18825127
82MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.17889289
83SMAD_19615063_ChIP-ChIP_OVARY_Human1.17770006
84CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.17701147
85TCF4_22108803_ChIP-Seq_LS180_Human1.17562024
86EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.16398465
87ARNT_22903824_ChIP-Seq_MCF-7_Human1.15529650
88ZNF217_24962896_ChIP-Seq_MCF-7_Human1.14920767
89YAP1_20516196_ChIP-Seq_MESCs_Mouse1.14894375
90TP63_19390658_ChIP-ChIP_HaCaT_Human1.12587175
91CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.12366768
92FLI1_21867929_ChIP-Seq_TH2_Mouse1.12349120
93TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.11704150
94* TCF4_23295773_ChIP-Seq_U87_Human1.11606122
95AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.10303891
96AHR_22903824_ChIP-Seq_MCF-7_Human1.09357099
97LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.08252605
98VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.07938713
99* P53_22387025_ChIP-Seq_ESCs_Mouse1.07490115
100NFE2_27457419_Chip-Seq_LIVER_Mouse1.07165145
101TAL1_26923725_Chip-Seq_HPCs_Mouse1.05995397
102* WT1_25993318_ChIP-Seq_PODOCYTE_Human1.05692250
103NR3C1_21868756_ChIP-Seq_MCF10A_Human1.05670368
104RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.05547862
105TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse1.05152076
106JUN_21703547_ChIP-Seq_K562_Human1.04606874
107GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.03557946
108* E2F1_18555785_Chip-Seq_ESCs_Mouse1.03139645
109RUNX2_22187159_ChIP-Seq_PCA_Human1.03002072
110HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.02355586
111CEBPB_26923725_Chip-Seq_MESODERM_Mouse1.01952249
112* TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.01762195
113* POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.01762195
114IRF1_19129219_ChIP-ChIP_H3396_Human1.01541975
115CDX2_19796622_ChIP-Seq_MESCs_Mouse1.00831652
116P53_22127205_ChIP-Seq_FIBROBLAST_Human1.00750634
117* TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse0.99409228
118* TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse0.98874946
119* MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.98539230
120TP53_18474530_ChIP-ChIP_U2OS_Human0.98245099
121* PRDM14_20953172_ChIP-Seq_ESCs_Human0.97844293
122TP53_16413492_ChIP-PET_HCT116_Human0.97280222
123UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human0.95926655
124* NANOG_18555785_Chip-Seq_ESCs_Mouse0.95567557
125ER_23166858_ChIP-Seq_MCF-7_Human0.94936428
126SMAD3_21741376_ChIP-Seq_ESCs_Human0.94363878
127WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse0.92822062
128TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.92664490
129DNAJC2_21179169_ChIP-ChIP_NT2_Human0.91368248
130* SMAD3_21741376_ChIP-Seq_HESCs_Human0.90609317
131* SMAD4_21741376_ChIP-Seq_HESCs_Human0.90350596
132SOX9_26525672_Chip-Seq_HEART_Mouse0.87510962
133TCF3_18467660_ChIP-ChIP_MESCs_Mouse0.85089890

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity6.90933208
2MP0003880_abnormal_central_pattern5.06629474
3MP0003635_abnormal_synaptic_transmissio4.11509102
4MP0009745_abnormal_behavioral_response3.42773117
5MP0002063_abnormal_learning/memory/cond3.39083290
6MP0004270_analgesia3.37705874
7MP0002064_seizures3.04526966
8MP0002822_catalepsy2.83148322
9MP0002572_abnormal_emotion/affect_behav2.79818921
10MP0009046_muscle_twitch2.76264406
11MP0005423_abnormal_somatic_nervous2.76057019
12MP0002735_abnormal_chemical_nociception2.75584720
13MP0001968_abnormal_touch/_nociception2.67539393
14MP0002734_abnormal_mechanical_nocicepti2.46146430
15MP0000778_abnormal_nervous_system2.42891339
16MP0002272_abnormal_nervous_system2.34506559
17MP0001486_abnormal_startle_reflex2.34482218
18MP0000566_synostosis2.27993779
19MP0002736_abnormal_nociception_after2.16057358
20MP0002184_abnormal_innervation2.11636958
21MP0003787_abnormal_imprinting2.02829872
22MP0001440_abnormal_grooming_behavior2.02256212
23MP0001501_abnormal_sleep_pattern1.91621114
24MP0004858_abnormal_nervous_system1.91339707
25MP0002733_abnormal_thermal_nociception1.89374427
26MP0002067_abnormal_sensory_capabilities1.89159460
27MP0004811_abnormal_neuron_physiology1.84336771
28MP0003136_yellow_coat_color1.81781378
29MP0001970_abnormal_pain_threshold1.77918180
30MP0006276_abnormal_autonomic_nervous1.77021367
31MP0002557_abnormal_social/conspecific_i1.76748745
32MP0000955_abnormal_spinal_cord1.71072056
33MP0009780_abnormal_chondrocyte_physiolo1.70418821
34MP0005645_abnormal_hypothalamus_physiol1.61364265
35MP0008569_lethality_at_weaning1.58489261
36MP0001188_hyperpigmentation1.55121725
37MP0002882_abnormal_neuron_morphology1.53057052
38MP0004924_abnormal_behavior1.52079154
39MP0005386_behavior/neurological_phenoty1.52079154
40MP0003937_abnormal_limbs/digits/tail_de1.51938065
41MP0005253_abnormal_eye_physiology1.51311047
42MP0006072_abnormal_retinal_apoptosis1.51286374
43MP0003890_abnormal_embryonic-extraembry1.48993337
44MP0002938_white_spotting1.48282349
45MP0004885_abnormal_endolymph1.43647540
46MP0000569_abnormal_digit_pigmentation1.43480046
47MP0008789_abnormal_olfactory_epithelium1.42881685
48MP0003329_amyloid_beta_deposits1.42426384
49MP0003122_maternal_imprinting1.42395595
50MP0003879_abnormal_hair_cell1.39071972
51MP0005646_abnormal_pituitary_gland1.38414520
52MP0002066_abnormal_motor_capabilities/c1.37199319
53MP0003283_abnormal_digestive_organ1.34384255
54MP0002653_abnormal_ependyma_morphology1.33540380
55MP0004142_abnormal_muscle_tone1.32362374
56MP0005367_renal/urinary_system_phenotyp1.31877077
57MP0000516_abnormal_urinary_system1.31877077
58MP0002152_abnormal_brain_morphology1.27191012
59MP0002233_abnormal_nose_morphology1.26578644
60MP0001293_anophthalmia1.22822217
61MP0001529_abnormal_vocalization1.21504281
62MP0001984_abnormal_olfaction1.21465002
63MP0003755_abnormal_palate_morphology1.19882352
64MP0003195_calcinosis1.19707313
65MP0002909_abnormal_adrenal_gland1.17186607
66MP0005195_abnormal_posterior_eye1.16772487
67MP0000647_abnormal_sebaceous_gland1.14616931
68MP0000049_abnormal_middle_ear1.13835104
69MP0003633_abnormal_nervous_system1.13667431
70MP0006292_abnormal_olfactory_placode1.12582488
71MP0001905_abnormal_dopamine_level1.12461112
72MP0000427_abnormal_hair_cycle1.11931934
73MP0001502_abnormal_circadian_rhythm1.11750234
74MP0002282_abnormal_trachea_morphology1.11629865
75MP0004133_heterotaxia1.10787364
76MP0005391_vision/eye_phenotype1.08932514
77MP0003631_nervous_system_phenotype1.06404451
78MP0003942_abnormal_urinary_system1.00152490
79MP0002249_abnormal_larynx_morphology0.99012983
80MP0000579_abnormal_nail_morphology0.98447702
81MP0000383_abnormal_hair_follicle0.97481423
82MP0001177_atelectasis0.95571689
83MP0010386_abnormal_urinary_bladder0.95437595
84MP0002069_abnormal_eating/drinking_beha0.93667676
85MP0004742_abnormal_vestibular_system0.92252265
86MP0002752_abnormal_somatic_nervous0.91883483
87MP0001286_abnormal_eye_development0.91451483
88MP0000631_abnormal_neuroendocrine_gland0.91014250
89MP0003861_abnormal_nervous_system0.89711027
90MP0003011_delayed_dark_adaptation0.88843450
91MP0003632_abnormal_nervous_system0.88005111
92MP0003385_abnormal_body_wall0.87822752
93MP0003935_abnormal_craniofacial_develop0.87627054
94MP0005394_taste/olfaction_phenotype0.87154264
95MP0005499_abnormal_olfactory_system0.87154264
96MP0005171_absent_coat_pigmentation0.85395634
97MP0002876_abnormal_thyroid_physiology0.84762668
98MP0001963_abnormal_hearing_physiology0.84319102
99MP0003938_abnormal_ear_development0.83763809
100MP0003123_paternal_imprinting0.83006271
101MP0002234_abnormal_pharynx_morphology0.82352841
102MP0003121_genomic_imprinting0.81769388
103MP0001324_abnormal_eye_pigmentation0.81649955
104MP0005248_abnormal_Harderian_gland0.81389044
105MP0002102_abnormal_ear_morphology0.81132666
106MP0000372_irregular_coat_pigmentation0.81032333
107MP0004085_abnormal_heartbeat0.80944956
108MP0002697_abnormal_eye_size0.80775058
109MP0003698_abnormal_male_reproductive0.80642808
110MP0005409_darkened_coat_color0.78661365
111MP0003567_abnormal_fetal_cardiomyocyte0.78616761
112MP0002081_perinatal_lethality0.77484195
113MP0000026_abnormal_inner_ear0.77343598
114MP0000534_abnormal_ureter_morphology0.77272019
115MP0003634_abnormal_glial_cell0.76970711
116MP0004145_abnormal_muscle_electrophysio0.74969171
117MP0002638_abnormal_pupillary_reflex0.71570512
118MP0004215_abnormal_myocardial_fiber0.71351202
119MP0002837_dystrophic_cardiac_calcinosis0.70990077
120MP0002229_neurodegeneration0.70825233
121MP0000751_myopathy0.70196784
122MP0002751_abnormal_autonomic_nervous0.68195477
123MP0008874_decreased_physiological_sensi0.67969865
124MP0008872_abnormal_physiological_respon0.66455240
125MP0005551_abnormal_eye_electrophysiolog0.64016130
126MP0001485_abnormal_pinna_reflex0.60046189
127MP0004510_myositis0.59494657
128MP0003137_abnormal_impulse_conducting0.59337907
129MP0002082_postnatal_lethality0.59302690
130MP0010770_preweaning_lethality0.59302690
131MP0010769_abnormal_survival0.58954470
132MP0005187_abnormal_penis_morphology0.58616704
133MP0001299_abnormal_eye_distance/0.58482822
134MP0008961_abnormal_basal_metabolism0.57335028
135MP0004484_altered_response_of0.56970585
136MP0001943_abnormal_respiration0.56454472
137MP0000537_abnormal_urethra_morphology0.55997900
138MP0008877_abnormal_DNA_methylation0.55327751
139MP0003119_abnormal_digestive_system0.55224974

Predicted human phenotypes

RankGene SetZ-score
1Focal motor seizures (HP:0011153)8.25677566
2Myokymia (HP:0002411)6.27060872
3Focal seizures (HP:0007359)5.62496300
4Epileptic encephalopathy (HP:0200134)4.63068383
5Febrile seizures (HP:0002373)4.56240439
6Progressive cerebellar ataxia (HP:0002073)4.52060496
7Visual hallucinations (HP:0002367)4.49656724
8Atonic seizures (HP:0010819)4.32738392
9Absence seizures (HP:0002121)3.88351387
10Hyperventilation (HP:0002883)3.84239954
11Dialeptic seizures (HP:0011146)3.78087303
12Generalized tonic-clonic seizures (HP:0002069)3.71988182
13True hermaphroditism (HP:0010459)3.57102085
14Broad-based gait (HP:0002136)3.54041173
15Drooling (HP:0002307)3.37740255
16Excessive salivation (HP:0003781)3.37740255
17Pancreatic cysts (HP:0001737)3.36497663
18Pancreatic fibrosis (HP:0100732)3.27940411
19Action tremor (HP:0002345)3.23081724
20Impaired vibration sensation in the lower limbs (HP:0002166)3.22958176
21Mutism (HP:0002300)3.21684862
22Gaze-evoked nystagmus (HP:0000640)3.01995313
23Genetic anticipation (HP:0003743)3.01723747
24Molar tooth sign on MRI (HP:0002419)2.98867453
25Abnormality of midbrain morphology (HP:0002418)2.98867453
26Supranuclear gaze palsy (HP:0000605)2.96113151
27Nephronophthisis (HP:0000090)2.90911438
28Amblyopia (HP:0000646)2.90599673
29Dysdiadochokinesis (HP:0002075)2.81767765
30Poor eye contact (HP:0000817)2.72754572
31Hemiparesis (HP:0001269)2.72218571
32Truncal ataxia (HP:0002078)2.72155193
33Medial flaring of the eyebrow (HP:0010747)2.71887694
34Chronic hepatic failure (HP:0100626)2.70317628
35Genital tract atresia (HP:0001827)2.68877601
36Progressive inability to walk (HP:0002505)2.65927567
37Urinary bladder sphincter dysfunction (HP:0002839)2.65692557
38Ankle clonus (HP:0011448)2.65374046
39Abnormal eating behavior (HP:0100738)2.65056385
40Epileptiform EEG discharges (HP:0011182)2.64579237
41Diplopia (HP:0000651)2.64460110
42Abnormality of binocular vision (HP:0011514)2.64460110
43Dysmetria (HP:0001310)2.64270832
44Vaginal atresia (HP:0000148)2.63131801
45Abnormality of the lower motor neuron (HP:0002366)2.62633668
46Absent speech (HP:0001344)2.56207247
47Depression (HP:0000716)2.55113164
48Fetal akinesia sequence (HP:0001989)2.53161352
49Volvulus (HP:0002580)2.50307110
50Impaired social interactions (HP:0000735)2.49912385
51Abnormal social behavior (HP:0012433)2.49912385
52Abnormality of the corticospinal tract (HP:0002492)2.49752635
53Congenital primary aphakia (HP:0007707)2.45289919
54Hepatoblastoma (HP:0002884)2.44494699
55EEG with generalized epileptiform discharges (HP:0011198)2.43775931
56Abnormality of the renal medulla (HP:0100957)2.43312892
57Urinary urgency (HP:0000012)2.42882695
58Postaxial foot polydactyly (HP:0001830)2.41875274
59Anxiety (HP:0000739)2.37193674
60Postaxial hand polydactyly (HP:0001162)2.35202495
61Polyphagia (HP:0002591)2.34340672
62Type II lissencephaly (HP:0007260)2.33424414
63Hypsarrhythmia (HP:0002521)2.32961468
64Scanning speech (HP:0002168)2.31106789
65Intestinal atresia (HP:0011100)2.31047369
66Postural instability (HP:0002172)2.29462271
67Stereotypic behavior (HP:0000733)2.29404055
68Agitation (HP:0000713)2.27134130
69Aplasia/Hypoplasia of the tongue (HP:0010295)2.24863510
70Protruding tongue (HP:0010808)2.23816265
71Exotropia (HP:0000577)2.21804668
72Spastic gait (HP:0002064)2.21710213
73Cystic liver disease (HP:0006706)2.21461023
74Optic nerve hypoplasia (HP:0000609)2.20614565
75Nephrogenic diabetes insipidus (HP:0009806)2.20490147
76Akinesia (HP:0002304)2.20436984
77Aplasia/Hypoplasia of the tibia (HP:0005772)2.20087488
78Papilledema (HP:0001085)2.19197956
79Torticollis (HP:0000473)2.18241977
80Amyotrophic lateral sclerosis (HP:0007354)2.16235028
81Sclerocornea (HP:0000647)2.15942770
82Abnormality of salivation (HP:0100755)2.15803994
83Focal dystonia (HP:0004373)2.14132139
84Renal hypoplasia (HP:0000089)2.13810855
85Cerebral inclusion bodies (HP:0100314)2.12458135
86Abnormality of the labia minora (HP:0012880)2.11824692
87Termporal pattern (HP:0011008)2.11290516
88Insidious onset (HP:0003587)2.11290516
89Lower limb asymmetry (HP:0100559)2.10717879
90Impaired smooth pursuit (HP:0007772)2.09150670
91Obstructive sleep apnea (HP:0002870)2.08742311
92Anencephaly (HP:0002323)2.08611292
93Inability to walk (HP:0002540)2.08489227
94Inappropriate behavior (HP:0000719)2.07455216
95Limb dystonia (HP:0002451)2.07120325
96Blue irides (HP:0000635)2.06662106
97Midline defect of the nose (HP:0004122)2.05712769
98Colon cancer (HP:0003003)2.05664848
99Septo-optic dysplasia (HP:0100842)2.05639405
100Renal cortical cysts (HP:0000803)2.05299921
101Megalencephaly (HP:0001355)2.03254764
102Decreased number of large peripheral myelinated nerve fibers (HP:0003387)2.03060417
103Pointed chin (HP:0000307)2.02322836
104Occipital encephalocele (HP:0002085)2.02192485
105Tented upper lip vermilion (HP:0010804)2.01094735
106Cupped ear (HP:0000378)2.00415295
107Cerebellar dysplasia (HP:0007033)1.99931501
108Abnormality of the renal cortex (HP:0011035)1.99885055
109Pendular nystagmus (HP:0012043)1.99583096
110Preaxial foot polydactyly (HP:0001841)1.99472269
111Hemiplegia (HP:0002301)1.98647841
112Cutaneous syndactyly (HP:0012725)1.98424679
113Abnormality of ocular smooth pursuit (HP:0000617)1.98314888
114Bradykinesia (HP:0002067)1.97977690
115Incomplete penetrance (HP:0003829)1.96524359
116Bifid tongue (HP:0010297)1.96254994
117Neurofibrillary tangles (HP:0002185)1.95850014
118Impaired vibratory sensation (HP:0002495)1.94447207
119Narrow forehead (HP:0000341)1.93537261
120Epidermoid cyst (HP:0200040)1.92601807
121Lower limb muscle weakness (HP:0007340)1.91786152
122Gastrointestinal atresia (HP:0002589)1.91717031
123Aplasia/Hypoplasia of the sternum (HP:0006714)1.90024092
124Preaxial hand polydactyly (HP:0001177)1.89736024
125Fair hair (HP:0002286)1.89355390
126Generalized myoclonic seizures (HP:0002123)1.88953361
127Anosmia (HP:0000458)1.88394901
128Lissencephaly (HP:0001339)1.88176465
129Stomach cancer (HP:0012126)1.88059286
130Intention tremor (HP:0002080)1.86887526
131Retinal dysplasia (HP:0007973)1.86325605
132Thickened helices (HP:0000391)1.85574564
133Narrow nasal bridge (HP:0000446)1.85199558
134Specific learning disability (HP:0001328)1.84892478
135Abnormal ciliary motility (HP:0012262)1.84553036
136Long nose (HP:0003189)1.84523796
137Short tibia (HP:0005736)1.84381822
138Tubulointerstitial nephritis (HP:0001970)1.81968084
139Anophthalmia (HP:0000528)1.81549196
140Pachygyria (HP:0001302)1.81547360
141Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.81302930
142Widely spaced teeth (HP:0000687)1.79560382
143Pheochromocytoma (HP:0002666)1.78139503
144Conical tooth (HP:0000698)1.78122123
145Poor coordination (HP:0002370)1.77475591
146Hypothermia (HP:0002045)1.76846757
147Hyperglycinemia (HP:0002154)1.76786249
148Status epilepticus (HP:0002133)1.76330456
149Gastroesophageal reflux (HP:0002020)1.75932159
150Craniofacial dystonia (HP:0012179)1.75820634
151Alacrima (HP:0000522)1.75551196
152Aplasia/Hypoplasia of the pubic bone (HP:0009104)1.74930833
153Aplasia/Hypoplasia of the brainstem (HP:0007362)1.74424164
154Hypoplasia of the brainstem (HP:0002365)1.74424164
155Abnormal respiratory motile cilium physiology (HP:0012261)1.74194964
156Male pseudohermaphroditism (HP:0000037)1.74163578
157Sleep apnea (HP:0010535)1.73362999
158Neoplasm of the adrenal cortex (HP:0100641)1.73124767
159Increased corneal curvature (HP:0100692)1.71955543
160Keratoconus (HP:0000563)1.71955543
161Congenital stationary night blindness (HP:0007642)1.71910081
162Respiratory insufficiency due to defective ciliary clearance (HP:0200073)1.71825858
163Absent eyebrow (HP:0002223)1.71804092
164Abnormality of the pubic bones (HP:0003172)1.71699146
165Abnormal respiratory epithelium morphology (HP:0012253)1.71473162
166Abnormal respiratory motile cilium morphology (HP:0005938)1.71473162
167Gait imbalance (HP:0002141)1.70933367
168Esotropia (HP:0000565)1.70420280
169Intellectual disability, moderate (HP:0002342)1.69625115
170Autism (HP:0000717)1.69527451
171Aqueductal stenosis (HP:0002410)1.67565053
172Oligodactyly (hands) (HP:0001180)1.67390987
173Prominent nasal bridge (HP:0000426)1.67083079
174Gait ataxia (HP:0002066)1.66702995
175Decreased lacrimation (HP:0000633)1.66599887
176Cutaneous finger syndactyly (HP:0010554)1.65485574
177Micropenis (HP:0000054)1.65454083
178Neoplasm of the oral cavity (HP:0100649)1.64443377

Predicted kinase interactions (KEA)

RankGene SetZ-score
1NTRK35.70806023
2EPHA44.60032455
3MARK14.41856086
4FRK3.42654300
5MAP3K93.22892234
6MAP3K42.99409517
7TNIK2.90487209
8MAP2K72.75157409
9CASK2.71967647
10MINK12.50301524
11CCNB12.33249580
12MAP4K22.32503826
13NTRK22.24687777
14KSR11.94152646
15DAPK21.79402690
16MAPK131.78567314
17BMPR1B1.76213893
18PAK61.73231002
19KSR21.69863565
20STK38L1.68511404
21EPHA31.63774644
22MAP2K41.59402866
23PINK11.59244055
24ZAK1.56875553
25FGFR21.56708415
26PLK21.54575167
27PRKD31.52362052
28CDK51.48693079
29PRPF4B1.47078948
30DAPK11.41086319
31TRIM281.40912871
32CAMKK11.39955032
33PNCK1.38936708
34NUAK11.38923139
35EPHB21.34291289
36MAP3K121.33885783
37FES1.33523278
38PRKCG1.29606219
39SIK21.27962629
40CSNK1G11.20853905
41CSNK1G31.14107605
42CAMK2A1.13733582
43PHKG21.10806548
44PHKG11.10806548
45LATS11.10563336
46STK381.09482840
47MKNK21.07385702
48CSNK1A1L1.05444446
49WNK41.02919327
50CAMK2B1.02196134
51GRK50.99749149
52LATS20.96982841
53INSRR0.95617376
54PAK30.94039976
55ERBB30.91861255
56NTRK10.91454897
57DYRK30.91019345
58SGK20.90713368
59WEE10.90712940
60MAP3K130.90257900
61SGK4940.89672534
62SGK2230.89672534
63TYRO30.89537030
64MKNK10.87334192
65CSNK1G20.84062332
66CAMK10.83951588
67UHMK10.80383786
68MAP3K20.80342310
69ADRBK20.80281850
70GRK10.79908796
71CDK180.79088024
72DYRK1A0.77911474
73AKT30.77751266
74SGK10.76921654
75MAPK150.76178892
76CDK150.75861573
77ARAF0.74567833
78PLK40.74224331
79TAOK10.74064554
80MAP3K60.73878718
81CDK140.73661867
82BRSK20.73111758
83STK110.72282107
84CAMK1G0.72027321
85STK390.71665672
86PTK2B0.71533154
87MARK20.70668510
88FER0.69938293
89VRK10.69683632
90RAF10.68430278
91SRPK10.67963258
92PLK30.66334099
93PRKCE0.64640048
94CDK11A0.63979569
95DYRK20.63833092
96FGR0.62736703
97PRKCZ0.62175308
98PRKCH0.60505183
99SGK30.60476319
100RET0.58510251
101LMTK20.58081036
102RIPK40.56661496
103NME10.56578111
104CAMKK20.56322897
105ALK0.55888216
106CDK190.55599599
107PKN10.54023765
108TLK10.52970685
109TGFBR10.52571839
110CSNK1D0.50815087
111EIF2AK30.49003723
112RPS6KA30.47914379
113MUSK0.47002994
114GRK70.45851841
115ERBB20.45787401
116CAMK2D0.45300734
117OXSR10.45216809
118FYN0.44866937
119WNK30.44517653
120ATM0.43880918
121CSNK1A10.43850702
122BCR0.43155905
123CDC42BPA0.43154030
124PDK10.42096089
125OBSCN0.41545004
126ATR0.41414011
127YES10.41187632
128BMPR20.40994725
129BRD40.40811461
130BRAF0.40547035
131CAMK40.38583313
132STK30.38554993
133NEK60.38080187
134CDK30.37930875
135CAMK2G0.37775633
136SIK30.37049290
137RPS6KA20.36561902
138STK160.36178732
139PRKCB0.36153319
140MAPK100.35495803
141ADRBK10.35305237
142PRKG10.34256375
143CAMK1D0.34044237
144PRKACA0.33089952
145PRKDC0.33052878
146RPS6KA40.32498384
147MAP2K10.32060859
148PLK10.31863458
149PDPK10.31630787
150MAP3K10.30717973
151CSNK1E0.30249811
152CHEK20.29045522
153ROCK10.27399594

Predicted pathways (KEGG)

RankGene SetZ-score
1Nicotine addiction_Homo sapiens_hsa050334.25381017
2Synthesis and degradation of ketone bodies_Homo sapiens_hsa000723.41951341
3Synaptic vesicle cycle_Homo sapiens_hsa047212.99300552
4Steroid biosynthesis_Homo sapiens_hsa001002.87346210
5Circadian entrainment_Homo sapiens_hsa047132.87123695
6Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.81414227
7GABAergic synapse_Homo sapiens_hsa047272.76576620
8Long-term potentiation_Homo sapiens_hsa047202.73026708
9Glutamatergic synapse_Homo sapiens_hsa047242.70134069
10Butanoate metabolism_Homo sapiens_hsa006502.57167546
11Morphine addiction_Homo sapiens_hsa050322.55190021
12Olfactory transduction_Homo sapiens_hsa047402.45179753
13Amphetamine addiction_Homo sapiens_hsa050312.40855589
14Dopaminergic synapse_Homo sapiens_hsa047282.20645220
15Propanoate metabolism_Homo sapiens_hsa006402.03428405
16Cholinergic synapse_Homo sapiens_hsa047251.99650962
17Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.98569854
18Salivary secretion_Homo sapiens_hsa049701.96709042
19Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.94865009
20Serotonergic synapse_Homo sapiens_hsa047261.85788604
21Insulin secretion_Homo sapiens_hsa049111.85237989
22Aldosterone synthesis and secretion_Homo sapiens_hsa049251.83653123
23Long-term depression_Homo sapiens_hsa047301.83334896
24Taste transduction_Homo sapiens_hsa047421.83130645
25Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.76483289
26Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.71562686
27Axon guidance_Homo sapiens_hsa043601.69363627
28Gastric acid secretion_Homo sapiens_hsa049711.65691789
29Calcium signaling pathway_Homo sapiens_hsa040201.64937954
30Oxytocin signaling pathway_Homo sapiens_hsa049211.60528396
31Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.58064382
32Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.56300285
33Renin secretion_Homo sapiens_hsa049241.55757502
34Cocaine addiction_Homo sapiens_hsa050301.49538017
35Protein export_Homo sapiens_hsa030601.49479121
36Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.43719214
37Primary bile acid biosynthesis_Homo sapiens_hsa001201.42554576
38GnRH signaling pathway_Homo sapiens_hsa049121.41813807
39Collecting duct acid secretion_Homo sapiens_hsa049661.38629362
40Fanconi anemia pathway_Homo sapiens_hsa034601.34359826
41Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.32878892
42Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.32584129
43cAMP signaling pathway_Homo sapiens_hsa040241.32256169
44Maturity onset diabetes of the young_Homo sapiens_hsa049501.30415160
45Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.30263042
46Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.30043984
47Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.30026178
48Gap junction_Homo sapiens_hsa045401.29497139
49Type II diabetes mellitus_Homo sapiens_hsa049301.28987261
50Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.25410254
51Basal transcription factors_Homo sapiens_hsa030221.20805939
52ErbB signaling pathway_Homo sapiens_hsa040121.20005557
53Estrogen signaling pathway_Homo sapiens_hsa049151.18706619
54alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.18068104
55Glioma_Homo sapiens_hsa052141.16903881
56Melanogenesis_Homo sapiens_hsa049161.16210051
57Nitrogen metabolism_Homo sapiens_hsa009101.15918430
58Linoleic acid metabolism_Homo sapiens_hsa005911.11893549
59Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.10611531
60Steroid hormone biosynthesis_Homo sapiens_hsa001401.09095555
61Non-homologous end-joining_Homo sapiens_hsa034501.07667621
62Tryptophan metabolism_Homo sapiens_hsa003801.06941855
63Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.99892467
64Phosphatidylinositol signaling system_Homo sapiens_hsa040700.97839631
65Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.97570762
66Fatty acid metabolism_Homo sapiens_hsa012120.97473505
67cGMP-PKG signaling pathway_Homo sapiens_hsa040220.97280796
68Peroxisome_Homo sapiens_hsa041460.94022397
69Oocyte meiosis_Homo sapiens_hsa041140.91181063
70Ether lipid metabolism_Homo sapiens_hsa005650.90884735
71Homologous recombination_Homo sapiens_hsa034400.89866883
72Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.89389854
73Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.88623710
74ABC transporters_Homo sapiens_hsa020100.86828579
75Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.85087574
76Vibrio cholerae infection_Homo sapiens_hsa051100.84271207
77Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.83173998
78Dorso-ventral axis formation_Homo sapiens_hsa043200.82670839
79Vascular smooth muscle contraction_Homo sapiens_hsa042700.82036717
80Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.81996428
81Phospholipase D signaling pathway_Homo sapiens_hsa040720.81272683
82Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.79964313
83Dilated cardiomyopathy_Homo sapiens_hsa054140.78788537
84Cardiac muscle contraction_Homo sapiens_hsa042600.76416705
85Caffeine metabolism_Homo sapiens_hsa002320.76323717
86RNA degradation_Homo sapiens_hsa030180.76298516
87MAPK signaling pathway_Homo sapiens_hsa040100.75830992
88Retinol metabolism_Homo sapiens_hsa008300.75684549
89Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.75397999
90* Choline metabolism in cancer_Homo sapiens_hsa052310.74733806
91Chemical carcinogenesis_Homo sapiens_hsa052040.74405724
92Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.73922639
93Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.73906523
94beta-Alanine metabolism_Homo sapiens_hsa004100.70889767
95Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.69991343
96Wnt signaling pathway_Homo sapiens_hsa043100.69194416
97Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.68641140
98Neurotrophin signaling pathway_Homo sapiens_hsa047220.68368338
99Ras signaling pathway_Homo sapiens_hsa040140.68114300
100Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.67949714
101Fat digestion and absorption_Homo sapiens_hsa049750.67426196
102Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.67384584
103Endometrial cancer_Homo sapiens_hsa052130.66938705
104Type I diabetes mellitus_Homo sapiens_hsa049400.66736974
105TGF-beta signaling pathway_Homo sapiens_hsa043500.64679719
106Lysine degradation_Homo sapiens_hsa003100.63730672
107Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.62985797
108Rap1 signaling pathway_Homo sapiens_hsa040150.62550191
109Thyroid hormone synthesis_Homo sapiens_hsa049180.62539396
110Oxidative phosphorylation_Homo sapiens_hsa001900.61884485
111Regulation of autophagy_Homo sapiens_hsa041400.61625222
112Pancreatic secretion_Homo sapiens_hsa049720.61113589
113Phototransduction_Homo sapiens_hsa047440.60708898
114Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.60549336
115Glycerolipid metabolism_Homo sapiens_hsa005610.58673547
116Colorectal cancer_Homo sapiens_hsa052100.57729714
117Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.57001758
118Fatty acid degradation_Homo sapiens_hsa000710.56162911
119Alcoholism_Homo sapiens_hsa050340.55733233
120Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.55489859
121Glucagon signaling pathway_Homo sapiens_hsa049220.54654603
122VEGF signaling pathway_Homo sapiens_hsa043700.54465469
123Huntingtons disease_Homo sapiens_hsa050160.54211835
124Thyroid hormone signaling pathway_Homo sapiens_hsa049190.52605052
125Parkinsons disease_Homo sapiens_hsa050120.51943682
126Pentose and glucuronate interconversions_Homo sapiens_hsa000400.51820744
127Histidine metabolism_Homo sapiens_hsa003400.48684005
128mTOR signaling pathway_Homo sapiens_hsa041500.48355354
129Selenocompound metabolism_Homo sapiens_hsa004500.48181313
130Renal cell carcinoma_Homo sapiens_hsa052110.46140234
131Sphingolipid signaling pathway_Homo sapiens_hsa040710.46056567
132Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.45915023
133RNA polymerase_Homo sapiens_hsa030200.43145033
134Ovarian steroidogenesis_Homo sapiens_hsa049130.43108138
135Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.43002032
136Non-small cell lung cancer_Homo sapiens_hsa052230.42515794
137Circadian rhythm_Homo sapiens_hsa047100.40910139
138Cysteine and methionine metabolism_Homo sapiens_hsa002700.40771974
139Hedgehog signaling pathway_Homo sapiens_hsa043400.40570031
140Prion diseases_Homo sapiens_hsa050200.39612471
141Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.39598979
142Carbohydrate digestion and absorption_Homo sapiens_hsa049730.39580659
143Metabolic pathways_Homo sapiens_hsa011000.37053225
144Insulin signaling pathway_Homo sapiens_hsa049100.35640518
145Inositol phosphate metabolism_Homo sapiens_hsa005620.34417190
146Endocytosis_Homo sapiens_hsa041440.33603200
147Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.32512430
148Chemokine signaling pathway_Homo sapiens_hsa040620.31949859
149Longevity regulating pathway - mammal_Homo sapiens_hsa042110.30328896
150Hippo signaling pathway_Homo sapiens_hsa043900.29713649
151Regulation of actin cytoskeleton_Homo sapiens_hsa048100.29204251
152Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.28496438
153Bile secretion_Homo sapiens_hsa049760.26369232
154Basal cell carcinoma_Homo sapiens_hsa052170.26153465
155Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.25655097

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