SLC45A1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene was isolated initially from a region on chromosome 1p that is frequently deleted in human neuroblastoma, although no causal relationship has since been demonstrated. The encoded protein belongs to the glycoside-pentoside-hexuronide cation symporter transporter family and may play a role in glucose uptake. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1regulation of short-term neuronal synaptic plasticity (GO:0048172)5.81157767
2vocalization behavior (GO:0071625)5.54051918
3synaptic vesicle exocytosis (GO:0016079)5.49760109
4synaptic vesicle maturation (GO:0016188)5.48959571
5regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act5.31008384
6positive regulation of excitatory postsynaptic membrane potential (GO:2000463)5.27777963
7positive regulation of calcium ion-dependent exocytosis (GO:0045956)5.27337366
8regulation of synaptic vesicle exocytosis (GO:2000300)5.14791096
9neuron cell-cell adhesion (GO:0007158)5.11768567
10locomotory exploration behavior (GO:0035641)5.10106130
11glutamate secretion (GO:0014047)5.07728730
12protein localization to synapse (GO:0035418)4.86903805
13regulation of glutamate receptor signaling pathway (GO:1900449)4.84049448
14neuronal action potential propagation (GO:0019227)4.73646485
15synaptic vesicle docking involved in exocytosis (GO:0016081)4.59351873
16regulation of synaptic vesicle transport (GO:1902803)4.52313121
17neurotransmitter secretion (GO:0007269)4.51264035
18ionotropic glutamate receptor signaling pathway (GO:0035235)4.41644937
19exploration behavior (GO:0035640)4.23366141
20regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)4.22909551
21pyrimidine nucleobase catabolic process (GO:0006208)4.20197565
22regulation of neuronal synaptic plasticity (GO:0048168)4.08911349
23regulation of long-term neuronal synaptic plasticity (GO:0048169)4.08792703
24synaptic transmission, glutamatergic (GO:0035249)4.05345469
25glutamate receptor signaling pathway (GO:0007215)4.05314453
26neuron-neuron synaptic transmission (GO:0007270)4.00017935
27layer formation in cerebral cortex (GO:0021819)3.89318705
28regulation of synapse structural plasticity (GO:0051823)3.86005037
29gamma-aminobutyric acid transport (GO:0015812)3.84541435
30neurotransmitter-gated ion channel clustering (GO:0072578)3.79362397
31neuron recognition (GO:0008038)3.77540737
32neurotransmitter transport (GO:0006836)3.76889937
33proline transport (GO:0015824)3.71933550
34negative regulation of synaptic transmission, GABAergic (GO:0032229)3.71680956
35neuromuscular process controlling posture (GO:0050884)3.70298405
36transmission of nerve impulse (GO:0019226)3.67982774
37positive regulation of membrane potential (GO:0045838)3.67836125
38membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.65703112
39cerebellar Purkinje cell differentiation (GO:0021702)3.64752130
40dendritic spine morphogenesis (GO:0060997)3.64371947
41regulation of excitatory postsynaptic membrane potential (GO:0060079)3.62617708
42regulation of inhibitory postsynaptic membrane potential (GO:0060080)3.62484484
43long-term memory (GO:0007616)3.61978170
44gamma-aminobutyric acid signaling pathway (GO:0007214)3.54126016
45postsynaptic membrane organization (GO:0001941)3.53875579
46regulation of neurotransmitter secretion (GO:0046928)3.52932451
47regulation of postsynaptic membrane potential (GO:0060078)3.52343564
48synaptic vesicle endocytosis (GO:0048488)3.50250667
49nucleobase catabolic process (GO:0046113)3.50119588
50regulation of synapse maturation (GO:0090128)3.47627972
51regulation of neurotransmitter levels (GO:0001505)3.47425284
52axonal fasciculation (GO:0007413)3.46947858
53positive regulation of synaptic transmission, GABAergic (GO:0032230)3.46123361
54activation of protein kinase A activity (GO:0034199)3.45479946
55establishment of mitochondrion localization (GO:0051654)3.45056917
56cellular potassium ion homeostasis (GO:0030007)3.42584219
57regulation of synaptic transmission, glutamatergic (GO:0051966)3.41539999
58positive regulation of potassium ion transmembrane transporter activity (GO:1901018)3.39948862
59substrate-independent telencephalic tangential migration (GO:0021826)3.39012759
60substrate-independent telencephalic tangential interneuron migration (GO:0021843)3.39012759
61cerebellar Purkinje cell layer development (GO:0021680)3.38983493
62positive regulation of synapse maturation (GO:0090129)3.38359692
63presynaptic membrane assembly (GO:0097105)3.37305794
64regulation of synaptic plasticity (GO:0048167)3.36810812
65regulation of vesicle fusion (GO:0031338)3.35759446
66long-term synaptic potentiation (GO:0060291)3.35628962
67positive regulation of synaptic transmission, dopaminergic (GO:0032226)3.34077844
68negative regulation of synaptic transmission, glutamatergic (GO:0051967)3.31949058
69positive regulation of dendritic spine development (GO:0060999)3.30827212
70regulation of neurotransmitter transport (GO:0051588)3.30634107
71sodium ion export (GO:0071436)3.28515048
72cell migration in hindbrain (GO:0021535)3.23841960
73G-protein coupled glutamate receptor signaling pathway (GO:0007216)3.23209736
74neuromuscular synaptic transmission (GO:0007274)3.23129433
75positive regulation of dendritic spine morphogenesis (GO:0061003)3.22919137
76presynaptic membrane organization (GO:0097090)3.22139844
77positive regulation of neurotransmitter transport (GO:0051590)3.20759246
78regulation of dendritic spine morphogenesis (GO:0061001)3.20208678
79membrane depolarization during action potential (GO:0086010)3.19975957
80positive regulation of synaptic transmission, glutamatergic (GO:0051968)3.19209304
81response to auditory stimulus (GO:0010996)3.17946735
82membrane hyperpolarization (GO:0060081)3.17429065
83synapse assembly (GO:0007416)3.17040361
84regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)3.16032054
85membrane depolarization (GO:0051899)3.15860317
86auditory behavior (GO:0031223)3.14643888
87regulation of respiratory gaseous exchange by neurological system process (GO:0002087)3.13180427
88regulation of glutamate secretion (GO:0014048)3.12502204
89dendritic spine organization (GO:0097061)3.12466221
90adult walking behavior (GO:0007628)3.11822648
91C4-dicarboxylate transport (GO:0015740)3.09959249
92neuromuscular process controlling balance (GO:0050885)3.08057649
93learning (GO:0007612)3.06457141
94synaptic transmission (GO:0007268)3.06449971
95neurofilament cytoskeleton organization (GO:0060052)3.05790956
96response to pheromone (GO:0019236)3.04878843
97behavioral response to cocaine (GO:0048148)3.02754585
98neuronal ion channel clustering (GO:0045161)3.02587880
99positive regulation of neurotransmitter secretion (GO:0001956)3.02357884
100cell communication by electrical coupling (GO:0010644)3.02161408
101prepulse inhibition (GO:0060134)3.01843854
102regulation of synaptic transmission (GO:0050804)3.00759335
103response to histamine (GO:0034776)3.00400857
104vesicle transport along microtubule (GO:0047496)3.00167508
105synaptic vesicle transport (GO:0048489)3.00131194
106establishment of synaptic vesicle localization (GO:0097480)3.00131194
107mating behavior (GO:0007617)2.98922359
108dendrite morphogenesis (GO:0048813)2.98845310
109positive regulation of synaptic transmission (GO:0050806)2.98655440
110cerebellar granule cell differentiation (GO:0021707)2.97572629
111negative regulation of microtubule polymerization (GO:0031115)2.97303729
112positive regulation of synapse assembly (GO:0051965)2.95833685
113glycine transport (GO:0015816)2.95730371
114cell communication by electrical coupling involved in cardiac conduction (GO:0086064)2.95225680
115regulation of synaptic transmission, GABAergic (GO:0032228)2.93998297
116startle response (GO:0001964)2.92945024
117intraspecies interaction between organisms (GO:0051703)2.91831934
118mitochondrion transport along microtubule (GO:0047497)2.91188437
119establishment of mitochondrion localization, microtubule-mediated (GO:0034643)2.91188437
120mechanosensory behavior (GO:0007638)2.89658455
121cell differentiation in hindbrain (GO:0021533)2.85320637
122serotonin metabolic process (GO:0042428)2.75946144
123innervation (GO:0060384)2.75421776
124regulation of dendritic spine development (GO:0060998)2.75074672
125regulation of respiratory system process (GO:0044065)2.74977403
126axon extension (GO:0048675)2.74338293

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human6.38858569
2GBX2_23144817_ChIP-Seq_PC3_Human3.81183346
3SUZ12_18692474_ChIP-Seq_MESCs_Mouse3.25290905
4JARID2_20064375_ChIP-Seq_MESCs_Mouse3.21347167
5SUZ12_18555785_ChIP-Seq_MESCs_Mouse3.12658466
6REST_21632747_ChIP-Seq_MESCs_Mouse2.85813568
7EZH2_18974828_ChIP-Seq_MESCs_Mouse2.80248755
8RNF2_18974828_ChIP-Seq_MESCs_Mouse2.80248755
9JARID2_20075857_ChIP-Seq_MESCs_Mouse2.76011816
10SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.70449067
11EZH2_27304074_Chip-Seq_ESCs_Mouse2.64897570
12SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.61366773
13SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.56831366
14SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.55104204
15MTF2_20144788_ChIP-Seq_MESCs_Mouse2.53419897
16EED_16625203_ChIP-ChIP_MESCs_Mouse2.40748349
17DROSHA_22980978_ChIP-Seq_HELA_Human2.37950766
18RARB_27405468_Chip-Seq_BRAIN_Mouse2.35471583
19SUZ12_27294783_Chip-Seq_ESCs_Mouse2.33675977
20EZH2_27294783_Chip-Seq_ESCs_Mouse2.31852524
21REST_18959480_ChIP-ChIP_MESCs_Mouse2.30301046
22NR4A2_19515692_ChIP-ChIP_MN9D_Mouse2.25630314
23TAF15_26573619_Chip-Seq_HEK293_Human2.20742566
24RNF2_27304074_Chip-Seq_ESCs_Mouse2.18640880
25CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons2.17945989
26IKZF1_21737484_ChIP-ChIP_HCT116_Human2.13784285
27CTBP2_25329375_ChIP-Seq_LNCAP_Human1.91468225
28GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.83267090
29* AR_21572438_ChIP-Seq_LNCaP_Human1.82597068
30SRY_22984422_ChIP-ChIP_TESTIS_Rat1.77625158
31CTBP1_25329375_ChIP-Seq_LNCAP_Human1.77154788
32ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.73545870
33MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.70147851
34SMAD4_21799915_ChIP-Seq_A2780_Human1.68058799
35ZFP57_27257070_Chip-Seq_ESCs_Mouse1.65822895
36EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.64794244
37TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.64347010
38BMI1_23680149_ChIP-Seq_NPCS_Mouse1.57075615
39ERG_21242973_ChIP-ChIP_JURKAT_Human1.56039063
40SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.52571640
41* PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.51130314
42PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.48958485
43* P300_19829295_ChIP-Seq_ESCs_Human1.48523378
44IGF1R_20145208_ChIP-Seq_DFB_Human1.46484259
45TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.43957368
46CBX2_27304074_Chip-Seq_ESCs_Mouse1.43917004
47ZNF274_21170338_ChIP-Seq_K562_Hela1.39107126
48GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.36793296
49SMAD3_21741376_ChIP-Seq_EPCs_Human1.35086567
50SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.34858946
51RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.33041700
52RNF2_27304074_Chip-Seq_NSC_Mouse1.31421630
53TOP2B_26459242_ChIP-Seq_MCF-7_Human1.31266030
54* CTCF_27219007_Chip-Seq_Bcells_Human1.31153896
55THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.30949781
56RING1B_27294783_Chip-Seq_ESCs_Mouse1.29870105
57NR3C1_23031785_ChIP-Seq_PC12_Mouse1.28736030
58SOX2_21211035_ChIP-Seq_LN229_Gbm1.28551038
59* AR_25329375_ChIP-Seq_VCAP_Human1.27949359
60RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.27694064
61* SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.22467971
62* TP53_20018659_ChIP-ChIP_R1E_Mouse1.21668397
63STAT3_23295773_ChIP-Seq_U87_Human1.20001422
64* OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.19122749
65OLIG2_26023283_ChIP-Seq_AINV15_Mouse1.17273060
66TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.14105378
67* PIAS1_25552417_ChIP-Seq_VCAP_Human1.13460609
68POU3F2_20337985_ChIP-ChIP_501MEL_Human1.12176749
69AR_19668381_ChIP-Seq_PC3_Human1.12046199
70P53_22127205_ChIP-Seq_FIBROBLAST_Human1.11983959
71ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.10284580
72TCF4_23295773_ChIP-Seq_U87_Human1.08124420
73DNAJC2_21179169_ChIP-ChIP_NT2_Human1.08062553
74SMAD_19615063_ChIP-ChIP_OVARY_Human1.06913597
75CDX2_19796622_ChIP-Seq_MESCs_Mouse1.04402349
76RING1B_27294783_Chip-Seq_NPCs_Mouse1.04401364
77ER_23166858_ChIP-Seq_MCF-7_Human1.04260518
78TRIM28_21343339_ChIP-Seq_HEK293_Human1.03480352
79UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.03068100
80CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.02931951
81RUNX2_22187159_ChIP-Seq_PCA_Human1.02761154
82JUN_21703547_ChIP-Seq_K562_Human1.01495365
83ARNT_22903824_ChIP-Seq_MCF-7_Human1.00549823
84* PRDM14_20953172_ChIP-Seq_ESCs_Human0.99927930
85WT1_25993318_ChIP-Seq_PODOCYTE_Human0.99239952
86FUS_26573619_Chip-Seq_HEK293_Human0.98985759
87* MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.97714584
88YAP1_20516196_ChIP-Seq_MESCs_Mouse0.97489782
89SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.97415839
90AHR_22903824_ChIP-Seq_MCF-7_Human0.97261753
91AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.96342126
92SMAD3_21741376_ChIP-Seq_ESCs_Human0.95331087
93SIN3B_21632747_ChIP-Seq_MESCs_Mouse0.94677604
94POU5F1_26923725_Chip-Seq_MESODERM_Mouse0.93669417
95TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.93669417
96TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.93384971
97TET1_21490601_ChIP-Seq_MESCs_Mouse0.93166682
98NR3C1_21868756_ChIP-Seq_MCF10A_Human0.92327687
99KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse0.91178268
100* KDM2B_26808549_Chip-Seq_K562_Human0.90344110
101EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse0.89646662
102CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human0.89358505
103VDR_22108803_ChIP-Seq_LS180_Human0.88740169
104SMAD4_21741376_ChIP-Seq_HESCs_Human0.88658693
105RCOR2_21632747_ChIP-Seq_MESCs_Mouse0.86842220
106* ZNF217_24962896_ChIP-Seq_MCF-7_Human0.86601945
107NANOG_18555785_Chip-Seq_ESCs_Mouse0.85464715
108* TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse0.84472832
109EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human0.83149820
110KDM2B_26808549_Chip-Seq_REH_Human0.82094949
111VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human0.81816397
112TFAP2C_20629094_ChIP-Seq_MCF-7_Human0.81721679
113ZFP281_18757296_ChIP-ChIP_E14_Mouse0.80233654
114SMAD3_22036565_ChIP-Seq_ESCs_Mouse0.79928183
115LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.79487752
116WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse0.79241115
117PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse0.79074019
118* PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.78563045
119* FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse0.78557501
120* ELK4_26923725_Chip-Seq_MESODERM_Mouse0.75814808
121SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.74656825
122OCT4_19829295_ChIP-Seq_ESCs_Human0.73392847
123ZFP281_27345836_Chip-Seq_ESCs_Mouse0.70395615
124TP53_18474530_ChIP-ChIP_U2OS_Human0.70005358

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity5.72732454
2MP0003880_abnormal_central_pattern5.05736188
3MP0003635_abnormal_synaptic_transmissio3.99983479
4MP0004270_analgesia3.54202064
5MP0009745_abnormal_behavioral_response3.36763149
6MP0001968_abnormal_touch/_nociception3.28846518
7MP0009046_muscle_twitch3.28099422
8MP0002064_seizures3.17755757
9MP0002063_abnormal_learning/memory/cond3.15260363
10MP0005423_abnormal_somatic_nervous3.14139773
11MP0002572_abnormal_emotion/affect_behav2.80266923
12MP0002734_abnormal_mechanical_nocicepti2.78597185
13MP0002272_abnormal_nervous_system2.72784637
14MP0002822_catalepsy2.69827803
15MP0002735_abnormal_chemical_nociception2.66689130
16MP0002736_abnormal_nociception_after2.61412145
17MP0001486_abnormal_startle_reflex2.57441560
18MP0006276_abnormal_autonomic_nervous2.43174787
19MP0001501_abnormal_sleep_pattern2.32849395
20MP0001440_abnormal_grooming_behavior2.31448903
21MP0002733_abnormal_thermal_nociception2.29583477
22MP0001970_abnormal_pain_threshold2.18522838
23MP0002067_abnormal_sensory_capabilities2.13903347
24MP0002184_abnormal_innervation2.05548289
25MP0001984_abnormal_olfaction2.00468353
26MP0003283_abnormal_digestive_organ2.00406629
27MP0000778_abnormal_nervous_system1.89079636
28MP0001529_abnormal_vocalization1.88492468
29MP0004924_abnormal_behavior1.86876282
30MP0005386_behavior/neurological_phenoty1.86876282
31MP0004858_abnormal_nervous_system1.86306145
32MP0005645_abnormal_hypothalamus_physiol1.85857831
33MP0002557_abnormal_social/conspecific_i1.82800179
34MP0008569_lethality_at_weaning1.81713176
35MP0004811_abnormal_neuron_physiology1.72528124
36MP0003329_amyloid_beta_deposits1.68145683
37MP0005646_abnormal_pituitary_gland1.67754953
38MP0004142_abnormal_muscle_tone1.62726030
39MP0003122_maternal_imprinting1.62074105
40MP0000955_abnormal_spinal_cord1.58613058
41MP0001905_abnormal_dopamine_level1.53859793
42MP0003879_abnormal_hair_cell1.53813161
43MP0003123_paternal_imprinting1.51425014
44MP0003787_abnormal_imprinting1.48870406
45MP0002909_abnormal_adrenal_gland1.46476982
46MP0002882_abnormal_neuron_morphology1.45440986
47MP0002066_abnormal_motor_capabilities/c1.44448655
48MP0001188_hyperpigmentation1.28936454
49MP0009780_abnormal_chondrocyte_physiolo1.26040510
50MP0001502_abnormal_circadian_rhythm1.24798488
51MP0003633_abnormal_nervous_system1.21155199
52MP0004885_abnormal_endolymph1.19311289
53MP0004742_abnormal_vestibular_system1.18493072
54MP0002653_abnormal_ependyma_morphology1.10329364
55MP0010386_abnormal_urinary_bladder1.09613808
56MP0002152_abnormal_brain_morphology1.08304658
57MP0003631_nervous_system_phenotype1.07907473
58MP0009379_abnormal_foot_pigmentation1.07489656
59MP0002234_abnormal_pharynx_morphology1.07435119
60MP0008872_abnormal_physiological_respon1.06959687
61MP0004133_heterotaxia1.05577363
62MP0000751_myopathy1.04881082
63MP0002229_neurodegeneration1.03695180
64MP0000750_abnormal_muscle_regeneration1.01547520
65MP0000049_abnormal_middle_ear0.96488170
66MP0005187_abnormal_penis_morphology0.94631091
67MP0003011_delayed_dark_adaptation0.94328533
68MP0002069_abnormal_eating/drinking_beha0.92575784
69MP0005394_taste/olfaction_phenotype0.90961294
70MP0005499_abnormal_olfactory_system0.90961294
71MP0005551_abnormal_eye_electrophysiolog0.90615396
72MP0001963_abnormal_hearing_physiology0.89839786
73MP0004145_abnormal_muscle_electrophysio0.89682132
74MP0003938_abnormal_ear_development0.88266482
75MP0002752_abnormal_somatic_nervous0.87709414
76MP0001986_abnormal_taste_sensitivity0.86974541
77MP0003634_abnormal_glial_cell0.86813604
78MP0008874_decreased_physiological_sensi0.86642938
79MP0000920_abnormal_myelination0.86107037
80MP0002102_abnormal_ear_morphology0.85857292
81MP0005623_abnormal_meninges_morphology0.83376096
82MP0000631_abnormal_neuroendocrine_gland0.81426186
83MP0005535_abnormal_body_temperature0.79666292
84MP0003632_abnormal_nervous_system0.79195421
85MP0001177_atelectasis0.77640027
86MP0004085_abnormal_heartbeat0.76283155
87MP0003119_abnormal_digestive_system0.75909092
88MP0005409_darkened_coat_color0.74770834
89MP0005253_abnormal_eye_physiology0.74661498
90MP0001485_abnormal_pinna_reflex0.73792636
91MP0002876_abnormal_thyroid_physiology0.71844189
92MP0001664_abnormal_digestion0.71704380
93MP0002837_dystrophic_cardiac_calcinosis0.71303580
94MP0000604_amyloidosis0.71099498
95MP0008877_abnormal_DNA_methylation0.70561126
96MP0003690_abnormal_glial_cell0.68538353
97MP0000013_abnormal_adipose_tissue0.65179959
98MP0002638_abnormal_pupillary_reflex0.64958262
99MP0000534_abnormal_ureter_morphology0.64936699
100MP0003942_abnormal_urinary_system0.62263502
101MP0002090_abnormal_vision0.60257780
102MP0000566_synostosis0.59939998
103MP0001943_abnormal_respiration0.59376406
104MP0003137_abnormal_impulse_conducting0.59226068
105MP0000537_abnormal_urethra_morphology0.59221243
106MP0002751_abnormal_autonomic_nervous0.58667179
107MP0003075_altered_response_to0.56361960
108MP0008961_abnormal_basal_metabolism0.54672657
109MP0000026_abnormal_inner_ear0.53707079
110MP0004215_abnormal_myocardial_fiber0.53317526
111MP0010769_abnormal_survival0.52778307
112MP0001299_abnormal_eye_distance/0.52712110
113MP0003861_abnormal_nervous_system0.52437976
114MP0010770_preweaning_lethality0.51879783
115MP0002082_postnatal_lethality0.51879783
116MP0004484_altered_response_of0.51833110
117MP0003121_genomic_imprinting0.50374044
118MP0001348_abnormal_lacrimal_gland0.50364913
119MP0006072_abnormal_retinal_apoptosis0.49939501
120MP0010768_mortality/aging0.49726056

Predicted human phenotypes

RankGene SetZ-score
1Focal motor seizures (HP:0011153)7.63885616
2Myokymia (HP:0002411)7.04908513
3Focal seizures (HP:0007359)5.76274340
4Atonic seizures (HP:0010819)5.21104884
5Visual hallucinations (HP:0002367)5.13476003
6Febrile seizures (HP:0002373)4.94359948
7Epileptic encephalopathy (HP:0200134)4.80968077
8Progressive cerebellar ataxia (HP:0002073)4.48712553
9Absence seizures (HP:0002121)4.42581647
10Dialeptic seizures (HP:0011146)4.00460085
11Generalized tonic-clonic seizures (HP:0002069)3.91093953
12Supranuclear gaze palsy (HP:0000605)3.78001456
13Action tremor (HP:0002345)3.70928018
14Broad-based gait (HP:0002136)3.37626586
15Ankle clonus (HP:0011448)3.36621385
16Hyperventilation (HP:0002883)3.23036714
17Abnormal eating behavior (HP:0100738)3.17036791
18Gaze-evoked nystagmus (HP:0000640)3.16431870
19Impaired vibration sensation in the lower limbs (HP:0002166)3.15959219
20Limb dystonia (HP:0002451)3.13437168
21Poor eye contact (HP:0000817)3.10144209
22Progressive inability to walk (HP:0002505)3.06775709
23Truncal ataxia (HP:0002078)3.06751350
24Amblyopia (HP:0000646)3.00299015
25Anxiety (HP:0000739)2.98733311
26Mutism (HP:0002300)2.96494666
27Pheochromocytoma (HP:0002666)2.96338106
28Depression (HP:0000716)2.95222159
29Dysmetria (HP:0001310)2.94923970
30Urinary bladder sphincter dysfunction (HP:0002839)2.89068212
31Dysdiadochokinesis (HP:0002075)2.88370094
32Lissencephaly (HP:0001339)2.86229237
33Abnormal social behavior (HP:0012433)2.83928790
34Impaired social interactions (HP:0000735)2.83928790
35Polyphagia (HP:0002591)2.77501909
36Neuroendocrine neoplasm (HP:0100634)2.70455801
37Urinary urgency (HP:0000012)2.65593852
38Scanning speech (HP:0002168)2.64593465
39Spastic gait (HP:0002064)2.61279518
40Postural instability (HP:0002172)2.60707146
41Annular pancreas (HP:0001734)2.60521340
42Abnormality of the corticospinal tract (HP:0002492)2.60248050
43Abnormality of binocular vision (HP:0011514)2.53191916
44Diplopia (HP:0000651)2.53191916
45Termporal pattern (HP:0011008)2.51637689
46Insidious onset (HP:0003587)2.51637689
47Hemiparesis (HP:0001269)2.48224359
48Fetal akinesia sequence (HP:0001989)2.46390346
49Genetic anticipation (HP:0003743)2.45681581
50Aplasia involving bones of the upper limbs (HP:0009823)2.45577363
51Aplasia of the phalanges of the hand (HP:0009802)2.45577363
52Aplasia involving bones of the extremities (HP:0009825)2.45577363
53Inability to walk (HP:0002540)2.45540468
54Excessive salivation (HP:0003781)2.43477135
55Drooling (HP:0002307)2.43477135
56Failure to thrive in infancy (HP:0001531)2.42407540
57Torticollis (HP:0000473)2.41245779
58Epileptiform EEG discharges (HP:0011182)2.38874591
59Neurofibrillary tangles (HP:0002185)2.35268768
60Cerebral inclusion bodies (HP:0100314)2.34274084
61Bradykinesia (HP:0002067)2.33330089
62Type II lissencephaly (HP:0007260)2.30273917
63EEG with generalized epileptiform discharges (HP:0011198)2.29907991
64Impaired smooth pursuit (HP:0007772)2.27955368
65Papilledema (HP:0001085)2.23678176
66Spastic tetraplegia (HP:0002510)2.23675875
67Absent speech (HP:0001344)2.23314084
68Focal dystonia (HP:0004373)2.23051660
69Abnormal hair whorl (HP:0010721)2.22630333
70Lower limb muscle weakness (HP:0007340)2.21081951
71Status epilepticus (HP:0002133)2.18263422
72Hypsarrhythmia (HP:0002521)2.15858804
73Split foot (HP:0001839)2.13299201
74Hemiplegia (HP:0002301)2.11761010
75Intention tremor (HP:0002080)2.11420288
76Agitation (HP:0000713)2.10792986
77Stereotypic behavior (HP:0000733)2.08474467
78Ventricular fibrillation (HP:0001663)2.07795424
79Gait imbalance (HP:0002141)2.05943989
80Neoplasm of the heart (HP:0100544)2.04824970
81Megalencephaly (HP:0001355)2.03092832
82Craniofacial dystonia (HP:0012179)2.02721159
83Generalized myoclonic seizures (HP:0002123)2.01477725
84Specific learning disability (HP:0001328)1.99427811
85Hypoventilation (HP:0002791)1.98824221
86Psychosis (HP:0000709)1.98550165
87Abnormality of ocular smooth pursuit (HP:0000617)1.97811786
88Esotropia (HP:0000565)1.97677435
89Impaired vibratory sensation (HP:0002495)1.97464538
90Decreased number of large peripheral myelinated nerve fibers (HP:0003387)1.97432865
91Morphological abnormality of the pyramidal tract (HP:0002062)1.95896181
92Poor suck (HP:0002033)1.94770936
93Morphological abnormality of the middle ear (HP:0008609)1.93817594
94Incomplete penetrance (HP:0003829)1.92341183
95Abnormality of the lower motor neuron (HP:0002366)1.91719819
96Delusions (HP:0000746)1.91718167
97Degeneration of the lateral corticospinal tracts (HP:0002314)1.90376891
98Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)1.90376891
99Neoplasm of the peripheral nervous system (HP:0100007)1.89633785
100Ulnar claw (HP:0001178)1.88048683
101Akinesia (HP:0002304)1.87127027
102Sleep apnea (HP:0010535)1.86845461
103Neuronal loss in central nervous system (HP:0002529)1.86208534
104Blue irides (HP:0000635)1.83755818
105Clonus (HP:0002169)1.82635175
106Gait ataxia (HP:0002066)1.81452271
107Nephrogenic diabetes insipidus (HP:0009806)1.81370376
108Myotonia (HP:0002486)1.81354082
109Cerebral hypomyelination (HP:0006808)1.81323378
110Retinal dysplasia (HP:0007973)1.81260021
111Hyperthyroidism (HP:0000836)1.80551895
112Aplasia/Hypoplasia of the brainstem (HP:0007362)1.79576728
113Hypoplasia of the brainstem (HP:0002365)1.79576728
114Thyroid-stimulating hormone excess (HP:0002925)1.78702940
115Muscular hypotonia of the trunk (HP:0008936)1.78638927
116Abnormality of saccadic eye movements (HP:0000570)1.76687603
117Lower limb amyotrophy (HP:0007210)1.73127069
118Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)1.72239950
119Narrow nasal bridge (HP:0000446)1.72016326
120Rigidity (HP:0002063)1.71697073
121Hypoplastic nipples (HP:0002557)1.70946431
122Spinal canal stenosis (HP:0003416)1.68296626
123Open mouth (HP:0000194)1.66654609
124Insomnia (HP:0100785)1.64717531
125Turricephaly (HP:0000262)1.64517288
126Generalized hypotonia (HP:0001290)1.64192405

Predicted kinase interactions (KEA)

RankGene SetZ-score
1NTRK34.46859598
2MAP3K93.70886104
3EPHA43.46416606
4MARK13.23312670
5MAP3K43.21022174
6MAP3K122.95745310
7MAP2K72.84443443
8MINK12.77899410
9CASK2.76081328
10MAP2K42.17163524
11DAPK22.04176478
12NTRK22.03164248
13PAK62.02186295
14NTRK11.97446275
15ARAF1.82312730
16RIPK41.72857587
17KSR21.72769442
18GRK51.70755813
19CDK191.67429043
20SIK21.65778285
21PNCK1.62885655
22TNIK1.61483406
23PLK21.60292706
24MAPK131.59086294
25CDK51.49703435
26CAMKK11.45861691
27PRPF4B1.44798161
28MAP4K21.44635915
29KSR11.43797180
30SIK31.38186248
31DAPK11.38015417
32EPHB21.33728346
33PRKD31.26382786
34UHMK11.24633041
35PHKG21.23473841
36PHKG11.23473841
37WNK31.22209289
38PRKCG1.22097378
39CAMKK21.18287461
40STK381.10356056
41TESK11.07702444
42DYRK21.07638095
43FES1.05209793
44OXSR11.03457854
45CAMK2A1.02152219
46MAP3K130.99242698
47LATS20.96023115
48SGK2230.91208889
49SGK4940.91208889
50CDK180.91110568
51CAMK2B0.90267420
52CDK150.86776269
53CDK140.86179467
54CSNK1G20.85644369
55NME10.85616760
56DYRK1B0.79422248
57MAP3K20.78701156
58CAMK10.78075615
59CDK11A0.76289965
60STK110.74478381
61PAK30.74297278
62CAMK40.74006744
63BMPR20.73257009
64RAF10.72862269
65TYRO30.71779296
66TESK20.71059401
67MARK20.70537270
68GRK70.68320961
69SGK20.67612911
70RET0.67546960
71LMTK20.66929187
72DYRK1A0.66670170
73SIK10.66092713
74PTK2B0.65597830
75BCR0.64925571
76WNK10.64734717
77PRKCH0.62858858
78BCKDK0.62268560
79CAMK2G0.62135912
80PRKCE0.60714415
81CSNK1A1L0.58891652
82PRKD20.58779067
83DMPK0.57717913
84TAOK10.57476872
85MAPK120.56694379
86SGK10.56245271
87TNK20.55724092
88FGR0.55444652
89CAMK2D0.54980568
90CCNB10.54678621
91CSNK1G10.53553759
92BRAF0.53301657
93ERBB20.52917234
94CAMK1G0.52052757
95DAPK30.50606975
96PINK10.50358084
97LIMK10.49740081
98PRKACA0.49655320
99ADRBK20.48310267
100SMG10.48254705
101PRKAA10.47943246
102PTK20.46829049
103MAP3K10.46692668
104SGK30.46537767
105CSNK1A10.45680229
106PRKCZ0.45546536
107MAP3K110.45047827
108STK390.44740634
109ADRBK10.44324400
110MUSK0.44311647
111PDK10.44071926
112NEK60.43067512
113MAP2K60.42696942
114PRKCA0.41610312
115ROCK20.41290166
116PDPK10.40929144
117RPS6KA20.40911304
118PRKG10.40237294
119CSNK1G30.39745362
120RPS6KA30.39712777
121FYN0.39034125
122MAPKAPK50.38781543
123MAPK100.38087545
124MAPK150.36350898
125FER0.35968626
126PKN10.35402939
127ALK0.34552657
128MAP3K60.33175388

Predicted pathways (KEGG)

RankGene SetZ-score
1Nicotine addiction_Homo sapiens_hsa050333.93878467
2Synaptic vesicle cycle_Homo sapiens_hsa047213.76054416
3Olfactory transduction_Homo sapiens_hsa047402.93847189
4GABAergic synapse_Homo sapiens_hsa047272.79599646
5Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.78407571
6Circadian entrainment_Homo sapiens_hsa047132.61461194
7Morphine addiction_Homo sapiens_hsa050322.56783448
8Glutamatergic synapse_Homo sapiens_hsa047242.52947251
9Long-term potentiation_Homo sapiens_hsa047202.46925164
10Amphetamine addiction_Homo sapiens_hsa050312.37889066
11Dopaminergic synapse_Homo sapiens_hsa047282.23631646
12Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049612.16466262
13Salivary secretion_Homo sapiens_hsa049702.06935561
14Collecting duct acid secretion_Homo sapiens_hsa049662.03535608
15Taste transduction_Homo sapiens_hsa047422.00505748
16Insulin secretion_Homo sapiens_hsa049111.97985630
17Cholinergic synapse_Homo sapiens_hsa047251.90524196
18Serotonergic synapse_Homo sapiens_hsa047261.82084603
19Gastric acid secretion_Homo sapiens_hsa049711.78124840
20Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.76209291
21Cocaine addiction_Homo sapiens_hsa050301.73540244
22Long-term depression_Homo sapiens_hsa047301.69813102
23Aldosterone synthesis and secretion_Homo sapiens_hsa049251.67911775
24Renin secretion_Homo sapiens_hsa049241.60015993
25Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.56856266
26Sulfur metabolism_Homo sapiens_hsa009201.56732429
27Calcium signaling pathway_Homo sapiens_hsa040201.55055292
28Oxytocin signaling pathway_Homo sapiens_hsa049211.53379893
29GnRH signaling pathway_Homo sapiens_hsa049121.38898224
30Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.37952335
31Gap junction_Homo sapiens_hsa045401.33256775
32Vibrio cholerae infection_Homo sapiens_hsa051101.32801652
33Cardiac muscle contraction_Homo sapiens_hsa042601.25231163
34Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.24439734
35Axon guidance_Homo sapiens_hsa043601.18327725
36Oxidative phosphorylation_Homo sapiens_hsa001901.17721503
37cAMP signaling pathway_Homo sapiens_hsa040241.16922225
38Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.08027270
39Estrogen signaling pathway_Homo sapiens_hsa049151.07520770
40Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.04696976
41Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051201.03406476
42Phosphatidylinositol signaling system_Homo sapiens_hsa040701.01998234
43Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.01355893
44ErbB signaling pathway_Homo sapiens_hsa040121.00271398
45Type II diabetes mellitus_Homo sapiens_hsa049300.99230289
46Alzheimers disease_Homo sapiens_hsa050100.99167047
47Parkinsons disease_Homo sapiens_hsa050120.97337381
48Glioma_Homo sapiens_hsa052140.94367089
49Melanogenesis_Homo sapiens_hsa049160.93724628
50Phototransduction_Homo sapiens_hsa047440.93156516
51Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.89819319
52cGMP-PKG signaling pathway_Homo sapiens_hsa040220.88794711
53Vascular smooth muscle contraction_Homo sapiens_hsa042700.86005695
54Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.79281209
55Sulfur relay system_Homo sapiens_hsa041220.78899041
56Oocyte meiosis_Homo sapiens_hsa041140.77533117
57Pancreatic secretion_Homo sapiens_hsa049720.74214661
58MAPK signaling pathway_Homo sapiens_hsa040100.72733957
59Phospholipase D signaling pathway_Homo sapiens_hsa040720.71530265
60Dorso-ventral axis formation_Homo sapiens_hsa043200.69609701
61Hedgehog signaling pathway_Homo sapiens_hsa043400.68805353
62Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.68424992
63Thyroid hormone synthesis_Homo sapiens_hsa049180.68237676
64Type I diabetes mellitus_Homo sapiens_hsa049400.67683033
65Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.63769508
66Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.63524085
67Fatty acid biosynthesis_Homo sapiens_hsa000610.62544778
68Huntingtons disease_Homo sapiens_hsa050160.62078748
69Dilated cardiomyopathy_Homo sapiens_hsa054140.60791801
70Ras signaling pathway_Homo sapiens_hsa040140.58616250
71Neurotrophin signaling pathway_Homo sapiens_hsa047220.58004654
72Alcoholism_Homo sapiens_hsa050340.56079894
73Choline metabolism in cancer_Homo sapiens_hsa052310.56070062
74Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.55264745
75Hippo signaling pathway_Homo sapiens_hsa043900.55104305
76Butanoate metabolism_Homo sapiens_hsa006500.55048887
77SNARE interactions in vesicular transport_Homo sapiens_hsa041300.53798146
78Basal cell carcinoma_Homo sapiens_hsa052170.53084013
79Vitamin B6 metabolism_Homo sapiens_hsa007500.51542878
80Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.49902479
81Sphingolipid signaling pathway_Homo sapiens_hsa040710.49267561
82Rheumatoid arthritis_Homo sapiens_hsa053230.49160013
83Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.46153310
84VEGF signaling pathway_Homo sapiens_hsa043700.45704251
85Glucagon signaling pathway_Homo sapiens_hsa049220.45648580
86Rap1 signaling pathway_Homo sapiens_hsa040150.43494108
87Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.43276988
88Carbohydrate digestion and absorption_Homo sapiens_hsa049730.41432105
89Inositol phosphate metabolism_Homo sapiens_hsa005620.41268293
90Prion diseases_Homo sapiens_hsa050200.40551699
91AMPK signaling pathway_Homo sapiens_hsa041520.39870161
92Endocytosis_Homo sapiens_hsa041440.39206913
93Arginine and proline metabolism_Homo sapiens_hsa003300.38307722
94Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.37101672
95Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.36994840
96Ovarian steroidogenesis_Homo sapiens_hsa049130.35784660
97African trypanosomiasis_Homo sapiens_hsa051430.35441945
98Wnt signaling pathway_Homo sapiens_hsa043100.34743586
99Renal cell carcinoma_Homo sapiens_hsa052110.33844257
100Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.33019746
101Thyroid hormone signaling pathway_Homo sapiens_hsa049190.32606287
102Tight junction_Homo sapiens_hsa045300.32583390
103Bile secretion_Homo sapiens_hsa049760.32051384
104Phagosome_Homo sapiens_hsa041450.31961236
105Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.31227296
106Insulin signaling pathway_Homo sapiens_hsa049100.31011566
107Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.30612950
108Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.30494864
109Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.30237511
110Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.29292214
111Ether lipid metabolism_Homo sapiens_hsa005650.29275716
112Circadian rhythm_Homo sapiens_hsa047100.29169207
113Chemokine signaling pathway_Homo sapiens_hsa040620.27976102
114Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.26850555
115Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.26135096
116Endometrial cancer_Homo sapiens_hsa052130.25370796
117Non-small cell lung cancer_Homo sapiens_hsa052230.23333866
118Phenylalanine metabolism_Homo sapiens_hsa003600.22340346
119Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.20803776

Most similar genes based on co-expression Upload to Enrichr

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