SLC45A3

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1branching involved in prostate gland morphogenesis (GO:0060442)8.86202293
2iron ion import (GO:0097286)8.14854847
3biotin metabolic process (GO:0006768)7.09689781
4protein autoprocessing (GO:0016540)6.98126375
5piRNA metabolic process (GO:0034587)6.86093369
6endothelial cell chemotaxis (GO:0035767)6.56519006
7female gamete generation (GO:0007292)6.46918664
8artery development (GO:0060840)6.28845004
9import into cell (GO:0098657)6.07950106
10regulation of meiosis (GO:0040020)5.98161024
11prostate epithelial cord arborization involved in prostate glandular acinus morphogenesis (GO:0060525.58983676
12regulation of receptor binding (GO:1900120)5.56148002
13linoleic acid metabolic process (GO:0043651)5.52595273
14negative regulation of meiotic cell cycle (GO:0051447)5.51325279
15regulation of epithelial cell proliferation involved in prostate gland development (GO:0060768)5.47766513
16adenosine metabolic process (GO:0046085)5.47193338
17prostate gland epithelium morphogenesis (GO:0060740)5.46878877
18positive regulation of steroid hormone secretion (GO:2000833)5.25751760
19adaptation of signaling pathway (GO:0023058)5.25082377
20mitotic chromosome condensation (GO:0007076)5.22106047
21regulation of DNA methylation (GO:0044030)5.14551004
22long-chain fatty-acyl-CoA biosynthetic process (GO:0035338)5.11633860
23regulation of acrosome reaction (GO:0060046)5.09269938
24detection of temperature stimulus (GO:0016048)5.04586763
25carnitine shuttle (GO:0006853)5.02669711
26peptidyl-tyrosine autophosphorylation (GO:0038083)5.00473395
27meiotic cell cycle (GO:0051321)4.98452073
28positive regulation of G-protein coupled receptor protein signaling pathway (GO:0045745)4.94302699
29mitotic metaphase plate congression (GO:0007080)4.85109099
30epithelial cell maturation (GO:0002070)4.83689529
31protein K6-linked ubiquitination (GO:0085020)4.74391870
32positive regulation of chemokine secretion (GO:0090197)4.74181072
33regulation of meiotic cell cycle (GO:0051445)4.73214916
34positive regulation of macrophage cytokine production (GO:0060907)4.72136721
35negative regulation of meiosis (GO:0045835)4.68630217
36fatty-acyl-CoA biosynthetic process (GO:0046949)4.52373007
37carnitine transmembrane transport (GO:1902603)4.52236539
38opsonization (GO:0008228)4.51478177
39glycerophospholipid catabolic process (GO:0046475)4.48025773
40protein localization to kinetochore (GO:0034501)4.45805344
41regulation of steroid hormone secretion (GO:2000831)4.44718389
42positive regulation of cellular amine metabolic process (GO:0033240)4.44472676
43regulation of hypersensitivity (GO:0002883)4.44281977
44intestinal epithelial cell development (GO:0060576)4.43488661
45positive regulation of intracellular steroid hormone receptor signaling pathway (GO:0033145)4.40181656
46neurofilament cytoskeleton organization (GO:0060052)4.39847054
47attachment of spindle microtubules to kinetochore (GO:0008608)4.39036530
48protein homotrimerization (GO:0070207)4.38188435
49regulation of chemokine secretion (GO:0090196)4.36610298
50acetyl-CoA metabolic process (GO:0006084)4.33373472
51regulation of histone H3-K27 methylation (GO:0061085)4.31077838
52mitotic cell cycle arrest (GO:0071850)4.26739358
53multicellular organism reproduction (GO:0032504)4.23158998
54one-carbon metabolic process (GO:0006730)4.13764104
55phospholipid scrambling (GO:0017121)4.12254196
56citrulline biosynthetic process (GO:0019240)4.10586617
57acyl-CoA biosynthetic process (GO:0071616)4.08773317
58thioester biosynthetic process (GO:0035384)4.08773317
59regulation of peroxisome proliferator activated receptor signaling pathway (GO:0035358)4.07708486
60regulation of Arp2/3 complex-mediated actin nucleation (GO:0034315)4.05425539
61amino-acid betaine transport (GO:0015838)4.05027781
62carnitine transport (GO:0015879)4.05027781
63epithelial cell differentiation involved in prostate gland development (GO:0060742)4.04127440
64DNA methylation involved in gamete generation (GO:0043046)4.03202655
65positive regulation of keratinocyte differentiation (GO:0045618)4.03184151
66retinal metabolic process (GO:0042574)4.01296791
67lung epithelial cell differentiation (GO:0060487)4.01227607
68S-adenosylmethionine metabolic process (GO:0046500)4.00731053
69fatty acid transmembrane transport (GO:1902001)4.00429571
70long-chain fatty acid biosynthetic process (GO:0042759)3.98442538
71pharyngeal system development (GO:0060037)3.96775198
72glucocorticoid receptor signaling pathway (GO:0042921)3.96121218
73regulation of viral entry into host cell (GO:0046596)3.95368255
74DNA damage induced protein phosphorylation (GO:0006975)3.92679788
75erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)3.91746747
76L-phenylalanine catabolic process (GO:0006559)3.91746747
77protein localization to chromosome, centromeric region (GO:0071459)3.88235966
78base-excision repair, AP site formation (GO:0006285)3.88038439
79metaphase plate congression (GO:0051310)3.87463112
80lung cell differentiation (GO:0060479)3.87157268
81oocyte maturation (GO:0001556)3.84835910
82histone H2A ubiquitination (GO:0033522)3.84447234
83cysteine metabolic process (GO:0006534)3.83998298
84fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)3.83513414
85toxin transport (GO:1901998)3.80876462
86quaternary ammonium group transport (GO:0015697)3.78021277
87lipoxygenase pathway (GO:0019372)3.75333705
88regulation of fatty acid beta-oxidation (GO:0031998)3.73898750
89histone H2A monoubiquitination (GO:0035518)3.70340885
90negative regulation of retinoic acid receptor signaling pathway (GO:0048387)3.70143348
91urea metabolic process (GO:0019627)3.64579614
92urea cycle (GO:0000050)3.64579614
93regulation of sensory perception (GO:0051931)3.63805108
94regulation of sensory perception of pain (GO:0051930)3.63805108
95response to testosterone (GO:0033574)3.61949408
96regulation of insulin-like growth factor receptor signaling pathway (GO:0043567)3.60359343
97L-phenylalanine metabolic process (GO:0006558)3.57519932
98erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)3.57519932
99long-chain fatty-acyl-CoA metabolic process (GO:0035336)3.56281419
100fibrinolysis (GO:0042730)3.55610432
101very-low-density lipoprotein particle assembly (GO:0034379)3.55333464
102lung lobe morphogenesis (GO:0060463)3.55296247
103negative regulation of reproductive process (GO:2000242)3.55055866
104regulation of macrophage cytokine production (GO:0010935)3.52035460
105positive regulation of humoral immune response (GO:0002922)3.44315535
106negative regulation of fatty acid transport (GO:2000192)3.43890645
107regulation of exit from mitosis (GO:0007096)3.43730338
108negative regulation of transcription elongation from RNA polymerase II promoter (GO:0034244)3.43718231
109negative regulation of DNA-templated transcription, elongation (GO:0032785)3.43718231
110establishment of spindle localization (GO:0051293)3.43179341
111male meiosis (GO:0007140)3.39124436
112sulfur amino acid catabolic process (GO:0000098)3.37943693
113regulation of attachment of spindle microtubules to kinetochore (GO:0051988)3.37577193
114chaperone-mediated protein transport (GO:0072321)3.36878544
115pyrimidine deoxyribonucleotide catabolic process (GO:0009223)3.34196893
116negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)3.33718611
117positive regulation of megakaryocyte differentiation (GO:0045654)3.31470840
118notochord development (GO:0030903)3.30485354
119protein localization to chromosome (GO:0034502)3.28949841
120nitrogen cycle metabolic process (GO:0071941)3.28281589
121reproduction (GO:0000003)3.26899489
122positive regulation of transcription from RNA polymerase III promoter (GO:0045945)3.25842085
123establishment of chromosome localization (GO:0051303)3.25430891
124aromatic amino acid family catabolic process (GO:0009074)3.25316613
125cellular ketone body metabolic process (GO:0046950)3.24391597
126positive regulation of inflammatory response to antigenic stimulus (GO:0002863)3.22747156
127establishment of spindle orientation (GO:0051294)3.20652503
128cytoskeletal anchoring at plasma membrane (GO:0007016)3.20468113
129insulin-like growth factor receptor signaling pathway (GO:0048009)3.17301821
130regulation of sister chromatid cohesion (GO:0007063)3.16732620
131folic acid-containing compound biosynthetic process (GO:0009396)3.16082821
132negative regulation of smooth muscle cell differentiation (GO:0051151)3.14988275
133drug catabolic process (GO:0042737)3.14416874
134COPI coating of Golgi vesicle (GO:0048205)3.12092943
135Golgi transport vesicle coating (GO:0048200)3.12092943
136polyamine biosynthetic process (GO:0006596)3.12004486
137oocyte development (GO:0048599)3.11694954
138fat-soluble vitamin biosynthetic process (GO:0042362)3.11483335
139coenzyme A metabolic process (GO:0015936)3.11252360
140regulation of spindle organization (GO:0090224)3.11192583
141regulation of RIG-I signaling pathway (GO:0039535)3.10810104
142folic acid metabolic process (GO:0046655)3.09909705
143fatty-acyl-CoA metabolic process (GO:0035337)3.09019228
144coenzyme A biosynthetic process (GO:0015937)3.07859849
145corticosteroid receptor signaling pathway (GO:0031958)3.07738225
146regulation of ARF protein signal transduction (GO:0032012)3.06904059
147regulation of mitotic spindle organization (GO:0060236)3.06184084
148myelin maintenance (GO:0043217)3.06001343
149lung secretory cell differentiation (GO:0061140)3.05396362
150regulation of protein polyubiquitination (GO:1902914)3.03358248
151apical protein localization (GO:0045176)3.02597059
152microtubule severing (GO:0051013)3.02292683
153regulation of tight junction assembly (GO:2000810)3.01868683
154gene silencing by RNA (GO:0031047)3.00370222
155regulation of meiosis I (GO:0060631)2.99299279
156regulation of actin nucleation (GO:0051125)2.99135918
157peroxisome fission (GO:0016559)2.98923091
158cellular modified amino acid biosynthetic process (GO:0042398)2.94644208
159positive regulation of Cdc42 GTPase activity (GO:0043089)2.94129942
160regulation of retinoic acid receptor signaling pathway (GO:0048385)2.92439898
161cell-cell junction maintenance (GO:0045217)2.90693354
162regulation of acute inflammatory response to antigenic stimulus (GO:0002864)2.89837126
163copper ion transport (GO:0006825)2.89732816
164response to misfolded protein (GO:0051788)2.87478530
165CENP-A containing nucleosome assembly (GO:0034080)2.87103007
166regulation of metaphase/anaphase transition of cell cycle (GO:1902099)2.86900849
167COPII vesicle coating (GO:0048208)2.84746081
168regulation of fatty acid oxidation (GO:0046320)2.84510330
169positive regulation of chromosome segregation (GO:0051984)2.83638160
170bile acid biosynthetic process (GO:0006699)2.83622783
171regulation of cell-cell adhesion mediated by cadherin (GO:2000047)2.83536285
172embryonic retina morphogenesis in camera-type eye (GO:0060059)2.82208095
173pyrimidine nucleotide catabolic process (GO:0006244)2.82107837
174mitotic sister chromatid segregation (GO:0000070)2.81647189
175regulation of transforming growth factor beta2 production (GO:0032909)2.81119224
176lysine catabolic process (GO:0006554)2.80958928
177lysine metabolic process (GO:0006553)2.80958928
178retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)2.78404824
179urate metabolic process (GO:0046415)2.77423246
180regulation of reproductive process (GO:2000241)2.76578165
181synaptic vesicle docking involved in exocytosis (GO:0016081)2.76439405
182regulation of phospholipid biosynthetic process (GO:0071071)2.76316574
183ruffle organization (GO:0031529)2.75769388
184positive regulation of myeloid leukocyte cytokine production involved in immune response (GO:00610812.75520885
185ketone body metabolic process (GO:1902224)2.74179444
186muscle cell migration (GO:0014812)2.74054963
187endothelium development (GO:0003158)2.73979840
188regulation of endocrine process (GO:0044060)2.73780037
189regulation of cholesterol metabolic process (GO:0090181)2.72869410
190negative regulation of cell size (GO:0045792)2.72791983
191maturation of 5.8S rRNA (GO:0000460)2.71508395
192glandular epithelial cell differentiation (GO:0002067)2.71489099
193sulfur amino acid metabolic process (GO:0000096)2.71140173
194chromatin remodeling at centromere (GO:0031055)2.70664200
195negative regulation of execution phase of apoptosis (GO:1900118)2.70436606
196alpha-linolenic acid metabolic process (GO:0036109)2.69717910
197positive regulation of epidermal cell differentiation (GO:0045606)2.67603302
198negative regulation of protein localization to cell surface (GO:2000009)2.66309326
199regulation of female gonad development (GO:2000194)10.9409380

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1ESR1_17901129_ChIP-ChIP_LIVER_Mouse5.38442235
2BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse5.36572491
3AR_21909140_ChIP-Seq_LNCAP_Human4.15627780
4PIAS1_25552417_ChIP-Seq_VCAP_Human4.10206792
5FOXM1_23109430_ChIP-Seq_U2OS_Human4.08999593
6* RXR_22158963_ChIP-Seq_LIVER_Mouse4.08217364
7KAP1_22055183_ChIP-Seq_ESCs_Mouse3.43671218
8EGR1_23403033_ChIP-Seq_LIVER_Mouse3.41650608
9FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human3.35566960
10* LXR_22158963_ChIP-Seq_LIVER_Mouse3.16616154
11PPARA_22158963_ChIP-Seq_LIVER_Mouse3.01785903
12TFAP2C_20629094_ChIP-Seq_MCF-7_Human2.78223647
13TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse2.77068879
14CEBPB_23403033_ChIP-Seq_LIVER_Mouse2.43162870
15STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse2.37667027
16RACK7_27058665_Chip-Seq_MCF-7_Human2.35746993
17NANOG_18700969_ChIP-ChIP_MESCs_Mouse2.22815367
18* CHD1_26751641_Chip-Seq_LNCaP_Human2.16375393
19SALL1_21062744_ChIP-ChIP_HESCs_Human2.11620209
20CREB1_26743006_Chip-Seq_LNCaP_Human2.11207278
21CHD7_19251738_ChIP-ChIP_MESCs_Mouse2.00563977
22MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.99740505
23MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.98852354
24* EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.98148127
25ZNF263_19887448_ChIP-Seq_K562_Human1.97557653
26* TCF7_22412390_ChIP-Seq_EML_Mouse1.97005720
27PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.96126456
28* CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.95002168
29VDR_21846776_ChIP-Seq_THP-1_Human1.87800893
30AR_21572438_ChIP-Seq_LNCaP_Human1.84745833
31GATA1_26923725_Chip-Seq_HPCs_Mouse1.82465773
32STAT6_21828071_ChIP-Seq_BEAS2B_Human1.81163992
33ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.79684755
34NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.76968383
35* LXR_22292898_ChIP-Seq_THP-1_Human1.76727516
36KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.75253686
37RUNX1_27514584_Chip-Seq_MCF-7_Human1.73926492
38MYC_18940864_ChIP-ChIP_HL60_Human1.73596178
39MYC_22102868_ChIP-Seq_BL_Human1.68792697
40RUNX1_26923725_Chip-Seq_HPCs_Mouse1.65393256
41FOXO3_23340844_ChIP-Seq_DLD1_Human1.63855659
42AUTS2_25519132_ChIP-Seq_293T-REX_Human1.59022443
43FOXM1_26456572_ChIP-Seq_MCF-7_Human1.57662837
44CDX2_22108803_ChIP-Seq_LS180_Human1.57276506
45SALL4_18804426_ChIP-ChIP_XEN_Mouse1.56908937
46VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.54440802
47DROSHA_22980978_ChIP-Seq_HELA_Human1.53372757
48SOX9_24532713_ChIP-Seq_HFSC_Mouse1.51316076
49ESR1_21235772_ChIP-Seq_MCF-7_Human1.48884326
50* ELK3_25401928_ChIP-Seq_HUVEC_Human1.48713158
51ESR1_20079471_ChIP-ChIP_T-47D_Human1.46471140
52ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.46066734
53SMAD_19615063_ChIP-ChIP_OVARY_Human1.45859948
54GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.45571365
55MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.44916706
56FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.44562481
57* KDM2B_26808549_Chip-Seq_SUP-B15_Human1.43679139
58ERG_20517297_ChIP-Seq_VCAP_Human1.42976784
59KDM2B_26808549_Chip-Seq_K562_Human1.42730315
60* SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.39888171
61CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.37021242
62ERG_21242973_ChIP-ChIP_JURKAT_Human1.36706563
63* KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.36663221
64CLOCK_20551151_ChIP-Seq_293T_Human1.34769567
65* VDR_24763502_ChIP-Seq_THP-1_Human1.34387506
66AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.33961484
67SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.31927695
68FOXA1_26743006_Chip-Seq_LNCaP-abl_Human1.30782087
69PPAR_26484153_Chip-Seq_NCI-H1993_Human1.30415937
70PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.29892230
71ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.29158323
72NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.28938662
73SMC4_20622854_ChIP-Seq_HELA_Human1.27432494
74CDX2_19796622_ChIP-Seq_MESCs_Mouse1.26370274
75FOXA2_19822575_ChIP-Seq_HepG2_Human1.26295886
76KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.25754562
77ESR2_21235772_ChIP-Seq_MCF-7_Human1.24400303
78ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.23537713
79SOX2_19030024_ChIP-ChIP_MESCs_Mouse1.22175314
80SPI1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.21428590
81CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.21284476
82SCL_19346495_ChIP-Seq_HPC-7_Human1.21229732
83NANOG_20526341_ChIP-Seq_ESCs_Human1.20304996
84KDM2B_26808549_Chip-Seq_DND41_Human1.20135543
85PKCTHETA_26484144_Chip-Seq_BREAST_Human1.19682536
86FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.17782604
87TP63_17297297_ChIP-ChIP_HaCaT_Human1.17628459
88* WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.16964027
89* NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.16219204
90STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.16114120
91STAT1_17558387_ChIP-Seq_HELA_Human1.15850765
92FOXH1_21741376_ChIP-Seq_EPCs_Human1.15380888
93GATA2_21666600_ChIP-Seq_HMVEC_Human1.15279928
94DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.14734716
95EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.13621843
96PPARG_20176806_ChIP-Seq_3T3-L1_Mouse1.13126304
97FLI1_27457419_Chip-Seq_LIVER_Mouse1.12956495
98ESET_19884257_ChIP-Seq_ESCs_Mouse1.11673546
99NANOG_21062744_ChIP-ChIP_HESCs_Human1.11424993
100* FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human1.11208536
101* FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human1.09740135
102GATA4_25053715_ChIP-Seq_YYC3_Human1.09664068
103LMO2_26923725_Chip-Seq_MACROPHAGESS_Mouse1.09553523
104P300_27058665_Chip-Seq_ZR-75-30cells_Human1.09282390
105* TP63_23658742_ChIP-Seq_EP156T_Human1.07934955
106NFIB_24661679_ChIP-Seq_LUNG_Mouse1.07047550
107CTNNB1_20460455_ChIP-Seq_HCT116_Human1.06615195
108GATA3_21867929_ChIP-Seq_TH1_Mouse1.05920935
109HIF1A_21447827_ChIP-Seq_MCF-7_Human1.05230809
110PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.04714715
111KDM2B_26808549_Chip-Seq_JURKAT_Human1.04597269
112TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.04357791
113TBX5_21415370_ChIP-Seq_HL-1_Mouse1.03878033
114NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.01281393
115E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse0.98878160
116KLF5_18264089_ChIP-ChIP_MESCs_Mouse0.97646068
117KLF4_18264089_ChIP-ChIP_MESCs_Mouse0.97646068
118KLF2_18264089_ChIP-ChIP_MESCs_Mouse0.97646068
119GATA3_26560356_Chip-Seq_TH1_Human0.97241809
120EZH2_22144423_ChIP-Seq_EOC_Human0.96900559
121* KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human0.96171088
122* NFYA_21822215_ChIP-Seq_K562_Human0.95722454
123* HNF4A_19822575_ChIP-Seq_HepG2_Human0.95476701
124TFAP2A_17053090_ChIP-ChIP_MCF-7_Human0.95181312
125GATA1_19941827_ChIP-Seq_MEL_Mouse0.94712203
126EGR1_19374776_ChIP-ChIP_THP-1_Human0.93656898
127* GATA6_25053715_ChIP-Seq_YYC3_Human0.93452572
128MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse0.93229612
129FOXA1_25552417_ChIP-Seq_VCAP_Human0.92980282
130SETDB1_19884257_ChIP-Seq_MESCs_Mouse0.92973925
131SMAD4_21741376_ChIP-Seq_EPCs_Human0.92306434
132PPARD_23208498_ChIP-Seq_MDA-MB-231_Human0.92203675
133VDR_22108803_ChIP-Seq_LS180_Human0.92118412
134* CEBPB_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.92043679
135OCT1_27270436_Chip-Seq_PROSTATE_Human0.91861266
136EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human0.91835801
137ELK4_26923725_Chip-Seq_MESODERM_Mouse0.90781877
138* GATA1_19941826_ChIP-Seq_K562_Human0.90632023
139FOXA1_21572438_ChIP-Seq_LNCaP_Human0.90412348
140CJUN_26792858_Chip-Seq_BT549_Human0.89834405
141TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.89480712
142KDM5A_27292631_Chip-Seq_BREAST_Human0.89353829
143* AR_21915096_ChIP-Seq_LNCaP-1F5_Human0.88132087
144TP63_22573176_ChIP-Seq_HFKS_Human0.87951451
145HNFA_21074721_ChIP-Seq_CACO-2_Human0.87215681
146ESR1_22446102_ChIP-Seq_UTERUS_Mouse0.87006018
147AHR_22903824_ChIP-Seq_MCF-7_Human0.86947967
148TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse0.86332874
149* CTCF_27219007_Chip-Seq_ERYTHROID_Human0.86181241
150CDX2_20551321_ChIP-Seq_CACO-2_Human0.85982923
151GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.85940026
152CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.83864372
153GF1B_26923725_Chip-Seq_HPCs_Mouse0.82077679
154SMARCD1_25818293_ChIP-Seq_ESCs_Mouse0.81397785
155GATA3_24758297_ChIP-Seq_MCF-7_Human0.80999133
156STAT3_23295773_ChIP-Seq_U87_Human0.80918191
157NANOG_18347094_ChIP-ChIP_MESCs_Mouse0.80678884
158GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse0.80447393
159ATF3_27146783_Chip-Seq_COLON_Human0.79810510
160* GATA6_21074721_ChIP-Seq_CACO-2_Mouse0.79634008
161SOX2_27498859_Chip-Seq_STOMACH_Mouse0.79554169
162MEF2A_21415370_ChIP-Seq_HL-1_Mouse0.78403311
163TBL1_22424771_ChIP-Seq_293T_Human0.78146020
164ZNF217_24962896_ChIP-Seq_MCF-7_Human0.77995559
165EP300_21415370_ChIP-Seq_HL-1_Mouse0.77595445
166TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse0.76827272
167TCF3_18467660_ChIP-ChIP_MESCs_Mouse0.76040497
168* E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human0.75559112
169* CEBPB_22108803_ChIP-Seq_LS180_Human0.75197549
170FLI1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.73921540
171OCT4_20526341_ChIP-Seq_ESCs_Human0.73594483

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005451_abnormal_body_composition6.31701843
2MP0003718_maternal_effect6.28228991
3MP0002139_abnormal_hepatobiliary_system4.76050995
4MP0004858_abnormal_nervous_system4.37889877
5MP0005360_urolithiasis4.30034809
6MP0002166_altered_tumor_susceptibility4.28827075
7MP0003011_delayed_dark_adaptation3.88691435
8MP0005167_abnormal_blood-brain_barrier3.74852409
9MP0002822_catalepsy3.72881992
10MP0003646_muscle_fatigue3.49435987
11MP0002736_abnormal_nociception_after3.29930031
12MP0002234_abnormal_pharynx_morphology3.14030364
13MP0005645_abnormal_hypothalamus_physiol3.01389906
14MP0002006_tumorigenesis3.00735808
15MP0005395_other_phenotype2.98384305
16MP0005365_abnormal_bile_salt2.94307544
17MP0008875_abnormal_xenobiotic_pharmacok2.88573182
18MP0003806_abnormal_nucleotide_metabolis2.83687604
19MP0008961_abnormal_basal_metabolism2.82048283
20MP0005085_abnormal_gallbladder_physiolo2.79592870
21MP0002735_abnormal_chemical_nociception2.77506523
22MP0003699_abnormal_female_reproductive2.74829534
23MP0002653_abnormal_ependyma_morphology2.73812294
24MP0009840_abnormal_foam_cell2.68380400
25MP0001873_stomach_inflammation2.64614431
26MP0001119_abnormal_female_reproductive2.62965899
27MP0002009_preneoplasia2.61782974
28MP0010234_abnormal_vibrissa_follicle2.58497142
29MP0005670_abnormal_white_adipose2.48878681
30MP0000537_abnormal_urethra_morphology2.37831282
31MP0005076_abnormal_cell_differentiation2.26101803
32MP0002102_abnormal_ear_morphology2.19878182
33MP0004510_myositis2.17343246
34MP0005408_hypopigmentation2.12439233
35MP0000579_abnormal_nail_morphology2.12246530
36MP0003693_abnormal_embryo_hatching2.06795021
37MP0010094_abnormal_chromosome_stability2.05606637
38MP0005666_abnormal_adipose_tissue1.93776862
39MP0000653_abnormal_sex_gland1.92646080
40MP0004264_abnormal_extraembryonic_tissu1.90899539
41MP0001929_abnormal_gametogenesis1.90880782
42MP0001968_abnormal_touch/_nociception1.89250478
43MP0001664_abnormal_digestion1.87716370
44MP0002295_abnormal_pulmonary_circulatio1.87383665
45MP0008260_abnormal_autophagy1.87185755
46MP0000613_abnormal_salivary_gland1.84517816
47MP0004145_abnormal_muscle_electrophysio1.83001289
48MP0008877_abnormal_DNA_methylation1.78662768
49MP0003252_abnormal_bile_duct1.70878378
50MP0003111_abnormal_nucleus_morphology1.66307343
51MP0000538_abnormal_urinary_bladder1.65304851
52MP0001915_intracranial_hemorrhage1.61176456
53MP0004947_skin_inflammation1.57678986
54MP0003656_abnormal_erythrocyte_physiolo1.54589485
55MP0003879_abnormal_hair_cell1.53888786
56MP0005647_abnormal_sex_gland1.53022144
57MP0003045_fibrosis1.52461195
58MP0005332_abnormal_amino_acid1.48603917
59MP0003077_abnormal_cell_cycle1.48459197
60MP0002210_abnormal_sex_determination1.39343981
61MP0010329_abnormal_lipoprotein_level1.37733492
62MP0002161_abnormal_fertility/fecundity1.34493226
63MP0001905_abnormal_dopamine_level1.33848953
64MP0005310_abnormal_salivary_gland1.33754411
65MP0003950_abnormal_plasma_membrane1.33752334
66MP0004036_abnormal_muscle_relaxation1.29475569
67MP0001666_abnormal_nutrient_absorption1.25285213
68MP0003566_abnormal_cell_adhesion1.25002620
69MP0003705_abnormal_hypodermis_morpholog1.23528771
70MP0004957_abnormal_blastocyst_morpholog1.23029256
71MP0004185_abnormal_adipocyte_glucose1.22754932
72MP0005367_renal/urinary_system_phenotyp1.21888772
73MP0000516_abnormal_urinary_system1.21888772
74MP0000639_abnormal_adrenal_gland1.21204701
75MP0003937_abnormal_limbs/digits/tail_de1.20157857
76MP0010678_abnormal_skin_adnexa1.16162994
77MP0003329_amyloid_beta_deposits1.15919164
78MP0003453_abnormal_keratinocyte_physiol1.15624607
79MP0002733_abnormal_thermal_nociception1.12721060
80MP0001529_abnormal_vocalization1.08827933
81MP0003191_abnormal_cellular_cholesterol1.08637969
82MP0005375_adipose_tissue_phenotype1.08488589
83MP0010368_abnormal_lymphatic_system1.08254994
84MP0003195_calcinosis1.08112170
85MP0009384_cardiac_valve_regurgitation1.07550906
86MP0000609_abnormal_liver_physiology1.05961600
87MP0003866_abnormal_defecation1.01545095
88MP0000230_abnormal_systemic_arterial1.00275205
89MP0002909_abnormal_adrenal_gland0.99103868
90MP0000465_gastrointestinal_hemorrhage0.95809481
91MP0001919_abnormal_reproductive_system0.95315113
92MP0000427_abnormal_hair_cycle0.94438960
93MP0002249_abnormal_larynx_morphology0.94149275
94MP0000462_abnormal_digestive_system0.92825580
95MP0000604_amyloidosis0.92070744
96MP0000534_abnormal_ureter_morphology0.91923910
97MP0001145_abnormal_male_reproductive0.91181215
98MP0006072_abnormal_retinal_apoptosis0.91106477
99MP0003186_abnormal_redox_activity0.89384630
100MP0002118_abnormal_lipid_homeostasis0.88543052
101MP0002693_abnormal_pancreas_physiology0.88492325
102MP0008932_abnormal_embryonic_tissue0.86637358
103MP0001346_abnormal_lacrimal_gland0.86055138
104MP0000678_abnormal_parathyroid_gland0.85318981
105MP0001485_abnormal_pinna_reflex0.85275897
106MP0002932_abnormal_joint_morphology0.83900085
107MP0004233_abnormal_muscle_weight0.83168635
108MP0003868_abnormal_feces_composition0.82702989
109MP0005409_darkened_coat_color0.82106791
110MP0001849_ear_inflammation0.80869313
111MP0002078_abnormal_glucose_homeostasis0.80368893
112MP0000733_abnormal_muscle_development0.79854411
113MP0009697_abnormal_copulation0.79749916
114MP0000432_abnormal_head_morphology0.78041374
115MP0005636_abnormal_mineral_homeostasis0.77803370
116MP0005448_abnormal_energy_balance0.76663241
117MP0002019_abnormal_tumor_incidence0.76581438
118MP0001765_abnormal_ion_homeostasis0.75713449
119MP0000477_abnormal_intestine_morphology0.75433125
120MP0005381_digestive/alimentary_phenotyp0.74390031
121MP0003633_abnormal_nervous_system0.73347737
122MP0009643_abnormal_urine_homeostasis0.72957817
123MP0001730_embryonic_growth_arrest0.72891976
124MP0002108_abnormal_muscle_morphology0.72768796
125MP0003091_abnormal_cell_migration0.71933853
126MP0000566_synostosis0.71812044
127MP0003315_abnormal_perineum_morphology0.71302227
128MP0005197_abnormal_uvea_morphology0.70794780
129MP0001501_abnormal_sleep_pattern0.70055459
130MP0003953_abnormal_hormone_level0.69480400
131MP0001970_abnormal_pain_threshold0.69326336
132MP0010386_abnormal_urinary_bladder0.68526352
133MP0002090_abnormal_vision0.65812367
134MP0004808_abnormal_hematopoietic_stem0.65754927
135MP0005389_reproductive_system_phenotype0.65618868
136MP0000627_abnormal_mammary_gland0.65546091
137MP0005023_abnormal_wound_healing0.65103910
138MP0001764_abnormal_homeostasis0.63375328
139MP0002089_abnormal_postnatal_growth/wei0.63027083
140MP0002085_abnormal_embryonic_tissue0.62492623
141MP0002138_abnormal_hepatobiliary_system0.62443261
142MP0000350_abnormal_cell_proliferation0.61403319
143MP0009763_increased_sensitivity_to0.60252661
144MP0001756_abnormal_urination0.59925167
145MP0004019_abnormal_vitamin_homeostasis0.59783398
146MP0004043_abnormal_pH_regulation0.59573378
147MP0001731_abnormal_postnatal_growth0.59495222
148MP0003283_abnormal_digestive_organ0.58267956
149MP0002168_other_aberrant_phenotype0.57789098
150MP0005187_abnormal_penis_morphology0.57258397
151MP0002136_abnormal_kidney_physiology0.56578346
152MP0002796_impaired_skin_barrier0.56577929
153MP0005646_abnormal_pituitary_gland0.56132350
154MP0000598_abnormal_liver_morphology0.55665717
155MP0003942_abnormal_urinary_system0.55245226
156MP0009703_decreased_birth_body0.55165848
157MP0001944_abnormal_pancreas_morphology0.55057496
158MP0005058_abnormal_lysosome_morphology0.52809204
159MP0001697_abnormal_embryo_size0.52729675
160MP0005330_cardiomyopathy0.52693453
161MP0005083_abnormal_biliary_tract0.52417418
162MP0005220_abnormal_exocrine_pancreas0.51539999
163MP0000920_abnormal_myelination0.51411424
164MP0009765_abnormal_xenobiotic_induced0.50154981
165MP0003631_nervous_system_phenotype0.49855823
166MP0001663_abnormal_digestive_system0.49833987
167MP0005623_abnormal_meninges_morphology0.49817835
168MP0005319_abnormal_enzyme/_coenzyme0.49790691
169MP0000383_abnormal_hair_follicle0.49506212
170MP0000470_abnormal_stomach_morphology0.48594602
171MP0010155_abnormal_intestine_physiology0.48515748
172MP0005621_abnormal_cell_physiology0.46918257
173MP0006292_abnormal_olfactory_placode0.46658267
174MP0010630_abnormal_cardiac_muscle0.46352542
175MP0002971_abnormal_brown_adipose0.45875129

Predicted human phenotypes

RankGene SetZ-score
1Deep venous thrombosis (HP:0002625)9.22441657
2Male infertility (HP:0003251)7.93828205
3Amelogenesis imperfecta (HP:0000705)5.64554641
4Flat acetabular roof (HP:0003180)5.54658587
5Broad face (HP:0000283)4.92332527
6Intrahepatic cholestasis (HP:0001406)4.75443958
7Aortic aneurysm (HP:0004942)4.71585780
8Abnormal tarsal ossification (HP:0008369)4.70351891
9Premature ovarian failure (HP:0008209)4.68443896
10Abnormality of the distal phalanx of the thumb (HP:0009617)4.64389847
11Abnormal gallbladder physiology (HP:0012438)4.26237804
12Cholecystitis (HP:0001082)4.26237804
13Aplasia/Hypoplasia of the 1st metacarpal (HP:0010026)4.20910008
14Short 1st metacarpal (HP:0010034)4.20910008
15Abnormality of the 1st metacarpal (HP:0010009)4.12018404
16Infertility (HP:0000789)4.07455152
17Abnormality of aromatic amino acid family metabolism (HP:0004338)4.05956506
18Neoplasm of the heart (HP:0100544)4.00045158
19Secondary amenorrhea (HP:0000869)3.92245273
20Abnormality of carpal bone ossification (HP:0006257)3.85068588
21Abnormality of the distal phalanges of the toes (HP:0010182)3.82522160
22Abnormality of the phalanges of the hallux (HP:0010057)3.79655798
23Breast hypoplasia (HP:0003187)3.77613678
24Abnormal foot bone ossification (HP:0010675)3.76859092
25Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)3.74644208
26Hypergonadotropic hypogonadism (HP:0000815)3.69257634
27Abnormal ossification of hand bones (HP:0005921)3.51088937
28Sparse lateral eyebrow (HP:0005338)3.48525984
29Cortical dysplasia (HP:0002539)3.47844120
30Short phalanx of the thumb (HP:0009660)3.47169186
31Birth length less than 3rd percentile (HP:0003561)3.44533462
32Bronchomalacia (HP:0002780)3.41641250
33Flattened epiphyses (HP:0003071)3.41583889
34Myokymia (HP:0002411)3.38700473
35Abnormal hand bone ossification (HP:0010660)3.34463267
36Obstructive sleep apnea (HP:0002870)3.31075503
37Abnormality of the fingertips (HP:0001211)3.21644200
38Broad metatarsal (HP:0001783)3.06565118
39Hypobetalipoproteinemia (HP:0003563)3.05686257
40Xanthomatosis (HP:0000991)3.05013366
41Aortic dissection (HP:0002647)3.04380732
42Malnutrition (HP:0004395)3.04332250
43Adrenal hypoplasia (HP:0000835)3.04145273
44Abnormality of monocarboxylic acid metabolism (HP:0010996)3.03993048
45Abnormality of secondary sexual hair (HP:0009888)3.00956768
46Abnormality of the axillary hair (HP:0100134)3.00956768
47Abnormality of aspartate family amino acid metabolism (HP:0010899)2.94529037
48Abnormality of methionine metabolism (HP:0010901)2.91760644
49Rhabdomyosarcoma (HP:0002859)2.88446722
50Abnormality of sulfur amino acid metabolism (HP:0004339)2.84055102
51Short nail (HP:0001799)2.82894918
52Papillary thyroid carcinoma (HP:0002895)2.79512261
53Anal stenosis (HP:0002025)2.76385511
54Partial duplication of thumb phalanx (HP:0009944)2.72596084
55Dysmetric saccades (HP:0000641)2.71051117
56Abnormality of cochlea (HP:0000375)2.70923001
57Septate vagina (HP:0001153)2.70377630
58Segmental peripheral demyelination/remyelination (HP:0003481)2.66708742
59Axonal loss (HP:0003447)2.66213333
60Aplasia/Hypoplasia of the phalanges of the thumb (HP:0009658)2.64876788
61Shawl scrotum (HP:0000049)2.61308627
62Shallow orbits (HP:0000586)2.60798284
63Fat malabsorption (HP:0002630)2.58890411
64Aortic regurgitation (HP:0001659)2.58736595
65Abnormality of the proximal phalanges of the hand (HP:0009834)2.58259453
66Chromsome breakage (HP:0040012)2.57852439
67Aplasia/hypoplasia of the femur (HP:0005613)2.56617922
68Congenital glaucoma (HP:0001087)2.53567940
69Spontaneous abortion (HP:0005268)2.52438118
70Advanced eruption of teeth (HP:0006288)2.50595757
71Hyperammonemia (HP:0001987)2.49148241
72Abnormality of lateral ventricle (HP:0030047)2.49145260
73Hyperlipoproteinemia (HP:0010980)2.45772864
74Abnormality of placental membranes (HP:0011409)2.45029887
75Amniotic constriction ring (HP:0009775)2.45029887
76Hypolipoproteinemia (HP:0010981)2.44669287
77Germ cell neoplasia (HP:0100728)2.44523139
78Complement deficiency (HP:0004431)2.43509812
79Aplasia/Hypoplasia involving the musculature (HP:0001460)2.39392614
80Overlapping toe (HP:0001845)2.37858086
81Arterial tortuosity (HP:0005116)2.37752653
82Cervical subluxation (HP:0003308)2.37579036
83Prolonged partial thromboplastin time (HP:0003645)2.33452834
84Flat capital femoral epiphysis (HP:0003370)2.32357846
85Severe short stature (HP:0003510)2.31999509
86Renal tubular acidosis (HP:0001947)2.31305457
87Hypoalphalipoproteinemia (HP:0003233)2.30999964
88Ureteral stenosis (HP:0000071)2.30159250
89Laryngomalacia (HP:0001601)2.26137582
90Steatorrhea (HP:0002570)2.24751041
91Gastrointestinal dysmotility (HP:0002579)2.24307369
92Chromosomal breakage induced by crosslinking agents (HP:0003221)2.23732893
93Microretrognathia (HP:0000308)2.23354379
94Hyperglycinemia (HP:0002154)2.22956548
95Abnormality of fatty-acid metabolism (HP:0004359)2.22763891
96Ureteral obstruction (HP:0006000)2.22296517
97Gout (HP:0001997)2.21926473
98Stroke (HP:0001297)2.21877454
99Abnormality of the labia minora (HP:0012880)2.21409125
100Partial duplication of the phalanx of hand (HP:0009999)2.20115748
101Abnormality of long-chain fatty-acid metabolism (HP:0010964)2.18853228
102Abnormality of the parathyroid morphology (HP:0011766)2.18801610
103Brushfield spots (HP:0001088)2.18025339
104Tracheomalacia (HP:0002779)2.14260393
105Aplasia of the phalanges of the hand (HP:0009802)2.14240922
106Aplasia involving bones of the extremities (HP:0009825)2.14240922
107Aplasia involving bones of the upper limbs (HP:0009823)2.14240922
108Urethral obstruction (HP:0000796)2.13980986
109Combined immunodeficiency (HP:0005387)2.13906404
110Genetic anticipation (HP:0003743)2.13667054
111Vascular tortuosity (HP:0004948)2.13584172
112Abnormality of glycine metabolism (HP:0010895)2.12576198
113Abnormality of serine family amino acid metabolism (HP:0010894)2.12576198
114Abnormality of serum amino acid levels (HP:0003112)2.12554988
115Aplasia/Hypoplasia of the sternum (HP:0006714)2.12118064
116Abnormality of the level of lipoprotein cholesterol (HP:0010979)2.11213685
117Hyperglycinuria (HP:0003108)2.08950186
118Lip pit (HP:0100267)2.07848254
119Aplasia/Hypoplasia of the breasts (HP:0010311)2.07254773
120Abnormality of purine metabolism (HP:0004352)2.05332581
121Right ventricular cardiomyopathy (HP:0011663)2.04841852
122Ketosis (HP:0001946)2.04528100
123Abnormality of the nasal septum (HP:0000419)2.04307414
124Abnormality of abdominal situs (HP:0011620)2.04263495
125Abdominal situs inversus (HP:0003363)2.04263495
126Abnormality of nucleobase metabolism (HP:0010932)2.03435811
127Breast aplasia (HP:0100783)2.03435060
128Aneurysm (HP:0002617)2.03215591
129Skin nodule (HP:0200036)2.02731080
130Seborrheic dermatitis (HP:0001051)2.01766915
131Facial hemangioma (HP:0000329)2.01295736
132Pulmonary fibrosis (HP:0002206)2.00660141
133Persistence of primary teeth (HP:0006335)2.00409097
134Acanthocytosis (HP:0001927)2.00358908
135Abnormality of pyrimidine metabolism (HP:0004353)1.99642270
136Bundle branch block (HP:0011710)1.99209091
137Abnormality of the common coagulation pathway (HP:0010990)1.98050593
138Abnormality of pyruvate family amino acid metabolism (HP:0010915)1.97230395
139Abnormality of alanine metabolism (HP:0010916)1.97230395
140Hyperalaninemia (HP:0003348)1.97230395
141Impaired smooth pursuit (HP:0007772)1.96832206
142Hyperparathyroidism (HP:0000843)1.95610328
143Spinal cord compression (HP:0002176)1.95456530
144Neoplasm of striated muscle (HP:0009728)1.95375574
145Abnormality of the Achilles tendon (HP:0005109)1.93904123
146Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)1.93642951
147Degeneration of the lateral corticospinal tracts (HP:0002314)1.93642951
148Fibular aplasia (HP:0002990)1.93259865
149Morphological abnormality of the inner ear (HP:0011390)1.92976912
150Testicular atrophy (HP:0000029)1.92643380
151Abnormal gallbladder morphology (HP:0012437)1.92586111
15211 pairs of ribs (HP:0000878)1.92360881
153Clitoromegaly (HP:0000057)1.92154588
154Patellar aplasia (HP:0006443)1.91715788
155Gaze-evoked nystagmus (HP:0000640)1.91230140
156Respiratory insufficiency due to defective ciliary clearance (HP:0200073)1.90997071
157Abnormality of chromosome segregation (HP:0002916)1.90129301
158Patellar dislocation (HP:0002999)1.90073358
159Cholelithiasis (HP:0001081)1.89410407
160Dysdiadochokinesis (HP:0002075)1.89290193
161Chronic bronchitis (HP:0004469)1.88485518
162Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)1.87032550
163Epidermoid cyst (HP:0200040)1.86235235
164Onion bulb formation (HP:0003383)1.85951165
165Neonatal hypoglycemia (HP:0001998)1.85334851
166Primary amenorrhea (HP:0000786)1.83492271
167Aplasia/Hypoplasia involving the femoral head and neck (HP:0009108)1.82938657
168Midface retrusion (HP:0011800)1.82619866
169Long eyelashes (HP:0000527)1.82083202
170Tetany (HP:0001281)1.81930691
171Overgrowth (HP:0001548)1.80612544
172Limb ataxia (HP:0002070)1.79402801
173Hyperuricemia (HP:0002149)1.79072624
174Increased purine levels (HP:0004368)1.79072624
175Insulin-resistant diabetes mellitus (HP:0000831)1.78075987
176Hyperglycemia (HP:0003074)1.78036163
177Short humerus (HP:0005792)1.78007499
178Carpal bone hypoplasia (HP:0001498)1.77602723
179Neurofibrillary tangles (HP:0002185)1.77064899
180Sandal gap (HP:0001852)1.76270213
181Abnormality of the middle phalanges of the toes (HP:0010183)1.76187605
182Tented upper lip vermilion (HP:0010804)1.76089777
183Amyloidosis (HP:0011034)1.76087908
184Hepatocellular carcinoma (HP:0001402)1.73705982
185Short femoral neck (HP:0100864)1.72821427
186Blue sclerae (HP:0000592)1.71742306
187Macroorchidism (HP:0000053)1.70389267
188Achilles tendon contracture (HP:0001771)1.70024631
189Abnormal cartilage morphology (HP:0002763)1.66911449
190Narrow palate (HP:0000189)1.64793994
191Lower limb hyperreflexia (HP:0002395)1.64761425
192Vertebral arch anomaly (HP:0008438)1.64547775
193Prostate neoplasm (HP:0100787)1.64132573
194Precocious puberty (HP:0000826)1.62076379
195Abnormality of saccadic eye movements (HP:0000570)1.61858858

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CAMK1D7.79792152
2CAMK1G6.02922204
3MOS5.89836784
4BMPR25.82904963
5TAOK35.82436104
6AKT35.08454052
7LATS13.84250149
8MAP3K63.30075088
9TTK3.05312647
10KSR22.89173560
11LATS22.80590593
12ERBB42.53162956
13MAP3K92.46870458
14MAP3K132.37582744
15STK38L2.36856696
16PLK42.34335244
17TNK22.20146077
18MYLK2.12159827
19STK102.11805402
20BRAF2.09047569
21ARAF2.07397205
22SMG11.96364333
23EEF2K1.87463642
24CDK121.83311600
25CDK81.72345350
26TAOK11.58794807
27RIPK41.57937506
28RAF11.56981662
29MELK1.53309249
30IRAK31.51373713
31SIK11.48436545
32DYRK21.47873980
33MUSK1.45196326
34STK31.35748721
35PAK21.30768571
36MTOR1.30583096
37CDC42BPA1.29595068
38CDC71.26904387
39MAPKAPK31.25739237
40ICK1.24732504
41OXSR11.23331576
42CDK91.17911062
43CSNK1G11.16093829
44STK391.12387503
45MAPKAPK51.11856599
46DAPK21.08996693
47MAP3K81.08057962
48CAMK11.02979444
49PRKCI1.01540972
50PAK60.97004065
51PRKD30.96069756
52IRAK20.95275791
53CSNK1G30.92393763
54NLK0.90924036
55PINK10.87947541
56CHEK20.87036760
57PLK10.86362000
58RET0.86143161
59KSR10.83573906
60FER0.82583725
61PIM20.80762943
62CSNK1G20.76962274
63CSNK1A1L0.76515593
64NEK20.73826776
65ABL20.73771197
66MAP3K110.72273574
67WNK10.69220969
68BUB10.67881036
69EPHA20.67176031
70MAP3K40.65932495
71GSK3A0.63009185
72PRKAA10.59513376
73EPHB10.58598390
74BCKDK0.58480342
75LRRK20.58297741
76CAMKK10.57215642
77PRKD20.54543733
78PRKAA20.52436175
79AURKA0.49686494
80ACVR1B0.49503176
81HIPK20.49103897
82RPS6KA20.48820222
83YES10.48452480
84STK380.48329776
85MAPK110.48241127
86TTN0.48094312
87AURKB0.47786150
88PDPK10.47721143
89MAPK130.47095711
90SGK4940.46538255
91SGK2230.46538255
92LMTK20.46478030
93EPHA30.41296179
94MAP2K40.41073615
95TYRO30.40671747
96MINK10.39454984
97MAPK150.38693090
98PDK10.38437414
99PTK60.37620372
100SGK10.37340852
101STK110.36858754
102PRKCZ0.36344290
103DAPK30.36012728
104CHUK0.35007933
105WNK30.31921194
106TESK10.31845500
107TRPM70.31747614
108PRKD10.31036173
109MAP2K10.28585143
110MAP2K20.28422873
111TESK20.28051370
112IRAK10.27782499
113MAP3K10.27440655
114SGK20.26679580
115NEK90.26480590
116GSK3B0.26171958
117JAK20.25818692
118DMPK0.25802022
119IRAK40.25797749
120TRIB30.25719223
121CDK40.24995329
122ILK0.24249946
123MARK20.23969605
124DDR20.23801323
125RIPK10.23584378
126MAPK100.23366531
127NUAK10.23318947
128MAPK80.23107811
129MAP4K10.22559949
130BRD40.22133773
131KIT0.21247158
132AKT10.20931224
133ABL10.20835533
134SCYL20.20156124
135ERN10.20096948
136MAP2K70.19923721
137MAP2K60.19335383
138RPS6KB20.18415072
139MAPK10.18366391
140ERBB20.18229805
141MAP3K30.18071547
142CDK70.17963762
143MAP3K50.17366317
144CAMK40.17206940
145CSNK1D0.16288043
146PDGFRB0.15377272
147PAK10.14503303
148ROCK20.14323999
149PTK20.14301073
150MAPK140.13548354
151FRK0.13021695
152MET0.12888041
153SGK30.12563626
154PKN20.12539853
155TGFBR20.12024700
156CAMK2A0.11582025
157NTRK10.11138314
158CAMKK20.10948828
159RPS6KA30.10523421
160EIF2AK10.10204263
161WNK40.10027404
162ATM0.09109156
163FGFR40.08644405
164CDK10.06747666
165MAP3K70.06712220

Predicted pathways (KEGG)

RankGene SetZ-score
1Fatty acid biosynthesis_Homo sapiens_hsa000617.40647477
2Ovarian steroidogenesis_Homo sapiens_hsa049133.80187119
3Renin-angiotensin system_Homo sapiens_hsa046143.57137426
4Vitamin B6 metabolism_Homo sapiens_hsa007503.47248688
5Primary bile acid biosynthesis_Homo sapiens_hsa001203.03164473
6Ascorbate and aldarate metabolism_Homo sapiens_hsa000532.98327619
7Prostate cancer_Homo sapiens_hsa052152.76062598
8Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010402.61355662
9Glycine, serine and threonine metabolism_Homo sapiens_hsa002602.32135793
10Cysteine and methionine metabolism_Homo sapiens_hsa002702.31915430
11Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.26293421
12Arginine biosynthesis_Homo sapiens_hsa002202.20681754
13Folate biosynthesis_Homo sapiens_hsa007902.17278104
14alpha-Linolenic acid metabolism_Homo sapiens_hsa005922.13404948
15Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049612.07968932
16Complement and coagulation cascades_Homo sapiens_hsa046102.06379657
17Linoleic acid metabolism_Homo sapiens_hsa005912.00861225
18RNA degradation_Homo sapiens_hsa030181.95874343
19Circadian rhythm_Homo sapiens_hsa047101.94785581
20Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.91717756
21Cell cycle_Homo sapiens_hsa041101.88787795
22Ether lipid metabolism_Homo sapiens_hsa005651.78834433
23Nitrogen metabolism_Homo sapiens_hsa009101.78382027
24Basal transcription factors_Homo sapiens_hsa030221.77714198
25Vascular smooth muscle contraction_Homo sapiens_hsa042701.75992320
26Histidine metabolism_Homo sapiens_hsa003401.73927680
27Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.68922087
28Tryptophan metabolism_Homo sapiens_hsa003801.65323655
29Propanoate metabolism_Homo sapiens_hsa006401.65207635
30Peroxisome_Homo sapiens_hsa041461.64636667
31Fatty acid degradation_Homo sapiens_hsa000711.61755420
32Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.59462210
33AMPK signaling pathway_Homo sapiens_hsa041521.59014968
34Butanoate metabolism_Homo sapiens_hsa006501.55211950
35Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.49179776
36Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.48093564
37Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.46445736
38Longevity regulating pathway - mammal_Homo sapiens_hsa042111.46389508
39Steroid biosynthesis_Homo sapiens_hsa001001.42224329
40beta-Alanine metabolism_Homo sapiens_hsa004101.39801701
41Fructose and mannose metabolism_Homo sapiens_hsa000511.38540062
42Oocyte meiosis_Homo sapiens_hsa041141.36852680
43Aldosterone synthesis and secretion_Homo sapiens_hsa049251.36388058
44Sulfur metabolism_Homo sapiens_hsa009201.34368926
45Steroid hormone biosynthesis_Homo sapiens_hsa001401.27824067
46Insulin resistance_Homo sapiens_hsa049311.27324420
47Pancreatic cancer_Homo sapiens_hsa052121.26766249
48Adipocytokine signaling pathway_Homo sapiens_hsa049201.25562728
49Thyroid hormone synthesis_Homo sapiens_hsa049181.25557528
50Pyruvate metabolism_Homo sapiens_hsa006201.24367191
51Glucagon signaling pathway_Homo sapiens_hsa049221.22391501
52Retinol metabolism_Homo sapiens_hsa008301.20707776
53Arginine and proline metabolism_Homo sapiens_hsa003301.19972695
54Progesterone-mediated oocyte maturation_Homo sapiens_hsa049141.18863822
55Mineral absorption_Homo sapiens_hsa049781.18700564
56Fatty acid metabolism_Homo sapiens_hsa012121.18516807
57mTOR signaling pathway_Homo sapiens_hsa041501.17206832
58Acute myeloid leukemia_Homo sapiens_hsa052211.16504797
59Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.14589611
60Phenylalanine metabolism_Homo sapiens_hsa003601.13453199
61Chemical carcinogenesis_Homo sapiens_hsa052041.13384152
62Longevity regulating pathway - multiple species_Homo sapiens_hsa042131.13287697
63Regulation of lipolysis in adipocytes_Homo sapiens_hsa049231.13240198
64Insulin signaling pathway_Homo sapiens_hsa049101.12862879
65Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.10897361
66PPAR signaling pathway_Homo sapiens_hsa033201.07140158
67Estrogen signaling pathway_Homo sapiens_hsa049151.04812462
68Fatty acid elongation_Homo sapiens_hsa000621.03765256
69Renin secretion_Homo sapiens_hsa049241.02867404
70Caffeine metabolism_Homo sapiens_hsa002321.01180948
71Pentose and glucuronate interconversions_Homo sapiens_hsa000401.00451259
72Bile secretion_Homo sapiens_hsa049760.99743809
73Glycerophospholipid metabolism_Homo sapiens_hsa005640.98498550
74Dorso-ventral axis formation_Homo sapiens_hsa043200.98071001
75Selenocompound metabolism_Homo sapiens_hsa004500.96398552
76TGF-beta signaling pathway_Homo sapiens_hsa043500.93598632
77Adherens junction_Homo sapiens_hsa045200.93254178
78Biosynthesis of amino acids_Homo sapiens_hsa012300.91279688
79Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.90974181
80Tight junction_Homo sapiens_hsa045300.89825883
81Long-term depression_Homo sapiens_hsa047300.87223472
82Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.86039033
83Insulin secretion_Homo sapiens_hsa049110.85461915
84Type II diabetes mellitus_Homo sapiens_hsa049300.85303621
85Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.84948581
86Salivary secretion_Homo sapiens_hsa049700.84552436
87* Transcriptional misregulation in cancer_Homo sapiens_hsa052020.83999112
88cGMP-PKG signaling pathway_Homo sapiens_hsa040220.82809057
89Pancreatic secretion_Homo sapiens_hsa049720.82584428
90Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.82006225
91Cholinergic synapse_Homo sapiens_hsa047250.80875940
92Serotonergic synapse_Homo sapiens_hsa047260.80295457
93Drug metabolism - other enzymes_Homo sapiens_hsa009830.74030339
94Other glycan degradation_Homo sapiens_hsa005110.73818261
95Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.69388776
96Glutathione metabolism_Homo sapiens_hsa004800.69259431
97Base excision repair_Homo sapiens_hsa034100.68972629
98Platelet activation_Homo sapiens_hsa046110.68870553
99Thyroid hormone signaling pathway_Homo sapiens_hsa049190.68358479
100Endometrial cancer_Homo sapiens_hsa052130.67711832
101Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.64864042
102Lysine degradation_Homo sapiens_hsa003100.64492492
103cAMP signaling pathway_Homo sapiens_hsa040240.63656677
104Chronic myeloid leukemia_Homo sapiens_hsa052200.62463901
105Long-term potentiation_Homo sapiens_hsa047200.62233548
106Fanconi anemia pathway_Homo sapiens_hsa034600.61962220
107Non-homologous end-joining_Homo sapiens_hsa034500.60876331
108Regulation of autophagy_Homo sapiens_hsa041400.60190202
109Phosphatidylinositol signaling system_Homo sapiens_hsa040700.59058169
110Choline metabolism in cancer_Homo sapiens_hsa052310.57528883
111ErbB signaling pathway_Homo sapiens_hsa040120.57322686
112Oxytocin signaling pathway_Homo sapiens_hsa049210.55010198
113Staphylococcus aureus infection_Homo sapiens_hsa051500.54563276
114Prolactin signaling pathway_Homo sapiens_hsa049170.52846032
115Cocaine addiction_Homo sapiens_hsa050300.51482434
116GnRH signaling pathway_Homo sapiens_hsa049120.51455106
117Homologous recombination_Homo sapiens_hsa034400.50693153
118Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.50615096
119Tyrosine metabolism_Homo sapiens_hsa003500.50313224
120Vitamin digestion and absorption_Homo sapiens_hsa049770.49811907
121Sulfur relay system_Homo sapiens_hsa041220.48276325
122Gap junction_Homo sapiens_hsa045400.48169394
123Non-small cell lung cancer_Homo sapiens_hsa052230.48127083
124Glycerolipid metabolism_Homo sapiens_hsa005610.47984895
125Glycosaminoglycan degradation_Homo sapiens_hsa005310.47434790
126Bladder cancer_Homo sapiens_hsa052190.46867994
127Focal adhesion_Homo sapiens_hsa045100.45980737
128ABC transporters_Homo sapiens_hsa020100.45926068
129Inositol phosphate metabolism_Homo sapiens_hsa005620.45065991
130Glioma_Homo sapiens_hsa052140.44816874
131Hepatitis C_Homo sapiens_hsa051600.43819944
132Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.43181390
133Proteoglycans in cancer_Homo sapiens_hsa052050.41327490
134Phospholipase D signaling pathway_Homo sapiens_hsa040720.41278609
135Arachidonic acid metabolism_Homo sapiens_hsa005900.40948765
136Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.40808418
1372-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.40195001
138RNA polymerase_Homo sapiens_hsa030200.40091256
139p53 signaling pathway_Homo sapiens_hsa041150.39818683
140Amphetamine addiction_Homo sapiens_hsa050310.39399533
141Dilated cardiomyopathy_Homo sapiens_hsa054140.39384221
142Influenza A_Homo sapiens_hsa051640.39245905
143Dopaminergic synapse_Homo sapiens_hsa047280.39015369
144Metabolic pathways_Homo sapiens_hsa011000.38388331
145Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.38143671
146Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.36924559
147Melanogenesis_Homo sapiens_hsa049160.36180182
148Gastric acid secretion_Homo sapiens_hsa049710.35197496
149Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.35116714
150One carbon pool by folate_Homo sapiens_hsa006700.34930111
151Hippo signaling pathway_Homo sapiens_hsa043900.30607240
152Cyanoamino acid metabolism_Homo sapiens_hsa004600.30054159
153Maturity onset diabetes of the young_Homo sapiens_hsa049500.28194922
154FoxO signaling pathway_Homo sapiens_hsa040680.27022393
155Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.26501299
156Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.26429119
157Starch and sucrose metabolism_Homo sapiens_hsa005000.26366534
158Renal cell carcinoma_Homo sapiens_hsa052110.26137709
159* MicroRNAs in cancer_Homo sapiens_hsa052060.25831401
160Notch signaling pathway_Homo sapiens_hsa043300.24921129
161Thyroid cancer_Homo sapiens_hsa052160.24829559
162VEGF signaling pathway_Homo sapiens_hsa043700.24755903
163Nucleotide excision repair_Homo sapiens_hsa034200.24013396
164Fat digestion and absorption_Homo sapiens_hsa049750.23832411
165Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.23407428

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