SLC47A1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene is located within the Smith-Magenis syndrome region on chromosome 17. It encodes a protein of unknown function. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)7.18258259
2L-phenylalanine catabolic process (GO:0006559)7.18258259
3erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)6.99084046
4L-phenylalanine metabolic process (GO:0006558)6.99084046
5aromatic amino acid family catabolic process (GO:0009074)6.61883554
6glyoxylate metabolic process (GO:0046487)6.60520820
7androgen biosynthetic process (GO:0006702)6.51363330
8glucocorticoid biosynthetic process (GO:0006704)6.44529291
9lysine metabolic process (GO:0006553)6.40793422
10lysine catabolic process (GO:0006554)6.40793422
11indole-containing compound catabolic process (GO:0042436)6.12648558
12indolalkylamine catabolic process (GO:0046218)6.12648558
13tryptophan catabolic process (GO:0006569)6.12648558
14cysteine metabolic process (GO:0006534)6.05272516
15urate metabolic process (GO:0046415)5.93978938
16tryptophan metabolic process (GO:0006568)5.77982474
17kynurenine metabolic process (GO:0070189)5.76211455
18* drug transmembrane transport (GO:0006855)5.42417074
19fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)5.38286000
20serine family amino acid catabolic process (GO:0009071)5.34872621
21drug catabolic process (GO:0042737)5.30259540
22bile acid biosynthetic process (GO:0006699)5.25063632
23homocysteine metabolic process (GO:0050667)5.21460056
24amino-acid betaine metabolic process (GO:0006577)5.06899724
25sulfur amino acid catabolic process (GO:0000098)5.05436206
26alpha-linolenic acid metabolic process (GO:0036109)4.88832206
27glucocorticoid metabolic process (GO:0008211)4.88377193
28triglyceride-rich lipoprotein particle remodeling (GO:0034370)4.85352080
29aromatic amino acid family metabolic process (GO:0009072)4.83079445
30cellular ketone body metabolic process (GO:0046950)4.83060942
31exogenous drug catabolic process (GO:0042738)4.78660091
32cellular response to follicle-stimulating hormone stimulus (GO:0071372)4.76791781
33short-chain fatty acid metabolic process (GO:0046459)4.76534403
34alpha-amino acid catabolic process (GO:1901606)4.71180579
35estrogen biosynthetic process (GO:0006703)4.70002186
36regulation of gonadotropin secretion (GO:0032276)4.69548775
37urea cycle (GO:0000050)4.67936036
38urea metabolic process (GO:0019627)4.67936036
39aspartate family amino acid catabolic process (GO:0009068)4.63258307
40epoxygenase P450 pathway (GO:0019373)4.61401696
41serine family amino acid metabolic process (GO:0009069)4.56909101
42* drug transport (GO:0015893)4.56318269
43cellular modified amino acid catabolic process (GO:0042219)4.55699824
44glutamate metabolic process (GO:0006536)4.47245010
45cellular amino acid catabolic process (GO:0009063)4.46769984
46cholesterol efflux (GO:0033344)4.42552458
47bile acid metabolic process (GO:0008206)4.41221139
482-oxoglutarate metabolic process (GO:0006103)4.38975938
49nitrogen cycle metabolic process (GO:0071941)4.35466177
50androgen metabolic process (GO:0008209)4.33826573
51indolalkylamine metabolic process (GO:0006586)4.31839936
52cellular glucuronidation (GO:0052695)4.31343812
53plasma lipoprotein particle clearance (GO:0034381)4.30348269
54benzene-containing compound metabolic process (GO:0042537)4.27936343
55tyrosine metabolic process (GO:0006570)4.25639785
56acetyl-CoA metabolic process (GO:0006084)4.25426880
57omega-hydroxylase P450 pathway (GO:0097267)4.22101777
58peptidyl-glutamic acid carboxylation (GO:0017187)4.21733636
59protein carboxylation (GO:0018214)4.21733636
60fatty acid beta-oxidation (GO:0006635)4.19849294
61negative regulation of fibrinolysis (GO:0051918)4.17979257
62ketone body metabolic process (GO:1902224)4.17069488
63response to mercury ion (GO:0046689)4.16827329
64cellular biogenic amine catabolic process (GO:0042402)4.16379369
65amine catabolic process (GO:0009310)4.16379369
66high-density lipoprotein particle remodeling (GO:0034375)4.14080687
67serine family amino acid biosynthetic process (GO:0009070)4.14051170
68carnitine metabolic process (GO:0009437)4.08172031
69cellular response to gonadotropin stimulus (GO:0071371)4.06406192
70fatty acid oxidation (GO:0019395)4.06125224
71glycine metabolic process (GO:0006544)4.02827835
72organic acid catabolic process (GO:0016054)4.02548973
73carboxylic acid catabolic process (GO:0046395)4.02548973
74uronic acid metabolic process (GO:0006063)4.02408818
75glucuronate metabolic process (GO:0019585)4.02408818
76dicarboxylic acid biosynthetic process (GO:0043650)4.00605942
77valine metabolic process (GO:0006573)3.99072835
78ethanol oxidation (GO:0006069)3.98938223
79lipid oxidation (GO:0034440)3.98263220
80regulation of fibrinolysis (GO:0051917)3.98046317
81coenzyme catabolic process (GO:0009109)3.95776995
82negative regulation of sterol transport (GO:0032372)3.95169945
83negative regulation of cholesterol transport (GO:0032375)3.95169945
84phosphate ion transport (GO:0006817)3.94416423
85complement activation, alternative pathway (GO:0006957)3.91994425
86regulation of protein activation cascade (GO:2000257)3.90148181
87blood coagulation, intrinsic pathway (GO:0007597)3.89251862
88oxidative demethylation (GO:0070989)3.89161502
89monocarboxylic acid catabolic process (GO:0072329)3.88948540
90intestinal cholesterol absorption (GO:0030299)3.87143377
91regulation of triglyceride catabolic process (GO:0010896)3.87095959
92aldehyde catabolic process (GO:0046185)3.86085533
93fatty acid catabolic process (GO:0009062)3.83974033
94branched-chain amino acid metabolic process (GO:0009081)3.83811566
95positive regulation of triglyceride biosynthetic process (GO:0010867)3.82805008
96response to follicle-stimulating hormone (GO:0032354)3.80457821
97triglyceride homeostasis (GO:0070328)3.77431913
98acylglycerol homeostasis (GO:0055090)3.77431913
99phosphate ion transmembrane transport (GO:0035435)3.76030742
100positive regulation of triglyceride metabolic process (GO:0090208)3.75550130
101drug metabolic process (GO:0017144)3.74402089
102quaternary ammonium group transport (GO:0015697)3.73610376
103flavonoid metabolic process (GO:0009812)3.72177228
104branched-chain amino acid catabolic process (GO:0009083)3.71424665
105regulation of cholesterol homeostasis (GO:2000188)3.70239397
106tricarboxylic acid metabolic process (GO:0072350)3.69840196
107regulation of cholesterol esterification (GO:0010872)3.69015341
108regulation of complement activation (GO:0030449)3.63580402
109regulation of plasminogen activation (GO:0010755)3.63421638
110regulation of bile acid biosynthetic process (GO:0070857)3.62821540
111bile acid and bile salt transport (GO:0015721)3.60469611
112reverse cholesterol transport (GO:0043691)3.58552796
113regulation of triglyceride biosynthetic process (GO:0010866)3.58509544
114hormone biosynthetic process (GO:0042446)3.58477721
115plasma lipoprotein particle remodeling (GO:0034369)3.56822406
116protein-lipid complex remodeling (GO:0034368)3.56822406
117macromolecular complex remodeling (GO:0034367)3.56822406
118sodium-independent organic anion transport (GO:0043252)3.56440013
119low-density lipoprotein particle clearance (GO:0034383)3.53556440
120arginine metabolic process (GO:0006525)3.52779540
121S-adenosylmethionine metabolic process (GO:0046500)3.48586392
122small molecule catabolic process (GO:0044282)3.41934428
123plasma lipoprotein particle organization (GO:0071827)3.40029585
124response to nitrosative stress (GO:0051409)3.39870476
125regulation of triglyceride metabolic process (GO:0090207)3.38956460
126imidazole-containing compound metabolic process (GO:0052803)3.38829531
127fibrinolysis (GO:0042730)3.37944412
128positive regulation of male gonad development (GO:2000020)3.37541212
129cholesterol catabolic process (GO:0006707)3.30477686
130sterol catabolic process (GO:0016127)3.30477686
131cholesterol transport (GO:0030301)3.21403606
132sterol transport (GO:0015918)3.21403606
133steroid catabolic process (GO:0006706)3.21102614
134negative regulation of protein activation cascade (GO:2000258)3.21001345
135amyloid precursor protein catabolic process (GO:0042987)3.17740469
136protein-lipid complex subunit organization (GO:0071825)3.16020306
137heme transport (GO:0015886)3.06446803
138phospholipid efflux (GO:0033700)3.06417607
139positive regulation of lipid storage (GO:0010884)3.06096488
140estrogen metabolic process (GO:0008210)3.03427913
141low-density lipoprotein particle remodeling (GO:0034374)2.99496545
142protein activation cascade (GO:0072376)2.98965389
143negative regulation of lipase activity (GO:0060192)2.97400966
144very-low-density lipoprotein particle assembly (GO:0034379)2.96334140
145response to leptin (GO:0044321)2.91814187
146steroid biosynthetic process (GO:0006694)2.90809096
147negative regulation of hemostasis (GO:1900047)2.89714088
148negative regulation of blood coagulation (GO:0030195)2.89714088
149cholesterol homeostasis (GO:0042632)2.89316409

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1RXR_22158963_ChIP-Seq_LIVER_Mouse7.95505995
2* PPARA_22158963_ChIP-Seq_LIVER_Mouse6.81668814
3* LXR_22158963_ChIP-Seq_LIVER_Mouse6.14783217
4* EGR1_23403033_ChIP-Seq_LIVER_Mouse5.84358689
5PPARG_19300518_ChIP-PET_3T3-L1_Mouse5.28760179
6FOXO1_23066095_ChIP-Seq_LIVER_Mouse4.71411863
7CEBPA_23403033_ChIP-Seq_LIVER_Mouse4.15561405
8NR1I2_20693526_ChIP-Seq_LIVER_Mouse3.87039091
9CEBPB_23403033_ChIP-Seq_LIVER_Mouse3.43630450
10GBX2_23144817_ChIP-Seq_PC3_Human2.84091141
11VDR_22108803_ChIP-Seq_LS180_Human2.63021090
12TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse2.48019499
13ZNF274_21170338_ChIP-Seq_K562_Hela2.44674842
14IGF1R_20145208_ChIP-Seq_DFB_Human2.38031094
15HNF4A_19761587_ChIP-ChIP_CACO-2_Human2.30031408
16TCF7L2_21901280_ChIP-Seq_H4IIE_Rat2.14026001
17ESR1_17901129_ChIP-ChIP_LIVER_Mouse11.0340629
18GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.90520425
19PCGF2_27294783_Chip-Seq_NPCs_Mouse1.90169969
20CLOCK_20551151_ChIP-Seq_293T_Human1.86313663
21ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.85260680
22ZFP57_27257070_Chip-Seq_ESCs_Mouse1.79309826
23FLI1_27457419_Chip-Seq_LIVER_Mouse1.78848054
24PCGF2_27294783_Chip-Seq_ESCs_Mouse1.77776831
25* FOXA2_19822575_ChIP-Seq_HepG2_Human1.64864504
26ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.55823702
27CTBP2_25329375_ChIP-Seq_LNCAP_Human1.53414279
28* HNF4A_19822575_ChIP-Seq_HepG2_Human1.51457307
29ER_23166858_ChIP-Seq_MCF-7_Human1.48771520
30RARG_19884340_ChIP-ChIP_MEFs_Mouse1.48396134
31EZH2_27294783_Chip-Seq_NPCs_Mouse1.43634456
32SUZ12_27294783_Chip-Seq_NPCs_Mouse1.43347279
33TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.41681326
34NFE2_27457419_Chip-Seq_LIVER_Mouse1.36421439
35FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.34986411
36STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.34761027
37ESR1_21235772_ChIP-Seq_MCF-7_Human1.32903849
38POU3F2_20337985_ChIP-ChIP_501MEL_Human1.30910451
39AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.29559247
40SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.29031285
41SOX2_19829295_ChIP-Seq_ESCs_Human1.28291997
42NANOG_19829295_ChIP-Seq_ESCs_Human1.28291997
43CTBP1_25329375_ChIP-Seq_LNCAP_Human1.28069834
44PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.27781413
45TAF15_26573619_Chip-Seq_HEK293_Human1.25830799
46* SMAD4_21741376_ChIP-Seq_EPCs_Human1.25012565
47UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.24298899
48AR_21572438_ChIP-Seq_LNCaP_Human1.23849365
49EZH2_22144423_ChIP-Seq_EOC_Human1.23583589
50CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.23295035
51P300_19829295_ChIP-Seq_ESCs_Human1.23135135
52ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.23037231
53AR_25329375_ChIP-Seq_VCAP_Human1.20387331
54STAT3_23295773_ChIP-Seq_U87_Human1.19429578
55ESR2_21235772_ChIP-Seq_MCF-7_Human1.18193640
56SOX2_27498859_Chip-Seq_STOMACH_Mouse1.17014138
57* CRX_20693478_ChIP-Seq_RETINA_Mouse1.16898526
58TCF4_22108803_ChIP-Seq_LS180_Human1.15234619
59THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.15088381
60NR3C1_21868756_ChIP-Seq_MCF10A_Human1.14969396
61E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.14889332
62BP1_19119308_ChIP-ChIP_Hs578T_Human1.13843449
63SMAD4_21799915_ChIP-Seq_A2780_Human1.12493616
64KLF5_20875108_ChIP-Seq_MESCs_Mouse1.12117160
65TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.10720152
66CDX2_19796622_ChIP-Seq_MESCs_Mouse1.09535900
67CBX2_27304074_Chip-Seq_ESCs_Mouse1.09180690
68PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.08863974
69SMAD3_21741376_ChIP-Seq_EPCs_Human1.07999980
70* TCF4_23295773_ChIP-Seq_U87_Human1.06309485
71HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.06270976
72GATA4_25053715_ChIP-Seq_YYC3_Human1.05705334
73GATA1_22025678_ChIP-Seq_K562_Human1.04477105
74CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.04081243
75SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse1.03562889
76IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.03457171
77NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.03284805
78* SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.02770031
79RXRA_24833708_ChIP-Seq_LIVER_Mouse1.02270738
80* OCT4_21477851_ChIP-Seq_ESCs_Mouse1.02021219
81* RUNX2_22187159_ChIP-Seq_PCA_Human1.01625733
82CBP_20019798_ChIP-Seq_JUKART_Human1.01334893
83IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.01334893
84PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.00930726
85ETV2_25802403_ChIP-Seq_MESCs_Mouse0.99896713
86HTT_18923047_ChIP-ChIP_STHdh_Human0.98886928
87NCOR_22424771_ChIP-Seq_293T_Human0.98621350
88MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse0.96843133
89TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.96582658
90POU5F1_26923725_Chip-Seq_MESODERM_Mouse0.96582658
91EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse0.95480736
92CDX2_20551321_ChIP-Seq_CACO-2_Human0.91517449
93BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.91464017
94GATA3_21878914_ChIP-Seq_MCF-7_Human0.91173186
95TP53_22573176_ChIP-Seq_HFKS_Human0.89892680
96FOXH1_21741376_ChIP-Seq_EPCs_Human0.89570041
97RAC3_21632823_ChIP-Seq_H3396_Human0.89294670
98OCT4_20526341_ChIP-Seq_ESCs_Human0.88864208
99SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.87837791
100* FOXH1_21741376_ChIP-Seq_ESCs_Human0.86594191
101RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.86534472
102SMAD3_21741376_ChIP-Seq_HESCs_Human0.86258478
103FLI1_21867929_ChIP-Seq_TH2_Mouse0.85303909
104STAT3_18555785_Chip-Seq_ESCs_Mouse0.85182478
105AUTS2_25519132_ChIP-Seq_293T-REX_Human0.82914695
106AR_21915096_ChIP-Seq_LNCaP-1F5_Human0.80734918
107STAT3_1855785_ChIP-Seq_MESCs_Mouse0.80331802
108ZNF263_19887448_ChIP-Seq_K562_Human0.79712769
109RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human0.79115036
110SALL4_18804426_ChIP-ChIP_XEN_Mouse0.78499842
111LXR_22292898_ChIP-Seq_THP-1_Human0.77415295
112EGR1_19032775_ChIP-ChIP_M12_Human0.75074128
113NRF2_20460467_ChIP-Seq_MEFs_Mouse0.73638919
114NFE2L2_20460467_ChIP-Seq_MEFs_Mouse0.73638919
115ZNF652_21678463_ChIP-ChIP_ZR75-1_Human0.73335013
116BMI1_19503595_ChIP-Seq_MEFsC_Mouse0.71031493
117CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.70187592
118* TBX20_22328084_ChIP-Seq_HEART_Mouse0.69993520
119* TBX20_22080862_ChIP-Seq_HEART_Mouse0.69993520
120Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse0.69784911
121SREBP1_19666523_ChIP-Seq_LIVER_Mouse0.69629535
122PPAR_26484153_Chip-Seq_NCI-H1993_Human0.68965944
123ESR1_15608294_ChIP-ChIP_MCF-7_Human0.68341439
124CHD7_19251738_ChIP-ChIP_MESCs_Mouse0.67072035
125FOXO3_23340844_ChIP-Seq_DLD1_Human0.66767283
126* RAD21_21589869_ChIP-Seq_MESCs_Mouse0.66284556
127GATA6_25053715_ChIP-Seq_YYC3_Human0.66052123
128KAP1_22055183_ChIP-Seq_ESCs_Mouse0.64940030
129ESR1_20079471_ChIP-ChIP_T-47D_Human0.63893903
130TRIM28_21343339_ChIP-Seq_HEK293_Human0.63754197
131IRF8_22096565_ChIP-ChIP_GC-B_Human0.63627175
132CEBPB_22108803_ChIP-Seq_LS180_Human0.62902915
133SREBP2_21459322_ChIP-Seq_LIVER_Mouse0.62310976
134NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human0.61696819
135FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human0.59150521
136MYC_19915707_ChIP-ChIP_AK7_Human0.56502377
137* RARA_24833708_ChIP-Seq_LIVER_Mouse0.55382703
138PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.55328028
139RACK7_27058665_Chip-Seq_MCF-7_Human0.55080325
140CBP_21632823_ChIP-Seq_H3396_Human0.54925968
141AR_20517297_ChIP-Seq_VCAP_Human0.54733379
142* ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.54695145
143ESR1_22446102_ChIP-Seq_UTERUS_Mouse0.53612209
144CDX2_22108803_ChIP-Seq_LS180_Human0.52953049
145GATA2_19941826_ChIP-Seq_K562_Human0.51746505
146* ESET_19884257_ChIP-Seq_ESCs_Mouse0.51338494
147TAF2_19829295_ChIP-Seq_ESCs_Human0.50970009
148FOXA1_25552417_ChIP-Seq_VCAP_Human0.50705146
149SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.50292313
150SOX2_20726797_ChIP-Seq_SW620_Human0.49838128
151STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse0.49820591
152EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human0.49479017
153GLI1_17442700_ChIP-ChIP_MESCs_Mouse0.49358416
154GATA1_19941826_ChIP-Seq_K562_Human0.49340877
155PPARD_23208498_ChIP-Seq_MDA-MB-231_Human0.48864758
156TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.48641908
157FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human0.48475616
158* STAT1_17558387_ChIP-Seq_HELA_Human0.47653322
159PPARG_20887899_ChIP-Seq_3T3-L1_Mouse0.47391911
160EP300_21415370_ChIP-Seq_HL-1_Mouse0.47051639
161SMAD2/3_21741376_ChIP-Seq_ESCs_Human0.47048924
162AR_21909140_ChIP-Seq_LNCAP_Human0.46934658
163ERG_21242973_ChIP-ChIP_JURKAT_Human0.46362831
164GATA1_19941827_ChIP-Seq_MEL_Mouse0.46339960
165PBX1_22567123_ChIP-ChIP_OVCAR3_Human0.46036406
166FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.45418014
167P63_20808887_ChIP-Seq_KERATINOCYTES_Human0.45376020
168BCAT_22108803_ChIP-Seq_LS180_Human0.44987946
169PIAS1_25552417_ChIP-Seq_VCAP_Human0.44447440

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005360_urolithiasis8.24965188
2MP0002139_abnormal_hepatobiliary_system7.72066088
3MP0005085_abnormal_gallbladder_physiolo5.58892077
4MP0005365_abnormal_bile_salt5.41682851
5* MP0008875_abnormal_xenobiotic_pharmacok4.54522817
6MP0003252_abnormal_bile_duct3.78665883
7MP0003806_abnormal_nucleotide_metabolis3.74469680
8MP0003283_abnormal_digestive_organ3.70064288
9* MP0005332_abnormal_amino_acid3.63047742
10MP0003195_calcinosis3.59182713
11MP0004019_abnormal_vitamin_homeostasis3.24806153
12MP0010329_abnormal_lipoprotein_level2.91805684
13MP0008004_abnormal_stomach_pH2.83477687
14MP0002138_abnormal_hepatobiliary_system2.74625877
15MP0009840_abnormal_foam_cell2.44581347
16MP0005083_abnormal_biliary_tract2.40659752
17MP0004043_abnormal_pH_regulation2.36335644
18MP0001666_abnormal_nutrient_absorption2.29299684
19MP0009643_abnormal_urine_homeostasis2.24564471
20MP0003191_abnormal_cellular_cholesterol1.96469405
21MP0004145_abnormal_muscle_electrophysio1.90130879
22MP0002118_abnormal_lipid_homeostasis1.89076848
23MP0005319_abnormal_enzyme/_coenzyme1.88231324
24MP0008995_early_reproductive_senescence1.83998125
25MP0000609_abnormal_liver_physiology1.81732751
26MP0000639_abnormal_adrenal_gland1.74421647
27MP0005584_abnormal_enzyme/coenzyme_acti1.71765267
28MP0005636_abnormal_mineral_homeostasis1.70967792
29MP0004233_abnormal_muscle_weight1.61933726
30MP0005451_abnormal_body_composition1.59774672
31MP0001764_abnormal_homeostasis1.55864384
32MP0003186_abnormal_redox_activity1.55144748
33MP0001756_abnormal_urination1.47860562
34MP0002909_abnormal_adrenal_gland1.37087185
35MP0001765_abnormal_ion_homeostasis1.36716396
36MP0005551_abnormal_eye_electrophysiolog1.36463353
37MP0002136_abnormal_kidney_physiology1.30532764
38MP0003868_abnormal_feces_composition1.25609629
39MP0006036_abnormal_mitochondrial_physio1.21781910
40MP0005084_abnormal_gallbladder_morpholo1.06977414
41MP0005670_abnormal_white_adipose1.04751014
42MP0003879_abnormal_hair_cell1.03440834
43MP0000598_abnormal_liver_morphology1.03259583
44MP0002160_abnormal_reproductive_system0.99909962
45MP0002837_dystrophic_cardiac_calcinosis0.98993732
46MP0001501_abnormal_sleep_pattern0.98713530
47MP0009764_decreased_sensitivity_to0.98239276
48MP0005646_abnormal_pituitary_gland0.96823810
49MP0005410_abnormal_fertilization0.96807555
50MP0008775_abnormal_heart_ventricle0.96061932
51MP0003705_abnormal_hypodermis_morpholog0.93161426
52MP0002332_abnormal_exercise_endurance0.93131436
53MP0002876_abnormal_thyroid_physiology0.92431995
54MP0003122_maternal_imprinting0.92159660
55MP0005389_reproductive_system_phenotype0.89149513
56* MP0009642_abnormal_blood_homeostasis0.88423139
57MP0005187_abnormal_penis_morphology0.86280092
58MP0003315_abnormal_perineum_morphology0.85521499
59MP0009697_abnormal_copulation0.85275782
60MP0005535_abnormal_body_temperature0.84789963
61MP0001324_abnormal_eye_pigmentation0.83469847
62MP0003656_abnormal_erythrocyte_physiolo0.81599766
63MP0005647_abnormal_sex_gland0.81182737
64MP0008469_abnormal_protein_level0.78941198
65MP0002078_abnormal_glucose_homeostasis0.78374092
66MP0004130_abnormal_muscle_cell0.78262621
67MP0003011_delayed_dark_adaptation0.75969200
68MP0009763_increased_sensitivity_to0.75803433
69MP0000604_amyloidosis0.75568725
70MP0005058_abnormal_lysosome_morphology0.74945699
71MP0002928_abnormal_bile_duct0.73752310
72MP0010368_abnormal_lymphatic_system0.71456148
73MP0005666_abnormal_adipose_tissue0.71376975
74MP0005220_abnormal_exocrine_pancreas0.71375530
75MP0001919_abnormal_reproductive_system0.71304088
76MP0001661_extended_life_span0.71023616
77MP0000230_abnormal_systemic_arterial0.70554134
78MP0006035_abnormal_mitochondrial_morpho0.70442270
79MP0003632_abnormal_nervous_system0.70268007
80MP0005376_homeostasis/metabolism_phenot0.69430758
81MP0005408_hypopigmentation0.69154028
82MP0004215_abnormal_myocardial_fiber0.68756638
83MP0002254_reproductive_system_inflammat0.68355116
84MP0000013_abnormal_adipose_tissue0.67865911
85MP0003718_maternal_effect0.66153323
86MP0000538_abnormal_urinary_bladder0.65933880
87MP0002971_abnormal_brown_adipose0.65666480
88MP0002736_abnormal_nociception_after0.65505292
89MP0002168_other_aberrant_phenotype0.65390329
90MP0008961_abnormal_basal_metabolism0.65236530
91MP0001968_abnormal_touch/_nociception0.64583143
92MP0005266_abnormal_metabolism0.64473171
93MP0003878_abnormal_ear_physiology0.63542533
94MP0005377_hearing/vestibular/ear_phenot0.63542533
95MP0003646_muscle_fatigue0.63426947
96MP0001485_abnormal_pinna_reflex0.63235021
97MP0004924_abnormal_behavior0.63206552
98MP0005386_behavior/neurological_phenoty0.63206552
99MP0002090_abnormal_vision0.62787194
100MP0010386_abnormal_urinary_bladder0.61114041
101MP0005253_abnormal_eye_physiology0.60403030
102MP0009765_abnormal_xenobiotic_induced0.58721044
103MP0003698_abnormal_male_reproductive0.58665880
104MP0003638_abnormal_response/metabolism_0.58377578
105MP0009745_abnormal_behavioral_response0.56997410
106MP0003699_abnormal_female_reproductive0.56838860
107MP0005395_other_phenotype0.55986592
108MP0001984_abnormal_olfaction0.55409107
109MP0005334_abnormal_fat_pad0.54745573
110MP0002127_abnormal_cardiovascular_syste0.54395609
111MP0005330_cardiomyopathy0.53920498
112MP0000653_abnormal_sex_gland0.53483329
113MP0003329_amyloid_beta_deposits0.52610818
114MP0001119_abnormal_female_reproductive0.52544884
115MP0003690_abnormal_glial_cell0.52342100
116MP0000631_abnormal_neuroendocrine_gland0.51434264
117MP0001958_emphysema0.51360762
118MP0001929_abnormal_gametogenesis0.50129959
119MP0002135_abnormal_kidney_morphology0.49760023
120MP0003300_gastrointestinal_ulcer0.48992501
121MP0004147_increased_porphyrin_level0.47568245
122MP0009053_abnormal_anal_canal0.47234674
123MP0003953_abnormal_hormone_level0.45794964
124MP0002796_impaired_skin_barrier0.41739535
125MP0004264_abnormal_extraembryonic_tissu0.41308997
126MP0002269_muscular_atrophy0.39683493
127MP0009672_abnormal_birth_weight0.38803176
128MP0008874_decreased_physiological_sensi0.36240996
129MP0005166_decreased_susceptibility_to0.34780473
130MP0005448_abnormal_energy_balance0.34307989
131MP0010234_abnormal_vibrissa_follicle0.33396268
132MP0003075_altered_response_to0.31925156
133MP0005165_increased_susceptibility_to0.30830817
134MP0008872_abnormal_physiological_respon0.30598046
135MP0005167_abnormal_blood-brain_barrier0.30490240
136MP0000747_muscle_weakness0.30118860
137MP0003724_increased_susceptibility_to0.29876132
138MP0008873_increased_physiological_sensi0.29074849
139MP0002896_abnormal_bone_mineralization0.28520358
140MP0009384_cardiac_valve_regurgitation0.27276491
141MP0004036_abnormal_muscle_relaxation0.27043268
142MP0004782_abnormal_surfactant_physiolog0.26531346

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of aromatic amino acid family metabolism (HP:0004338)6.04146109
2Intrahepatic cholestasis (HP:0001406)5.53085259
3Hyperglycinuria (HP:0003108)5.18507867
4Abnormality of glutamine family amino acid metabolism (HP:0010902)5.10709013
5Deep venous thrombosis (HP:0002625)5.07947943
6Xanthomatosis (HP:0000991)5.06699652
7Abnormality of monocarboxylic acid metabolism (HP:0010996)5.04351539
8Gout (HP:0001997)5.00058455
9Abnormality of serine family amino acid metabolism (HP:0010894)4.74435282
10Abnormality of glycine metabolism (HP:0010895)4.74435282
11Ketosis (HP:0001946)4.73415639
12Hyperammonemia (HP:0001987)4.52934546
13Hyperglycinemia (HP:0002154)4.44886904
14Hypobetalipoproteinemia (HP:0003563)4.27999920
15Prolonged partial thromboplastin time (HP:0003645)4.22130445
16Abnormality of aspartate family amino acid metabolism (HP:0010899)4.21896192
17Ketoacidosis (HP:0001993)4.18030242
18Proximal tubulopathy (HP:0000114)4.01773362
19Abnormality of purine metabolism (HP:0004352)4.01115500
20Abnormality of fatty-acid metabolism (HP:0004359)3.95733465
21Abnormality of sulfur amino acid metabolism (HP:0004339)3.91004744
22Hyperlipoproteinemia (HP:0010980)3.85638883
23Gonadal dysgenesis (HP:0000133)3.80877907
24Hypoglycemic coma (HP:0001325)3.74787034
25Abnormality of nucleobase metabolism (HP:0010932)3.69468782
26Generalized aminoaciduria (HP:0002909)3.62470617
27Hyperuricemia (HP:0002149)3.59083805
28Increased purine levels (HP:0004368)3.59083805
29Glomerulonephritis (HP:0000099)3.52640821
30Hypokalemic alkalosis (HP:0001949)3.46581871
31Gonadotropin excess (HP:0000837)3.46243315
32Increased circulating renin level (HP:0000848)3.46061559
33Delayed CNS myelination (HP:0002188)3.44698433
34Alkalosis (HP:0001948)3.43556126
35Joint hemorrhage (HP:0005261)3.40586990
36Osteomalacia (HP:0002749)3.39345245
37Complement deficiency (HP:0004431)3.32964019
38Aplasia/Hypoplasia of the tibia (HP:0005772)3.31874743
39Hypolipoproteinemia (HP:0010981)3.29949730
40Epidermoid cyst (HP:0200040)3.27671625
41Short tibia (HP:0005736)3.24409179
42Male pseudohermaphroditism (HP:0000037)3.24328204
43Hyperactive renin-angiotensin system (HP:0000841)3.20787463
44Abnormality of dicarboxylic acid metabolism (HP:0010995)3.20111852
45Dicarboxylic aciduria (HP:0003215)3.20111852
46Metabolic acidosis (HP:0001942)3.17368771
47Abnormality of methionine metabolism (HP:0010901)3.16241550
48Relative macrocephaly (HP:0004482)3.14698471
49Vascular calcification (HP:0004934)3.13050965
50Fat malabsorption (HP:0002630)3.11515667
51Metabolic alkalosis (HP:0200114)3.11303080
52Abnormality of pyrimidine metabolism (HP:0004353)3.06175347
53Abnormality of serum amino acid levels (HP:0003112)3.02773582
54Abnormality of urine glucose concentration (HP:0011016)3.00917917
55Glycosuria (HP:0003076)3.00917917
56Abnormality of the level of lipoprotein cholesterol (HP:0010979)3.00298474
57Abnormal urine output (HP:0012590)2.98465168
58Hypoalphalipoproteinemia (HP:0003233)2.97961330
59Abnormality of the common coagulation pathway (HP:0010990)2.97336712
60Polyuria (HP:0000103)2.93131240
61Abnormality of long-chain fatty-acid metabolism (HP:0010964)2.93126866
62Lethargy (HP:0001254)2.93018661
63Abnormality of carpal bone ossification (HP:0006257)2.84571445
64Hypomagnesemia (HP:0002917)2.81923540
65Hypoplasia of the uterus (HP:0000013)2.81820212
66Conjugated hyperbilirubinemia (HP:0002908)2.80531746
67Cardiovascular calcification (HP:0011915)2.78195495
68Abnormality of proline metabolism (HP:0010907)2.77653878
69Hydroxyprolinuria (HP:0003080)2.77653878
70Cerebral palsy (HP:0100021)2.76525899
71Abnormality of renal excretion (HP:0011036)2.75970767
72Abnormality of chloride homeostasis (HP:0011422)2.75059354
73Hyperbilirubinemia (HP:0002904)2.74952634
74Hepatocellular carcinoma (HP:0001402)2.71409661
75Sex reversal (HP:0012245)2.71061608
76Abnormal sex determination (HP:0012244)2.71061608
77Vomiting (HP:0002013)2.65050416
78Malnutrition (HP:0004395)2.64514159
79Anomalous pulmonary venous return (HP:0010772)2.57925384
80Enlarged kidneys (HP:0000105)2.57083552
81Cerebral edema (HP:0002181)2.55924247
82Spontaneous abortion (HP:0005268)2.54355079
83Rickets (HP:0002748)2.54153019
84Hypercholesterolemia (HP:0003124)2.53318005
85Arthropathy (HP:0003040)2.51785231
86Abnormality of the intrinsic pathway (HP:0010989)2.48968145
87Nephritis (HP:0000123)2.45382068
88Decreased circulating renin level (HP:0003351)2.42614536
89Irritability (HP:0000737)2.38789799
90Cupped ear (HP:0000378)2.36458732
91Facial shape deformation (HP:0011334)2.35762791
92Potter facies (HP:0002009)2.35762791
93Spastic diplegia (HP:0001264)2.34382406
94Neonatal onset (HP:0003623)2.33930585
95Abnormality of magnesium homeostasis (HP:0004921)2.31878463
96Abnormality of complement system (HP:0005339)2.30951866
97Nephrolithiasis (HP:0000787)2.30624974
98Late onset (HP:0003584)2.27632987
99Renal tubular acidosis (HP:0001947)2.26799261
100Azoospermia (HP:0000027)2.26467365
101Hyperphosphaturia (HP:0003109)2.26293397
102Polydipsia (HP:0001959)2.23602078
103Abnormal drinking behavior (HP:0030082)2.23602078
104Fair hair (HP:0002286)2.22946662
105Steatorrhea (HP:0002570)2.22847194
106Sensorimotor neuropathy (HP:0007141)2.21738760
107Abnormal enzyme/coenzyme activity (HP:0012379)2.19974348
108Ovoid vertebral bodies (HP:0003300)2.18491022
109Abnormal hand bone ossification (HP:0010660)2.18347526
110Abnormal biliary tract physiology (HP:0012439)2.17369534
111Bile duct proliferation (HP:0001408)2.17369534
112Retinal atrophy (HP:0001105)2.16408082
113Reduced antithrombin III activity (HP:0001976)2.16304638
114Abnormality of alanine metabolism (HP:0010916)2.14924280
115Hyperalaninemia (HP:0003348)2.14924280
116Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.14924280
117Nausea (HP:0002018)2.12619556
118Confusion (HP:0001289)2.12212002
119Recurrent gram-negative bacterial infections (HP:0005420)2.09402217
120Aplasia/hypoplasia of the uterus (HP:0008684)2.08936882
121Abnormality of the proximal phalanges of the hand (HP:0009834)2.07431278
122Hypoglycemic seizures (HP:0002173)2.06885182
123Absent phalangeal crease (HP:0006109)2.06854282
124Abnormality of the pulmonary veins (HP:0011718)2.05583394
125Pancreatitis (HP:0001733)2.05428426
126Myocardial infarction (HP:0001658)2.05411273
127Abnormality of renin-angiotensin system (HP:0000847)2.04074631
128Skin nodule (HP:0200036)2.03704668
129Abnormal urine phosphate concentration (HP:0012599)2.03190164
130Abnormality of the alveolar ridges (HP:0006477)2.03094336
131Partial agenesis of the corpus callosum (HP:0001338)2.02407368
132Hypokalemia (HP:0002900)2.01969252
133Hypophosphatemic rickets (HP:0004912)2.01571238
134Hyperaldosteronism (HP:0000859)2.00621376
135Abnormality of alkaline phosphatase activity (HP:0004379)1.99701848
136Hypophosphatemia (HP:0002148)1.99369671
137Renal salt wasting (HP:0000127)1.99043285
138Short femoral neck (HP:0100864)1.99031489
139Ureteral duplication (HP:0000073)1.97572595
140Systemic lupus erythematosus (HP:0002725)1.96689479
141Tetany (HP:0001281)1.94626104
142Mitral stenosis (HP:0001718)1.91953904
143Congenital sensorineural hearing impairment (HP:0008527)1.88209896
144Flared iliac wings (HP:0002869)1.86865042
145Type II lissencephaly (HP:0007260)1.85577290
146Abnormal ossification of hand bones (HP:0005921)1.85331365
147Abnormality of the renal cortex (HP:0011035)1.82194709
148Renal cortical cysts (HP:0000803)1.82030435
149Pancreatic cysts (HP:0001737)1.81134649
150Hyperventilation (HP:0002883)1.80090570
151Abolished electroretinogram (ERG) (HP:0000550)1.74623754

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BCKDK6.50893027
2WNK45.44433912
3WNK34.89957352
4OXSR14.26724648
5FGFR43.23193315
6SIK12.82408820
7ADRBK22.79194133
8ERN12.62440507
9STK38L2.44257180
10INSRR2.38284323
11STK392.30524035
12BMPR1B2.23665810
13ACVR1B2.13955408
14MAP4K21.93095219
15PDK41.92979385
16PDK31.92979385
17MST1R1.92359824
18PRPF4B1.91461597
19TAOK21.89460970
20NEK11.77610564
21AKT31.75755646
22ERBB41.68745553
23PKN21.67867326
24GRK11.61245442
25PINK11.60234204
26ZAK1.52618934
27TRIB31.45044760
28MAP2K41.39796234
29MAPK111.35444023
30MAP3K71.35365877
31TAOK31.33017879
32TXK1.31078434
33SGK2231.29017827
34SGK4941.29017827
35PDK21.25876192
36TLK11.23558772
37PTK61.23041979
38LATS11.18679147
39DYRK21.15102412
40TIE11.14326283
41LIMK11.12157835
42MAPKAPK31.09439468
43PIK3CG1.06579438
44PRKAA21.04989939
45NLK1.04214068
46ABL21.03870417
47NTRK31.03622425
48RPS6KA51.03253341
49MAP3K31.03036752
50SGK31.02291720
51FLT31.02263670
52STK381.01525396
53EPHB10.94909626
54MAPK130.94869111
55CASK0.94013509
56SGK20.93530713
57FRK0.91845635
58ADRBK10.89989056
59TYK20.89901756
60GRK60.89298245
61NEK90.87841797
62PRKAA10.86204920
63MYLK0.86030746
64NUAK10.85703609
65GSK3A0.84139933
66MAP2K30.81564710
67DAPK20.79138920
68OBSCN0.78036615
69MELK0.77194753
70PRKCE0.77077916
71JAK20.77047058
72KDR0.76890940
73NME10.76569527
74WNK10.76005299
75BRSK20.75457187
76CAMKK20.72262145
77FGFR20.71869204
78MAPKAPK50.70664817
79DYRK1B0.69380480
80MAPK150.69287092
81NEK20.68725346
82MET0.68202789
83TGFBR20.65756115
84RIPK10.65673076
85PRKCZ0.65172968
86PTK20.64567220
87MAPK120.63658550
88FGFR30.62155223
89PRKACG0.59236217
90PAK30.58953644
91MAP3K140.58652476
92MUSK0.58007842
93CSNK1A10.57220971
94TTN0.57007483
95ERBB20.56147045
96PDPK10.55765236
97MAP3K110.53612198
98MAPK40.52368118
99MAP3K40.51047866
100PKN10.50992495
101CSNK1D0.50075870
102JAK10.49221101
103CAMK1D0.47936899
104DDR20.47161336
105CAMK2A0.46136380
106PNCK0.46008115
107CAMK2G0.42757947
108CAMK40.41201348
109LRRK20.41119936
110PRKG10.39876445
111TBK10.39767214
112MAPK30.39505555
113MAP3K100.38892519
114MAP2K60.37680023
115RPS6KA30.36110111
116MARK10.34958133
117PDK10.34882739
118TNIK0.34384293
119CSK0.33851788
120CDK60.32522450
121ICK0.31406247
122FER0.30939632
123MAP3K50.30632712
124EIF2AK30.30373385
125PIK3CA0.29973970
126SGK10.29410824
127MAPK10.29120846
128PRKCQ0.28558745
129PHKG20.28509481
130PHKG10.28509481
131IRAK30.27517600
132CAMK1G0.26795956
133MAPK70.25519044
134MTOR0.24800134
135MAP2K10.22619173
136IGF1R0.22502276
137AKT20.21865412
138PRKCA0.21804708
139PRKD10.21646574
140CSNK1G10.21372363
141PRKACA0.20804995
142LMTK20.20704582
143PRKACB0.17678337
144PRKCG0.15523838
145MAP3K20.15495360

Predicted pathways (KEGG)

RankGene SetZ-score
1Ascorbate and aldarate metabolism_Homo sapiens_hsa000533.58388584
2Primary bile acid biosynthesis_Homo sapiens_hsa001203.57579286
3Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004003.17448910
4Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006302.93181686
5Nitrogen metabolism_Homo sapiens_hsa009102.86442549
6Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.82459413
7Butanoate metabolism_Homo sapiens_hsa006502.79898247
8Fatty acid degradation_Homo sapiens_hsa000712.70734101
9Tryptophan metabolism_Homo sapiens_hsa003802.67648277
10Pentose and glucuronate interconversions_Homo sapiens_hsa000402.64108060
11Arginine biosynthesis_Homo sapiens_hsa002202.62416964
12Propanoate metabolism_Homo sapiens_hsa006402.54807530
13Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010402.50996977
14Glycine, serine and threonine metabolism_Homo sapiens_hsa002602.41748011
15Peroxisome_Homo sapiens_hsa041462.28931540
16Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.25315443
172-Oxocarboxylic acid metabolism_Homo sapiens_hsa012102.19278256
18Fatty acid metabolism_Homo sapiens_hsa012121.97915331
19Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.95343767
20beta-Alanine metabolism_Homo sapiens_hsa004101.89219063
21Complement and coagulation cascades_Homo sapiens_hsa046101.88535602
22Cyanoamino acid metabolism_Homo sapiens_hsa004601.83700440
23Pyruvate metabolism_Homo sapiens_hsa006201.80934019
24PPAR signaling pathway_Homo sapiens_hsa033201.79985879
25Histidine metabolism_Homo sapiens_hsa003401.69276526
26Chemical carcinogenesis_Homo sapiens_hsa052041.69022897
27Steroid hormone biosynthesis_Homo sapiens_hsa001401.67668724
28Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.67367159
29Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.60965374
30Bile secretion_Homo sapiens_hsa049761.59276487
31Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.56822941
32Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.55381747
33Drug metabolism - other enzymes_Homo sapiens_hsa009831.52563581
34Sulfur metabolism_Homo sapiens_hsa009201.49490416
35Carbon metabolism_Homo sapiens_hsa012001.46484515
36Selenocompound metabolism_Homo sapiens_hsa004501.45274551
37Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.44858811
38Phenylalanine metabolism_Homo sapiens_hsa003601.44121458
39Starch and sucrose metabolism_Homo sapiens_hsa005001.43875358
40Retinol metabolism_Homo sapiens_hsa008301.42790109
41Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.28762944
42Fatty acid elongation_Homo sapiens_hsa000621.24622878
43Vitamin digestion and absorption_Homo sapiens_hsa049771.24476074
44Biosynthesis of amino acids_Homo sapiens_hsa012301.23054214
45Caffeine metabolism_Homo sapiens_hsa002321.22407018
46Arginine and proline metabolism_Homo sapiens_hsa003301.17674433
47Cysteine and methionine metabolism_Homo sapiens_hsa002701.17639436
48Folate biosynthesis_Homo sapiens_hsa007901.13779678
49Tyrosine metabolism_Homo sapiens_hsa003501.13437034
50Staphylococcus aureus infection_Homo sapiens_hsa051501.07993303
51Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.07249707
52Lysine degradation_Homo sapiens_hsa003101.04544078
53ABC transporters_Homo sapiens_hsa020101.00513368
54Glutathione metabolism_Homo sapiens_hsa004800.99210284
55Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.94408306
56Steroid biosynthesis_Homo sapiens_hsa001000.89212123
57Maturity onset diabetes of the young_Homo sapiens_hsa049500.87060693
58Fat digestion and absorption_Homo sapiens_hsa049750.85490581
59Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.83471419
60Glycerolipid metabolism_Homo sapiens_hsa005610.76449075
61Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.75695194
62Sulfur relay system_Homo sapiens_hsa041220.72489963
63Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.59416681
64Pentose phosphate pathway_Homo sapiens_hsa000300.58062386
65Ether lipid metabolism_Homo sapiens_hsa005650.58037249
66Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.56065966
67Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.53044411
68Vitamin B6 metabolism_Homo sapiens_hsa007500.51749454
69Metabolic pathways_Homo sapiens_hsa011000.51582822
70One carbon pool by folate_Homo sapiens_hsa006700.51555240
71Aldosterone synthesis and secretion_Homo sapiens_hsa049250.51542899
72Fructose and mannose metabolism_Homo sapiens_hsa000510.46718591
73Phototransduction_Homo sapiens_hsa047440.42604135
74Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.38342532
75Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.37917998
76Circadian rhythm_Homo sapiens_hsa047100.36287180
77Galactose metabolism_Homo sapiens_hsa000520.30421765
78Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.29596440
79Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.29054118
80Insulin resistance_Homo sapiens_hsa049310.26556247
81Fatty acid biosynthesis_Homo sapiens_hsa000610.25827328
82Adipocytokine signaling pathway_Homo sapiens_hsa049200.23206970
83Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.20366797
84Serotonergic synapse_Homo sapiens_hsa047260.20176245
85alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.20148829
86Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.19548760
87Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.15889795
88Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.15273057
89Protein digestion and absorption_Homo sapiens_hsa049740.15129143
90Mineral absorption_Homo sapiens_hsa049780.14468990
91TGF-beta signaling pathway_Homo sapiens_hsa043500.12410716
92Glucagon signaling pathway_Homo sapiens_hsa049220.11512295
93Collecting duct acid secretion_Homo sapiens_hsa049660.08751593
94Sphingolipid metabolism_Homo sapiens_hsa006000.07677001
95Renin-angiotensin system_Homo sapiens_hsa046140.07253003
96Oxidative phosphorylation_Homo sapiens_hsa001900.07180355
97AMPK signaling pathway_Homo sapiens_hsa041520.05088687
98Other glycan degradation_Homo sapiens_hsa005110.03777522
99Vascular smooth muscle contraction_Homo sapiens_hsa042700.03317877
100Glycosaminoglycan degradation_Homo sapiens_hsa005310.03049643
101Carbohydrate digestion and absorption_Homo sapiens_hsa049730.02540632
102Linoleic acid metabolism_Homo sapiens_hsa005910.01971235
103Glycerophospholipid metabolism_Homo sapiens_hsa005640.01547587
104Prion diseases_Homo sapiens_hsa050200.01444894
105Cardiac muscle contraction_Homo sapiens_hsa04260-0.1681221
106Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa00520-0.1653708
107Regulation of autophagy_Homo sapiens_hsa04140-0.1637200
108Alzheimers disease_Homo sapiens_hsa05010-0.1390168
109Ovarian steroidogenesis_Homo sapiens_hsa04913-0.1303958
110Lysosome_Homo sapiens_hsa04142-0.1125169
111Insulin signaling pathway_Homo sapiens_hsa04910-0.1088238
112Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa04961-0.0695248
113Parkinsons disease_Homo sapiens_hsa05012-0.0367845
114Arachidonic acid metabolism_Homo sapiens_hsa00590-0.0304708
115Thyroid hormone synthesis_Homo sapiens_hsa04918-0.0276939
116Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa04960-0.0134101

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